Basic Information

Faculty

• 薬学部

Professional Memberships

• From 2015, To Present

  日本NO学会
• From 2010, To Present

  日本基礎老化学会
• From 2008, To Present

  日本解剖学会
• From 2001, To Present

  日本薬理学会
• From 1998, To Present

  日本生理学会
• From 1997, To Present

  北米神経科学会
• From 1997, To Present

  Society for Neuroscience
• From 1996, To Present

  日本神経科学会
• From 1991, To Present

  日本比較内分泌学会

Academic Degree

• 修士（理学）(東京大学)
• 博士（理学）(東京大学)

Research History

• From Apr. 2010, To Present

  京都大学 薬学研究科生体分子認識学分野, 准教授
• From Apr. 2008, To Mar. 2010

  長崎大学 医歯薬学総合研究科, 講師
• From Apr. 2007, To Mar. 2008

  東京大学 医学系研究科, 助教
• From Sep. 2000, To Mar. 2007

  東京大学 医学系研究科, 助手
• From Apr. 2000, To Aug. 2000

  科学技術振興事業団戦略的基礎研究推進事業, 研究員 (脳を知る)
• From Apr. 1998, To Mar. 2000

  科学技術振興事業団戦略的基礎研究推進事業, 研究員 (生体防御のメカニズム)
• From Oct. 1997, To Mar. 1998

  RIKEN, 研究員
• From Apr. 1996, To Sep. 1997

  理化学研究所 国際フロンティア研究システム シグナル伝達機構研究チーム, 研究員
• From Apr. 1995, To Mar. 1996

  日本学術振興会, 特別研究員 (DC2)

ID,URL

• ORCID ID

  0000-0001-8396-5411

• J-Global ID

  200901055443916560

researchmap URL

• https://researchmap.jp/shokakizawa

Research

Research Topics, Overview of the research

• Research Topics

  
  I am interested in activity-dependent modification of neuronal circuits, in relation to brain functions such as learning and memory.
  My current research is plasticity and aging of central synapses and their signaling mechanisms, especially focusing on redox signals and calcium signals.

• Overview of the research

  ・Activity-dependent regulation of neuronal circuit and its molecular mechanism
  ・Age-dependent decline in brain function (brain aging) and its molecular mechanism
  ・Non-enzymatic post-translational modification of proteins and their functional roles
  ・Functional roles of redox signaling molecules in nervous systems

Research Interests

• learning and memory
• 可塑性
• シナプス
• 小脳
• プルキンエ細胞
• parallel fiber
• long-term depression
• long-term potentiation
• カルシウム
• ryanodine receptor
• redox signaling
• 一酸化窒素
• reactive oxygen specie
• antioxidant
• aging
• イメージング
• 電気生理学
• パッチクランプ法
• 登上線維
• synaptic elimination
• glutamate receptor
• 生後発達
• 発達期可塑性
• 活動依存性
• 慢性投与
• Elvax
• テトロドトキシン
• 成長因子
• IGF-I
• インタ-ロイキン6
• カルシニューリン
• FK-506
• カンナビノイド
• 遺伝子導入
• ウィルス
• 脳・神経
• 発達
• シグナル伝達
• 脳科学
• 生理学
• 薬理学
• 統合脳・分子脳科学
• 包括脳ネットワーク
• pituitary
• hormone
• somatolactin

Research Areas

• Life sciences, Physiology
• Life sciences, Nervous system function
• Life sciences, Nutrition and health science
• Life sciences, Physical and health education
• Life sciences, Neuroscience - general
• Life sciences, Pharmacology

Papers

• C型ナトリウム利尿ペプチドは軟骨細胞内Ca2+シグナル経路を活性化し骨伸長を促進する

  岡本 直樹; 市村 敦彦; 宮崎 侑; 北山 諒; 安江 智己; 劉 楓; 川邊 隆彰; 長友 宏樹; 柿澤 昌; 西 美幸; 竹島 浩

  日本薬学会年会要旨集, Mar. 2022

  
• てんかんモデルマウスにおける1型リアノジン受容体のS-ニトロシル化を介した神経細胞死(S-nitrosylation of the type 1 ryanodine receptor is critical for epileptic seizure-induced neuronal cell death)

  Mikami Yoshinori; Kanemaru Kazunori; Okubo Yohei; Nakaune Takuya; Suzuki Junji; Kakizawa Sho; Shibata Kazuki; Koyama Ryuta; Murayama Takashi; Ito Akihiro; Yamazawa Toshiko; Ito Masanori; Tomida Taichiro; Murakami Shingo; Adachi-Akahane Satomi; Ikegaya Yuji; Sakurai Takashi; Saito Nobuhito; Iino Masamitsu

  The Journal of Physiological Sciences, Mar. 2017

  
• 一酸化窒素誘導Ca2+放出 1型リアノジン受容体のS-ニトロシル化による神経細胞死(Nitric oxide-induced calcium release: S -nitrosylation of the type 1 ryanodine receptor and neuronal cell death)

  Mikami Yoshinori; Kanemaru Kazunori; Oda Yasuhiro; Kakizawa Sho; Shibata Kazuki; Sugiyama Hiroki; Koyama Ryuta; Ito Akihiro; Murayama Takashi; Yamazawa Toshiko; Watanabe Masahiko; Ikageya Yuji; Saito Nobuhito; Sakurai Takashi; Iino Masamitsu

  The Journal of Physiological Sciences, Mar. 2016

  
• A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

  Toshiko Yamazawa; Takuya Kobayashi; Nagomi Kurebayashi; Masato Konishi; Satoru Noguchi; Takayoshi Inoue; Yukiko U. Inoue; Ichizo Nishino; Shuichi Mori; Hiroto Iinuma; Noriaki Manaka; Hiroyuki Kagechika; Arkady Uryash; Jose Adams; Jose R. Lopez; Xiaochen Liu; Christine Diggle; Paul D. Allen; Sho Kakizawa; Keigo Ikeda; Bangzhong Lin; Yui Ikemi; Kazuto Nunomura; Shinsaku Nakagawa; Takashi Sakurai; Takashi Murayama

  Nature Communications, Dec. 2021, Peer-reviewed

  
• Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination.

  Ryosuke Tsumagari; Kenta Maruo; Sho Kakizawa; Shuji Ueda; Minoru Yamanoue; Hiromitsu Saito; Noboru Suzuki; Yasuhito Shirai

  International journal of molecular sciences, 23 Oct. 2020, Peer-reviewed

  
• Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.

  Sho Kakizawa; Yasushi Kishimoto; Shinichiro Yamamoto; Kazuko Onga; Kunihiko Yasuda; Yoshiaki Miyamoto; Masahiko Watanabe; Ryuichi Sakai; Nozomu Mori

  Scientific reports, 02 Sep. 2020, Peer-reviewed, Lead author, Corresponding author

  
• DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ

  Ryosuke Tsumagari; Sho Kakizawa; Sakiko Kikunaga; Yoshitaka Fujihara; Shuji Ueda; Minoru Yamanoue; Naoaki Saito; Masahito Ikawa; Yasuhito Shirai

  eneuro, Mar. 2020, Peer-reviewed

  
• TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.

  Nianchao Qian; Atsuhiko Ichimura; Daisuke Takei; Reiko Sakaguchi; Akihiro Kitani; Ryohei Nagaoka; Masato Tomizawa; Yuu Miyazaki; Hitoshi Miyachi; Tomohiro Numata; Sho Kakizawa; Miyuki Nishi; Yasuo Mori; Hiroshi Takeshima

  Science signaling, 09 Apr. 2019, Peer-reviewed

  
• Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival.

  Yoshinori Mikami; Sho Kakizawa; Toshiko Yamazawa

  International journal of molecular sciences, 29 Sep. 2016, Peer-reviewed

  
• Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.

  Yoshinori Mikami; Kazunori Kanemaru; Yohei Okubo; Takuya Nakaune; Junji Suzuki; Kazuki Shibata; Hiroki Sugiyama; Ryuta Koyama; Takashi Murayama; Akihiro Ito; Toshiko Yamazawa; Yuji Ikegaya; Takashi Sakurai; Nobuhito Saito; Sho Kakizawa; Masamitsu Iino

  EBioMedicine, Sep. 2016, Peer-reviewed, Corresponding author

  
• Involvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity.

  Shiro Baba; Kazuko Onga; Sho Kakizawa; Kyoji Ohyama; Kunihiko Yasuda; Hiroshi Otsubo; Brian W Scott; W McIntyre Burnham; Takayuki Matsuo; Izumi Nagata; Nozomu Mori

  Scientific reports, 08 Jun. 2016, Peer-reviewed

  
• Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.

