Basic Information

Affiliated programs (koza)

• Graduate School of Science, 生物科学専攻 生物物理学（分子細胞生物学）, 准教授
• Graduate School of Medicine, 医学専攻 細胞機能調節学, 准教授
• Graduate School of Medicine, 医科学専攻 細胞機能調節学, 准教授

Professional Memberships

• 日本生化学会
• 日本分子生物学会
• 日本細胞生物学会

Academic Degree

• 博士（医学）(京都府立医科大学)

Academic Resume (Graduate Schools)

• 京都府立医科大学大学院, 医学研究科博士課程, 社会医学系, 単位取得退学

Academic Resume (Undergraduate School/Majors)

• 京都府立医科大学, 医学部医学科, 卒業
• 京都府立医科大学, 医学部医学進学課程, 修了

High School

• High School

  奈良女子大学文学部附属高等学校

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-8584-6966

• J-Global ID

  200901063396558394

researchmap URL

• https://researchmap.jp/HOSOKAWA_Nobuko

Research

Research Topics, Overview of the research

• Research Topics

  Research on the quality control mechanism of proteins

• Overview of the research

  Newly synthesized polypeptides acquire their native conformations to be functional, and proteins that failed to fold properly or that are misfolded due to cellular stresses are degraded within the cells. This system is called as the quality control mechanism of proteins. I study the cellular mechanism of the protein quality control.

Research Interests

• 生化学
• 分子生物学
• 細胞生物学
• Biochemistry
• Molecular Biology
• Cell Biology

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Cell biology
• Life sciences, Molecular biology

Papers

• Endoplasmic reticulum–to–Golgi trafficking of procollagen III via conventional vesicular and tubular carriers

  Yukihiro Hirata; Yuto Matsui; Ikuo Wada; Nobuko Hosokawa

  Molecular Biology of the Cell, 01 Mar. 2022, Peer-reviewed

  
• Reconstitution of cell cycle-dependent morphological chanbes of the endoplasmic reticulum in semi-intact CHO cells

  Murata M.; Kano F.; Kondo H.; Hosokawa N.; Nagata K.

  Seibutsu Butsuri, 2001

  
• SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine‐expanded protein

  Tokuya Hattori; Ken Hanafusa; Ikuo Wada; Nobuko Hosokawa

  The FEBS Journal, 02 Mar. 2021, Peer-reviewed, Corresponding author

  
• Visualization of procollagen IV reveals ER-to-Golgi transport by ERGIC-independent carriers.

  Matsui Y; Hirata Y; Wada I; Hosokawa N

  Cell Structure and Function, 2020, Peer-reviewed, Last author, Corresponding author

  
• In vitro Mannosidase Assay of EDEMs: ER Degradation-Enhancing α-Mannosidase-Like Proteins

  HOSOKAWA Nobuko

  Lectin Purification and Analysis: Methods and Protocols, 2020, Invited

  
• SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein.

  Hanafusa K; Wada I; Hosokawa N

  Journal of Biological Chemistry, 2019, Peer-reviewed, Last author, Corresponding author

  
• ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation–enhancing α-mannosidase–like protein 3 (EDEM3)

  YU Shangyu; ITO Shinji; WADA Ikuo; HOSOKAWA Nobuko

  Journal of Biological Chemistry, 2018, Peer-reviewed

  
• Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation

  Tsutomu Fujimori; Ryoji Suno; Shun-Ichiro Iemura; Tohru Natsume; Ikuo Wada; Nobuko Hosokawa

  GENES TO CELLS, Aug. 2017, Peer-reviewed

  
• Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L

  Nobuko Hosokawa; Ikuo Wada

  FEBS JOURNAL, Jan. 2016, Peer-reviewed

  
• N-glycans and Quality control of proteins.

  HOSOKAWA Nobuko; SUZUKI Takashi

  “Sugar Chains. Decoding the Function of Glycans” (Eds. T. Suzuki, K. Ohtsubo, N. Taniguchi), 2015, Invited

  
• Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded alpha 1-antitrypsin variant

  Tsutomu Fujimori; Yukiko Kamiya; Kazuhiro Nagata; Koichi Kato; Nobuko Hosokawa

  FEBS JOURNAL, Mar. 2013, Peer-reviewed

  
• Assay for endoplasmic reticulum-associated degradation (ERAD) in mammalian cells.

  Hosokawa N

  GlycoPOD web site : Biosynthesis & Metabolism (Ed. T. Kawasaki) (2012), 2012, Peer-reviewed

  
• SEL1L Protein Critically Determines the Stability of the HRD1-SEL1L Endoplasmic Reticulum-associated Degradation (ERAD) Complex to Optimize the Degradation Kinetics of ERAD Substrates

  Yasutaka Iida; Tsutomu Fujimori; Katsuya Okawa; Kazuhiro Nagata; Ikuo Wada; Nobuko Hosokawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2011, Peer-reviewed

  
• [要修正] ERAD(小胞体関連分解)を制御するレクチンOS-9とXTP3-B

  細川暢子

  生化學, 25 Jan. 2011, Peer-reviewed

  
• OS-9 and XTP3-B: Lectins that regulate endoplasmic reticulum-associated degradation (ERAD)

  Nobuko Hosokawa

  Seikagaku, 2011, Peer-reviewed

  
• The role of MRH domain-containing lectins in ERAD

  Nobuko Hosokawa; Yukiko Kamiya; Koichi Kato

  GLYCOBIOLOGY, Jun. 2010, Peer-reviewed

  
• EDEM1 accelerates the trimming of alpha 1,2-linked mannose on the C branch of N-glycans

  Nobuko Hosokawa; Linda O. Tremblay; Barry Sleno; Yukiko Kamiya; Ikuo Wada; Kazuhiro Nagata; Koichi Kato; Annette Herscovics

  GLYCOBIOLOGY, May 2010, Peer-reviewed

  
• MANNOSE 6-PHOSPHATE RECEPTOR HOMOLOGY DOMAIN-CONTAINING LECTINS IN MAMMALIAN ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION

  Nobuko Hosokawa; Koichi Kato; Yukiko Kamiya

  METHODS IN ENZYMOLOGY, VOL 480: GLYCOBIOLOGY, 2010, Invited

  
• Human OS-9, a Lectin Required for Glycoprotein Endoplasmic Reticulum-associated Degradation, Recognizes Mannose-trimmed N-Glycans

  Nobuko Hosokawa; Yukiko Kamiya; Daiki Kamiya; Koichi Kato; Kazuhiro Nagata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2009, Peer-reviewed

  
• ANIMAL LECTINS A Functional View

  N. Hosokawa; K. Nagata

  M-type lectins as novel components of secretory pathways, (Eds Gerardo R.Vasta, Hafiz Ahmed) CRC Press pp. 165－169（2009）, 2009, Peer-reviewed

