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Irie, Kazuhiro

Graduate School of Agriculture, Division of Food Science and Biotechnology Professor

Irie, Kazuhiro
list
    Last Updated :2022/10/02

    Basic Information

    Faculty

    • 農学部

    Email Address

    • Email Address

      irie.kazuhiro.2zkyoto-u.ac.jp

    Professional Memberships

    • The Japanese Peptide Society
    • Japanese Cancer Association
    • The Chemical Society of Japan
    • Japan Society for Bioscience, Biotechnology, and Agrochemistry
    • American Chemical Society

    Academic Degree

    • 農学修士(京都大学)
    • 農学博士(京都大学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院農学研究科修士課程食品工学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 農学部食品工学科, 卒業

    High School

    • High School

      自由学園高等科(東京都東久留米市)

    Research History

    • From Jul. 2007
      京都大学 教授(農学研究科食品生物科学専攻)
    • From Apr. 2001, To Jun. 2007
      京都大学 助教授(農学研究科食品生物科学専攻)
    • From Apr. 1999, To Mar. 2001
      京都大学 助教授(農学研究科応用生命科学専攻)
    • From Apr. 1998, To Mar. 1999
      京都大学 助手(農学研究科応用生命科学専攻)
    • From Apr. 1984, To Mar. 1997
      京都大学 助手(農学部食品工学科)
    • From Apr. 1992, To Mar. 1993
      米国スタンフォード大学化学科客員研究員(Paul A. Wender教授)

    Profile

    • Profile

      1982年京都大学農学部食品工学科卒業、1984年同大学大学院農学研究科修士課程修了、同年京都大学農学部助手、1988年農学博士、1999年京都大学大学院農学研究科応用生命科学専攻助教授、2007年同大学院同研究科食品生物科学専攻教授、現在に至る.この間、1992年4月から1年間、米国スタンフォード大学化学科客員研究員(Paul A. Wender教授) 趣味:化石および鉱物の収集、ランの栽培

    Language of Instruction

    • English

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2022/10/02

      Research

      Research Topics, Overview of the research

      • Research Topics

        1. Synthesis and structural studies of the C1 homology domains of protein kinase C
        2. Structure-activity studies on tumor promoter teleocidins and development of new medicinal leads with protein kinase C isozyme selectivity
        3. Chemical studies on the aggregation mechanism of amyloid β (Aβ) peptides to develop new medicinal leads that inhibit Aβ aggregation
        4. Analysis and application of the enzyme that catalyzes the introduction of a nitrogen atom into the indole ring
        5. Development of new anti-cancer drugs based on the activation mechanism of protein kinase C by bryostatin
        6. Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
      • Overview of the research

        Aggregation of the 42-mer amyloid β protein (Aβ42) plays a critical role in the pathogenesis of Alzheimer's disease (AD). We have reported the importance of a turn at Glu-22 and Asp-23 of Aβ42 to induce its neurotoxicity through the formation of radicals. Based on the toxic turn structure, antibodies and compounds that inhibit the aggregation and neurotoxicity of Aβ are being developed. We focus mainly on the polyphenols in Foods as anti-aggregative compounds for Aβ.
        Protein kinase C (PKC) isozymes are widely recognized as targets for anti-cancer therapy. However, concerns exist about their therapeutic uses since most PKC activators are potent tumor-promoters. Bryostatin 1 (bryo-1) is a unique PKC activator with little tumor-promoting activities. Bryo-1 is undergoing clinical trials for the treatment of cancer. However, its limited availability from natural sources and difficulty in the synthesis hamper further studies on its mode of action and structural optimization. Recently, we have reported that the simple and less lipophilic analogue of tumor-promoting aplysiatoxin could be a promising lead for bryo-1-like anti-cancer drugs. In order to enhance its anti-proliferative activity against cancer cells, aplog-1 is being derivatized systematically. Moreover, the target sites of aplog-1 are being examined using FLAG-tagged-Aplog-1 and the beads technology developed by professor Handa.

      Research Interests

      • ペプチド化学
      • アルツハイマー
      • 発がん
      • 天然物化学
      • 生物有機化学
      • peptide chemistry
      • Alzheimer's disease
      • carcinogenesis
      • natural product chemistry
      • bio-organic chemistry

      Research Areas

      • Life sciences, Bioorganic chemistry, 天然物化学
      • Nanotechnology/Materials, Molecular biochemistry, ケミカルバイオロジー

