Hosokawa, Nobuko(Institute for Life and Medical Sciences (LiMe)) | Activity Database on Education and Research, Kyoto University

Hosokawa, Nobuko

Institute for Life and Medical Sciences (LiMe) Associate Professor

Last Updated :2022/08/06

Basic Information

Affiliated programs (koza)

Graduate School of Science, 生物科学専攻生物物理学（分子細胞生物学）, 准教授

Graduate School of Medicine, 医学専攻細胞機能調節学, 准教授

Graduate School of Medicine, 医科学専攻細胞機能調節学, 准教授

Professional Memberships

日本生化学会

日本分子生物学会

日本細胞生物学会

Academic Degree

博士（医学）(京都府立医科大学)

Academic Resume (Graduate Schools)

京都府立医科大学大学院, 医学研究科博士課程, 社会医学系, 単位取得退学

Academic Resume (Undergraduate School/Majors)

京都府立医科大学, 医学部医学科, 卒業

京都府立医科大学, 医学部医学進学課程, 修了

High School

High School
奈良女子大学文学部附属高等学校

Language of Instruction

English

ID,URL

ORCID ID
0000-0002-8584-6966
J-Global ID
200901063396558394

researchmap URL

https://researchmap.jp/HOSOKAWA_Nobuko

Last Updated :2022/08/06

Research

Research Topics, Overview of the research

Research Topics
Research on the quality control mechanism of proteins
Overview of the research
Newly synthesized polypeptides acquire their native conformations to be functional, and proteins that failed to fold properly or that are misfolded due to cellular stresses are degraded within the cells. This system is called as the quality control mechanism of proteins. I study the cellular mechanism of the protein quality control.

Research Interests

生化学

分子生物学

細胞生物学

Biochemistry

Molecular Biology

Cell Biology

Research Areas

Life sciences, Medical biochemistry

Life sciences, Cell biology

Life sciences, Molecular biology

Papers

Reconstitution of cell cycle-dependent morphological chanbes of the endoplasmic reticulum in semi-intact CHO cells
Murata M.; Kano F.; Kondo H.; Hosokawa N.; Nagata K.
Seibutsu Butsuri, 2001

SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine‐expanded protein
Tokuya Hattori; Ken Hanafusa; Ikuo Wada; Nobuko Hosokawa
The FEBS Journal, 02 Mar. 2021, Peer-reviewed, Corresponding author

Visualization of procollagen IV reveals ER-to-Golgi transport by ERGIC-independent carriers.
Matsui Y; Hirata Y; Wada I; Hosokawa N
Cell Structure and Function, 2020, Peer-reviewed, Last author, Corresponding author

In vitro Mannosidase Assay of EDEMs: ER Degradation-Enhancing α-Mannosidase-Like Proteins
HOSOKAWA Nobuko
Lectin Purification and Analysis: Methods and Protocols, 2020, Invited

SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein.
Hanafusa K; Wada I; Hosokawa N
Journal of Biological Chemistry, 2019, Peer-reviewed, Last author, Corresponding author

ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation–enhancing α-mannosidase–like protein 3 (EDEM3)
YU Shangyu; ITO Shinji; WADA Ikuo; HOSOKAWA Nobuko
Journal of Biological Chemistry, 2018, Peer-reviewed

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation
Tsutomu Fujimori; Ryoji Suno; Shun-Ichiro Iemura; Tohru Natsume; Ikuo Wada; Nobuko Hosokawa
GENES TO CELLS, Aug. 2017, Peer-reviewed

Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L
Nobuko Hosokawa; Ikuo Wada
FEBS JOURNAL, Jan. 2016, Peer-reviewed

N-glycans and Quality control of proteins.
HOSOKAWA Nobuko; SUZUKI Takashi
“Sugar Chains. Decoding the Function of Glycans” (Eds. T. Suzuki, K. Ohtsubo, N. Taniguchi), 2015, Invited

Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded alpha 1-antitrypsin variant
Tsutomu Fujimori; Yukiko Kamiya; Kazuhiro Nagata; Koichi Kato; Nobuko Hosokawa
FEBS JOURNAL, Mar. 2013, Peer-reviewed

Assay for endoplasmic reticulum-associated degradation (ERAD) in mammalian cells.
Hosokawa N
GlycoPOD web site : Biosynthesis & Metabolism (Ed. T. Kawasaki) (2012), 2012, Peer-reviewed

SEL1L Protein Critically Determines the Stability of the HRD1-SEL1L Endoplasmic Reticulum-associated Degradation (ERAD) Complex to Optimize the Degradation Kinetics of ERAD Substrates
Yasutaka Iida; Tsutomu Fujimori; Katsuya Okawa; Kazuhiro Nagata; Ikuo Wada; Nobuko Hosokawa
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2011, Peer-reviewed

[要修正] ERAD(小胞体関連分解)を制御するレクチンOS-9とXTP3-B
細川暢子
生化學, 25 Jan. 2011, Peer-reviewed

OS-9 and XTP3-B: Lectins that regulate endoplasmic reticulum-associated degradation (ERAD)
Nobuko Hosokawa
Seikagaku, 2011, Peer-reviewed

The role of MRH domain-containing lectins in ERAD
Nobuko Hosokawa; Yukiko Kamiya; Koichi Kato
GLYCOBIOLOGY, Jun. 2010, Peer-reviewed

EDEM1 accelerates the trimming of alpha 1,2-linked mannose on the C branch of N-glycans
Nobuko Hosokawa; Linda O. Tremblay; Barry Sleno; Yukiko Kamiya; Ikuo Wada; Kazuhiro Nagata; Koichi Kato; Annette Herscovics
GLYCOBIOLOGY, May 2010, Peer-reviewed

MANNOSE 6-PHOSPHATE RECEPTOR HOMOLOGY DOMAIN-CONTAINING LECTINS IN MAMMALIAN ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION
Nobuko Hosokawa; Koichi Kato; Yukiko Kamiya
METHODS IN ENZYMOLOGY, VOL 480: GLYCOBIOLOGY, 2010, Invited

Human OS-9, a Lectin Required for Glycoprotein Endoplasmic Reticulum-associated Degradation, Recognizes Mannose-trimmed N-Glycans
Nobuko Hosokawa; Yukiko Kamiya; Daiki Kamiya; Koichi Kato; Kazuhiro Nagata
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2009, Peer-reviewed

ANIMAL LECTINS A Functional View
N. Hosokawa; K. Nagata
M-type lectins as novel components of secretory pathways, (Eds Gerardo R.Vasta, Hafiz Ahmed) CRC Press pp. 165－169（2009）, 2009, Peer-reviewed

Targeted disruption of Hsp110/105 gene protects against ischemic stress
Junji Nakamura; Motoaki Fujimoto; Kunihiko Yasuda; Kiyoshi Takeda; Shizuo Akira; Takumi Hatayama; Yasushi Takagi; Kazuhiko Nozaki; Nobuko Hosokawa; Kazuhiro Nagata
STROKE, Oct. 2008, Peer-reviewed