  Chengzhu Zhao; Atsuhiko Ichimura; Nianchao Qian; Tsunaki Iida; Daiju Yamazaki; Naruto Noma; Masataka Asagiri; Koji Yamamoto; Shinji Komazaki; Chikara Sato; Fumiyo Aoyama; Akira Sawaguchi; Sho Kakizawa; Miyuki Nishi; Hiroshi Takeshima

  Science signaling, 17 May 2016, Peer-reviewed

  
• Nitric oxide

  Sho Kakizawa

  Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students, 01 Jan. 2016, Peer-reviewed

  
• Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.

  Bo Van; Miyuki Nishi; Shinji Komazaki; Atsuhiko Ichimura; Sho Kakizawa; Keita Nakanaga; Junken Aoki; Ki-Ho Park; Jianjie Ma; Tomomi Ueyama; Takehiro Ogata; Naoki Maruyama; Hiroshi Takeshima

  FEBS letters, 28 Apr. 2015, Peer-reviewed

  
• Critical roles of oxidative signals in age-related decline of cerebellar synaptic plasticity

  Sho Kakizawa; Nozomu Mori

  Aging Mechanisms: Longevity, Metabolism, and Brain Aging, 01 Jan. 2015, Peer-reviewed

  
• Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.

  Shinichiro Yamamoto; Tetsuo Yamazaki; Shinji Komazaki; Takeshi Yamashita; Masako Osaki; Masaya Matsubayashi; Hiroyasu Kidoya; Nobuyuki Takakura; Daiju Yamazaki; Sho Kakizawa

  Developmental biology, 01 Sep. 2014, Peer-reviewed

  
• Posttranslational modification of intercellular messenger systems.

  Sho Kakizawa; Hiroyuki Kaiya; Akiyoshi Takahashi

  Frontiers in endocrinology, 2014, Peer-reviewed

  
• Nitric Oxide-Induced Calcium Release: Activation of Type 1 Ryanodine Receptor, a Calcium Release Channel, through Non-Enzymatic Post-Translational Modification by Nitric Oxide.

  Sho Kakizawa

  Frontiers in endocrinology, 11 Oct. 2013, Peer-reviewed, Lead author, Corresponding author

  
• Facilitated hyperpolarization signaling in vascular smooth muscle-overexpressing TRIC-A channels.

  Shengchen Tao; Daiju Yamazaki; Shinji Komazaki; Chengzhu Zhao; Tsunaki Iida; Sho Kakizawa; Yuji Imaizumi; Hiroshi Takeshima

  The Journal of biological chemistry, 31 May 2013, Peer-reviewed

  
• Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor by endogenous nitric oxide.

  Sho Kakizawa; Toshiko Yamazawa; Masamitsu Iino

  Channels (Austin, Tex.), 01 Jan. 2013, Peer-reviewed, Lead author, Corresponding author

  
• TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.

  Miyuki Nishi; Fumiyo Aoyama; Fumihiko Kisa; Hua Zhu; Mingzhai Sun; Peihui Lin; Hiroya Ohta; Bo Van; Shinichiro Yamamoto; Sho Kakizawa; Hideki Sakai; Jianjie Ma; Akira Sawaguchi; Hiroshi Takeshima

  The Journal of biological chemistry, 28 Sep. 2012, Peer-reviewed

  
• Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity.

  Sho Kakizawa; Masahiko Shibazaki; Nozomu Mori

  Neurobiology of aging, Mar. 2012, Peer-reviewed, Lead author, Corresponding author

  
• Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.

  Sho Kakizawa; Toshiko Yamazawa; Yili Chen; Akihiro Ito; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Osamu Sato; Masahiko Watanabe; Nozomu Mori; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Nobuhito Saito; Masamitsu Iino

  The EMBO journal, 18 Jan. 2012, Peer-reviewed, Lead author, Corresponding author

  
• A Novel Calcium-Mobilizing Mechanism Mediated by S-nitrosylation-Dependent Modulation of Ryanodine Receptor

  Kakizawa S; Takeshima H; Iino M

  Meesenger, 2012, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Molecular architecture of Ca2+ signaling control in muscle and heart cells

  Xiaoli Zhao; Daiju Yamazaki; Sho Kakizawa; Zui Pan; Hiroshi Takeshima; Jianjie Ma

  CHANNELS, Sep. 2011, Peer-reviewed

  
• TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance.

  Daiju Yamazaki; Yasuharu Tabara; Satomi Kita; Hironori Hanada; Shinji Komazaki; Daisuke Naitou; Aya Mishima; Miyuki Nishi; Hisao Yamamura; Shinichiro Yamamoto; Sho Kakizawa; Hitoshi Miyachi; Shintaro Yamamoto; Toshiyuki Miyata; Yuhei Kawano; Kei Kamide; Toshio Ogihara; Akira Hata; Satoshi Umemura; Masayoshi Soma; Norio Takahashi; Yuji Imaizumi; Tetsuro Miki; Takahiro Iwamoto; Hiroshi Takeshima

  Cell metabolism, 03 Aug. 2011, Peer-reviewed

  
• Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel.

  Elisa Venturi; Kazuhiro Mio; Miyuki Nishi; Toshihiko Ogura; Toshio Moriya; Samantha J Pitt; Kazutaka Okuda; Sho Kakizawa; Rebecca Sitsapesan; Chikara Sato; Hiroshi Takeshima

  Biochemistry, 05 Apr. 2011, Peer-reviewed

  
• Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.

  Sho Kakizawa; Shigeki Moriguchi; Atsushi Ikeda; Masamitsu Iino; Hiroshi Takeshima

  Cerebellum (London, England), 2008, Peer-reviewed, Lead author

  
• Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells.

  Yuji Kamikubo; Toshihide Tabata; Sho Kakizawa; Daisuke Kawakami; Masahiko Watanabe; Akihiko Ogura; Masamitsu Iino; Masanobu Kano

  The Journal of physiology, 01 Dec. 2007, Peer-reviewed

  
• Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

  Atsushi Ikeda; Taisuke Miyazaki; Sho Kakizawa; Yasushi Okuno; Soken Tsuchiya; Akira Myomoto; Shin-ya Saito; Tetsuji Yamamoto; Tetsuo Yamazaki; Masamitsu Iino; Gozoh Tsujimoto; Masahiko Watanabe; Hiroshi Takeshima

  Biochemical and biophysical research communications, 23 Nov. 2007, Peer-reviewed

  
• Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells.

  Takeshi Uemura; Sho Kakizawa; Miwako Yamasaki; Kenji Sakimura; Masahiko Watanabe; Masamitsu Iino; Masayoshi Mishina

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 Oct. 2007, Peer-reviewed

  
• Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.

  Shin-ichiro Kina; Tohru Tezuka; Shinji Kusakawa; Yasushi Kishimoto; Sho Kakizawa; Koichi Hashimoto; Miho Ohsugi; Yuji Kiyama; Reiko Horai; Katsuko Sudo; Shigeru Kakuta; Yoichiro Iwakura; Masamitsu Iino; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto

  The European journal of neuroscience, Oct. 2007, Peer-reviewed

  
• Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells.

  Akiko Fujiwara; Sho Kakizawa; Masamitsu Iino

  Neuropharmacology, Jun. 2007, Peer-reviewed

  
• Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.

  Sho Kakizawa; Yasushi Kishimoto; Kouichi Hashimoto; Taisuke Miyazaki; Kazuharu Furutani; Hidemi Shimizu; Masahiro Fukaya; Miyuki Nishi; Hiroyuki Sakagami; Atsushi Ikeda; Hisatake Kondo; Masanobu Kano; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  The EMBO journal, 04 Apr. 2007, Peer-reviewed, Lead author

  
• 成熟脳におけるシナプスの機能維持には神経活動が必要である

  柿澤昌

  日本生理学雜誌 = JOURNAL OF THE PHYSIOLOGICAL SOCIETY OF JAPAN, 01 Jun. 2006

  
• Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF

  K Furutani; Y Okubo; S Kakizawa; M Iino

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2006, Peer-reviewed

  
• Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.

  Sho Kakizawa; Taisuke Miyazaki; Dai Yanagihara; Masamitsu Iino; Masahiko Watanabe; Masanobu Kano

  Proceedings of the National Academy of Sciences of the United States of America, 27 Dec. 2005, Peer-reviewed, Lead author

  
• NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum.

  Shigeyuki Namiki; Sho Kakizawa; Kenzo Hirose; Masamitsu Iino

  The Journal of physiology, 01 Aug. 2005, Peer-reviewed

  
• Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in fragile X syndrome

  SKE Koekkoek; K Yamaguchi; BA Milojkovic; BR Dortland; TJH Ruigrok; R Maex; W De Graaf; AE Smit; F VanderWerf; CE Bakker; R Willemsen; T Ikeda; S Kakizawa; K Onodera; DL Nelson; E Mientjes; M Joosten; E De Schutter; BA Oostra; M Ito; CI De Zeeuw

  NEURON, Aug. 2005, Peer-reviewed

  
• Cross talk between metabotropic and ionotropic glutamate receptor-mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells.

