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Enomoto, Masato

Graduate School of Biostudies, Division of Systemic Life Science Assistant Professor

Enomoto, Masato
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    Last Updated :2023/01/25

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Pharmaceutical Sciences, 薬科学専攻 生体機能薬学講座, 助教

    Faculty

    • 薬学部

    Professional Memberships

    • 日本生化学会
    • 日本Cell Death学会
    • 日本癌学会
    • 日本細胞生物学会
    • 日本分子生物学会

    Academic Degree

    • 修士(医科学)(北里大学)
    • 博士(医学)(名古屋大学)

    Research History

    • From Apr. 2017, To Present
      京都大学大学院, 生命科学研究科・ システム機能学分野, 助教
    • From Jun. 2013, To Mar. 2017
      京都大学大学院, 生命科学研究科・ システム機能学分野, 特定助教
    • From Mar. 2013, To Jun. 2013
      京都大学大学院, 生命科学研究科・ システム機能学分野, 日本学術振興会特別研究員PD
    • From Apr. 2012, To Mar. 2013
      神戸大学大学院, 医学研究科・遺伝学分野, 日本学術振興会特別研究員PD
    • From Apr. 2010, To Mar. 2012
      神戸大学大学院, 医学研究科・細胞生物学G-COE, 学術研究員

    ID,URL

    researchmap URL

    list
      Last Updated :2023/01/25

      Research

      Research Topics, Overview of the research

      • Research Topics

        Elucidating the mechanisms of tissue homeostasis and tumorigenesis via cell-cell interaction
      • Overview of the research

        Cell-cell interaction is important for maintenance of tissue homeostasis and its dysregulation links to cancer progression. However, the mechanisms of how individual cell interacts with each other and maintains tissue homeostasis is poorly understood yet. To elucidate this, I will analyze the mechanisms by which cell-cell communication among epithelial cell, dying cell and macrophage drives tissue repair and tumor progression.

      Research Interests

      • ショウジョウバエ
      • 臓器連関
      • 細胞間相互作用
      • がん
      • 再生
      • 組織修復

      Research Areas

      • Life sciences, Tumor biology
      • Life sciences, Genetics
      • Life sciences, Cell biology

      Papers

      • Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila
        Masato Enomoto; Daisaku Takemoto; Tatsushi Igaki
        Developmental Cell, Aug. 2021, Peer-reviewed, Lead author, Corresponding author
      • Drosophila as a cancer model
        Masato Enomoto, Carmen Siow, Tatsushi Igaki
        Advances in Experimental Medicine and Biology, Jun. 2018, Peer-reviewed, Invited, Lead author
      • 細胞競合と代償性増殖におけるJNKシグナルの役割
        榎本将人
        生体の科学, 2016
      • Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis
        Masato Enomoto; John Vaughen; Tatsushi Igaki
        Cancer Science, Dec. 2015, Peer-reviewed, Invited, Lead author
      • JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity
        Masato Enomoto; Daisuke Kizawa; Shizue Ohsawa; Tatsushi Igaki
        Developmental Biology, Jul. 2015, Peer-reviewed, Lead author
      • 細胞の協調と競合におけるHippo経路の役割
        榎本将人; 井垣 達吏
        医学のあゆみ, 2014
      • がんの発生・進展を促すニッチ細胞
        榎本将人; 井垣 達吏
        実験医学, 2014
      • Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila
        Masato Enomoto; Tatsushi Igaki
        EMBO Reports, Jan. 2013, Peer-reviewed, Lead author
      • Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila
        Shizue Ohsawa; Yoshitaka Sato; Masato Enomoto; Mai Nakamura; Aya Betsumiya; Tatsushi Igaki
        Nature, Oct. 2012, Peer-reviewed
      • Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells
        Akihito Inoko; Makoto Matsuyama; Hidemasa Goto; Yuki Ohmuro-Matsuyama; Yuko Hayashi; Masato Enomoto; Miho Ibi; Takeshi Urano; Shigenobu Yonemura; Tohru Kiyono; Ichiro Izawa; Masaki Inagaki
        Journal of Cell Biology, Apr. 2012, Peer-reviewed
      • Deciphering tumor-suppressor signaling in flies: Genetic link between Scribble/Dlg/Lgl and the Hippo pathways
        Masato Enomoto; Tatsushi Igaki
        Journal of Genetics and Genomics, Oct. 2011, Peer-reviewed, Lead author
      • Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
        Miho Ibi; Peng Zou; Akihito Inoko; Takashi Shiromizu; Makoto Matsuyama; Yuko Hayashi; Masato Enomoto; Daisuke Mori; Shinji Hirotsune; Tohru Kiyono; Sachiko Tsukita; Hidemasa Goto; Masaki Inagaki
        Journal of Cell Science, 15 Mar. 2011, Peer-reviewed
      • 14-3-3 gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
        Kousuke Kasahara; Hidemasa Goto; Masato Enomoto; Yasuko Tomono; Tohru Kiyono; Masaki Inagaki
        EMBO Journal, Aug. 2010, Peer-reviewed
      • Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M Transition
        Masato Enomoto; Hidemasa Goto; Yasuko Tomono; Kousuke Kasahara; Kunio Tsujimura; Tohru Kiyono; Masaki Inagaki
        Journal of Biological Chemistry, Dec. 2009, Peer-reviewed, Lead author
      • Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation
        Yosuke Ikegami; Hidemasa Goto; Tohru Kiyono; Masato Enomoto; Kousuke Kasahara; Yasuko Tomono; Keiichi Tozawa; Akimichi Morita; Kenjiro Kohri; Masaki Inagaki
        Biochemical and Biophysical Research Communications, Dec. 2008, Peer-reviewed
      • Biochemical characterization of suramin as a selective inhibitor for the PKA-mediated phosphorylation of HBV core protein in vitro
        Motohito Okabe; Masato Enomoto; Haruki Maeda; Kazuyuki Kuroki; Kenzo Ohtsuki
        Biological and Pharmaceutical Bulletin, Sep. 2006, Peer-reviewed
      • High phosphorylation of HBV core protein by two alpha-type CK2-activated cAMP-dependent protein kinases in vitro
        Masato Enomoto; Yoshitaka Sawano; Seiji Kosuge; Yuko Yamano; Kazuyuki Kuroki; Kenzo Ohtsuki
        FEBS Letters, Feb. 2006, Peer-reviewed, Lead author

