Basic Information

Faculty

• Faculty of Engineering

Professional Memberships

• THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
• THE JAPAN NEUROSCIENCE SOCIETY
• Physiological Society of Japan
• THE JAPANESE BIOCHEMICAL SOCIETY
• Society for Neuroscience
• THE JAPANESE PHARMACOLOGICAL SOCIETY

Academic Degree

• 修士（工学）(京都大学)
• 博士（工学）(京都大学)

Research History

• From Oct. 2022, To Present

  京都大学エネルギー理工学研究所, 附属カーボンネガティブ・エネルギー研究センター, 助教 (兼任)
• From Sep. 2018, To Present

  Kyoto University, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Assistant Professor
• From Apr. 2015, To Aug. 2018

  藤田保健衛生大学, 総合医科学研究所, 助教
• From Oct. 2014, To Mar. 2015

  藤田保健衛生大学, 総合医科学研究所, 博士研究員
• From Apr. 2011, To Mar. 2014

  JSPS Research Fellow

Profile

• Profile

  現在の主要な研究テーマは2つあります。1つは、TRPチャネル（2021年ノーベル生理学・医学賞受賞）に関するテーマです。低酸素に対する生理的な反応は、秒～分単位の急性の応答と時間～日単位の緩徐な応答に大きく分類されます。慢性の低酸素応答である造血作用や血管形成などには、hypoxia-inducible factor (HIF：低酸素誘導因子)が中心的な役割を果たすことが知られています（2019年ノーベル生理学・医学賞受賞）。それに対し、急性の酸素センシングには頸動脈小体の発見以降（1938年ノーベル生理学・医学賞受賞）、頸動脈小体による血中酸素濃度感知が重要であるとされていますが、その分子メカニズムに関しては仮説が乱立しており混迷状態にあります。幸運なことに、頸動脈小体研究の第一人者であるJosé López-Barneo先生のラボで研究する機会に恵まれ、頸動脈小体研究の最前線に触れることができました。その経験とTRPチャネルに関するノウハウ及び知見を活かし、急性の酸素センシングの普遍的な分子メカニズムに迫ります。

  
  

  　もう1つは、電位依存性カルシウムチャネルに関するテーマです。近年、大規模なゲノムワイド関連解析により、電位依存性カルシウムチャネルサブユニットが統合失調症を含む精神疾患と関連することが次々と報告されていますが、発症メカニズム・病態にどのように関与するのかはよくわかっていません。興味深いことに電位依存性カルシウムチャネルサブユニットはイオン透過とは「異なる」機構を介して、様々な役割を有していることが明らかになりつつあります。そのユニークな機能が脳高次機能において果たす役割を明らかにしていきたいと考えています。

