Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 細胞誘導制御学, 教授
• Graduate School of Medicine, 医科学専攻 細胞誘導制御学, 教授

Concurrent Affiliation

• Center for iPS Cell Research and Application (CiRA), iPS細胞研究所 臨床応用研究部門, 教授

Professional Memberships

• The American Society for Bone and Mineral Research
• 米国骨代謝学会
• 日本結合組織学会
• 日本軟骨代謝学会
• 日本骨代謝学会
• 日本リウマチ学会
• 日本整形外科学会
• The American Society for Bone and Mineral Research

Academic Degree

• 博士（医学）(大阪大学)

Academic Resume (Graduate Schools)

• 大阪大学, 大学院医学研究科博士課程外科系専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 大阪大学, 医学部医学科, 卒業

Research History

• From Jul. 2021, To Present

  Graduate School of Medicine, Osaka University, Department of Biochemistry and Molecular Biology, Professor
• From Jun. 2011, To Present

  Kyoto University, iPS細胞研究所, 教授
• From Apr. 2007, To May 2011

  Osaka University Graduate School of Medicine, 医学系研究科 骨・軟骨形成制御学, 独立准教授
• From Aug. 2002, To Mar. 2007

  大阪大学大学院, 医学系研究科 整形外科, 助手
• From Apr. 1999, To Jul. 2002

  大阪警察病院, 整形外科, 副医長
• From Jan. 1998, To Mar. 1999

  Osaka University, Faculty of Medicine, 助手
• From Jun. 1996, To Jan. 1998

  米国国立保健研究所（NIH), Visiting fellow
• From Apr. 1996, To May 1996

  Osaka University, Faculty of Medicine, 研究生
• From May 1989, To Mar. 1992

  Osaka University, Hospital, 研修医

ID,URL

• ORCID ID

  0000-0002-0520-3654

• J-Global ID

  200901071301101140

• External link

  http://www.cira.kyoto-u.ac.jp/j/research/tsumaki_summary.html

researchmap URL

• https://researchmap.jp/cart

Research

Research Topics, Overview of the research

• Research Topics

  Regulation of carilage and bone formation and their regeneration

• Overview of the research

  The treatment of cartilage is a challenging issue. We are investigating mechanisms regulating the formation and differentiation of cartilage. We are also going to analyze cause of cartilage diseases and to develop a method to regenerate cartilage.

Research Interests

• 整形外科
• 軟骨代謝
• Regenerative medicine

Research Areas

• Life sciences, Functional biochemistry

Papers

• Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus

  Takashi Kamatani; Hiroki Hagizawa; Seido Yarimitsu; Miho Morioka; Saeko Koyamatsu; Michihiko Sugimoto; Joe Kodama; Junko Yamane; Hiroyuki Ishiguro; Shigeyuki Shichino; Kuniya Abe; Wataru Fujibuchi; Hiromichi Fujie; Takashi Kaito; Noriyuki Tsumaki

  Biomaterials, May 2022

  
• Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice.

  Yuki Iimori; Miho Morioka; Saeko Koyamatsu; Noriyuki Tsumaki

  Tissue engineering. Part A, 16 Aug. 2021

  
• Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.

  Akihiro Yamashita; Hiroyuki Yoshitomi; Shunsuke Kihara; Junya Toguchida; Noriyuki Tsumaki

  Stem cells translational medicine, Jan. 2021

  
• Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.

  Tomonori Ozaki; Tatsuya Kawamoto; Yuki Iimori; Nobuaki Takeshita; Yukiko Yamagishi; Hiroaki Nakamura; Masazumi Kamohara; Kaori Fujita; Masayuki Tanahashi; Noriyuki Tsumaki

  Scientific reports, 01 Dec. 2020

  
• Visualization of human iPS cells-derived 3D cartilage tissue by gelatin nanospheres.

  Yuki Murata; Jun-Ichiro Jo; Hiroshi Yukawa; Noriyuki Tsumaki; Yoshinobu Baba; Yasuhiko Tabata

  Tissue engineering. Part C, Methods, 06 Mar. 2020, Peer-reviewed

  
• Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation.

  Kosai A; Horike N; Takei Y; Yamashita A; Fujita K; Kamatani T; Tsumaki N

  Biochem Biophys Res Commun., Sep. 2019, Peer-reviewed

  
• 量子ドット・磁性ナノ粒子含有ゼラチンナノ粒子を用いたヒトiPS細胞由来3次元軟骨組織の可視化

  城 潤一郎; 村田 勇樹; 湯川 博; 妻木 範行; 馬場 嘉信; 田畑 泰彦

  JSMI Report, May 2019

  
• Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia

  Kimura T; Ozaki T; Fujita K; Yamashita A; Morioka M; Ozono K; Tsumaki N

  Osteoarthritis and Cartilage, Nov. 2018, Peer-reviewed

  
• Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.