      Misc.

      • 分裂前期及びDNA損傷により起こるChk1新規リン酸化反応(Novel Chk1 phosphorylation occurred not only in early mitosis but also in DNA damage checkpoint)
        池上 要介; 後藤 英仁; 榎本 将人; 笠原 広介; 友野 靖子; 辻村 邦夫; 清野 透; 森田 明理; 郡 健二郎; 稲垣 昌樹
        日本癌学会総会記事, Aug. 2007

      Presentations

      • JNKシグナルの細胞間伝播を介した上皮組織修復の時空間制御
        榎本 将人; 井垣 達吏
        第74回日本細胞生物学会大会, 28 Jun. 2022
      • Interaction of distinct tumor cells causes interdependent tumor malignancy via Notch signaling
        榎本 将人; 竹本 大策; 井垣 達吏
        第44回日本分子生物学会年会, 02 Dec. 2021
      • Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling
        榎本 将人; 竹本 大策; 井垣 達吏
        第14回日本ショウジョウバエ研究会, 13 Sep. 2021
      • JNK依存的なHippo経路活性スイッチによる腫瘍成長制御
        榎本 将人; 木澤 大輔; 井垣 達吏
        第36回日本分子生物学会年会, 03 Dec. 2013, Invited
      • Genetic dissection of epithelial tissue remodeling via cell-cell communications.
        Masato Enomoto; Tatsushi Igaki
        第73回日本細胞生物学会大会, 29 Jun. 2021, Invited
      • Spatiotemporal regulation of tissue repair via cell-cell communication
        榎本 将人; 井垣 達吏
        第72日本細胞生物学会大会, Jun. 2020
      • Cell-to-cell propagation of JNK signaling controls tissue remodeling during wound healing
        榎本 将人; 井垣 達吏
        第13回日本ショウジョウバエ研究会, 11 Sep. 2018
      • Cell-to-cell propagation of JNK signaling controls tissue repair and regeneration
        榎本 将人; 井垣 達吏
        第70回日本細胞生物学会大会, 06 Jun. 2018
      • 細胞間シグナルネットワークによる創傷治癒制御
        榎本 将人
        第3回京都皮膚基礎研究会, Mar. 2018, Invited
      • 細胞間コミュニケーションによるがん進展制御
        榎本 将人; 本田 直樹; 武本 花奈美; 竹本 大策; 井垣 達吏
        生命科学系学会合同年次大会, 09 Dec. 2017
      • Src controls tumor microenvironment via Adam-mediated cell-to-cell propagation of JNK signaling
        榎本 将人; 井垣 達吏
        第76回日本癌学会学術総会, 29 Sep. 2017
      • 死細胞が発信する細胞間シグナルネットワークによる創傷治癒制御
        榎本 将人; 井垣 達吏
        第26回日本Cell Death学会学術集会, 25 Jul. 2017
      • Src drives cell-to-cell propagation of JNK signaling to control tumorigenesis and regeneration.
        榎本 将人
        日本発生生物学会 秋季シンポジウム2016, 19 Oct. 2016, Invited
      • Genetic and mathematical dissection of tumor heterogeneity that triggers cancer progression
        榎本 将人; 本田 直樹; 竹本 大策; 井垣 達吏
        第12回日本ショウジョウバエ研究会, 10 Sep. 2016
      • がん遺伝子活性の不均一性による腫瘍悪性化