  Yohei Okubo; Sho Kakizawa; Kenzo Hirose; Masamitsu Iino

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 Oct. 2004, Peer-reviewed

  
• PSD-93 Knock-Out Mice Reveal That Neuronal MAGUKs Are Not Required for Development or Function of Parallel Fiber Synapses in Cerebellum

  Aaron W. McGee; J. Rick Topinka; Kouichi Hashimoto; Ronald S. Petralia; Sho Kakizawa; Frederick Kauer; Andrea Aguilera-Moreno; Robert J. Wenthold; Masanobu Kano; David S. Bredt

  The Journal of Neuroscience, 01 May 2001, Peer-reviewed

  
• Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development.

  Sho Kakizawa; Kazuyuki Yamada; Masamitsu Iino; Masahiko Watanabe; Masanobu Kano

  The European journal of neuroscience, Feb. 2003, Peer-reviewed, Lead author

  
• Visualization of IP3 dynamics reveals a novel AMPA receptor-triggered IP3 production pathway mediated by voltage-dependent Ca2+ influx in Purkinje cells

  Y Okubo; S Kakizawa; K Hirose; M Iino

  NEURON, Oct. 2001, Peer-reviewed

  
• EVA樹脂を用いた局所的慢性投与法 - 中枢神経系の発達期可塑性研究への応用例 -

  柿澤昌

  日本比較内分泌学会ニュース = Newsletter of Japan Society for Comparative Endocrinology, Aug. 2001

  
• 小脳の機能発達 (特集 小脳)

  柿澤昌; 田端俊英; 狩野方伸

  神経研究の進歩, Oct. 2000

  
• Critical period for activity-dependent synapse elimination in developing cerebellum

  S Kakizawa; M Yamasaki; M Watanabe; M Kano

  JOURNAL OF NEUROSCIENCE, Jul. 2000, Peer-reviewed, Lead author

  
• ソマトラクチンの生理作用 (総特集 魚類の生育・適応機能と遺伝子)

  柿澤昌

  海洋, Feb. 1998

  
• Possible involvement of somatolactin in the regulation of plasma bicarbonate for the compensation of acidosis in rainbow trout

  S Kakizawa; A Ishimatsu; T Takeda; T Kaneko; T Hirano

  JOURNAL OF EXPERIMENTAL BIOLOGY, Nov. 1997, Peer-reviewed, Lead author

  
• Effects of hypothalamic factors on somatolactin secretion from the organ-cultured pituitary of rainbow trout

  S Kakizawa; T Kaneko; T Hirano

  GENERAL AND COMPARATIVE ENDOCRINOLOGY, Jan. 1997, Peer-reviewed, Lead author

  
• Elevation of plasma somatolactin concentrations during acidosis in rainbow trout (Oncorhynchus mykiss)

  S Kakizawa; T Kaneko; T Hirano

  JOURNAL OF EXPERIMENTAL BIOLOGY, May 1996, Peer-reviewed, Lead author, Corresponding author

  
• EFFECTS OF FEEDING, FASTING, BACKGROUND ADAPTATION, ACUTE STRESS, AND EXHAUSTIVE EXERCISE ON THE PLASMA SOMATOLACTIN CONCENTRATIONS IN RAINBOW-TROUT

  S KAKIZAWA; T KANEKO; S HASEGAWA; T HIRANO

  GENERAL AND COMPARATIVE ENDOCRINOLOGY, May 1995, Peer-reviewed, Lead author, Corresponding author

  
• CHANGES IN PLASMA SOMATOLACTIN LEVELS DURING SPAWNING MIGRATION OF CHUM SALMON (ONCORHYNCHUS-KETA)

  S KAKIZAWA; T KANEKO; T OGASAWARA; T HIRANO

  FISH PHYSIOLOGY AND BIOCHEMISTRY, Apr. 1995, Peer-reviewed, Lead author, Corresponding author

  
• PITUITARY OF COBALT VARIANT OF THE RAINBOW-TROUT SEPARATED FROM THE HYPOTHALAMUS LACKS MOST PARS INTERMEDIAL AND NEUROHYPOPHYSEAL TISSUE

  T KANEKO; S KAKIZAWA; T YADA

  GENERAL AND COMPARATIVE ENDOCRINOLOGY, Oct. 1993, Peer-reviewed

  
• ACTIVATION OF SOMATOLACTIN CELLS IN THE PITUITARY OF THE RAINBOW-TROUT ONCORHYNCHUS-MYKISS BY LOW ENVIRONMENTAL CALCIUM

  S KAKIZAWA; T KANEKO; S HASEGAWA; T HIRANO

  GENERAL AND COMPARATIVE ENDOCRINOLOGY, Sep. 1993, Peer-reviewed, Lead author

  
• GENE-EXPRESSION AND INTRACELLULAR-LOCALIZATION OF SOMATOLACTIN IN THE PITUITARY OF RAINBOW-TROUT

  T KANEKO; S KAKIZAWA; T YADA; T HIRANO

  CELL AND TISSUE RESEARCH, Apr. 1993, Peer-reviewed

  
• C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

  Yuu Miyazaki; Atsuhiko Ichimura; Ryo Kitayama; Naoki Okamoto; Tomoki Yasue; Feng Liu; Takaaki Kawabe; Hiroki Nagatomo; Yohei Ueda; Ichiro Yamauchi; Takuro Hakata; Kazumasa Nakao; Sho Kakizawa; Miyuki Nishi; Yasuo Mori; Haruhiko Akiyama; Kazuwa Nakao; Hiroshi Takeshima

  eLife, 15 Mar. 2022, Peer-reviewed

  
• Signaling Mechanism for Ca2+-Store Regulation in Cerebellar Purkinje Cells

  Sho Kakizawa

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017

  
• Physiological Functions and Cross-talk of Redox Signals in CNS

  Sho Kakizawa

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017

  
• Nitric-oxide induced calcium release: Regulatory mechanism and physiological function

  Sho Kakizawa; Toshiko Yamazawa

  Folia Pharmacologica Japonica, Apr. 2016

  
• Nitric oxide-induced calcium release: Neuronal cell death

  Toshiko Yamazawa; Sho Kakizawa

  Folia Pharmacologica Japonica, Apr. 2016

  
• Molecular Mechanisms and Effects of Aging on Rewriting of Motor Learning and Cerebellar Plasticity

  Sho Kakizawa

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016

  
• Regulation of neuronal function by S-nitrosylation and oxidation

  Sho Kakizawa

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015

  
• Reactive oxygen species inhibits nitric oxide-mediated signaling pathway for synaptic plasticity

  Sho Kakizawa

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• Hole of the C-terminal PDZ binding domain of glutamate receptor delta 2 in synaptic plasticity and climbing fiber wiring

  Takeshi Uemura; Sho Kakizawa; Miwako Yamasaki; Kenji Sakimura; Masahiko Watanabe; Masamitsu Lino; Masayoshi Mishina

  NEUROSCIENCE RESEARCH, 2008

  

Misc.

• Physiological roles of redox signals in relation to synaptic plasticity and brain functions

  Sho Kakizawa

  Folia Pharmacologica Japonica, Nov. 2018

  
• Functional roles of phosphotyrosine adaptor shc in the brain

  Sho Kakizawa

  Folia Pharmacologica Japonica, Aug. 2018

  
• レドックスシグナルによる小脳依存的運動学習の制御

  柿澤昌

  日本酸化ストレス学会学術集会プログラム・抄録集, 2018

  
• Effects of reactive oxygen species on synaptic plasticity in CNS in relation to aging

  Sho Kakizawa

  Folia Pharmacologica Japonica, Nov. 2017

  
• 【脳における細胞内Ca2+ストアの制御機構と脳疾患の新たな治療戦略】脳における新規細胞内カルシウム放出機構一酸化窒素依存的カルシウム放出 神経細胞死への関与

  山澤 徳志子; 柿澤 昌

  日本薬理学雑誌, Apr. 2016

  
• 【脳における細胞内Ca2+ストアの制御機構と脳疾患の新たな治療戦略】脳における新規細胞内カルシウム放出機構一酸化窒素依存的カルシウム放出 制御機構と神経機能への関与

  柿澤 昌; 山澤 徳志子

  日本薬理学雑誌, Apr. 2016

  
• S-nitrosylation of the type 1 ryanodine receptor mediates neuronal cell death

  Yoshinori Mikami; Kazunori Kanemaru; Yasuhiro Oda; Sho Kakizawa; Kazuki Shibata; Hiroki Sugiyama; Ryuta Koyama; Akihiro Ito; Takashi Murayama; Toshiko Yamazawa; Masahiko Watanabe; Yuji Ikegaya; Nobuhito Saito; Takashi Sakurai; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016