  
• Targeted disruption of Hsp110/105 gene protects against ischemic stress

  Junji Nakamura; Motoaki Fujimoto; Kunihiko Yasuda; Kiyoshi Takeda; Shizuo Akira; Takumi Hatayama; Yasushi Takagi; Kazuhiko Nozaki; Nobuko Hosokawa; Kazuhiro Nagata

  STROKE, Oct. 2008, Peer-reviewed

  
• Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

  Nobuko Hosokawa; Ikuo Wada; Koji Nagasawa; Tatsuya Moriyama; Katsuya Okawa; Kazuhiro Nagata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2008, Peer-reviewed

  
• Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508

  Daisuke Morito; Kazuyoshi Hirao; Yukako Oda; Nobuko Hosokawa; Fuminori Tokunaga; Douglas M. Cyr; Keiji Tanaka; Kazuhiro Iwai; Kazuhiro Nagata

  MOLECULAR BIOLOGY OF THE CELL, Apr. 2008, Peer-reviewed

  
• Degradation of misfolded plycoproteins in the endoplasmic reticulum

  N. Hosokawa

  "Experimental Glycoscience : Glycology" (Eds N. Taniguchin et al.) Springer pp. 207-210 (2008), 2008, Peer-reviewed

  
• Stimulation of ERAD of misfolded null Hong Kong alpha 1-antitrypsin by golgi alpha 1,2-mannosidases

  Nobuko Hosokawa; Zhipeng You; Linda O. Tremblay; Kazuhiro Nagata; Annette Herscovics

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2007, Peer-reviewed

  
• Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation

  Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Randal J. Kaufman; Kazuhiro Nagata

  EMBO REPORTS, May 2007, Peer-reviewed

  
• EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha 1-antitrypsin

  N Hosokawa; Wada, I; Y Natsuka; K Nagata

  GENES TO CELLS, May 2006, Peer-reviewed

  
• EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

  K Hirao; Y Natsuka; T Tamura; Wada, I; D Morito; S Natsuka; P Romero; B Sleno; LO Tremblay; A Herscovics; K Nagata; N Hosokawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2006, Peer-reviewed

  
• NSF/SNAPs and p97/p47/VCIP135 are sequentially required for cell cycle-dependent reformation of the ER network

  F Kano; H Kondo; A Yamamoto; Y Kaneko; K Uchiyama; N Hosokawa; K Nagata; M Murata

  GENES TO CELLS, Oct. 2005, Peer-reviewed

  
• [要修正] 小胞体タンパク質の品質を保証する細胞内メカニズム

  細川暢子

  化学と生物, Sep. 2005, Peer-reviewed

  
• The maintenance of the endoplasmic reticulum network is regulated by p47, a cofactor of p97, through phosphorylation by cdc2 kinase

  F Kano; H Kondo; A Yamamoto; AR Tanaka; N Hosokawa; K Nagata; M Murata

  GENES TO CELLS, Apr. 2005, Peer-reviewed

  
• [要修正] 胞体関連分解におけるEDEM ファミリータンパク質の機能

  長束優子; 細川暢子; 永田和宏

  実験医学「細胞 内タンパク質の社会学」（永田和宏，遠藤斗志也編）Vol. 23, No. 15 : 2352－2357(2005), 2005, Peer-reviewed

  
• Insufficient folding of type IV collagen and formation of abnormal basement membrane-like structure in embryoid bodies derived from Hsp47-null embryonic stem cells

  Y Matsuoka; H Kubota; E Adachi; N Nagai; T Marutani; N Hosokawa; K Nagata

  MOLECULAR BIOLOGY OF THE CELL, Oct. 2004, Peer-reviewed

  
• [要修正] ER quality control and ERAD: EDEM accelerates glycoprotein ERAD

  N. Hosokawa

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2004, Peer-reviewed

  
• [要修正] 小胞体タンパク質品質管理とERAD－EDEM 分子は糖タンパク質のERAD を促進する

  細川暢子

  蛋白質核酸酵素「細胞における蛋白質の一生」Vol.49,No.7 : 984－987（2004）, 2004, Peer-reviewed

  
• Enhancement of endoplasmic reticulum (ER) degradation of misfolded null Hong Kong alpha(1)-antitrypsin by human ER mannosidase I

  N Hosokawa; LO Tremblay; ZP You; A Herscovics; Wada, I; K Nagata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2003, Peer-reviewed

  
• ER quality control and ERAD

  HOSOKAWA Nobuko; NAGATA Kazuhiro

  生化学, 25 Jun. 2003, Peer-reviewed

  
• EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

  Y Oda; N Hosokawa; Wada, I; K Nagata

  SCIENCE, Feb. 2003, Peer-reviewed

  
• A time-dependent phase shift in the mammalian unfolded protein response

  H Yoshida; T Matsui; N Hosokawa; RJ Kaufman; K Nagata; K Mori

  DEVELOPMENTAL CELL, Feb. 2003, Peer-reviewed

  
• The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chaperone

  K Yasuda; K Hirayoshi; H Hirata; H Kubota; N Hosokawa; K Nagata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2002, Peer-reviewed

  
• Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary

  K Sato; K Yomogida; T Wada; T Yorihuzi; Y Nishimune; N Hosokawa; K Nagata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

  
• Heat shock protein (HSP) 47 and collagen are upregulated during neointimal formation in the balloon-injured rat carotid artery

  S Murakami; Y Toda; T Seki; E Munetomo; Y Kondo; T Sakurai; Y Furukawa; M Matsuyama; T Nagate; N Hosokawa; K Nagata

  ATHEROSCLEROSIS, Aug. 2001, Peer-reviewed

  
• A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation

  N Hosokawa; Wada, I; K Hasegawa; T Yorihuzi; LO Tremblay; A Herscovics; K Nagata

  EMBO REPORTS, May 2001, Peer-reviewed

  
• Mnl1p, an alpha-mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins

  K Nakatsukasa; S Nishikawa; N Hosokawa; K Nagata; T Endo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2001, Peer-reviewed

  
• Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid

  M Naitoh; N Hosokawa; H Kubota; T Tanaka; H Shirane; M Sawada; Y Nishimura; K Nagata

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2001, Peer-reviewed

  
• Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences

  M Matsuda; T Koide; T Yorihuzi; N Hosokawa; K Nagata

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2001, Peer-reviewed

  
• Embryonic lethality of molecular chaperone Hsp47 knockout mice is associated with defects in collagen biosynthesis

  N Nagai; M Hosokawa; S Itohara; E Adachi; T Matsushita; N Hokawa; K Nagata

  JOURNAL OF CELL BIOLOGY, Sep. 2000, Peer-reviewed

  
• Procollagen binds to both prolyl 4-hydroxylase/protein disulfide isomerase and HSP47 within the endoplasmic reticulum in the absence of ascorbate

