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Enomoto, Masato
Graduate School of Biostudies, Division of Systemic Life Science Assistant Professor
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Last Updated :2023/03/23
Basic Information
Affiliated programs (koza)
Faculty
Professional Memberships
Academic Degree
Research History
- From Apr. 2017, To Present京都大学大学院, 生命科学研究科・ システム機能学分野, 助教
- From Jun. 2013, To Mar. 2017京都大学大学院, 生命科学研究科・ システム機能学分野, 特定助教
- From Mar. 2013, To Jun. 2013京都大学大学院, 生命科学研究科・ システム機能学分野, 日本学術振興会特別研究員PD
- From Apr. 2012, To Mar. 2013神戸大学大学院, 医学研究科・遺伝学分野, 日本学術振興会特別研究員PD
- From Apr. 2010, To Mar. 2012神戸大学大学院, 医学研究科・細胞生物学G-COE, 学術研究員
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Last Updated :2023/03/23
Research
Research Topics, Overview of the research
Research Topics
Elucidating the mechanisms of tissue homeostasis and tumorigenesis via cell-cell interactionOverview of the research
Cell-cell interaction is important for maintenance of tissue homeostasis and its dysregulation links to cancer progression. However, the mechanisms of how individual cell interacts with each other and maintains tissue homeostasis is poorly understood yet. To elucidate this, I will analyze the mechanisms by which cell-cell communication among epithelial cell, dying cell and macrophage drives tissue repair and tumor progression.
Research Interests
Research Areas
Papers
- Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in DrosophilaMasato Enomoto; Daisaku Takemoto; Tatsushi IgakiDevelopmental Cell, Aug. 2021, Peer-reviewed, Lead author, Corresponding author
- Drosophila as a cancer modelMasato Enomoto, Carmen Siow, Tatsushi IgakiAdvances in Experimental Medicine and Biology, Jun. 2018, Peer-reviewed, Invited, Lead author
- 細胞競合と代償性増殖におけるJNKシグナルの役割榎本将人生体の科学, 2016
- Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesisMasato Enomoto; John Vaughen; Tatsushi IgakiCancer Science, Dec. 2015, Peer-reviewed, Invited, Lead author
- JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activityMasato Enomoto; Daisuke Kizawa; Shizue Ohsawa; Tatsushi IgakiDevelopmental Biology, Jul. 2015, Peer-reviewed, Lead author
- 細胞の協調と競合におけるHippo経路の役割榎本将人; 井垣 達吏医学のあゆみ, 2014
- がんの発生・進展を促すニッチ細胞榎本将人; 井垣 達吏実験医学, 2014
- Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in DrosophilaMasato Enomoto; Tatsushi IgakiEMBO Reports, Jan. 2013, Peer-reviewed, Lead author
- Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in DrosophilaShizue Ohsawa; Yoshitaka Sato; Masato Enomoto; Mai Nakamura; Aya Betsumiya; Tatsushi IgakiNature, Oct. 2012, Peer-reviewed
- Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cellsAkihito Inoko; Makoto Matsuyama; Hidemasa Goto; Yuki Ohmuro-Matsuyama; Yuko Hayashi; Masato Enomoto; Miho Ibi; Takeshi Urano; Shigenobu Yonemura; Tohru Kiyono; Ichiro Izawa; Masaki InagakiJournal of Cell Biology, Apr. 2012, Peer-reviewed
- Deciphering tumor-suppressor signaling in flies: Genetic link between Scribble/Dlg/Lgl and the Hippo pathwaysMasato Enomoto; Tatsushi IgakiJournal of Genetics and Genomics, Oct. 2011, Peer-reviewed, Lead author
- Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.Miho Ibi; Peng Zou; Akihito Inoko; Takashi Shiromizu; Makoto Matsuyama; Yuko Hayashi; Masato Enomoto; Daisuke Mori; Shinji Hirotsune; Tohru Kiyono; Sachiko Tsukita; Hidemasa Goto; Masaki InagakiJournal of Cell Science, 15 Mar. 2011, Peer-reviewed
- 14-3-3 gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageKousuke Kasahara; Hidemasa Goto; Masato Enomoto; Yasuko Tomono; Tohru Kiyono; Masaki InagakiEMBO Journal, Aug. 2010, Peer-reviewed
- Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M TransitionMasato Enomoto; Hidemasa Goto; Yasuko Tomono; Kousuke Kasahara; Kunio Tsujimura; Tohru Kiyono; Masaki InagakiJournal of Biological Chemistry, Dec. 2009, Peer-reviewed, Lead author
- Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulationYosuke Ikegami; Hidemasa Goto; Tohru Kiyono; Masato Enomoto; Kousuke Kasahara; Yasuko Tomono; Keiichi Tozawa; Akimichi Morita; Kenjiro Kohri; Masaki InagakiBiochemical and Biophysical Research Communications, Dec. 2008, Peer-reviewed
- Biochemical characterization of suramin as a selective inhibitor for the PKA-mediated phosphorylation of HBV core protein in vitroMotohito Okabe; Masato Enomoto; Haruki Maeda; Kazuyuki Kuroki; Kenzo OhtsukiBiological and Pharmaceutical Bulletin, Sep. 2006, Peer-reviewed
- High phosphorylation of HBV core protein by two alpha-type CK2-activated cAMP-dependent protein kinases in vitroMasato Enomoto; Yoshitaka Sawano; Seiji Kosuge; Yuko Yamano; Kazuyuki Kuroki; Kenzo OhtsukiFEBS Letters, Feb. 2006, Peer-reviewed, Lead author
Misc.