      Papers

      • Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38
        Ayaka Chikugo; Yumi Irie; Chihiro Tsukano; Ayumi Uchino; Takahito Maki; Toshiaki Kume; Taiji Kawase; Kenji Hirose; Yusuke Kageyama; Ikuo Tooyama; Kazuhiro Irie
        ACS Chemical Neuroscience, in press, Sep. 2022, Peer-reviewed, Last author, Corresponding author
      • A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities
        Tomoki Sekido; Kosuke Yamamoto; Ryo C. Yanagita; Yasuhiro Kawamani; Yusuke Hanaki; Kazuhiro Irie
        Bioorganic & Medicinal Chemistry, Aug. 2022, Last author
      • Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models
        Ayumi Uchino; Yumi Irie; Chihiro Tsukano; Taiji Kawase; Kenji Hirose; Yusuke Kageyama; Ikuo Tooyama; Ryo C. Yanagita; Kazuhiro Irie
        ACS Chemical Neuroscience, Aug. 2022, Peer-reviewed, Last author, Corresponding author
      • Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 23
        Yumi Irie; Yuka Matsushima; Akiko Kita; Kunio Miki; Tatsuya Segawa; Masahiro Maeda; Ryo C. Yanagita; Kazuhiro Irie
        Biochemical and Biophysical Research Communications, Jul. 2022, Peer-reviewed, Last author, Corresponding author
      • Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(−)-carvone-based conformation-controlling unit
        Yoshiyuki Suzuki; Keiichi Moritoki; Mizuki Kajiwara; Ryo C Yanagita; Yasuhiro Kawanami; Yusuke Hanaki; Kazuhiro Irie
        Bioscience, Biotechnology, and Biochemistry, Jun. 2022, Peer-reviewed, Last author
      • AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity
        Jumpei Maki; Asami Oshimura; Chihiro Tsukano; Ryo C. Yanagita; Yutaka Saito; Yasubumi Sakakibara; Kazuhiro Irie
        Chemical Communications, Jun. 2022, Peer-reviewed, Last author, Corresponding author
      • Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study
        Ryo C. Yanagita; Mao Otani; Satoshi Hatanaka; Hiroto Nishi; Shota Miyake; Yusuke Hanaki; Masashi Sato; Yasuhiro Kawanami; Kazuhiro Irie
        Journal of Molecular Structure, Mar. 2022, Peer-reviewed, Last author
      • Structure optimization of the toxic conformation model of amyloid β42 by intramolecular disulfide bond formation
        Yuka Matsushima; Yumi Irie; Yusuke Kageyama; Jean-Pierre Bellier; Ikuo Tooyama; Takahito Maki; Toshiaki Kume; Ryo C Yanagita; Kazuhiro Irie
        ChemBioChem, Feb. 2022, Peer-reviewed, Last author, Corresponding author
      • Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis
        Mizuho Hanaki; Kazuma Murakami; Hiroki Gunji; Kazuhiro Irie
        Bioorganic & Medicinal Chemistry Letters, Feb. 2022, Peer-reviewed, Last author, Corresponding author
      • Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii
        Yohei Morishita; Kento Tsukada; Kazuma Murakami; Kazuhiro Irie; Teigo Asai
        Journal of Natural Products, Jan. 2022, Peer-reviewed
      • The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation
        Ayaka Washizaki; Megumi Murata; Yohei Seki; Masayuki Kikumori; Yinpui Tang; Weikeat Tan; Nadita P. Wardani; Kazuhiro Irie; Hirofumi Akari
        Viruses, Oct. 2021, Peer-reviewed
      • Asymmetric Total Synthesis of Shagenes A and B
        Chihiro Tsukano; Ryotaro Yagita; Takayoshi Heike; Tagwa A. Mohammed; Kazuya Nishibayashi; Kazuhiro Irie; Yoshiji Takemoto
        Angewandte Chemie International Edition, 23 Aug. 2021, Peer-reviewed
      • Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer’s Disease Therapeutics
        Kazuma Murakami; Shiori Horii; Mizuho Hanaki; Kazuhiro Irie
        ACS Chemical Neuroscience, Aug. 2021, Peer-reviewed, Last author, Corresponding author
      • Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain
        Yusuke Kageyama; Yumi Irie; Yuka Matsushima; Tatsuya Segawa; Jean-Pierre Bellier; Kumi Hidaka; Hiroshi Sugiyama; Daita Kaneda; Yoshio Hashizume; Hiroyasu Akatsu; Kunio Miki; Akiko Kita; Douglas G. Walker; Kazuhiro Irie; Ikuo Tooyama
        ACS Chemical Neuroscience, Aug. 2021, Peer-reviewed
      • Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β
        Naotaka Izuo; Takahiko Shimizu; Kazuma Murakami; Kazuhiro Irie
        YAKUGAKU ZASSHI, 01 Jun. 2021, Last author
      • Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris
        Tokio Hasegawa; Mayo Osaka; Yusaku Miyamae; Katsutoshi Nishino; Hiroko Isoda; Kiyokazu Kawada; Mohamed Neffati; Kazuhiro Irie; Masaya Nagao
        Chemistry, May 2021, Peer-reviewed
      • Studies Toward the Total Synthesis of Schinortriterpenoids: Diastereoselective Synthesis of the Left‐Hand Fragment
        Ryotaro Yagita; Kazuhiro Irie; Chihiro Tsukano
        European Journal of Organic Chemistry, May 2021, Peer-reviewed
      • アミロイドタンパク質を認識する核酸アプタマー
        村上一馬; 入江一浩
        化学と生物, May 2021, Peer-reviewed, Invited, Last author
      • Total synthesis and biological evaluation of oscillatoxin D, E, and F
        Yusuke Araki; Yusuke Hanaki; Masaki Kita; Koutaro Hayakawa; Kazuhiro Irie; Yoshihiko Nokura; Atsuo Nakazaki; Toshio Nishikawa
        Bioscience, Biotechnology, and Biochemistry, Apr. 2021, Peer-reviewed
      • Synthesis of Alkyl Bridged‐Tris‐α‐Amino Acids as C3‐Symmetric and Linear Linkers
        Ayumi Uchino; Chihiro Tsukano; Tsuneo Imamoto; Kazuhiro Irie
        European Journal of Organic Chemistry, 05 Mar. 2021, Peer-reviewed, Last author, Corresponding author
      • Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis
        Maho Yanagimichi; Katsutoshi Nishino; Akiho Sakamoto; Ryusei Kurodai; Kenji Kojima; Nozomu Eto; Hiroko Isoda; Riadh Ksouri; Kazuhiro Irie; Taiho Kambe; Seiji Masuda; Toru Akita; Kazuhiro Maejima; Masaya Nagao
        Biochemistry and Biophysics Reports, Mar. 2021, Peer-reviewed
      • Toxic Amyloid-β42 Conformer May Accelerate the Onset of Alzheimer’s Disease in the Preclinical Stage
        Akinori Futamura; Sotaro Hieda; Yukiko Mori; Kensaku Kasuga; Azusa Sugimoto; Hideyo Kasai; Takeshi Kuroda; Satoshi Yano; Mayumi Tsuji; Takeshi Ikeuchi; Kazuhiro Irie; Kenjiro Ono
        Journal of Alzheimer's Disease, 09 Feb. 2021, Peer-reviewed
      • Abietane diterpenoids from Salvia officinalis leaves as aryl hydrocarbon receptor ligands
        Katsutoshi Nishino; Kenta Someya; Riadh Ksouri; Toshio Ishikawa; Hiroko Isoda; Kazuhiro Irie; Masaya Nagao
        Phytochemistry Letters, Feb. 2021, Peer-reviewed
      • Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities
        Atsuko Gonda; Koji Takada; Ryo C Yanagita; Shingo Dan; Kazuhiro Irie
        Bioscience, Biotechnology, and Biochemistry, 07 Jan. 2021, Peer-reviewed, Last author, Corresponding author
      • Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction
        Takumi Kobayashi; Ryo C. Yanagita; Kazuhiro Irie
        Bioorganic & Medicinal Chemistry Letters, Dec. 2020, Peer-reviewed, Last author, Corresponding author
      • Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology
        Kazuma Murakami; Tomomi Yamaguchi; Naotaka Izuo; Toshiaki Kume; Hideyuki Hara; Kazuhiro Irie
        ACS Chemical Neuroscience, 07 Oct. 2020, Peer-reviewed, Last author, Corresponding author
      • Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease
        Yayoi Obata; Kazuma Murakami; Taiji Kawase; Kenji Hirose; Naotaka Izuo; Takahiko Shimizu; Kazuhiro Irie
        ACS Omega, 01 Sep. 2020, Peer-reviewed, Last author, Corresponding author
      • An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease
        Kazuma Murakami; Yayoi Obata; Asa Sekikawa; Haruka Ueda; Naotaka Izuo; Tatsuya Awano; Keiji Takabe; Takahiko Shimizu; Kazuhiro Irie
        Journal of Biological Chemistry, 10 Apr. 2020, Peer-reviewed, Last author, Corresponding author
      • Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
        Kento Tsukada; Shono Shinki; Akiho Kaneko; Kazuma Murakami; Kazuhiro Irie; Masatoshi Murai; Hideto Miyoshi; Shingo Dan; Kumi Kawaji; Hironori Hayashi; Eiichi N. Kodama; Aki Hori; Emil Salim; Takayuki Kuraishi; Naoya Hirata; Yasunari Kanda; Teigo Asai
        Nature Communications, Apr. 2020, Peer-reviewed
      • Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid
        Ryotaro Yagita; Kazuma Murakami; Hisafumi Ikeda; Kazuhiro Irie
        Tetrahedron Letters, Apr. 2020, Peer-reviewed, Last author, Corresponding author
      • Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.
        Tomohiro Imamura; Yuki T Yanagihara; Yasumasa Ohyagi; Norimichi Nakamura; Kyoko M Iinuma; Ryo Yamasaki; Hirohide Asai; Masahiro Maeda; Kazuma Murakami; Kazuhiro Irie; Jun-Ichi Kira
        Neurobiology of disease, Apr. 2020, Peer-reviewed
      • Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator
        Kazuma Murakami; Mayuko Yoshimura; Shota Nakagawa; Toshiaki Kume; Takayuki Kondo; Haruhisa Inoue; Kazuhiro Irie
        International Journal of Molecular Sciences, 11 Feb. 2020, Peer-reviewed, Last author, Corresponding author
      • New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β
        Kazuhiro Irie
        Bioscience, Biotechnology, and Biochemistry, 02 Jan. 2020, Peer-reviewed, Lead author, Corresponding author
      • Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology
        Kazuma Murakami; Haruka Kato; Mizuho Hanaki; Yoko Monobe; Ken-ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie
        RSC Advances, 2020, Peer-reviewed, Last author, Corresponding author
      • Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation
        Yuka Matsushima; Ryo C. Yanagita; Kazuhiro Irie
        Chemical Communications, 2020, Peer-reviewed, Last author, Corresponding author
      • Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1
        K. Nishino; H. Uesugi; A. Hirasawa; A. Ohtera; Y. Miyamae; M. Neffati; H. Isoda; T. Kambe; S. Masuda; K. Irie; M. Nagao
        Biochem. Biophys. Res. Commun., 2020, Peer-reviewed
      • An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.
        Naotaka Izuo; Kazuma Murakami; Yoshitaka Fujihara; Masahiro Maeda; Takashi Saito; Takaomi C Saido; Kazuhiro Irie; Takahiko Shimizu
        Biochemical and biophysical research communications, 30 Jul. 2019, Peer-reviewed
      • Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin
        Y. Ashida; R. C. Yanagita; Y. Kawanami; M. Okamura; S. Dan; K. Irie
        Heterocycles, 2019, Peer-reviewed, Last author
      • Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties
        K. Murakami; K. Irie
        Molecules, 2019, Peer-reviewed, Invited, Corresponding author
      • 分子模型
        K. Irie
        化学と生物, 2019, Invited, Lead author, Corresponding author
      • Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells
        C. Valentine; K. Ohnishi; K. Irie; A. Murakami
        J. Clin. Biochem. Nutr., 2019, Peer-reviewed
      • Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation
        Yumi Irie; Mizuho Hanaki; Kazuma Murakami; Tsuneo Imamoto; Takumi Furuta; Takeo Kawabata; Taiji Kawase; Kenji Hirose; Yoko Monobe; Ken-ichi Akagi; Ryo C. Yanagita; Kazuhiro Irie
        Chemical Communications, 2019, Peer-reviewed, Last author, Corresponding author
      • アミロイドβの毒性2量体および3量体モデルの合成と構造機能解析
        IRIE Kazuhiro
        有機合成化学協会誌, 2019, Peer-reviewed, Invited, Corresponding author
      • Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine
        Mizuho Hanaki; Kazuma Murakami; Sumie Katayama; Ken-ichi Akagi; Kazuhiro Irie
        Bioorganic and Medicinal Chemistry, 01 May 2018, Peer-reviewed, Last author, Corresponding author
      • Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques
        Y. Kageyama; A. Saito; O. Pletnikova; G. L. Rudow; Y. Irie; Y. An; K. Murakami; K. Irie; S. M. Resnick; D. R. Fowler; L. J. Martin; J. C. Troncoso
        Sci. Rep., 2018, Peer-reviewed
      • Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers
        Kazuma Murakami; Takuya Yoshioka; Shiori Horii; Mizuho Hanaki; Satohiro Midorikawa; Shinji Taniwaki; Hiroki Gunji; Ken-Ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie
        Chemical Communications, 2018, Peer-reviewed, Last author, Corresponding author
      • Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus.
        Chihiro Akiba; Madoka Nakajima; Masakazu Miyajima; Ikuko Ogino; Yumiko Motoi; Kaito Kawamura; Satoshi Adachi; Akihide Kondo; Hidenori Sugano; Takahiko Tokuda; Kazuhiro Irie; Hajime Arai
        Journal of Alzheimer's disease : JAD, 2018, Peer-reviewed
      • Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin
        K. Hayakawa; Y. Hanaki; H. Tokuda; R. C. Yanagita; Y. Nakagawa; M. Okamura; S. Dan; K. Irie
        Heterocycles, 2018, Peer-reviewed, Last author, Corresponding author
      • アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発
        泉尾直孝; 清水孝彦; 村上一馬; 入江一浩
        医薬品医療機器レギュラトリーサイエンス, 2018
      • Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines
        Yusuke Hanaki; Yuki Shikata; Masayuki Kikumori; Natsuki Hotta; Masaya Imoto; Kazuhiro Irie
        Biochemical and Biophysical Research Communications, 01 Jan. 2018, Peer-reviewed, Last author, Corresponding author
      • A Toxic Conformer of A beta 42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease
        Naotaka Izuo; Chihiro Kasahara; Kazuma Murakami; Toshiaki Kume; Masahiro Maeda; Kazuhiro Irie; Koutaro Yokote; Takahiko Shimizu
        SCIENTIFIC REPORTS, Sep. 2017, Peer-reviewed
      • INHIBITORY ACTIVITY OF HISPIDIN DERIVATIVES ISOLATED FROM INONOTUS OBLIQUUS ON AMYLOID beta AGGREGATION
        Yukine Aihara; Ayumi Kawaguchi; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hideyuki Shigemori
        HETEROCYCLES, Jul. 2017, Peer-reviewed
      • Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells
        Kyuichi Kawabata; Kenji Kitamura; Kazuhiro Irie; Shoma Naruse; Tomohiro Matsuura; Tomoyuki Uemae; Shu Taira; Hajime Ohigashi; Shigeru Murakami; Masakazu Takahashi; Yoko Kaido; Bunsei Kawakami
        JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Jun. 2017, Peer-reviewed
      • Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities
        Yusuke Hanaki; Masayuki Kikumori; Harukuni Tokuda; Mutsumi Okamura; Shingo Dan; Naoko Adachi; Naoaki Saito; Ryo C. Yanagita; Kazuhiro Irie
        MOLECULES, Apr. 2017, Peer-reviewed, Last author, Corresponding author
      • Synthetic Models of Quasi-Stable Amyloid beta 40 Oligomers with Significant Neurotoxicity
        Yumi Irie; Kazuma Murakami; Mizhuo Hanaki; Yusuke Hanaki; Takashi Suzuki; Yoko Monobe; Tomoyo Takai; Ken-ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie
        ACS CHEMICAL NEUROSCIENCE, Apr. 2017, Peer-reviewed, Last author, Corresponding author
      • Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases
        Asma Ben Hmidene; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hiroko Isoda; Hideyuki Shigemori
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2017, Peer-reviewed
      • 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析
        K. Murakami; K. Irie
        日本認知症学会誌, 2017, Invited, Last author, Corresponding author
      • Synthesized A beta 42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture
        Yuki Oku; Kazuma Murakami; Kazuhiro Irie; Jun Hoseki; Yasuyoshi Sakai
        CELL STRUCTURE AND FUNCTION, 2017, Peer-reviewed
      • STRUCTURE-ACTIVITY RELATIONSHIP OF PHENYLETHANOID GLYCOSIDES ON THE INHIBITION OF AMYLOID beta AGGREGATION
        Eri Kidachi; Manami Kurisu; Yusaku Miyamae; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hideyuki Shigemori
        HETEROCYCLES, Nov. 2016, Peer-reviewed
      • Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid beta 42 Aggregation
        Takuya Yoshioka; Kazuma Murakami; Kyohei Ido; Mizuho Hanaki; Kanoko Yamaguchi; Satohiro Midorikawa; Shinji Taniwaki; Hiroki Gunji; Kazuhiro Irie
        JOURNAL OF NATURAL PRODUCTS, Oct. 2016, Peer-reviewed, Last author, Corresponding author
      • Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain
        Yoshiki Ashida; Ryo C. Yanagita; Chise Takahashi; Yasuhiro Kawanami; Kazuhiro Irie
        BIOORGANIC & MEDICINAL CHEMISTRY, Sep. 2016, Peer-reviewed, Last author
      • Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1
        Yoko Igarashi; Kohta Ohnishi; Kazuhiro Irie; Akira Murakami
        PLOS ONE, Aug. 2016, Peer-reviewed
      • Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.
        Kazuma Murakami; Maki Tokuda; Takashi Suzuki; Yumi Irie; Mizuho Hanaki; Naotaka Izuo; Yoko Monobe; Ken-Ichi Akagi; Ryotaro Ishii; Harutsugu Tatebe; Takahiko Tokuda; Masahiro Maeda; Toshiaki Kume; Takahiko Shimizu; Kazuhiro Irie
        Scientific reports, 04 Jul. 2016, Peer-reviewed, Last author, Corresponding author
      • Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead
        Masayuki Kikumori; Ryo C. Yanagita; Harukuni Tokuda; Kiyotake Suenaga; Hiroshi Nagai; Kazuhiro Irie
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Feb. 2016, Peer-reviewed, Last author, Corresponding author
      • アルツハイマー病の正確な早期診断の実現に向けて
        IRIE Kazuhiro
        化学, 2016, Invited, Corresponding author
      • Structural insights into mechanisms for inhibiting amyloid beta 42 aggregation by non-catechol-type flavonoids
        Mizuho Hanaki; Kazuma Murakami; Ken-ichi Akagi; Kazuhiro Irie
        BIOORGANIC & MEDICINAL CHEMISTRY, Jan. 2016, Peer-reviewed, Last author, Corresponding author
      • Identification of a New Type of Covalent PPAR gamma Agonist using a Ligand-Linking Strategy
        Anna Ohtera; Yusaku Miyamae; Kotaro Yoshida; Kazuhiro Maejima; Toru Akita; Akira Kakizuka; Kazuhiro Irie; Seiji Masuda; Taiho Kambe; Masaya Nagao
        ACS CHEMICAL BIOLOGY, Dec. 2015, Peer-reviewed
      • Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting
        Ayako Hashimoto; Katsuma Ohkura; Masakazu Takahashi; Kumiko Kizu; Hiroshi Narita; Shuichi Enomoto; Yusaku Miyamae; Seiji Masuda; Masaya Nagao; Kazuhiro Irie; Hajime Ohigashi; Glen K. Andrews; Taiho Kambe
        BIOCHEMICAL JOURNAL, Dec. 2015, Peer-reviewed
      • Synthesis and characterization of the amyloid beta 40 dimer model with a linker at position 30 adjacent to the intermolecular beta-sheet region
        Kazuma Murakami; Takashi Suzuki; Mizuho Hanaki; Yoko Monobe; Ken-ichi Akagi; Kazuhiro Irie
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2015, Peer-reviewed, Last author, Corresponding author
      • Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities
        Yusuke Hanaki; Ryo C. Yanagita; Takahiro Sugahara; Misako Aida; Harukuni Tokuda; Nobutaka Suzuki; Kazuhiro Irie
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jun. 2015, Peer-reviewed, Last author, Corresponding author
      • アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割
        泉尾直孝; 村上一馬; 久米利明; 前田雅弘; 入江一浩; 清水孝彦
        基礎老化研究, 2015, Invited
      • Identification and characterization of PKCP gamma, a kinase associated with SCA14, as an amyloidogenic protein
        Hideyuki Takahashi; Naoko Adachi; Toshihiko Shirafuji; Sally Danno; Takehiko Ueyama; Michele Vendruscolo; Anton N. Shuvaev; Takuya Sugimoto; Takahiro Seki; Daizo Hamada; Kazuhiro Irie; Hirokazu Hirai; Norio Sakai; Naoaki Saito
        HUMAN MOLECULAR GENETICS, Jan. 2015, Peer-reviewed
      • Two New Lyngbyatoxin Derivatives from the Cyanobacterium, Moorea producens
        Weina Jiang; Satoshi Tan; Yusuke Hanaki; Kazuhiro Irie; Hajime Uchida; Ryuichi Watanabe; Toshiyuki Suzuki; Bryan Sakamoto; Michiya Kamio; Hiroshi Nagai
        MARINE DRUGS, Dec. 2014, Peer-reviewed
      • Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug
        Masayuki Kikumori; Ryo C. Yanagita; Kazuhiro Irie
        TETRAHEDRON, Dec. 2014, Peer-reviewed, Last author, Corresponding author
      • Potential Role of Vitamin C in the Prevention of Alzheimer's Disease
        Kazuma Murakami; Kazuhiro Irie; Takahiko Shimizu
        Diet and Nutrition in Dementia and Cognitive Decline, 18 Nov. 2014, Peer-reviewed
      • A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens
        Weina Jiang; Wei Zhou; Hajime Uchida; Masayuki Kikumori; Kazuhiro Irie; Ryuichi Watanabe; Toshiyuki Suzuki; Bryan Sakamoto; Michiya Kamio; Hiroshi Nagai
        MARINE DRUGS, May 2014, Peer-reviewed
      • Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin
        Kazuhiro Irie; Ryo C. Yanagita
        CHEMICAL RECORD, Apr. 2014, Peer-reviewed, Lead author, Corresponding author
      • Modulation of protein quality control systems as novel mechanisms underlying functionality of food phytochemicals
        Kohta Ohnishi; Kazuhiro Irie; Akira Murakami
        Functional Foods in Health and Disease, Oct. 2013, Peer-reviewed
      • Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist
        Anna Ohtera; Yusaku Miyamae; Naomi Nakai; Atsushi Kawachi; Kiyokazu Kawada; Junkyu Han; Hiroko Isoda; Mohamed Neffati; Toru Akita; Kazuhiro Maejima; Seiji Masuda; Taiho Kambe; Naoki Mori; Kazuhiro Irie; Masaya Nagao
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2013, Peer-reviewed
      • Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity
        Yusuke Hanaki; Masayuki Kikumori; Sayo Ueno; Harukuni Tokuda; Nobutaka Suzuki; Kazuhiro Irie
        Tetrahedron, 09 Sep. 2013, Peer-reviewed, Last author, Corresponding author
      • Proteostress-associated mechanisms underlying physiological activities of zerumbone, a chemopreventive agent
        Kohta OHNISHI; Kazuhiro IRIE; Akira MURAKAMI
        Bioscience & industry, Sep. 2013, Invited
      • Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.
        Naotaka Izuo; Kazuma Murakami; Mizuho Sato; Mami Iwasaki; Yasuhiko Izumi; Takahiko Shimizu; Akinori Akaike; Kazuhiro Irie; Toshiaki Kume
        Biochemical and biophysical research communications, 16 Aug. 2013, Peer-reviewed
      • Site-specific Inhibitory Mechanism for Amyloid beta 42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues
        Mizuho Sato; Kazuma Murakami; Mayumi Uno; Yu Nakagawa; Sumie Katayama; Ken-ichi Akagi; Yuichi Masuda; Kiyonori Takegoshi; Kazuhiro Irie
        JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2013, Peer-reviewed, Last author, Corresponding author
      • Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities
        Ryo C. Yanagita; Hiroaki Kamachi; Masayuki Kikumori; Harukuni Tokuda; Nobutaka Suzuki; Kiyotake Suenaga; Hiroshi Nagai; Kazuhiro Irie
        Bioorganic and Medicinal Chemistry Letters, 01 Aug. 2013, Peer-reviewed, Last author, Corresponding author
      • Inhibition of Amyloid beta Aggregation by Acteoside, a Phenylethanoid Glycoside
        Manami Kurisu; Yusaku Miyamae; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jun. 2013, Peer-reviewed
      • Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity
        Hiroaki Kamachi; Keisuke Tanaka; Ryo C. Yanagita; Akira Murakami; Kazuma Murakami; Harukuni Tokuda; Nobutaka Suzuki; Yu Nakagawa; Kazuhiro Irie
        BIOORGANIC & MEDICINAL CHEMISTRY, May 2013, Peer-reviewed, Last author, Corresponding author
      • Structure-Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid beta Aggregation
        Mizuho Sato; Kazuma Murakami; Mayumi Uno; Haruko Ikubo; Yu Nakagawa; Sumie Katayama; Ken-ichi Akagi; Kazuhiro Irie
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2013, Peer-reviewed, Corresponding author
      • Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular A beta and Differential Drug Responsiveness
        Takayuki Kondo; Masashi Asai; Kayoko Tsukita; Yumiko Kutoku; Yutaka Ohsawa; Yoshihide Sunada; Keiko Imamura; Naohiro Egawa; Naoki Yahata; Keisuke Okita; Kazutoshi Takahashi; Isao Asaka; Takashi Aoi; Akira Watanabe; Kaori Watanabe; Chie Kadoya; Rie Nakano; Dai Watanabe; Kei Maruyama; Osamu Hori; Satoshi Hibino; Tominari Choshi; Tatsutoshi Nakahata; Hiroyuki Hioki; Takeshi Kaneko; Motoko Naitoh; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Ryuji Hata; Shu-ichi Ueno; Tsuneyoshi Seki; Kazuhiro Kobayashi; Tatsushi Toda; Kazuma Murakami; Kazuhiro Irie; William L. Klein; Hiroshi Mori; Takashi Asada; Ryosuke Takahashi; Nobuhisa Iwata; Shinya Yamanaka; Haruhisa Inoue
        CELL STEM CELL, Apr. 2013, Peer-reviewed
      • Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense
        Kohta Ohnishi; Shinya Ohkura; Erina Nakahata; Akari Ishisaka; Yoshichika Kawai; Junji Terao; Taiki Mori; Takeshi Ishii; Tsutomu Nakayama; Noriyuki Kioka; Shinya Matsumoto; Yasutaka Ikeda; Minoru Akiyama; Kazuhiro Irie; Akira Murakami
        PLOS ONE, Mar. 2013, Peer-reviewed
      • Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy
        Kohta Ohnishi; Erina Nakahata; Kazuhiro Irie; Akira Murakami
        Biochemical and Biophysical Research Communications, 11 Jan. 2013, Peer-reviewed
      • Intracellular Accumulation of Toxic Turn Amyloid-beta is Associated with Endoplasmic Reticulum Stress in Alzheimer's Disease
        Naoko Soejima; Yasumasa Ohyagi; Norimichi Nakamura; Eri Himeno; Kyoko M. Iinuma; Nobutaka Sakae; Ryo Yamasaki; Takeshi Tabira; Kazuma Murakami; Kazuhiro Irie; Noriaki Kinoshita; Frank M. LaFerla; Yutaka Kiyohara; Toru Iwaki; Jun-ichi Kira
        CURRENT ALZHEIMER RESEARCH, Jan. 2013, Peer-reviewed
      • Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability
        Yuki Ikeda; Ryoichi Yamaji; Kazuhiro Irie; Noriyuki Kioka; Akira Murakami
        ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Dec. 2012, Peer-reviewed
      • SYNTHESIS OF ANTINEOPLASTIC ANALOGS OF APLYSIATOXIN WITH VARIOUS SIDE CHAIN STRUCTURES
        Yuki Shu; Ryo C. Yanagita; Harukuni Tokuda; Nobutaka Suzuki; Kazuhiro Irie
        HETEROCYCLES, Dec. 2012, Peer-reviewed, Last author, Corresponding author
      • Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-A beta APP mutation
        L. Kulic; J. McAfoose; T. Welt; C. Tackenberg; C. Spaeni; F. Wirth; V. Finder; U. Konietzko; M. Giese; A. Eckert; K. Noriaki; T. Shimizu; K. Murakami; K. Irie; S. Rasool; C. Glabe; C. Hock; R. M. Nitsch
        TRANSLATIONAL PSYCHIATRY, Nov. 2012, Peer-reviewed
      • Solid-state NMR analysis of the beta-strand orientation of the protofibrils of amyloid beta-protein
        Takashi Doi; Yuichi Masuda; Kazuhiro Irie; Ken-ichi Akagi; Youko Monobe; Takayoshi Imazawa; K. Takegoshi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2012, Peer-reviewed
      • Caffeoylquinic acids inhibit amyloid β fibril formation and cellular toxicity.
        Miyamae, Y; Kurisu, M; Murakami, K; Han, J; Isoda, H; Irie, K; Shigemori, H
        Bioorg. Med. Chem. 19 (1), 5844-5849 (2012)., Oct. 2012, Peer-reviewed
      • Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid beta-protein
        Yusaku Miyamae; Manami Kurisu; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori
        BIOORGANIC & MEDICINAL CHEMISTRY, Oct. 2012, Peer-reviewed
      • Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of A beta 42
        Naotaka Izuo; Toshiaki Kume; Mizuho Sato; Kazuma Murakami; Kazuhiro Irie; Yasuhiko Izumi; Akinori Akaike
        ACS CHEMICAL NEUROSCIENCE, Sep. 2012, Peer-reviewed, Corresponding author
      • Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
        Yasuhiko Izumi; Atsuko Matsumura; Seiko Wakita; Ken-ichi Akagi; Hiroyuki Fukuda; Toshiaki Kume; Kazuhiro Irie; Yuki Takada-Takatori; Hachiro Sugimoto; Tadashi Hashimoto; Akinori Akaike
        FREE RADICAL BIOLOGY AND MEDICINE, Aug. 2012, Peer-reviewed
      • Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor
        Fumitada Tsuji; Ayako Ishihara; Aya Nakagawa; Masahiro Okada; Shigeyuki Kitamura; Kyoko Kanamaru; Yuichi Masuda; Kazuma Murakami; Kazuhiro Irie; Youji Sakagami
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2012, Peer-reviewed
      • Auraptene Attenuates Gastritis via Reduction of Helicobacter pylori Colonization and Pro-Inflammatory Mediator Production in C57BL/6 Mice
        Hirotaka Sekiguchi; Fumiyo Takabayashi; Kazuhiro Irie; Akira Murakami
        JOURNAL OF MEDICINAL FOOD, Jul. 2012, Peer-reviewed
      • Structure-Activity Studies on the Spiroketal Moiety of a Simplified Analogue of Debromoaplysiatoxin with Antiproliferative Activity
        Masayuki Kikumori; Ryo C. Yanagita; Harukuni Tokuda; Nobutaka Suzuki; Hiroshi Nagai; Kiyotake Suenaga; Kazuhiro Irie
        JOURNAL OF MEDICINAL CHEMISTRY, Jun. 2012, Peer-reviewed, Last author, Corresponding author
      • Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model
        Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jun. 2012, Peer-reviewed
      • Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C delta
        Kazuhiro Irie; Ryo C. Yanagita; Yu Nakagawa
        MEDICINAL RESEARCH REVIEWS, May 2012, Peer-reviewed, Lead author, Corresponding author
      • Identification and Biological Activities of Bryostatins from Japanese Bryozoan
        Sayo Ueno; Ryo C. Yanagita; Kazuma Murakami; Akira Murakami; Harukuni Tokuda; Nobutaka Suzuki; Takeshi Fujiwara; Kazuhiro Irie
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2012, Peer-reviewed, Last author, Corresponding author
      • Molecular mechanisms underlying chemopreventive activities of zerumbone, a sesquiterpene derived from shampoo ginger
        Kohta OHNISHI; Kazuhiro IRIE; Akira MURAKAMI
        Vitamins (Japan), Mar. 2012, Invited
      • Aβの毒性ターン構造を認識する抗体
        村上一馬; 入江一浩
        神経内科, 2012, Last author, Corresponding author
      • アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異
        村上一馬; 佐藤瑞穂; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩
        Dementia Japan, 2012, Last author, Corresponding author
      • Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1
        Kazuhiro Irie; Masayuki Kikumori; Hiroaki Kamachi; Keisuke Tanaka; Akira Murakami; Ryo C. Yanagita; Harukuni Tokuda; Nobutaka Suzuki; Hiroshi Nagai; Kiyotake Suenaga; Yu Nakagawa
        PURE AND APPLIED CHEMISTRY, 2012, Peer-reviewed, Lead author, Corresponding author
      • Geranyl modification on the tryptophan residue of ComX(RO-E-2) pheromone by a cell-free system
        Fumitada Tsuji; Ayako Ishihara; Keiko Kurata; Aya Nakagawa; Masahiro Okada; Shigeyuki Kitamura; Kyoko Kanamaru; Yuichi Masuda; Kazuma Murakami; Kazuhiro Irie; Youji Sakagami
        FEBS LETTERS, Jan. 2012, Peer-reviewed
      • SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid beta Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease
        Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Shoichi Tahara; Takao Kaneko; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Kevin J. Barnham; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2011, Peer-reviewed
      • アルツハイマー病の分子治療戦略 新しい視点を求めて アミロイドβの毒性ターン構造を認識する抗体の開発
        入江 一浩; 村上 一馬; 増田 裕一; 村田 央; 野田 義博; 初田 裕幸; 村山 繁雄; 清水 孝彦; 堀越 優子; 木下 憲明; 白澤 卓二
        臨床神経学, Nov. 2011, Lead author, Corresponding author
      • 1,2-Di-O-alpha-linolenoyl-3-O-beta-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa
        Masakazu Takahashi; Yuta Sugiyama; Kyuichi Kawabata; Yu Takahashi; Kazuhiro Irie; Akira Murakami; Yoshito Kubo; Kyoichi Kobayashi; Hajime Ohigashi
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2011, Peer-reviewed
      • Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid beta-protein fibrils
        Yuichi Masuda; Masashi Fukuchi; Tatsuya Yatagawa; Masato Tada; Kazuyuki Takeda; Kazuhiro Irie; Ken-ichi Akagi; Youko Monobe; Takayoshi Imazawa; K. Takegoshi
        BIOORGANIC & MEDICINAL CHEMISTRY, Oct. 2011, Peer-reviewed
      • Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP
        Tatsuro Kawamura; Kohei Matsubara; Hitomi Otaka; Etsu Tashiro; Kazutoshi Shindo; Ryo C. Yanagita; Kazuhiro Irie; Masaya Imoto
        BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2011, Peer-reviewed
      • Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin
        Yu Nakagawa; Masayuki Kikumori; Ryo C. Yanagita; Akira Murakami; Harukuni Tokuda; Hiroshi Nagai; Kazuhiro Irie
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jun. 2011, Peer-reviewed, Last author, Corresponding author
      • Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice
        Kazuma Murakami; Shin-ichi Yokoyama; Nakaba Murata; Yusuke Ozawa; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, Peer-reviewed
      • Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23
        Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Nakaba Murata; Yoshihiro Noda; Hiroyuki Hatsuta; Shigeo Murayama; Takahiko Shimizu; Yuko Horikoshi; Noriaki Kinoshita; Takuji Shirasawa
        Clinical Neurology, 2011, Peer-reviewed, Lead author, Corresponding author
      • Vitamin C Restores Behavioral Deficits and Amyloid-beta Oligomerization without Affecting Plaque Formation in a Mouse Model of Alzheimer's Disease
        Kazuma Murakami; Nakaba Murata; Yusuke Ozawa; Noriaki Kinoshita; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        JOURNAL OF ALZHEIMERS DISEASE, 2011, Peer-reviewed
      • Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease
        K. Murakami; T. Shimizu; K. Irie
        J. Amino Acids, ID 654207, 2011, Peer-reviewed, Last author
      • E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.
        Takayuki Suzuki; Kazuma Murakami; Naotaka Izuo; Toshiaki Kume; Akinori Akaike; Tetsu Nagata; Tomoyuki Nishizaki; Takami Tomiyama; Hiroshi Takuma; Hiroshi Mori; Kazuhiro Irie
        International journal of Alzheimer's disease, 19 Dec. 2010, Peer-reviewed, Last author, Corresponding author
      • Silymarin Attenuated the Amyloid beta Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model
        Nakaba Murata; Kazuma Murakami; Yusuke Ozawa; Noriaki Kinoshita; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2010, Peer-reviewed
      • Monoclonal Antibody Against the Turn of the 42-Residue Amyloid beta-Protein at Positions 22 and 23
        Kazuma Murakami; Yuko Horikoshi-Sakuraba; Nakaba Murata; Yoshihiro Noda; Yuichi Masuda; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie
        ACS CHEMICAL NEUROSCIENCE, Nov. 2010, Peer-reviewed, Last author, Corresponding author
      • Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity
        Ryo C. Yanagita; Hiroaki Kamachi; Keisuke Tanaka; Akira Murakami; Yu Nakagawa; Harukuni Tokuda; Hiroshi Nagai; Kazuhiro Irie
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Oct. 2010, Peer-reviewed, Last author, Corresponding author
      • Downregulation of Programmed Cell Death 4 by Inflammatory Conditions Contributes to the Generation of the Tumor Promoting Microenvironment
        Michiko Yasuda; Tobias Schmid; Daniela Ruebsamen; Nancy H. Colburn; Kazuhiro Irie; Akira Murakami
        MOLECULAR CARCINOGENESIS, Sep. 2010, Peer-reviewed
      • The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: The emerging role in the pathogenesis of Alzheimer's disease
        Kazuma Murakami; Yuichi Masuda; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie
        GERIATRICS & GERONTOLOGY INTERNATIONAL, Jul. 2010, Peer-reviewed, Last author
      • Suppression of CD74 Expression and Helicobacter pylori Adhesion by Auraptene Targeting Serum Starvation-Activated ERK1/2 in NCI-N87 Gastric Carcinoma Cells
        Hirotaka Sekiguchi; Kazuhiro Irie; Akira Murakami
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2010, Peer-reviewed
      • Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages
        M. Yasuda; K. Irie; A. Murakami
        Biosci. Biotechnol. Biochem., 2010, Peer-reviewed
      • ポリフェノールによるアルツハイマー病予防の可能性
        増田 裕一; 入江 一浩
        FFIジャーナル, 2010, Peer-reviewed, Last author, Corresponding author
      • Enzymatic Production of (-)-Indolactam V by LtxB, a Cytochrome P450 Monooxygenase
        Minh U. Huynh; Matthew C. Elston; Nick M. Hernandez; David B. Ball; Shin-ichiro Kajiyama; Kazuhiro Irie; William H. Gerwick; Daniel J. Edwards
        JOURNAL OF NATURAL PRODUCTS, Jan. 2010, Peer-reviewed
      • Stomatal Density is Controlled by a Mesophyll-Derived Signaling Molecule
        Tatsuhiko Kondo; Ryoko Kajita; Aya Miyazaki; Mayumi Hokoyama; Touko Nakamura-Miura; Satoko Mizuno; Yuichi Masuda; Kazuhiro Irie; Yuki Tanaka; Shinobu Takada; Tatsuo Kakimoto; Youji Sakagami
        PLANT AND CELL PHYSIOLOGY, Jan. 2010, Peer-reviewed
      • A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible Protein Kinase C Activator with Bryostatin-like Activity
        Yu Nakagawa; Ryo C. Yanagita; Naoko Hamada; Akira Murakami; Hideyuki Takahashi; Naoaki Saito; Hiroshi Nagai; Kazuhiro Irie
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2009, Peer-reviewed, Last author, Corresponding author
      • In vitro covalent binding proteins of zerumbone, a chemopreventive food factor
        K. Ohnishi; K. Irie; A. Murakami
        Biosci. Biotechnol. Biochem., 2009, Peer-reviewed
      • Identification of Physiological and Toxic Conformations in A beta 42 Aggregates
        Yuichi Masuda; Satoko Uemura; Ryutaro Ohashi; Azusa Nakanishi; K. Takegoshi; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        CHEMBIOCHEM, Jan. 2009, Peer-reviewed, Last author, Corresponding author
      • Verification of the intermolecular parallel beta-sheet in E22K-A beta 42 aggregates by solid-state NMR using rotational resonance: Implications for the supramolecular arrangement of the toxic conformer of A beta 42
        Yuichi Masuda; Azusa Nakanishi; Ryutaro Ohashi; Kiyonori Takegoshi; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 2008, Peer-reviewed, Last author, Corresponding author
      • Verification of the C-terminal intramolecular beta-sheet in A beta 42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals
        Yuichi Masuda; Satoko Uemura; Azusa Nakanishi; Ryutaro Ohashi; K. Takegoshi; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jun. 2008, Peer-reviewed, Last author, Corresponding author
      • Isomerization and/or racemization at Asp23 of A beta 42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro
        Kazuma Murakami; Mayumi Uno; Yuichi Masuda; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2008, Peer-reviewed, Last author, Corresponding author
      • 化学の窓 βアミロイドの毒性コンホメーション
        IRIE Kazuhiro; MASUDA Yuichi
        KAGAKU TO SEIBUTSU, 2008, Last author, Corresponding author
      • アミロイドβ(Aβ42)の毒性コンホメーションの提唱
        村上 一馬; 清水 孝彦; 白澤 卓二; 入江 一浩
        基礎老化研究, 2008, Peer-reviewed, Last author
      • Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction
        Takuya Sugimoto; Koji Itagaki; Kazuhiro Irie
        BIOORGANIC & MEDICINAL CHEMISTRY, Jan. 2008, Peer-reviewed, Last author, Corresponding author
      • Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes
        Ryo C. Yanagita; Yu Nakagawa; Nobuhiro Yamanaka; Kaori Kashiwagi; Naoaki Saito; Kazuhiro Irie
        JOURNAL OF MEDICINAL CHEMISTRY, Jan. 2008, Peer-reviewed, Last author, Corresponding author
      • Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: Implications for the stronger neurotoxicity of A beta 42 than A beta 40
        Kazuma Murakami; Hideyuki Hara; Yuichi Masuda; Hajime Ohigashi; Kazuhiro Irie
        CHEMBIOCHEM, Dec. 2007, Peer-reviewed, Last author, Corresponding author
      • Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes
        Ryo C. Yanagita; Keiji Torii; Yu Nakagawa; Kazuhiro Irie
        HETEROCYCLES, Dec. 2007, Peer-reviewed, Last author, Corresponding author
      • The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease
        K. Irie; K. Murakami; Y. Masuda; A. Morimoto; H. Ohigashi; H. Hara; R. Ohashi; K. Takegoshi; H. Fukuda; M. Naga; T. Shimizu; T. Shirasawa
        MINI-REVIEWS IN MEDICINAL CHEMISTRY, Oct. 2007, Peer-reviewed, Lead author, Corresponding author
      • Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta
        Y Nakagawa; K Irie; RC Yanagita; H Ohigashi; K Tsuda; K Kashiwagi; N Saito
        JOURNAL OF MEDICINAL CHEMISTRY, May 2006, Peer-reviewed, Corresponding author
      • CH/π相互作用を利用した薬剤開発
        入江 一浩
        ファルマシア, 2006, Peer-reviewed, Lead author, Corresponding author
      • Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR
        Y Masuda; K Irie; K Murakami; H Ohigashi; R Ohashi; K Takegoshi; T Shimizu; T Shirasawa
        BIOORGANIC & MEDICINAL CHEMISTRY, Dec. 2005, Peer-reviewed, Corresponding author
      • Formation and stabilization model of the 42-mer A beta radical: Implications for the long-lasting oxidative stress in Alzheimer's disease
        K Murakami; K Irie; H Ohigashi; H Hara; M Nagao; T Shimizu; T Shirasawa
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2005, Peer-reviewed, Corresponding author
      • Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: Implications for the pathogenesis of Alzheimer's disease
        K Irie; K Murakami; Y Masuda; A Morimoto; H Ohigashi; R Ohashi; K Takegoshi; M Nagao; T Shimizu; T Shirasawa
        JOURNAL OF BIOSCIENCE AND BIOENGINEERING, May 2005, Peer-reviewed, Lead author, Corresponding author
      • Indolactam-V is involved in the CH/pi interaction with pro-11 of the PKC delta C1B domain: Application for the structural optimization of the PKC delta ligand
        Y Nakagawa; K Irie; RC Yanagita; H Ohigashi; K Tsuda
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2005, Peer-reviewed, Corresponding author
      • Toward the development of new medicinal leads with selectivity for protein kinase C isozymes
        K Irie; Y Nakagawa; H Ohigashi
        CHEMICAL RECORD, 2005, Peer-reviewed, Lead author, Corresponding author
      • In vivo neuroprotective activity of epopeptide AB against ischemic damage
        M Nagao; TC Wen; M Okamoto; K Irie; T Takaku; M Sakanaka
        CYTOTECHNOLOGY, Jan. 2005, Peer-reviewed
      • Analysis of the secondary structure of beta-amyloid (A beta 42) fibrils by systematic proline replacement
        A Morimoto; K Irie; K Murakami; Y Masuda; H Ohigashi; M Nagao; H Fukuda; T Shimizu; T Shirasawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2004, Peer-reviewed, Corresponding author
      • Tumor promoter binding of the protein kinase CC1 homology domain peptides of RasGRPs, chimaerins, and Unc13s
        K Irie; A Masuda; M Shindo; Y Nakagawa; H Ohigashi
        BIOORGANIC & MEDICINAL CHEMISTRY, Sep. 2004, Peer-reviewed, Lead author, Corresponding author
      • Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V
        Y Nakagawa; K Irie; Y Komiya; H Ohigashi; K Tsuda
        TETRAHEDRON, Aug. 2004, Peer-reviewed, Corresponding author
      • ペプチド合成によるホルボールエステル受容体の機能解析
        入江一浩; 大東 肇
        化学と生物, 42/1, 54-62, 2004, Peer-reviewed, Lead author, Corresponding author
      • Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry
        M Shindo; K Irie; H Fukuda; H Ohigashi
        BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2003, Peer-reviewed, Corresponding author
      • Neurotoxicity and physicochemical properties of A beta mutant peptides from cerebral amyloid angiopathy - Implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease
        K Murakami; K Irie; A Morimoto; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2003, Peer-reviewed, Corresponding author
      • Synthesis and binding selectivity of 7-and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes
        Y Nakagawa; K Irie; N Yamanaka; H Ohigashi; K Tsuda
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Sep. 2003, Peer-reviewed, Corresponding author
      • Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes - DGK gamma and DGK gamma are new targets of tumor-promoting phorbol esters
        M Shindo; K Irie; A Masuda; H Ohigashi; Y Shirai; K Miyasaka; N Saito
        JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, Peer-reviewed, Corresponding author
      • Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23
        A Morimoto; K Irie; K Murakami; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2002, Peer-reviewed, Corresponding author
      • Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes
        A Masuda; K Irie; Y Nakagawa; H Ohigashi
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2002, Peer-reviewed, Corresponding author
      • Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23
        K Murakami; K Irie; A Morimoto; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2002, Peer-reviewed, Corresponding author
      • Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s
        Y Nakagawa; K Irie; A Masuda; H Ohigashi
        TETRAHEDRON, Mar. 2002, Peer-reviewed, Corresponding author
      • Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity
        K Irie; A Nakahara; Y Nakagawa; H Ohigashi; M Shindo; H Fukuda; H Konishi; U Kikkawa; K Kashiwagi; N Saito
        PHARMACOLOGY & THERAPEUTICS, Feb. 2002, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and functional analysis of the cysteine-rich domains of protein kinase C (PKC) for development of new medicinal leads with PKC isozyme and C1 domain selectivity
        Kazuhiro Irie; Hajime Ohigashi
        Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2002, Peer-reviewed, Lead author, Corresponding author
      • Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters
        M Shindo; K Irie; H Ohigashi; M Kuriyama; N Saito
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2001, Peer-reviewed, Corresponding author
      • Toward the identification of selective modulators of protein kinase C (PKC) isozymes: Establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding
        M Shindo; K Irie; A Nakahara; H Ohigashi; H Konishi; U Kikkawa; H Fukuda; PA Wender
        BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2001, Peer-reviewed, Corresponding author
      • The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities
        Y Nakagawa; K Irie; Y Nakamura; H Ohigashi
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 2001, Peer-reviewed, Corresponding author
      • The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding
        M Tanaka; K Irie; Y Nakagawa; Y Nakamura; H Ohigashi; PA Wender
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 2001, Peer-reviewed, Corresponding author
      • Synthesis and tumor-promoting activities of 12-epi-phorbol-12, 13-dibutyrate
        K Irie; A Nakahara; Y Ikawa; M Tanaka; Y Nakagawa; Y Nakamura; H Ohigashi; PA Wender
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2000, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V
        Y Nakagawa; K Irie; H Ohigashi; H Hayashi; PA Wender
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Sep. 2000, Peer-reviewed, Corresponding author
      • 発がんプロモーターのnPKC C1Bドメインへの選択的結合
        中川 優; 入江 一浩
        バイオサイエンスとインダストリー, 58/8, 570-571, 2000, Peer-reviewed, Last author, Corresponding author
      • A new class of simplified phorbol ester analogues: Synthesis and binding to PKC and eta PKC-C1B (eta PKC-CPD2)
        PA Wender; TA Kirschberg; PD Williams; HMM Bastiaans; K Irie
        ORGANIC LETTERS, Oct. 1999, Peer-reviewed
      • Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-indolactam-V and (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum
        K Irie; S Tomimatsu; Y Nakagawa; H Ohigashi; H Hayashi
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 1999, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D
        K Irie; A Nakahara; H Ohigashi; H Fukuda; PA Wender; H Konishi; U Kikkawa
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Sep. 1999, Peer-reviewed, Lead author, Corresponding author
      • Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes
        PA Wender; B Lippa; CM Park; K Irie; A Nakahara; H Ohigashi
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jun. 1999, Peer-reviewed
      • Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma
        H Fukuda; K Irie; A Nakahara; H Ohigashi; PA Wender
        BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 1999, Peer-reviewed, Corresponding author
      • Mapping phorbol ester binding domains of protein kinase C (PKC): The design, synthesis and biological activity of novel phorbol ester dimers
        PA Wender; MFT Koehler; DL Wright; K Irie
        SYNTHESIS-STUTTGART, 1999, Peer-reviewed
      • Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma
        H Fukuda; K Irie; A Nakahara; K Oie; H Ohigashi; PA Wender
        TETRAHEDRON LETTERS, Oct. 1998, Peer-reviewed, Corresponding author
      • Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces
        K Irie; Y Nakagawa; S Tomimatsu; H Ohigashi
        TETRAHEDRON LETTERS, Oct. 1998, Peer-reviewed, Lead author, Corresponding author
      • Molecular basis for protein kinase C isozyme-selective binding: The synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes
        K Irie; K Oie; A Nakahara; Y Yanai; H Ohigashi; PA Wender; H Fukuda; H Konishi; U Kikkawa
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1998, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V
        Y Nakagawa; K Irie; Y Nakamura; H Ohigashi; H Hayashi
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 1998, Peer-reviewed, Corresponding author
      • The chemistry-medicine continuum: Synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads
        PA Wender; Y Martin-Cantalejo; AJ Carpenter; A Chiu; J De Brabander; PG Harran; JM Jimenez; MFT Koehler; B Lippa; JA Morrison; SG Muller; SN Muller; CM Park; M Shiozaki; C Siedenbiedel; DJ Skalitzky; M Tanaka; K Irie
        PURE AND APPLIED CHEMISTRY, Mar. 1998, Peer-reviewed
      • ビオチンを用いた新しい光アフィニティーラベリング法の開発と応用
        入江 一浩
        化学と工業, 51/10, 1634, 1998, Lead author, Corresponding author
      • プロテインキナーゼ機能ドメインの化学合成
        入江 一浩
        バイオサイエンスとインダストリー, 56/8, 541-544, 1998, Peer-reviewed, Lead author, Corresponding author
      • Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma
        K Irie; Y Yanai; K Oie; J Ishizawa; Y Nakagawa; H Ohigashi; PA Wender; U Kikkawa
        BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 1997, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V
        Y Nakagawa; K Irie; Y Nakamura; H Ohigashi; H Hayashi
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Aug. 1997, Peer-reviewed, Corresponding author
      • Protein kinase C regulatory domain surrogate peptides: Effects of metal ions on folding, phorbol ester-binding, and selectivity
        K Irie; Y Yanai; K Oie; H Ohigashi; PA Wender
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Apr. 1997, Peer-reviewed, Lead author, Corresponding author
      • Function and role of two zinc finger motives of protein kinase C.
        IRIE Kazuhiro
        KAGAKU TO SEIBUTSU, 1997, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C
        Y Yanai; K Irie; H Ohigashi; PA Wender
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jan. 1997, Peer-reviewed, Corresponding author
      • Synthesis and characterization of model peptides incorporating the phorbol ester-binding domain of protein kinase C
        K Irie; H Ohigashi
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Dec. 1996, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: Elucidation of the biologically active conformation of the tumor-promoting teleocidins
        K Irie; T Isaka; Y Iwata; Y Yanai; Y Nakamura; F Koizumi; H Ohigashi; PA Wender; Y Satomi; H Nishino
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 1996, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C
        K Irie; T Ishii; H Ohigashi; PA Wender; BL Miller; N Takeda
        JOURNAL OF ORGANIC CHEMISTRY, Mar. 1996, Peer-reviewed, Lead author, Corresponding author
      • Synthesis and characterization of the second cysteine-rich region of mouse skin PKC eta
        K Irie; Y Yanai; H Ohigashi; PA Wender; BL Miller
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Feb. 1996, Peer-reviewed, Lead author, Corresponding author
      • プロテインキナーゼCのホルボールエステル結合部位の合成と化学的特性
        入江 一浩; 大東 肇
        有機合成化学協会誌, 54/12, 1024-1033, 1996, Peer-reviewed, Lead author, Corresponding author
      • プロテインキナーゼCのホルボールエステル結合部位の光アフィニティーテベリングによる構造解析
        入江 一浩
        生化学, 68/2, 129-132, 1996, Peer-reviewed, Lead author, Corresponding author
      • Photocytotoxicity of water-soluble fullerene derivatives
        K. Irie; Y. Nakamura; H. Ohigashi; H. Tokuyama; S. Yamago; E. Nakamura
        Biosci. Biotechnol. Biochem., 60/8, 1359-1361, 1996, Peer-reviewed, Lead author, Corresponding author
      • SYNTHESIS OF 6-SUBSTITUTED INDOLACTAMS BY MICROBIAL CONVERSION
        K IRIE; M IGUCHI; T ODA; Y SUZUKI; S OKUNO; H OHIGASHI; K KOSHIMIZU; H HAYASHI; M ARAI; H NISHINO; A IWASHIMA
        TETRAHEDRON, May 1995, Peer-reviewed, Lead author, Corresponding author
      • SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF NEW CONFORMATIONALLY FIXED ANALOGS OF (-)-INDOLACTAM-V, THE CORE STRUCTURE OF TUMOR-PROMOTING TELEOCIDINS
        K IRIE; F KOIZUMI; Y IWATA; T ISHII; Y YANAI; Y NAKAMURA; H OHIGASHI; PA WENDER
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 1995, Peer-reviewed, Lead author, Corresponding author
      • IDENTIFICATION, ACTIVITY, AND STRUCTURAL STUDIES OF PEPTIDES INCORPORATING THE PHORBOL ESTER-BINDING DOMAIN OF PROTEIN-KINASE-C
        PA WENDER; K IRIE; BL MILLER
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 1995, Peer-reviewed
      • NEW TELEOCIDIN-RELATED METABOLITES, (-)-7-GERANYLINDOLACTAM-V AND BLASTMYCETIN-F, FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        K IRIE; SI KAJIYAMA; S OKUNO; M KONDO; K KOSHIMIZU; H HAYASHI; M ARAI; H NISHINO; A IWASHIMA
        JOURNAL OF NATURAL PRODUCTS, Mar. 1994, Peer-reviewed, Lead author, Corresponding author
      • SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF FLUORINE-SUBSTITUTED (-)-INDOLACTAM-V, THE CORE STRUCTURE OF TUMOR PROMOTER TELEOCIDINS
        S OKUNO; K IRIE; Y SUZUKI; K KOSHIMIZU; H NISHINO; A IWASHIMA
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Feb. 1994, Peer-reviewed, Corresponding author
      • Chemical Studies on Tumor Promoter Teleocidins : Structure-Activity Relationship and Phtoaffinity Labeling
        Irie Kazuhiro
        Journal of the Agricultural Chemical Society of Japan, 1994, Peer-reviewed, Lead author, Corresponding author
      • PHOTOLABILE DERIVATIVES OF INDOLE ALKALOID TUMOR PROMOTER TELEOCIDINS - SYNTHESIS, BIOLOGICAL-ACTIVITIES AND PHOTOAFFINITY-LABELING STUDIES
        K IRIE; S OKUNO; F KOIZUMI; K KOSHIMIZU; H NISHINO; A IWASHIMA
        TETRAHEDRON, Nov. 1993, Peer-reviewed, Lead author, Corresponding author
      • SYNTHESIS AND BINDING OF PHOTOAFFINITY LIGAND CANDIDATES FOR PROTEIN-KINASE-C
        PA WENDER; K IRIE; BL MILLER
        JOURNAL OF ORGANIC CHEMISTRY, Jul. 1993, Peer-reviewed
      • PHOTOCYTOTOXICITY OF WATER-SOLUBLE METALLOPORPHYRIN DERIVATIVES
        T ANDO; K IRIE; K KOSHIMIZU; T TAKEMURA; H NISHINO; A IWASHIMA; N TAKEDA; S NAKAJIMA; SAKATA, I
        PHOTOCHEMISTRY AND PHOTOBIOLOGY, Apr. 1993, Peer-reviewed, Corresponding author
      • Chemistry of indole alkaloid tumor promoter teleocidins
        K. Irie; K. Koshimizu
        Comments Agric. & Food Chemistry,3/1, 1-25, 1993, Peer-reviewed, Lead author, Corresponding author
      • A CONVENIENT SYNTHESIS OF CHLORIN E6 DIMER AND TRIMER
        T ANDO; K IRIE; K KOSHIMIZU; S NAKAJIMA; T TAKEMURA; SAKATA, I
        PHOTODYNAMIC THERAPY AND BIOMEDICAL LASERS, 1992, Peer-reviewed, Corresponding author
      • THE INDOLE ALKALOID TUMOR PROMOTER TELEOCIDINS AS EPSTEIN-BARR-VIRUS INDUCERS - STRUCTURE, BIOSYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP
        K IRIE; K KOSHIMIZU
        NATURAL PRODUCTS AS ANTIVIRAL AGENTS, 1992, Peer-reviewed, Lead author, Corresponding author
      • 腫瘍親和性光増感剤ヘマトポルフィリン誘導体の活性成分は?
        入江 一浩; 小清水 弘一
        化学, 47/2, 142, 1992, Lead author, Corresponding author
      • INVESTIGATION OF STRUCTURE-ACTIVITY-RELATIONSHIPS USING TELEOCIDIN DERIVATIVES TO ELUCIDATE THE MECHANISM OF TUMOR PROMOTION
        K IRIE; K KOSHIMIZU
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Nov. 1991, Peer-reviewed, Lead author, Corresponding author
      • QUANTITATIVE STRUCTURE ACTIVITY STUDIES ON INDOLE ALKALOID TUMOR PROMOTER INDOLACTAM CONGENERS
        K IRIE; S OKUNO; S KAJIYAMA; K KOSHIMIZU; H NISHINO; A IWASHIMA
        CARCINOGENESIS, Oct. 1991, Peer-reviewed, Lead author, Corresponding author
      • NEW WATER-SOLUBLE PYROPHEOPHORBIDE A DERIVATIVES AS POSSIBLE AGENTS FOR PHOTODYNAMIC THERAPY OF CANCER
        T ANDO; Y SUZUKI; R GEKA; K IRIE; K KOSHIMIZU; T TAKEMURA; S NAKAJIMA; SAKATA, I
        TETRAHEDRON LETTERS, Sep. 1991, Peer-reviewed, Corresponding author
      • NEW PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY - SYNTHESES OF CHLORIN-E6 DIMER AND TRIMER
        T ANDO; K IRIE; K KOSHIMIZU; T SHINGU; N TAKEDA; T TAKEMURA; S NAKAJIMA; SAKATA, I
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Sep. 1991, Peer-reviewed, Corresponding author
      • SYNTHESIS OF NEW INDOLACTAM ANALOGS BY MICROBIAL CONVERSION
        S KAJIYAMA; K IRIE; T KIDO; K KOSHIMIZU; H HAYASHI; M ARAI
        TETRAHEDRON, Jul. 1991, Peer-reviewed, Corresponding author
      • 発癌プロモーターの作用機作解明への有機化学的アプローチ
        入江 一浩; 小清水 弘一
        有機合成化学協会誌, 49/11, 1070-1079, 1991, Peer-reviewed, Lead author
      • SUPPRESSION BY PROTEIN-KINASE-C INHIBITORS OF TUMOR PROMOTER ENHANCEMENT OF EPSTEIN-BARR VIRUS-INDUCED GROWTH TRANSFORMATION
        T KINOSHITA; TAKAHASHI, I; E KOBAYASHI; T TAMAOKI; K IRIE; K KOSHIMIZU; T OSATO
        ANTICANCER RESEARCH, Jul. 1990, Peer-reviewed
      • SYNTHESES AND BIOLOGICAL-ACTIVITIES OF PHOTOLABILE INDOLACTAM DERIVATIVES - NEW PROBES FOR THE RECEPTOR ANALYSIS OF TUMOR PROMOTERS
        S OKUNO; K IRIE; H NISHINO; A IWASHIMA; K KOSHIMIZU
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jul. 1990, Peer-reviewed, Corresponding author
      • SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND PHOTOCYTOTOXICITY OF 5 NEW DELTA-SUBSTITUTED CHLORIN-E6 DERIVATIVES
        T ANDO; K IRIE; K KOSHIMIZU; T TAKEMURA; H NISHINO; A IWASHIMA; S NAKAJIMA; SAKATA, I
        TETRAHEDRON, 1990, Peer-reviewed, Corresponding author
      • ISOLATION AND BIOSYNTHESIS OF (-)-INDOLACTAM-I, A NEW CONGENER OF INDOLE ALKALOID TUMOR PROMOTER TELEOCIDINS
        K IRIE; S KAJIYAMA; K KOSHIMIZU; H HAYASHI; M ARAI
        TETRAHEDRON LETTERS, 1990, Peer-reviewed, Lead author, Corresponding author
      • BIOSYNTHESIS OF INDOLE ALKALOID TUMOR PROMOTERS TELEOCIDINS .1. POSSIBLE BIOSYNTHETIC-PATHWAY OF THE MONOTERPENOID MOIETIES OF TELEOCIDINS
        K IRIE; S KAJIYAMA; A FUNAKI; K KOSHIMIZU; H HAYASHI; M ARAI
        TETRAHEDRON, 1990, Peer-reviewed, Lead author
      • BIOSYNTHESIS OF (-)-INDOLACTAM-V, THE BASIC RING-STRUCTURE OF TUMOR PROMOTERS TELEOCIDINS
        K IRIE; S KAJIYAMA; A FUNAKI; K KOSHIMIZU; H HAYASHI; M ARAI
        TETRAHEDRON LETTERS, 1990, Peer-reviewed, Lead author
      • BIOLOGICAL-ACTIVITIES AND CELLULAR UPTAKE STUDIES OF FLUORESCENT DERIVATIVES OF INDOLE ALKALOID TUMOR PROMOTER TELEOCIDIN
        K IRIE; S OKUNO; K KOSHIMIZU; H TOKUDA; H NISHINO; A IWASHIMA
        INTERNATIONAL JOURNAL OF CANCER, Mar. 1989, Peer-reviewed, Lead author
      • Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins
        K. Koshimizu; K. Irie
        Hokkaido Univ. Med. Lib. Ser., 24, 111-134, 1989, Peer-reviewed
      • STRUCTURE OF BLASTMYCETIN-E, A NEW TELEOCIDIN-RELATED COMPOUND, FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        K IRIE; A FUNAKI; K KOSHIMIZU; H HAYASHI; M ARAI
        TETRAHEDRON LETTERS, 1989, Peer-reviewed, Lead author
      • ISOLATION AND BIOLOGICAL-ACTIVITIES OF N13-DESMETHYL ANALOGS OF TUMOR PROMOTER TELEOCIDIN FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        K IRIE; N HAGIWARA; A FUNAKI; H HAYASHI; M ARAI; H TOKUDA; K KOSHIMIZU
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Dec. 1988, Peer-reviewed, Lead author
      • STRUCTURE AND TUMOR-PROMOTING ACTIVITY OF NEW TELEOCIDIN-RELATED METABOLITES (BLASTMYCETINS) FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        N HAGIWARA; K IRIE; A FUNAKI; H HAYASHI; M ARAI; K KOSHIMIZU
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Mar. 1988, Peer-reviewed
      • Structure-activity studies of indole alkaloid tumor promoters
        K. Irie; K. Koshimizu
        Mem. Coll. Agric., Kyoto Univ.,132, 1-59, 1988, Peer-reviewed, Lead author
      • THE METABOLISM OF INDOLE ALKALOID TUMOR PROMOTER, (-)-INDOLACTAM-V, WHICH HAS THE FUNDAMENTAL STRUCTURE OF TELEOCIDINS, BY RAT-LIVER MICROSOMES
        N HAGIWARA; K IRIE; H TOKUDA; K KOSHIMIZU
        CARCINOGENESIS, Jul. 1987, Peer-reviewed
      • ISOLATION OF BLASTMYCETIN-D, A POSSIBLE PRECURSOR OF TELEOCIDINS, FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        K IRIE; N HAGIWARA; A FUNAKI; H HAYASHI; M ARAI; K KOSHIMIZU
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jun. 1987, Peer-reviewed, Lead author
      • STRUCTURE - ACTIVITY STUDIES OF THE INDOLE ALKALOID TUMOR PROMOTER TELEOCIDINS
        K IRIE; N HAGIWARA; H TOKUDA; K KOSHIMIZU
        CARCINOGENESIS, Apr. 1987, Peer-reviewed, Lead author
      • QUANTITATIVE STRUCTURE ACTIVITY STUDIES OF BENZOYLPHENYLUREA LARVICIDES .3. EFFECTS OF SUBSTITUENTS AT THE BENZOYL MOIETY
        Y NAKAGAWA; T SOTOMATSU; K IRIE; K KITAHARA; H IWAMURA; T FUJITA
        PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Feb. 1987, Peer-reviewed
      • Teleocidin Structure-Activity Studies of Teleocidins
        Kazuhiro Irie
        Nippon Nogeikagaku Kaishi, 1987, Peer-reviewed
      • NEW PROBES FOR RECEPTOR ANALYSIS OF TUMOR PROMOTERS SYNTHESIS OF FLUORESCENT DERIVATIVES OF (-)-INDOLACTAM-V, THE BASIC RING-STRUCTURE OF TELEOCIDINS
        K IRIE; N HAGIWARA; K KOSHIMIZU
        TETRAHEDRON, 1987, Peer-reviewed, Lead author
      • SYNTHESIS OF A BIOLOGICALLY-ACTIVE FLUORESCENT INDOLACTAM DERIVATIVE - A METHOD OF PREPARING NEW PROBES FOR RECEPTOR ANALYSIS OF TUMOR PROMOTERS
        K IRIE; N HAGIWARA; K KOSHIMIZU
        TETRAHEDRON LETTERS, 1987, Peer-reviewed, Lead author
      • NEW TELEOCIDIN-RELATED METABOLITES FROM STREPTOVERTICILLIUM-BLASTMY-CETICUM PRODUCING TUMOR-PROMOTING INDOLE ALKALOIDS
        K IRIE; N HAGIWARA; T KUROME; H HAYASHI; M ARAI; K KOSHIMIZU
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jan. 1987, Peer-reviewed, Lead author
      • SUBSTITUTION-REACTION ON THE INDOLE RING OF (-)-INDOLACTAM-V, THE FUNDAMENTAL STRUCTURE OF TELEOCIDINS
        K IRIE; H HAYASHI; M ARAI; K KOSHIMIZU
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Oct. 1986, Peer-reviewed, Lead author
      • 微生物の生産する発癌プロモーター
        入江 一浩; 小清水 弘一
        日本放線菌学会誌,49, 3-9, 1986, Peer-reviewed
      • STRUCTURE-ACTIVITY RELATIONSHIP IN THE INDUCTION OF EPSTEIN-BARR VIRUS BY TELEOCIDIN DERIVATIVES
        K IRIE; H TOKUDA; N HAGIWARA; K KOSHIMIZU; H HAYASHI; S MURAO; Y ITO
        INTERNATIONAL JOURNAL OF CANCER, 1985, Peer-reviewed, Lead author
      • NEW TELEOCIDIN METABOLITES FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        N HAGIWARA; K IRIE; K KOSHIMIZU; H HAYASHI; S MURAO; H TOKUDA; Y ITO
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed
      • EPSTEIN-BARR VIRUS EARLY ANTIGEN INDUCING ACTIVITY OF 14-O-DERIVATIVES OF (-)-INDOLACTAM-V
        K IRIE; N HAGIWARA; K KOSHIMIZU; H TOKUDA; Y ITO; H HAYASHI; S MURAO
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed, Lead author
      • TUMOR PROMOTING ACTIVITIES OF NEW SYNTHETIC ANALOGS OF TELEOCIDIN
        H FUJIKI; M SUGANUMA; H HAKII; M NAKAYASU; Y ENDO; K SHUDO; K IRIE; K KOSHIMIZU; T SUGIMURA
        PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1985, Peer-reviewed
      • IDENTIFICATION OF THE MICROORGANISM WHICH PRODUCES EPSTEIN-BARR VIRUS EARLY ANTIGEN-INDUCING INDOLE ALKALOIDS
        K IRIE; N HAGIWARA; K KOSHIMIZU; H HAYASHI; S MURAO; Y ITO
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed, Lead author
      • ISOLATION AND THE EPSTEIN-BARR VIRUS EARLY ANTIGEN INDUCING ACTIVITY OF OLIVORETINS FROM STREPTOVERTICILLIUM-BLASTMYCETICUM
        K IRIE; N HAGIWARA; K KOSHIMIZU; H HAYASHI; S MURAO; H TOKUDA; Y ITO
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed, Lead author
      • THE EPSTEIN-BARR VIRUS EARLY ANTIGEN INDUCING INDOLE ALKALOIDS, (-)-INDOLACTAM-V AND ITS RELATED-COMPOUNDS, PRODUCED BY ACTINOMYCETES
        K IRIE; M HIROTA; N HAGIWARA; K KOSHIMIZU; H HAYASHI; S MURAO; H TOKUDA; Y ITO
        AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1984, Peer-reviewed, Lead author