  N Hosokawa; K Nagata

  FEBS LETTERS, Jan. 2000, Peer-reviewed

  
• Separate cis-acting DNA elements control cell type- and tissue-specific expression of collagen binding molecular chaperone HSP47

  H Hirata; Yamamura, I; K Yasuda; A Kobayashi; N Tada; M Suzuki; K Hirayoshi; N Hosokawa; K Nagata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1999, Peer-reviewed

  
• The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)

  N Nagai; Y Tetuya; N Hosokawa; K Nagata

  GENE, Feb. 1999, Peer-reviewed

  
• Expression and localization of collagen-binding stress protein Hsp47 in mouse embryo development: comparison with types I and II collagen

  H Masuda; N Hosokawa; K Nagata

  CELL STRESS & CHAPERONES, Dec. 1998, Peer-reviewed

  
• HSP47, a collagen-specific molecular chaperone, delays the secretion of type III procollagen transfected in human embryonic kidney cell line 293: A possible role for HSP47 in collagen modification

  N Hosokawa; C Hohenadl; M Satoh; K Kuhn; K Nagata

  JOURNAL OF BIOCHEMISTRY, Sep. 1998, Peer-reviewed

  
• Transcriptional activation of the mouse HSP47 gene in mouse osteoblast MC3T3-E1 cells by TGF-beta 1

  Yamamura, I; H Hirata; N Hosokawa; K Nagata

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 1998, Peer-reviewed

  
• Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen

  M Satoh; K Hirayoshi; SI Yokota; N Hosokawa; K Nagata

  JOURNAL OF CELL BIOLOGY, Apr. 1996, Peer-reviewed

  
• Regulation and function of collagen-specific molecular chaperone, HSP47

  Kazuhiro Nagata; Nobuko Hosokawa

  Cell Structure and Function, 1996, Peer-reviewed

  
• ALTERNATIVE 5' SPLICE-SITE SELECTION INDUCED BY HEAT-SHOCK

  H TAKECHI; N HOSOKAWA; K HIRAYOSHI; K NAGATA

  MOLECULAR AND CELLULAR BIOLOGY, Jan. 1994, Peer-reviewed

  
• STRUCTURE OF THE GENE ENCODING THE MOUSE 47-KDA HEAT-SHOCK PROTEIN (HSP47)

  N HOSOKAWA; H TAKECHI; S YOKOTA; K HIRAYOSHI; K NAGATA

  GENE, Apr. 1993, Peer-reviewed

  
• QUERCETIN, AN INHIBITOR OF HEAT-SHOCK PROTEIN-SYNTHESIS, INHIBITS THE ACQUISITION OF THERMOTOLERANCE IN A HUMAN COLON-CARCINOMA CELL-LINE

  M KOISHI; N HOSOKAWA; M SATO; A NAKAI; K HIRAYOSHI; M HIRAOKA; M ABE; K NAGATA

  JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1992, Peer-reviewed

  
• INHIBITION OF THE ACTIVATION OF HEAT-SHOCK FACTOR INVIVO AND INVITRO BY FLAVONOIDS

  N HOSOKAWA; K HIRAYOSHI; H KUDO; H TAKECHI; A AOIKE; K KAWAI; K NAGATA

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 1992, Peer-reviewed

  
• QUERCETIN, A BIOFLAVONOID, INHIBITS THE INCREASE OF HUMAN MULTIDRUG RESISTANCE GENE (MDR1) EXPRESSION CAUSED BY ARSENITE

  N KIOKA; N HOSOKAWA; T KOMANO; K HIRAYOSHI; K NAGATA; K UEDA

  FEBS LETTERS, Apr. 1992, Peer-reviewed

  
• FLAVONOIDS INHIBIT THE EXPRESSION OF HEAT-SHOCK PROTEINS

  N HOSOKAWA; K HIRAYOSHI; A NAKAI; Y HOSOKAWA; N MARUI; M YOSHIDA; T SAKAI; H NISHINO; A AOIKE; K KAWAI; K NAGATA

  CELL STRUCTURE AND FUNCTION, Dec. 1990, Peer-reviewed

  
• N-MYC SUPPRESSION AND CELL-CYCLE ARREST AT G1 PHASE BY PROSTAGLANDINS

  N MARUI; T SAKAI; N HOSOKAWA; M YOSHIDA; A AOIKE; K KAWAI; H NISHINO; M FUKUSHIMA

  FEBS LETTERS, Sep. 1990, Peer-reviewed

  
• INHIBITORY EFFECT OF QUERCETIN ON THE SYNTHESIS OF A POSSIBLY CELL-CYCLE-RELATED 17-KDA PROTEIN, IN HUMAN COLON CANCER-CELLS

  N HOSOKAWA; Y HOSOKAWA; T SAKAI; M YOSHIDA; N MARUI; H NISHINO; K KAWAI; A AOIKE

  INTERNATIONAL JOURNAL OF CANCER, Jun. 1990, Peer-reviewed

  
• THE EFFECT OF QUERCETIN ON CELL-CYCLE PROGRESSION AND GROWTH OF HUMAN GASTRIC-CANCER CELLS

  M YOSHIDA; T SAKAI; N HOSOKAWA; N MARUI; K MATSUMOTO; A FUJIOKA; H NISHINO; A AOIKE

  FEBS LETTERS, Jan. 1990, Peer-reviewed

  

Misc.

• 小胞体品質管理とERAD--EDEM分子は糖蛋白質のERADを促進する (細胞における 蛋白質の一生--生成・成熟・輸送・管理・分解・病態) -- (蛋白質の品質管理)

  細川 暢子

  蛋白質核酸酵素, May 2004

  
• 2P193 Cell cycle-dependent dynamics of the endoplasmic reticulum (ER) in mammalian cells (II) : Mechanism of membrane fusion of the ER

  Kano F.; Kondo H.; Yamauchi S.; Tanaka A.R.; Hosokawa N.; Nagata K.; Murata M.

  Seibutsu Butsuri, 2004

  
• EMBRYOID BODIES DERIVED FROM HSP47-KNOCKOUT EMBRYONIC STEM CELLS ARE DEFICIENT IN BASEMENT MEMBRANE FORMATION DURING EMBRYONIC DEVELOPMENT

  Matsuoka Yasuhiro; Adachi Eijiro; Nagai Naoko; Hosokawa Nobuko; Kubota Hiroshi; Nagata Kazuhiro

  Connective tissue, Apr. 2002

  
• IDENTIFICATION OF CIS-ELEMENTS AND TRANSCRIPTION FACTORS THAT REGULATE THE TISSUE SPECIFIC EXPRESSION OF HSP47

  Yasuda Kunihiko; Hirayoshi Kazunori; Hosokawa Nobuko; Nagata Kazuhiro

  Connective tissue, Apr. 2002

  
• Promoter Analysis of HSP47, a Collagen Specific Molecular Chaperone

  HIRATA Hiromi; YAMAMURA Isao; HIRAYOSHI Kazunori; HOSOKAWA Nobuko; NAGATA Kazuhiro