ID,URL

• ORCID ID

  0000-0002-2296-8245

• J-Global ID

  201101097117851060

• Researcher number

  30748926

researchmap URL

• https://researchmap.jp/nakaoakito

Research

Research Areas

• Life sciences, Neuroscience - general

Papers

• Universal roles of the TRPA1 channel in oxygen-sensing

  Akito Nakao; Ke Liu; Nobuaki Takahashi; Yasuo Mori

  Folia Pharmacologica Japonica, 01 May 2024, Lead author, Corresponding author

  
• Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

  Hideo Hagihara; Hirotaka Shoji; Satoko Hattori; Giovanni Sala; Yoshihiro Takamiya; Mika Tanaka; Masafumi Ihara; Mihiro Shibutani; Izuho Hatada; Kei Hori; Mikio Hoshino; Akito Nakao; Yasuo Mori; Shigeo Okabe; Masayuki Matsushita; Anja Urbach; Yuta Katayama; Akinobu Matsumoto; Keiichi I Nakayama; Shota Katori; Takuya Sato; Takuji Iwasato; Haruko Nakamura; Yoshio Goshima; Matthieu Raveau; Tetsuya Tatsukawa; Kazuhiro Yamakawa; Noriko Takahashi; Haruo Kasai; Johji Inazawa; Ikuo Nobuhisa; Tetsushi Kagawa; Tetsuya Taga; Mohamed Darwish; Hirofumi Nishizono; Keizo Takao; Kiran Sapkota; Kazutoshi Nakazawa; Tsuyoshi Takagi; Haruki Fujisawa; Yoshihisa Sugimura; Kyosuke Yamanishi; Lakshmi Rajagopal; Nanette Deneen Hannah; Herbert Y Meltzer; Tohru Yamamoto; Shuji Wakatsuki; Toshiyuki Araki; Katsuhiko Tabuchi; Tadahiro Numakawa; Hiroshi Kunugi; Freesia L Huang; Atsuko Hayata-Takano; Hitoshi Hashimoto; Kota Tamada; Toru Takumi; Takaoki Kasahara; Tadafumi Kato; Isabella A Graef; Gerald R Crabtree; Nozomi Asaoka; Hikari Hatakama; Shuji Kaneko; Takao Kohno; Mitsuharu Hattori; Yoshio Hoshiba; Ryuhei Miyake; Kisho Obi-Nagata; Akiko Hayashi-Takagi; Léa J Becker; Ipek Yalcin; Yoko Hagino; Hiroko Kotajima-Murakami; Yuki Moriya; Kazutaka Ikeda; Hyopil Kim; Bong-Kiun Kaang; Hikari Otabi; Yuta Yoshida; Atsushi Toyoda; Noboru H Komiyama; Seth GN Grant; Michiru Ida-Eto; Masaaki Narita; Ken-ichi Matsumoto; Emiko Okuda-Ashitaka; Iori Ohmori; Tadayuki Shimada; Kanato Yamagata; Hiroshi Ageta; Kunihiro Tsuchida; Kaoru Inokuchi; Takayuki Sassa; Akio Kihara; Motoaki Fukasawa; Nobuteru Usuda; Tayo Katano; Teruyuki Tanaka; Yoshihiro Yoshihara; Michihiro Igarashi; Takashi Hayashi; Kaori Ishikawa; Satoshi Yamamoto; Naoya Nishimura; Kazuto Nakada; Shinji Hirotsune; Kiyoshi Egawa; Kazuma Higashisaka; Yasuo Tsutsumi; Shoko Nishihara; Noriyuki Sugo; Takeshi Yagi; Naoto Ueno; Tomomi Yamamoto; Yoshihiro Kubo; Rie Ohashi; Nobuyuki Shiina; Kimiko Shimizu; Sayaka Higo-Yamamoto; Katsutaka Oishi; Hisashi Mori; Tamio Furuse; Masaru Tamura; Hisashi Shirakawa; Daiki X Sato; Yukiko U Inoue; Takayoshi Inoue; Yuriko Komine; Tetsuo Yamamori; Kenji Sakimura; Tsuyoshi Miyakawa

  eLife, 26 Mar. 2024, Peer-reviewed

  
• An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia

  Naoya Ieda; Masato Sawada; Runa Oguchi; Masato Itoh; Seina Hirakata; Daisuke Saitoh; Akito Nakao; Mitsuyasu Kawaguchi; Kazunobu Sawamoto; Toshitada Yoshihara; Yasuo Mori; Hidehiko Nakagawa

  Angewandte Chemie International Edition, 16 Mar. 2023, Peer-reviewed

  
• Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice

  Jörg Striessnig; Akito Nakao; Yasuo Mori

  Voltage-Gated Calcium Channels, Nov. 2022, Peer-reviewed, Invited

  
• Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca2+ uptake and susceptibility to epithelial barrier dysfunction

  Yasuo Mori; Mizuki Omori; Akito Nakao

  Cell Calcium, Nov. 2022, Peer-reviewed, Last author

  
• Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons.

  Tomoyuki Murano; Ryuichi Nakajima; Akito Nakao; Nao Hirata; Satoko Amemori; Akira Murakami; Yukiyasu Kamitani; Jun Yamamoto; Tsuyoshi Miyakawa

  Proceedings of the National Academy of Sciences of the United States of America, 09 Aug. 2022, Peer-reviewed

  
• Hippocampus-related cognitive disorders develop in the absence of epilepsy and ataxia in the heterozygous Cacna1a mutant mice tottering.

  Akito Nakao; Katsumi Hayashida; Hiroo Ogura; Yasuo Mori; Keiji Imoto

  Channels (Austin, Tex.), Dec. 2022, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation.

  Isato Fukushi; Kotaro Takeda; Mieczyslaw Pokorski; Yosuke Kono; Masashi Yoshizawa; Yohei Hasebe; Akito Nakao; Yasuo Mori; Hiroshi Onimaru; Yasumasa Okada

  Frontiers in physiology, Oct. 2021, Peer-reviewed

  
• Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders

  Akito Nakao; Yoshihiro Matsunaga; Katsumi Hayashida; Nobuaki Takahashi

  Frontiers in Cell and Developmental Biology, 11 Feb. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions

  Hideo Hagihara; Hirotaka Shoji; International Brain pH Project Consortium; Tsuyoshi Miyakawa

  bioRxiv, 03 Feb. 2021

  
• Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.