  Chen X; Yamashita A; Morioka M; Senba T; Kamatani T; Watanabe A; Kosai A; Tsumaki N

  Tissue engineering. Part A, Oct. 2018, Peer-reviewed

  
• 骨代謝と病気の新たなクロストーク:臓器連関から創薬まで 疾患特異的ヒトiPS細胞を用いた成長板軟骨モデルの確立と創薬への応用

  木村 武司; 尾崎 友則; 藤田 香里; 山下 晃弘; 森岡 美穂; 大薗 恵一; 妻木 範行

  日本骨代謝学会学術集会プログラム抄録集, Jul. 2018

  
• Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.

  Hiroki Goto; Miki Nishio; Yoko To; Tatsuya Oishi; Yosuke Miyachi; Tomohiko Maehama; Hiroshi Nishina; Haruhiko Akiyama; Tak Wah Mak; Yuma Makii; Taku Saito; Akihiro Yasoda; Noriyuki Tsumaki; Akira Suzuki

  Development (Cambridge, England), 16 Mar. 2018, Peer-reviewed

  
• A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation

  Tomohito Kobayashi; Kaori Fujita; Takashi Kamatani; Shuichi Matsuda; Noriyuki Tsumaki

  Biochemical and Biophysical Research Communications, 01 Jan. 2018, Peer-reviewed

  
• Considerations in hiPSC-derived cartilage for articular cartilage repair.

  Yamashita A; Tamamura Y; Morioka M; Karagiannis P; Shima N; Tsumaki N

  Inflammation and regeneration, 2018, Peer-reviewed

  
• A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain

  Hiroto Makino; Shoji Seki; Yasuhito Yahara; Shunichi Shiozawa; Yukihiko Aikawa; Hiraku Motomura; Makiko Nogami; Kenta Watanabe; Takeshi Sainoh; Hisakatsu Ito; Noriyuki Tsumaki; Yoshiharu Kawaguchi; Mitsuaki Yamazaki; Tomoatsu Kimura

  SCIENTIFIC REPORTS, Dec. 2017, Peer-reviewed

  
• Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages

  Takeshi Kimura; Akihiro Yamashita; Keiichi Ozono; Noriyuki Tsumaki

  TISSUE ENGINEERING PART A, Dec. 2016, Peer-reviewed

  
• Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

  Yasuhito Yahara; Hiroshi Takemori; Minoru Okada; Azuma Kosai; Akihiro Yamashita; Tomohito Kobayashi; Kaori Fujita; Yumi Itoh; Masahiro Nakamura; Hiroyuki Fuchino; Nobuo Kawahara; Naoshi Fukui; Akira Watanabe; Tomoatsu Kimura; Noriyuki Tsumaki

  NATURE COMMUNICATIONS, Mar. 2016, Peer-reviewed

  
• iPS細胞を用いた軟骨疾患に対する再生医療開発

  山下晃弘; 妻木範行

  月刊糖尿病, 2016, Invited

  
• Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.

  Itoh Yumi; Sanosaka Masato; Fuchino Hiroyuki; Yahara Yasuhito; Kumagai Ayako; Takemoto Daisaku; Kagawa Mai; Doi Junko; Ohta Miho; Tsumaki Noriyuki; Kawahara Nobuo; Takemori Hiroshi

  The Journal of biological chemistry, 17 Jul. 2015, Peer-reviewed

  
• Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes

  Yumi Itoh; Masato Sanosaka; Hiroyuki Fuchino; Yasuhito Yahara; Ayako Kumagai; Daisaku Takemoto; Mai Kagawa; Junko Doi; Miho Ohta; Noriyuki Tsumaki; Nobuo Kawahara; Hiroshi Takemori

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2015, Peer-reviewed

  
• Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

  Akihiro Yamashita; Miho Morioka; Yasuhito Yahara; Minoru Okada; Tomohito Kobayashi; Shinichi Kuriyama; Shuichi Matsuda; Noriyuki Tsumaki

  STEM CELL REPORTS, Mar. 2015, Peer-reviewed

  
• 小児疾患の新規治療開発ーiPS細胞の有用性

  妻木範行; 山下晃弘; 岡田稔

  骨と腎代謝, 2015, Invited

  
• ヒトiPS細胞からの軟骨細胞分化と硝子軟骨組織の作成

  山下晃弘; 妻木範行

  日本再生医療学会, 2015, Invited

  
• iPS cell technologies and cartilage regeneration

  Noriyuki Tsumaki; Minoru Okada; Akihiro Yamashita

  BONE, Jan. 2015, Peer-reviewed

  
• Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells

  Minoru Okada; Shiro Ikegawa; Miho Morioka; Akihiro Yamashita; Atsushi Saito; Hideaki Sawai; Jun Murotsuki; Hirofumi Ohashi; Toshio Okamoto; Gen Nishimura; Kazunori Imaizumi; Noriyuki Tsumaki

  HUMAN MOLECULAR GENETICS, Jan. 2015, Peer-reviewed

  
• Cell reprogramming for skeletal dysplasia drug repositioning

  Peter Karagiannis; Noriyuki Tsumaki

  CELL CYCLE, Dec. 2014, Peer-reviewed

  
• Cyp26b1 within the growth plate regulates bone growth in juvenile mice

  Yoshiki Minegishi; Yasuo Sakai; Yasuhito Yahara; Haruhiko Akiyama; Hideki Yoshikawa; Ko Hosokawa; Noriyuki Tsumaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2014, Peer-reviewed