        榎本 将人; 竹本 大策; 井垣 達吏
        第68回日本細胞生物学会・第11回日本ケミカルバイオロジー学会 合同大会, 17 Jun. 2016
      • Tumor progression by heterogeneity of cell clones with distinct oncogenic activities
        Enomoto M
        The 2nd Cell competition International symposium, Apr. 2016, Invited
      • がん遺伝子活性の不均一性による腫瘍悪性化の分子基盤
        榎本 将人; 竹本 大策; 井垣 達吏
        第67回日本細胞生物学会大会, 30 Jun. 2015
      • Tumor progression by a genetic heterogeneity of cell clones with distinct oncogenic activities
        Enomoto M; Takemoto D; Igaki T
        56th Annual Drosophila Research Conference, workshop, 07 Mar. 2015
      • Tumor growth regulation by JNK-dependent switching of the Hippo pathway activity
        榎本 将人; 木澤 大輔; 井垣 達吏
        第11回日本ショウジョウバエ研究会, 06 Jun. 2014
      • Src controls tumorigenesis through JNK-dependent regulation of the Hippo pathway
        Enomoto M; Igaki T
        54th Annual Drosophila Research Conference, workshop, 05 Apr. 2013
      • SrcによるJNK依存的なHippo経路制御を介した腫瘍形成機構
        榎本 将人
        大阪大学蛋白研セミナー「キナーゼ・シグナリング研究の進展」, 15 Mar. 2014, Invited
      • Src controls tumorigenesis through JNK-dependent Hippo pathway regulation in Drosophila.
        榎本 将人; 井垣 達吏
        第35回日本分子生物学会年会, ワークショップ, 13 Dec. 2012
      • Src controls tumorigenesis through JNK-dependent Hippo pathway regulation in Drosophila
        榎本 将人, 井垣 達吏
        第10回ショウジョウバエ研究会, 13 Oct. 2012
      • Src, a novel super-competitor in Drosophila
        榎本 将人, 井垣 達吏
        第34回日本分子生物学会年会, ワークショップ, 13 Dec. 2011, Invited
      • Biochemical characterization and the biological significance of the CK2-activated alpha-type cAMP-dependent protein kinases (CK2-aPKAs) in vitro
        M Enomoto; Y Sawano; S Kosuge; Y Yamano; K Kuroki; K Ohtsuki
        FEBS JOURNAL, Jul. 2005, BLACKWELL PUBLISHING
      • 細胞競合によるがん制御
        細胞競合によるがん制御
        細胞死(化学同人), DOJIN BIOSCIENCE SERIES 33, p.125-136, Aug. 2019
      • 細胞周期とがん
        榎本 将人; 井垣 達吏
        京大発!フロンティア生命科学 pp.157-168, 講談社, Mar. 2018, Not refereed
      • がんの発生・進展機構の解明と治療薬開発への応用
        辻椋矢; 榎本 将人
        物/疾患モデルの作製技術・病態解析・評価手法 pp.147-153, 技術情報協会, Aug. 2017, Not refereed

      Awards

      • Jul. 2015
        日本細胞生物学会, 第67回日本細胞生物学会 若手優秀発表賞
      • Sep. 2018
        日本ショウジョウバエ研究会, The 9th Daigoro Moriwaki Award