  Hieu Hoang Trung; Toru Yoshihara; Akito Nakao; Katsumi Hayashida; Yoshiki Hirata; Koumei Shirasuna; Mitsuru Kuwamura; Yuki Nakagawa; Takehito Kaneko; Yasuo Mori; Masahide Asano; Takashi Kuramoto

  Scientific reports, 21 Jan. 2021, Peer-reviewed

  Access this paper :

  
• O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

  *Makoto Uchiyama; *Akito Nakao; Yuki Kurita; Isato Fukushi; Kotaro Takeda; Tomohiro Numata; Ha Nam Tran; Seishiro Sawamura; Maximilian Ebert; Tatsuki Kurokawa; Reiko Sakaguchi; Alexander J. Stokes; Nobuaki Takahashi; Yasumasa Okada; Yasuo Mori *共同第一著者

  Current Biology, Jul. 2020, Peer-reviewed, Lead author

  
• Multiple types of navigational information are diffusely and independently encoded in the population activities of the dentate gyrus neurons

  Tomoyuki Murano; Ryuichi Nakajima; Akito Nakao; Nao Hirata; Satoko Amemori; Akira Murakami; Yukiyasu Kamitani; Jun Yamamoto; Tsuyoshi Miyakawa

  bioRxiv, 09 Jun. 2020

  
• Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders.

  Hagihara H; Catts VS; Katayama Y; Shoji H; Takagi T; Huang FL; Nakao A; Mori Y; Huang KP; Ishii S; Graef IA; Nakayama KI; Shannon Weickert C; Miyakawa T

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Feb. 2018, Peer-reviewed

  Access this paper :

  
• Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability

  Akito Nakao; Naoyuki Miyazaki; Koji Ohira; Hideo Hagihara; Tsuyoshi Takagi; Nobuteru Usuda; Shunsuke Ishii; Kazuyoshi Murata; Tsuyoshi Miyakawa

  Molecular Brain, Dec. 2017, Peer-reviewed, Lead author

  
• Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compoundss

  Seishiro Sawamura; Masahiko Hatano; Yoshinori Takada; Kyosuke Hino; Tetsuya Kawamura; Jun Tanikawa; Hiroshi Nakagawa; Hideharu Hase; Akito Nakao; Mitsuru Hirano; Rachapun Rotrattanadumrong; Shigeki Kiyonaka; Masayuki X. Mori; Motohiro Nishida; Yaopeng Hu; Ryuji Inoue; Ryu Nagata; Yasuo Mori

  Molecular Pharmacology, 01 Mar. 2016, Peer-reviewed

  
• Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice

  Akito Nakao; Takafumi Miki; Hirotaka Shoji; Miyuki Nishi; Hiroshi Takeshima; Tsuyoshi Miyakawa; Yasuo Mori

  Frontiers in Behavioral Neuroscience, 16 Jun. 2015, Peer-reviewed, Lead author

  Access this paper :

  
• Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering

  Akito Nakao; Takafumi Miki; Ken Shimono; Hiroaki Oka; Tomohiro Numata; Shigeki Kiyonaka; Kaori Matsushita; Hiroo Ogura; Tetsuhiro Niidome; Jeffrey L. Noebels; Minoru Wakamori; Keiji Imoto; Yasuo Mori

  Pflügers Archiv - European Journal of Physiology, Apr. 2015, Peer-reviewed, Lead author

  
• Molecular architecture of Ca2+ channel complexes organized by CaVβ subunits in presynaptic active zones.

  Akito Nakao; Mitsuru Hirano; Yoshinori Takada; Shigeki Kiyonaka; Yasuo Mori

  Modulation of presynaptic calcium channels, 2013, Peer-reviewed, Invited

  
• Calcium channels regulate neuronal function, gene expression, and development.

  Nakao A; Takada Y; Mori Y

  Brain and nerve = Shinkei kenkyu no shinpo, Jul. 2011, Invited

  
• Receptor Signaling Integration by TRP Channelsomes

  Yasuo Mori; Taketoshi Kajimoto; Akito Nakao; Nobuaki Takahashi; Shigeki Kiyonaka

  Transient Receptor Potential Channels, 2011, Peer-reviewed

  
• Rab3-interacting Molecule gamma Isoforms Lacking the Rab3-binding Domain Induce Long Lasting Currents but Block Neurotransmitter Vesicle Anchoring in Voltage-dependent P/Q-type Ca2+ Channels

  Yoshitsugu Uriu; Shigeki Kiyonaka; Takafumi Miki; Masakuni Yagi; Satoshi Akiyama; Emiko Mori; Akito Nakao; Aaron M. Beedle; Kevin P. Campbell; Minoru Wakamori; Yasuo Mori

  Journal of Biological Chemistry, Jul. 2010, Peer-reviewed

  Access this paper :

  

Misc.