      Misc.

      • アロタケタール単純化アナログの設計・合成およびPKC結合活性
        眞木準平; 押村亜沙美; 塚野千尋; 柳田 亮; 齋藤 裕; 榊原康文; 入江一浩
        第51回複素環化学討論会(大阪大学コンベンションセンター、吹田市), Sep. 2022, Last author, Corresponding author
      • Asymmetric total synthesis and structure revision of lancilactone C, and anti-HIV triterpenoid
        Chihiro Tsukano; Hidetaka Kuroiwa; Soichiro Suzuki; Kazuhiro Irie
        The 64th Symposium on the Chemistry of Natural Products, Sep. 2022, Peer-reviewed, Last author
      • Synthetic studies on aculeines, peptide toxins post-translationally modified by long-chain plolyamines
        Raku Irie; Masayoshi Miyahara; Sara Takaki; Ryoya Wakabayashi; Chisato Tani; Satoko Matsunaga; Yumi Irie; Makoto Inai; Hitoshi Ouchi; Kazuhiro Irie; Ryuichi Sakai; Toshiyuki Kan; Masato Oikawa
        The 64th Symposium on The Chemistry of Natural Products, Sep. 2022, Peer-reviewed
      • Development of a conformation specific antibody identifying toxic conformation of amyloid β peptide
        Y. Kageyama; Y. Irie; Y. Matsushima; T. Segawa; D. Kaneda; Y. Hashizume; H. Akatsu; K. Miki; A. Kita; K. Irie; I. Tooyama
        第63回日本神経病理学会総会学術研究会, Jun. 2022
      • Toxic amyloid β42 conformer may accelerate the onset of Alzheimer’s disease in the preclinical stage
        A. Futamura; S. Hieda; Y. Mori; K. Kasuga; A. Sugimoto; H. Kasai; T. Kuroda; S. Yano S; M. Tsuji; T. Ikeuchi; K. Irie; K. Ono
        第63回日本神経学会学術集会, May 2022
      • (–)-Carvoneを用いるAplysiatoxin単純化アナログの合成と活性評価
        鈴木芳幸; 守時恵一; 梶原瑞生; 柳田 亮; 川浪康弘; 花木祐輔; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author
      • B環を除去したAplysiatoxin単純化アナログの合成と生物活性
        関戸智紀; 山本剛史; 柳田 亮; 花木祐輔; 川浪康弘; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author
      • 機能性食品成分に含まれるフラボノイド抱合体の合成とアミロイドβ42に対する凝集阻害活性
        谷輪厚太; 村上一馬; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author
      • 主成分分析を活用したLC-MSによるアミロイドβ凝集阻害剤の効率的探索法
        花木瑞穂; 村上一馬; 郡司裕樹; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author
      • Pre-schisanartanin Aの右側フラグメント合成
        八木田凌太郎; 入江一浩; 塚野千尋
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022
      • アロタケタール類のシスピラン環型単純化アナログの合成とPKC結合活性
        奥田創元; 塚野千尋; 柳田 亮; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author, Corresponding author
      • アロタケタール類のトランスデカリン型単純化アナログの合成とPKC結合活性
        眞木準平; 押村亜沙美; 塚野千尋; 柳田 亮; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author, Corresponding author
      • アミロイドβの毒性2量体モデルにおけるリンカー長の凝集能と細胞毒性に及ぼす影響
        筑後文馨; 入江由美; 内野歩美; 塚野千尋; 川瀬泰司; 廣瀬賢治; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author, Corresponding author
      • 3回対称ならびに平行型Aβ40の3量体モデルの合成と機能解析
        内野歩美; 入江由美; 塚野千尋; 川瀬泰司; 廣瀬賢治; 入江一浩
        2022年度日本農芸化学会大会(京都)、オンライン開催, Mar. 2022, Last author, Corresponding author
      • サネカズラ属生薬植物由来の抗HIV活性トリテルペノイド・Lancilactone Cの不斉全合成研究
        黒岩秀崇; 入江一浩; 塚野千尋
        日本農芸化学会関西支部第519回講演会(京都)、オンライン開催, Feb. 2022, Last author
      • Studies toward synthesis of aculeine B, a cytotoxic peptide-polyamine conjugate from marine sponges
        Oikawa, M; Miyahara, M; Nakamura, S; Honda, A; Sakai, R; Irie, Y; Irie, K; Irie R
        PACIFICHEM 2021 (virtual), Dec. 2021
      • Synthesis and biological activities of des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin
        Yanagita, R. C; Ashida, Y; Kawanami, Y; Mutsumi, O; Dan, S; Irie, K
        PACIFICHEM 2021 (virtual), Dec. 2021, Last author
      • Development of new protein kinase C ligands using a machine learning model
        Irie, K; Tsukano, C; Maki, J; Oshimura, A; Okuda, S; Gonda, A; Yanagita, R. C; Saito, Y; Sakakibara, Y
        PACIFICHEM 2021 (virtual), Dec. 2021, Invited, Lead author, Corresponding author
      • Classification of amyloid beta aggregation inhibitors from natural product library
        Murakami, K; Horii, S; Sadamitsu, T; Sakaguchi, Y; Taniwa, K; Hanaki, M; Gunji, H; Irie, K
        PACIFICHEM 2021 (virtual), Dec. 2021, Last author
      • Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with a steroid toward antisense oligonucleotide therapy
        Murakami, K; Yagita, R; Ikeda, H; Irie, K
        PACIFICHEM 2021 (virtual), Dec. 2021, Last author
      • Suppression of toxic amyloid β42 oligomers in rat primary cerebral cortex cells and human iPS-derived neurons treated with 10-Me-Aplog-1, a new PKC activator
        Murakami, K; Yoshimura, M; Nakagawa, S; Kume, T; Kondo, T; Inoue, H; Irie, K
        PACIFICHEM 2021 (virtual), Dec. 2021, Last author
      • Toxic amyloid β42 conformer may accelerate the onset of Alzheimer’s disease in the preclinical stage
        Futamata, A; Hieda, S; Mori, Y; Kasuga, K; Sugimoto, A; Kasai, H; Kuroda, T; Yano, S; Tsuji, M; Ikeuchi, T; Irie, K; Ono, K
        第40回日本認知症学会学術集会(東京国際フォーラム、ハイブリッド), Nov. 2021
      • 大阪変異のAβ 毒性コンホマー形成能に与えるプロリン置換の影響
        村上一馬; 山口智美; 泉尾直孝; 久米利明; 原 英之; 入江一浩
        第40回日本認知症学会学術集(東京国際フォーラム、ハイブリッド), Nov. 2021, Last author
      • 朝鮮五味子由来ノルトリテルペノイドの左側フラグメント合成
        八木田凌太郎; 入江一浩; 塚野千尋
        第50回複素環討論会、静岡市清水文化会館(静岡市), Oct. 2021
      • Asymmetric total synthesis of shagenes A and B, tricyclic sesquiterpenes
        Chihiro Tsukano; Ryotaro Yagita; Takayoshi Heike; Tagwa A. Mohammed; Kazuya Nishibayashi; Kazuhiro Irie; Yoshiji Takemoto
        The 63rd Symposium on THE CHEMISTRY OF NATURAL PRODUCTS, Sep. 2021
      • Classification of amyloid β42 aggregation modulators from natural product library identifies promising scaffolds that suppress nuclei-driven neurotoxicity
        Kazuma Murakami; Shiori Horii; Mizuho Hanaki; Kazuhiro Irie
        Alzheimer’s Association International Conference 2021 (online, poster), Jul. 2021, Last author, Corresponding author
      • アミロイドタンパク質を認識するRNAアプタマーの治療・診断応用に向けて
        村上一馬; 小畑弥生; 入江一浩
        日本核酸医薬学会第6回年会, Jun. 2021, Last author
      • セージからのジテルペン型AhRリガンドの単離、同定
        西野勝俊; 染谷健太; Riadh Ksouri; 石川敏夫; 礒田博子; 入江一浩; 永尾雅哉
        2021年度日本農芸化学会大会(オンライン), Mar. 2021
      • 青ジソに含まれるアミロイドβ42の凝集阻害物質・DDCの代謝物の合成と活性
        谷輪厚太; 村上一馬; 坂口嘉紀; 入江一浩
        2021年度日本農芸化学会大会(オンライン), Mar. 2021, Last author, Corresponding author
      • アンチセンス治療を指向した長鎖ペプチド核酸の合成研究
        村上一馬; 八木田凌太郎; 池田壽文; 入江一浩
        2021年度日本農芸化学会大会(オンライン), Mar. 2021, Last author, Corresponding author
      • CH/π相互作用に着目したAplysiatoxin単純化アナログの分子動力学解析
        柳田 亮; 小林巧美; 権田敦子; 高田晃児; 入江一浩
        2021年度日本農芸化学会大会(オンライン), Mar. 2021, Last author, Corresponding author
      • Pre-schisanartanin Aの不斉全合成研究
        八木田凌太郎; 塚野千尋; 入江一浩
        2021年度日本農芸化学会大会(オンライン), Mar. 2021
      • 抗HIV活性トリテルペノイド・ランシラクトンCの不斉全合成研究
        黒岩秀崇; 塚野千尋; 入江一浩
        2021年度日本農芸化学会大会(オンライン), Mar. 2021
      • 病原性凝集ペプチドの3量体モデルのリンカーとなるアルキル架橋トリス-α-アミノ酸の合成
        内野歩美; 塚野千尋; 今本恒雄; 入江一浩
        2021年度日本農芸化学会大会(オンライン), Mar. 2021, Last author, Corresponding author
      • セージ(Salvia officinalis)からのapoA-Iを介するコレステロール搬出促進化合物の単離・同定
        平島知代子、染谷健太、西野勝俊、Riadh Ksouri、松尾道憲、礒田博子、入江一浩、永尾雅哉
        日本農芸化学会関西支部例会(第514回講演会)オンライン, Feb. 2021
      • カワラケツメイからのカテプシンK阻害物質の単離・同定
        佐藤 峻、西野勝俊、入江一浩、大塚隆尚、永尾雅哉
        日本農芸化学会関西支部例会(第514回講演会)オンライン, Feb. 2021
      • 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの最適化
        松島由佳; 入江一浩
        日本農芸化学会関西支部例会(第514回講演会)オンライン, Feb. 2021, Last author, Corresponding author
      • B環を除去したAplysiatoxin単純化アナログの合成研究
        山本剛資; 柳田 亮; 川浪康弘; 入江一浩
        日本農芸化学会中四国支部第58回講演会, Jan. 2021, Last author
      • Identification of aryl hydrocarbon receptor ligands from Salvia officinalis leaves
        西野勝俊; 染谷健太; RIADH Ksouri; 石川敏夫; 礒田博子; 礒田博子; 入江一浩; 永尾雅哉
        日本農芸化学会大会講演要旨集(Web), 2021
      • アミロイドβのパースルフィド化に関する化学研究
        村上一馬、加藤春花、花木瑞穂、物部容子、赤木謙一、川瀬泰司、廣瀬賢治、入江一浩
        第39回日本認知症学会学術集会(オンライン開催), Nov. 2020, Last author, Corresponding author
      • 分子内ジスルフィド結合形成によるアミロイドβ42毒性配座固定モデルの合成および活性評価
        松島由佳、柳田 亮、入江一浩
        第39回日本認知症学会学術集会(オンライン開催), Nov. 2020, Last author, Corresponding author
      • RNA Aptamers as a recognizing tool of toxic oligomer of amyloid beta42
        Kazuma Murakami; Yayoi Obata; Asa Sekikawa; Haruka Ueda; Taiji Kawase; Kenji Hirose; Naotaka Izuo; Takahiko Shimizu; Kazuhiro Irie
        62nd Symposium on the chemistry of natural products, Sep. 2020, Peer-reviewed, Last author, Corresponding author
      • Synthetic studies on aculeine B, a peptide–polyamine hybrid marine toxin
        宮原正義;入江 樂;酒井隆一;入江由美;入江一浩;及川雅人
        日本化学会 第100回春季年会(東京理科大学)講演要旨公表のみ, Mar. 2020
      • Debromoaplysiatoxin単純化アナログ・10-Me-Aplog-1の側鎖長の最適化
        権田敦子、高田晃児、入江一浩
        2020年度日本農芸化学会大会(九州大学、福岡市)講演要旨公表のみ, Mar. 2020, Last author, Corresponding author
      • CH/π相互作用に着目したaplysiatoxin単純化アナログの合成と生物活性
        小林巧実、入江一浩
        2020年度日本農芸化学会大会(九州大学、福岡市)講演要旨公表のみ, Mar. 2020, Last author, Corresponding author
      • Shagene AおよびBの不斉全合成研究
        八木田凌太郎、西林和也、Mohammed Tagwa、平家崇吉、竹本佳司、入江一浩、塚野千尋
        2020年度日本農芸化学会大会(九州大学、福岡市)講演要旨公表のみ, Mar. 2020
      • アミロイドβの凝集阻害機構に基づいた天然物ライブラリーの分類
        村上一馬; 堀井詩織; 定光達斗; 花木瑞穂; 郡司祐樹; 入江一浩
        2020年度日本農芸化学会大会(九州大学、福岡市)講演要旨公表のみ, Mar. 2020, Last author
      • 地中海沿岸原産植物からのAhRリガンドの単離・同定
        染谷健太; 西野勝俊; KSOURI Riadh; 石川敏夫; 礒田博子; 礒田博子; 入江一浩; 永尾雅哉
        日本農芸化学会関西支部講演会講演要旨集, 2020
      • PKC活性化剤とBET阻害剤の併用によるHIV再活性化能及び毒性への効果
        鷲崎彩夏; 村田めぐみ; 関 洋平; Yin Pui Tang; Tan Wei Keat; 入江一浩; 明里宏文
        第33回 日本エイズ学会学術集会・総会(熊本城ホール、熊本市), Nov. 2019
      • Alzheimer型認知症と対照脳脊髄液中のAβ毒性コンホマーオリゴマー量とタウの関連
        冨所康志、石井一弘、入江一浩、玉岡 晃
        第38回日本認知症学会学術集会(京王プラザホテル、東京), Nov. 2019, Peer-reviewed
      • アミロイドβのプロトフィブリルを認識するRNAアプタマー
        村上一馬; 小畑弥生; 関川あさ; 上田 遥; 泉尾直孝; 粟野達也; 高部圭司; 清水孝彦; 入江一浩
        第38回日本認知症学会学術集会(京王プラザホテル、東京), Nov. 2019, Peer-reviewed, Last author
      • アミロイドβ40の3量体モデルの合成と神経細胞毒性
        入江由美; 花木瑞穂; 村上一馬; 今本恒雄; 古田 巧; 川端猛夫; 川瀬泰司; 廣瀬賢治; 柳田 亮; 入江一浩
        第38回日本認知症学会学術集会(京王プラザホテル、東京), Nov. 2019, Peer-reviewed, Last author, Corresponding author
      • 準安定なアミロイドβの毒性オリゴマーモデルの合成と機能解析
        入江由美、村上一馬、花木瑞穂、花木祐輔、鈴木天志、今本恒雄、古田 巧、川端猛夫、川瀬泰司、廣瀬賢治、柳田 亮、入江一浩
        第61回天然有機化合物討論会(広島国際会議場、広島市), Sep. 2019, Peer-reviewed, Last author, Corresponding author
      • 分子内ジスルフィド結合によるアミロイドβ 42の毒性配座固定アナログの合成と生化学的機能解析
        松島由佳; 村上一馬; 入江一浩
        第9回 認知症研究を知る若手研究者の集まり(ホテルヘリテイジ・リゾート、熊谷市), Aug. 2019, Last author, Corresponding author
      • Aplysiatoxinならびにoscillatoxin類の合成と生物活性評価
        花木祐輔; 新木悠介; 野倉吉彦; 中崎敦夫; 北 将樹; 早川皓太郎; 入江一浩; 西川俊夫
        日本ケミカルバイオロジー学会(ウインクあいち、名古屋市), Jun. 2019
      • Toxic Aβ conformer and tau in CSF obtained from the cases of AD and controls, a preliminary study
        冨所康志、石井一弘、入江一浩、玉岡 晃
        第60回日本神経学会学術大会(大阪府立国際会議場、大阪市), May 2019
      • アミロイドβの凝集を抑制する食品・生薬成分の作用機構
        入江一浩; 村上一馬
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019
      • サンゴジュの花芽に含まれるビブサニン類の分析と生物活性評価
        柳田 亮; 植松紗和子; 西 皓冬; 川浪康弘; 入江一浩
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019, Last author
      • Oscillatoxin Dの全合成と生物活性評価
        花木祐輔、新木悠介、野倉吉彦、中崎敦夫、北 将樹、早川皓太郎、入江一浩、西川俊夫
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019
      • アミロイドβの毒性オリゴマー形成阻害能を有する生薬化合物のカルボキシ基の役割
        堀井詩織; 村上一馬; 花木瑞穂; 粟野達也; 高部圭司; 川瀬泰司; 廣瀬賢治; 入江一浩
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019, Last author, Corresponding author
      • 分子内ジスルフィド結合形成によるアミロイドβ42の毒性配座モデルの合成と機能解析
        松島由佳; 村上一馬; 花木瑞穂; 粟野達也; 高部圭司; 柳田 亮; 入江一浩
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019, Last author, Corresponding author
      • スピロ環をもたないaplysiatoxin単純化アナログの合成とPKCアイソザイム結合活性
        押村亜沙美; 早川皓太郎; 花木祐輔; 柳田 亮; 入江一浩
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019, Last author, Corresponding author
      • アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用
        村上一馬; 小畑弥生; 関川あさ; 上田 遥; 泉尾直孝; 粟野達也; 高部圭司; 清水孝彦; 入江一浩
        2019年度日本農芸化学会大会(東京農大、東京), Mar. 2019, Last author, Corresponding author
      • スピロ環を簡略化したアプリシアトキシン単純化アナログの合成、配座、および生物活性
        柳田 亮; 芦田能基; 川浪康弘; 旦 慎吾; 岡村睦美; 入江一浩
        2018年度先端モデル動物支援プラットフォーム成果発表会(琵琶湖ホテル、大津市), Jan. 2019, Last author
      • Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators
        Yoshimura, M; Murakami, K; Kume, T; Irie, K
        新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)(一橋大学一橋講堂、東京), Jan. 2019, Last author, Corresponding author
      • Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1
        Ashida, Y; Yanagita, R. C; Kawanami, Y; Okamura, M; Dan, S; Irie, K
        新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)、(一橋大学一橋講堂、東京), Jan. 2019, Last author
      • 新規PKC活性化剤10-Methyl-Aplog-1とJQ1の併用はLatency Reversing Agentとして理想的な活性を示す
        鷲崎彩夏; 村田めぐみ; 関洋平; Yin Pui Tang; 寒川裕之; Wei Keat Tan; 入江一浩; 明里宏文
        第32回 日本エイズ学会学術集会, 02 Dec. 2018, Peer-reviewed
      • Aβ42毒性オリゴマーの細胞内標的タンパク質と作用機序
        片岡翔太郎; 村上一馬; 徳田真樹; 泉 俊輔; 入江一浩
        日本農芸化学会2018年度関西支部例会(第506回講演会)(神戸大学、神戸市), Dec. 2018, Last author, Corresponding author
      • Synthetic studies on oscillatoxin D and its analogs
        Hanaki, Y., Araki, Y., Nokura, Y., Nakazaki, A., Kita, M., Irie, K., Nishikawa, T.
        The 14th International Kyoto Conference on New Aspects of Organic Chemistry (Rihga Royal Hotel) (Kyoto, Japan), Nov. 2018
      • 生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価
        塚田健人、金子秋穂、新木翔之、河治久実、児玉栄一、倉石貴透、村上一馬、入江一浩、平田尚也、諫田泰成、浅井禎吾
        第36回メディシナルケミストリーシンポジウム(京都テルサ、京都市), Nov. 2018
      • RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry
        Murakami, K; Obata, Y; Sekikawa, A; Ueda, H; Izuo, N; Awano, T; Takabe, K; Shimizu, T; Irie, K
        The 45th International Syposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall) (Kyoto, Japan), Nov. 2018, Last author, Corresponding author
      • A novel PKC activator 10-Methyl-Aplog-1 in combination with JQ1 showed high potency as LRA for shock and kill therapy
        Ayaka Washizaki; Megumi Murata; Yohei Seki; Yin Pui Tang; Hiroyuki Kangawa; Kazuhiro Irie; Hirofumi Akari
        66th Annual Meeting of the Japanese Society for Virology, 28 Oct. 2018, Peer-reviewed
      • 脳脊髄液中のAβ毒性コンホマー量とタウの関連
        冨所康志、石井一弘、入江一浩、玉岡 晃
        第37回日本認知症学会学術集会(ロイトン札幌・札幌市教育文化会館、札幌市), Oct. 2018
      • 天然物によるアミロイドβの毒性オリゴマー形成阻害機構
        村上一馬; 吉岡卓也; 堀井詩織; 花木瑞穂; 緑川論弘; 谷脇慎治; 郡司祐樹; 赤木謙一; 川瀬泰司; 廣瀬賢治; 入江一浩
        第37回日本認知症学会学術集会(ロイトン札幌・札幌市教育文化会館、札幌市), Oct. 2018, Last author, Corresponding author
      • 分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御
        松島由佳; 村上一馬; 花木瑞穂; 粟野達也; 高部圭司; 柳田 亮; 入江一浩
        第37回日本認知症学会学術集会(ロイトン札幌・札幌市教育文化会館、札幌市), Oct. 2018, Last author, Corresponding author
      • 新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す
        鷲崎彩夏; 村田めぐみ; 関 洋平; Yin Pui Tang; 寒川裕之; 入江一浩; 明里宏文
        第66回日本ウイルス学会学術集会(京都テルサ、京都市), Oct. 2018
      • 抗腫瘍性Aplysiatoxin単純化アナログ・10-Me-Aplog-1のアセタール型アナログの合成と生物活性
        早川皓太郎; 花木祐輔; 徳田春邦; 柳田 亮; 中川 優; 入江一浩
        第60回天然有機化合物討論会、久留米シティープラザ(福岡県久留米市), Sep. 2018, Peer-reviewed, Last author, Corresponding author
      • サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測
        植松紗和子、柳田 亮、三宅翔太、川浪康弘、入江一浩
        日本農芸化学会2018年度中四国支部大会(島根大学松江キャンパス、松江市), Sep. 2018
      • アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー
        小畑弥生; 村上一馬; 関川あさ; 粟野達也; 髙部圭司; 入江一浩
        日本核酸医薬学会第4回年会(九州大学医学部百年講堂、福岡市), Jul. 2018, Last author
      • 新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す
        鷲崎彩夏; 村田めぐみ; 関 洋平; Yin Pui Tang; 寒川裕之; Tan Wei Keat; 入江一浩; 明里宏文
        第32回近畿エイズ研究会学術集会(大阪大学微生物病研究所、吹田市), Jun. 2018
      • Toxic Aβ conformer and tau in CSF obtained from the cases of AD dementia, a preliminary study
        冨所康志、石井一弘、入江一浩、玉岡 晃
        第59回日本神経学会学術大会(札幌市教育文化会館、札幌市), May 2018
      • アミロイドβの毒性オリゴマーの構造解析に基づくアルツハイマー病の早期診断法の開発
        IRIE Kazuhiro
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Invited, Lead author, Corresponding author
      • スピロ環をもたないアプリシアトキシン単純化アナログの合成、配座、および活性
        芦田能基; 柳田 亮; 川浪康弘; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author
      • 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝
        坂口嘉紀; 村上一馬; 花木瑞穂; 泉尾直孝; 小澤祐介; 粟野達也; 高部圭司; 川瀬泰司; 廣瀬賢治; 三羽伸明; 久米利明; 清水孝彦; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • アプリシアトキシン単純化アナログ・10-Me-aplog-1の側鎖誘導体の合成と活性
        高田晃児; 花木祐輔; 菊森将之; 徳田春邦; 柳田 亮; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • アプリシアトキシン単純化アナログ・10-Me-Aplog-1の3位アセタール型アナログの合成
        早川皓太郎; 花木祐輔; 徳田春邦; 柳田 亮; 中川 優; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発
        小畑弥生; 村上一馬; 関川あさ; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • アミロイドβ42の毒性オリゴマーの細胞内標的探索
        片岡翔太郎、村上一馬、徳田真樹、泉 俊輔、入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • アポモルフィンによるアミロイドβ42凝集抑制機構の解析
        花木瑞穂; 村上一馬; 片山寿美枝; 赤木謙一; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • Aplysiatoxin 単純化アナログ・10-Methyl-aplog-1のがん細胞増殖抑制に関わるPKCアイソザイムの同定
        花木祐輔; 四方雄貴; 菊森将之; 堀田夏紀; 井本正哉; 入江一浩
        2018年度日本農芸化学会大会(名城大学、名古屋市), Mar. 2018, Last author, Corresponding author
      • アプリシアトキシン単純化アナログのがん細胞増殖抑制活性
        Kazuhiro Irie
        先端モデル動物支援プラットフォーム 成果発表会2017(琵琶湖ホテル、大津市), Jan. 2018, Invited, Lead author, Corresponding author
      • 脳脊髄液中の毒性Aβコンホマーの測定
        冨所康志、石井一弘、玉岡 晃、入江一浩
        日本認知症学会学術集会(石川県立音楽堂、金沢市), Nov. 2017
      • 新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである
        鷲崎彩夏; 村田めぐみ; 関 洋平; Yin Pui Tang; 寒川裕之; 入江一浩; 明里宏文
        第31回日本エイズ学会学術集会・総会(中野サンプラザ、東京都中野区), Nov. 2017
      • 新規PKC activatorである10-methyl-aplog-1はHIV-1再活性化薬として有用である
        鷲崎彩夏; 村田めぐみ; 関 洋平; Yin Pui Tang; 寒川裕之; 入江一浩; 明里宏文
        第65回日本ウイルス学会学術集会(大阪国際会議場、大阪市), Oct. 2017
      • 神経細胞毒性を有する準安定なアミロイドβの2量体モデルの合成とイオンモビリティー質量分析法による構造解析
        入江一浩; 入江由美; 村上一馬; 花木瑞穂; 花木祐輔; 川瀬泰司; 廣瀬賢治; 徳田隆彦; 前田雅弘
        第35回メディシナルケミストリーシンポジウム(名古屋大学、名古屋市), Oct. 2017, Lead author, Corresponding author
      • Measurement of toxic Aβ conformer in cerebrospinal fluid obtained from the cases of AD dementia
        Tomidokoro, Y., Ishii, K., Irie, K., Tamaoka, A.
        XXIII World Congress of Neurology (International Conference Center Kyoto) (Kyoto, Japan), Sep. 2017
      • 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構
        村上一馬; 吉岡卓也; 井戸恭平; 花木瑞穂; 山口加乃子; 緑川諭弘; 谷脇慎治; 郡司祐樹; 赤木謙一; 川瀬泰司; 廣瀬賢治; 入江一浩
        第59回天然有機化合物討論会(わくわくホリデーホール、札幌市), Sep. 2017, Peer-reviewed, Last author, Corresponding author
      • A Novel PKC activator, 10-methyl-aplog-1, induces HIV-1 efficiently in combination with BET inhibitor JQ1