  
• Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

  Akihiro Yamashita; Miho Morioka; Hiromi Kishi; Takeshi Kimura; Yasuhito Yahara; Minoru Okada; Kaori Fujita; Hideaki Sawai; Shiro Ikegawa; Noriyuki Tsumaki

  NATURE, Sep. 2014, Peer-reviewed

  
• Cartilage intermediate layer protein promotes lumbar disc degeneration

  Shoji Seki; Noriyuki Tsumaki; Hiraku Motomura; Makiko Nogami; Yoshiharu Kawaguchi; Takeshi Hori; Kayo Suzuki; Yasuhito Yahara; Mami Higashimoto; Takeshi Oya; Shiro Ikegawa; Tomoatsu Kimura

  Biochemical and Biophysical Research Communications, 18 Apr. 2014, Peer-reviewed

  
• Cartilage intermediate layer protein promotes lumbar disc degeneration

  Shoji Seki; Noriyuki Tsumaki; Hiraku Motomura; Makiko Nogami; Yoshiharu Kawaguchi; Takeshi Hori; Kayo Suzuki; Yasuhito Yahara; Mami Higashimoto; Takeshi Oya; Shiro Ikegawa; Tomoatsu Kimura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2014, Peer-reviewed

  
• Sox9 Reprogrammed Dermal Fibroblasts Undergo Hypertrophic Differentiation In Vitro and Trigger Endochondral Ossification In Vivo

  Wai Long Tam; F. O. Dorien; Kunihiko Hiramatsu; Noriyuki Tsumaki; Frank P. Luyten; Scott J. Roberts

  CELLULAR REPROGRAMMING, Feb. 2014, Peer-reviewed

  
• Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters

  Y. Minegishi; K. Hosokawa; N. Tsumaki

  OSTEOARTHRITIS AND CARTILAGE, Dec. 2013, Peer-reviewed

  
• Direct Induction of Chondrogenic Cells from Human Dermal Fibroblast Culture by Defined Factors

  Hidetatsu Outani; Minoru Okada; Akihiro Yamashita; Kanako Nakagawa; Hideki Yoshikawa; Noriyuki Tsumaki

  PLoS ONE, 16 Oct. 2013, Peer-reviewed

  
• iPS細胞を使うー軟骨の研究へ

  妻木範行; 岡田稔; 山下晃弘

  整形外科, 2013, Invited

  
• iPS細胞由来軟骨細胞を用いた再生治療開発

  山下晃弘; 妻木範行

  Phama Medica, 2013, Invited

  
• Stem cell aging and the implications for stem cell-based therapies for aging-related diseases and aged tissues

  Fujita K; Tsumaki N

  Clin Calcium., Jan. 2013, Invited

  
• Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification

  Riko Nishimura; Makoto Wakabayashi; Kenji Hata; Takuma Matsubara; Shiho Honma; Satoshi Wakisaka; Hiroshi Kiyonari; Go Shioi; Akira Yamaguchi; Noriyuki Tsumaki; Haruhiko Akiyama; Toshiyuki Yoneda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2012, Peer-reviewed

  
• An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

  Kohji Miura; Noriyuki Namba; Makoto Fujiwara; Yasuhisa Ohata; Hidekazu Ishida; Taichi Kitaoka; Takuo Kubota; Haruhiko Hirai; Chikahisa Higuchi; Noriyuki Tsumaki; Hideki Yoshikawa; Norio Sakai; Toshimi Michigami; Keiichi Ozono

  PLOS ONE, Aug. 2012, Peer-reviewed

  
• Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice

  Tatsuya Uebi; Yumi Itoh; Osamu Hatano; Ayako Kumagai; Masato Sanosaka; Tsutomu Sasaki; Satoru Sasagawa; Junko Doi; Keita Tatsumi; Kuniko Mitamura; Eiichi Morii; Katsuyuki Aozasa; Tomohiro Kawamura; Meinoshin Okumura; Jun Nakae; Hajime Takikawa; Toshio Fukusato; Minako Koura; Mayumi Nish; Anders Hamsten; Angela Silveira; Alejandro M. Bertorello; Kazuo Kitagawa; Yasuo Nagaoka; Hidehisa Kawahara; Takeshi Tomonaga; Tetsuji Naka; Shigeo Ikegawa; Noriyuki Tsumaki; Junichiro Matsuda; Hiroshi Takemori

  PLOS ONE, May 2012, Peer-reviewed

  
• SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

  Satoru Sasagawa; Hiroshi Takemori; Tatsuya Uebi; Daisuke Ikegami; Kunihiko Hiramatsu; Shiro Ikegawa; Hideki Yoshikawa; Noriyuki Tsumaki