- 分裂前期及びDNA損傷により起こるChk1新規リン酸化反応(Novel Chk1 phosphorylation occurred not only in early mitosis but also in DNA damage checkpoint)池上 要介; 後藤 英仁; 榎本 将人; 笠原 広介; 友野 靖子; 辻村 邦夫; 清野 透; 森田 明理; 郡 健二郎; 稲垣 昌樹日本癌学会総会記事, Aug. 2007
Presentations
- JNKシグナルの細胞間伝播を介した上皮組織修復の時空間制御榎本 将人; 井垣 達吏第74回日本細胞生物学会大会, 28 Jun. 2022
- Interaction of distinct tumor cells causes interdependent tumor malignancy via Notch signaling榎本 将人; 竹本 大策; 井垣 達吏第44回日本分子生物学会年会, 02 Dec. 2021
- Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling榎本 将人; 竹本 大策; 井垣 達吏第14回日本ショウジョウバエ研究会, 13 Sep. 2021
- JNK依存的なHippo経路活性スイッチによる腫瘍成長制御榎本 将人; 木澤 大輔; 井垣 達吏第36回日本分子生物学会年会, 03 Dec. 2013, Invited
- Genetic dissection of epithelial tissue remodeling via cell-cell communications.Masato Enomoto; Tatsushi Igaki第73回日本細胞生物学会大会, 29 Jun. 2021, Invited
- Spatiotemporal regulation of tissue repair via cell-cell communication榎本 将人; 井垣 達吏第72日本細胞生物学会大会, Jun. 2020
- Cell-to-cell propagation of JNK signaling controls tissue remodeling during wound healing榎本 将人; 井垣 達吏第13回日本ショウジョウバエ研究会, 11 Sep. 2018
- Cell-to-cell propagation of JNK signaling controls tissue repair and regeneration榎本 将人; 井垣 達吏第70回日本細胞生物学会大会, 06 Jun. 2018
- 細胞間シグナルネットワークによる創傷治癒制御榎本 将人第３回京都皮膚基礎研究会, Mar. 2018, Invited
- 細胞間コミュニケーションによるがん進展制御榎本 将人; 本田 直樹; 武本 花奈美; 竹本 大策; 井垣 達吏生命科学系学会合同年次大会, 09 Dec. 2017
- Src controls tumor microenvironment via Adam-mediated cell-to-cell propagation of JNK signaling榎本 将人; 井垣 達吏第76回日本癌学会学術総会, 29 Sep. 2017
- 死細胞が発信する細胞間シグナルネットワークによる創傷治癒制御榎本 将人; 井垣 達吏第26回日本Cell Death学会学術集会, 25 Jul. 2017
- Src drives cell-to-cell propagation of JNK signaling to control tumorigenesis and regeneration.榎本 将人日本発生生物学会 秋季シンポジウム2016, 19 Oct. 2016, Invited
- Genetic and mathematical dissection of tumor heterogeneity that triggers cancer progression榎本 将人; 本田 直樹; 竹本 大策; 井垣 達吏第12回日本ショウジョウバエ研究会, 10 Sep. 2016
- がん遺伝子活性の不均一性による腫瘍悪性化榎本 将人; 竹本 大策; 井垣 達吏第68回日本細胞生物学会・第11回日本ケミカルバイオロジー学会 合同大会, 17 Jun. 2016
- Tumor progression by heterogeneity of cell clones with distinct oncogenic activitiesEnomoto MThe 2nd Cell competition International symposium, Apr. 2016, Invited
- がん遺伝子活性の不均一性による腫瘍悪性化の分子基盤榎本 将人; 竹本 大策; 井垣 達吏第67回日本細胞生物学会大会, 30 Jun. 2015
- Tumor progression by a genetic heterogeneity of cell clones with distinct oncogenic activitiesEnomoto M; Takemoto D; Igaki T56th Annual Drosophila Research Conference, workshop, 07 Mar. 2015
- Tumor growth regulation by JNK-dependent switching of the Hippo pathway activity榎本 将人; 木澤 大輔; 井垣 達吏第11回日本ショウジョウバエ研究会, 06 Jun. 2014
- Src controls tumorigenesis through JNK-dependent regulation of the Hippo pathwayEnomoto M; Igaki T54th Annual Drosophila Research Conference, workshop, 05 Apr. 2013
- SrcによるJNK依存的なHippo経路制御を介した腫瘍形成機構榎本 将人大阪大学蛋白研セミナー「キナーゼ・シグナリング研究の進展」, 15 Mar. 2014, Invited