        Washizaki, A; Murata, M; Seki, Y; Tang, Y. P; Irie, K; Akari, H
        35th Annual Symposium on Nonhuman Primate Models for AIDS (Overture Center for the Arts) (Madison, USA), Aug. 2017
      • アミロイドβの毒性配座理論と抗体創製
        村上一馬; 入江一浩
        認知症研究を知る若手研究者の集まり2017(湯の宿木もれび、大津市), Jul. 2017
      • アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発
        泉尾直孝
        日本薬学会第137年会(仙台国際センター、仙台市), Mar. 2017, Invited
      • アミロイドβ42の35番目でジスルフィド架橋したダイマーの合成と活性評価
        村上一馬; 加藤春花; 花木瑞穂; 物部容子; 赤木謙一; 入江一浩
        2017年度日本農芸化学会大会(京都女子大学、京都市), Mar. 2017, Last author, Corresponding author
      • アミロイドβ40の毒性オリゴマーモデル
        入江由美; 村上一馬; 花木瑞穂; 花木祐輔; 鈴木天志; 物部容子; 高井朋代; 赤木謙一; 川瀬泰司; 廣瀬賢治; 入江一浩
        2017年度日本農芸化学会大会(京都女子大学、京都市), Mar. 2017, Last author, Corresponding author
      • 漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム
        吉岡卓也; 村上一馬; 花木瑞穂; 緑川諭弘; 谷脇慎治; 郡司祐樹; 川瀬泰司; 廣瀬賢治; 入江一浩
        2017年度日本農芸化学会大会(京都女子大学、京都市), Mar. 2017, Last author, Corresponding author
      • Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響
        花木祐輔; 菊森将之; 徳田春邦; 岡村睦美; 旦 慎吾; 柳田 亮; 入江一浩
        2017年度日本農芸化学会大会(京都女子大学、京都市), Mar. 2017, Last author, Corresponding author
      • 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性
        村上一馬; 入江一浩
        第35回日本認知症学会学術集会(東京国際フォーラム、東京都千代田区), Dec. 2016, Invited
      • ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害
        吉岡卓也; 村上一馬; 井戸恭平; 花木瑞穂; 山口加乃子; 緑川諭弘; 谷脇慎治; 郡司祐樹; 入江一浩
        第35回日本認知症学会学術集会(東京国際フォーラム、東京都千代田区), Dec. 2016, Last author, Corresponding author
      • アミロイドβ40の2量体モデルの合成と神経細胞毒性
        入江由美; 村上一馬; 鈴木天志; 花木瑞穂; 花木祐輔; 物部容子; 高井朋代; 赤木謙一; 入江一浩
        第35回日本認知症学会学術集会(東京国際フォーラム、東京都千代田区), Dec. 2016
      • アプリシアトキシンおよびジアシルグリセロールの受容体認識部位の構造活性相関研究
        芦田能基
        2016年日本化学会中国四国支部大会 香川大会(香川大学幸町北キャンパス、高松市), Nov. 2016
      • Structural optimization and mechanistic analysis of the anto-proliferative activity of aplog-1, a simplified analog of debromoaplysiatoxin
        Yusuke Hanaki
        58th Symposium on the chemistry of natural products, Sep. 2016, Peer-reviewed
      • Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer’s disease
        N. Izuo
        2016 Spring International Conference of the Korean Society for Gerontology (Hotel Laonzena, Convention Hall) (Daegu, Korea), Jun. 2016
      • Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する
        泉尾直孝
        日本基礎老化学会大会(伊勢原市民文化会館、伊勢原市), May 2016
      • クルクミンの機能性発現機構におけるタンパク質ストレス作用の関与
        村上明; 村上明; 村上明; 今林健登; 村川慧; VALENTINE Cindy; 中畑恵利奈; 大西康太; 入江一浩
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2016
      • Thapsigargin のC1ドメインに対する結合能と結合選択性の評価
        高橋知世
        2016年度日本農芸化学会大会(札幌コンベンションセンター、札幌市), Mar. 2016
      • 分子モデリングによるAplysiatoxinとプロテインキナーゼC C1ドメインとの結合様式の予測
        芦田能基
        2016年度日本農芸化学会大会(札幌コンベンションセンター、札幌市), Mar. 2016
      • チョウトウコウに含まれるウンカリン酸Cおよびその誘導体のアミロイドβ凝集阻害活性
        吉岡卓也
        2016年度日本農芸化学会大会(札幌コンベンションセンター、札幌市), Mar. 2016
      • 新規抗がん剤シード・10-Me-aplog-1のがん細胞増殖抑制機構
        花木祐輔
        2016年度日本農芸化学会大会(札幌コンベンションセンター、札幌市), Mar. 2016
      • アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用
        村上一馬
        2016年度日本農芸化学会大会(札幌コンベンションセンター、札幌市), Mar. 2016
      • Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition
        泉尾直孝
        第89回日本薬理学会年会(パシフィコ横浜、横浜市), Mar. 2016
      • 新規抗がん剤シード・aplog類のがん細胞増殖抑制機構の解析
        花木祐輔
        新学術領域研究「天然物ケミカルバイオロジー〜分子標的と活性制御〜」地区ミニシンポジウム(京都大学、京都市), Feb. 2016
      • Large-scale synthesis, anti-cancer activity in vivo, and mechanism of anti-proliferative activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as an anti-cancer lead
        Y. Hanaki
        The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takea Pharmaceutical Company, Ltd.) (Suita, Japan), Jan. 2016
      • Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease
        K. Murakami
        The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan), Jan. 2016
      • ハナショウガ成分zerumboneの新しい抗炎症機構
        五十嵐洋子; 大西康太; 入江一浩; 村上明
        日本香辛料研究会講演要旨集, 2016
      • 神経細胞内に蓄積したAβ42が細胞死を引き起こす機構
        奥 勇紀; 村上 一馬; 入江 一浩; 寶関 淳; 阪井 康能
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
      • Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する
        泉尾直孝
        第38回日本分子生物学会年会(神戸ポートアイランド、神戸市), Dec. 2015
      • Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare
        K. Irie
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015, Invited
      • Structure–activity studies on the PKC-recognition domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare
        Y. Ashida
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015
      • Isolation and ability to bind to protein kinase C of (20S)-bryostatin 19 from Japanese bryozoan: elucidation of the role of the side-chain at position 20
        R. C. Yanagita
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015
      • Synthesis and biological activities of the amide derivative of aplog-1
        Y. Hanaki
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015
      • Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.
        K. Murakami
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015, Invited
      • Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids
        M. Hanaki
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015
      • アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用
        村上一馬; 入江一浩
        第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会(京都大学原子炉実験所、熊取町), Nov. 2015
      • In vitro display evolution of cyclized peptidomimetics to a chemically synthesized amyloid beta protein dimer
        川上隆史
        第52回ペプチド討論会(平塚中央公民館、平塚市), Nov. 2015
      • アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用
        村上一馬; 花木瑞穂; 赤木謙一; 石井亮太郎; 徳田隆彦; 前田雅弘; 泉尾直孝; 清水孝彦; 入江一浩
        第34回日本認知症学会学術集会(リンクステーションホール青森), Oct. 2015, Last author, Corresponding author
      • Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する
        泉尾直孝
        第34回日本認知症学会学術集会(リンクステーションホール青森), Oct. 2015
      • SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析
        花木瑞穂; 村上一馬; 赤木謙一; 入江一浩
        2015年度日本農芸化学会中部・関西支部合同大会(富山県立大学), Sep. 2015, Last author, Corresponding author
      • 非カテコール型フラボノイドによるアミロイドβの凝集抑制機構
        花木瑞穂; 村上一馬; 赤木謙一; 入江一浩
        第57回天然有機化合物討論会(神奈川県民ホール), Sep. 2015, Peer-reviewed, Last author, Corresponding author
      • Aβ毒性コンホマーの選択的除去は老人班形成を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する
        N. Izuo
        第5回認知症研究を知る若手研究者の集まり2015(高崎市), Aug. 2015
      • アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用
        K. Murakami; K. Irie
        第47回若手ペプチド夏の勉強会、信州塩尻・天然温泉アスティかたおか(塩尻市), Aug. 2015, Invited
      • ハワイ産ラン藻Moorea producens由来の新規lyngbyatoxin A誘導体類の構造ならびに活性
        江偉娜 他
        第62回トキシンシンポジウム(志摩市), Jul. 2015
      • リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製
        宮前友策
        日本ケミカルバイオロジー学会第10回年会(仙台), Jun. 2015
      • Passive immunotherapy targeting to the “toxic conformer” of amyloid β ameliorates neurological symptom in Alzheimer’s disease model
        Naotaka Izuo
        第38回 日本基礎老化学会大会(パシフィコ横浜), Jun. 2015
      • Zerumboneの抗炎症作用におけるタンパク質ストレスの役割
        五十嵐洋子; 大西康太; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015
      • 神経細胞内に蓄積したAβ42による細胞毒性の発現機構
        奥勇紀; 村上一馬; 入江一浩; 寶関淳; 阪井康能
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015
      • リガンド結合ポケットの特性に基づく新規共有結合性PPARγアゴニストの創製
        宮前友策
        2015年度日本農芸化学会大会(岡山), Mar. 2015
      • 日本産フサコケムシからの新規bryostatin類の単離と活性
        村木謙介
        2015年度日本農芸化学会大会(岡山), Mar. 2015
      • AplysiatoxinのPKC C1ドメイン認識部位の構造活性相関研究
        芦田能基
        2015年度日本農芸化学会大会(岡山), Mar. 2015
      • 細胞増殖抑制能を有するアプリシアトキシン単純化アナログのアミド誘導体の合成と活性
        花木祐輔
        2015年度日本農芸化学会大会(岡山), Mar. 2015
      • アミロイドβ42ダイマーの合成と活性評価
        徳田真樹
        2015年度日本農芸化学会大会(岡山), Mar. 2015
      • Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity
        泉尾直孝
        第88回日本薬理学会年会(名古屋国際会議場), Mar. 2015
      • Cooperative activation of PPARγ by combination of irreversible antagonist and partial agonists: implication for novel activation mechanism based on covalent modification
        Yusaku Miyamae; Anna Ohtera; Kotaro Yoshida; Tohru Akita; Kazuhiro Maejima; Akira Kakizuka; Kazuhiro Irie; Seiji Masuda; Taiho Kambe; Masaya Nagao
        International Chemical Biology Society 3rd annual meeting, Nov. 2014, Peer-reviewed
      • 非カテコール型フラボノイドによるアミロイドβ42の凝集抑制機構
        佐藤瑞穂
        第33回日本認知症学会学術集会(横浜), Nov. 2014, Peer-reviewed
      • 非共有結合性リガンドの開発を目指した新規PPARγ活性化機構の解明
        宮前友策
        第56回天然有機化合物討論会(高知市), Oct. 2014, Peer-reviewed
      • ラン藻Moorea producensより単離した新規lyngbyatoxin A誘導体の構造および生物活性
        江偉娜 他
        第56回天然有機化合物討論会(高知市), Oct. 2014, Peer-reviewed
      • Structural insights into inhibitory ability of flavonoids for Aβ42 aggregation
        M. Sato
        XXVIIth International Confefence on Polyphenols (Nagoya, Japan), Sep. 2014, Peer-reviewed
      • 青じそ由来化合物DDC のAβ誘発神経毒性に対する保護作用
        岩崎真実; 泉安彦; 村上一馬; 入江一浩; 赤池昭紀; 久米利明
        次世代を担う創薬・医療薬理シンポジウム2014, Aug. 2014
      • Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla
        K. Murakami
        Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark), Jul. 2014, Peer-reviewed
      • Synthesis and biological activities of the Aβ40 dimer with toxic conformation
        K. Irie
        Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark), Jul. 2014, Peer-reviewed
      • 抗線維化物質テトランドリンによるオートファジー経路制御機構の解析
        西藤有希奈; 宮前友策; 仲井奈緒美; Han Junkyu; 礒田博子; 増田誠司; 神戸大朋; 入江一浩; 永尾雅哉
        日本ケミカルバイオロジー学会第9回年会, Jun. 2014, Peer-reviewed
      • 12-Epi-lyngbyatoxin A, a new toxic substance from the cyanobacteria Moorea producens
        Jiang, W
        The Asia-Pacific Section Congress of International Society of Toxicology (Changsha, China), Jun. 2014
      • Identification of the “toxic conformer” of amyloid β in Alzheimer’s disease
        泉尾直孝
        日本基礎老化学会大会(横浜), Jun. 2014
      • アプリシアトキシン単純化アナログ (Aplog-1) の抗がん剤シーズとしての構造最適化
        菊森将之; 柳田 亮; 中川 優; 蒲池弘明; 徳田春邦; 鈴木信孝; 入江一浩
        新学術領域研究・がん支援「化学療法基盤支援活動」第3回シンポジウム(名護市、万国津梁館), May 2014, Peer-reviewed, Last author, Corresponding author
      • 食品由来のファイトケミカルによるタンパク質変性作用の評価
        今林健登; 中畑恵利奈; 大西康太; 田中遼平; 五十嵐洋子; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014
      • バンウコンからのPPARγアンタゴニスト変換活性物質の単離と推定結合様式の解析
        宮前友策; 大寺杏奈; 吉田光多郎; 仲井奈緒美; 王健一; 秋田徹; 前嶋一宏; 増田誠司; 神戸大朋; 森直樹; 入江一浩; 永尾雅哉
        日本農芸化学会2014年度大会, Mar. 2014
      • Site-specific inhibitory mechanisms for amyloid β aggregation by catechol-type flavonoids
        M. Sato
        Institute for Chemical Research International Symposium 2014 (Kyoto, Japan), Mar. 2014
      • Debromoaplysiatoxinの4位不斉メチル基の生物活性おける役割
        菊森将之
        2014年度日本農芸化学会大会(東京), Mar. 2014
      • アミロイドβダイマーの合成と活性評価
        鈴木天志; 村上一馬; 佐藤瑞穂; 岩崎真実; 久米利明; 入江一浩
        2014年度日本農芸化学会大会(東京), Mar. 2014, Last author, Corresponding author
      • 非カテコール型フラボノイドによるアミロイドβ42凝集抑制機構
        佐藤瑞穂
        2014年度日本農芸化学会大会(東京), Mar. 2014
      • 伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質
        村上一馬
        2014年度日本農芸化学会大会(東京), Mar. 2014
      • Zerumboneの抗炎症作用機構の解析~タンパク質ストレス関与の可能性~
        五十嵐洋子; 大西康太; 入江一浩; 村上明
        日本フードファクター学会学術集会講演要旨集, 2014
      • 細胞タンパク質変性作用を介したcurcuminの機能性発現機構
        中畑恵利奈; VALENTINE Cindy; 大西康太; 入江一浩; 村上明
        日本香辛料研究会講演要旨集, 2014
      • 神経細胞内に蓄積したAβ42による細胞毒性の発症機構
        奥勇紀; 村上一馬; 入江一浩; 寳関淳; 阪井康能
        日本分子生物学会年会プログラム・要旨集(Web), 2014
      • A new lyngbyatoxin from the hawaiian cyanobacterium Moorea producens
        Weina Jiang; Wei Zhou; Hajime Uchida; Masayuki Kikumori; Kazuhiro Irie; Ryuichi Watanabe; Toshiyuki Suzuki; Bryan Sakamoto; Michiya Kamio; Hiroshi Nagai
        Marine Drugs, 2014
      • Induction of Oxidative stress by the "toxic conformer" is crucial for A beta 42
        Naotaka Izuo; Toshiaki Kume; Kazuma Murakami; Mizuho Sato; Kazuhiro Irie; Yasuhiko Izumi; Akinori Akaike; Koutaro Yokote; Takahiko Shimizu
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
      • 食品由来カフェオイルキナ酸の神経細胞保護効果
        繁森英幸; 宮前友策; 栗栖真奈美; 村上一馬; 入江一浩; Han Junkyu; 礒田博子
        日本機能性食品医用学会, Dec. 2013, Peer-reviewed
      • Aβ42誘発神経毒性には、「毒性コンホマー」による酸化ストレス誘導が重要である
        泉尾直孝
        第36回日本分子生物学会年会(神戸), Dec. 2013
      • 成体マウス海馬におけるAβのニューロン新生抑制作用
        久米利明; 岩尾歩美; 入江一浩; 泉安彦; 赤池昭紀
        第7回次世代を担う若手医療薬科学シンポジウム, Nov. 2013
      • 食品からのNrf2-ARE経路活性化物質の同定および薬効解析
        泉安彦; 松村敦子; 久米利明; 入江一浩; 赤池 昭紀
        第5回食品薬学シンポジウム, Nov. 2013
      • ポリフェノールによるアミロイドβ42の凝集抑制機構
        村上一馬
        第6回タンパク質の異常凝集とその防御・修復機構に関する研究会(京都大学原子炉実験所), Nov. 2013
      • カテコール型フラボノイド類のアミロイドβ凝集抑制機構
        佐藤瑞穂
        第32回日本認知症学会学術集会(松本), Nov. 2013, Peer-reviewed
      • アルツハイマー病患者iPS細胞由来神経系細胞におけるAβオリゴマーの細胞毒性
        中野 梨絵; 浅井 将; 近藤 孝之; 月田 香代子; 渡邊 かおり; 門谷 千恵; 村上 一馬; 入江 一浩; Klein William L; 森 啓; 丸山 啓; 朝田 隆; 城谷 圭朗; 井上 治久; 岩田 修永
        Dementia Japan, Oct. 2013
      • Aβおよびその変異体による成体マウス海馬ニューロン新生抑制作用
        久米利明; 岩尾歩美; 入江一浩; 泉安彦; 赤池昭紀
        第123回日本薬理学会近畿部会, Jul. 2013
      • 抗線維化物質テトランドリンによるマクロリポファジー制御
        宮前 友策; 西藤 有希奈; 仲井 奈緒美; 翁長 彰子; 韓 畯奎; 礒田 博子; 芦田 久; 神戸 大朋; 増田 誠司; 入江 一浩; 永尾 雅哉
        第3回植物生理科学シンポジウム, Jul. 2013
      • Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology
        Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T.
        Alzheimer's Association International Conference (AAIC) 2013 in Boston, USA, Jul. 2013
      • Specific inhibitory mechanisms for Aβ42 aggregation by flavonoids
        M. Sato
        Alzheimer's Association International Conference (AAIC) 2013 (Boston, USA), Jul. 2013
      • ニガハッカ由来不飽和脂肪酸のPPARγ及びGPR40に対するデュアルアゴニスト活性
        大寺杏奈; 宮前友策; 仲井奈緒美; 荒川武明; 平澤明; 河内敦; 川田清和; 韓畯奎; 礒田博子; Mohamed Neffati; 前嶋一宏; 秋田徹; 森直樹; 入江一浩; 神戸大朋; 増田誠司; 永尾雅哉
        新規素材探索研究会, Jun. 2013
      • Role of methyl groups on the spiroketal moiety of aplog-1, a simplified analogue of debromoaplysiatoxin with anti-proliferative activity
        M. Kikumori
        23rd French-Japanese Symposium of Medicinal and Fine Chemistry (Nagasaki, Japan), May 2013
      • 抗発がん性テルペノイドzerumboneによる異常タンパク質分解系の活性化
        大西康太; 石坂朱里; 河合慶親; 寺尾純二; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013
      • ニガハッカからのPPARγアゴニスト活性物質の探索
        大寺杏奈; 宮前友策; 仲井奈緒美; 荒川武明; 平澤明; 河内敦; 川田清和; 韓畯奎; 礒田博子; Mohamed Neffati; 前嶋一宏; 秋田徹; 森直樹; 入江一浩; 神戸大朋; 増田誠司; 永尾雅哉
        日本農芸化学会2013年度大会, Mar. 2013
      • 青ジソ抽出物からのNrf2-ARE経路活性化成分の単離および同定
        泉 安彦
        第85回日本薬理学会年会(京都), Mar. 2013
      • Debromoaplysiatoxin単純化アナログの10位メチル体の発がん促進活性
        菊森将之
        2013年度日本農芸化学会大会(仙台), Mar. 2013
      • Debromoaplysiatoxin単純化アナログの27位における構造活性相関
        花木祐輔
        2013年度日本農芸化学会大会(仙台), Mar. 2013
      • ビタミンCによるアルツハイマー病態緩和
        村上一馬
        2013年度日本農芸化学会大会(仙台), Mar. 2013
      • 自動酸化によるアポモルフィンのアミロイドβ凝集阻害機構の解析
        佐藤瑞穂
        2013年度日本農芸化学会大会(仙台), Mar. 2013
      • 細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する
        清水孝彦
        第35回日本分子生物学会年会(福岡), Dec. 2012
      • 干しいもに含まれるカフェオイルキナ酸のアルツハイマー症予防効果
        繁森英幸
        第23回日本化学会関東支部茨城地区研究交流会(日立), Nov. 2012
      • Solid-state NMR analysis of interaction sites of curcumin and amyloid β-protein fibrils
        Y. Masuda
        The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan), Nov. 2012, Peer-reviewed
      • Specific inhibitory mechanism of aggregation of 42-mer amyloid-β peptide by flavonoids
        M. Sato
        The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan), Nov. 2012, Peer-reviewed
      • Aβ42の”毒性コンホマー”形成による細胞内酸化ストレスの誘導
        泉尾直孝
        第31回日本認知症学会学術集会, Oct. 2012
      • アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割
        村上一馬
        第31回日本認知症学会学術集会, Oct. 2012
      • Aβ42 “毒性コンホマー”の形成は細胞内酸化ストレスを誘導する
        泉尾直孝
        次世代を担う創薬・医療薬理シンポジウム 2012(神戸), Sep. 2012
      • Debromoaplysiatoxin単純化アナログの10位メチル体の合成と細胞増殖抑制活性
        菊森将之
        2012年度日本農芸化学会関西支部大会(亀岡), Sep. 2012
      • 17 Specific Inhibitory Mechanism of Aβ42 Aggregation by Catechol-Type Flavonoids(Oral Presentation)
        Murakami Kazuma; Sato Mizuho; Ikubo Haruko; Uno Mayumi; Nakagawa Yu; Katayama Sumie; Akagi Ken-ichi; Masuda Yuichi; Takegoshi Kiyonori; Irie Kazuhiro
        Symposium on the Chemistry of Natural Products, symposium papers, Sep. 2012, Peer-reviewed
      • CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice
        K. Murakami
        Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada, Jul. 2012, Peer-reviewed
      • Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D23
        K. Irie
        Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada, Jul. 2012, Peer-reviewed
      • 寄生植物由来化合物のアミロイドβ凝集阻害活性に関する研究
        栗栖真奈美; 宮前友策; 木立恵利; 村上一馬; Han Junkyu; 礒田博子; 入江一浩; 繁森英幸
        新規素材探索研究会, Jun. 2012
      • 抗線維化物質テトランドリンの肝星細胞におけるマクロリポファジー制御
        宮前友策; 仲井奈緒美; 翁長彰子; 韓畯奎; 礒田博子; 芦田久; 神戸大朋; 増田誠司; 入江一浩; 永尾雅哉
        日本ケミカルバイオロジー学会第7回年会, Jun. 2012, Peer-reviewed
      • バンウコンからのPPARγアンタゴニスト変換活性物質の探索
        宮前友策; 吉田光多郎; 大寺杏奈; 仲井奈緒美; 王健一; 秋田徹; 前嶋一宏; 森直樹; 入江一浩; 神戸大朋; 増田誠司; 永尾雅哉
        新規素材探索研究会, Jun. 2012
      • Erratum: Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP (Bioorganic and Medicinal Chemistry (2011) 19 (4377-4385))
        Kawamura T; Matsubara K; Otaka H; Tashiro E; Shindo K; Yanagita R; Irie K; Imoto M
        Bioorganic and Medicinal Chemistry, 01 Apr. 2012
      • トマト成分lycopeneによる生体防御機構の活性化
        大倉伸哉; 大西康太; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012
      • アミロイド β誘発神経毒性における 22,23位でのターン構造の重要性
        泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一浩; 泉安彦; 赤池昭紀
        第 85回日本薬理学会年会, Mar. 2012
      • 抗線維化物質テトランドリンによる肝星細胞でのマクロリポファジー制御
        宮前友策; 仲井奈緒美; 翁長彰子; 韓畯奎; 礒田博子; 芦田久; 神戸大朋; 入江一浩; 永尾雅哉
        日本農芸化学会2012年度大会, Mar. 2012
      • Streptomyces blastmyceticus由来 (-)-indolactam V生合成遺伝子の放線菌における発現
        奥田治子
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない
        清水孝彦
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • 細胞質酸化ストレスによるアミロイド β オリゴマー形成能および記憶異常の促進
        村上一馬
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • 酸化型タキシフォリンによるアミロイド β の凝集抑制機構
        佐藤瑞穂
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • ヤセウツボ (Orobanche minor) 由来化合物のアミロイドβ凝集阻害活性に関する研究