  Development, Mar. 2012, Peer-reviewed

  
• SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

  Satoru Sasagawa; Hiroshi Takemori; Tatsuya Uebi; Daisuke Ikegami; Kunihiko Hiramatsu; Shiro Ikegawa; Hideki Yoshikawa; Noriyuki Tsumaki

  DEVELOPMENT, Mar. 2012, Peer-reviewed

  
• Conditional Deletion of Bmpr1a in Differentiated Osteoclasts Increases Osteoblastic Bone Formation, Increasing Volume of Remodeling Bone in Mice

  Mina Okamoto; Junko Murai; Yuuki Imai; Daisuke Ikegami; Nobuhiro Kamiya; Shigeaki Kato; Yuji Mishina; Hideki Yoshikawa; Noriyuki Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Oct. 2011, Peer-reviewed

  
• Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state

  Hidetatsu Outani; Minoru Okada; Kunihiko Hiramatsu; Hideki Yoshikawa; Noriyuki Tsumaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2011, Peer-reviewed

  
• ナトリウム利尿ペプチド受容体Bの機能獲得型変異はヒトおよびマウスにおいて成長促進と低骨密度をもたらす

  三浦 弘司; 難波 範行; 藤原 誠; 北岡 太一; 大幡 泰久; 平井 治彦; 大薗 恵一; 樋口 周久; 妻木 範行; 吉川 秀樹; 道上 敏美

  日本骨代謝学会学術集会プログラム抄録集, Jul. 2011, Peer-reviewed

  
• Expression of dominant negative TGF-beta receptors inhibits cartilage formation in conditional transgenic mice

  Kunihiko Hiramatsu; Takao Iwai; Hideki Yoshikawa; Noriyuki Tsumaki

  JOURNAL OF BONE AND MINERAL METABOLISM, Jul. 2011, Peer-reviewed

  
• Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

  Daisuke Ikegami; Haruhiko Akiyama; Akira Suzuki; Takashi Nakamura; Toru Nakano; Hideki Yoshikawa; Noriyuki Tsumaki

  DEVELOPMENT, Apr. 2011, Peer-reviewed

  
• Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

  Yukio Nakamura; Koji Yamamoto; Xinjun He; Bungo Otsuki; Youngwoo Kim; Hiroki Murao; Tsunemitsu Soeda; Noriyuki Tsumaki; Jian Min Deng; Zhaoping Zhang; Richard R. Behringer; Benoit de Crombrugghe; John H. Postlethwait; Matthew L. Warman; Takashi Nakamura; Haruhiko Akiyama

  NATURE COMMUNICATIONS, Mar. 2011, Peer-reviewed

  
• Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage

  D. Ikegami; T. Iwai; S. Ryo; N. Gu; T. Sugiyama; I. Oh; H. Yoshikawa; N. Tsumaki

  OSTEOARTHRITIS AND CARTILAGE, Feb. 2011, Peer-reviewed

  
• Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors

  Kunihiko Hiramatsu; Satoru Sasagawa; Hidetatsu Outani; Kanako Nakagawa; Hideki Yoshikawa; Noriyuki Tsumaki

  JOURNAL OF CLINICAL INVESTIGATION, Feb. 2011, Peer-reviewed

  
• Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development

  Dai Suzuki; Atsushi Yamada; Takanori Amano; Rika Yasuhara; Ayako Kimura; Mizuho Sakahara; Noriyuki Tsumaki; Shu Takeda; Masaru Tamura; Masanori Nakamura; Naoyuki Wada; Tsutomu Nohno; Toshihiko Shiroishi; Atsu Aiba; Ryutaro Kamijo

  DEVELOPMENTAL BIOLOGY, Nov. 2009, Peer-reviewed

  
• Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene. (vol 275, pg 12712, 2000)

  Ying Liu; Haochuan Li; Kazuhiro Tanaka; Noriyuki Tsumaki; Yoshihiko Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2009, Peer-reviewed

  
• Generation of Rac1 conditional mutant mice by Cre/loxP system

  Dai Suzuki; Atsushi Yamada; Takanori Amano; Ayako Kimura; Rika Yasuhara; Mizuho Sakahara; Masaru Tamura; Noriyuki Tsumaki; Shu Takeda; Masanori Nakamura; Toshihiko Shiroishi; Atsu Aiba; Ryutaro Kamijo

  TRANSMITTERS AND MODULATORS IN HEALTH AND DISEASE, 2009, Peer-reviewed

  
• Bone biology: Development and regeneration mechanisms in physiological and pathological conditions

  Hideki Yoshikawa; Noriyuki Tsumaki; Akira Myoui

  Strategies in Regenerative Medicine: Integrating Biology with Materials Design, 2009, Peer-reviewed

  
• Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2

  Junko Murai; Daisuke Ikegami; Mina Okamoto; Hideki Yoshikawa; Noriyuki Tsumaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2008, Peer-reviewed

  
• Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways

  Takao Iwai; Junko Murai; Hideki Yoshikawa; Noriyuki Tsumaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2008, Peer-reviewed

  
• Characteristics of fracture and related factors in patients with rheumatoid arthritis