- Src controls tumorigenesis through JNK-dependent Hippo pathway regulation in Drosophila.榎本 将人; 井垣 達吏第35回日本分子生物学会年会, ワークショップ, 13 Dec. 2012
- Src controls tumorigenesis through JNK-dependent Hippo pathway regulation in Drosophila榎本 将人, 井垣 達吏第10回ショウジョウバエ研究会, 13 Oct. 2012
- Src, a novel super-competitor in Drosophila榎本 将人, 井垣 達吏第34回日本分子生物学会年会, ワークショップ, 13 Dec. 2011, Invited
- Biochemical characterization and the biological significance of the CK2-activated alpha-type cAMP-dependent protein kinases (CK2-aPKAs) in vitroM Enomoto; Y Sawano; S Kosuge; Y Yamano; K Kuroki; K OhtsukiFEBS JOURNAL, Jul. 2005, BLACKWELL PUBLISHING
Books and Other Publications
- 細胞競合によるがん制御細胞競合によるがん制御細胞死(化学同人), DOJIN BIOSCIENCE SERIES 33, p.125-136, Aug. 2019
- 細胞周期とがん榎本 将人; 井垣 達吏京大発！フロンティア生命科学 pp.157-168, 講談社, Mar. 2018, Not refereed
- がんの発生・進展機構の解明と治療薬開発への応用辻椋矢; 榎本 将人物／疾患モデルの作製技術・病態解析・評価手法 pp.147-153, 技術情報協会, Aug. 2017, Not refereed
Awards
External funds: Kakenhi
- 組織修復の時空間制御を司るシンギュラリティ細胞の解析Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Complex systemsKyoto University榎本 将人From 01 Apr. 2021, To 31 Mar. 2023, Granted組織修復;シグナル伝達;ショウジョウバエ;細胞間相互作用;少数細胞;Zfh1/ZEB1;修復;再生
- 上皮の概日時計ネットワークによる組織恒常性の制御Grant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 48:Biomedical structure and function and related fieldsKyoto University榎本 将人From 30 Jul. 2020, To 31 Mar. 2023, Granted上皮;概日時計;がん;シグナル伝達;ショウジョウバエ;組織恒常性
- Elucidation of the mechanisms of tissue repair by the spatio-temporal regulation of cell deathGrant-in-Aid for Scientific Research (B)Basic Section 48040:Medical biochemistry-relatedKyoto UniversityMasato EnomotoFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed細胞死;細胞間相互作用;組織間相互作用;組織修復;ショウジョウバエ;生体損傷;貪食;細胞間コミュニケーション;組織間コミュニケーション
- Elucidating the mechanism of cancer cell evolution via cell-cell interactionGrant-in-Aid for Challenging Research (Exploratory)Kyoto UniversityMasato EnomotoFrom 30 Jun. 2017, To 31 Mar. 2020, Project Closedがん;細胞間相互作用;Ras;Src;細胞融合;細胞肥大化;シグナル伝達;細胞間コミュニケーション
- 死細胞が残した細胞間シグナルネットワークを介した創傷治癒制御Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Biological SciencesKyoto University榎本 将人From 01 Apr. 2017, To 31 Mar. 2019, Project Closed死細胞;細胞間コミュニケーション;創傷治癒;シグナル伝達;JNKシグナル
- Genetic basis of cancer progression by dying tumor cellsGrant-in-Aid for Young Scientists (A)Kyoto UniversityMasato EnomotoFrom 01 Apr. 2016, To 31 Mar. 2019, Project Closedがん;死細胞;シグナル伝達;ショウジョウバエ;細胞間相互作用;腫瘍内不均一性;代償性増殖;細胞死;細胞間コミュニケーション;癌
- Tumor growth regulation by switching JNK-dependent Hippo signaling regulationGrant-in-Aid for Challenging Exploratory ResearchKyoto UniversityMasato ENOMOTOFrom 01 Apr. 2014, To 31 Mar. 2016, Project Closed細胞競合;適応度;JNK;Hippo経路;がん;JNKシグナル;細胞適応度;がん進展
- 細胞間コミュニケーションを介した細胞非自律的な腫瘍悪性化の分子基盤Grant-in-Aid for Young Scientists (B)Kobe University榎本 将人From 01 Apr. 2011, To 31 Mar. 2012, DiscontinuedRNAプロセッシング;Rasシグナル;細胞非自律的増殖;細胞間コミュニケーション
