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Shimizu, Akira

Specially Contracted Staff Member

Shimizu, Akira
list
    Last Updated :2022/08/06

    Basic Information

    Professional Memberships

    • The American Society for Biochemistry and Molecular Biology
    • 日本分子生物学会
    • 日本免疫学会
    • 日本生化学会
    • The American Society for Biochemistry and Molecular Biology
    • Japanese Society for Immunology
    • The Molecular Biology Society of Japan
    • The Japanese Biochmical Society

    Academic Degree

    • 医学博士(大阪大学)

    Academic Resume (Graduate Schools)

    • 大阪大学, 大学院医学研究科博士課程生理系専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 東京大学, 医学部医学科, 卒業

    High School

    • High School

      武蔵高等学校

    Research History

    • From 1992, To 2003
      京都大学遺伝子実験施設教授
    • From 1992, To 2003
      Professor,
    • From 2003
      -京都大学医学研究科附属ゲノム医学センター教授
    • From 2003
      - Professor, Center for Genomic Medicine,
    • From 2001
      -京都大学医学部附属病院教授
    • From 2001
      - Professor, Translational Reserach Center,
    • From 1987, To 1992
      京都大学遺伝子実験施設助教授
    • From 1987, To 1992
      Associate Professor,
    • From 1986, To 1987
      Harvard Medical School 研究員
    • From 1986, To 1987
      Research Fellow, Harvard Medical School
    • From 1984, To 1987
      Kyoto University, Faculty of Medicine
    • From 1984, To 1987
      Assistant Professor,
    • From 1987
      Kyoto University, Faculty of Medicine
    • From 1987
      Lecturer,
    • From 1983, To 1984
      Osaka University, Faculty of Medicine
    • From 1983, To 1984
      Assistant Professor,
    • Graduate School of Medicine, Kyoto University, 大学院医学研究科
    • Kyoto University Hospital
    • Kyoto University
    • Center for Molecular Biology and Genetics,
    • Kyoto University
    • Center for Molecular Biology and Genetics,
    • Faculty of Medicine, Kyoto University, 医学部
    • Faculty of Medicine, Kyoto University, 医学部
    • Osaka University Medical School

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2022/08/06

      Research

      Research Interests

      • 遺伝子発現
      • 遺伝子構造
      • chromatin structure
      • TCR
      • immunoglobulin
      • gene expression
      • gene organization

      Research Areas

      • Life sciences, Immunology
      • Life sciences, Medical biochemistry
      • Life sciences, Molecular biology
      • Life sciences, Immunology
      • Life sciences, Medical biochemistry
      • Life sciences, Molecular biology