  Akihide Nampei; Jun Hashimoto; Junichiro Koyanagi; Takeshi Ono; Hideo Hashimoto; Noriyuki Tsumaki; Tetsuya Tomita; Kazuomi Sugamoto; Norihiro Nishimoto; Takahiro Ochi; Hideki Yoshikawa

  MODERN RHEUMATOLOGY, Apr. 2008, Peer-reviewed

  
• Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic

  Iwai, Takao; Harada, Yoshifumi; Imura, Koichi; Iwabuchi, Sadahiro; Murai, Junko; Hiramatsu, Kunihiko; Myoui, Akira; Yoshikawa, Hideki; Tsumaki, Noriyuki

  JOURNAL OF BONE AND MINERAL METABOLISM, Nov. 2007, Peer-reviewed

  
• Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts

  Tadashi Sugiki; Taro Uyama; Masashi Toyoda; Hideo Morioka; Shoen Kume; Kenji Miyado; Kenji Matsumoto; Hirohisa Saito; Noriyuki Tsumaki; Yoriko Takahashi; Yoshiaki Toyama; Akihiro Umezawa

  JOURNAL OF CELLULAR BIOCHEMISTRY, Apr. 2007, Peer-reviewed

  
• Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification

  Makoto Hirao; Noriyuki Tamai; Noriyuki Tsumaki; Hideki Yoshikawa; Akira Myoui

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2006, Peer-reviewed

  
• Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development

  M Okamoto; J Murai; H Yoshikawa; N Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Jul. 2006, Peer-reviewed

  
• [Bone morphogenetic proteins and their related molecules in the skeletal tissue].

  Tsumaki N; Yoshikawa H

  Clinical calcium, May 2006, Peer-reviewed

  
• [Roles of BMPs during endochondral bone formation].

  Iwai T; Tsumaki N; Yoshikawa H

  Nihon rinsho. Japanese journal of clinical medicine, Oct. 2005, Peer-reviewed

  
• The role of bone morphogenetic proteins in endochondral bone formation

  N Tsumaki; H Yoshikawa

  CYTOKINE & GROWTH FACTOR REVIEWS, Jun. 2005, Peer-reviewed

  
• Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis

  N Tsumaki; M Kakiuchi; J Sasaki; T Ochi; H Yoshikawa

  JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, Nov. 2004, Peer-reviewed

  
• Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow

  R Katayama; S Wakitani; N Tsumaki; Y Morita; Matsushita, I; R Gejo; T Kimura

  RHEUMATOLOGY, Aug. 2004, Peer-reviewed

  
• [Role of BMPs and Smads during endochondral bone formation].

  Tsumaki N; Horiki M; Murai J; Yoshikawa H

  Clinical calcium, Jul. 2004, Peer-reviewed

  
• Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

  M Horiki; T Imamura; M Okamoto; M Hayashi; J Murai; A Myoui; T Ochi; K Miyazono; H Yoshikawa; N Tsumaki

  JOURNAL OF CELL BIOLOGY, May 2004, Peer-reviewed

  
• COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG

  Y Matsui; HA Chansky; F Barahmand-Pour; A Zielinska-Kwiatkowska; N Tsumaki; A Myoui; H Yoshikawa; L Yang; DR Eyre

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2003, Peer-reviewed

  
• Cartilage-specific overexpression of C-propeptide of type II collagen affected matrix mineralization in transgenic mice

  Y. Matsui; K. Nakata; E. Adachi; N. Tsumaki; T. Kimura; N. Yasui; E. Kataoka; Y. Fujita; H. Tsuboi; H. Yoshikawa

  Journal of Musculoskeletal Research, 2003, Peer-reviewed

  
• Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells

  Y Matsui; N Araki; H Tsuboi; N Tsumaki; K Nakata; H Kawabata; DR Eyre; H Yoshikawa

  ANTICANCER RESEARCH, Nov. 2002, Peer-reviewed

  
• Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis

  N Tsumaki; T Nakase; T Miyaji; M Kakiuchi; T Kimura; T Ochi; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, May 2002, Peer-reviewed

  
• Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff

  Takanobu Nakase; Kazuomi Sugamoto; Takashi Miyamoto; Noriyuki Tsumaki; Frank P. Luyten; Hiroaki Inui; Akira Myoui; Tetsuya Tomita; Hideki Yoshikawa

  Clinical Orthopaedics and Related Research, 2002, Peer-reviewed

  
• Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum

  T Nakase; K Ariga; K Yonenobu; N Tsumaki; FP Luyten; Y Mukai; Sato, I; H Yoshikawa

  EUROPEAN SPINE JOURNAL, Aug. 2001, Peer-reviewed

  
• Alternative splicing of fibronectin transcripts in osteochondrogenic tumors

  Y Matsui; K Nakata; N Araki; K Ozono; Y Fujita; N Tsumaki; H Kawabata; N Yasui; K Sekiguchi; H Yoshikawa

  ANTICANCER RESEARCH, Mar. 2001, Peer-reviewed

  
• Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene

  Y Liu; HC Li; K Tanaka; N Tsumaki; Y Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2000, Peer-reviewed

  
• Enhancer analysis of the alpha 1(II) and alpha 2(XI) collagen genes in transfected chondrocytes and transgenic mice.