- Molecular and Cellular Basis of Tumor Invasion at The Tissue-Intrinsic MicroenvironmentGrant-in-Aid for Scientific Research (B)Basic Section 48040:Medical biochemistry-relatedKyoto University田守 洋一郎From 01 Apr. 2022, To 31 Mar. 2026, Granted腫瘍浸潤;発がん;がん微小環境;ゲノム倍数性;ショウジョウバエ
External funds: others
list
Last Updated :2023/03/23
Education
Teaching subject(s)
- From 01 Apr. 2022, To 31 Mar. 2023Advanced Course in Studies on Signal Transduction1029, Fall, Graduate School of Biostudies, 1
- From 01 Apr. 2022, To 31 Mar. 2023Biological Chemistry 5 (Cell Biology)A205, Fall, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023Biological Chemistry V (Cell Biology)C205, Fall, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023ILAS SeminarZ001, Spring, Institute for Liberal Arts and Sciences, 2
- From Apr. 2014, To Mar. 2015Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2014, To Mar. 2015Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2015, To Mar. 2016Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2015, To Mar. 2016Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2016, To Mar. 2017Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2016, To Mar. 2017Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2017, To Mar. 2018Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2017, To Mar. 2018Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2018, To Mar. 2019Advanced Course in Studies on Signal TransductionSpring, 生命科学研究科
- From Apr. 2018, To Mar. 2019Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2018, To Mar. 2019Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2019, To Mar. 2020Advanced Course in Studies on Signal TransductionFall, 生命科学研究科
- From Apr. 2019, To Mar. 2020Biological Chemistry V (Cell Biology)Fall, 薬学部
- From Apr. 2019, To Mar. 2020Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2019, To Mar. 2020Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2020, To Mar. 2021Advanced Course in Studies on Signal TransductionSpring, 生命科学研究科
- From Apr. 2020, To Mar. 2021Biological Chemistry V (Cell Biology)Fall, 薬学部
- From Apr. 2020, To Mar. 2021Biological Chemistry 5 (Cell Biology)Fall, 薬学部
- From Apr. 2020, To Mar. 2021Pharmaceutical Laboratory IV : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2020, To Mar. 2021Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyFall, 薬学部
- From Apr. 2021, To Mar. 2022ILAS Seminar : Mechanism of cancer - Basic research using Drosophila geneticsSpring, 全学共通科目
- From Apr. 2021, To Mar. 2022Advanced Course in Studies on Signal TransductionSpring, 生命科学研究科
- From Apr. 2021, To Mar. 2022Biological Chemistry V (Cell Biology)Fall, 薬学部
- From Apr. 2021, To Mar. 2022Biological Chemistry 5 (Cell Biology)Fall, 薬学部