      Papers

      • Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb -/- Runx2 +/- Murine Incisors
        Kazuyuki Saito; Katsu Takahashi; Boyen Huang; Masakazu Asahara; Honoka Kiso; Yumiko Togo; Hiroko Tsukamoto; Sayaka Mishima; Masaki Nagata; Machiko Iida; Yoshihito Tokita; Masato Asai; Akira Shimizu; Toshihisa Komori; Hidemitsu Harada; Mary MacDougall; Manabu Sugai; Kazuhisa Bessho
        Scientific Reports, 01 Dec. 2018, Peer-reviewed
      • Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia
        Yu Isobe; Katsu Takahashi; Honoka Kiso; Kazumasa Nakao; Masayuki Ikeno; Noriaki Koyama; Manabu Sugai; Akira Shimizu; Hironori Haga; Kazuhisa Bessho
        Archives of Oral Biology, 01 Sep. 2018, Peer-reviewed
      • A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction mode
        Kumagai, M; Minakata, K; Masumoto, H; Yamamoto, M; Yonezawa, A; Ikeda, T; Uehara, K; Yamazaki, K; Ikeda, T; Matsubara, K; Yokode, M; Shimizu, A; Tabata, Y; Sakata, R; Minatoya, K
        Heart and Vessels, May 2018, Peer-reviewed
      • Patterns of clinical practice for sentinel lymph node biopsy in women with node-negative breast cancer: the results of a national survey in Japan
        Takafumi Ikeda; Tomoharu Sugie; Akira Shimizu; Masakazu Toi
        BREAST CANCER, Mar. 2017, Peer-reviewed
      • Sentinel lymph node biopsy using indocyanine green fluorescence in early-stage breast cancer: a meta-analysis
        Tomoharu Sugie; Takafumi Ikeda; Atsushi Kawaguchi; Akira Shimizu; Masakazu Toi
        INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Feb. 2017, Peer-reviewed
      • Transcutaneous oxygen pressure as a surrogate Index of lower limb amputation
        Hiroomi Nishio; Kenji Minakata; Atsushi Kawaguchi; Motoyuki Kumagai; Takafumi Ikeda; Akira Shimizu; Masayuki Yokode; Satoshi Morita; Ryuzo Sakata
        INTERNATIONAL ANGIOLOGY, Dec. 2016, Peer-reviewed
      • Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study
        Takayuki Nakagawa; Michio Yamamoto; Kozo Kumakawa; Shin-ichi Usami; Naohito Hato; Keiji Tabuchi; Mariko Takahashi; Keizo Fujiwara; Akira Sasaki; Shizuo Komune; Norio Yamamoto; Harukazu Hiraumi; Tatsunori Sakamoto; Akira Shimizu; Juichi Ito
        AURIS NASUS LARYNX, Oct. 2016, Peer-reviewed
      • A pilot study of regenerative therapy using controlled release of recombinant human fibroblast growth factor for patients with pre-collapse osteonecrosis of the femoral head
        Yutaka Kuroda; Ryuta Asada; Kazutaka So; Atsushi Yonezawa; Manabu Nankaku; Kumi Mukai; Toshiko Ito-Ihara; Harue Tada; Michio Yamamoto; Toshinori Murayama; Satoshi Morita; Yasuhiko Tabata; Masayuki Yokode; Akira Shimizu; Shuichi Matsuda; Haruhiko Akiyama
        INTERNATIONAL ORTHOPAEDICS, Aug. 2016, Peer-reviewed
      • Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.
        Yuki Sato; Akiko Mii; Yoko Hamazaki; Harumi Fujita; Hirosuke Nakata; Kyoko Masuda; Shingo Nishiyama; Shinsuke Shibuya; Hironori Haga; Osamu Ogawa; Akira Shimizu; Shuh Narumiya; Tsuneyasu Kaisho; Makoto Arita; Masashi Yanagisawa; Masayuki Miyasaka; Kumar Sharma; Nagahiro Minato; Hiroshi Kawamoto; Motoko Yanagita
        JCI insight, 21 Jul. 2016, Peer-reviewed
      • Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis
        Kazuyuki Saito; Katsu Takahashi; Masakazu Asahara; Honoka Kiso; Yumiko Togo; Hiroko Tsukamoto; Boyen Huang; Manabu Sugai; Akira Shimizu; Masaharu Motokawa; Harold C. Slavkin; Kazuhisa Bessho
        BMC DEVELOPMENTAL BIOLOGY, May 2016, Peer-reviewed
      • Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia.
        Motoyuki Kumagai; Akira Marui; Yasuhiko Tabata; Takahide Takeda; Masaya Yamamoto; Atsushi Yonezawa; Shiro Tanaka; Shigeki Yanagi; Toshiko Ito-Ihara; Takafumi Ikeda; Toshinori Murayama; Satoshi Teramukai; Toshiya Katsura; Kazuo Matsubara; Koji Kawakami; Masayuki Yokode; Akira Shimizu; Ryuzo Sakata
        Heart and vessels, May 2016, Peer-reviewed
      • Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer
        Junzo Hamanishi; Masaki Mandai; Takafumi Ikeda; Manabu Minami; Atsushi Kawaguchi; Toshinori Murayama; Masashi Kanai; Yukiko Mori; Shigemi Matsumoto; Shunsuke Chikuma; Noriomi Matsumura; Kaoru Abiko; Tsukasa Baba; Ken Yamaguchi; Akihiko Ueda; Yuko Hosoe; Satoshi Morita; Masayuki Yokode; Akira Shimizu; Tasuku Honjo; Ikuo Konishi
        JOURNAL OF CLINICAL ONCOLOGY, Dec. 2015, Peer-reviewed
      • ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents.
        Boyen Huang; Katsu Takahashi; Tomoko Goto; Honoka Kiso; Manabu Sugai; Akira Shimizu; Shinji Kosugi; Kazuhisa Bessho
        Journal of maxillofacial and oral surgery, Jun. 2015, Peer-reviewed
      • Activation of B1a Cells in Peritoneal Cavity by T Cell-Independent Antigen Expressed on Polymeric Micelle
        Cheol Joo Kim; Eri Hara; Akira Shimizu; Manabu Sugai; Shunsaku Kimura
        JOURNAL OF PHARMACEUTICAL SCIENCES, May 2015, Peer-reviewed
      • Mitochondrial function provides instructive signals for activation-induced B-cell fates
        Kyoung-Jin Jang; Hiroto Mano; Koji Aoki; Tatsunari Hayashi; Akihiko Muto; Yukiko Nambu; Katsu Takahashi; Katsuhiko Itoh; Shigeru Taketani; Stephen L. Nutt; Kazuhiko Igarashi; Akira Shimizu; Manabu Sugai
        NATURE COMMUNICATIONS, Apr. 2015, Peer-reviewed
      • Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol.
        Eriko Sumi; Tomoharu Sugie; Kenichi Yoshimura; Harue Tada; Takafumi Ikeda; Eiji Suzuki; Yoshimasa Tanaka; Satoshi Teramukai; Akira Shimizu; Masakazu Toi; Nagahiro Minato
        Journal of translational medicine, 25 Nov. 2014, Peer-reviewed
      • A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment
        Takayuki Nakagawa; Kozo Kumakawa; Shin-ichi Usami; Naohito Hato; Keiji Tabuchi; Mariko Takahashi; Keizo Fujiwara; Akira Sasaki; Shizuo Komune; Tatsunori Sakamoto; Harukazu Hiraumi; Norio Yamamoto; Shiro Tanaka; Harue Tada; Michio Yamamoto; Atsushi Yonezawa; Toshiko Ito-Ihara; Takafumi Ikeda; Akira Shimizu; Yasuhiko Tabata; Juichi Ito
        BMC MEDICINE, Nov. 2014, Peer-reviewed
      • Preclinical Validation of Talaporfin Sodium-Mediated Photodynamic Therapy for Esophageal Squamous Cell Carcinoma
        Shinya Ohashi; Osamu Kikuchi; Mihoko Tsurumaki; Yukie Nakai; Hiroi Kasai; Takahiro Horimatsu; Shin'ichi Miyamoto; Akira Shimizu; Tsutomu Chiba; Manabu Muto
        PLOS ONE, Aug. 2014, Peer-reviewed
      • Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis
        Hiroyuki Ariyasu; Hiroshi Iwakura; Naoichiro Yukawa; Toshinori Murayama; Masayuki Yokode; Harue Tada; Kenichi Yoshimura; Satoshi Teramukai; Tatsuya Ito; Akira Shimizu; Atsushi Yonezawa; Kenji Kangawa; Tsuneyo Mimori; Takashi Akamizu
        ENDOCRINE JOURNAL, Jul. 2014, Peer-reviewed
      • Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations
        Honoka Kiso; Katsu Takahashi; Kazuyuki Saito; Yumiko Togo; Hiroko Tsukamoto; Boyen Huang; Manabu Sugai; Akira Shimizu; Yasuhiko Tabata; Aris N. Economides; Harold C. Slavkin; Kazuhisa Bessho
        PLOS ONE, May 2014, Peer-reviewed
      • Prospective signs of cleidocranial dysplasia in Cebpb deficiency
        Boyen Huang; Katsu Takahashi; Ernest A. Jennings; Pongthorn Pumtang-on; Honoka Kiso; Yumiko Togo; Kazuyuki Saito; Manabu Sugai; Shizuo Akira; Akira Shimizu; Kazuhisa Bessho
        JOURNAL OF BIOMEDICAL SCIENCE, May 2014, Peer-reviewed
      • Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells
        Yuko Naito-Matsui; Shuhei Takada; Yoshinobu Kano; Tomonori Iyoda; Manabu Sugai; Akira Shimizu; Kayo Inaba; Lars Nitschke; Takeshi Tsubata; Shogo Oka; Yasunori Kozutsumi; Hiromu Takematsu
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2014, Peer-reviewed
      • Novel Collagen/Gelatin Scaffold with Sustained Release of Basic Fibroblast Growth Factor: Clinical Trial for Chronic Skin Ulcers
        Naoki Morimoto; Kenichi Yoshimura; Miyuki Niimi; Tatsuya Ito; Rino Aya; Junpei Fujitaka; Harue Tada; Satoshi Teramukai; Toshinori Murayama; Chikako Toyooka; Kazumi Miura; Satoru Takemoto; Norikazu Kanda; Katsuya Kawai; Masayuki Yokode; Akira Shimizu; Shigehiko Suzuki
        TISSUE ENGINEERING PART A, Sep. 2013, Peer-reviewed
      • Evasion from accelerated blood clearance of nanocarrier named as "lactosome" induced by excessive administration of Lactosome
        E. Hara; A. Makino; K. Kurihara; M. Sugai; A. Shimizu; I. Hara; E. Ozeki; S. Kimura
        Biochimica et Biophysica Acta - General Subjects, Aug. 2013, Peer-reviewed
      • Comparison of the Indocyanine Green Fluorescence and Blue Dye Methods in Detection of Sentinel Lymph Nodes in Early-stage Breast Cancer
        Tomoharu Sugie; Terumasa Sawada; Nobumi Tagaya; Takayuki Kinoshita; Kazuhiko Yamagami; Hirofumi Suwa; Takafumi Ikeda; Kenichi Yoshimura; Miyuki Niimi; Akira Shimizu; Masakazu Toi
        ANNALS OF SURGICAL ONCOLOGY, Jul. 2013, Peer-reviewed
      • Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process
        B. Huang; K. Takahashi; T. Sakata-Goto; H. Kiso; Y. Togo; K. Saito; H. Tsukamoto; M. Sugai; S. Akira; A. Shimizu; K. Bessho
        Oral Diseases, Mar. 2013, Peer-reviewed
      • In situ differentiation of CD8 alpha alpha T cells from CD4 T cells in peripheral lymphoid tissues
        Yukiko Nambu; Tatsunari Hayashi; Kyoung-Jin Jang; Koji Aoki; Hiroto Mano; Keiko Nakano; Motomi Osato; Katsu Takahashi; Katsuhiko Itoh; Satoshi Teramukai; Toshihisa Komori; Jun Fujita; Yoshiaki Ito; Akira Shimizu; Manabu Sugai
