Kyoto University, Medical Innovation Center, 特定准教授(PI)
From 2017, To 2018
京都大学 医学研究科・神経生物学(伊佐 正研究室), 講師
From 2016, To 2017
Kyoto University, 医学研究科・神経生物学 (伊佐 正研究室), 助教
From 2013, To 2016
National Institute for Physiological Sciences, Assistant Professor
From 2010, To 2013
Massachusetts Institute of Technology, Media Lab (Edward Boyden's group), Postdoc
From 2008, To 2010
Postdoc, University of Maryland, Department of Anatomy and Neurobiology (Geoffrey Schoenbaum's lab)
To 2007
Kyoto University (MD)
Profile
Profile
分子神経生物学、動物心理学、連合学習理論、In vivo 電気生理学、光遺伝学、イメージング、数理モデリングなどを駆使し、げっ歯類(特にラット)をモデルとして、意欲や動機づけ、注意の神経基盤の基礎研究を行っています。特に、認知行動課題を遂行中のげっ歯類の、ドーパミン神経回路などの、サブ秒単位のダイナミックな役割について研究しています。
Motivation is an important brain function to achieve one's goals in work, social relationships, and so on. On the other hand, loss of motivation is a common syndrome observed across many psychiatric diseases. However, the neural basis of motivation is not well understood. This is why the treatment of loss of motivation has been difficult. Our research aims to address the neural basis of motivation by multidisciplinary approach utilizing behavioral models based on animal phycology, genetic methods such as genetically engineered rodents, and methods to measure neural activity such as electrophysiology and calcium imaging. We believe our research will also lead to better understanding of the mechanisms and treatments of loss of motivation.
Research Interests
意欲
アセチルコリン
動機づけ
Dopamine
前頭前野
注意
連合学習
動物心理学
包括脳ネットワーク
Optogenetics
Cognition
分子生物学
Neuroscience
Research Areas
Humanities & social sciences, Experimental psychology
Life sciences, Neuroscience - general
Life sciences, Basic brain sciences
Papers
Dopamine error signal to actively cope with lack of expected reward.
EUROPEAN JOURNAL OF NEUROSCIENCE, May 2017, Peer-reviewed, Corresponding author
Noninvasive optical inhibition with a red-shifted microbial rhodopsin
Amy S. Chuong; Mitra L. Miri; Volker Busskamp; Gillian A. C. Matthews; Leah C. Acker; Andreas T. Sorensen; Andrew Young; Nathan C. Klapoetke; Mike A. Henninger; Suhasa B. Kodandaramaiah; Masaaki Ogawa; Shreshtha B. Ramanlal; Rachel C. Bandler; Brian D. Allen; Craig R. Forest; Brian Y. Chow; Xue Han; Yingxi Lin; Kay M. Tye; Botond Roska; Jessica A. Cardin; Edward S. Boyden