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Cloning, expression, and characterization of EDEM homolog proteins

  Y Natsuka; K Hirao; J Nakamura; S Natsuka; N Hosokawa; K Nagata

  GLYCOBIOLOGY, Nov. 2004

  
• 小胞体シャペロンタンパク質SDF2L1の機能解析

  田中雄大; 藤森力; 宮崎恵里; 花房賢; 寿野良二; 細川暢子

  日本生化学会大会(Web), 2015

  
• 蛋白質の一生

  徳永文稔; 門脇寿枝; 西頭英起; 内木宏延; 樋口京一; 中矢正; 鈴木利治; 後藤祐児; 船津高志; 金子清俊; 中戸川仁; 森和俊; 米田悦啓; 垣塚彰; 馬艶; 久野高義; 和田郁夫; 西川周一; 伊川正人; 吉田賢右; 遠藤斗志也; 永田和宏; 阿部哲也; 養王田正文; 金城政孝; 元島史尋; 田口英樹; 吉田祐美; 中村暢宏; 阪口雅郎; 小椋光; 森正敬; 稲葉謙次; 久保田広志; 森戸大介; 細川暢子; 大塚健三; 秋山芳展; 徳田元; 藤木幸夫

  蛋白質 核酸 酵素, 10 Jun. 2008

  
• Functional analysis of EDEM homologue protein

  Yuko Natsuka; Kazuyoshi Hirao; Junji Nakamura; Taku Tamura; Ikuo Wada; Shunji Natsuka; Nobuko Hosokawa; Kazuhiro Nagata

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha 1-antitrypsin

  Nobuko Hosokawa; Ikuo Wada; Yuko Natsuka; Kazuhiro Nagata

  CELL STRUCTURE AND FUNCTION, May 2004

  
• EDEM cooperates with calnexin in the ER associated degradation of unfolded proteins

  Yukako Oda; Nobuko Hosokawa; Kazuhiro Nagata

  EURESCO Conferences on Biology of Molecular Chaperones, 2003

  
• Possible functions of EDEM in the ERAD of terminally misfolded proteins

  Kazuhiro Nagata; Yukako Oda; Kazuyoshi Hirao; Nobuko Hosokawa

  1st International Congress on Stress Responses in Biology and Medicine, 2003

  
• ERADにおけるEDEMとcalnexinの機能解析

  ODA YUKAKO; HOSOKAWA NOBUKO; WADA IKUO; NAGATA KAZUHIRO

  日本細胞生物学会大会講演要旨集, 2003

  
• ERAD 経路におけるEDEM-calnexin complex の解析

  小田裕香子; 細川暢子; 和田郁夫; 永田和宏

  第25回日本分子生物学会年会, 2002

  
• Quality control of the nascent proteins in the endoplasmic reticulum

  Kazuhiro Nagata; Yukako Oda; Nobuko Hosokawa

  The 4th APOCB Congress, The Asian Pacific Organization for Cell Biology, 2002

  
• ERAD経路においてEDEMと相互作用するタンパク質との解析

  ODA YUKAKO; HOSOKAWA NOBUKO; WADA IKUO; NAGATA KAZUHIRO

  日本細胞生物学会大会講演要旨集, 2002

  
• 新規小胞体α‐mannosidase様蛋白質(Mnl1p)は糖蛋白質の小胞体蛋白質分解(ERAD)に関与する

  中務邦雄; 西川周一; 細川暢子; 永田和宏; 遠藤斗志也

  日本細胞生物学会大会講演要旨集, 2001

  
• HSP47の組織特異的発現は2つのシスエレメントにより制御されている

  平田普三; 山村功; 安田邦彦; 小林明央; 多田昇弘; 鈴木操; 平芳一法; 細川暢子; 永田和宏

  日本細胞生物学会大会講演要旨集, 1999

  
• コラーゲン特異的分子シャペロンHSP47・ノックアウトマウスの解析

  永井尚子; 糸原重美; 細川昌則; 細川暢子; 永田和宏

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• コラーゲン特異的分子シャペロンHSP47のプロモーター解析

  平田普三; 細川暢子; 永田和宏

  日本細胞生物学会大会講演要旨集, 1997

  
• 糖タンパク質の品質管理－小胞体における糖鎖の「枝」の役割－

  細川暢子

  ポスター2 糖タンパク質の品質管理－小胞体における糖鎖の「枝」の役割－ 細川暢子（細胞機能調節学分野） 「再生医学・再生医療の先端融合的共同研究拠点」 平成24 年度学術講演会 開催日：2012 年12 月19 日（水）, 2012, Peer-reviewed

  
• Roles of N-glycans in the regulation of mammalian glycoprotein quality control.

  Hosokawa N

  第34 回日本分子生 物学会年会シンポジウム “Glycoprotein quality control: Biosynthesis, molecular recognition and physiological roles of N-glycans”（ 2011.12.16 横浜）, 16 Dec. 2011, Peer-reviewed

  
• The novel role of MRH domain-containing lectin \nXTP3-B in endoplasmic reticulum quality control

  Fujimori T; Kamiya Y; Kato K; Nagata K; Hosokawa N

  第34 回日本分子生物学会年会（2011.12.13-16 横浜）（口頭及びポスター発表）, 13 Dec. 2011, Peer-reviewed

  
• Functional analysis of MRH domain-containing lectin \nXTP3-B in the endoplasmic reticulum quality control.

  Fujimori T; Kamiya Y; Kato K; Nagata K; Hosokawa N

  The 31st Naito Conference on Glycan Expression and Regulation [II] Metabolites, Stress response, Microdomains, and Beyond.（2011.9.13-16 Sapporo）（ポスター 発表）, 2011, Peer-reviewed

  
• Functional analysis of a \nmammalian lectin XTP3-B in the endoplasmic reticulum quality control

  Tsutomu Fujimori; Yukiko Kamiya; Koichi Kato; Kazuhiro Nagata; Nobuko Hosokawa

  The 3rd International Symposium on Protein Community，奈良市，2010.9.13－16, 2010, Peer-reviewed

  
• Formation of HRD1-SEL1L ubiquitin ligase \ncomplex that regulates the mammalian ERAD

  Nobuko Hosokawa; Yasutaka Iida; Katsuya Okawa; Kazuhiro Nagata

  The 3rd International Symposium on Protein Community， 奈良市，2010.9.13－16, 2010, Peer-reviewed

  
• 小胞体関連分解におけるHRD1-SEL1L ユビキチンリガーゼ複合体の機能

  細川暢子

  京都大学再生医科学研究所 \n「再生医学・再生医療の先端融合的共同研究拠点」 \n平成22 年度学術講演会 \n開催日：2010 年12 月13 日（月） \n場所：芝蘭会館稲盛ホール, 2010, Peer-reviewed