        栗栖真奈美
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • イソプレニル修飾酵素ComQのイソプレノイド選択性に関わるアミノ酸残基の同定
        山崎梨沙
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • ゲラニルトリプトファンの生合成に関する研究
        石原紋子
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • 木田チリメンシソから単離したガラクトグリセロ脂質は食細胞においてO2-およびNOの産生を阻害する
        高橋正和
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • 抗腫瘍性Aplysiatoxin単純化アナログの側鎖の構造活性相関を目的とした合成経路の確立
        朱 裕姫
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • 日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価
        植野紗代
        2012年度日本農芸化学会大会(京都), Mar. 2012
      • 固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発
        村上 一馬; 増田 裕一; 入江 一浩
        遺伝子医学MOOK, 2012, Peer-reviewed, Invited
      • Activation of protein quality control systems induced by food chemicals
        大西 康太; 中畑 恵利奈; 石坂 朱里; 河合 慶親; 寺尾 純二; 木岡 紀幸; 入江 一浩; 村上 明
        2012年度日本農芸化学会, 2012
      • Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid beta
        Naotaka Izuo; Toshiaki Kume; Mizuho Sato; Kazuma Murakami; Kazuhiro Irie; Yasuhiko Izumi; Akinori Akaike
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012
      • Insulin receptor mutation results in insulin resistance and hyper insulinemia but does not worsen Alzheimer's-like phenotypes in mice
        Yusuke Ozawa
        The 34th Annual Meeting of the Molecular Biology Society of Japan (Yokohama), Dec. 2011
      • Zerumbone increases thermoresistance in mouse hepatocytes and nematodes.
        Erina Nakahata; Kohta Ohnishi; Kazuhiro Irie; Shinya Matsumoto; Akira Murakami
        The 5th International Conference on Food Factors, Nov. 2011, Peer-reviewed
      • Effects of food phytochemicals on the expression of heat shock proteins in Hepa1c1c7 cells.
        Shinya Ohkura; Kohta Ohnishi; Kazuhiro Irie; Akira Murakami
        The 5th International Conference on Food Factors, Nov. 2011, Peer-reviewed
      • Both specific and non-specific protein modifications by zerumbone may contribute to its bioactivities.
        Kohta Ohnishi; Akari Ishisaka; Taiki Mori; Yoshichika Kawai; Junji Terao; Takeshi Ishii; Tsutomu Nakayama; Noriyuki Kioka; Kazuhiro Irie; Akira Murakami
        The 5th International Conference on Food Factors, Nov. 2011, Peer-reviewed
      • Silymarin attenuated the amyloid β deposition and behavioral abnormalities in a mouse model of Alzheimer’s disease
        Takahiko Shimizu
        41st Annual Meeting of Society for Neuroscience (Washington DC, USA), Nov. 2011
      • Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not worsen Alzheimer’s-like phenotypes in mice
        Takuji Shirasawa
        41st Annual Meeting of Society for Neuroscience (Washington DC, USA), Nov. 2011
      • Nrf2-ARE経路活性化作用を有する食品由来成分の探索
        松村敦子
        第120回日本薬理学会近畿部会(京都), Nov. 2011
      • 大阪変異によるアミロイドβの毒性コンホマー形成能の増大
        村上一馬
        第30回日本認知症学会学術集会(東京), Nov. 2011
      • 抗酸化ストレスに着目したアルツハイマー病予防の可能性
        村上一馬
        原子炉実験所専門研究会(熊取), Nov. 2011
      • 気孔形成を調節するペプチドホルモンの機能解析
        平林智美
        第46回植物化学調節学会(宇都宮), Nov. 2011
      • タキシフォリンによるアミロイドβの凝集抑制機構
        佐藤瑞穂
        2011年度日本農芸化学会関西・中部支部合同大会(京都), Oct. 2011
      • Antibody against toxic conformer of Alzheimer β.
        Murakami, K; Horikoshi-Sakuraba, Y; Kinoshita, N; Shirasawa, T; Shimizu, T; Irie, K
        22nd French-Japanese Symposium on Medicinal and Fine Chemistry, Rouen, France, Sep. 2011, Peer-reviewed
      • カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構
        宮前友策
        第53回天然有機化合物討論会(大阪), Sep. 2011, Peer-reviewed
      • アミロイドβ凝集体におけるクルクミンの相互作用部位の固体NMRによる解析
        増田裕一
        化学系学協会東北大会(仙台), Sep. 2011
      • Inhibitory mechanism of amyloid β aggregation by flavonoids
        Mizuho Sato
        27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia), Jul. 2011
      • E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ42
        Kazuma Murakami
        27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia), Jul. 2011
      • 変異体を用いたAβ誘発神経毒性におけるターン構造の重要性の検討
        泉尾直孝、久米利明、佐藤瑞穂、村上一馬、入江一浩、泉 安彦、赤池昭紀
        第119回日本薬理学会近畿部会(名古屋), Jul. 2011
      • Keap1‐Nrf2システムを介した求電子性テルペノイドzerumboneの生体防御機構活性化メカニズム
        大西康太; 中畑恵利奈; 入江一浩; 村上明
        日本酸化ストレス学会学術集会プログラム・抄録集, 27 Jun. 2011
      • 食品成分の分子シャペロン誘導作用とその分子機構の解明
        大倉伸哉; 大西康太; 中畑恵利奈; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集, 05 Mar. 2011
      • 抗炎症性テルペノイドzerumboneの生理活性発現機構
        大西康太; 大倉伸哉; 中畑恵利奈; 森大気; 石井剛志; 中山勉; 石坂朱里; 河合慶親; 寺尾純二; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集, 05 Mar. 2011
      • Zerumboneによる生体防御強化作用の解明
        中畑恵利奈; 大西康太; 大倉伸哉; 入江一浩; 松本晋也; 村上明
        日本農芸化学会大会講演要旨集, 05 Mar. 2011
      • ナツメに含まれるNO産生抑制成分の単離・同定と作用機序解析
        杉山友太
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • アミロイドβ凝集阻害物質Taxifolinの13C標識化
        佐藤瑞穂、村上一馬、井久保遥子、入江一浩
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • アミロイドβのGlu22欠損による毒性コンホマー形成能の促進
        村上一馬
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • 抗腫瘍性PKC活性化剤Aplog-1の生物活性におけるフェノール性水酸基の役割
        柳田 亮 他
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • アルツハイマー病モデルマウスに対するsilymarinの予防効果
        清水孝彦、村田 央、村上一馬、小澤裕介、木下憲明、入江一浩、白澤卓二
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • ホウレンソウに含まれるNO産生抑制物質
        中村志織、川畑球一、入江一浩、高橋正和、大東 肇
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • アミロイド β オリゴマーの固体NMRによる立体構造解析
        土井崇嗣
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • Aplysiatoxin単純化アナログの4位メチル体の各種生物活性
        菊森将之
        2011年度日本農芸化学会大会(京都), Mar. 2011
      • The mechanism of suppression of amyloid β-induced neurotoxicity by polyphenols in food
        入江 一浩
        食生活科学・文化及び環境に関する研究助成研究紀要, 2011
      • ハナショウガ含有テルペノイドzerumboneの標的分子~Keap1との共有結合を介した生体防御機構活性化メカニズム~
        大西康太; 入江一浩; 村上明
        日本香辛料研究会講演要旨集, 2011
      • Zerumbone is covalently bound to the key proteins involved in inflammatory and self-defense mechanisms.
        Kohta Ohnishi; Taiki Mori; Takeshi Ishii; Tsutomu Nakayama; Akari Ishisaka; Yoshichika Kawai; Junji Terao; Noriyuki Kioka; Kazuhiro Irie; Akira Murakami
        The International Chemical Congress of Pacific Basin Societies, Dec. 2010, Peer-reviewed
      • Analysis of interaction sites of curcumin with the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR
        Yuichi Masuda
        2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA), Dec. 2010
      • Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide
        Kazuma Murakami
        2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA), Dec. 2010, Peer-reviewed
      • Screening for activators of protein kinase C using its C1 domain peptide: identification and biological activities of bryostatin 10 from Japanese bryozoan
        Ryo C. Yanagita
        2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA), Dec. 2010, Peer-reviewed
      • Synthesis and biological profile of simple analogues of tumor-promoting aplysiatoxin as unique leads for anti-cancer drugs
        Kazuhiro Irie
        2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA), Dec. 2010, Peer-reviewed
      • Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by cell free system
        Fumitada Tsuji
        2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA), Dec. 2010, Peer-reviewed
      • SilymarinによるADモデルマウスの行動異常及びAβ オリゴマー形成の改善.
        村上一馬; 村田 央; 小澤裕介; 木下憲明; 入江一浩; 白澤卓二; 清水孝彦
        日本農芸化学会2010年度関西支部大会, 大阪, Oct. 2010, Peer-reviewed
      • アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製
        村上一馬; 堀越(櫻庭)優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩
        第52回天然有機化合物討論会(静岡)[討論会奨励賞受賞], Sep. 2010, Peer-reviewed, Last author, Corresponding author
      • 求電子性テルペノイドzerumboneの共有結合性標的分子
        大西康太; 石坂朱里; 河合慶親; 寺尾純二; 森大気; 石井剛志; 中山勉; 入江一浩; 村上明
        日本農芸化学会大会講演要旨集, 05 Mar. 2010
      • Polyphenols as Potential Preventive Agents for Alzheimer's Disease
        Yuichi Masuda; Kazuhiro Irie
        FOODS & FOOD INGREDIENTS JOURNAL OF JAPAN,San-Ei Gen F.F.I., Inc., 2010
      • アミロイドβプロトフィブリルの固体NMRによる立体構造解析
        土井崇嗣
        第49回NMR討論会(東京), 2010
      • 抗腫瘍性Aplysiatoxin誘導体の18位ヒドロキシル基の生物活性に与える影響
        柳田 亮; 蒲池弘明; 中川 優; 田中啓介; 徳田春邦; 入江一浩
        第45回天然物化学談話会(蒲郡), 2010, Last author, Corresponding author
      • 抗腫瘍性aplysiatoxin誘導体の4位メチル体の合成と生物活性
        菊森将之
        2010年度日本農芸化学会関西支部大会(奈良), 2010
      • アミロイドβの毒性ターン構造特異的抗体
        村上一馬
        第29回日本認知症学会学術集会(名古屋), 2010
      • Analysis of binding sites of curcumin in the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR
        Yuichi Masuda
        The 51st Experimental Nuclear Magnetic Resonance Conference (Florida, USA), 2010
      • Identification of Toxic Conformation in Aβ42 Aggregates Using Solid-state NMR
        MASUDA Yuichi; UEMURA Satoko; OHASHI Ryutaro; NAKANISHI Azusa; TAKEGOSHI K.; IRIE Kazuhiro
        Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009
      • 発がんプロモーター・アプリシアトキシンの骨格を利用した新規抗腫瘍性PKC活性化剤の開発
        中川優; 中川優; 柳田亮; 濱田直子; 永井宏史; 入江一浩
        日本農芸化学会大会講演要旨集, 2009
      • Silymarin inhibits fibril formation and neurotoxicity of amyloid β peptide
        Nakaba Murata
        第32回日本分子生物学会年会(横浜), 2009
      • アプリシアトキシンの骨格を有する抗腫瘍性PKC活性化剤のアナログ合成
        中川 優 他
        第57回有機合成化学協会関東支部シンポシウム(東京), 2009
      • 抗腫瘍性アプリシアトキシン誘導体の作用機構の解析
        柳田 亮 他
        第44回天然物化学談話会(つくば), 2009
      • 抗腫瘍性PKC活性化剤Aplog-1の生物活性における芳香環部分の置換基効果
        田中啓介
        2010年度日本農芸化学会大会(東京), 2009
      • Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein
        Kazuma Murakami
        39th Annual Meeting of Society for Neuroscience (Chicago, USA), 2009
      • Structure-activity relationship study of an antineoplastic protein kinase C activator having a skeleton of tumor-promoting aplysiatoxin
        Ryo C. Yanagita
        The 11th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan), 2009
      • アミロイドβの毒性コンホマーを標的とした立体構造特異的抗体
        村上一馬; 堀越(櫻庭)優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩
        2010年度日本農芸化学会大会(東京)[トピックス賞], 2009, Last author, Corresponding author
      • 抗腫瘍性aplysiatoxinアナログ・Aplog-1の12-ジメチル体の合成と生物活性
        中川 優; 柳田 亮; 高橋英之; 齋藤尚亮; 永井宏史; 入江一浩
        2010年度日本農芸化学会大会(東京), 2009, Last author, Corresponding author
      • 植物の気孔形成を誘導するペプチド性因子の構造と生理活性
        近藤竜彦
        2010年度日本農芸化学会大会(東京), 2009
      • Aβ42凝集体におけるクルクミン結合部位の固体NMRによる解析
        増田裕一
        2010年度日本農芸化学会大会(東京), 2009
      • 海洋動物に含まれる PKC 活性化剤の探索および活性評価
        柳田 亮 他
        2010年度日本農芸化学会大会(東京), 2009
      • 1Ip10 Characterization of tcnB and tcnC in a gene cluster involved in the teleocidin biosynthesis in Streptomyces blastmyceticus
        FURUKAWA Hirofumi; TANI Syuji; SUMITANI Jyunichi; KAWAGUTI Takashi; HAYASHI Hideo; IRIE Kazuhiro
        日本生物工学会大会講演要旨集, 2008
      • Aβ42凝集体のC末端における分子内β-シート構造の固体NMRによる検証
        増田裕一
        2009年度日本農芸化学会大会(博多), 2008
      • 酵素反応系を利用したComXRO-E-2フェロモンのゲラニル修飾の検出
        辻 史忠、倉田景子、小林 耕、杉本卓弥、増田裕一、入江 一浩、坂神 洋次
        2009年度日本農芸化学会大会(博多), 2008
      • βアミロイド凝集体のC末端における分子内βシート構造の固体NMRによる検証
        増田裕一
        第43回天然物化学談話会(大阪), 2008
      • 天然発がんプロモーターの骨格を利用した抗がん剤bryostatin等価体の開発
        中川 優; 蒲地弘明; 柳田 亮; 濱田直子; 高橋英之; 齋藤尚亮; 入江一浩
        第50回天然有機化合物討論会(福岡), 2008, Peer-reviewed, Last author, Corresponding author
      • アミロイド β ペプチド (Aβ42) の病的コンホメーションの提唱
        村上一馬
        日本基礎老化学会第31回大会(松本), 2008
      • βアミロイド凝集体に存在する毒性コンホメーションの同定
        増田裕一
        第27回日本認知症学会集会(前橋), 2008
      • Streptomyces blastmyceticum由来teleocidin生合成遺伝子群に存在するtcnB、TcnCの機能に関する研究
        古川博史; 谷 修治; 炭谷順一; 入江一浩; 林 英雄; 川口 剛司
        2009年度日本農芸化学会大会(博多), 2008
      • 酸化型タキシフォリンのアミロイドβ凝集阻害活性
        宇野真弓
        2009年度日本農芸化学会大会(博多), 2008
      • アミロイド β のAsp23における異性化あるいはラセミ化が凝集能および神経細胞毒性に及ぼす影響
        村上一馬
        2009年度日本農芸化学会大会(博多), 2008
      • Isomerization and/or racemization at Asp23 of Aβ42 do not enhance its aggregation, neurotoxicity, and radical productivity in vitro
        Kazuma Murakami
        38th Annual Meeting of Society for Neuroscience (Washington DC, USA), 2008
      • βアミロイドの毒性コンホメーションの同定
        増田裕一
        第45回ペプチド討論会(東京), 2008, Peer-reviewed
      • β アミロイドの毒性コンホメーションのESRならびに固体NMRによる検証
        入江一浩
        第27回日本認知症学会集会(前橋), 2008
      • Streptomyces blastmyceticus 由来 teleocidin 生合成遺伝子群に存在する tcnBおよび tcnC の機能
        古川博史
        第60回日本生物工学会大会(仙台), 2008
      • Spinocerebellar ataxia type 14-associated mutations in protein kinase Cgamma cause its aberrant self-association and cytotoxic aggregate formation
        H. Takahashi, N. Adachi, T. Sugimoto, K. Irie, T. Seki, N. Sakai, N. Saito
        Keystone Symposia on Neurodegenerative Diseases: New Molecular Mechanisms (Colorado, USA), 2008
      • アミロイドβペプチドのターン構造形成とアスパラギン酸残基修飾
        清水孝彦; 村上一馬; 宇野真弓; 入江一浩; 白澤卓二
        第80回日本生化学会大会ワークショップ, Dec. 2007, Peer-reviewed
      • Distance analysis between Tyr-10 and Met-35 in amyloid β using site-directed spin labeling ESR: implications for the stronger neurotoxicity of Aβ42 than Aβ40.
        Murakami, K; Hara, H; Irie, K
        37th Annual Meeting of Society for Neuroscience, San Diego, CA, USA, Nov. 2007, Peer-reviewed
      • 固体NMRならびにESRによるアミロイド β (Aβ42) の毒性コンホメーションの解析.
        入江一浩; 増田裕一; 村上一馬; 上村諭子; 原 英之; 大橋竜太郎; 中西 梓; 竹腰清乃理
        第 49回天然有機化合物討論会, 北海道, Sep. 2007, Peer-reviewed
      • ‘Malignant’ conformation of Alzheimer’s β peptides (Aβ42) through radical formation.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        International Conference of 43rd Japanese Peptide Symposium, Yokohama, Japan, Nov. 2006, Peer-reviewed
      • Elucidation of the ‘malignant’ conformation of β-amyloid with Italian mutation (E22K-Aβ42) using solid-state NMR.
        Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; Takegoshi, K
        ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan, Jul. 2006, Peer-reviewed
      • Formation and stabilization mechanism of the β-amyloid radical.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Jul. 2006, Peer-reviewed
      • Application of dipolar-assisted rotational resonance (DARR) to β-amyloid.
        Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; ○Takegoshi, K
        The 2005 International Chemical Congress of Pacific Basin Societies, Honolulu, USA, Dec. 2005, Peer-reviewed
      • Elucidation of the ‘malignant’ conformation of β-amyloid with Italian mutation (E22K-Aβ42) using solid-state NMR: implications for the pathogenesis of cerebral amyloid angiopathy and Alzheimer’s disease.
        Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; Takegoshi, K; Shimizu, T; Shirasawa, T
        35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed
      • Alzheimer’s 42-mer β peptide-specific mechanism of neurotoxicity through radical formation.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed
      • β アミロイドの新しい凝集モデルに基づく神経細胞毒性発現機構.
        村上一馬; 入江一浩; 森本 晃; 増田裕一; 大東 肇; 永尾雅哉; 清水孝彦; 白澤卓二
        第 47回天然有機化合物討論会, 徳島, Oct. 2005, Peer-reviewed
      • Structural analysis of amyloid β.
        Ohashi, R; Takegoshi, K; Terao, T; Masuda, Y; Murakami, K; Irie, K
        XXI International Conference on Magnetic Resonance in Biological Systems, (Hyderabad, Andhra Pradesh, India),, Jan. 2005
      • New aggregation model of amyloid β by the systematic proline replacement.
        Murakami, K; Irie, K; Morimoto, A; Masuda, Y; Ohigashi, H; Nagao, M; Fukuda, H; Shimizu, T; Shirasawa, T
        1st Asia-Pacific International Peptide Symposium, 41st Japanese Peptide Symposium, Fukuoka, Japan, Nov. 2004, Peer-reviewed
      • PKC CI ドメインの化学合成と質量分析法による機能解析
        入江 一浩
        日本農芸化学会誌, 05 Mar. 2001
      • Selective Binding of Tumor Promoters to the Novel PKC C1B Domains
        IRIE Kazuhiro; NAKAHARA Akifumi; NAKAGAWA Yu; OHIGASHI Hajime; SHINDO Mayumi; FUKUDA Hiroyuki; KONISHI Hiroaki; KIKKAWA Ushio
        Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001
      • Synthesis and Phorbol Ester Binding of the Zinc-finger Like Sequences of All Protein Kinase C Isozymes
        IRIE Kazuhiro; OIE Kentaro; NAKAHARA Akifumi; YANAI Yoshiaki; OHIGASHI Hajime; FUKUDA Hiroyuki; WENDER Paul A.
        Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Oct. 1998
      • Synthesis and Characterization of Model Peptides Incorporating the Phorbol Ester-binding Domain of Protein Kinase C
        IRIE Kazuhiro; YANAI Yoshiaki; OHIGASHI Hajime; WENDER Paul A.
        Peptide chemistry : proceedings of the ... Symposium on Peptide Chemistry, 01 Oct. 1996
      • 新規光反応性フォルポールエステルを用いたプロテインキナーゼC調節領域の光アフィニティーラベリング : 有機化学・天然物化学
        入江 一浩; 石居 尊司; 柳井 嘉明; 大東 肇; Wender Paul A.; Miller Benjamin L.
        日本農藝化學會誌, 05 Mar. 1996
      • フォルボールエステルのジアジリン誘導体の合成と特性 : 有機化学・天然物化学
        入江 一浩; 尾家 健太郎; 柳井 嘉明; 大東 肇; Wender Paul A.
        日本農藝化學會誌, 05 Mar. 1996
      • マウス皮膚PKC_ηの調節領域モデルペプチドの合成とその生化学的特性 : 有機化学・天然物化学
        柳井 嘉明; 入江 一浩; 大東 肇; Wender Paul A.; Miller Benjamin L.
        日本農藝化學會誌, 05 Mar. 1996
      • 微生物転換を用いた6位置換インドラクタムの合成研究 : 有機化学,天然物化学
        入江 一浩; 井口 真弥; 織田 恒幸; 鈴木 陽子; 大東 肇; 小清水 弘一; 林 英雄; 荒井 基夫
        日本農藝化學會誌, 05 Jul. 1995
      • 発癌プロモーター・インドラクタムの活性コンフォメーション : 有機化学,天然物化学
        入江 一浩; 小泉 文人; 岩田 依子; 石居 尊司; 柳井 嘉明; 中村 宜督; 大東 肇; Wender Paul A.
        日本農藝化學會誌, 05 Jul. 1995
      • 43 SYNTHESIS OF NEW INDOLACTAM ANALOGUES BY MICROBIAL CONVERSION AND THEIR IN VITRO BIOLOGICAL ACTIVITIES RELATED TO TUMOR PROMOTION
        Irie K; Kajiyama S; Okuno S; Koshimizu K; Nishino H; Iwashima A; Hayashi H; Arai M
        Symposium on the Chemistry of Natural Products, symposium papers, 1991
      • 41 STUDIES ON THE BIOSYNTHESIS OF INDOLE ALKALOID TUMOR PROMOTER TELEOCIDIN
        Irie K; Kajiyama S; Funaki A; Koshimizu K; Hayashi H; Arai M
        天然有機化合物討論会講演要旨集, 17 Sep. 1989
      • 蛍光標識発癌プロモーターの開発(有機化学・天然物化学-生理活性物質(動物・その他)-)
        入江 一浩; 小清水 弘一; 徳田 春邦; 西野 輔翼; 岩島 昭夫
        日本農藝化學會誌, 15 Mar. 1988
      • 新規テレオシジン代謝産物の構造と生理活性(有機化学・天然物化学-生理活性物質(動物・その他)-)
        舟木 敦; 入江 一浩; 萩原 宣行; 小清水 弘一; 徳田 春邦; 林 英雄; 荒井 基夫
        日本農藝化學會誌, 15 Mar. 1988
      • C-3 新規インドールアルカロイドblastmycetinAの構造と生理活性(日本農芸化学会関西支部大会報告)
        入江 一浩; 舟木 敦; 萩原 宣行; 徳田 春邦; 林 英雄; 荒井 基夫; 小清水 弘一
        日本農藝化學會誌, Dec. 1986