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP
Nobuko Hosokawa; Ikuo Wada; Koji Nagasawa; Tatsuya Moriyama; Katsuya Okawa; Kazuhiro Nagata
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2008, Peer-reviewed

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508
Daisuke Morito; Kazuyoshi Hirao; Yukako Oda; Nobuko Hosokawa; Fuminori Tokunaga; Douglas M. Cyr; Keiji Tanaka; Kazuhiro Iwai; Kazuhiro Nagata
MOLECULAR BIOLOGY OF THE CELL, Apr. 2008, Peer-reviewed

Degradation of misfolded plycoproteins in the endoplasmic reticulum
N. Hosokawa
"Experimental Glycoscience : Glycology" (Eds N. Taniguchin et al.) Springer pp. 207-210 (2008), 2008, Peer-reviewed

Stimulation of ERAD of misfolded null Hong Kong alpha 1-antitrypsin by golgi alpha 1,2-mannosidases
Nobuko Hosokawa; Zhipeng You; Linda O. Tremblay; Kazuhiro Nagata; Annette Herscovics
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2007, Peer-reviewed

Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation
Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Randal J. Kaufman; Kazuhiro Nagata
EMBO REPORTS, May 2007, Peer-reviewed

EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha 1-antitrypsin
N Hosokawa; Wada, I; Y Natsuka; K Nagata
GENES TO CELLS, May 2006, Peer-reviewed

EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming
K Hirao; Y Natsuka; T Tamura; Wada, I; D Morito; S Natsuka; P Romero; B Sleno; LO Tremblay; A Herscovics; K Nagata; N Hosokawa
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2006, Peer-reviewed

NSF/SNAPs and p97/p47/VCIP135 are sequentially required for cell cycle-dependent reformation of the ER network
F Kano; H Kondo; A Yamamoto; Y Kaneko; K Uchiyama; N Hosokawa; K Nagata; M Murata
GENES TO CELLS, Oct. 2005, Peer-reviewed

[要修正] 小胞体タンパク質の品質を保証する細胞内メカニズム
細川暢子
化学と生物, Sep. 2005, Peer-reviewed

The maintenance of the endoplasmic reticulum network is regulated by p47, a cofactor of p97, through phosphorylation by cdc2 kinase
F Kano; H Kondo; A Yamamoto; AR Tanaka; N Hosokawa; K Nagata; M Murata
GENES TO CELLS, Apr. 2005, Peer-reviewed

[要修正] 胞体関連分解におけるEDEM ファミリータンパク質の機能
長束優子; 細川暢子; 永田和宏
実験医学「細胞内タンパク質の社会学」（永田和宏，遠藤斗志也編）Vol. 23, No. 15 : 2352－2357(2005), 2005, Peer-reviewed

Insufficient folding of type IV collagen and formation of abnormal basement membrane-like structure in embryoid bodies derived from Hsp47-null embryonic stem cells
Y Matsuoka; H Kubota; E Adachi; N Nagai; T Marutani; N Hosokawa; K Nagata
MOLECULAR BIOLOGY OF THE CELL, Oct. 2004, Peer-reviewed

[要修正] ER quality control and ERAD: EDEM accelerates glycoprotein ERAD
N. Hosokawa
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2004, Peer-reviewed

[要修正] 小胞体タンパク質品質管理とERAD－EDEM 分子は糖タンパク質のERAD を促進する
細川暢子
蛋白質核酸酵素「細胞における蛋白質の一生」Vol.49,No.7 : 984－987（2004）, 2004, Peer-reviewed

Enhancement of endoplasmic reticulum (ER) degradation of misfolded null Hong Kong alpha(1)-antitrypsin by human ER mannosidase I
N Hosokawa; LO Tremblay; ZP You; A Herscovics; Wada, I; K Nagata
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2003, Peer-reviewed

[要修正] ＥＲＡＤによる品質管理機構
細川暢子; 永田和宏
生化学, 25 Jun. 2003, Peer-reviewed

EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin
Y Oda; N Hosokawa; Wada, I; K Nagata
SCIENCE, Feb. 2003, Peer-reviewed

A time-dependent phase shift in the mammalian unfolded protein response
H Yoshida; T Matsui; N Hosokawa; RJ Kaufman; K Nagata; K Mori
DEVELOPMENTAL CELL, Feb. 2003, Peer-reviewed

The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chaperone
K Yasuda; K Hirayoshi; H Hirata; H Kubota; N Hosokawa; K Nagata
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2002, Peer-reviewed

Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary
K Sato; K Yomogida; T Wada; T Yorihuzi; Y Nishimune; N Hosokawa; K Nagata
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

Heat shock protein (HSP) 47 and collagen are upregulated during neointimal formation in the balloon-injured rat carotid artery
S Murakami; Y Toda; T Seki; E Munetomo; Y Kondo; T Sakurai; Y Furukawa; M Matsuyama; T Nagate; N Hosokawa; K Nagata
ATHEROSCLEROSIS, Aug. 2001, Peer-reviewed

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation
N Hosokawa; Wada, I; K Hasegawa; T Yorihuzi; LO Tremblay; A Herscovics; K Nagata
EMBO REPORTS, May 2001, Peer-reviewed

Mnl1p, an alpha-mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins
K Nakatsukasa; S Nishikawa; N Hosokawa; K Nagata; T Endo
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2001, Peer-reviewed

Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid
M Naitoh; N Hosokawa; H Kubota; T Tanaka; H Shirane; M Sawada; Y Nishimura; K Nagata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2001, Peer-reviewed

Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences
M Matsuda; T Koide; T Yorihuzi; N Hosokawa; K Nagata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2001, Peer-reviewed

Embryonic lethality of molecular chaperone Hsp47 knockout mice is associated with defects in collagen biosynthesis
N Nagai; M Hosokawa; S Itohara; E Adachi; T Matsushita; N Hokawa; K Nagata
JOURNAL OF CELL BIOLOGY, Sep. 2000, Peer-reviewed

Procollagen binds to both prolyl 4-hydroxylase/protein disulfide isomerase and HSP47 within the endoplasmic reticulum in the absence of ascorbate
N Hosokawa; K Nagata
FEBS LETTERS, Jan. 2000, Peer-reviewed

Separate cis-acting DNA elements control cell type- and tissue-specific expression of collagen binding molecular chaperone HSP47
H Hirata; Yamamura, I; K Yasuda; A Kobayashi; N Tada; M Suzuki; K Hirayoshi; N Hosokawa; K Nagata
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1999, Peer-reviewed

The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)
N Nagai; Y Tetuya; N Hosokawa; K Nagata
GENE, Feb. 1999, Peer-reviewed