  
• ヒト新規レクチンXTP3-B の機能解析

  藤森力; 神谷由紀子; 加藤晃一; 永田和宏; 細川暢子

  特定領域研究 「タンパク質の社会」第3 回若手ワークショップ，宗像市，2010.07.1－3, 2010, Peer-reviewed

  
• OS-9 and XTP3-B, the MRH Domain-Containing Lectins in Mammals are Involved in ERAD

  Nobuko Hosokawa

  GLYCOBIOLOGY, Nov. 2009, Peer-reviewed

  
• タンパク質の品質管理機構

  細川暢子

  京都府立医科大学大学院医学研究科・免疫・微生物学セミナー，京都市， 2009.08.28, 2009, Peer-reviewed

  
• 小胞体関連分解に関わるHRD1-SEL1L複合体の安定性と機能

  飯田恭崇; 細川暢子; 永田和宏

  第82 回日本生化学会大会，神戸市，2009.10.21－24, 2009, Peer-reviewed

  
• 小胞体レクチンによる糖タンパク質の品質管理機構

  細川暢子; 和田郁夫; 神谷由紀子; 加藤晃一; 永田和宏

  第 61 回日本細胞生物学会大会，名古屋市，2009.06.02－04, 2009, Peer-reviewed

  
• Quality control of proteins in the \nendoplasmic reticlum.

  Nobuko Hosokawa; Ikuo Wada; Yukiko Kamiya; Koichi Kato; Kazuhiro Nagata

  京都大学再生医科学研究所設立10周年記念国際シンポジウム，京都市，2008.12.4, 2008, Peer-reviewed

  
• 新規レクチンによる小胞体タンパク質品質管理 機構

  細川暢子; 和田郁夫; 長澤孝治; 森山達哉; 大川克也; 永田和宏

  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会一般口頭発表およびポスター発表，神 戸市，2008.12.9-12, 2008, Peer-reviewed

  
• Human XTP3- B forms an ER quality-control Scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP．

  Nobuko Hosokawa; Ikuo Wada; Koji Nagasawa; Tetsuya Moriyama; Katsuya Okawa; Kazuhiro Nagata

  特定領域研究 「タンパク質の一生」ポストシンポジウム，熱海市，2007.11.22－23, 2007, Peer-reviewed

  
• The clearance of misfolded CFTR mutant involves the ER membrane ubiquitin ligase, gp78.

  Daisuke Morito; Kazuyoshi Hirao; Nobuko Hosokawa; Fuminori Tokunaga; Kazuhiro Nagata

  2006 FASEB Summer Research Conferences Protein Folding in the Cell，Vermont （USA），2006.7.29－8.3, 2006, Peer-reviewed

  
• 小胞体膜貫通型ユビキチンリガーゼ gp78 のE4 活性による変異型CFTR のユビキチン化

  森戸大介; 平尾和義; 細川暢子; 徳永文稔; 田中啓二; 岩井一宏; 永田和宏

  第1 回臨床ストレス応答学会大会，京都市，2006.11.22 －23, 2006, Peer-reviewed

  
• 小胞体関連分解におけるユビキチンリガーゼの機能分担

  森戸大介; 平尾和義; 細川暢子; 永田和宏

  2005年度科 学技術振興機構戦略的創造研究推進事業“たんぱく質関連領域”合同シンポジウム, 豊中市, 2005. 11. 15－16, 15 Nov. 2005, Peer-reviewed

  
• EDEM3 たんぱく質は糖たんぱく質の分解を促進する

  細川暢子; 平尾和義; 中村純治; 森戸大介; 長束優子; 和田郁夫; Pedro Romero; Barry Sleno; Linda O. Tremblay; Annette Herscovics; 永田和宏

  2005 年度科学技術振 興機構戦略的創造研究推進事業“たんぱく質関連領域”合同シンポジウム, 豊中市, 2005. 11. 15－16, 15 Nov. 2005, Peer-reviewed

  
• Involvement of TRAP complex in ERAD pathway.

  Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Kazuhiro Nagata

  International Symposium on Life of Proteins, Awaji （Japan）, 2005. 10. 30－11. 3, 30 Oct. 2005, Peer-reviewed

  
• 小胞体膜蛋白質Herp はPNGase と結合し, 小胞関連分解基質の脱糖鎖を促進する

  菊池唯史; 細川暢子; 永田和宏; 鈴木匡; 宮田敏行; 小亀浩市

  第78 回日本生化学会ワークショップ「小胞体の蛋白質品質管理」, 神戸市, 2005. 10. 19, 19 Oct. 2005, Peer-reviewed

  
• TRAP complex is involved in ERAD pathway

  Koji Nagasawa; Toshio Higashi; Nobuko Hosokawa; Kazuhiro Nagata

  CELL STRUCTURE AND FUNCTION, Jun. 2005, Peer-reviewed

  
• Dissection of functional differences between two mammalian Hrd1p orthologues: gp78 and mHRD1

  Daisuke Morito; Kazuyoshi Hirao; Nobuko Hosokawa; Kazuhiro Nagata

  CELL STRUCTURE AND FUNCTION, Jun. 2005, Peer-reviewed

  
• EDEM 可溶性ホモログ EDEM3はマンノシダーゼ活性を介してERADを促進する

  長束優子; 平尾和義; 中村純治; 田村拓; 和田郁夫; 長束俊治; 細川暢子; 永田和宏

  第25回日本糖質学会年会, 大津市, 2005. 7. 20－22, 2005, Peer-reviewed

  
• Alpha-mannosidase-like proteins accelerate glycoprotein ERAD \n基盤研究C 企画調査「タンパ ク質の多様性獲得戦略の解明に基づいたゲノム情報の解読」

  Nobuko Hosokawa

  シンポジウム「Strategies for the acquirement of functional diversity of proteins タンパク質の多様性は限られたゲノム情報からいかにして生み出されるか？」, 東京都, 2005. 1. 20, 2005, Peer-reviewed

  
• ER-associate degradation : EDEM, soluble EDEM and more...