  
• 一酸化窒素は1型リアノジン受容体のS-ニトロシル化修飾を介して神経細胞死を誘導する

  三上義礼; 三上義礼; 金丸和典; 大久保洋平; 中畝拓哉; 鈴木純二; 柿澤昌; 村山尚; 柴田和輝; 小山隆太; 伊藤明博; 山澤徳志子; 伊藤雅方; 冨田太一郎; 村上慎吾; 赤羽悟美; 櫻井隆; 池谷裕二; 齊藤延人; 飯野正光; 飯野正光

  日本分子生物学会年会プログラム・要旨集(Web), 2016

  
• Nitric oxide induces neuronal cell death by activation of RyR1 through S-nitrosylation

  Yoshinori Mikami; Kazunori Kanemaru; Yasuhiro Oda; Sho Kakizawa; Hiroki Sugiyama; Kazuki Shibata; Ryuta Koyama; Akihiro Ito; Toshiko Yamazawa; Masahiko Watanabe; Yuji Ikagaya; Nobuto Saito; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015

  
• 新規カルシウム放出機構「一酸化窒素依存的カルシウム放出」と小脳依存性運動学習への関与

  柿澤昌; 岸本泰司; 宮崎太輔; 田中碧; 村山尚; 渡辺雅彦; 飯野正光; 竹島浩

  日本NO学会学術集会プログラム抄録集, 2015

  
• 1型リアノジン受容体のS-ニトロシル化を介した神経細胞死の誘導

  三上義礼; 金丸和典; 小田康弘; 杉山弘樹; 小山隆太; 伊藤明博; 柿澤昌; 山澤徳志子; 村山尚; 渡辺雅彦; 斉藤延人; 飯野正光

  日本薬理学会関東部会プログラム・要旨集, 2014

  
• 非酵素的翻訳後修飾による脳機能制御機構

  柿澤昌

  ブレインサイエンス・レビュー, 2014

  
• 脳内環境をモニターするイメージング 2.内因性チャネルを用いた脳内レドックス環境イメージングと老化・病態脳研究への応用

  柿澤昌

  遺伝子医学MOOK, 2014

  
• Involvement of Nitric oxide-induced calcium release in extinction of cerebellum-dependent motor learning

  Sho Kakizawa; Yasushi Kishimoto; Taisuke Miyazaki; Midori Tanaka; Takashi Murayama; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• Induction of neuronal cell death through S-nitrosylation of the type 1 ryanodine receptor

  Yoshinori Mikami; Kazunori Kanemaru; Yasuhiro Oda; Akihiro Ito; Sho Kakizawa; Toshiko Yamazawa; Nobuhito Saito; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• 活性酸素種によるカルシウム放出チャネル機能阻害の分子メカニズム解明とニューロン機能への影響

  柿澤 昌

  医科学応用研究財団研究報告, Feb. 2013

  
• 活性酸素種によるカルシウム放出チャネル機能阻害の分子メカニズム解明とニューロン機能への影響

  柿澤昌

  医科学応用研究財団研究報告(CD-ROM), 2013

  
• Regulation of Intracellular Calcium Store by a Phosphotyrosine Adaptor ShcB in Cerebellar Purkinje Cells

  Sho Kakizawa; Yasushi Kishimoto; Shinichiro Yamamoto; Kazuko Onga; Kunihiko Yasuda; Ryuichi Sakai; Hiroshi Takeshima; Nozomu Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

  
• ホスホチロシンアダプターShcB欠損マウスにおける小脳機能とプルキンエ細胞内カルシウムシグナル系の阻害

  KAKIZAWA SHO; KISHIMOTO YASUSHI; YAMAMOTO SHIN'ICHIRO; OGAMI KAZUKO; YASUDA KUNIHIKO; SAKAI RYUICHI; TAKESHIMA HIROSHI; MORI NOZOMU

  基礎老化研究, 2013

  
• 一酸化窒素及びカルシウムイメージングにより明らかにされた新規シナプス可塑性とカルシウム動因機構

  柿澤昌

  日本動物学会大会予稿集, 2012

  
• Nitric oxide-induced Ca2+release (NICR) mediated by ryanodine receptor 1 is essential for synaptic plasticity in the cerebellum

  Sho Kakizawa; Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Masahiko Watanabe; Nozomu Mori; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Nitric Oxide-Induced Calcium Release via Ryanodine Receptors

  Toshiko Yamazawa; Sho Kakizawa; Yili Chen; Akihiro Ito; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Osamu Sato; Takashi Sakurai; Katsuji Oguchi; Hiroshi Takeshima; Nobuhito Saito; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Protein Oxidation Inhibits Nitric Oxide-Mediated Signaling Pathway Essential for Synaptic Plasticity

  Sho Kakizawa; Masahiko Shibazaki; Nozomu Mori; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Feb. 2011

  
• 可塑性と臨床 老化脳

  森望; 柿澤昌

  Clinical Neuroscience, 2011

  
• リアノジン受容体を介したNOによるCa²⁺放出の機能的意義

  山澤徳志子; 柿澤昌; 陳毅力; 伊藤明博; 村山尚; 小山田英人; 呉林なごみ; 佐藤治; 櫻井隆; 小口勝司; 竹島浩; 斉藤延人; 飯野正光

  日本循環薬理学会口演要旨集, 2011

  
• Nitric oxide-induced calcium release via ryanodine receptors

  Toshiko Yamazawa; Sho Kakizawa; Hideto Oyamada; Takashi Murayama; Nagomi Kurebayashi; Osamu Sato; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• Nitric oxide-induced calcium release mediated by ryanodine receptors is a novel calcium-releasing mechanism essential for synaptic plasticity in the cerebellum

  Sho Kakizawa; Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Masahiko Watanabe; Nozomu Mori; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Masamitsu Iino

  NEUROSCIENCE RESEARCH, 2011

  
• 一酸化窒素によるリアノジン受容体を介したCa²⁺放出機構

  山澤徳志子; 柿澤昌; 小山田英人; 村山尚; 呉林なごみ; 佐藤治; 櫻井隆; 小口勝司; 竹島浩; 飯野正光

  日本薬理学会関東部会プログラム・要旨集, 2011

  
• 可視化プローブを用いた中枢神経系一酸化窒素動態の解明とシナプス可塑性

  柿澤昌

  分子レベルからの脳機能構築機構の解明 平成16-21年度 No.16070101, 2010

  
• 老齢マウス小脳プルキンエ細胞における酸化ストレスによる神経可塑性の低下

  柿澤昌; 柴崎晶彦; 大神和子; 森望

  基礎老化研究, 2010, Lead author

  
• Nitric oxide is an agonist of intracellular calcium release

  Toshiko Yamazawa; Sho Kakizawa; Hideto Oyamada; Takashi Murayama; Katsuji Oguchi; Takashi Sakurai; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  
• Nitric oxide induced Ca2+ release via the ryanodine receptor

  Toshiko Yamazawa; Sho Kakizawa; Hideto Oyamada; Takashi Murayama; Katsuji Oguchi; Takashi Sakurai; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for long-term depression in the cerebellum

  S. Kakizawa; Y. Kishimoto; K. Hashimoto; T. Miyazaki; K. Furutani; H. Shimizu; M. Fukaya; M. Nishi; H. Sakagami; A. Ikeda; H. Kondo; M. Kano; M. Watanabe; M. Iino; H. Takeshima

  JOURNAL OF NEUROCHEMISTRY, Jul. 2008

  
• 哺乳類小脳回路網の活動依存的な発達・維持機構

  柿澤昌

  解剖学雑誌, 2008

  
• C57BL/6系統由来のES細胞を用いたグルタミン酸受容体δ2の細胞質内領域C末端ドメイン欠損マウスの樹立

  植村健; 柿澤昌; 山崎美和子; 崎村建司; 渡辺雅彦; 飯野正光; 三品昌美

  日本薬理学雑誌, 2008

  
• 一酸化窒素(NO)による細胞内Ca²⁺動員機構

  山澤徳志子; 柿澤昌; 柿澤昌; 小山田英人; 村山尚; 櫻井隆; 小口勝司; 飯野正光

  日本薬理学会関東部会プログラム・要旨集, 2008

  
• GABA_BR-mGluR1シグナル・クロストークによる小脳LTDの増強

  上窪裕二; 上窪裕二; 田端俊英; 柿澤昌; 川上大輔; 渡辺雅彦; 飯野正光; 狩野方伸; 狩野方伸

  日本薬理学雑誌, 2008

  
• Junctophilin-mediated functional coupling of channels essential for cerebellar synaptic plasticity

  Sho Kakizawa; Yasushi Kishimoto; Sin-ya Saito; Kouichi Hashimoto; Taisuke Miyazaki; Kazuharu Furutani; Miyuki Nishi; Hiroyuki Sakagami; Hisatake Kondo; Masanobu Kano; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007