  N. Tsumaki; Y. Liu; Y. Yamada; P. Krebsbach

  Methods in molecular biology (Clifton, N.J.), 2000, Peer-reviewed

  
• A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia

  Y Matsui; N Yasui; H Kawabata; K Ozono; K Nakata; T Mizushima; N Tsumaki; E Kataoka; Y Fujita; T Ochi

  JOURNAL OF HUMAN GENETICS, 2000, Peer-reviewed

  
• Role of CDMP-1 in skeletal morphogenesis: Promotion of mesenchymal cell recruitment and chondrocyte differentiation

  N Tsumaki; K Tanaka; E Arikawa-Hirasawa; T Nakase; T Kimura; JT Thomas; T Ochi; FP Luyten; Y Yamada

  JOURNAL OF CELL BIOLOGY, Jan. 1999, Peer-reviewed

  
• Genotype phenotype correlation in achondroplasia and hypochondroplasia

  Y Matsui; N Yasui; T Kimura; N Tsumaki; H Kawabata; T Ochi

  JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, Nov. 1998, Peer-reviewed

  
• Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha 2(XI) collagen promoter

  N Tsumaki; T Kimura; K Tanaka; JH Kimura; T Ochi; Y Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1998, Peer-reviewed

  
• Differential in situ expression of alpha 2(XI) collagen mRNA isoforms in the developing mouse

  M Sugimoto; T Kimura; N Tsumaki; Y Matsui; K Nakata; H Kawahata; N Yasui; Y Kitamura; S Nomura; T Ochi

  CELL AND TISSUE RESEARCH, May 1998, Peer-reviewed

  
• Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors

  Y Matsui; T Kimura; N Tsumaki; K Nakata; N Yasui; N Araki; N Hashimoto; A Uchida; T Ochi

  CANCER LETTERS, Feb. 1998, Peer-reviewed

  
• A recurrent 1992delCT mutation of the type X collagen gene in a Japanese patient with Schmid metaphyseal chondrodysplasia

  Y Matsui; T Kimura; N Tsumaki; N Yasui; T Ochi

  JAPANESE JOURNAL OF HUMAN GENETICS, Sep. 1996, Peer-reviewed

  
• Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage

  N Tsumaki; T Kimura; Y Matsui; K Nakata; T Ochi

  JOURNAL OF CELL BIOLOGY, Sep. 1996, Peer-reviewed

  
• Cervical spondylotic radiculopathy involving two adjacent nerve roots - Anterior decompression through a single level intervertebral approach

  M Iwasaki; K Okada; N Tsumaki; H Obata; N Shirasaki; S Oka

  INTERNATIONAL ORTHOPAEDICS, Jun. 1996, Peer-reviewed

  
• Progressive degeneration of articular cartilage and intervertebral discs - An experimental study in transgenic mice bearing a type IX collagen mutation

  T Kimura; K Nakata; N Tsumaki; S Miyamoto; Y Matsui; S Ebara; T Ochi

  INTERNATIONAL ORTHOPAEDICS, Jun. 1996, Peer-reviewed

  
• Separable regulatory elements from pro-alpha 2(XI) collagen gene drive distinct patterns of cartilage-specific expression in transgenic mice

  N Tsumaki; M Sugimoto; K Nakata; Y Matsui; T Ochi; T Kimura

  MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CARTILAGE, 1996, Peer-reviewed

  
• DIFFERENTIAL EXPRESSION OF AN ACIDIC DOMAIN IN THE AMINO-TERMINAL PROPEPTIDE OF MOUSE PRO-ALPHA-2(XI) COLLAGEN BY COMPLEX ALTERNATIVE SPLICING

  N TSUMAKI; T KIMURA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1995, Peer-reviewed

  
• ALTERED CHONDROCYTE GENE-EXPRESSION IN ARTICULAR-CARTILAGE MATRIX COMPONENTS AND SUSCEPTIBILITY TO CARTILAGE DESTRUCTION

  T KIMURA; K NAKATA; N TSUMAKI; K ONO

  CELL MECHANICS AND CELLULAR ENGINEERING, 1994, Peer-reviewed

  

Misc.