  Kazuhiro Nagata; Nobuko Hosokawa

  The 1st Pacific- Rim International Conference on Protein Science（2004.4.16. Yokohama）, 2004, Peer-reviewed

  
• A soluble homologue of EDEM accelerate ER-associated degradation

  Kazuyoshi Hirao; Daisuke Morito; Yoko Natsuka; Nobuko Hosokawa; Yoshihide Hayashizaki; Kazuhiro Nagata

  CELL STRUCTURE AND FUNCTION, May 2004, Peer-reviewed

  
• Simultaneous induction of all subunits of TRAP gene by ER stress

  Koji Nagasawa; Toshio Hijzashi; Nobuko Hosokawa; Kazuhiro Nagata

  CELL STRUCTURE AND FUNCTION, May 2004, Peer-reviewed

  
• Differential expression of EDEM and solEDEM (EDEM soluble homologue) mRNAs during embryonic development of the mice

  Junji Nakamura; Kazuhiro Nagata; Nobuko Hosokawa

  CELL STRUCTURE AND FUNCTION, May 2004, Peer-reviewed

  
• 糖タンパク質の小胞体関連分解：小胞体マンノ シダーゼI, EDEM, EDEM ホモログタンパク質は，いずれも糖タンパク質のERAD を促進する

  細川暢子; 平尾和義; 中村純治; 長束優子; 和田郁夫; 永田和宏

  第77 回日本生化学会大会シンポジウム「糖タンパク質のフォールディングとプロセシングの品質管理」（2004.10.15. 横浜市）, 2004, Peer-reviewed

  
• 小胞体の品質管理機構－細胞内メカニズム－

  細川暢子

  千里ライフサイエンスセミナー「タンパク質のクオリティ コントロールとその破綻」（2004.9.7. 豊中市）, 2004, Peer-reviewed

  
• 小胞体膜蛋白質Herp は小胞体関連分解基質の脱糖鎖と分解に関与する

  菊池唯史; 細川暢子; 永田和宏; 宮田敏行; 小亀浩市

  第27 回日本分子生物学会大会（2004.12.10. 神戸市）, 2004, Peer-reviewed

  
• 細胞周期依存的なER exit site のダイナミクス（Ⅱ）：ER－ゴルジ体小胞輸送への影響

  山内忍; 加納ふみ; 近藤久雄; 田中亜路; 土田マーク彰; 細川暢子; 永田和宏; 村田昌之

  第27 回日本分子生物学会大会（2004.12.9. 神戸市）, 2004, Peer-reviewed

  
• 哺乳類HRD1 ホモログの基質選択の解析

  森戸大介; 平尾和義; 細川暢子; 永田和宏

  第27 回日本分子生物学会大会（2004.12.9. 神戸市）, 2004, Peer-reviewed

  
• EDEM ホモログ蛋白質 の機能解析

  長束優子; 平尾和義; 中村純治; 田村拓; 和田郁夫; 長束俊治; 細川暢子; 永田和宏

  第77 回日本生化学会大会（2004.10.15. 横浜市）, 2004, Peer-reviewed

  
• 糖タンパク質の小胞体関連分解に関わる マンノシダーゼ様タンパク質

  細川暢子; 平尾和義; 中村純治; 長束優子; 和田郁夫; 永田和宏

  文部科学省特定領域研究「糖鎖によるタンパク質と分子複合体の機能調節」夏期シンポジウム（2004.8.26～27. 木更津市）, 2004, Peer-reviewed

  

Presentations

• ERp46 triggers mannose trimming activity of EDEM3.

  HOSOKAWA Nobuko

  International Symposium on ER stress, glycosylation, homeostasis and diseases, 22 Mar. 2018, Invited

  
• 小胞体関連分解を担うHRD1-SEL1Lユビキチンリガーゼ複合体の機能解析

  細川 暢子

  第34回日本糖質学会年会, 01 Aug. 2015, Invited

  
• 小胞体膜におけるプロテオスタシス維持機構

  第36回日本分子生物学会年会ワークショップ「ER・Post-ERにおける膜プロテオスタシスネットワーク研究の新展開」, 05 Dec. 2013, 日本分子生物学会

  
• Homeostasis and quality control of proteins in cells

  The Joint Symposium of the 7th International Symposium of the Institute Network and the 45th IDAC Symposium, the 2nd Symposium for Joint Usage/Research Center of Aging. “Research Frontiers for Smart Aging” （仙台市）, 15 Jun. 2012, The 7th International Symposium of the Institute Network

  
• Roles of N-glycans in the regulation of mammalian glycoprotein quality control

  第34回日本分子生物学会年会回日本分子生物学会年会シンポジウム｢Glycoprotein quality control: Biosynthesis, moelecular recognition and physiological roles of N-glycans｣, 16 Dec. 2011, 日本分子生物学会

  
• 小胞体における糖鎖修飾とタンパク質品質管理機構

  第84回日本生化学会大会シンポジウム「糖鎖修飾：システムズバイオロジーへの展望」, 22 Sep. 2011, 日本生化学会

  
• Lectins and enzymes that regulate the mammalian glycoprotein quality control

  Glycan Expression and Regulation [II] Metabolites, Stress response, Microdomains, and Beyond, 14 Sep. 2011, The 31st Naito Conference

  
• OS-9 and XTP3-B, the MRH Domain-containing Lectins in Mammals are Involved in ERAD

  Annual Conference of the Society for Glycobiology, 15 Nov. 2009, The Society for Glycobiology

  
• 新規小胞体レクチンによる糖タンパク質の品質管理機構

  第6回 糖鎖科学コンソーシアムシンポジウム, 03 Dec. 2008, 糖鎖科学コンソーシアム

  
• 小胞体関連分解を促進するEDEMファミリータンパク質の機能解析

  文部科学省特定領域研究「糖鎖によるタンパク質と分子複合体の機能調節」第4回公開シンポジウム, 31 Jan. 2006, 文部科学省特定領域研究「糖鎖によるタンパク質と分子複合体の機能調節」

  
• 小胞体の品質管理機構

  第７回GGA-HSP勉強会, 27 Aug. 2005

  
• α-Mannosidase-like proteins accelerate glycoprotein ERAD

  基盤研究Ｃ企画調査「タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読」シンポジウム「Strategies for the acquirement of functional diversity of proteins タンパク質の多様性は限られたゲノム情報からいかにして生み出されるか？」, 20 Jan. 2005, 基盤研究Ｃ企画調査「タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読」