Expression and localization of collagen-binding stress protein Hsp47 in mouse embryo development: comparison with types I and II collagen
H Masuda; N Hosokawa; K Nagata
CELL STRESS & CHAPERONES, Dec. 1998, Peer-reviewed

HSP47, a collagen-specific molecular chaperone, delays the secretion of type III procollagen transfected in human embryonic kidney cell line 293: A possible role for HSP47 in collagen modification
N Hosokawa; C Hohenadl; M Satoh; K Kuhn; K Nagata
JOURNAL OF BIOCHEMISTRY, Sep. 1998, Peer-reviewed

Transcriptional activation of the mouse HSP47 gene in mouse osteoblast MC3T3-E1 cells by TGF-beta 1
Yamamura, I; H Hirata; N Hosokawa; K Nagata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 1998, Peer-reviewed

Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen
M Satoh; K Hirayoshi; SI Yokota; N Hosokawa; K Nagata
JOURNAL OF CELL BIOLOGY, Apr. 1996, Peer-reviewed

Regulation and function of collagen-specific molecular chaperone, HSP47
Kazuhiro Nagata; Nobuko Hosokawa
Cell Structure and Function, 1996, Peer-reviewed

ALTERNATIVE 5' SPLICE-SITE SELECTION INDUCED BY HEAT-SHOCK
H TAKECHI; N HOSOKAWA; K HIRAYOSHI; K NAGATA
MOLECULAR AND CELLULAR BIOLOGY, Jan. 1994, Peer-reviewed

STRUCTURE OF THE GENE ENCODING THE MOUSE 47-KDA HEAT-SHOCK PROTEIN (HSP47)
N HOSOKAWA; H TAKECHI; S YOKOTA; K HIRAYOSHI; K NAGATA
GENE, Apr. 1993, Peer-reviewed

QUERCETIN, AN INHIBITOR OF HEAT-SHOCK PROTEIN-SYNTHESIS, INHIBITS THE ACQUISITION OF THERMOTOLERANCE IN A HUMAN COLON-CARCINOMA CELL-LINE
M KOISHI; N HOSOKAWA; M SATO; A NAKAI; K HIRAYOSHI; M HIRAOKA; M ABE; K NAGATA
JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1992, Peer-reviewed

INHIBITION OF THE ACTIVATION OF HEAT-SHOCK FACTOR INVIVO AND INVITRO BY FLAVONOIDS
N HOSOKAWA; K HIRAYOSHI; H KUDO; H TAKECHI; A AOIKE; K KAWAI; K NAGATA
MOLECULAR AND CELLULAR BIOLOGY, Aug. 1992, Peer-reviewed

QUERCETIN, A BIOFLAVONOID, INHIBITS THE INCREASE OF HUMAN MULTIDRUG RESISTANCE GENE (MDR1) EXPRESSION CAUSED BY ARSENITE
N KIOKA; N HOSOKAWA; T KOMANO; K HIRAYOSHI; K NAGATA; K UEDA
FEBS LETTERS, Apr. 1992, Peer-reviewed

FLAVONOIDS INHIBIT THE EXPRESSION OF HEAT-SHOCK PROTEINS
N HOSOKAWA; K HIRAYOSHI; A NAKAI; Y HOSOKAWA; N MARUI; M YOSHIDA; T SAKAI; H NISHINO; A AOIKE; K KAWAI; K NAGATA
CELL STRUCTURE AND FUNCTION, Dec. 1990, Peer-reviewed

N-MYC SUPPRESSION AND CELL-CYCLE ARREST AT G1 PHASE BY PROSTAGLANDINS
N MARUI; T SAKAI; N HOSOKAWA; M YOSHIDA; A AOIKE; K KAWAI; H NISHINO; M FUKUSHIMA
FEBS LETTERS, Sep. 1990, Peer-reviewed

INHIBITORY EFFECT OF QUERCETIN ON THE SYNTHESIS OF A POSSIBLY CELL-CYCLE-RELATED 17-KDA PROTEIN, IN HUMAN COLON CANCER-CELLS
N HOSOKAWA; Y HOSOKAWA; T SAKAI; M YOSHIDA; N MARUI; H NISHINO; K KAWAI; A AOIKE
INTERNATIONAL JOURNAL OF CANCER, Jun. 1990, Peer-reviewed

THE EFFECT OF QUERCETIN ON CELL-CYCLE PROGRESSION AND GROWTH OF HUMAN GASTRIC-CANCER CELLS
M YOSHIDA; T SAKAI; N HOSOKAWA; N MARUI; K MATSUMOTO; A FUJIOKA; H NISHINO; A AOIKE
FEBS LETTERS, Jan. 1990, Peer-reviewed

Misc.

小胞体品質管理とERAD--EDEM分子は糖蛋白質のERADを促進する (細胞における蛋白質の一生--生成・成熟・輸送・管理・分解・病態) -- (蛋白質の品質管理)
細川暢子
蛋白質核酸酵素, May 2004

2P193 Cell cycle-dependent dynamics of the endoplasmic reticulum (ER) in mammalian cells (II) : Mechanism of membrane fusion of the ER
Kano F.; Kondo H.; Yamauchi S.; Tanaka A.R.; Hosokawa N.; Nagata K.; Murata M.
Seibutsu Butsuri, 2004

EMBRYOID BODIES DERIVED FROM HSP47-KNOCKOUT EMBRYONIC STEM CELLS ARE DEFICIENT IN BASEMENT MEMBRANE FORMATION DURING EMBRYONIC DEVELOPMENT
Matsuoka Yasuhiro; Adachi Eijiro; Nagai Naoko; Hosokawa Nobuko; Kubota Hiroshi; Nagata Kazuhiro
Connective tissue, Apr. 2002

IDENTIFICATION OF CIS-ELEMENTS AND TRANSCRIPTION FACTORS THAT REGULATE THE TISSUE SPECIFIC EXPRESSION OF HSP47
Yasuda Kunihiko; Hirayoshi Kazunori; Hosokawa Nobuko; Nagata Kazuhiro
Connective tissue, Apr. 2002

Promoter Analysis of HSP47, a Collagen Specific Molecular Chaperone
HIRATA Hiromi; YAMAMURA Isao; HIRAYOSHI Kazunori; HOSOKAWA Nobuko; NAGATA Kazuhiro
日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

Cloning, expression, and characterization of EDEM homolog proteins
Y Natsuka; K Hirao; J Nakamura; S Natsuka; N Hosokawa; K Nagata
GLYCOBIOLOGY, Nov. 2004