• Effect of low-intensity pulsed ultrasound on maturation of callus in opening-wedge high tibial osteotomy by hemicallotasis

  TSUMAKI Noriyuki; KAKIUCHI Masaaki; SASAKI Jiro; OCHI Takahiro; YOSHIKAWA Hideki

  日本創外固定・骨延長学会雑誌 = The journal of the Japanese Association of External Fixation and Limb Lengthening, 20 May 2005

  
• A common FGFR3 mutation functions as a diagnostic marker for achondroplasia-group disorders in the Japanese population

  MATSUI YOSHITO; KIMURA TOMOATSU; TSUMAKI NORIYUKI; NAKAHARA HARUHIKO; ARAKI NOBUHITO; YASUI NATSUO; OCHI TAKAHIRO

  J. Orthop. Sci., 01 Mar. 1996

  
• 軟骨の形成・分化に対するBMPシグナルの作用

  妻木 範行; 中瀬 尚長; 冨田 哲也; 吉川 秀樹; 垣内 雅明; 木村 友厚; YAMADA Y.; 越智 隆弘

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Aug. 1999

  
• 軟骨組織特異的遺伝子発現システムを用いた関節軟骨への in vivo 遺伝子導入

  片山 理恵; 冨田 哲也; 妻木 範行; 越智 隆弘; 松野 博明; 遊道 和雄; 中沢 不二雄; 木村 友厚

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Aug. 1999

  
• 軟骨の発生・分化に対する Cartilage-Derived Morphogenetic Protein-1 (CDMP-1) の作用

  妻木 範行; TANAKA K.; ARIKAWA HIRASAWA E.; THOMAS J. T.; 越智 隆弘; LUYTEN F. P.; 木村 友厚; YAMADA Y.

  日本骨代謝学会雑誌 = Japanese journal of bone metabolism, 07 Jul. 1998

  
• マウスXI型コラーゲンα2鎖遺伝子の軟骨特異的発現にかかわる転写制御領域の解析

  妻木 範行; 木村 友厚; 松井 好人; 杉本 瑞生; 中田 研; 越智 隆弘

  日本骨代謝学会雑誌 = Japanese journal of bone metabolism, 01 Jun. 1996

  
• Role of CDMP-1 in Skeletal Morphogenesis : Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation

  TSUMAKI N.; THOMAS J. T.; LUYTEN F. P.; YAMADA Y.

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Aug. 1998

  
• Paediatric and Adolescent Throwing Injury : The Actual Conditions and Its Prevention

  MASATOMI T.

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Feb. 1995

  
• Identification of the regulatory sequences responsible for cartilage-specific expression of the Col11a2 gene and their application : a role of BMP signals in the skeletal development

  Tsumaki N.; Kimura T.; Yamada Y.; Ochi T.

  Connective tissue, Jun. 1999

  
• Targeted expression of CDMP-1 in mouse cartilage expands primordial cartilage and enhances chondrocyte differentiation

  Tsumaki N.; Tanaka K.; Akikawa-Hirasawa E.; Thomas J.T.; Ochi T.; Luyten F.P.; Kimura T.; Yamada Y.

  Connective tissue, 05 Jun. 1998

  
• BMP signals are required for cartilage formation.

  Tsumaki N.; Nakase T.; Miyaji E. T.; Kakiuchi M.; Ochi T.; Yamada Yoshihiko; Kimura T.; Yoshikawa H.

  Connective tissue, Jun. 2001

  
• 軟骨変性と遺伝子の発現 -軟骨細胞signaling pathway における意味づけ-

  妻木 範行; 垣内 雅明; 吉川 秀樹; 木村 友厚; 越智 隆弘

  リウマチ, 26 Apr. 2000

  
• 軟骨特異的転写制御メカニズムの解明とその応用

  妻木 範行; 木村 友厚; YAMADA Yoshihiko; 越智 隆弘

  リウマチ, 30 Apr. 1999

  
• Role of BMP4 during Chondrocyte Differentiation

  TSUMAKI N.