      External funds: Kakenhi

      • 組織修復の時空間制御を司るシンギュラリティ細胞の解析
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        榎本 将人
        From 01 Apr. 2021, To 31 Mar. 2023, Granted
        組織修復;シグナル伝達;ショウジョウバエ;細胞間相互作用;少数細胞;Zfh1/ZEB1;修復;再生
      • 上皮の概日時計ネットワークによる組織恒常性の制御
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 48:Biomedical structure and function and related fields
        Kyoto University
        榎本 将人
        From 30 Jul. 2020, To 31 Mar. 2023, Granted
        上皮;概日時計;がん;シグナル伝達;ショウジョウバエ;組織恒常性
      • Elucidation of the mechanisms of tissue repair by the spatio-temporal regulation of cell death
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        Masato Enomoto
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        細胞死;細胞間相互作用;組織間相互作用;組織修復;ショウジョウバエ;生体損傷;貪食;細胞間コミュニケーション;組織間コミュニケーション
      • Elucidating the mechanism of cancer cell evolution via cell-cell interaction
        Grant-in-Aid for Challenging Research (Exploratory)
        Kyoto University
        Masato Enomoto
        From 30 Jun. 2017, To 31 Mar. 2020, Project Closed
        がん;細胞間相互作用;Ras;Src;細胞融合;細胞肥大化;シグナル伝達;細胞間コミュニケーション
      • 死細胞が残した細胞間シグナルネットワークを介した創傷治癒制御
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        榎本 将人
        From 01 Apr. 2017, To 31 Mar. 2019, Project Closed
        死細胞;細胞間コミュニケーション;創傷治癒;シグナル伝達;JNKシグナル
      • Genetic basis of cancer progression by dying tumor cells
        Grant-in-Aid for Young Scientists (A)
        Kyoto University
        Masato Enomoto
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        がん;死細胞;シグナル伝達;ショウジョウバエ;細胞間相互作用;腫瘍内不均一性;代償性増殖;細胞死;細胞間コミュニケーション;癌
      • Tumor growth regulation by switching JNK-dependent Hippo signaling regulation
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Masato ENOMOTO
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        細胞競合;適応度;JNK;Hippo経路;がん;JNKシグナル;細胞適応度;がん進展
      • 細胞間コミュニケーションを介した細胞非自律的な腫瘍悪性化の分子基盤
        Grant-in-Aid for Young Scientists (B)
        Kobe University
        榎本 将人
        From 01 Apr. 2011, To 31 Mar. 2012, Discontinued
        RNAプロセッシング;Rasシグナル;細胞非自律的増殖;細胞間コミュニケーション
      • Molecular and Cellular Basis of Tumor Invasion at The Tissue-Intrinsic Microenvironment
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        田守 洋一郎
        From 01 Apr. 2022, To 31 Mar. 2026, Granted
        腫瘍浸潤;発がん;がん微小環境;ゲノム倍数性;ショウジョウバエ

      External funds: others

      • 組織修復を駆動する組織微小環境ネットワーク
        JST, PRESTO
        From 01 Oct. 2021, To 31 Mar. 2025
      list
        Last Updated :2023/01/25

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Course in Studies on Signal Transduction
          1029, Fall, Graduate School of Biostudies, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Biological Chemistry 5 (Cell Biology)
          A205, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Biological Chemistry V (Cell Biology)
          C205, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          ILAS Seminar
          Z001, Spring, Institute for Liberal Arts and Sciences, 2
        • From Apr. 2014, To Mar. 2015
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2014, To Mar. 2015
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2015, To Mar. 2016
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2015, To Mar. 2016
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2016, To Mar. 2017
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2016, To Mar. 2017
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2017, To Mar. 2018
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2017, To Mar. 2018
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2018, To Mar. 2019
          Advanced Course in Studies on Signal Transduction
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2018, To Mar. 2019
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Advanced Course in Studies on Signal Transduction
          Fall, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Biological Chemistry V (Cell Biology)
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Advanced Course in Studies on Signal Transduction
          Spring, 生命科学研究科
        • From Apr. 2020, To Mar. 2021
          Biological Chemistry V (Cell Biology)
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Pharmaceutical Laboratory IV : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          ILAS Seminar : Mechanism of cancer - Basic research using Drosophila genetics
          Spring, 全学共通科目
        • From Apr. 2021, To Mar. 2022
          Advanced Course in Studies on Signal Transduction
          Spring, 生命科学研究科
        • From Apr. 2021, To Mar. 2022
          Biological Chemistry V (Cell Biology)
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Biological Chemistry 5 (Cell Biology)
          Fall, 薬学部

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