  
• 神経細胞におけるチャネル機能複合体ミクロアセンブリによる後過分極の形成

  TRANSPORTSOME, 2007

  
• Generation of afterhyperpolarization through functional microassembly of ionic channels in neuronal cells

  2007

  
• 新ホルモンハンドブック 「神経栄養因子」

  南江堂, 2007

  
• Metabotropic glutamate receptor-mediated postsynaptic inositol 1,4,5-trisphosphate signaling is required for the maintenance of presynaptic function of parallel fiber-Purkinje cell synapses

  K Furutani; Y Okubo; S Kakizawa; M Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006

  
• Frequency-dependent long-term potentiation of excitatory synapses in the mouse cerebellum regulated by nitric oxide signaling

  S Kakizawa; S Namiki; K Hirose; M Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006

  
• 成熟脳におけるシナプスの機能維持には神経活動が必要である

  日本生理学雑誌, 2006

  
• Involvemement of acitivity in functional maintenance of synapses in mature brain

  2006

  
• Visualization of the range of nitric oxide signaling involved in synapse-specific plasticity in the mouse cerebellum

  S Kakizawa; S Namiki; K Hirose; M Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005

  
• 小脳プルキンエ細胞での平行線維入力誘発性イノシトール1,4,5-三リン酸産生における代謝型グルタミン酸受容体とAMPA受容体のクロストーク(Cross talk between metabotropic glutamate receptor and AMPA receptor in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells)

  大久保 洋平; 柿澤 昌; 廣瀬 謙造; 飯野 正光

  神経化学, Aug. 2004

  
• 成熟マウス小脳におけるシナプス後膜AMPA受容体の活動に依存したシナプス前終末の機能維持(Postsynaptic AMPA receptor activity maintains presynaptic function in the adult cerebellum)

  柿澤 昌; 宮崎 太輔; 飯野 正光; 渡辺 雅彦; 狩野 方伸

  神経化学, Aug. 2004

  
• Parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells is mediated cooperatively by group I metabotropic glutamate receptor and the AMPA receptor

  Y Okubo; S Kakizawa; K Hirose; M Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004

  
• Visualization of inositol 1,4,5-trisphosphate (IP3) dynamics in Purkinje cells reveals a novel AMPA receptor-triggered IP3 production pathway.

  Y Okubo; S Kakizawa; K Hirose; M Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003

  
• Ca2+ dependent protein phosphatase is involved in cerebellar long-term depression.

  A Fujiwara; S Kakizawa; M Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003

  
• Trophic effect of insulin-like growth factor I on the climbing fiber-Purkinje cell synapse during postnatal development of the mouse cerebellum

  S Kakizawa; K Yamada; M Watanabe; M Kano; M Iino

  JAPANESE JOURNAL OF PHARMACOLOGY, 2002

  
• IP3可視化によって明らかになった小脳プルキンエ細胞におけるCa2+流入依存性IP3産生

  大久保 洋平; 柿澤 昌; 廣瀬 謙造; 飯野 正光

  神経化学, Sep. 2001

  
• インシュリン様成長因子Iのマウス小脳登上線維-プルキンエ細胞シナプスの生後発達に及ぼす影響

  柿澤 昌; 山田 和之; 渡辺 雅彦; 狩野 方伸

  神経化学, Sep. 2001

  
• EVA樹脂を用いた局所的慢性投与法－中枢神経系の発達期可塑性研究への応用例

  柿澤 昌

  日本比較内分泌学会ニュース, 2001

  
• Local and chronic application of drugs using ethylene-vinyl acetate copolymer (ELVAX)

  Comparative Endocrinology, 2001

  
• 【小脳】小脳の機能発達

  柿澤 昌; 田端 俊英; 狩野 方伸

  神経研究の進歩, Oct. 2000

  
• 小脳

  柿澤昌; 狩野 方伸

  脳神経科学イラストレイテッド 第２章 ５．森寿、真鍋俊也、渡辺雅彦、岡野栄之、宮川剛／編, 2000, Peer-reviewed, Invited

  
• 脳神経科学イラストレイテッド 「小脳」

  羊土社, 2000

  
• Maturation of Purkinje cell functions and elimination of surplus climbing fiber synapses during cerebellar development

  Advances in Neurological Sciences, 2000

  
• 神経伝達と可塑性 小脳発達における神経活動依存性シナプス成熟機構

  狩野 方伸; 橋本 浩一; 柿澤 昌

  日本医学会総会会誌, Dec. 1999

  
• マウス小脳登上線維の生後発達の神経活動依存性と臨界期

  柿澤 昌; 渡辺 雅彦; 井上 芳郎; 狩野 方伸

  神経化学, Sep. 1998

  
• 小脳における回路形成,可塑性,計算論 発達期小脳における過剰な登上線維シナプス排除のメカニズム

  狩野 方伸; 柿澤 昌; 橋本 浩一

  神経化学, Sep. 1998

  
• Possible mechanisms for climbing fiber elimination during postnatal cerebellar development

  HASHIMOTO Kouichi; KAKIZAWA Sho; KANO Masanobu

  日本分子生物学会年会プログラム・講演要旨集, 1998, Peer-reviewed, Invited

  
• Physiological functions of somatolactin, a novel hormone isolated from pituitary

  Ocean Research, 1998

  
• ソマトラクチンの生理作用

  海洋, 1998

  
• シナプスをめぐるシグナリング 1.受容体 1型インシュリン様成長因子受容体

  柿澤昌

  生体の科学, 2010

  

Presentations

• Disparity of age-dependent decline in calcium-release channel responses to nitric oxide and calcium in central neuron

  Sho Kakizawa; Nozomu Mori

  第45回日本基礎老化学会大会, 28 Jul. 2022

  
• 活性酸素依存的なカルシウム恒常性システムの調節を介した小脳機能

  柿澤 昌

  第94回日本薬理学会年会シンポジウム, 10 Mar. 2021, Invited

  
• Ca2+とレドックスシグナルによる小脳シナプス可塑性の極性決定

  柿澤 昌; 遠藤 昌吾

  生理学研究所研究会「細胞システム理解のためのシグナル応答原理解明の最前線」, 04 Sep. 2020

  
• レドックスシグナルによる細胞内Ca2+放出系の制御とシナプス可塑性

  柿澤 昌

  第93回日本薬理学会年会シンポジウム, 16 Mar. 2020

  
• レドックスシグナルによる小脳機能制御

  柿澤 昌; 遠藤 昌吾

  生理学研究所研究会「シグナル動態の可視化と操作に基づく多階層機能解析の新展開」, 20 Sep. 2019

  
• Involvement of ROS - 8-nitro-cGMP signals in cerebellar long-term depression

  Sho Kakizawa; Shogo Endo

  NEURO2019, 28 Jul. 2019

  
• Construction and integration of the All-in-One type single double-conditional shRNA expression vectors for spatio-temporal gene and/or cell targeting

  Hideto Oyamada; Yoko Ao; Yoshiko Kudo; Tomoyuki Matsuoka; Reiko Okamoto; Takashi Murayama; Toshiko Yamazawa; Sho Kakizawa; Tatsunori Oguchi; Atsushi Michael Kimura; Taro Yasumoto; Yukiko Mori; Mayumi Tsuji; Katsuji Oguchi; Yuji Kiuchi

  NEURO2019, 26 Jul. 2019

  
• Possible Involvement ROS in Physiological Aging through Inhibition of Protein S-nitrosylation of calcium channel

  sho kakizawa

  The 19th Korea-Japan Joint Symposium for Basic Gerontology, 28 Jun. 2019, Invited

  
• 活性酸素種(ROS)によるS-ニトロシル化阻害を介したマウス小脳の生理的老化

  柿澤 昌

  第92回日本薬理学会年会シンポジウム, 15 Mar. 2019, Invited

  
• 白紙人材の育成を目指す京都大学薬学部における初年次アクティブラーニング科目「SGD演習」の試み

  高須 清誠; 山下 富義; 津田 真弘; 柿澤 昌; 矢野 義明; 長沼 祥太郎; 松下 佳代

  第25回大学教育研究フォーラム, Mar. 2019

  
• 記憶の維持・消去そして老化－成熟後の神経回路網における機能制御とシグナリング機構.

  柿澤 昌

  第190回 東京大学生命環境科学系セミナー, 25 Jan. 2019, Invited

  
• 活性酸素シグナルによる小脳シナプス機能制御

  柿澤 昌; 遠藤 昌吾

  生理学研究所 研究会「シグナル動態の可視化と操作に基づく多階層機能解析の新展開」, Sep. 2018, Invited

  
• Involvement of ROS/8-nitro-cGMP signals in cerebellar synaptic plasticity in mice

  sho kakizawa; shogo endo

  第91回日本薬理学会年会・第18 国際薬理学・臨床薬理学会議, Jul. 2018

  
• Involvement of redox signals in cerebellar-dependent motor learning

  Sho Kakizawa

  Joint Meeting of The 71th Annual Meeting of Society of Free Radical Research Japan and The 18th Annual Meeting of NO Society of Japan, 17 May 2018, Invited

  
• Involvement of Nitric Oxide-Induced Calcium Release (NICR) through Type 1 Ryanodine Receptor in Extinction of Cerebellum-Dependent Motor Learning.