• TRPA channel plays ubiquitous roles in O2 sensing

  Yasuo Mori; Akito Nakao; Ke Liu; Nobuaki Takahashi

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022

  
• Generation and analysis of voltage-gated calcium channel β4 subunit conditional knock-out mice

  Katsumi Hayashida; Akito Nakao; Toru Yoshihara; Masahide Asano; Yasuo Mori

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022

  
• The role of TRPA1 in hypoxic response of the carotid body

  Tomoya Kawamoto; Akito Nakao; Barneo José López; Yasuo Mori

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022

  
• Astrocytes mediate the post‐hypoxic persistent respiratory augmentation

  Isato Fukushi; Kotaro Takeda; Mieczyslaw Pokorski; Yosuke Kono; Masashi Yoshizawa; Yohei Hasebe; Akito Nakao; Yasuo Mori; Hiroshi Onimaru; Yasumasa Okada

  The FASEB Journal, 14 May 2021

  
• BARP regulates the dynamics of voltage-dependent Ca2+ channel complexes at dendritic spine

  Yoshihiro Matsunaga; Akito Nakao; Mizuki Omori; Taketoshi Kajimoto; Yasuo Mori

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021

  
• 酸素センシングにおけるRedox感受性TRPチャネル

  内山誠; 中尾章人

  医学のあゆみ, 2019, Invited

  
• Population coding of multiple types of information in dentate gyrus

  Ryuichi Nakajima; Tomoyuki Murano; Akito Nakao; Nao Hirata; Satoko Amemori; Akira Murakami; Yukiyasu Kamitani; Jun Yamamoto; Tsuyoshi Miyakawa

  IBRO Reports, Sep. 2019, Peer-reviewed

  
• Three-dimensional analysis of morphological changes in dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophrenia

  Nakao A

  Int. J. Neuropsychopharmacol., 2016, Peer-reviewed

  
• トランスポートソーム:トランスポーター・チャネル群の相互作用に基づく神経系の機能構築 神経伝達物質放出を支えるCa2+チャネルとシナプス小胞を繋ぐ動的複合体

  平野満; 中尾章人; 森誠之; 森泰生

  脳21, 2013, Invited

  
• 電位依存性チャネル

  若森実; 三木崇史; 中尾章人; 高田宜則; 森泰生

  脳神経科学イラストレイテッド 改訂第3版, 2013, Invited

  
• 電位依存性カルシウムチャネル

  澤村晴志朗; 中尾章人; 森泰生

  脳科学辞典（担当編集委員：林康紀）, 2013, Peer-reviewed, Invited

  
• Cholinergic induced oscillation in hippocampus of tottering Ca2+ channel mutant mice

  Akito Nakao; Takafumi Miki; Ken Shimono; Yasuo Mori

  Journal of Pharmacological Sciences, 2010, Peer-reviewed

  

External funds: Kakenhi

• 体性感覚認知における脳内酸素濃度変動及びその制御機構の生理的意義

  Grant-in-Aid for Early-Career Scientists

  Basic Section 46030:Function of nervous system-related

  Kyoto University

  中尾 章人

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  低酸素;イオンチャネル;酸素センシング;酸素;生体イメージング;神経系;低酸素環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15208/
• アストロサイトによる脳内酸素環境の恒常性維持機構

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  中尾 章人

  From 10 Sep. 2021, To 31 Mar. 2023, Granted

  アストロサイト;酸素;酸素センシング;イオンチャネル;低酸素環境;低酸素

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H05627/
• Investigation of schizophrenia-like behavioral phenotypes in mice with temporal regulation of calcineurin activity

  Grant-in-Aid for Young Scientists (B)

  Fujita Health University

  Akito Nakao

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  精神疾患;モデルマウス;行動解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18379/
• アストロサイトによる脳内酸素センシング機構

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  中尾 章人

  From 01 Apr. 2023, To 31 Mar. 2025, Granted

  低酸素;アストロサイト;TRPチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04164/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Analytical Chemistry II (Advanced Chemistry)

  7431, Spring, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Analysis of Life

  X605, Fall, Graduate School of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Analytical Chemistry II (Advanced Chemistry)

  7431, Spring, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamental Chemical Experiments

  N308, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Analytical Chemistry II (Advanced Chemistry)

  7431, Spring, Faculty of Engineering, 2
• From Apr. 2020, To Mar. 2021

  Analytical Chemistry II (Fundamental Chemistry)

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Analytical Chemistry II (Advanced Chemistry)

  Spring, 工学部