  
• α-Mannosidase-like proteins involved in glycoprotein ERAD

  第27回日本分子生物学会年会ワークショップ｢タンパク質の品質管理とその破綻｣, 04 Dec. 2004, 日本分子生物学会

  
• 糖タンパク質の小胞体関連分解：小胞体マンノシダーゼI、EDEM、EDEMホモログタンパク質は、いずれも糖タンパク質のERADを促進する

  第77回日本生化学会大会シンポジウム「糖タンパク質のフォールディングとプロセシングの品質管理」, 15 Oct. 2004, 日本生化学会

  
• 小胞体の品質管理機構−細胞内メカニズム−

  千里ライフサイエンスセミナー「タンパク質のクオリティコントロールとその破綻」, 07 Sep. 2004, 千里ライフサイエンスセミナー

  
• ER Degradation of Glycoproteins

  第26回日本分子生物学会年会シンポジウム「糖鎖細胞生物学の新展開−”あいまいさ”を越えて−, 11 Dec. 2003, 日本分子生物学会

  
• 糖タンパク質の小胞体関連分解

  平成15年度生化学会近畿支部シンポジウム「細胞内品質管理のダイナミズム」, 21 Nov. 2003, 生化学会近畿支部

  
• 小胞体品質管理に関わるEDEM 蛋白質の機能解析

  第56回日本細胞生物学会大会ワークショップ「タンパク質：生と死の生物学」, 16 May 2003, 日本細胞生物学会

  
• 小胞体関連分解におけるEDEM 蛋白質の機能

  第25 回日本分子生物学会年会ワークショップ, 11 Dec. 2002, 日本分子生物学会

  
• 糖蛋白質の小胞体関連分解

  第7回病態と治療におけるプロテアーゼとインヒビター研究会, 16 Aug. 2002, 病態と治療におけるプロテアーゼとインヒビター研究会

  
• 小胞体関連分解(ERAD)に関与する、EDEM 蛋白質の機能解析

  第55回日本細胞生物学会大会ワークショップ, 21 May 2002, 日本細胞生物学会

  
• 細胞環境を創るストレスタンパク質：コラーゲン特異的分子シャペロンHSP47 による細胞機能制御

  文部省基盤C シンポジウム「脳の形成」と「生活習慣病予防」に運動が必要なわけを探る, 01 Mar. 2002, 文部省基盤C シンポジウム

  
• 小胞体ストレスと小胞体関連分解

  千里ライフサイエンスセミナー, 14 Dec. 2001, 千里ライフサイエンスセミナー

  
• 小胞体関連分解“シグナル”認識機構

  第７４回日本生化学会大会シンポジウム, 28 Oct. 2001, 日本生化学会

  
• A novel ER α-mannosidase-like protein accelerates ER-associated degradation.

  8th CGGH Symposium "New Paradigms of Molecular Chaperones in the Postgenome Era", 07 Aug. 2001

  
• 小胞体関連分解(ERAD) を促進するα-mannosidase 様蛋白質の機能解析

  第73回日本生化学会大会シンポジウム, 11 Oct. 2000, 日本生化学会

  
• フラボノイドによる熱ショック蛋白質誘導の阻害

  Japanese Society for Food Factors シンポジウム, 10 Dec. 1996, Japanese Society for Food Factors

  

Books and Other Publications

• ERAD（小胞体関連分解）を制御するレクチンOS-9とXTP3-B.

  細川暢子

  日本生化学会, 2011, Not refereed

  
• N.: Isolation and binding assay of EDEMs

  Hosokawa N, Single work

  GlycoPOD web site（Ed. T. Kawasaki）: <9>-9（2011）, 2011, Not refereed

  
• Mannose 6-phosphate receptor homology domain-containing lectins in mammalian endoplasmic reticulum-associated degradation.

  Hosokawa N; Kato K; Kamiya Y

  Methods in Enzymology: 480 (Ed. M. Fukuda) Elsevier, 181-197, 2010, Not refereed

  
• M-type lectins as novel components of secretory pathways.

  Hosokawa N; Nagata K

  “Animal Lectins: A Functional View” (Eds. G. R. Vasta, H. Ahmed) CRC Press, 165-169, 2009, Not refereed

  
• キーワード：タンパク質の一生 (編集：遠藤斗志也、小椋光、永田和宏、田口英樹、吉田賢右)

  細川暢子

  蛋白質核酸酵素 Vol. 53, No.8、分担, 2008, Not refereed

  
• Degradation of misfolded glycoproteins in the endoplasmic reticulum.

  Hosokawa N

  “Experimental Glycoscience Glycobiology” (Eds. N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki, S. Hase) Springer, 207-210, 2008, Not refereed

  
• 小胞体関連分解におけるEDEMファミリータンパク質の機能．

  長束優子; 細川暢子; 永田和宏

  実験医学「細胞内タンパク質の社会学」（永田和宏、遠藤斗志也編）Vol.23, No.15: 2352-2357, 2005, Not refereed

  
• 小胞体におけるミスフォールドタンパク質の分解機構

  細川暢子

  未来を拓く糖鎖科学 (監修 永井克孝):263-264, 2005, Not refereed

  
• 小胞体タンパク質の品質を保証する細胞内メカニズム．

  細川暢子

  日本農芸化学会, 2005, Not refereed

  
• 小胞体関連分解(ERAD)

  細川暢子

  生体の科学Vol.55, No.5: 416-417, 2004, Not refereed

  
• 小胞体タンパク質品質管理とERAD-EDEM分子は糖タンパク質のERADを促進する.

  細川暢子

  蛋白質核酸酵素「細胞における蛋白質の一生」Vol.49, No.7: 984-987, 2004, Not refereed

  
• 小胞体でつくられたタンパク質の運命

  細川暢子; 永田和宏

  実験医学Vol.21, No.7: 細胞内タンパク質の運命」, 892-897, 2003, Not refereed

  
• ERADによる品質管理機構

  細川暢子; 永田和宏

  日本生化学会, 2003, Not refereed

  
• 小胞体関連分解(ERAD)（小胞体蛋白質分解系）

  細川暢子

  初耳辞典, 2003, Not refereed

  
• 小胞体ストレスと小胞体関連分解

  細川暢子; 永田和宏

  「特集1 小胞体ストレスと神経細胞死」脳21 金宝堂 Vol.5, No. 2: 126-129, 2002, Not refereed

  
• Involvement of HSP47 in the Folding and Processing of Procollagen in the Endoplasmic Reticulum.

  Nagata K; Satoh M; Hosokawa N; Miller A.D

  Molecular Chaperones in the Life Cycle of Proteins,, 1997, Not refereed

  

External funds: Kakenhi

• Study on the intracellular transsport mechanism of collagens

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44010:Cell biology-related

  Kyoto University

  Nobuko Hosokawa

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  コラーゲン;細胞内輸送;小胞体;ゴルジ装置;蛍光タンパク質;小胞輸送;ライブセルイメージング;ライブイメージング;哺乳類細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06214/
• Study on the protein quality control mechanism in the endoplasmic reticulum

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Nobuko Hosokawa

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  小胞体;タンパク質品質管理;シャペロンタンパク質;タンパク質分解;小胞体関連分解;動物細胞;糖タンパク質;マンノシダーゼ;ユビキチンリガーゼ複合体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26440096/
• Analysis of the ubiquitin-ligase complex in the endoplasmic reticulum membrane that regulates endoplasmic reticulum-associated degradation in mammals

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Nobuko HOSOKAWA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  小胞体;小胞体関連分解;ユビキチンリガーゼ;タンパク質品質管理;HRD1-SEL1L複合体;レクチン;タンパク質;ユビキチンプロテアソーム系;糖鎖;タンパク質分解;分子細胞生物学;HRD1-SEL1L

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22570183/
• レクチンとシャペロンを介した小胞体タンパク質の品質管理

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  細川 暢子

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  タンパク質品質管理;分子シャペロンタンパク質;レクチン;小胞体;小胞体関連分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22020020/
• Quality control mechanism of misfolded proteins