  Kakizawa S; Kishimoto Y; Miyazaki T; Mikami Y; Murayama T; Nagai M; Yamazawa T; Adachi-Akahane S; Watanabe M; Iino M

  The 20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease (CaBP20), 22 Oct. 2017

  
• Physiological Functions and Cross-talk of Redox Signals in CNS

  sho kakizawa

  第90回日本薬理学会年会, 17 Mar. 2017, Invited

  
• Signaling Mechanism for Ca2+-Store Regulation in Cerebellar Purkinje Cells

  sho kakizawa

  第90回日本薬理学会年会, 15 Mar. 2017, Invited

  
• Involvement of Cerebellar LTP induced by Nitric Oxide-Induced Ca2+ Release in Extinction of Eyeblink Conditioning

  sho kakizawa

  FENS Forum 2016, Jul. 2016

  
• 小脳依存的運動学習の書換えと加齢の影響

  柿澤 昌

  第89回日本薬理学会年会シンポジウム, Mar. 2016, Invited

  
• 新規カルシウム放出機構「一酸化窒素依存的カルシウム放出」と小脳依存性運動学習への関与

  柿澤 昌

  第15回日本NO学会学術集会, 26 Jun. 2015

  
• S-nitrosylation-mediated regulation of neuronal function

  柿澤 昌

  第88回日本薬理学会年会シンポジウム, Mar. 2015

  
• 1型リアノジン受容体のS‐ニトロシル化を介した神経細胞死の誘導

  MIKAMI YOSHINORI; KANAMARU KAZUNORI; ODA YASUHIRO; SUGIYAMA HIROKI; KOYAMA RYUTA; ITO AKIHIRO; KAKIZAWA AKIRA; YAMAZAWA TOSHIKO; MURAYAMA TAKASHI; WATANABE MASAHIKO; SAITO NOBUHITO; IINO MASAMITSU

  日本薬理学会関東部会プログラム・要旨集, 2014

  
• NO-induced calcium release (NICR) と神経細胞死

  三上 義礼; 金丸 和典; 小田 康弘; 杉山 弘樹; 小山 隆太; 伊藤 明博; 柿澤 昌; 山澤 徳志子; 村山 尚; 渡辺 雅彦; 池谷 裕二; 斉藤 延人; 飯野 正光

  生理学研究所研究会「新規シグナル伝達分子とその生理学的可能性」, 2014

  
• ホスホチロシンアダプターShcB欠損マウスにおける小脳機能とプルキンエ細胞内カルシウムシグナル系の阻害

  KAKIZAWA SHO; KISHIMOTO YASUSHI; YAMAMOTO SHIN'ICHIRO; OGAMI KAZUKO; YASUDA KUNIHIKO; SAKAI RYUICHI; TAKESHIMA HIROSHI; MORI NOZOMU

  基礎老化研究, 12 May 2013

  
• 内因性チャネルを用いた脳内レドックス環境イメージングと老化・病態脳研究への応用

  柿澤 昌

  平成25年度「脳内環境」夏の領域班会議シンポジウム, 2013

  
• 一酸化窒素及びカルシウムイメージングにより明らかにされた新規シナプス可塑性とカルシウム動因機構

  KAKIZAWA SHO

  日本動物学会大会予稿集, 20 Aug. 2012

  
• Regulation of synaptic function by reactive oxygen species in young and aged CNS

  Kakizawa S

  The 4th AACL Meeting, Nov. 2011, Invited

  
• Protein oxidation inhibits nitric oxide-dependent signaling pathway essential for synaptic plasticity in the CNS

  Kakizawa S

  The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects, Apr. 2011, Invited

  
• Protein oxidation inhibits nitric oxide-induced signaling pathway essential for synaptic plasticity in the CNS

  Kakizawa S

  The 3rd AACL Meeting, Feb. 2011, Invited

  
• 一酸化窒素によるリアノジン受容体を介したCa²⁺放出機構

  YAMAZAWA TOSHIKO; KAKIZAWA AKIRA; OYAMADA HIDETO; MURAYAMA TAKASHI; KUREBAYASHI NAGOMI; SATO OSAMU; SAKURAI TAKASHI; OGUCHI KATSUJI; TAKESHIMA HIROSHI; IINO MASAMITSU

  日本薬理学会関東部会プログラム・要旨集, 2011

  
• リアノジン受容体を介したNOによるCa²⁺放出の機能的意義

  YAMAZAWA TOSHIKO; KAKIZAWA MASASHI; CHIN KIRYOKU; ITO AKIHIRO; MURAYAMA TAKASHI; OYAMADA HIDETO; KUREBAYASHI NAGOMI; SATO OSAMU; SAKURAI TAKASHI; OGUCHI KATSUJI; TAKESHIMA HIROSHI; SAITO NOBUHITO; IINO MASAMITSU

  日本循環薬理学会口演要旨集, 2011

  
• 一酸化窒素シグナル依存的可塑性と活性酸素種による制御

  柿澤 昌

  第84回日本生化学会大会フォーラム, 2011

  
• 一酸化窒素シグナル依存的シナプス可塑性と活性酸素種による制御

  柿澤 昌

  第84回日本薬理学会年会シンポジウム, 2011

  
• 老齢マウス小脳プルキンエ細胞における酸化ストレスによる神経可塑性の低下

  KAKIZAWA SHO; SHIBAZAKI MASAHIKO; OGAMI KAZUKO; MORI NOZOMU

  基礎老化研究, 28 May 2010

  
• 中枢ニューロンにおける受容体アダプター分子によるイオン輸送体機能制御と生理学的意義

  柿澤 昌

  トランスポーター研究会第3回九州部会シンポジウム, 2009

  
• 哺乳類小脳回路網の活動依存的な発達・維持機構

  KAKIZAWA AKIRA

  解剖学雑誌, Mar. 2008

  
• 一酸化窒素(NO)による細胞内Ca²⁺動員機構

  YAMAZAWA TOSHIKO; KAKIZAWA MASASHI; OYAMADA HIDETO; MURAYAMA HISASHI; SAKURAI TAKASHI; OGUCHI KATSUJI; IINO MASAMITSU

  日本薬理学会関東部会プログラム・要旨集, 2008

  
• 脳は使わないと衰える？−小脳興奮性シナプスの活動依存的維持機構

  柿澤 昌

  第４回長崎ニューロサイエンス研究会, 2008

  
• C57BL/6系統由来のES細胞を用いたグルタミン酸受容体δ2の細胞質内領域C末端ドメイン欠損マウスの樹立

  UEMURA KEN; KAKIZAWA AKIRA; YAMAZAKI MIWAKO; SAKIMURA KENJI; WATANABE MASAHIKO; IINO MASAMITSU; MISHINA MASAYOSHI

  日本薬理学雑誌, 01 Jan. 2008

  
• GABA_BR‐mGluR1シグナル・クロストークによる小脳LTDの増強

  KAMIKUBO YUJI; TABATA TOSHIHIDE; KAKIZAWA AKIRA; KAWAKAMI DAISUKE; WATANABE MASAHIKO; IINO MASAMITSU; KANO MASANOBU

  日本薬理学雑誌, 01 Jan. 2008

  
• Maintenance of presynaptic function by postsynaptic IP3 signaling via BDNF

  柿澤 昌; 古谷 和春; 大久保 洋平; 飯野 正光

  第85回日本生理学会大会シンポジウム, 2008

  
• Activity-dependent maintenance of synaptic function mediated by glutamate receptors

  Kakizawa S

  The Cerebellar Colloquim, 2007, Invited

  
• 活動依存的な小脳興奮性シナプスの機能維持とグルタミン酸受容体の関与

  柿澤 昌

  生理学研究所研究会 「シナプス形成と可塑性機構獲得の統合的理解へ向けた学際的アプローチ」, 2006

  
• Visualization and manipulation of the signaling systems in the CNS using Sindbis viral vectors