小胞体シャペロンタンパク質SDF2L1の機能解析
田中雄大; 藤森力; 宮崎恵里; 花房賢; 寿野良二; 細川暢子
日本生化学会大会(Web), 2015

蛋白質の一生
徳永文稔; 門脇寿枝; 西頭英起; 内木宏延; 樋口京一; 中矢正; 鈴木利治; 後藤祐児; 船津高志; 金子清俊; 中戸川仁; 森和俊; 米田悦啓; 垣塚彰; 馬艶; 久野高義; 和田郁夫; 西川周一; 伊川正人; 吉田賢右; 遠藤斗志也; 永田和宏; 阿部哲也; 養王田正文; 金城政孝; 元島史尋; 田口英樹; 吉田祐美; 中村暢宏; 阪口雅郎; 小椋光; 森正敬; 稲葉謙次; 久保田広志; 森戸大介; 細川暢子; 大塚健三; 秋山芳展; 徳田元; 藤木幸夫
蛋白質核酸酵素, 10 Jun. 2008

Functional analysis of EDEM homologue protein
Yuko Natsuka; Kazuyoshi Hirao; Junji Nakamura; Taku Tamura; Ikuo Wada; Shunji Natsuka; Nobuko Hosokawa; Kazuhiro Nagata
CELL STRUCTURE AND FUNCTION, Jun. 2005

EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha 1-antitrypsin
Nobuko Hosokawa; Ikuo Wada; Yuko Natsuka; Kazuhiro Nagata
CELL STRUCTURE AND FUNCTION, May 2004

EDEM cooperates with calnexin in the ER associated degradation of unfolded proteins
Yukako Oda; Nobuko Hosokawa; Kazuhiro Nagata
EURESCO Conferences on Biology of Molecular Chaperones, 2003

Possible functions of EDEM in the ERAD of terminally misfolded proteins
Kazuhiro Nagata; Yukako Oda; Kazuyoshi Hirao; Nobuko Hosokawa
1st International Congress on Stress Responses in Biology and Medicine, 2003

ERADにおけるEDEMとcalnexinの機能解析
ODA YUKAKO; HOSOKAWA NOBUKO; WADA IKUO; NAGATA KAZUHIRO
日本細胞生物学会大会講演要旨集, 2003

ERAD 経路におけるEDEM-calnexin complex の解析
小田裕香子; 細川暢子; 和田郁夫; 永田和宏
第25回日本分子生物学会年会, 2002

Quality control of the nascent proteins in the endoplasmic reticulum
Kazuhiro Nagata; Yukako Oda; Nobuko Hosokawa
The 4th APOCB Congress, The Asian Pacific Organization for Cell Biology, 2002

ERAD経路においてEDEMと相互作用するタンパク質との解析
ODA YUKAKO; HOSOKAWA NOBUKO; WADA IKUO; NAGATA KAZUHIRO
日本細胞生物学会大会講演要旨集, 2002

新規小胞体α‐mannosidase様蛋白質(Mnl1p)は糖蛋白質の小胞体蛋白質分解(ERAD)に関与する
中務邦雄; 西川周一; 細川暢子; 永田和宏; 遠藤斗志也
日本細胞生物学会大会講演要旨集, 2001

HSP47の組織特異的発現は2つのシスエレメントにより制御されている
平田普三; 山村功; 安田邦彦; 小林明央; 多田昇弘; 鈴木操; 平芳一法; 細川暢子; 永田和宏
日本細胞生物学会大会講演要旨集, 1999

コラーゲン特異的分子シャペロンHSP47・ノックアウトマウスの解析
永井尚子; 糸原重美; 細川昌則; 細川暢子; 永田和宏
日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

コラーゲン特異的分子シャペロンHSP47のプロモーター解析
平田普三; 細川暢子; 永田和宏
日本細胞生物学会大会講演要旨集, 1997

糖タンパク質の品質管理－小胞体における糖鎖の「枝」の役割－
細川暢子
ポスター2 糖タンパク質の品質管理－小胞体における糖鎖の「枝」の役割－細川暢子（細胞機能調節学分野）「再生医学・再生医療の先端融合的共同研究拠点」平成24 年度学術講演会開催日：2012 年12 月19 日（水）, 2012, Peer-reviewed

Roles of N-glycans in the regulation of mammalian glycoprotein quality control.
Hosokawa N
第34 回日本分子生物学会年会シンポジウム “Glycoprotein quality control: Biosynthesis, molecular recognition and physiological roles of N-glycans”（ 2011.12.16 横浜）, 16 Dec. 2011, Peer-reviewed

The novel role of MRH domain-containing lectin \nXTP3-B in endoplasmic reticulum quality control
Fujimori T; Kamiya Y; Kato K; Nagata K; Hosokawa N
第34 回日本分子生物学会年会（2011.12.13-16 横浜）（口頭及びポスター発表）, 13 Dec. 2011, Peer-reviewed

Functional analysis of MRH domain-containing lectin \nXTP3-B in the endoplasmic reticulum quality control.
Fujimori T; Kamiya Y; Kato K; Nagata K; Hosokawa N
The 31st Naito Conference on Glycan Expression and Regulation [II] Metabolites, Stress response, Microdomains, and Beyond.（2011.9.13-16 Sapporo）（ポスター発表）, 2011, Peer-reviewed

Functional analysis of a \nmammalian lectin XTP3-B in the endoplasmic reticulum quality control
Tsutomu Fujimori; Yukiko Kamiya; Koichi Kato; Kazuhiro Nagata; Nobuko Hosokawa
The 3rd International Symposium on Protein Community，奈良市，2010.9.13－16, 2010, Peer-reviewed

Formation of HRD1-SEL1L ubiquitin ligase \ncomplex that regulates the mammalian ERAD
Nobuko Hosokawa; Yasutaka Iida; Katsuya Okawa; Kazuhiro Nagata
The 3rd International Symposium on Protein Community，奈良市，2010.9.13－16, 2010, Peer-reviewed

小胞体関連分解におけるHRD1-SEL1L ユビキチンリガーゼ複合体の機能
細川暢子
京都大学再生医科学研究所 \n「再生医学・再生医療の先端融合的共同研究拠点」 \n平成22 年度学術講演会 \n開催日：2010 年12 月13 日（月） \n場所：芝蘭会館稲盛ホール, 2010, Peer-reviewed

ヒト新規レクチンXTP3-B の機能解析
藤森力; 神谷由紀子; 加藤晃一; 永田和宏; 細川暢子
特定領域研究「タンパク質の社会」第3 回若手ワークショップ，宗像市，2010.07.1－3, 2010, Peer-reviewed

OS-9 and XTP3-B, the MRH Domain-Containing Lectins in Mammals are Involved in ERAD
Nobuko Hosokawa
GLYCOBIOLOGY, Nov. 2009, Peer-reviewed

タンパク質の品質管理機構
細川暢子
京都府立医科大学大学院医学研究科・免疫・微生物学セミナー，京都市， 2009.08.28, 2009, Peer-reviewed

小胞体関連分解に関わるHRD1-SEL1L複合体の安定性と機能
飯田恭崇; 細川暢子; 永田和宏
第82 回日本生化学会大会，神戸市，2009.10.21－24, 2009, Peer-reviewed