        SCIENTIFIC REPORTS, Sep. 2012, Peer-reviewed
      • Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis
        Tomoko Sakata-Goto; Katsu Takahashi; Honoka Kiso; Boyen Huang; Hiroko Tsukamoto; Mitsuru Takemoto; Tatsunari Hayashi; Manabu Sugai; Takashi Nakamura; Yoshifumi Yokota; Akira Shimizu; Harold Slavkin; Kazuhisa Bessho
        BONE, Jan. 2012, Peer-reviewed
      • An exploratory clinical trial for combination wound therapy with a novel medical matrix and fibroblast growth factor in patients with chronic skin ulcers: a study protocol
        Naoki Morimoto; Kenichi Yoshimura; Miyuki Niimi; Tatsuya Ito; Harue Tada; Satoshi Teramukai; Toshinori Murayama; Chikako Toyooka; Satoru Takemoto; Katsuya Kawai; Masayuki Yokode; Akira Shimizu; Shigehiko Suzuki
        AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2012, Peer-reviewed
      • Increased Risk of Temporomandibular Joint Closed Lock: A Case-Control Study of ANKH Polymorphisms
        Boyen Huang; Katsu Takahashi; Tomoko Sakata; Honoka Kiso; Manabu Sugai; Kazuma Fujimura; Akira Shimizu; Shinji Kosugi; Tosiya Sato; Kazuhisa Bessho
        PLOS ONE, Oct. 2011, Peer-reviewed
      • A novel synthetic material for spinal fusion: a prospective clinical trial of porous bioactive titanium metal for lumbar interbody fusion
        Shunsuke Fujibayashi; Mitsuru Takemoto; Masashi Neo; Tomiharu Matsushita; Tadashi Kokubo; Kenji Doi; Tatsuya Ito; Akira Shimizu; Takashi Nakamura
        EUROPEAN SPINE JOURNAL, Sep. 2011, Peer-reviewed
      • Runx3 Is Required for Full Activation of Regulatory T Cells To Prevent Colitis-Associated Tumor Formation
        Manabu Sugai; Koji Aoki; Motomi Osato; Yukiko Nambu; Kosei Ito; Makoto M. Taketo; Akira Shimizu
        JOURNAL OF IMMUNOLOGY, Jun. 2011, Peer-reviewed
      • Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety
        Akio Ido; Akihiro Moriuchi; Masatsugu Numata; Toshinori Murayama; Satoshi Teramukai; Hiroyuki Marusawa; Naohisa Yamaji; Hitoshi Setoyama; Il-Deok Kim; Tsutomu Chiba; Shuji Higuchi; Masayuki Yokode; Masanori Fukushima; Akira Shimizu; Hirohito Tsubouchi
        JOURNAL OF TRANSLATIONAL MEDICINE, May 2011, Peer-reviewed
      • Cross-priming of CD8(+) T cells in vivo by dendritic cells pulsed with autologous apoptotic leukemic cells in immunotherapy for elderly patients with acute myeloid leukemia
        Toshio Kitawaki; Norimitsu Kadowaki; Keiko Fukunaga; Yasunari Kasai; Taira Maekawa; Katsuyuki Ohmori; Tatsuya Itoh; Akira Shimizu; Kiyotaka Kuzushima; Tadakazu Kondo; Takayuki Ishikawa; Takashi Uchiyama
        EXPERIMENTAL HEMATOLOGY, Apr. 2011, Peer-reviewed
      • Functions of Runx in IgA Class Switch Recombination
        Manabu Sugai; Kakeru Watanabe; Yukiko Nambu; Tatsunari Hayashi; Akira Shimizu
        JOURNAL OF CELLULAR BIOCHEMISTRY, Feb. 2011, Peer-reviewed
      • Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
        Satoshi Tanaka; Shinji Maeda; Motomu Hashimoto; Chihiro Fujimori; Yoshinaga Ito; Shin Teradaira; Keiji Hirota; Hiroyuki Yoshitomi; Tomoya Katakai; Akira Shimizu; Takashi Nomura; Noriko Sakaguchi; Shimon Sakaguchi
        JOURNAL OF IMMUNOLOGY, Aug. 2010, Peer-reviewed
      • Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF-beta 1 and Retinoic Acid Signaling
        Kakeru Watanabe; Manabu Sugai; Yukiko Nambu; Motomi Osato; Tatsunari Hayashi; Miho Kawaguchi; Toshihisa Komori; Yoshiaki Ito; Akira Shimizu
        JOURNAL OF IMMUNOLOGY, Mar. 2010, Peer-reviewed
      • UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients
        Masahide Onoue; Tomohiro Terada; Masahiko Kobayashi; Toshiya Katsura; Shigemi Matsumoto; Kazuhiro Yanagihara; Takafumi Nishimura; Masashi Kanai; Satoshi Teramukai; Akira Shimizu; Masanori Fukushima; Ken-ichi Inui
        INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Apr. 2009, Peer-reviewed
      • CXCL13 production by an established lymph node stromal cell line via lymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways
        Hidenori Suto; Tomoya Katakai; Manabu Sugai; Tatsuo Kinashi; Akira Shimizu
        INTERNATIONAL IMMUNOLOGY, Apr. 2009, Peer-reviewed
      • Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs
        Tomoya Katakai; Hidenori Suto; Manabu Sugai; Hiroyuki Gonda; Atsushi Togawa; Sachiko Suematsu; Yukihiko Ebisuno; Koko Katagiri; Tatsuo Kinashi; Akira Shinlfizu
        JOURNAL OF IMMUNOLOGY, Nov. 2008, Peer-reviewed
      • Undesired meeting of lymphocytes: Organ-specific infiltration and the organization of ectopic lymphoid tissue in a murine experimental autoimmune gastritis
        Tomoya Katakai; Akira Shimizu
        IMMUNOLOGY LETTERS, Jun. 2008, Peer-reviewed
      • Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse
        Akiko Murashima-Suginami; Katsu Takahashi; Tomoko Sakata; Hiroko Tsukamoto; Manabu Sugai; Motoko Yanagita; Akira Shimizu; Takeshi Sakurai; Harold C. Slavkin; Kazuhisa Bessho
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2008, Peer-reviewed
      • Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
        Takashi Akamizu; Hiroshi Iwakura; Hiroyuki Ariyasu; Hiroshi Hosoda; Toshinori Murayama; Masayuki Yokode; Satoshi Teramukai; Hiroshi Seno; Tsutomu Chiba; Shunichi Noma; Yoshikatsu Nakai; Mikhiko Fukunaga; Yoshihide Nakai; Kenji Kangawa
        EUROPEAN JOURNAL OF ENDOCRINOLOGY, Apr. 2008, Peer-reviewed
      • IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice
        Tsunao Kishida; Yayoi Hiromura; Masaharu Shin-Ya; Hidetsugu Asada; Hiroko Kuriyama; Manabu Sugai; Akira Shimizu; Yoshifumi Yokota; Takemitsu Hama; Jiro Imanishi; Yasuo Hisa; Osam Mazda
        JOURNAL OF IMMUNOLOGY, Dec. 2007, Peer-reviewed
      • The network of fibroblastic reticular cells in the lymph node: Functional framework for immune surveillance
        Tomoya Katakai; Akira Shimizu
        Current Immunology Reviews, Nov. 2007, Peer-reviewed
      • Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation
        Akiko Murashima-Suginami; Katsu Takahashi; Tomohiro Kawabata; Tomoko Sakata; Hiroko Tsukamoto; Manabu Sugai; Motoko Yanagita; Akira Shimizu; Takeshi Sakurai; Harold C. Slavkin; Kazuhisa Bessho
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2007, Peer-reviewed
      • Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-Reactive TCR transgenic mouse
        Tomoya Katakai; Takashi Nomura; Hiroyuki Gonda; Manabu Sugai; Yasutoshi Agata; Akiyoshi Nishio; Tohru Masuda; Shimon Sakaguchi; Akira Shimizu
        JOURNAL OF IMMUNOLOGY, Dec. 2006, Peer-reviewed
      • Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3 '-UTRs
        Tomohiro Kubo; Tadashi Wada; Yuki Yamaguchi; Akira Shimizu; Hiroshi Handa
        NUCLEIC ACIDS RESEARCH, Dec. 2006, Peer-reviewed
      • Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-1 levels and bowel movement frequency and negatively with systolic blood pressure
        T Akamizu; T Murayama; S Teramukai; K Miura; Bando, I; T Irako; H Iwakura; H Ariyasu; H Hosoda; H Tada; A Matsuyama; S Kojima; T Wada; Y Wakatsuki; K Matsubayashi; T Kawakita; A Shimizu; M Fukushima; M Yokode; K Kangawa'
        JOURNAL OF ENDOCRINOLOGY, Feb. 2006, Peer-reviewed
      • A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion
        T Hara; T Katakai; JH Lee; Y Nambu; N Nakajima-Nagata; H Gonda; M Sugai; A Shimizu
        INTERNATIONAL IMMUNOLOGY, Feb. 2006, Peer-reviewed
      • Enhanced anti-fibrotic activity of plasmid DNA expressing small interference RNA for TGF-beta type II receptor for a mouse model of obstructive nephropathy by cationized gelatin prepared from different amine compounds
        T Kushibiki; N Nagata-Nakajima; M Sugai; A Shimizu; Y Tabata
        JOURNAL OF CONTROLLED RELEASE, Feb. 2006, Peer-reviewed
      • Choroid plexus ependymal cells host neural progenitor cells in the rat
        Y Itokazu; M Kitada; M Dezawa; A Mizoguchi; N Matsumoto; A Shimizu; C Ide
        GLIA, Jan. 2006, Peer-reviewed
      • Targeting of plasmid DNA to renal interstitial fibroblasts by cationized gelatin
        T Kushibiki; N Nagata-Nakajima; M Sugai; A Shimizu; Y Tabata
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2005, Peer-reviewed
      • Polymorphisms in PTCH1 affect the risk of ameloblastoma
        T Kawabata; K Takahashi; M Sugai; A Murashima-Suginami; S Ando; A Shimizu; S Kosugi; T Sato; M Nishida; K Murakami; T Iizuka
        JOURNAL OF DENTAL RESEARCH, Sep. 2005, Peer-reviewed
      • Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis
        T Kushibiki; N Nagata-Nakajima; M Sugai; A Shimizu; Y Tabata
        JOURNAL OF CONTROLLED RELEASE, Jul. 2005, Peer-reviewed
      • Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease
        H Hiratani; DW Bowden; S Ikegami; S Shirasawa; A Shimizu; Y Iwatani; T Akamizu
        JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, May 2005, Peer-reviewed
      • CpG inhibits IgE class switch recombination through suppression of NF kappa B activity, but not through Id2 or Bcl6
        T Kusunoki; M Sugai; H Gonda; Y Nambu; N Nagata-Nakajima; T Katakai; M Kusunoki; A Sakamoto; TD Takeshisa; T Nakahata; Y Yokota; A Shimizu
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2005, Peer-reviewed
      • SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis
        T Kusunoki; Okafuji, I; T Yoshioka; M Saito; R Nishikomori; T Heike; M Sugai; A Shimizu; T Nakahata
        JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Mar. 2005, Peer-reviewed
      • Delivery of small interference RNA to renal interstitial fibroblasts by cationized gelatin
        T. Kushibiki; N. Nakajima-Nagata; M. Sugai; A. Shimizu; Y. Tabata
        Polymer Preprints, Japan, 2005, Peer-reviewed
      • Chemokines and autoimmune diseases
        Tomoya Katakai; Akira Shimizu
        Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, Dec. 2004, Peer-reviewed
      • Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation
        JH Lee; T Katakai; T Hara; H Gonda; M Sugai; A Shimizu
        JOURNAL OF CELL BIOLOGY, Oct. 2004, Peer-reviewed
      • Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes
        T Katakai; T Hara; M Sugai; H Gonda; A Shimuzu
        JOURNAL OF EXPERIMENTAL MEDICINE, Sep. 2004, Peer-reviewed
      • Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies
        M Sugai; H Gonda; Y Nambu; Y Yokota; A Shimizu
        JOURNAL OF MOLECULAR MEDICINE-JMM, Sep. 2004, Peer-reviewed
      • A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells
        T Katakai; T Hara; JH Lee; H Gonda; M Sugai; A Shimizu
        INTERNATIONAL IMMUNOLOGY, Aug. 2004, Peer-reviewed
      • Characterization of V-H epsilon gene expressed in PBL from children with atopic diseases: detection of homologous V(H)1-69 derived transcripts from three unrelated patients
        Y Bando; A Shimizu; C Ra
        IMMUNOLOGY LETTERS, Jun. 2004, Peer-reviewed
      • In vitro induction of adult hepatic progenitor cells into insulin-producing cells
        N Nakajima-Nagata; T Sakurai; T Mitaka; T Katakai; E Yamato; J Miyazaki; Y Tabata; M Sugai; A Shimizu
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2004, Peer-reviewed
      • Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression
        N Nakajima-Nagata; M Sugai; T Sakurai; J Miyazaki; YH Tabata; A Shimizu
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2004, Peer-reviewed
      • Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects
        T Akamizu; K Takaya; T Irako; H Hosoda; S Teramukai; A Matsuyama; H Tada; K Miura; A Shimizu; M Fukushima; M Yokode; K Tanaka; K Kangawa
        EUROPEAN JOURNAL OF ENDOCRINOLOGY, Apr. 2004, Peer-reviewed
      • Transcription-coupled events associating with immunoglobulin switch region chromatin
        Y Nambu; M Sugai; H Gonda; CG Lee; T Katakai; Y Agata; Y Yokota; A Shimizu
        SCIENCE, Dec. 2003, Peer-reviewed
      • The balance between Pax5 and Id2 activities is the key to AID gene expression
        H Gonda; M Sugai; Y Nambu; T Katakai; Y Agata; KJ Mori; Y Yokota; A Shimizu
        JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2003, Peer-reviewed
      • Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis
        T Katakai; T Hara; M Sugai; H Gonda; A Shimizu
        JOURNAL OF IMMUNOLOGY, Oct. 2003, Peer-reviewed
      • T(H)2 dominance and defective development of a CD8(+) dendritic cell subset in Id2-deficient mice
        T Kusunoki; M Sugai; T Katakai; Y Omatsu; T Iyoda; K Inaba; T Nakahata; A Shimizu; Y Yokota
        JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jan. 2003, Peer-reviewed
      • Essential role of Id2 in negative regulation of IgE class switching
        M Sugai; H Gonda; T Kusunoki; T Katakai; Y Yokota; A Shimizu
        NATURE IMMUNOLOGY, Jan. 2003, Peer-reviewed
      • Chemokine-independent preference for T-helper-1 cells in transendothelial migration
        T Katakai; T Hara; M Sugai; H Gonda; Y Nambu; E Matsuda; Y Agata; A Shimizu
        JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Peer-reviewed
      • Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa
        H Arakawa; K Kuma; M Yasuda; S Ekino; A Shimizu; H Yamagishi
        JOURNAL OF IMMUNOLOGY, Jul. 2002, Peer-reviewed
      • Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or alpha(4)beta(7)-integrin at the lesions of autoimmune gastritis
        T Katakai; KJ Mori; T Masuda; A Shimizu
        INTERNATIONAL IMMUNOLOGY, Feb. 2002, Peer-reviewed
      • The IL-7 receptor controls the accessibility of the TCR gamma locus by Stat5 and histone acetylation
        SK Ye; Y Agata; HC Lee; H Kurooka; T Kitamura; A Shimizu; T Honjo; K Ikuta
        IMMUNITY, Nov. 2001, Peer-reviewed
      • DNA polymerase beta is not essential for the formation of palindromic (P) region of T cell receptor gene
        H Gonda; M Sugai; T Katakai; N Sugo; Y Aratani; H Koyama; KJ Mori; A Shimizu
        IMMUNOLOGY LETTERS, Aug. 2001, Peer-reviewed
      • Targeting of Kruppel-associated box-containing zinc finger proteins to centromeric heterochromatin - Implication for the gene silencing mechanisms
        E Matsuda; Y Agata; M Sugai; T Katakai; H Gonda; A Shimizu
        JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2001, Peer-reviewed
      • Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination
        Y Agata; T Katakai; SK Ye; M Sugai; H Gonda; T Honjo; K Ikuta; A Shimizu
        JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2001, Peer-reviewed
      • Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats
        H Kitao; H Arakawa; K Kuma; H Yamagishi; N Nakamura; S Furusawa; H Matsuda; M Yasuda; S Ekino; A Shimizu
        INTERNATIONAL IMMUNOLOGY, Jul. 2000, Peer-reviewed
      • Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays
        H Akasaka; T Akasaka; M Kurata; C Ueda; A Shimizu; T Uchiyama; H Ohno
        CANCER RESEARCH, May 2000, Peer-reviewed
      • Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene
        T Akasaka; H Akasaka; C Ueda; N Yonetani; Y Maesako; A Shimizu; H Yamabe; S Fukuhara; T Uchiyama; H Ohno
        JOURNAL OF CLINICAL ONCOLOGY, Feb. 2000, Peer-reviewed
      • The helix-loop-helix inhibitor Id2 and cell differentiation control
        Y. Yokota; S. Mori; S.-I. Nishikawa; A. Mansouri; P. Gruss; T. Kusunoki; T. Katakai; A. Shimizu
        Current Topics in Microbiology and Immunology, 2000, Peer-reviewed
      • Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150
        M Shimada; M Saito; T Katakai; A Shimizu; T Ichimura; S Omata; T Horigome
        JOURNAL OF BIOCHEMISTRY, Dec. 1999, Peer-reviewed
      • Two novel Kruppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1 beta/KRIP-1)
        Y Agata; E Matsuda; A Shimizu
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1999, Peer-reviewed
      • Differential localization of T(h)1 and T(h)2 cells in autoimmune gastritis
        T Katakai; KJ Mori; T Masuda; A Shimizu
        INTERNATIONAL IMMUNOLOGY, Sep. 1998, Peer-reviewed
      • Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc finger proteins by degenerate PCR
        Y Agata; E Matsuda; A Shimizu
        GENE, Jun. 1998, Peer-reviewed
      • Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase
        M Sugai; S Kondo; A Shimizu; T Honjo
        NUCLEIC ACIDS RESEARCH, Feb. 1998, Peer-reviewed
      • Structure of the TCR expressed on a gastritogenic T cell clone, II-6, and frequent appearance of similar clonotypes in mice bearing autoimmune gastritis
        T Katakai; Y Agata; A Shimizu; C Ohshima; A Nishio; M Inaba; S Kasakura; KJ Mori; T Masuda
        INTERNATIONAL IMMUNOLOGY, Dec. 1997, Peer-reviewed
      • Chicken immunoglobulin mu-chain gene: Germline organization and tandem repeats characteristic of class switch recombination
        H Kitao; H Arakawa; H Yamagishi; A Shimizu
        IMMUNOLOGY LETTERS, Sep. 1996, Peer-reviewed
      • Analysis of regulatory mechanism for humoral immunity using transgenic mice of rearranged immunoglobulin genes
        A. Shimizu
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1995, Peer-reviewed
      • TRANSFORMING GROWTH-FACTOR-BETA INDUCED CLASS SWITCH RECOMBINATION MAY BE MODIFIED DURING THE CELL-PROLIFERATION RESTORED BY IL-2 STIMULATION
        T IWASATO; Y KANARI; A SHIMIZU; T HONJO; H YAMAGISHI
        IMMUNOLOGY LETTERS, Feb. 1994, Peer-reviewed
      • THE HUMAN S-MU-BP-2, A DNA-BINDING PROTEIN-SPECIFIC TO THE SINGLE-STRANDED GUANINE-RICH SEQUENCE RELATED TO THE IMMUNOGLOBULIN-MU CHAIN SWITCH REGION
        Y FUKITA; TR MIZUTA; M SHIROZU; K OZAWA; A SHIMIZU; T HONJO
        JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1993, Peer-reviewed
      • ISOLATION OF CDNA-ENCODING A BINDING-PROTEIN SPECIFIC TO 5'-PHOSPHORYLATED SINGLE-STRANDED-DNA WITH G-RICH SEQUENCES
        TR MIZUTA; Y FUKITA; T MIYOSHI; A SHIMIZU; T HONJO
        NUCLEIC ACIDS RESEARCH, Apr. 1993, Peer-reviewed
      • THE COMPLETE MURINE IMMUNOGLOBULIN CLASS SWITCH REGION OF THE ALPHA-HEAVY CHAIN GENE-HIERARCHICAL REPETITIVE STRUCTURE AND RECOMBINATION BREAKPOINTS
        H ARAKAWA; T IWASATO; H HAYASHIDA; A SHIMIZU; T HONJO; H YAMAGISHI
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1993, Peer-reviewed
      • SYNTHESIS AND REGULATION OF TRANS-MESSENGER RNA ENCODING THE IMMUNOGLOBULIN-EPSILON HEAVY-CHAIN
        A SHIMIZU; T HONJO
        FASEB JOURNAL, Jan. 1993, Peer-reviewed
      • Molecular mechanism for immunoglobulin class switching and multiple isotype expression
        A. Shimizu
        Seikagaku. The Journal of Japanese Biochemical Society, 1993, Peer-reviewed
      • BIASED DISTRIBUTION OF RECOMBINATION SITES WITHIN S-REGIONS UPON IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION INDUCED BY TRANSFORMING GROWTH-FACTOR-BETA AND LIPOPOLYSACCHARIDE