  Grant-in-Aid for Creative Scientific Research

  Kyoto Sangyo University;Kyoto University

  Kazuhiro NAGATA

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  品質管理;フォールディング;レドックス;小胞体;小胞体品質管理;ジスルフィド結合;EDEM;ERdj5;分子シャペロン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19GS0314/
• ユビキチンリガーゼ複合体による小胞体関連タンパク質分解機構の研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  細川 暢子

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  小胞体タンパク質分解;ユビキチンリガーゼ;小胞体品質管理;糖タンパク質;小胞体;小胞体シャペロンタンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19044022/
• Analysis of the molecular mechanism ofendoplasmic reticulum-associated protein degradation (ERAD)

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Nobuko HOSOKAWA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  小胞体;小胞体関連分解;品質管理;細胞内輸送;糖タンパク;分子シャペロン;糖タンパク質, endoplasmic reticulum (ER);ER-associated protein degradation (ERAD);ER quality control (ERQC);intracellular transport;glycoprotein;molecular chaperone

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17570161/
• 糖タンパク質の小胞体品質管理機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  細川 暢子

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  N結合型糖鎖;糖タンパク質;小胞体品質管理;α-マンノシダーゼ;小胞体関連分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17046009/
• Quality control mechanism for positive and negative

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Kazuhiro NAGATA

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  分子シャペロン;品質管理;小胞体関連分解;EDEM, Molecular Chaperone;Quality control;ER associated degradation;EDEM

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16207013/
• Functional analysis of EDEM which accelerates glycoprotein ERAD

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Nobuko HOSOKAWA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  小胞体関連分解;小胞体品質管理;小胞体;糖タンパク質;小胞体シャペロンタンパク質;小胞体ストレス;α-マンノシダーゼ;小胞体マンノシターゼI, ERAD(ER associated degradation);ER quality control;ER(endoplasmic reticulum);glycoproteins;ER chaperone proteins;ER stress;α-mannosidase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15570157/
• 糖鎖による蛋白質の小胞体品質管理機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  細川 暢子

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  N結合型糖鎖;糖タンパク質;小胞体品質管理;α-マンノシダーゼ;小胞体関連分野;N型糖鎖;小胞体マンノシダーゼI;小胞体関連分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15040213/
• Molecular mechanism of ER-related degradation

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Kazuhiro NAGATA

  From 01 Apr. 2002, To 31 Mar. 2007, Project Closed

  分子シャペロン;品質管理;小胞体関連分解;EDEM;小胞体関連分野;分子シヤペロン, Molecular Chaperone;Quality control;ER associated degradation;EDEM

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14037230/
• Funcioal analysis of mouse EDEM, which eaocelerales gyocprotein ERAD

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Nobuko HOSOKAWA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  小胞体関連分解;品質管理機構;糖タンパク質;小胞体マンノシダーゼ;小胞体;糖蛋白質;小胞体マンノンダーゼ, ERAD(ER associated degadation);ER quality control;Glyooprotein;ER marnosidase I;ER(endoplasmicreticulun)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680780/
• コラーゲン特異的分予シャペロンHSP47の構造と機能

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  永田 和宏

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  HSP47;コラーゲン;semi-permeabilized cell;ノックアウトマウス;分子シャペロン;結晶解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11694271/
• A Search for a new chaperone proteins on the endoplasmic retical

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Nobuko HOSOKAWA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  小胞体;小胞体関連分解;α-マンノシダーゼ;小胞体の品質管理機構;糖蛋白質;小胞体関係連分解;分子シャペロン;品質管理機構;小胞体関連蛋白質分解, Endoplasmic Reticulum;ERADC Endoplasmic reticulum associated degradation;d-Mannosidase;Quality Control of the Endoplasmic Reticulum;Glycoprotein

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680695/
• コラーゲン特異的分子シャペロンによる癌細胞の浸潤転移制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  永田 和宏

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  ストレス蛋白質;HSP47;プロコラーゲン;分子シャペロン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08265230/
• The role of collagen-specific molecular chaperone HSP47

  Grant-in-Aid for international Scientific Research

  KYOTO UNIVERSITY

  Kazuhiro NAGATA

  From 01 Apr. 1994, To 31 Mar. 1997, Project Closed

  ストレス蛋白質;HSP47;プロコラーゲン;分子シャペロン;コラーゲン;細胞内輸送, stress protein;HSP47;procollagen;molecular chaperone

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06044125/

External funds: others

• 糖タンパク質の小胞体品質管理機構の解明

  上原記念生命科学財団研究助成金

  From 2007, To 2007

  細川暢子
• 小胞体関連分解を担うEDEMファミリータンパク質の機能解析

  公益信託林女性自然科学者研究助成基金

  From 2009, To 2010

  細川暢子
• Functional analysis of N-glycans on the quality control of proteins

  水谷糖質科学振興財団

  From 2012, To 2012

  細川暢子
• 小胞体ストレスによって神経細胞特異的に発現誘導を受ける遺伝子群の解析

  第34回内藤記念科学奨励金（研究助成）

  From 2012, To 2012

  細川暢子

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IIC

  9125, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IB

  9120, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IID

  9126, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology ID

  9122, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IIB

  9124, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IA

  9119, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IC

  9121, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Molecular and Cellular Biology IIA

  9123, Spring, Graduate School of Science, 1
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅠＡ

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅠB

  Fall, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅠC

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅠD

  Fall, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅡＡ

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅡB

  Fall, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅡC

  Spring, 理学研究科
• From Apr. 2011, To Mar. 2012

  分子細胞生物学ゼミナールⅡD

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Developmental Biology and Regenerative Medicine

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Developmental Biology and Regenerative Medicine

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Course on Biological Science A

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IA

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IB

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IC

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology ID

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IIA

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IIB

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IIC

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Molecular and Cellular Biology IID

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Course on Biological Science A

  Spring, 理学研究科

Participation in PhD Defense

• SEL1Lの分解中間体はポリグルタミンタンパク質の細胞質での凝集を促進する

  HATTORI TOKUYA, Graduate School of Science, Chief Examiner

  24 Jan. 2022

Administration

School management (title, position)

• From 01 Apr. 2009, To 31 Mar. 2010

  組換えDNA実験安全委員会 委員
• From 01 Feb. 2018, To 31 Mar. 2020

  衛生管理者

Faculty management (title, position)

• From 01 Apr. 2021

  安全衛生委員会　委員
• From 01 Jul. 2021

  再生実験動物施設飼育室施設運営委員会 委員
• From 01 Apr. 2016, To 31 Mar. 2018

  将来計画・評価員会委員
• From 01 Apr. 2016, To 31 Mar. 2018

  予算委員会委員
• From 01 Oct. 2016, To 30 Jun. 2021

  再生医科学動物実験専門委員会　委員
• From 01 Oct. 2016

  （旧再生研）予算委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2020

  安全衛生委員会
• 人権委員会　委員
• 動物実験委員会　委員
• 放射線障害防止委員会