  柿澤 昌

  第29回日本神経科学会シンポジウム, 2006

  
• 一酸化窒素(NO)シグナルによる神経活動デコーディングとシナプス可塑性：NO可視化プローブを用いたアプローチ

  柿澤 昌; 並木 繁行; 廣瀬 謙造; 飯野 正光

  生理学研究所研究会「細胞内シグナル伝達機構の多角的・包括的理解」, 2004

  
• 神経活動依存的シナプス機能維持とレトログレードメッセンジャー

  柿澤 昌

  第81回日本生理学会大会シンポジウム, 2004

  
• 小脳機能的回路網形成における非対称性の発達と臨界期

  柿澤 昌

  日本動物学会第73回大会シンポジウム, 2002

  
• 発達期小脳における過剰な登上線維シナプスの神経活動依存性除去機構

  狩野 方伸; 橋本 浩一; 柿澤 昌; 前島 隆司

  第78回日本生理学会シンポジウム, 2001

  
• 発達期小脳における選択的シナプス除去のメカニズム

  狩野 方伸; 柿澤 昌; 橋本 浩一

  第23回日本神経科学大会・第10回日本神経回路学会大会合同大会シンポジウム, 2000

  
• 発達期小脳における過剰な登上線維排除の機構

  橋本 浩一; 柿澤 昌; 狩野 方伸

  第21回日本分子生物学会, 01 Dec. 1998

  
• Elimination of multiple climbing fiber innervation of Purkinje cells during postnatal cerebellar development

  狩野 方伸; 柿澤 昌; 橋本 浩一

  第21回日本神経科学・第41回日本神経化学合同大会シンポジウム, 1998

  
• Possible involvement of somatolactin in acid-base regulation in fish

  Kaneko T; Kakizawa S; Hirano T

  The 3rd International Symposium on Fish Endocrinology, 1996

  
• Somatolactin and calcium regulation in fish

  Kaneko T; Kakizawa S; Arakawa E; Hirano T

  Society for Experimental Biology, Canterbury Meeting, 1993

  
• C型ナトリウム利尿ペプチドは軟骨細胞内Ca2+シグナル経路を活性化し骨伸長を促進する

  岡本 直樹; 市村 敦彦; 宮崎 侑; 北山 諒; 安江 智己; 劉 楓; 川邊 隆彰; 長友 宏樹; 柿澤 昌; 西 美幸; 竹島 浩

  日本薬学会第142年会, 28 Mar. 2022

  
• Involvement of ROS in Aging and Plasticity of Cerebellar Synapses

  Sho Kakizawa

  The 99th Annual Meeting of the Physiological Society of Japan, 16 Mar. 2022, Invited

  
• Involvement of 8-nitro-cGMP - ERK signals in the induction of long-term depression in the mouse cerebellum

  Sho Kakizawa; Tomoko Arasaki; Yasushi Satoh; Shogo Endo

  The 95th Annual Meeting of the Japanese Pharmacological Society, 07 Mar. 2022

  
• C-type natriuretic peptide stimulates bone growth by potentiating autonomic Ca2+ entry in growth plate chondrocytes

  Yu Miyazaki; Atsuhiko Ichimura; Ryo Kitayama; Naoki Okamoto; Tomoki Yasue; Feng Liu; Takaaki Kawabe; Hiroki Nagatomo; Miyuki Nishi; Sho Kakizawa; Hiroshi Takeshima

  The 95th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2022

  
• Involvement of redox modification of ryanodine receptor in motor learning and brain aging

  Sho Kakizawa

  The 64th Annual Meeting of the Japanese Society for Neurochemistry, 30 Sep. 2021, Invited

  

Books and Other Publications

• Handbook of Hormones 2nd Ed. "Elabera"

  Sho Kakizawa, Contributor, pp.529-531

  Elsevier, Jul. 2021

  
• Handbook of Hormones 2nd Ed. "Apelin"

  Sho Kakizawa, Contributor, pp.525-527

  Elsevier, Jul. 2021

  
• Handbook of Hormones 2nd Ed. "Neurotrophin-3"

  Sho Kakizawa, Contributor, pp.483-485

  Elsevier, Jul. 2021

  
• Handbook of Hormones 2nd Ed. "Brain-derived neurotrophic factor"

  Sho Kakizawa, Contributor, pp.479-482

  Elsevier, Jul. 2021

  
• Handbook of Hormones 2nd Ed. "Nerve growth factor"

  Sho Kakizawa, Contributor, pp.475-478

  Elsevier, Jul. 2021

  
• Handbook of Hormones 2nd Ed. "Neurotrophin family"

  Sho Kakizawa, Contributor, pp.471-473

  Elsevier, Jul. 2021

  
• Handbook of Hormones 2nd Ed. "Somatolactin"

  Sho Kakizawa, Contributor, pp.207-209

  Elsevier, Jul. 2021

  
• 脳科学辞典（改訂書籍版）「ジャンクトフィリン」

  柿澤 昌, Contributor

  東京大学出版会, 2021

  
• 脳科学辞典（改訂書籍版）「リアノジン受容体」

  柿澤 昌, Contributor

  東京大学出版会, 2021

  
• Handbook of Intrabrain Circumstance "Redox Signal"

  Sho Kakizawa, Contributor, pp. 98-99

  Medical Do, Mar. 2017, Not refereed

  
• Essentials of the Cerebellum "Nitric Oxide"

  Kakizawa S

  Springer, 2016, Not refereed

  
• Aging Mechanisms: Cells, Metabolism, Longevity, and Brain Aging "Critical Roles of Oxidative Signals in Age-Related Decline of Cerebellar Synaptic Plasticity"

  Kakizawa S; Mori N

  Springer, 2015, Not refereed

  
• Hormone Handbook "Apelin"

  Kakizawa S

  Elsevier, 2015, Not refereed

  
• Hormone Handbook "Somatolactin"

  Kakizawa S

  Elsevier, 2015, Not refereed

  
• Posttranslational Modification of Intercellular Messenger Systems

  Kakizawa S; Kaiya H; Takahashi A

  Frontiers Media SA (E-book), 2014, Not refereed

  
• 遺伝子医学MOOK26号 脳内環境−恒常性維持機構の破綻と病気 「内因性チャネルを用いた脳内レドックス環境イメージングと老化・病態脳研究への応用」

  柿澤 昌

  メディカルドゥ, 2014, Not refereed

  
• ブレインサイエンス・レビュー2014 「非酵素的翻訳後修飾による脳機能制御機構」

  柿澤 昌

  クバプロ, 2014, Not refereed

  
• 脳科学辞典 「ジャンクトフィリン」

  柿澤 昌

  Web辞典, 2013, Not refereed

  
• 脳科学辞典 「リアノジン受容体」

  柿澤 昌

  Web辞典, 2012, Not refereed

  
• 新 医歯薬学系学生のための基礎生命科学 「8章 恒常性」

  柿澤 昌

  京都廣川書店, 2011, Not refereed

  
• トランスポートソームの世界 「結合膜構造とチャネルミクロアセンブリ」

  竹島 浩; 柿澤 昌

  京都廣川書店, 2011, Not refereed

  
• トランスポートソームの世界 「小胞体Ca2+放出チャネルファミリー」

  竹島 浩; 柿澤 昌

  京都廣川書店, 2011, Not refereed

  
• トランスポートソームの世界 「Ca2+シグナルとイオンチャネル 総論」

  竹島 浩; 柿澤 昌

  京都廣川書店, 2011, Not refereed

  
• 新ホルモンハンドブック 「神経栄養因子」

  柿澤 昌

  南江堂, 2007, Not refereed

  
• 脳神経科学イラストレイテッド 「小脳」

  柿澤 昌; 狩野 方伸

  羊土社, 2000, Not refereed

  

External funds: Kakenhi

• Roles of 8-nitro-cGMP pathway as the coincident detector for memory formation.

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields

  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

  遠藤 昌吾

  From 09 Jul. 2021, To 31 Mar. 2023, Granted

  活性酸素種;記憶;小脳;シグナル伝達;一酸化窒素;記憶・学習;連合性;可塑性;長期抑圧

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19752/
• 運動の学習に伴う脳内誤差信号の情報表現の変容とそれを基盤とした学習指導方法の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 59030:Physical education, and physical and health education-related

  The University of Tokyo

  柳原 大

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  歩行;スプリットベルトトレッドミル;適応;運動学習;小脳;下オリーブ核;マウス;ラット;肢間協調;登上線維;誤差情報

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03339/
• Reactive oxygen species; physiological role in the brain

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields

  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

  Shogo Endo

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  ROS;8-nitro-cGMP;小脳;運動記憶;神経可塑性;LTP/LTD;NO;活性酸素種;記憶;プルキンエ細胞;cGMP;一酸化窒素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22834/
• 活性酸素シグナルの脳機能への正負の作用機構の解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46030:Function of nervous system-related

  Kyoto University

  柿澤 昌

  From 01 Apr. 2019, To 31 Mar. 2023, Granted

  活性酸素;一酸化窒素;シナプス;小脳;カルシウム;長期増強;長期抑圧;可塑性;老化;運動学習;レドックスシグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06955/
• Regulation of Cerebellar Function by Redox Modification of Calcium-Release Channel