      Presentations

      • アミロイドβの毒性配座を標的とした立体構造特異抗体の開発とAD診断
        入江一浩
        第11回日本認知症予防学会学術集会(福岡国際会議場、福岡市), 24 Sep. 2022, Invited
      • アミロイドβの毒性配座を基盤としたアルツハイマー病の早期診断法の開発
        入江一浩
        Visionary農芸化学100シンポジウム(京都大学 益川ホール), 09 Sep. 2022, Invited
      • 天然PKCリガンドによる化学コミュニケーションの統合的理解と医薬品シーズの開発
        入江一浩
        新学術領域研究(化学コミュニ)第10回公開シンポジウム(藤多記念ホール、京都大学、京都市), 09 Jul. 2022, Invited
      • Development of monoclonal antibodies with specificity for a toxic conformer of amyloid beta and its application toward the diagnosis of Alzheimer’s disease
        Kazuhiro Irie
        Invited seminar at Institute of Biotechnology, National Taiwan University (online), 23 Nov. 2021, Invited
      • 新規PKCリガンドの開発とHIVのShock & Kill療法への応用
        IRIE Kazuhiro
        新学術領域研究(化学コミュニ)第6回公開シンポジウム(慶応義塾大学、横浜市), 09 Dec. 2019, Invited
      • アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略
        入江一浩
        日本農芸化学会東北支部第154回大会(弘前大学、弘前市), 09 Nov. 2019, Invited
      • アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略
        IRIE Kazuhiro
        日本農芸化学会 関西・中部支部 2019年度合同神戸大会(神戸大学、神戸市), 21 Sep. 2019, Invited
      • アミロイドβタンパク質とはーアルツハイマー病研究の最前線
        IRIE Kazuhiro
        サイエンスカフェ伊丹(伊丹市立生涯学習センター), 01 Jun. 2019, Invited
      • 日本農芸化学会賞受賞講演「アミロイドβの毒性配座理論を基盤としたアルツハイマー病の予防戦略」
        入江一浩
        2019年度日本農芸化学会大会(東京農大、東京), 25 Mar. 2019, 公益社団法人 日本農芸化学会, Invited
      • アミロイドβの毒性を示す立体構造の同定とアルツハイマー病診断への応用
        IRIE Kazuhiro
        第125回 支援センターセミナー(滋賀医科大学), 15 May 2018, 実験実習支援センター、神経難病研究センター, Invited
      • Development of monoclonal antibody with specificity for a toxic conformer of amyloid β and its application toward the Alzheimer’s disease diagnosis and therapeutics
        Kazuhiro Irie
        Seminar in The Florey Institute, The University of Melbourne, Australia, 20 Feb. 2018, Invited
      • アプリシアトキシン単純化アナログ・10-Me-Aplog-1の構造最適化とがん細胞増殖抑制に関わるPKCアイソザイムの同定
        Kazuhiro Irie
        新学術領域研究「化学コミュニケーションのフロンティア」第2回公開シンポジウム(京都大学益川ホール、京都市), 02 Feb. 2018, 新学術領域研究「化学コミュニケーションのフロンティア」総括班, Invited
      • アミロイドβの毒性2量体モデルの合成とイオンモビリティー質量分析法による構造解析
        Kazuhiro Irie
        京都大学学際融合教育研究推進センター・生理化学研究ユニット第7回公開シンポジウム(京都大学益川ホール、京都市), 22 Dec. 2017, 京都大学学際融合教育研究推進センター, Invited
      • 化学的手法に基づくアルツハイマー病の新しい予防戦略
        IRIE Kazuhiro
        グローバルサイエンスキャンパス京都大学(ELCAS2017)基盤コース, 07 Oct. 2017, 京都大学 学際融合教育研究推進センター 高大接続科学教育ユニット, Invited
      • Measurements of toxic oligomers of amyloid β by ion mobility–mass spectrometry
        IRIE Kazuhiro
        第65回質量分析総合討論会, 18 May 2017, The Mass Spectrometry Society of Japan, Invited
      • 化学的手法に基づくアルツハイマー病の新しい予防戦略
        IRIE Kazuhiro
        グローバルサイエンスキャンパス京都大学(ELCAS2016)基盤コース, 01 Oct. 2016, 京都大学 学際融合教育研究推進センター 高大接続科学教育ユニット, Invited
      • 抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析
        IRIE Kazuhiro
        新学術領域研究「天然物ケミカルバイオロジー」研究成果報告シンポジウム(慶應義塾大学日吉キャンパス、横浜市), 01 Jul. 2016, 新学術領域研究「天然物ケミカルバイオロジー」総括班, Invited
      • アプリシアトキシンの構造単純化による抗がん剤シーズの開発研究
        IRIE Kazuhiro
        第33回メディシナルケミストリーシンポジウム, 26 Nov. 2015, 日本薬学会・医薬化学部会, Invited
      • 化学的手法に基づくアルツハイマー病の新しい予防戦略
        IRIE Kazuhiro
        グローバルサイエンスキャンパス京都大学(ELCAS 2015)基盤コース, 17 Oct. 2015, 京都大学 学際融合教育研究推進センター 高大接続科学教育ユニット, Invited
      • 天然のプロテインキナーゼCリガンドの単純化による抗がん剤シーズの開発研究
        IRIE Kazuhiro
        の開発研究 日本農芸化学会2015年度中四国・西日本支部合同大会(愛媛大学農学部・樽味キャンパス), 17 Sep. 2015, 日本農芸化学会中四国・西日本支部, Invited
      • Inhibitory mechanism for amyloid beta42 aggregation by flavonoids
        Kazuhiro Irie
        Kyoto-Bordeaux Symposium 2015, 22 May 2015, Kyoto University and University of Bordeaux, Invited
      • 化学を武器にアルツハイマー病に挑む
        入江一浩
        関西大倉高校出前講義(高槻市), 10 Nov. 2014, Invited
      • 抗がん剤開発を指向した新規プロテインキナーゼCリガンドの創製
        Kazuhiro Irie
        京都大学学際融合教育研究推進センター・生理化学研究ユニット・第4回シンポジウム, 24 Jun. 2014, 生理化学研究ユニット, Invited
      • Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin
        Kazuhiro Irie
        International Symposium on Natural Products Chemistry and Chemical Biology, 26 Nov. 2013, JSPS, Asian CORE Program, Invited
      • ポリフェノールによるアルツハイマー病予防の可能性
        入江一浩
        数理分子セミナー, 17 May 2013, 広島大学理学研究科, Invited
      • ポリフェノールによるアミロイドβ の凝集抑制機構
        入江一浩
        2013年度日本農芸化学会大会, 27 Mar. 2013, 日本農芸化学会, Invited
      • アミロイドβタンパクの毒性ターン構造の同定とその構造特異抗体の開発
        入江一浩
        第15回アグリバイオセミナー, 22 Nov. 2012, 近畿大学農学部, Invited
      • Structure-activity studies on a simplified analog of debromoaplysiatoxin with anti-proliferative activity
        Kazuhiro Irie
        The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, 31 Oct. 2012, Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY, Invited
      • ポリフェノールによるアミロイドβの凝集阻害機構
        入江一浩
        第31回日本認知症学会学術集会, 28 Oct. 2012, 日本認知症学会, Invited
      • プロテインキナーゼCを標的とした新規抗がん剤シーズ
        入江一浩
        京都大学新技術説明会, 24 Aug. 2012, 京都大学・科学技術振興機構, Invited
      • 天然発がんプロモーターの骨格を利用した新規抗がん剤リードの開発
        入江一浩
        2012年度大会シンポジウム, 25 Mar. 2012, 日本農芸化学会, Invited
      • 抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析
        入江一浩
        新学術領域研究「天然物ケミカルバイオロジー」第一回公開シンポジウム, 10 Jan. 2012, 新学術領域研究「天然物ケミカルバイオロジー」総括班, Invited
      • 発がんプロモーターの骨格を利用した新規ツール分子と抗がん剤シーズの開発
        入江一浩
        日本農芸化学会関西支部例会(第472回講演会), 10 Dec. 2011, 日本農芸化学会関西支部, Invited
      • Development of new molecular probes and therapeutic seeds having skeletons of naturally-occurring tumor promoters
        Kazuhiro Irie
        22nd French-Japanese Symposium of Medicinal and Fine Chemistry (Rouen, France), 13 Sep. 2011, Invited
      • Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 1
        Kazuhiro Irie
        27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia), 11 Jul. 2011, Invited
      • アミロイドβの毒性ターン構造を認識する抗体の開発
        入江一浩
        第52回日本神経学会学術大会(名古屋), 19 May 2011, 日本神経学会, Invited
      • アミロイドβタンパクの毒性コンホメーションの同定と薬剤開発
        入江一浩
        香川大学農学部第2回公開シンポジウム「生命を化学の視点から探究する」, 2010, Invited
      • Development of anticancer compounds using the skeleton of tumor promoter aplysiatoxin
        Kazuhiro Irie
        The 25th Naito Conference, Chemical Biology [II] -An Emerging Field Inspired by Natural Product Chemistry- (Sapporo, Japan), 2009, Invited
      • アミロイドβタンパクの毒性コンホメーション
        入江一浩
        第54回白鷺セミナー(大阪), 2008, Invited
      • 固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析
        入江一浩
        理研シンポジウム:「第9回 分析・解析技術と化学の最先端」(東京), 2008, Invited
      • 抗がん剤の開発に向けたブライオスタチン等価体の開発
        入江一浩
        毒素研究会シンポジウム(東京), 2008, Invited
      • アミロイドβ凝集体の立体構造解析と神経細胞毒性発現機構
        入江一浩
        彩都バイオヒルズクラブ プロテオミクスシンポジウム(大阪), 2008, Invited
      • βアミロイドの立体構造解析と神経細胞毒性発現機構
        入江一浩
        第43回天然物化学談話会(大阪), 2008, Invited

      Books and Other Publications

      • 認知症, 実験医学増刊, Vol.35-No.12, 2017
        入江一浩; 村上一馬, Contributor, Analysis of the molecular structure of amyloid beta protein and its application to diagnosis, p52-59
        Yodosha, Jul. 2017, Not refereed
      • 有機化学要論
        入江一浩, Contributor, 第4章 酸と塩基, p75-91
        学術図書出版社,入江一浩, 津江広人編著, Apr. 2015, Not refereed
      • アプリシアトキシンの骨格を利用した抗がん剤シーズの開発研究
        入江一浩, Joint work
        日本化学会編,CSJ Current Review 19, 生物活性分子のケミカルバイオロジー, Chapter 12, p127-133, 2015, Not refereed
      • Potential role of vitamin C in the prevention of Alzheimer’s disease
        K. Murakami; K. Irie; T. Shimizu, Joint work
        Elsevier, C. R. Martin and V. R. Prredy (Eds.), Diet and Nutrition in Dementia and Cognitive Decline, p.663-668, 2015, Not refereed
      • 固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発
        村上一馬; 増田裕一; 入江一浩, Joint work
        メディカル ドゥ,遺伝子医学MOOK 21号,最新ペプチド合成技術とその創薬研究への応用,p211-216, 2012, Not refereed
      • Identification of toxic conformation in Aβ42 aggregates using solid-state NMR
        Y. Masuda; S. Uemura; R. Ohashi; A. Nakanishi; K. Takegoshi; K. Irie, Single work
        Peptide Science 2008, p25-28, 2009, Not refereed
      • 'Malignant' conformation of Alzheimer's beta peptide (Abeta42) through radical formation
        K. Murakami; K. Irie; H. Ohigashi; H. Hara; M. Nagao; T. Shimizu; T. Shirasawa, Single work
        Peptide Science 2006, p19-20, 2006, Not refereed
      • New aggregation model of amyloid β by the systematic proline replacement
        K. Murakami; K. Irie; A. Morimoto; Y. Masuda; H. Ohigashi; M. Nagao; H. Fukuda; T. Shimizu; T. Shirasawa, Single work
        Peptide Science 2004, p179-182, 2005, Not refereed
      • Tumor-promoting phorbol esters bind directly to the regulatory domain of diacylglycerol kinase gamma
        M. Shindo; K. Irie; H. Ohigashi; M. Kuriyama; N. Saito, Single work
        Peptide Science 2001, p207-210, 2002, Not refereed
      • Selective binding of tumor promoters to the novel PKC C1B domains
        K. Irie; A. Nakahara; Y. Nakagawa; H. Ohigashi; M. Shindo; H. Fukuda; H. Konishi; U. Kikkawa, Single work
        Peptide Science 2000, p197-200, 2001, Not refereed
      • Synthesis and phorbol ester binding of the zinc-finger like sequences of all protein kinase C isozymes
        K. Irie; K. Oie; A. Nakahara; Y. Yanai; H. Ohigashi; H. Fukuda; P. A. Wender, Single work
        Peptide Science 1998, p65-68, 1999, Not refereed
      • Synthesis and characterization of model peptides incorporating the phorbol ester-binding domain of protein kinase C
        K. Irie; Y. Yanai; H. Ohigashi; P. A. Wender, Single work
        Peptide Chemistry 1996, 209-212, 1997, Not refereed
      • A convenient synthesis of chlorin e6 dimer and trimer
        T. Ando; K. Irie; K. Koshimizu; S. Nakajima; T. Takemura; I. Sakata, Single work
        Photodynamic Therapy and Biomedical Lasers (Elsevier Science Publishers B.V.), 764-768, 1992, Not refereed
      • The indole alkaloid tumor promoter teleocidins as Epstein-Barr virus inducers: structure, biosynthesis and structure-activity relationship
        K. Irie; K. Koshimizu, Single work
        Natural Products as Antiviral Agents (Plenum), 257-273, 1992, Not refereed