小胞体レクチンによる糖タンパク質の品質管理機構
細川暢子; 和田郁夫; 神谷由紀子; 加藤晃一; 永田和宏
第 61 回日本細胞生物学会大会，名古屋市，2009.06.02－04, 2009, Peer-reviewed

Quality control of proteins in the \nendoplasmic reticlum.
Nobuko Hosokawa; Ikuo Wada; Yukiko Kamiya; Koichi Kato; Kazuhiro Nagata
京都大学再生医科学研究所設立10周年記念国際シンポジウム，京都市，2008.12.4, 2008, Peer-reviewed

新規レクチンによる小胞体タンパク質品質管理機構
細川暢子; 和田郁夫; 長澤孝治; 森山達哉; 大川克也; 永田和宏
第31回日本分子生物学会年会・第81回日本生化学会大会合同大会一般口頭発表およびポスター発表，神戸市，2008.12.9-12, 2008, Peer-reviewed

Human XTP3- B forms an ER quality-control Scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP．
Nobuko Hosokawa; Ikuo Wada; Koji Nagasawa; Tetsuya Moriyama; Katsuya Okawa; Kazuhiro Nagata
特定領域研究「タンパク質の一生」ポストシンポジウム，熱海市，2007.11.22－23, 2007, Peer-reviewed

The clearance of misfolded CFTR mutant involves the ER membrane ubiquitin ligase, gp78.
Daisuke Morito; Kazuyoshi Hirao; Nobuko Hosokawa; Fuminori Tokunaga; Kazuhiro Nagata
2006 FASEB Summer Research Conferences Protein Folding in the Cell，Vermont （USA），2006.7.29－8.3, 2006, Peer-reviewed

小胞体膜貫通型ユビキチンリガーゼ gp78 のE4 活性による変異型CFTR のユビキチン化
森戸大介; 平尾和義; 細川暢子; 徳永文稔; 田中啓二; 岩井一宏; 永田和宏
第1 回臨床ストレス応答学会大会，京都市，2006.11.22 －23, 2006, Peer-reviewed

小胞体関連分解におけるユビキチンリガーゼの機能分担
森戸大介; 平尾和義; 細川暢子; 永田和宏
2005年度科学技術振興機構戦略的創造研究推進事業“たんぱく質関連領域”合同シンポジウム, 豊中市, 2005. 11. 15－16, 15 Nov. 2005, Peer-reviewed

EDEM3 たんぱく質は糖たんぱく質の分解を促進する
細川暢子; 平尾和義; 中村純治; 森戸大介; 長束優子; 和田郁夫; Pedro Romero; Barry Sleno; Linda O. Tremblay; Annette Herscovics; 永田和宏
2005 年度科学技術振興機構戦略的創造研究推進事業“たんぱく質関連領域”合同シンポジウム, 豊中市, 2005. 11. 15－16, 15 Nov. 2005, Peer-reviewed

Involvement of TRAP complex in ERAD pathway.
Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Kazuhiro Nagata
International Symposium on Life of Proteins, Awaji （Japan）, 2005. 10. 30－11. 3, 30 Oct. 2005, Peer-reviewed

小胞体膜蛋白質Herp はPNGase と結合し, 小胞関連分解基質の脱糖鎖を促進する
菊池唯史; 細川暢子; 永田和宏; 鈴木匡; 宮田敏行; 小亀浩市
第78 回日本生化学会ワークショップ「小胞体の蛋白質品質管理」, 神戸市, 2005. 10. 19, 19 Oct. 2005, Peer-reviewed

TRAP complex is involved in ERAD pathway
Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Kazuhiro Nagata
CELL STRUCTURE AND FUNCTION, Jun. 2005, Peer-reviewed

Dissection of functional differences between two mammalian Hrd1p orthologues: gp78 and mHRD1
Daisuke Morito; Kazuyoshi Hirao; Nobuko Hosokawa; Kazuhiro Nagata
CELL STRUCTURE AND FUNCTION, Jun. 2005, Peer-reviewed

EDEM 可溶性ホモログ EDEM3はマンノシダーゼ活性を介してERADを促進する
長束優子; 平尾和義; 中村純治; 田村拓; 和田郁夫; 長束俊治; 細川暢子; 永田和宏
第25回日本糖質学会年会, 大津市, 2005. 7. 20－22, 2005, Peer-reviewed

Alpha-mannosidase-like proteins accelerate glycoprotein ERAD \n基盤研究C 企画調査「タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読」
Nobuko Hosokawa
シンポジウム「Strategies for the acquirement of functional diversity of proteins タンパク質の多様性は限られたゲノム情報からいかにして生み出されるか？」, 東京都, 2005. 1. 20, 2005, Peer-reviewed

ER-associate degradation : EDEM, soluble EDEM and more...
Kazuhiro Nagata; Nobuko Hosokawa
The 1st Pacific- Rim International Conference on Protein Science（2004.4.16. Yokohama）, 2004, Peer-reviewed

A soluble homologue of EDEM accelerate ER-associated degradation
Kazuyoshi Hirao; Daisuke Morito; Yoko Natsuka; Nobuko Hosokawa; Yoshihide Hayashizaki; Kazuhiro Nagata
CELL STRUCTURE AND FUNCTION, May 2004, Peer-reviewed

Simultaneous induction of all subunits of TRAP gene by ER stress
Koji Nagasawa; Toshio Hijzashi; Nobuko Hosokawa; Kazuhiro Nagata
CELL STRUCTURE AND FUNCTION, May 2004, Peer-reviewed

Differential expression of EDEM and solEDEM (EDEM soluble homologue) mRNAs during embryonic development of the mice
Junji Nakamura; Kazuhiro Nagata; Nobuko Hosokawa
CELL STRUCTURE AND FUNCTION, May 2004, Peer-reviewed

糖タンパク質の小胞体関連分解：小胞体マンノシダーゼI, EDEM, EDEM ホモログタンパク質は，いずれも糖タンパク質のERAD を促進する
細川暢子; 平尾和義; 中村純治; 長束優子; 和田郁夫; 永田和宏
第77 回日本生化学会大会シンポジウム「糖タンパク質のフォールディングとプロセシングの品質管理」（2004.10.15. 横浜市）, 2004, Peer-reviewed

小胞体の品質管理機構－細胞内メカニズム－
細川暢子
千里ライフサイエンスセミナー「タンパク質のクオリティコントロールとその破綻」（2004.9.7. 豊中市）, 2004, Peer-reviewed

小胞体膜蛋白質Herp は小胞体関連分解基質の脱糖鎖と分解に関与する
菊池唯史; 細川暢子; 永田和宏; 宮田敏行; 小亀浩市
第27 回日本分子生物学会大会（2004.12.10. 神戸市）, 2004, Peer-reviewed