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Sho Kakizawa

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  一酸化窒素;活性酸素;レドックスシグナル;翻訳後修飾;カルシウム放出;リアノジン受容体;小脳;運動学習;カルシウム;シナプス;長期増強;記憶学習;シナプス可塑性;プルキンエ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06774/
• 内因性チャネルを用いた脳内レドックス環境イメージングと老化・病態脳研究への応用

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  柿澤 昌

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  酸化シグナル;ニューロン;小脳;プルキンエ細胞;カルシウム;リアノジン受容体;一酸化窒素;イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24111528/
• Identification of cysteine involved in oxidation-induced inhibition of channel function

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Sho KAKIZAWA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  酸化シグナル;老化;翻訳後修飾;チャネル;イオンチャネル;カルシウム;一酸化窒素;リアノジン受容体;神経科学;脳・神経

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659037/
• Positive and negative regulations of cytoskeletal dynamism and neuronal lifespan

  Grant-in-Aid for Scientific Research (B)

  Nagasaki University

  Nozomu MORI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  老化;寿命;脳;神経可塑性;シグナル伝達;蛋白質凝集;アセチル化;神経;可塑性;オートファジー;微小管;蛋白凝集

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300121/
• Physiological functions of nitric-oxide induced calcium-release in central nervous systems

  Grant-in-Aid for Scientific Research (C)

  Nagasaki University

  Sho KAKIZAWA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  一酸化窒素;カルシウム;小脳;プルキンエ細胞;シナプス可塑性;S-ニトロシル化;プルキン工細胞;酸化シグナル;老化;酸化ストレス;イオンチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500333/
• 小胞体トランスポートソームにおけるシグナルクロストークと神経機能制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Nagasaki University

  柿澤 昌

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  小胞体;カルシウム;シナプス可塑性;小脳;プルキンエ細胞;アダプター分子;トランスポートソーム;一酸化窒素;イオンチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20056007/
• The influence of physical activity on the cerebellar synaptic function and the motor skill in adult and developmental stages

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Yanagihara DAI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  小脳;下オリーブ核;運動学習;運動スキル;運動習慣;シナプス形成;脳・神経

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500494/
• Research on the fundamental molecules in relation to controlling brain aging : From neuronal cytoskeleton regulation to neuronal longevity control

  Grant-in-Aid for Scientific Research (B)

  Nagasaki University

  Nozomu MORI

  From 01 Apr. 2007, To 31 Mar. 2010, Project Closed

  神経可塑性;シグナル伝達;神経変性;アクチン;微小管;老化;ニューロン;リン酸化;ヒストン脱アセチル化酵素;可塑性;スパイン;アクチン骨格;HOAC;Shc;海馬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300130/
• Signaling mechanisms involved in novel synaptic plasticity in excitatory inputs in the cerebellum

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Sho KAKIZAWA

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  小脳;シナプス;可塑性;カルシウム;薬理学;シグナル伝達;神経科学;生理学;脳・神経;一酸化窒素, cerebellum;synapse;plasticity;calcium

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500290/
• 可視化プローブを用いた中枢神経系一酸化室素動態の解明とシナプス可塑性

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  柿澤 昌

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  脳科学;シグナル伝達;イメージング;機能分子;シナプス可塑性;小脳;一酸化窒素;カンナビノイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17024015/
• 小脳興奮性シナプスの発達期可塑性におけるカルシニューリンの役割

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  柿澤 昌

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  カルシニューリン;シナプス;発達;小脳;登上線維;可塑性;遺伝子導入;ウィルス;プルキンエ細胞;発達期可塑性;FK-506;慢性投与

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15790130/
• インシュリン様成長因子-1のマウス登上線維シナプスの生後発達に及ぼす影響

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  柿澤 昌

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  IGF-I;小脳;シナプス;プルキンエ細胞;登上線維;発達;活動依存性;成長因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13770042/
• 細胞内シグナルフローの可視化解析

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  The University of Tokyo

  飯野 正光

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  カルシウム;一酸化窒素;リン酸化;ミオシン;イノシトール三リン酸;イメージング;プルキンエ細胞;血管;リシ酸化;NFAT

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12002003/
• マウス小脳登上線維シナプスの発達に伴う変化とインターロイキン6の影響

  Grant-in-Aid for Encouragement of Young Scientists (A)

  理化学研究所

  柿澤 昌

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  小脳;登上線維;シナプス;生後発達;インターロイキン6;テトロドトキシン;Elvax;活動依存性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09780756/
• 自閉症における運動学習の障害と軽運動による相乗的改善効果に関わる神経機構の解明

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields

  The University of Tokyo

  柳原 大

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  自閉症スペクトラム障害;運動スキル;歩行適応制御;mTOR;FMR1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19704/

External funds: others

• 活性酸素種の神経活動依存的な産生と記憶学習への関与

  清水免疫学・神経科学財団 研究助成

  From 2019, To 2021

  柿澤　昌
• コーヒー成分の加齢に伴う脳機能低下に対する抑制作用とその分子機構の解明

  全日本コーヒー協会2018年研究助成

  From 01 Apr. 2018, To 31 Mar. 2019

  柿澤　昌
• 酸化シグナルによるカルシウム放出チャネル阻害の分子機構と老化への関与

  清水免疫学・神経科学財団研究助成

  From 2014, To 2016

  柿澤　昌
• リアノジン受容体のS-ニトロシル化を介した神経機能制御機構の解明

  島原科学振興会研究助成金

  From 2014, To 2015

  柿澤　昌
• 非酵素的翻訳後修飾による脳機能制御機構

  ブレインサイエンス振興財団第26回研究助成

  From 2011, To 2012

  柿澤　昌
• 活性酸素種によるカルシウム放出チャネル機能阻害の分子メカニズム解明とニューロン機能への影響

  医科学応用研究財団調査研究助成金

  From 2010, To 2011

  柿澤　昌
• 中枢神経系機能への活性酸素種の作用機序と抗老化創薬への応用

  持田記念医学薬学振興財団研究助成

  From 2010, To 2011

  柿澤　昌
• レドックスシグナル依存的カルシウム放出とその生理的役割の解明

  武田科学振興財団医学系研究奨励(基礎)

  From 2009, To 2010

  柿澤　昌
• 成熟脳における退縮シナプスの回復とシグナリング機構

  成茂神経科学研究助成基金

  From 2008, To 2008

  柿澤　昌
• マウス小脳登上線維-プルキンエ細胞シナプスの活動依存的機能調節と運動協調への関与

  豊田理化学研究所研究嘱託

  From 2001, To 2002

  柿澤　昌
• (戦略的基礎研究推進事業研究員により応募資格なし)

  From 1999, To 2000

  代表

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Biological Chemistry 1 (Biomolecules)

  C201, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  C906, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  A906, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Biological Chemistry 1 (Biomolecules)

  A201, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  SGD Classes for Pharmaceutical Research

  C501, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  生物化学Ｉ（物質生化学）

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習III

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  生物化学１（物質生化学）

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習４

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  BiochemistryI(Bio molecules)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory IV: Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Biological Chemistry 1 (Biomolecules)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Biological Chemistry 1 (Biomolecules)

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Biological Chemistry 1 (Biomolecules)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Biological Chemistry 1 (Biomolecules)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Biological Chemistry 1

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Biological Chemistry 1 (Biomolecules)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Biological Chemistry 1

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Biological Chemistry 1 (Biomolecules)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部

Administration

School management (title, position)

• From 01 May 2016, To 31 Mar. 2019

  国際高等教育院 企画評価専門委員会 人文・社会科学部会2 委員
• From 01 Apr. 2019, To 31 Mar. 2020

  国際高等教育院 企画評価専門委員会 人文・社会科学部会2 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  国際高等教育院 企画評価専門委員会 人文・社会科学部会2 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  国際高等教育院 企画評価専門委員会 人文・社会科学部会2 委員
• From 01 Apr. 2021, To 31 Mar. 2023

  組換えＤＮＡ実験安全委員会 委員

Faculty management (title, position)

• From 01 Apr. 2011, To 31 Mar. 2023

  図書委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2023

  動物実験委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2022

  教務委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2023

  環境・安全衛生委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2023

  情報システム委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2017

  ＲＩ管理委員会　委員

Academic, Social Contribution

Committee Memberships

• From Apr. 2021, To Present

  理事、学術交流委員長, 日本基礎老化学会
• From Apr. 2015, To Present

  評議員, 日本基礎老化学会
• From Mar. 2015, To Present

  評議員, 日本生理学会
• From Apr. 2006, To Present

  学術評議員, 日本薬理学会
• From Dec. 2018, To Mar. 2021

  編集委員, 日本基礎老化学会
• From May 2021, To Present

  第45回大会プログラム委員長, 日本基礎老化学会