        T IWASATO; H ARAKAWA; A SHIMIZU; T HONJO; H YAMAGISHI
        JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 1992, Peer-reviewed
      • ANTIGEN-INDUCED APOPTOTIC DEATH OF LY-1 B-CELLS RESPONSIBLE FOR AUTOIMMUNE-DISEASE IN TRANSGENIC MICE
        M MURAKAMI; T TSUBATA; M OKAMOTO; A SHIMIZU; S KUMAGAI; H IMURA; T HONJO
        NATURE, May 1992, Peer-reviewed
      • MAPPING OF THE NU-GENE USING CONGENIC NUDE STRAINS AND INSITU HYBRIDIZATION
        Y TAKAHASHI; A SHIMIZU; T SAKAI; Y ENDO; N OSAWA; H SHISA; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 1992, Peer-reviewed
      • A TRANSGENIC MODEL OF AUTOIMMUNE HEMOLYTIC-ANEMIA
        M OKAMOTO; M MURAKAMI; A SHIMIZU; S OZAKI; T TSUBATA; S KUMAGAI; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, Jan. 1992, Peer-reviewed
      • REGULATED EXPRESSION OF IMMUNOGLOBULIN TRANS-MESSENGER RNA CONSISTING OF THE VARIABLE REGION OF A TRANSGENIC-MU CHAIN AND CONSTANT REGIONS OF ENDOGENOUS ISOTYPES
        H HAN; M OKAMOTO; T HONJO; A SHIMIZU
        INTERNATIONAL IMMUNOLOGY, Dec. 1991, Peer-reviewed
      • DUPLICATED VARIABLE REGION GENES ACCOUNT FOR DOUBLE ISOTYPE EXPRESSION IN A HUMAN LEUKEMIC B-CELL LINE THAT GIVES RISE TO SINGLE ISOTYPE-EXPRESSING CELLS
        TR MIZUTA; N SUZUKI; A SHIMIZU; T HONJO
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1991, Peer-reviewed
      • CHARACTERIZATION OF THE ENHANCER REGION FOR GERMLINE TRANSCRIPTION OF THE GAMMA-3 CONSTANT REGION GENE OF HUMAN-IMMUNOGLOBULIN
        K KUZE; A SHIMIZU; T HONJO
        INTERNATIONAL IMMUNOLOGY, Jul. 1991, Peer-reviewed
      • SV40 T-ANTIGEN TRANSFORMS CALCITONIN CELLS OF THE THYROID BUT NOT CGRP-CONTAINING NEURONS IN TRANSGENIC MICE
        M BAETSCHER; E SCHMIDT; A SHIMIZU; P LEDER; MC FISHMAN
        ONCOGENE, Jul. 1991
      • TRANSSPLICING AS A POSSIBLE MOLECULAR MECHANISM FOR THE MULTIPLE ISOTYPE EXPRESSION OF THE IMMUNOGLOBULIN GENE
        A SHIMIZU; MC NUSSENZWEIG; H HAN; M SANCHEZ; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 1991, Peer-reviewed
      • The membrane exons of the pseudo-γ-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the γ1 gene
        K. Kinoshita; A. Shimizu; T. Honjo
        Immunology Letters, 1991, Peer-reviewed
      • CIRCULAR DNA IS EXCISED BY IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION
        T IWASATO; A SHIMIZU; T HONJO; H YAMAGISHI
        CELL, Jul. 1990, Peer-reviewed
      • Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells
        Paschalis Sideras; Tatsunobu-ryushin Mizuta; Hiroshi Kanamorl; Noboru Suzuki; Masaya Okamoto; Kogo Kuze; Hitoshi Ohno; Shoichi Dol; Shirou Fukuhara; Mohammed Sawkat Hassan; Lennart Hammarstöm; Smith Edward; Akira Shimzu; Tasuku Honjo
        International Immunology, Nov. 1989, Peer-reviewed
      • THE GENE FOR THE HUMAN MAST-CELL HIGH-AFFINITY IGE RECEPTOR ALPHA-CHAIN - CHROMOSOMAL LOCALIZATION TO IQ21-Q23 AND RFLP ANALYSIS
        TEPLER, I; CC MORTON; A SHIMIZU; RF HOLCOMBE; R EDDY; TB SHOWS; P LEDER
        AMERICAN JOURNAL OF HUMAN GENETICS, Nov. 1989, Peer-reviewed
      • EXPRESSION OF DIFFERENT COMBINATIONS OF INTERLEUKINS BY HUMAN T-CELL LEUKEMIC-CELL LINES THAT ARE CLONALLY RELATED
        T NOMA; H NAKAKUBO; M SUGITA; S KUMAGAI; M MAEDA; A SHIMIZU; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, May 1989, Peer-reviewed
      • THE GENE FOR THE RAT MAST-CELL HIGH-AFFINITY IGE RECEPTOR ALPHA-CHAIN - STRUCTURE AND ALTERNATIVE MESSENGER-RNA SPLICING PATTERNS
        TEPLER, I; A SHIMIZU; P LEDER
        JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1989, Peer-reviewed
      • MOLECULAR MECHANISM FOR IMMUNOGLOBULIN DOUBLE-ISOTYPE EXPRESSION
        A SHIMIZU; T KINASHI; MC NUSSENZWEIG; TR MIZUTA; P LEDER; T HONJO
        COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989, Peer-reviewed
      • A new vector and RNase H method for the subtractive hybridization
        K. Kuze; A. Shimizu; T. Honjo
        Nucleic Acids Research, 1989, Peer-reviewed
      • Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse
        A. Shimizu; M. C. Nussenzweig; T. R. Mizuta; P. Leder; T. Honjo
        Proceedings of the National Academy of Sciences of the United States of America, 1989, Peer-reviewed
      • Effect of human recombinant interleukin 4 on in vitro granulopoiesis of human bone marrow cells
        Hiroshi Kajitani; Hideo Enokihara; Satoshi Tsunogake; Naoto Takano; Kenji Saito; Shimpei Furusawa; Hideo Shishido; Takafumi Noma; Akira Shimizu; Tasuku Honjo
        Growth Factors, 1989
      • Human and rat mast cell high-affinity immunoglobulin E receptors: Characterization of putative α-chain gene products
        A. Shimizu; I. Tepler; P. N. Benfey; E. H. Berenstein; R. P. Siraganian; P. Leder
        Proceedings of the National Academy of Sciences of the United States of America, Dec. 1988
      • A LARGER NUMBER OF L-CHAINS (TAC) ENHANCE THE ASSOCIATION RATE OF INTERLEUKIN-2 TO THE HIGH-AFFINITY SITE OF THE INTERLEUKIN-2 RECEPTOR
        Y SAITO; H SABE; N SUZUKI; S KONDO; T OGURA; A SHIMIZU; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 1988, Peer-reviewed
      • A soluble \\'anchorminus\\' interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses
        N. Kondo; S. Kondo; A. Shimizu; T. Honjo; J. Hamuro
        Immunology Letters, 1988, Peer-reviewed
      • EVIDENCE FOR THE INTERLEUKIN-2 DEPENDENT EXPANSION OF LEUKEMIC-CELLS IN ADULT T-CELL LEUKEMIA
        M MAEDA; N ARIMA; Y DAITOKU; M KASHIHARA; H OKAMOTO; T UCHIYAMA; K SHIRONO; M MATSUOKA; T HATTORI; K TAKATSUKI; K IKUTA; A SHIMIZU; T HONJO; J YODOI
        BLOOD, Nov. 1987, Peer-reviewed
      • T-CELL REPLACING FACTOR INTERLEUKIN-5 INDUCES NOT ONLY B-CELL GROWTH AND DIFFERENTIATION, BUT ALSO INCREASED EXPRESSION OF INTERLEUKIN-2 RECEPTOR ON ACTIVATED B-CELLS
        N HARADA; M MATSUMOTO; N KOYAMA; A SHIMIZU; T HONJO; A TOMINAGA; K TAKATSU
        IMMUNOLOGY LETTERS, Jul. 1987, Peer-reviewed
      • Expression and function characterization of artificial mutants of interleukin-2 receptor
        S. Kondo; M. Kinoshita; A. Shimizu
        Nature, 1987, Peer-reviewed
      • PRODUCTION AND CHARACTERIZATION OF THE EXTRACYTOPLASMIC PORTION OF THE HUMAN INTERLEUKIN-2 RECEPTOR
        A SHIMIZU; N KONDO; S KONDO; J HAMURO; T HONJO
        MOLECULAR BIOLOGY & MEDICINE, Dec. 1986, Peer-reviewed
      • A JOINING-DIVERSITY-JOINING COMPLEX GENERATED BY INVERSION MECHANISM AND A VARIABLE-DIVERSITY COMPLEX IN THE BETA-CHAIN GENE OF THE HUMAN T-CELL RECEPTOR
        K IKUTA; T OGURA; A SHIMIZU; T HONJO
        NUCLEIC ACIDS RESEARCH, Jun. 1986, Peer-reviewed
      • Expression of functional human interleukin-2 receptor in mice T cells by cDNA transfection
        S. Kondo; A. Shimizu; M. Maeda; Y. Tagaya; J. Yodoi; T. Honjo
        Nature, Mar. 1986, Peer-reviewed
      • STRUCTURE AND FUNCTION OF THE INTERLEUKIN-2 RECEPTOR - AFFINITY CONVERSION MODEL
        A SHIMIZU; S KONDO; H SABE; N ISHIDA; T HONJO
        IMMUNOLOGICAL REVIEWS, 1986, Peer-reviewed
      • Molecular basis for two different affinity states of the interleukin 2 receptor: Affinity conversion model
        S. Kondo; A. Shimizu; Y. Saito; M. Kinoshita; T. Honjo
        Proceedings of the National Academy of Sciences of the United States of America, 1986, Peer-reviewed
      • MOLECULAR-CLONING AND STRUCTURE OF THE HUMAN INTERLEUKIN-2 RECEPTOR GENE
        N ISHIDA; H KANAMORI; T NOMA; T NIKAIDO; H SABE; N SUZUKI; A SHIMIZU; T HONJO
        NUCLEIC ACIDS RESEARCH, 1985, Peer-reviewed
      • ORIGIN OF HUMAN T-LYMPHOTROPHIC VIRUS-I-POSITIVE T-CELL LINES IN ADULT T-CELL LEUKEMIA - ANALYSIS OF T-CELL RECEPTOR GENE REARRANGEMENT
        M MAEDA; A SHIMIZU; K IKUTA; H OKAMOTO; M KASHIHARA; T UCHIYAMA; T HONJO; J YODOI
        JOURNAL OF EXPERIMENTAL MEDICINE, 1985, Peer-reviewed
      • LOW-FREQUENCY OF SOMATIC MUTATION IN BETA-CHAIN VARIABLE REGION GENES OF HUMAN T-CELL RECEPTORS
        K IKUTA; T OGURA; A SHIMIZU; T HONJO
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, Peer-reviewed
      • Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection
        H. Sabe; S. Kondo; A. Shimizu; Y. Tagaya; J. Yodoi; N. Kobayashi; M. Hatanaka; N. Matsunami; M. Maeda; T. Noma
        Molecular Biology and Medicine, 1984, Peer-reviewed
      • MOLECULAR-CLONING OF CDNA-ENCODING HUMAN INTERLEUKIN-2 RECEPTOR
        T NIKAIDO; A SHIMIZU; N ISHIDA; H SABE; K TESHIGAWARA; M MAEDA; T UCHIYAMA; J YODOI; T HONJO
        NATURE, 1984, Peer-reviewed
      • IMMUNOGLOBULIN CLASS SWITCHING
        A SHIMIZU; T HONJO
        CELL, 1984
      • JAPANESE WILD MOUSE, MUS-MUSCULUS-MOLOSSINUS, HAS DUPLICATED IMMUNOGLOBULIN-GAMMA-2A GENES
        A SHIMIZU; Y HAMAGUCHI; Y YAOITA; K MORIWAKI; K KONDO; T HONJO
        NATURE, 1982, Peer-reviewed
      • ORGANIZATION OF THE CONSTANT-REGION GENE FAMILY OF THE MOUSE IMMUNOGLOBULIN HEAVY-CHAIN
        A SHIMIZU; N TAKAHASHI; Y YAOITA; T HONJO
        CELL, 1982, Peer-reviewed
      • ORDERING OF MOUSE IMMUNOGLOBULIN HEAVY-CHAIN GENES BY MOLECULAR-CLONING
        A SHIMIZU; N TAKAHASHI; Y YAMAWAKIKATAOKA; Y NISHIDA; T KATAOKA; T HONJO
        NATURE, 1981, Peer-reviewed
      • STRUCTURE OF A REARRANGED GAMMA-1 CHAIN GENE AND ITS IMPLICATION TO IMMUNOGLOBULIN CLASS-SWITCH MECHANISM
        M OBATA; T KATAOKA; S NAKAI; H YAMAGISHI; N TAKAHASHI; Y YAMAWAKIKATAOKA; T NIKAIDO; A SHIMIZU; T HONJO
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, Peer-reviewed