細胞周期依存的なER exit site のダイナミクス（Ⅱ）：ER－ゴルジ体小胞輸送への影響
山内忍; 加納ふみ; 近藤久雄; 田中亜路; 土田マーク彰; 細川暢子; 永田和宏; 村田昌之
第27 回日本分子生物学会大会（2004.12.9. 神戸市）, 2004, Peer-reviewed

哺乳類HRD1 ホモログの基質選択の解析
森戸大介; 平尾和義; 細川暢子; 永田和宏
第27 回日本分子生物学会大会（2004.12.9. 神戸市）, 2004, Peer-reviewed

EDEM ホモログ蛋白質の機能解析
長束優子; 平尾和義; 中村純治; 田村拓; 和田郁夫; 長束俊治; 細川暢子; 永田和宏
第77 回日本生化学会大会（2004.10.15. 横浜市）, 2004, Peer-reviewed

糖タンパク質の小胞体関連分解に関わるマンノシダーゼ様タンパク質
細川暢子; 平尾和義; 中村純治; 長束優子; 和田郁夫; 永田和宏
文部科学省特定領域研究「糖鎖によるタンパク質と分子複合体の機能調節」夏期シンポジウム（2004.8.26～27. 木更津市）, 2004, Peer-reviewed

Presentations

ERp46 triggers mannose trimming activity of EDEM3.
HOSOKAWA Nobuko
International Symposium on ER stress, glycosylation, homeostasis and diseases, 22 Mar. 2018, Invited

小胞体関連分解を担うHRD1-SEL1Lユビキチンリガーゼ複合体の機能解析
細川暢子
第34回日本糖質学会年会, 01 Aug. 2015, Invited

小胞体膜におけるプロテオスタシス維持機構
第36回日本分子生物学会年会ワークショップ「ER・Post-ERにおける膜プロテオスタシスネットワーク研究の新展開」, 05 Dec. 2013, 日本分子生物学会

Homeostasis and quality control of proteins in cells
The Joint Symposium of the 7th International Symposium of the Institute Network and the 45th IDAC Symposium, the 2nd Symposium for Joint Usage/Research Center of Aging. “Research Frontiers for Smart Aging” （仙台市）, 15 Jun. 2012, The 7th International Symposium of the Institute Network

Roles of N-glycans in the regulation of mammalian glycoprotein quality control
第34回日本分子生物学会年会回日本分子生物学会年会シンポジウム｢Glycoprotein quality control: Biosynthesis, moelecular recognition and physiological roles of N-glycans｣, 16 Dec. 2011, 日本分子生物学会

小胞体における糖鎖修飾とタンパク質品質管理機構
第84回日本生化学会大会シンポジウム「糖鎖修飾：システムズバイオロジーへの展望」, 22 Sep. 2011, 日本生化学会

Lectins and enzymes that regulate the mammalian glycoprotein quality control
Glycan Expression and Regulation [II] Metabolites, Stress response, Microdomains, and Beyond, 14 Sep. 2011, The 31st Naito Conference

OS-9 and XTP3-B, the MRH Domain-containing Lectins in Mammals are Involved in ERAD
Annual Conference of the Society for Glycobiology, 15 Nov. 2009, The Society for Glycobiology

新規小胞体レクチンによる糖タンパク質の品質管理機構
第6回糖鎖科学コンソーシアムシンポジウム, 03 Dec. 2008, 糖鎖科学コンソーシアム

小胞体関連分解を促進するEDEMファミリータンパク質の機能解析
文部科学省特定領域研究「糖鎖によるタンパク質と分子複合体の機能調節」第4回公開シンポジウム, 31 Jan. 2006, 文部科学省特定領域研究「糖鎖によるタンパク質と分子複合体の機能調節」

小胞体の品質管理機構
第７回GGA-HSP勉強会, 27 Aug. 2005

α-Mannosidase-like proteins accelerate glycoprotein ERAD
基盤研究Ｃ企画調査「タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読」シンポジウム「Strategies for the acquirement of functional diversity of proteins タンパク質の多様性は限られたゲノム情報からいかにして生み出されるか？」, 20 Jan. 2005, 基盤研究Ｃ企画調査「タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読」

α-Mannosidase-like proteins involved in glycoprotein ERAD
第27回日本分子生物学会年会ワークショップ｢タンパク質の品質管理とその破綻｣, 04 Dec. 2004, 日本分子生物学会

糖タンパク質の小胞体関連分解：小胞体マンノシダーゼI、EDEM、EDEMホモログタンパク質は、いずれも糖タンパク質のERADを促進する
第77回日本生化学会大会シンポジウム「糖タンパク質のフォールディングとプロセシングの品質管理」, 15 Oct. 2004, 日本生化学会

小胞体の品質管理機構−細胞内メカニズム−
千里ライフサイエンスセミナー「タンパク質のクオリティコントロールとその破綻」, 07 Sep. 2004, 千里ライフサイエンスセミナー

ER Degradation of Glycoproteins
第26回日本分子生物学会年会シンポジウム「糖鎖細胞生物学の新展開−”あいまいさ”を越えて−, 11 Dec. 2003, 日本分子生物学会

糖タンパク質の小胞体関連分解
平成15年度生化学会近畿支部シンポジウム「細胞内品質管理のダイナミズム」, 21 Nov. 2003, 生化学会近畿支部

小胞体品質管理に関わるEDEM 蛋白質の機能解析
第56回日本細胞生物学会大会ワークショップ「タンパク質：生と死の生物学」, 16 May 2003, 日本細胞生物学会

小胞体関連分解におけるEDEM 蛋白質の機能
第25 回日本分子生物学会年会ワークショップ, 11 Dec. 2002, 日本分子生物学会

糖蛋白質の小胞体関連分解
第7回病態と治療におけるプロテアーゼとインヒビター研究会, 16 Aug. 2002, 病態と治療におけるプロテアーゼとインヒビター研究会

小胞体関連分解(ERAD)に関与する、EDEM 蛋白質の機能解析
第55回日本細胞生物学会大会ワークショップ, 21 May 2002, 日本細胞生物学会

細胞環境を創るストレスタンパク質：コラーゲン特異的分子シャペロンHSP47 による細胞機能制御
文部省基盤C シンポジウム「脳の形成」と「生活習慣病予防」に運動が必要なわけを探る, 01 Mar. 2002, 文部省基盤C シンポジウム

小胞体ストレスと小胞体関連分解
千里ライフサイエンスセミナー, 14 Dec. 2001, 千里ライフサイエンスセミナー

小胞体関連分解“シグナル”認識機構
第７４回日本生化学会大会シンポジウム, 28 Oct. 2001, 日本生化学会

A novel ER α-mannosidase-like protein accelerates ER-associated degradation.
8th CGGH Symposium "New Paradigms of Molecular Chaperones in the Postgenome Era", 07 Aug. 2001

小胞体関連分解(ERAD) を促進するα-mannosidase 様蛋白質の機能解析
第73回日本生化学会大会シンポジウム, 11 Oct. 2000, 日本生化学会