      Industrial Property Rights

      • 特許第6170908号, 特願2014-511223, 新規アプリシアトキシン誘導体及びそれを含有する抗がん剤
        入江一浩; 菊森将之; 蒲池弘明; 柳田 亮; 中川 優
      • 特願2014-251898,2015-104411, アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体
        入江一浩; 村上一馬; 清水孝彦; 泉尾直孝; 清藤 勉
      • 特許US 8,710,193; CN ZL201080046483.9, Antibody recognizing turn structure in amyloid β
        Irie, K; Murakami, K; Masuda, Y; Shimizu, T; Shirasawa, T; Seito, T
      • 特願2009-239542, アミロイドβのターン構造を認識する抗体
        入江一浩; 村上一馬; 増田裕一; 清水孝彦; 白澤卓二; 清藤 勉

      Awards

      • 25 Mar. 2019
        Japan Society for Bioscience, Biotechnology, and Agrochemistry, Japan Society for Bioscience, Biotechnology, and Agrochemistry Award in 2019
        Japan, Japan society
      • 2009
        Japan Society for Bioscience, Biotechnology, and Agrochemistry, Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry in 2008
      • 1994
        Japan Society for Bioscience, Biotechnology, and Agrochemistry, Japan Society for Bioscience, Biotechnology and Agrochemistry Award for the Encouragement of Young Scientists
      • 1990
        Inoue Foundation for Science, Inoue Research Aid for Young Scientists
      • 30 Sep. 2016
        日本学術振興会, 平成28年度科研費 審査委員表彰

      External funds: Kakenhi

      • Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 37:Biomolecular chemistry and related fields
        Kyoto University
        入江 一浩
        From 01 Apr. 2019, To 31 Mar. 2024, Granted
        脳神経疾患;アルツハイマー病;アミロイドβ;抗体;毒性オリゴマー;有機化学;ジスルフィド架橋
      • Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Kyoto University
        入江 一浩
        From 30 Jun. 2017, To 31 Mar. 2022, Granted
        シグナル伝達;癌;有機化学;薬理学;酵素;プロテインキナーゼC;アプリシアトキシン;CH/π相互作用;機械学習;アロタケタール;プロテインキナーゼC;マクラマイシン;ヒト免疫不全ウイルス;発がんプロモーター;がん細胞増殖抑制
      • Frontiers in Chemical Communications
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Kyoto University
        掛谷 秀昭
        From 30 Jun. 2017, To 31 Mar. 2022, Granted
        化学コミュニケーション;分子社会学;天然物化学;ケミカルバイオロジー;生物活性リガンド
      • Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
        Grant-in-Aid for Challenging Exploratory Research
        Fukui Prefectural University
        Yoichi KUROKAWA
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        抗酸化能;プロオキシダント能;銅イオン還元能;ヒドロキシルラジカル;スーパーオキシドディスムターゼ 1;蛋白質変性;antioxidant;prooxidant;copper-induced oxidation;hydroxyl radical;superoxide dismutase;G6PDH;protein stability;抗酸化;プロオキシダント性;分子酸化
      • アミロイドβの毒性配座理論に基づいたアルツハイマー病の新規診断法の開発
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        入江 一浩
        From 01 Apr. 2014, To 31 Mar. 2018, Adopted
      • Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
        Grant-in-Aid for Scientific Research (S)
        Kyoto University
        Kazuhiro Irie
        From 30 May 2014, To 31 Mar. 2019, Project Closed
        アルツハイマー病;アミロイドβ;毒性ターン;凝集;抗体;脳脊髄液;診断;フラボノイド;脳神経疾患;有機化学;核酸アプタマー;ノックインマウス;毒性オリゴマー;アルツハイマー;オリゴマー;神経細胞毒性
      • A new strategy for designing mannose receptors based on enantiomers of protein domains.
        Grant-in-Aid for Challenging Exploratory Research
        Nagoya University
        Yu NAKAGAWA
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        生理活性;蛋白質;糖;有機合成;タンパク質
      • Search for Inhibitors of Amyloid beta Aggregation from Edible Plants and Their Mechanism
        Grant-in-Aid for Scientific Research (C)
        University of Tsukuba
        Hideyuki SHIGEMORI
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        アミロイドβ凝集阻害活性;アルツハイマー病;Th-T;カフェ酸誘導体;HGF産生促進活性;サツマイモ;コーヒー;神経細胞保護作用;Aβ凝集阻害活性;アルツハイマー症;キノコ;地骨皮;ビスフラボノイド;HGF;カフェオイルキナ酸;フェニルエタノイド配糖体;記憶障害改善;プロポリス
      • Search for novel PKC ligands as therapeutic seeds for intractable diseases
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Kazuhiro IRIE
        From 01 Apr. 2011, To 31 Mar. 2013, Project Closed
        海洋天然物;ブリオスタチン;プロテインキナーゼC;がん;アルツハイマー病;プロテインキナーゼC;ホルボールエステル;海綿;珪藻;発がん促進物質;フサコケムシ;ラン藻;Epstein-Barrウィルス
      • Development and mechanistic analysis of new PKC ligands as anti-cancer agents
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Kyoto University
        Kazuhiro IRIE
        From 01 Apr. 2011, To 31 Mar. 2016, Project Closed
        アプリシアトキシン;アプログ;ブリオスタチン;がん細胞増殖抑制;プロテインキナーゼC;ホルボールエステル;発がんプロモーター;抗がん剤;シグナル伝達;debromoaplysiatoxin;bryostatin;phorbol ester;発がん促進;ヒトがん細胞;増殖抑制;がん細胞;aplysiatoxin;発がん促進物質;細胞増殖抑制活性;プロテインキナーゼC;発がん2段階試験;TPA
      • Chemical biology using natural products
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Tohoku University
        Minoru UEDA
        From 01 Apr. 2011, To 31 Mar. 2016, Project Closed
        天然物;ケミカルバイオロジー;標的同定;天然物化学;天然物リガンド;国際交流(ドイツ);国際交流(米国);国際交流(韓国);国際交流(スウェーデン);異分野融合;国際研究者交流(米国);国際研究者交流(中国);国際研究者交流(韓国);天然物ケミカルバイオロジー;分子設計
      • Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Kazuhiro IRIE
        From 01 Apr. 2009, To 31 Mar. 2014, Project Closed
        アルツハイマー病;アミロイドβ;凝集;毒性ターン;抗体;フラボノイド;オリゴマー;アルツハイマー;凝集抑制;カテコール;Aβ42;βアミロイド;タキシフォリン;プロテインキナーゼC;クルクミン;シナプス毒性;アプリシアトキシン;抗ターン抗体;毒性コンホマー;光アフィニティーラベリング
      • インドール環4位への窒素原子導入酵素の触媒機構の解析と応用
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        入江 一浩
        From 01 Apr. 2008, To 31 Mar. 2010, Project Closed
        indolactam-V;teleocidin;生合成;NRPS;P450;発がんプロモーター;Streptomyces
      • Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation model
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Kazuhiro IRIE
        From 01 Apr. 2006, To 31 Mar. 2009, Project Closed
        アルツハイマー病;βアミロイド;凝集;固体NMR;β-シート;Aβ抗体;ESR;アルツハイマ-病;β-シ-ト;アルツハイマー;Aβ42;R2;βシート;シリマリン;タキシフォリン;DARR;スピンラベル
      • CH/π相互作用を利用したPKCアイソザイム選択的な薬剤開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Science and Engineering
        Kyoto University
        入江 一浩
        From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
        インドラクタム;C1ドメイン;CH;π相互作用;発がんプロモーター;プロテインキナーゼC;ホルボールエステル
      • CH/π相互作用を利用したPKCδ選択的薬剤の創製
        Grant-in-Aid for Scientific Research on Priority Areas
        Science and Engineering
        Kyoto University
        入江 一浩
        From 01 Apr. 2005, To 31 Mar. 2006, Project Closed
        プロテインキナーゼC;インドラクタム;CH;π相互作用;C1ドメイン;発がんプロモーター;ベンゾラクタム
      • アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Metropolitan Institute of Gerontology
        白澤 卓二
        From 01 Apr. 2005, To 31 Mar. 2006, Project Closed
        アルツハイマー病;Aβ42;βアミロイド;凝集;酸化ストレス;ラジカル;電子スピン共鳴法;ターン形成
      • Structural analysis of β-amyloid fibrils using solid-state NMR
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Kazuhiro IRIE
        From 01 Apr. 2004, To 31 Mar. 2006, Project Closed
        アルツハイマー;Aβ42;βアミロイド;β-シート;凝集;固体NMR;DARR;ターン;ベータシート, Alzheimer's disease;Aβ42;amyloid;β-sheet;aggregation;solid-state NMR;DARR;turn
      • 質量分析法によるリガンド-レセプター相互作用の精密解析
        Grant-in-Aid for Exploratory Research
        Kyoto University
        入江 一浩
        From 01 Apr. 2003, To 31 Mar. 2005, Project Closed
        プロテインキナーゼC;エレクトロスプレー質量分析計;亜鉛フィンガー;ホルボールエステル;亜鉛放出;カドミウム
      • Development of new agents that regulate cellular signal transduction
        Grant-in-Aid for Scientific Research (A)
        KYOTO UNIVERSITY
        Hajime OHIGASHI
        From 01 Apr. 2003, To 31 Mar. 2007, Project Closed
        アプリシアトキシン;ジアシルグリセロールキナーゼ;C1 ドメイン;インドラクタム;発がんプロモーター;ブライオスタチン;プロテインキナーゼ C;ホルボールエステル;亜鉛フィンガー;C1ドメイン;プロテインキナーゼC;GFP;RasGRP;chimaerin;Unc13;indolactam-V, aplysiatoxin;bryostatin;C1 domain;diacylglycerol kinase;indolactam;phorbol ester;protein kinase C;tumor promoter
      • Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitors
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Kazuhiro IRIE
        From 01 Apr. 2001, To 31 Mar. 2004, Project Closed
        アルツハイマー;Aβ42;アミロイド;ベータシート;ターン;家族性アルツハイマー;βアミロイド;凝集;β-sheet;β-turn;家族性アルツハイマー病;Aβ1-42, Alzheimer's disease;Aβ42;amyloid;β-sheet;turn;familial Alzheimer's disease
      • 発がんプロモーションのメカニズム解明のための鍵化合物の開発と応用
        Grant-in-Aid for Scientific Research on Priority Areas
        Science and Engineering
        Kyoto University
        入江 一浩
        From 01 Apr. 2001, To 31 Mar. 2003, Project Closed
        ホルボールエステル;プロテインキナーゼC;発がんプロモーター;インドラクタム;システインリッチドメイン;コンホメーション;ジアシルグリセロールキナーゼ
      • 発がんプロモーションのメカニズム解明のための鍵化合物の開発
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Science and Engineering
        Kyoto University
        入江 一浩
        From 01 Apr. 2000, To 31 Mar. 2001, Project Closed
        ホルボールエステル;プロテインキナーゼC;発がんプロモーター;インドラクタム;システインリッチドメイン
      • Synthesis and characterization of the regulatory domains of protein kinase C
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Kazuhiro IRIE
        From 01 Apr. 1999, To 31 Mar. 2001, Project Closed
        ホルボールエステル;プロテインキナーゼC;発がんプロモーター;亜鉛フィンガー;固相合成;エレクトロスプレー質量分析法;HATU, cysteine-rich domain;phorbol;protein kinase C;tumor promoter;zinc finger
      • Synthesis and PKC binding of conformationally restricted indolactams by aza-Claisen rearrangement
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Kazuhiro IRIE
        From 01 Apr. 1996, To 31 Mar. 1998, Project Closed
        アザクライゼン転位;テレオシジン;インドラクタム;発がんプロモーター;プロテインキナーゼC;コンフォメーション, aza-Claisen rearrangement;teleocidin;indolactam;tumor promoter;protein kinase C;conformation
      • 発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        入江 一浩
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        発癌プロモーター;プロテインキナーゼC;光アフィニティーラベリング;ホルボールエステル;ジアジリン
      • 新規水溶性フラーレン誘導体の合成とフォトダイナミックアクション
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Kyoto University
        入江 一浩
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        フラーレン;光細胞毒性;光物理化学療法;ポルフィリン
      • 発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        入江 一浩
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        発癌プロモーター;プロテインキナーゼC;光アフィニティーラベリング;ホルボールエステル;ジアゾアセチル基
      • 立体配座を固定した発癌プロモーター・テレオシジン誘導体の合成と生物活性
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Kyoto University
        入江 一浩
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        発癌プロモーター;インドラクタム;テレオシジン;コンフォメーション;アザ・コープ転位;プロテインキナーゼC;EBウイルス
      • 発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        入江 一浩
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        発癌プロモーター;プロテインキナーゼC;光アフィニティーラベリング;フォルボールエステル;ジアゾアセチル基
      • プロテインキナーゼCの光アフィニティーラベリング
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Kyoto University
        入江 一浩
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        発癌プロモーター;光アフィニティーラベリング;プロテインキナーゼC;インドラクタム;テレオシジン;フォルボールエステル
      • Character and Application of the Cyclization Enzyme at position 4 of an indole ring.
        Grant-in-Aid for General Scientific Research (B)
        KYOTO UNIVERSITY
        Koichi KOSHIMIZU
        From 01 Apr. 1991, To 31 Mar. 1993, Project Closed
        インドラクタム;テレオシジン;発癌プロモーター;生合成;微生物転換;閉環酵素;発癌プロモ-タ-, (-)-Indolactam-V;Teleocidin;Tumor promoter;Biosynthesis;Cyclization enzyme;Microbial conversion
      • 細胞膜で多彩に機能する有機化合物の合成化学的開発
        Grant-in-Aid for Scientific Research (B)
        Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
        Yokohama City University
        及川 雅人
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        ポリアミン;ペプチド;ドラッグデリバリーシステム;シナプス受容体モジュレーター

      External funds: others

      • 天然PKCリガンドの医薬品シーズとしての構造最適化
        上原記念生命科学財団 2016年度研究助成
        From 08 Feb. 2017, To 30 Apr. 2018
        入江一浩
      • Aβオリゴマーの毒性配座理論を基盤としたアルツハイマー病の治療戦略
        武田科学振興財団 2013年度生命科学研究助成
        From 01 Oct. 2013, To 31 May 2016
        入江一浩
      • 食品中のポリフェノール類によるアミロイドβの毒性緩和機構
        アサヒグループ学術振興財団 2010年度研究助成
        From 07 Feb. 2008, To 31 Mar. 2012
        入江一浩
      • ブライオスタチンのプロテイキナーゼC活性化機構に基づいた新規抗がん剤の設計
        上原記念生命科学財団 2007年度研究助成
        From 01 Apr. 2008, To 30 Apr. 2009
        入江一浩
      • プロテインキナーゼCアイソザイムを標的とした新しい抗がん剤の設計
        内藤記念科学振興財団 2006年度研究助成
        From 01 Apr. 2007, To 31 Mar. 2008
        入江一浩
      • Daphnoretinをリードとした抗がん剤の開発
        松籟科学技術振興財団 2006年度研究助成
        From 01 Apr. 2007, To 31 Mar. 2008
        入江一浩
      list
        Last Updated :2022/10/02

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Organic Chemistry in Food Science II
          7209, Spring, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Organic Chemistry in Food Science III
          7218, Fall, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar of Organic Chemistry in Life Science1
          GB13, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Experimental Course of Organic Chemistry in Life Science2
          GC14, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Outline of Physiological Chemistry
          X101, Fall, Graduate School of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Organic Chemistry in Food Science I
          7207, Fall, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar of Organic Chemistry in Life Science2
          GB14, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Experimental Course of Organic Chemistry in Life Science1
          GC13, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Course of Natural Products Chemistry
          GA26, Spring, Graduate School of Agriculture, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Course in Organic Chemistry in Food Science
          7280, Spring, Faculty of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Organic Chemistry
          7315, Fall, Faculty of Agriculture, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Outline of Physiological Chemistry
          M212, Fall, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Food Bioscience
          7215, Spring, Faculty of Agriculture, 2
        • Faculty of Agriculture: Organic Chemistry in Food Science I, II, III, Organic Chemistry in Life Science, Laboratory Course in Organic Chemistry, Introduction and Practice in the Department of Food Science and Biotechnology
        • Graduate School of Agriculture: Organic Chemistry in Life Science, Food and Life Science (Advanced Course), Seminar of Organic Chemistry in Life Science, Experimental Course of Organic Chemistry in Life Science
        • From Apr. 2011, To Mar. 2012
          食品有機化学I
          Fall, 農学部
        • From Apr. 2011, To Mar. 2012
          食品有機化学II
          Spring, 農学部
        • From Apr. 2011, To Mar. 2012
          食品有機化学III
          Fall, 農学部
        • From Apr. 2011, To Mar. 2012
          生命有機化学
          Spring, 農学部
        • From Apr. 2011, To Mar. 2012
          有機化学実験及び実験法
          Spring, 農学部
        • From Apr. 2012, To Mar. 2013
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2012, To Mar. 2013
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2012, To Mar. 2013
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2012, To Mar. 2013
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2012, To Mar. 2013
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2012, To Mar. 2013
          Seminar on Food Science and Biotechnology
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2013, To Mar. 2014
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2013, To Mar. 2014
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2013, To Mar. 2014
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2014, To Mar. 2015
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Life Science
          Spring, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Outline of Physiological Chemistry
          Fall, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2015, To Mar. 2016
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Outline of Physiological Chemistry
          Fall, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2015, To Mar. 2016
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2015, To Mar. 2016
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2015, To Mar. 2016
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2016, To Mar. 2017
          Natural Products Chemistry
          Spring, 農学部
        • From Apr. 2016, To Mar. 2017
          Organic Chemistry in Life Science
          Spring, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Food Science and Production Technology
          Spring, 農学部
        • From Apr. 2016, To Mar. 2017
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2016, To Mar. 2017
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2016, To Mar. 2017
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2016, To Mar. 2017
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2017, To Mar. 2018
          Natural Products Chemistry
          Spring, 農学部
        • From Apr. 2017, To Mar. 2018
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Course of Bioorganic Chemistry
          Spring, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2017, To Mar. 2018
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2017, To Mar. 2018
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2017, To Mar. 2018
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2018, To Mar. 2019
          Natural Products Chemistry
          Spring, 農学部
        • From Apr. 2018, To Mar. 2019
          Advanced Course of Natural Products Chemistry
          Spring, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Outline of Physiological Chemistry
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2018, To Mar. 2019
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2018, To Mar. 2019
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2018, To Mar. 2019
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2019, To Mar. 2020
          Seminar on Organic Chemistry
          Fall, 農学部
        • From Apr. 2019, To Mar. 2020
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Course of Bioorganic Chemistry
          Spring, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2019, To Mar. 2020
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2019, To Mar. 2020
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2020, To Mar. 2021
          Advanced Course of Natural Products Chemistry
          Spring, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Organic Chemistry
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2020, To Mar. 2021
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Organic Chemistry in Food Science
          Year-long, 農学部
        • From Apr. 2021, To Mar. 2022
          Seminar on Organic Chemistry
          Fall, 農学部
        • From Apr. 2021, To Mar. 2022
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Course of Bioorganic Chemistry
          Spring, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2021, To Mar. 2022
          Organic Chemistry in Food Science II
          Spring, 農学部
        • From Apr. 2021, To Mar. 2022
          Organic Chemistry in Food Science I
          Fall, 農学部
        • From Apr. 2021, To Mar. 2022
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2021, To Mar. 2022
          Introduction to Food Bioscience
          Spring, 農学部

        Part-time lecturer

        • From 09 Apr. 2013, To 30 Sep. 2013
          生命有機化学
          平成25年度前期集中, 広島大学, 大学院理学研究科
        • From 09 Apr. 2014, To 30 Sep. 2014
          天然物有機化学
          平成26年度前期集中, 広島大学, 理学部
        • From 08 Apr. 2015, To 30 Sep. 2015
          天然物有機化学
          平成27年度前期集中, 広島大学, 大学院理学研究科
        • From 01 Sep. 2015, To 31 Mar. 2016
          ケミカルバイオロジー特論
          平成27年度後期, 東京大学, 大学院薬学系研究科
        • From 01 Apr. 2016, To 30 Sep. 2016
          天然物有機化学
          2016年前期集中, 広島大学, 大学院理学研究科
        • From 01 Apr. 2017, To 30 Sep. 2017
          天然物有機化学Ⅰ
          2017年前期集中, 広島大学, 大学院理学研究科
        list
          Last Updated :2022/10/02

          Administration

          School management (title, position)

          • From 01 Apr. 2022
            大学評価委員会点検・評価実行委員会 委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            国際高等教育院 企画評価専門委員会 化学部会 委員
          • 放射線取扱主任者(農学研究科)、京都大学全学共通科目化学部会委員、低温物質科学研究センター協議員会協議員
          • From 01 Oct. 2008, To 30 Sep. 2010
            総長室特命補佐
          • From 01 Apr. 2011, To 31 Mar. 2013
            設備整備ワーキンググループ 委員
          • From 01 Oct. 2012, To 30 Sep. 2016
            吉田キャンパスマスタープラン専門部会 部会員
          • From 01 Jun. 2014, To 31 Mar. 2022
            国際高等教育院企画評価専門委員会化学部会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            学際融合教育研究推進センター運営委員会 委員
          • From 01 Apr. 2005, To 31 Mar. 2013
            高等教育研究開発推進機構基礎教育専門委員会・化学部会 委員
          • From 01 Apr. 2010, To 31 Mar. 2016
            低温物質科学研究センター協議員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2017
            放射性同位元素等専門委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2016
            学際融合教育研究推進センター生理化学研究ユニット長
          • From 01 Apr. 2020, To 31 Mar. 2021
            障害者入試委員会 委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            国際高等教育院企画評価専門委員会化学部会 委員
          • From 01 Jan. 2020, To 31 Mar. 2020
            特色入試入学者追跡調査WG 
          • From 01 Apr. 2020, To 31 Mar. 2022
            入学試験実施委員会 委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            国際高等教育院企画評価専門委員会化学部会 委員

          Faculty management (title, position)

          • From 01 Apr. 2014, To 31 Mar. 2016
            FD委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2016
            学部教務委員会 委員
          • From 01 Apr. 2015, To 31 Mar. 2023
            建築委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2017
            放射線障害防止委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2018
            食品生物科学科 学科長
          • From 01 Apr. 2016, To 31 Mar. 2020
            評価委員会 委員
          • From 01 Apr. 2017, To 31 Mar. 2023
            将来構想検討委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2020
            防火・防災委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2020
            食品生物科学専攻 専攻長
          • From 01 Apr. 2020, To 31 Mar. 2024
            学部教務委員会 委員

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