      Misc.

      • Spontaneous lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouse.
        Tomoya Katakai; Takashi Nomura; Hiroyuki Gonda; Manabu Sugai; Shimon Sakaguchi; Akira Shimizu
        第36 回日本免疫学会総会(2006.12.11-13. 大阪), 11 Dec. 2006, Peer-reviewed
      • 分化抑制因子Id2 によるB 細胞最終分化抑制機構の解析
        中島(長田; 奈津紀; 權田裕之; 田畑泰彦; 横田義史; 清水章; 菅井学
        第28 回日本分子生物学会年会(2005.12.7-10 福岡), 2005, Peer-reviewed
      • カチオン化ゼラチンを用いたsiRNA の腎間質へのデリバリー
        櫛引俊宏; 中島奈津紀; 菅井学; 清水章; 田畑泰彦
        第54 回高分子学会年次大会(2005.5.25-27 横浜), 2005, Peer-reviewed
      • Delivery of small interference RNA of transforming \ngrowth factor beta 1 receptor by cationized gelatin.
        Kushibiki, T; Nagata-Nakajima, N; Sugai, M; Shimizu, A; Tabata, Y
        4th Asian International Symposium on Biomaterials (AISB4)and 2nd International Symposium on Fusion of Nano and Bio Technologies(FNB)(2004.11.16-18. Tsukuba), 16 Nov. 2004, Peer-reviewed
      • カチオン化ゼラチンを利用したsiRNA 発現ベクターに よる腎線維化進展抑制
        櫛引俊宏; 中島奈津紀; 菅井学; 清水章; 田畑泰彦
        第20 回日本DDS 学会学術集会(2004.7.15-16. 京都), 2004, Peer-reviewed