フラボノイドによる熱ショック蛋白質誘導の阻害
Japanese Society for Food Factors シンポジウム, 10 Dec. 1996, Japanese Society for Food Factors

Books and Other Publications

ERAD（小胞体関連分解）を制御するレクチンOS-9とXTP3-B.
細川暢子
日本生化学会, 2011, Not refereed

N.: Isolation and binding assay of EDEMs
Hosokawa N, Single work
GlycoPOD web site（Ed. T. Kawasaki）: <9>-9（2011）, 2011, Not refereed

Mannose 6-phosphate receptor homology domain-containing lectins in mammalian endoplasmic reticulum-associated degradation.
Hosokawa N; Kato K; Kamiya Y
Methods in Enzymology: 480 (Ed. M. Fukuda) Elsevier, 181-197, 2010, Not refereed

M-type lectins as novel components of secretory pathways.
Hosokawa N; Nagata K
“Animal Lectins: A Functional View” (Eds. G. R. Vasta, H. Ahmed) CRC Press, 165-169, 2009, Not refereed

キーワード：タンパク質の一生 (編集：遠藤斗志也、小椋光、永田和宏、田口英樹、吉田賢右)
細川暢子
蛋白質核酸酵素 Vol. 53, No.8、分担, 2008, Not refereed

Degradation of misfolded glycoproteins in the endoplasmic reticulum.
Hosokawa N
“Experimental Glycoscience Glycobiology” (Eds. N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki, S. Hase) Springer, 207-210, 2008, Not refereed

小胞体関連分解におけるEDEMファミリータンパク質の機能．
長束優子; 細川暢子; 永田和宏
実験医学「細胞内タンパク質の社会学」（永田和宏、遠藤斗志也編）Vol.23, No.15: 2352-2357, 2005, Not refereed

小胞体におけるミスフォールドタンパク質の分解機構
細川暢子
未来を拓く糖鎖科学 (監修永井克孝):263-264, 2005, Not refereed

小胞体タンパク質の品質を保証する細胞内メカニズム．
細川暢子
日本農芸化学会, 2005, Not refereed

小胞体関連分解(ERAD)
細川暢子
生体の科学Vol.55, No.5: 416-417, 2004, Not refereed

小胞体タンパク質品質管理とERAD-EDEM分子は糖タンパク質のERADを促進する.
細川暢子
蛋白質核酸酵素「細胞における蛋白質の一生」Vol.49, No.7: 984-987, 2004, Not refereed

小胞体でつくられたタンパク質の運命
細川暢子; 永田和宏
実験医学Vol.21, No.7: 細胞内タンパク質の運命」, 892-897, 2003, Not refereed

ERADによる品質管理機構
細川暢子; 永田和宏
日本生化学会, 2003, Not refereed

小胞体関連分解(ERAD)（小胞体蛋白質分解系）
細川暢子
初耳辞典, 2003, Not refereed

小胞体ストレスと小胞体関連分解
細川暢子; 永田和宏
「特集1 小胞体ストレスと神経細胞死」脳21 金宝堂 Vol.5, No. 2: 126-129, 2002, Not refereed

Involvement of HSP47 in the Folding and Processing of Procollagen in the Endoplasmic Reticulum.
Nagata K; Satoh M; Hosokawa N; Miller A.D
Molecular Chaperones in the Life Cycle of Proteins,, 1997, Not refereed

External funds: Kakenhi

Study on the intracellular transsport mechanism of collagens
Grant-in-Aid for Scientific Research (C)
Basic Section 44010:Cell biology-related
Kyoto University
Nobuko Hosokawa
From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
コラーゲン;細胞内輸送;小胞体;ゴルジ装置;蛍光タンパク質;小胞輸送;ライブセルイメージング;ライブイメージング;哺乳類細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06214/

Study on the protein quality control mechanism in the endoplasmic reticulum
Grant-in-Aid for Scientific Research (C)
Kyoto University
Nobuko Hosokawa
From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
小胞体;タンパク質品質管理;シャペロンタンパク質;タンパク質分解;小胞体関連分解;動物細胞;糖タンパク質;マンノシダーゼ;ユビキチンリガーゼ複合体
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26440096/

Analysis of the ubiquitin-ligase complex in the endoplasmic reticulum membrane that regulates endoplasmic reticulum-associated degradation in mammals
Grant-in-Aid for Scientific Research (C)
Kyoto University
Nobuko HOSOKAWA
From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
小胞体;小胞体関連分解;ユビキチンリガーゼ;タンパク質品質管理;HRD1-SEL1L複合体;レクチン;タンパク質;ユビキチンプロテアソーム系;糖鎖;タンパク質分解;分子細胞生物学;HRD1-SEL1L
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22570183/

レクチンとシャペロンを介した小胞体タンパク質の品質管理
Grant-in-Aid for Scientific Research on Priority Areas
Biological Sciences
Kyoto University
細川暢子
Project Closed
タンパク質品質管理;分子シャペロンタンパク質;レクチン;小胞体;小胞体関連分解
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22020020/

Quality control mechanism of misfolded proteins
Grant-in-Aid for Creative Scientific Research
Kyoto Sangyo University;Kyoto University
Kazuhiro NAGATA
Project Closed
品質管理;フォールディング;レドックス;小胞体;小胞体品質管理;ジスルフィド結合;EDEM;ERdj5;分子シャペロン
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19GS0314/

ユビキチンリガーゼ複合体による小胞体関連タンパク質分解機構の研究
Grant-in-Aid for Scientific Research on Priority Areas
Biological Sciences
Kyoto University
細川暢子
Project Closed
小胞体タンパク質分解;ユビキチンリガーゼ;小胞体品質管理;糖タンパク質;小胞体;小胞体シャペロンタンパク質
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19044022/

Analysis of the molecular mechanism ofendoplasmic reticulum-associated protein degradation (ERAD)
Grant-in-Aid for Scientific Research (C)
Kyoto University
Nobuko HOSOKAWA
Project Closed
小胞体;小胞体関連分解;品質管理;細胞内輸送;糖タンパク;分子シャペロン;糖タンパク質, endoplasmic reticulum (ER);ER-associated protein degradation (ERAD);ER quality control (ERQC);intracellular transport;glycoprotein;molecular chaperone
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17570161/

糖タンパク質の小胞体品質管理機構
Grant-in-Aid for Scientific Research on Priority Areas
Biological Sciences
Kyoto University
細川暢子
Project Closed
N結合型糖鎖;糖タンパク質;小胞体品質管理;α-マンノシダーゼ;小胞体関連分解
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17046009/

Quality control mechanism for positive and negative
Grant-in-Aid for Scientific Research (A)
Kyoto University
Kazuhiro NAGATA
Project Closed
分子シャペロン;品質管理;小胞体関連分解;EDEM, Molecular Chaperone;Quality control;ER associated degradation;EDEM
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16207013/