      Awards

      • 1991
        The Japanese Biochemical Society, Young Investigator Award

      External funds: Kakenhi

      • Novel regulatory T cells induced and differentiated from CD4 T cells
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Akira Shimizu
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        CD8T;免疫寛容;慢性炎症;免疫反応;免疫抑制;自己免疫;T cell;制御性T細胞;T細胞
      • Development of an interface to refer OMICS information into clinic
        Grant-in-Aid for Challenging Exploratory Research
        Kinki University
        Masaki MANDAI
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        卵巣癌;マイクロアレイ;細胞内シグナル;バイオインフォマティクス;インターフェース;マイクロアレイ解析;バーチャルカルテ
      • Feasibility of Molecularly Targeted Therapy for Tooth Regeneration
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Katsu Takahashi
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        歯の再生;歯数制御;分子標的治療;USAG-1;Runx2;CEBP/β;過剰歯;先天性無歯症;BMP-7;C/EBPβ;BMP7;ゼラチンスポンジ
      • Molecular mechanism of the regulation of antigen-specific immune reaction
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Akira Shimizu
        From 01 Apr. 2013, To 31 Mar. 2017, Project Closed
        自己免疫疾患;免疫抑制;獲得免疫;免疫寛容;自己免疫;免疫制御;腫瘍免疫;腫瘍免疫疾患
      • Search for methods to control and treat allergy by regulating class switch recombination
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Akira SHIMIZU
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        免疫学;クラススイッチ;遺伝子組換え;アレルギー;免疫制御
      • Feasibility of gene therapy for tooth regeneration by stimulation of a third dentition
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Katsu TAKAHASHI
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        歯の再生;歯数制御;第3生歯;遺伝子治療;USAG-1;分子標的治療;BMP-7;歯牙再生;BMP7
      • Elucidation of molecular mechanisms for the regulation of immune response by reconstruction of microenvironment and analyses of transcription factors and their networks
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Akira SHIMIZU
        From 01 Apr. 2009, To 31 Mar. 2013, Project Closed
        分子免疫学;免疫制御;転写因子;遺伝子組換え;抗体遺伝子;発現制御;免疫学;遺伝子;腸管免疫;制御性T細胞;IgA;Runx;retinoic acid;TGF-β1;自己免疫炎症;クラススイッチ
      • 3次リンパ組織形成における制御性T細胞誘導による自己免疫制御の可能性探求
        Grant-in-Aid for Exploratory Research
        Kyoto University
        清水 章
        Project Closed
        TCR遺伝子;制御性T細胞;転写制御;NFκB;RelA;RelB;IκB;自己免疫性胃炎
      • The Consolidation of Ethical Infrastructures Supporting Clinical Trials for the Development of Advanced Medicine Technology
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Toshinori MURAYAMA
        Project Closed
        患者権利擁護;自主臨床試験;補償;医療倫理;自主臨床研究;臨床研究
      • 遺伝子組換えを標的としたアレルギー制御の可能性検索
        Grant-in-Aid for Exploratory Research
        Kyoto University
        清水 章
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;Id2;IRF4;ヒストンアセチル化;Pax5;Bcl6
      • Mechanism s regulating the gene rearrangements in immune system
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Akira SHIMIZU
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;Id2;SIP;ヒストンアセチル化;Pax5;Bcl6;Bc16, immunoglobulin gene;class switching;transcriptional regulation;Id2;SIP;histone acetylation;Pax5;Bcl6
      • Bリンパ球の分化・活性化におけるゲノム機能変換の遺伝情報DECODE回路解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        清水 章
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;Id2;NFκB;ヒストンアセチル化;Pax5;Bc16;Bcl6
      • 転写制御因子の多機能性-翻訳調節へのクロストーク
        Grant-in-Aid for Exploratory Research
        Kyoto University
        清水 章
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;Id2;NFκB;ヒストンアセチル化;Pax5;Bcl6
      • Molecular analysis of ANKH toward gene therapy for TMD
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Manabu SUGAI
        Project Closed
        顎関節;ANKH;遺伝子治療;組み換えウイルス, tooth regenaration;USAG-1;diphyodont;polymorphism
      • Molecular analysis of tooth regeneration
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Kastuji TAKAHASHI
        Project Closed
        歯牙再生;USAG-1;歯数制御;頭部神経堤細胞;器官培養;組み換えウイルス, tooth regeneration;USAG-1;diphyodont;polymorphism
      • Bリンパ球の分化・活性化におけるクロマチン修飾・遺伝情報発現制御のネットワーク
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        清水 章
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;Id2;NFκB;CpGオリゴヌクレオチド;Pax5;Bcl6
      • Molecular analysis of Wnt, Shh-Ptch signaling in Ameloblastoma
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Mitsuo NISHIDA
        Project Closed
        エナメル上皮腫;CTNNB1;PTCH1;ポリモルフィズム;PTCH;β-カテニン;体細胞突然変異, ameloblastoma;CTNNB1;PTCH1;polymorphism
      • Mechanisms regulating the target specificity of gene rearrangements in immune system
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Akira SHIMIZU
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;Id2;NFκB;ヒストンアセチル化;Pax5;Bcl6, immunoglobulin gene;class switching;transcriptional regulation;Id2;NFκB;histone acetylation;Pax5;Bcl6
      • クロマチン構造修飾などによる遺伝子状態・細胞機能のエピゲノム性調節とその維持
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        清水 章
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;アクセシビリティー;E2A;Id2;アレルギー;ChIP
      • SNPを用いた顎変形症における遺伝要因のゲノム解析
        Grant-in-Aid for Exploratory Research
        Kyoto University
        飯塚 忠彦
        Project Closed
        顎変形症;ゲノム;遺伝要因
      • Analyasis of Ig somatic hypermutaion by establishing assay system using in Vitro culture
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Akira SHIMIZU
        Project Closed
        抗体遺伝子;AID;Pax5;Id2;E2A;転写制御;クラススイッチ;体細胞突然変異, immuriogologulin gene;AID;Pax5;Id2;E2A;transcription;class sitching;somatic hypermutation
      • Molecular Analysis in Temporomandibular disorder
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Kenichiro MURAKAMI
        Project Closed
        顎関節;ゲノム;遺伝子診断;遺伝要因;遺伝診断, Temporomandibular joint;gene diagnosis;ANKH
      • クロマチン構造の変化などによる遺伝子状態・細胞機能のエピゲノム性調節とその維持
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        清水 章
        Project Closed
        抗体遺伝子;クラススイッチ;転写制御;アクセシビリティー;E2A;Id2;アレルギー;ChIP
      • ヒト顎関節円板・滑膜病変に対するANK遺伝子を用いた遺伝子診断法の開発
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Kenichiro MURAKAMI
        Project Closed
        顎関節;遺伝子診断;ANK遺伝子;滑膜培養細胞;関節円板;滑順培養細胞, temporomandibular joint;gene diagnosis;ANK gene;synovial cell;ortiomlar disk
      • HTLV-I感染T細胞株の増殖性進展と造腫瘍性関連遺伝子の検索と同定
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Kyoto University
        前田 道之
        Project Closed
        成人T細胞白血病;ATL;HTLV-1;造腫瘍性;増殖進展;cDNAマイクロアレイ
      • クロマチン構造の変化とその維持による遺伝子状態のエピゲノム性調節とその伝達
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Kyoto University
        清水 章
        Project Closed
        転写抑制;ヘテロクロマチン;KRAB;co-repressor;遺伝子組換え;T細胞受容体;ヒストンアセチル化;ヒストン脱アセチル化酵素
      • クロマチン構造の変化とその維持による遺伝子状態のエピゲノム性調節とその伝達
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Kyoto University
        清水 章
        Project Closed
        転写抑制;ヘテロクロマチン;KRAB;Znフィンガー因子;co-repressor;KAP-1;ヒストンアセチル化;ヒストン脱アセチル化酵素
      • 抗体のクラススイッチに先行して誘導されるGermline転写産物の機能解析
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Kyoto University
        菅井 学
        Project Closed
        クラススイッチ;B細胞;分化;RNA;免疫;くみかえ;抗体;修ふく
      • Differential localization of CD4ィイD1+ィエD1 T lymphocyte subsets.
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Akira SHIMIZU
        Project Closed
        新生児胸腺摘除;自己免疫性胃炎;Th1;Th2亜集団;IL-4;γ-インターフェロン;血管透過能;血管内皮細胞;CD4陽性キラー;Th2サブセット;ケモカイン;T細胞受容体遺伝子導入マウス, Neonatal Thymectomy;Autoimmune Gastritis;Th1;Th2 subsets;IL-4;γ-Interferon;Transendothelial Migration;Endothelial Cells;CD4ィイD1+ィエD1 Killer Cells
      • 自己免疫性胃炎惹起性および抑制性T細胞のレパートリー
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Kyoto University
        清水 章
        Project Closed
        新生児胸腺摘除;自己免疫性胃炎;Th1;Th2亜集団;IL-4;γ-インターフェロン;血管透過能;血管内皮細胞;CD4陽性キラー
      • Studies on chicken immunoglobulin gene moditication and attinity maturation
        Grant-in-Aid for Scientific Research (C)
        Health Research Foundation;Kyoto University
        Hideo YAMAGISHI
        Project Closed
        ブルサ;胚中心;免疫グロブリン;PCR法;抗原親和性成熟;遺伝子変換;点突然変異;クラススイッチ組換え;抗体遺伝子;NPハプテン;抗原親和性;クラススイツチ組換え;FITCハプテン;高親和性;体細胞突然変異;クラススイッチ領域, Bursa Fabricius;Germinal center;Immunoglobulin;PCR method;Affinity maturation;Gene conversion;Point mutation;Class switch recombination
      • 自己免疫性胃炎惹起性T細胞とこれを抑制するT細胞のレパートリー
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        清水 章
        Project Closed
        新生児胸腺摘除;自己免疫性胃炎;T細胞クローン;T細胞抗原受容体遺伝子;クロノタイプ;遺伝子組換え;CDR3;CD4陽性キラー
      • ニワトリ抗体H鎖定常部遺伝子の構造と全構成
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        清水 章
        Project Closed
        抗体クラス変換;抗体遺伝子;S領域;鳥類;イントロン;遺伝子組換え;繰り返し配列;分子進化
      • ニワトリ抗体H鎖定常部遺伝子群の構成
        Grant-in-Aid for General Scientific Research (C)
        Kyoto University
        清水 章
        Project Closed
        抗体クラス変換;抗体遺伝子;S領域;鳥類;イントロン;遺伝子組換え;繰り返し配列;分子進化
      • 抗体クラス変換の調節とアレルギー
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        清水 章
        Project Closed
        抗体クラス変換;抗体遺伝子;アレルギー;CD40リガンド;トランス・スプライシング;非組換え型転写;トランスmRNA;多重アイソタイプ同時発現
      • Regulation of RNA processing in B lymphocyte differentiation
        Grant-in-Aid for international Scientific Research
        KYOTO UNIVERSITY
        Akira SHIMIZU
        Project Closed
        抗体クラス変換;抗体遺伝子;S領域;遺伝子組換え;非組換え型転写;トランス・スプライシング;トランスmRNA;多重アイソタイプ同時発現;アレルギー;CD40リガンド, Ig class Switching;Ig gene;S region;Gene rearrangement;germ-line transcript;trans-splicing;trans-mRNA;Multiple isotype expression
      • Analysis on Fc Receptor-mediated Signal Transductions
        Grant-in-Aid for Scientific Research (A)
        KYOTO UNIVERSITY
        Junji YODOI
        Project Closed
        Fc受容体;シグナル伝達;IgE;IgC;リンパ球;イムノグロブリン;IgG;lgE;lgG, Fc receptor;signal transduction;IgE;IgG;lymphocyte;immunoblobulin
      • 抗体クラス変換の制御・調節とアレルギー
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        清水 章
        Project Closed
        抗体クラス変換;抗体遺伝子;アレルギー;高親和性Tcε受容体;トランス・スプライシング;非組換え型転写;トランスmRNA;多重アイソタイプ同時発現
      • 非組換え型定常部遺伝子の転写による抗体多重アイソタイプ同時発現とクラス変換の制御
        Grant-in-Aid for General Scientific Research (C)
        Kyoto University
        清水 章
        Project Closed
        トランス・スプライシング;抗体遺伝子;抗体クラス変換;非組換え型転写;DNAの複製;多重アイソタイプ同時発現;トランスmRNA;遺伝子導入マウス
      • 抗体クラス変換の制御とアレルギー
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        清水 章
        Project Closed
        抗体クラス変換;抗体遺伝子;遺伝子組換え;スイッチ(S)領域;DNA結合蛋白;非組換え型転写;トランスmRNA;多重アイソタイプ同時発現
      • Development of a method for regulation of auto-reactive B cells using transgenic mouse carrying genes encoding an anti-self-erythrocyte antibody.
        Grant-in-Aid for Developmental Scientific Research (B)
        KYOTO UNIVERSITY
        Akira SHIMIZU
        Project Closed
        遺伝子導入マウス;CD5陽性B(B-1)細胞;自己免疫病;溶血性貧血;腹腔B細胞;消化管免疫;LPS;プログラム細胞死;CD5陽性B細胞;B細胞トレランス;腸管内抗原, Transgenic mouse;CD5^+ B cells (B-1 cells);B cells in abdominal cavity;Auto-immune disease;Hemolytic anemia;Gastro-intestinal immunity;LPS;Programd cell death
      • Study on recombination signal binding protein ; RBP-Jkappa
        Grant-in-Aid for international Scientific Research
        Kyoto University, Faculty of Medicine
        Toru NAKANO
        Project Closed
        遺伝子破壊;相同遺伝子組替え;発生;胎生期致死;転写制御因子;胚性幹細胞;ショウジョウバエ;末梢神経;遺伝子組換え, Gene targeting;Homologous recombination;Embryonic lethal;Development;Transcriptional regulator
      • Immunoglobulin multiple isotype expression by trans-splicing
        Grant-in-Aid for General Scientific Research (C)
        KYOTO UNIVERSITY
        Akira SHIMIZU
        Project Closed
        トランス・スプライシング;抗体遺伝子;抗体クラススイッチ;多重アイソタイプ同時発現;PCR;トランスmRNA;トランスジェニックマウス, Trans-splicing;Immunoglobulin Gene;Antibody Class Switching;Multiple Isotype Expression;P. C. R;Trans-mRNA;Transgenic Mouse
      • 抗赤血球自己抗体遺伝子導入マウスを用いた自己免疫性貧血治療法の検索
        Grant-in-Aid for Developmental Scientific Research (B)
        Kyoto University
        清水 章
        Project Closed
        自己抗体;自己免疫;溶血性貧血;トランスジェニックマウス;免疫寛容
      • Studies on immunoglobulin class switch recombination
        Grant-in-Aid for General Scientific Research (B)
        KYOTO UNIVERSITY
        Hideo YAMAGISHI
        Project Closed
        抗体遺伝子;クラススイッチ;LPSとTGFβ;IgA誘導;環状DNA;Sα領域;逐次的組換え;染色体構造変化;TGF-βとIL-2;細胞増殖;IgAクラススイッチ;Sμ;Sγ_3組換え;組換え点の均一化;クラススイッチ組換え;完全塩基配列;スイッチ組換え点;階層的反復配列;80塩基反復単位;染色体対合;クラススイツチ;組換え部位の偏り;遂次的組換え, Immunoglobulin gene;Class switch;LPS and TGF-beta;IgA switch induction;Circular DNA;Salpha region;Successive recombination;IL-2 stimulated proliferation
      • 遺伝子導入動物による発癌の研究
        Grant-in-Aid for Cancer Research
        Kumamoto University
        山村 研一
        Project Closed
        トランスジェニックマウス;多段階発癌;癌遺伝子;ES細胞;相同遺伝子組換え;遺伝子トラップ
      • 遺伝子導入動物による発癌の研究
        Grant-in-Aid for Cancer Research
        Kumamoto University
        山村 研一
        Project Closed
        トランスジェニックマウス;ES細胞;癌遺伝子;相同遺伝子組換え
      • Molecular mechanisms for immunoglobulin class switching
        Grant-in-Aid for international Scientific Research
        Center for Molecular Biology and Genetics, Kyoto University
        Tasuku HONJO
        Project Closed
        抗体遺伝子;クラススイッチ;遺伝子組換え;germline転写物;インタ-ロイキン4;環状DNA, immunoglobulin gene;class switch;rearrangement;germline transcript;interleukin 4;circular DNA
      • 遺伝子導入動物による発癌の研究
        Grant-in-Aid for Cancer Research
        Kumamoto University
        山村 研一
        Project Closed
        トランスジェニックマウス;癌遺伝子;ウイルス発癌;遺伝的背景;相同遺伝子組み換え;胚幹細胞
      • 免疫系における多様性発現機構の分子遺伝学的研究
        Grant-in-Aid for Specially Promoted Research
        Kyoto University
        本庶 佑
        Project Closed
        Bリンパ球;VDJ組換;骨髄多分化能細胞;ストロ-マ細胞;リコンビナ-ゼ;ショウジョウバエ;SーS組換え;環状DNA;抗体遺伝子再構成;DNA結合タンパク質;cDNAクローニング;integrase family;transgenic mouse;double isotype expression;trans splicing;ヒト抗体V_H鎖遺伝子;骨髄細胞からのリンパ球への分化;クラススイッチ;IgM^+IgG^+B細胞;IL-2;IL-2R;トランスジュニックマウス;NK細胞;抗体遺伝子D断片;Bリンパ球の分化;IL-4;IL-2リセプター;トランスジェーニックマウス;染色体マップ;IL-4遺伝子;IL-5遺伝子;免疫グロブリン遺伝子;リンフォカイン遺伝子;人工突然変異;インターロイキン2の受容体;インターロイキン5;エンハンサー
      • ヒトIL-2レセプターとその誘導因子(IL-2-R誘導因子)の遺伝子解析
        Grant-in-Aid for Special Project Research
        Kyoto University
        淀井 淳司
        Project Closed
        IL-2R;成人T型白血病;ADF;IL-1;KOLT-2抗体;CD28抗原;ED細胞;YT細胞

      External funds: others

      • Reinforcement of academic base for development of innovative new drug and medical treatment
        文部科学省 橋渡し研究加速ネットワークプログラム
        From 2012, To 2016
        高橋良輔
      • Clinical development to make medical technology fit for practical use
        文部科学省 橋渡し研究加戦略的推進プログラム
        From 01 Apr. 2017, To 31 Mar. 2018
        松田秀一
      list
        Last Updated :2022/08/06

        Education

        Teaching subject(s)

        • From Apr. 2013, To Mar. 2014
          Advanced Course in Immunology and Human Disorders
          Spring, 生命科学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Course in Immunology and Human Disorders
          Spring, 生命科学研究科
        • From Apr. 2014, To Mar. 2015
          Experimental Course and Seminar l
          Year-long, 生命科学研究科
        • From Apr. 2014, To Mar. 2015
          Experimental Course and Seminar 2
          Year-long, 生命科学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Experiments in Systemic Life Sciences
          Year-long, 生命科学研究科
        • From Apr. 2015, To Mar. 2016
          Experimental Course and Seminar
          Spring, 生命科学研究科
        • From Apr. 2015, To Mar. 2016
          Experimental Course and Seminar
          Fall, 生命科学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Course in Immunology and Human Disorders
          Fall, 生命科学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Experiments in Systemic Life Sciences
          Spring, 生命科学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Experiments in Systemic Life Sciences
          Fall, 生命科学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course and Seminar
          Spring, 生命科学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course and Seminar
          Fall, 生命科学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Course in Immunology and Human Disorders
          Spring, 生命科学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Experiments in Systemic Life Sciences
          Spring, 生命科学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Experiments in Systemic Life Sciences
          Fall, 生命科学研究科
        • From Apr. 2017, To Mar. 2018
          Experimental Course and Seminar
          Spring, 生命科学研究科
        • From Apr. 2017, To Mar. 2018
          Experimental Course and Seminar
          Fall, 生命科学研究科
        • From Apr. 2017, To Mar. 2018
          Introduction to Biology and Life Science
          Spring, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Advanced Course in Immunology and Human Disorders
          Fall, 生命科学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Experiments in Systemic Life Sciences
          Spring, 生命科学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Experiments in Systemic Life Sciences
          Fall, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar A
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar A
          Fall, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar B
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar B
          Fall, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar C
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar C
          Fall, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar D
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar D
          Fall, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course and Seminar
          Fall, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Course in Immunology and Human Disorders
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Experiments in Systemic Life Sciences
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Experiments in Systemic Life Sciences
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar A
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar A
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar B
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar B
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar C
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar C
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar D
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar D
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course and Seminar
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Biology and Life Science
          Spring, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Advanced Course in Immunology and Human Disorders
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Experiments in Systemic Life Sciences
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Experiments in Systemic Life Sciences
          Fall, 生命科学研究科
        list
          Last Updated :2022/08/06

          Administration

          School management (title, position)

          • From 01 Apr. 2008, To 31 Mar. 2011
            産官学連携本部運営協議会 委員
          • From 01 Apr. 2008, To 31 Mar. 2011
            放射性同位元素等管理委員会 委員
          • From 01 Apr. 2008, To 31 Mar. 2011
            組換えDNA実験安全委員会 委員長
          • From 01 Oct. 2008, To 30 Sep. 2010
            総長室特命補佐
          • From 01 Apr. 2011, To 31 Mar. 2013
            産官学連携本部運営協議会
          • From 01 Apr. 2008, To 10 Sep. 2013
            京都大学ヒトゲノム・遺伝子解析研究管理委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2015
            産官学連携本部運営協議会
          • From 01 Oct. 2010, To 30 Sep. 2014
            京都大学組み換えDNA実験安全委員会 委員長
          • From 01 Apr. 2013, To 31 Mar. 2015
            産官学連携本部運営協議会協議員 委員
          • From 11 Sep. 2013, To 31 Dec. 2015
            ヒトゲノム・遺伝子解析研究管理委員会 委員
          • From 01 Oct. 2014, To 30 Sep. 2016
            組換えDNA実験安全委員会 1号委員
          • From 01 Apr. 2015, To 31 Mar. 2017
            産官学連携本部運営協議会 7号協議員
          • From 01 Apr. 2015, To 31 Mar. 2017
            産官学連携本部運営協議会 7号委員
          • From 01 Apr. 2016
            研究倫理・安全推進委員会 委員
          • From 01 Apr. 2015, To 31 Mar. 2017
            放射線同位元素等専門委員会
          • From 01 Apr. 2011, To 31 Mar. 2013
            情報ネットワーク倫理委員会
          • From 01 Oct. 2016, To 30 Sep. 2018
            組換えDNA実験安全委員会 1号委員
          • From 18 Jul. 2013, To 30 Apr. 2015
            国際高等教育院 企画評価専門委員会 初修外国語部会 委員
          • From 01 Oct. 2018, To 31 Mar. 2020
            組換えDNA実験安全委員会 委員長
          • From 01 Apr. 2016, To 30 Sep. 2019
            研究倫理・安全推進委員会 委員
          • From 01 Oct. 2018, To 31 Mar. 2020
            組換えDNA実験安全委員会 委員長(~2019/9/30)、委員(2019/10/1~)
          • From 01 Oct. 2020, To 30 Sep. 2022
            組換えDNA実験安全委員会 委員

          Faculty management (title, position)

          • To 31 Mar. 2017
            医学研究科・医学部放射性同位元素等管理委員会
          • From 01 Apr. 2013
            医学部附属病院 臨床研究総合センター 副センター長
          • From 01 Apr. 2013
            医学部附属病院 臨床研究総合センター 開発企画部長
          • From 01 Oct. 2008, To 30 Sep. 2013
            寄附講座運営委員会(探索臨床腫瘍学)
          • To 31 Mar. 2019
            施設管理運営委員会 委員
          • To 30 Sep. 2015
            「次世代免疫制御を目指す創薬医学融合拠点」知財委員会
          • To 30 Sep. 2015
            「次世代免疫制御を目指す創薬医学融合拠点」開発推進委員会
          • From 01 Nov. 2001, To 31 Mar. 2020
            病院協議会 委員
          • From 01 Oct. 2012, To 30 Sep. 2014
            管理体制委員会
          • From 01 Apr. 2010
            附属ゲノム医学センター運営委員会
          • To 31 Mar. 2020
            iPS細胞臨床開発部運営委員会
          • To 31 Mar. 2018
            iPS等臨床試験センター整備専門委員会
          • To 31 Mar. 2020
            特定臨床研究実施管理委員会
          • To 31 Mar. 2020
            臨床研究総合センター協議会
          • To 31 Mar. 2020
            臨床研究総合センター運営会議
          • To 31 Mar. 2020
            臨床研究総合センター推進委員会
          • To 31 Mar. 2017
            臨床研究総合センター医療開発委員会
          • To 31 Mar. 2017
            高齢者ユニット運営委員会
          • To 31 Mar. 2019
            予算委員会
          • From 01 Apr. 2018, To 31 Mar. 2020
            研究開発戦略推進委員会
          • From 01 Apr. 2018, To 31 Mar. 2020
            シーズ選定委員会
          • From 01 Apr. 2018, To 31 Mar. 2020
            研究開発連絡会(再生医療) 委員長
          • From 01 Apr. 2018, To 31 Mar. 2020
            研究開発連絡会(医療機器) 委員長
          • From 01 Apr. 2018, To 31 Mar. 2020
            研究開発連絡会(医薬品) 委員長
          • From 01 Apr. 2017, To 31 Mar. 2018
            放射線障害予防委員会
          • From 01 Apr. 2019, To 31 Mar. 2020
            臨床研究総合センター財務委員会 委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            臨床研究総合センター人事委員会 委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            臨床研究総合センター開発企画部連絡会 委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            シーズ発掘委員会 委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            シーズ評価委員会 委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            臨床試験データ等の移転規程化に向けたワーキンググループ 委員
          list
            Last Updated :2022/08/06

            Academic, Social Contribution

            Committee Memberships

            • 評議員, 日本免疫学会
            • 評議員, 日本生化学会

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