Functional analysis of EDEM which accelerates glycoprotein ERAD
Grant-in-Aid for Scientific Research (C)
KYOTO UNIVERSITY
Nobuko HOSOKAWA
Project Closed
小胞体関連分解;小胞体品質管理;小胞体;糖タンパク質;小胞体シャペロンタンパク質;小胞体ストレス;α-マンノシダーゼ;小胞体マンノシターゼI, ERAD(ER associated degradation);ER quality control;ER(endoplasmic reticulum);glycoproteins;ER chaperone proteins;ER stress;α-mannosidase
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15570157/

糖鎖による蛋白質の小胞体品質管理機構の解析
Grant-in-Aid for Scientific Research on Priority Areas
Biological Sciences
Kyoto University
細川暢子
Project Closed
N結合型糖鎖;糖タンパク質;小胞体品質管理;α-マンノシダーゼ;小胞体関連分野;N型糖鎖;小胞体マンノシダーゼI;小胞体関連分解
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15040213/

Molecular mechanism of ER-related degradation
Grant-in-Aid for Scientific Research on Priority Areas
Biological Sciences
Kyoto University
Kazuhiro NAGATA
Project Closed
分子シャペロン;品質管理;小胞体関連分解;EDEM;小胞体関連分野;分子シヤペロン, Molecular Chaperone;Quality control;ER associated degradation;EDEM
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14037230/

Funcioal analysis of mouse EDEM, which eaocelerales gyocprotein ERAD
Grant-in-Aid for Scientific Research (C)
KYOTO UNIVERSITY
Nobuko HOSOKAWA
Project Closed
小胞体関連分解;品質管理機構;糖タンパク質;小胞体マンノシダーゼ;小胞体;糖蛋白質;小胞体マンノンダーゼ, ERAD(ER associated degadation);ER quality control;Glyooprotein;ER marnosidase I;ER(endoplasmicreticulun)
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680780/

コラーゲン特異的分予シャペロンHSP47の構造と機能
Grant-in-Aid for Scientific Research (B)
Kyoto University
永田和宏
Project Closed
HSP47;コラーゲン;semi-permeabilized cell;ノックアウトマウス;分子シャペロン;結晶解析
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11694271/

A Search for a new chaperone proteins on the endoplasmic retical
Grant-in-Aid for Scientific Research (C)
KYOTO UNIVERSITY
Nobuko HOSOKAWA
Project Closed
小胞体;小胞体関連分解;α-マンノシダーゼ;小胞体の品質管理機構;糖蛋白質;小胞体関係連分解;分子シャペロン;品質管理機構;小胞体関連蛋白質分解, Endoplasmic Reticulum;ERADC Endoplasmic reticulum associated degradation;d-Mannosidase;Quality Control of the Endoplasmic Reticulum;Glycoprotein
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680695/

コラーゲン特異的分子シャペロンによる癌細胞の浸潤転移制御
Grant-in-Aid for Scientific Research on Priority Areas
Kyoto University
永田和宏
Project Closed
ストレス蛋白質;HSP47;プロコラーゲン;分子シャペロン
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08265230/

The role of collagen-specific molecular chaperone HSP47
Grant-in-Aid for international Scientific Research
KYOTO UNIVERSITY
Kazuhiro NAGATA
Project Closed
ストレス蛋白質;HSP47;プロコラーゲン;分子シャペロン;コラーゲン;細胞内輸送, stress protein;HSP47;procollagen;molecular chaperone
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06044125/

External funds: others

糖タンパク質の小胞体品質管理機構の解明
上原記念生命科学財団研究助成金
From 2007, To 2007
細川暢子

小胞体関連分解を担うEDEMファミリータンパク質の機能解析
公益信託林女性自然科学者研究助成基金
From 2009, To 2010
細川暢子

Functional analysis of N-glycans on the quality control of proteins
水谷糖質科学振興財団
From 2012, To 2012
細川暢子

小胞体ストレスによって神経細胞特異的に発現誘導を受ける遺伝子群の解析
第34回内藤記念科学奨励金（研究助成）
From 2012, To 2012
細川暢子

Last Updated :2022/08/06

Education

Teaching subject(s)

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IIC
9125, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IB
9120, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IID
9126, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology ID
9122, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IIB
9124, Fall, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IA
9119, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IC
9121, Spring, Graduate School of Science, 1

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Course on Biological Science A
9011, Spring, Graduate School of Science, 2

From 01 Apr. 2022, To 31 Mar. 2023
Seminar on Molecular and Cellular Biology IIA
9123, Spring, Graduate School of Science, 1

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅠＡ
Spring, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅠB
Fall, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅠC
Spring, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅠD
Fall, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅡＡ
Spring, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅡB
Fall, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅡC
Spring, 理学研究科

From Apr. 2011, To Mar. 2012
分子細胞生物学ゼミナールⅡD
Fall, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2014, To Mar. 2015
Seminar on Developmental Biology and Regenerative Medicine
Spring, 全学共通科目

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2015, To Mar. 2016
Seminar on Developmental Biology and Regenerative Medicine
Spring, 全学共通科目

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2016, To Mar. 2017
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2017, To Mar. 2018
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2018, To Mar. 2019
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
ILAS Seminar
Spring, 全学共通科目

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2019, To Mar. 2020
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2020, To Mar. 2021
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2020, To Mar. 2021
Advanced Course on Biological Science A
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IA
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IB
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IC
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology ID
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IIA
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IIB
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IIC
Spring, 理学研究科

From Apr. 2021, To Mar. 2022
Seminar on Molecular and Cellular Biology IID
Fall, 理学研究科

From Apr. 2021, To Mar. 2022
Advanced Course on Biological Science A
Spring, 理学研究科

Participation in PhD Defense

SEL1Lの分解中間体はポリグルタミンタンパク質の細胞質での凝集を促進する
HATTORI TOKUYA, Graduate School of Science, Chief Examiner
24 Jan. 2022

Last Updated :2022/08/06

Administration

School management (title, position)

From 01 Apr. 2009, To 31 Mar. 2010
組換えDNA実験安全委員会委員

From 01 Feb. 2018, To 31 Mar. 2020
衛生管理者

Faculty management (title, position)

From 01 Apr. 2021
安全衛生委員会　委員

From 01 Jul. 2021
再生実験動物施設飼育室施設運営委員会委員

From 01 Apr. 2016, To 31 Mar. 2018
将来計画・評価員会委員

From 01 Apr. 2016, To 31 Mar. 2018
予算委員会委員

From 01 Oct. 2016, To 30 Jun. 2021
再生医科学動物実験専門委員会　委員

From 01 Oct. 2016
（旧再生研）予算委員会　委員

From 01 Apr. 2018, To 31 Mar. 2020
安全衛生委員会

人権委員会　委員

動物実験委員会　委員

放射線障害防止委員会

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