  日本整形外科學會雜誌, 25 Aug. 2000

  
• Transcriptional Regulation of Cartilage-specific Collagen Gene, Col11a2

  TSUMAKI N.; YAMADA Yoshihiko

  日本整形外科學會雜誌, 25 Feb. 2000

  
• Collagen Genes and Skeletal Disorders

  KIMURA Tomoatsu; TSUMAKI Noriyuki; MATSUI Yoshito

  リウマチ, Jun. 1995

  
• 膝内反変形を伴う膝関節内側軟骨障害に対し自家骨軟骨移植術と高位脛骨骨切り術同時施行例の術後成績

  中田 研; 史野 根生; 桑野 吉浩; 福岡 慎一; 田川 泰弘; 妻木 範行; 小畠 秀人; 多田 浩一

  日本整形外科学会雑誌, Mar. 2003

  
• 軟骨性腫瘍におけるフィブロネクチンmRNAの選択的スプライシング

  松井 好人; 中田 研; 安井 夏生; 荒木 信人; 大薗 恵一; 妻木 範行; 藤田 良; 栗山 幸治; 川端 秀彦; 越智 隆弘

  日本整形外科学会雑誌, 25 Aug. 2000

  
• II型コラーゲンCプロペプチドが軟骨分化と軟骨基質の石灰化に及ぼす作用 過剰発現トランスジェニックマウスを用いた解析

  松井 好人; 中田 研; 安達 栄治郎; 木村 友厚; 妻木 範行; 安井 夏生; 片岡 英一郎; 藤田 良; 越智 隆弘

  日本整形外科学会雑誌, Aug. 1999

  
• 【変形性関節症の基礎と臨床】 OAの動物モデル

  木村 友厚; 松野 博明; 遊道 和雄; 中田 研; 妻木 範行

  リウマチ科, Jul. 1999

  
• II型コラーゲンCプロペプチド過剰発現マウスにおける内軟骨性骨形成の変化

  松井 好人; 中田 研; 木村 友厚; 妻木 範行; 山田 吉彦; 安井 夏生; 片岡 英一郎; 越智 隆弘

  日本整形外科学会雑誌, 25 Aug. 1998

  
• マウスXI型コラーゲンα2鎖遺伝子転写制御領域の解析 トランスジェニックマウスを用いて

  妻木 範行; 木村 友厚; 中田 研

  日本整形外科学会雑誌, 25 Aug. 1995

  
• 発生工学を用いた病態動物モデル 軟骨異常トランスジェニックマウスの作製と解析

  中田 研; 妻木 範行; 木村 友厚

  BIO medica, Dec. 1993

  
• II型コラーゲン遺伝子の軟骨特異的エンハンサーに結合するタンパク質(CSEBP-2)の遺伝子発現とゲノム構造の解析

  片岡 英一郎; 丹羽 仁史; 中田 研; 松井 好人; 木村 友厚; 妻木 範行; 山田 吉彦; 安井 夏生; 宮崎 純一; 越智 隆弘

  日本整形外科学会雑誌, 25 Aug. 1999

  
• 疾患特異的ヒトiPS細胞を用いた内軟骨性骨化モデル

  木村武司; 木村武司; 安田紀恵; 窪田拓生; 三善陽子; 山下晃弘; 妻木範行; 大薗恵一

  日本小児内分泌学会学術集会プログラム・抄録集, 2017

  
• ヒトiPS細胞由来軟骨細胞の免疫原性の解析

  木村武司; 木村武司; 森岡美穂; 山下晃弘; 大薗恵一; 妻木範行

  日本軟骨代謝学会プログラム・抄録集, 2016

  
• 疾患特異的iPS細胞モデルを用いた軟骨形成に対するIGF1の効果の検討

  木村武司; 木村武司; 森岡美穂; 山下晃弘; 妻木範行; 大薗恵一

  日本整形外科学会雑誌, 2015

  
• 連通気孔を有する3D-CAD人工骨を用いた高位脛骨骨切術の短期成績

  妻木 範行; 海渡 貴司; 岩井 貴男; 村瀬 剛; 名井 陽; 吉川 秀樹

  日本整形外科学会雑誌, Mar. 2006

  
• The effect of IGF-1 on chondrogcnic differentiation model with disease-specific human induced pluripotent stem cells

  木村 武司; 妻木 範行; 大薗 恵一

  ホルモンと臨床, Jan. 2015

  
• 11型コラ-ゲンの構造と機能 (特集 マトリックス生物学の最前線)

  木村 友厚; 妻木 範行; 越智 隆弘

  生体の科学, Aug. 1997

  
• A Therapeutic Target of Intervertebral Disc Disease and Regeneration Based on Suppressing Intervertebral Disc Degeneration

  関 庄二; 牧野 紘士; 箭原 康人; 元村 拓; 野上 真紀子; 渡邊 健太; 淺沼 由美子; 川口 善治; Masuda Koichi; 妻木 範行; 木村 友厚

  Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, Jun. 2017

  
• iPS細胞および分子標的によるOA治療戦略 (特集 OAの最新治療 : 関節再生を目指して)

  妻木 範行

  分子リウマチ治療, May 2017

  
• ROLE OF SIK3 IN PATHOLOGY OF OSTEOARTHRITIS IN MICE

  N. Tsumaki

  OSTEOARTHRITIS AND CARTILAGE, Apr. 2017

  
• Application of iPS cell technologies to regeneration of cartilage damage

  妻木 範行

  Osaka Academy of Oral Implantology, 2017

  
• ESTABLISHMENT OF A HUMAN GROWTH PLATE MODEL WITH IPS CELL-DERIVED CARTILAGE

  Takeshi Kimura; Akihiro Yamashita; Keiichi Ozono; Noriyuki Tsumaki

  HORMONE RESEARCH IN PAEDIATRICS, 2017

  
• Use of Cell iPS Cell Technologies in Cartilage Regeneration and Disease Modelling of Skeletal Dysplasia

  妻木 範行

  最新医学, Aug. 2016

  
• Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 (vol 7, 10959, 2016)

  Yasuhito Yahara; Hiroshi Takemori; Minoru Okada; Azuma Kosai; Akihiro Yamashita; Tomohito Kobayashi; Kaori Fujita; Yumi Itoh; Masahiro Nakamura; Hiroyuki Fuchino; Nobuo Kawahara; Naoshi Fukui; Akira Watanabe; Tomoatsu Kimura; Noriyuki Tsumaki

  NATURE COMMUNICATIONS, Jun. 2016

  
• スタチンによるFGFR3軟骨形成異常症の病態回復

  山下晃弘; 森岡美帆; 岸宏美; 木村武司; 箭原康人; 岡田稔; 藤田香里; 澤井英明; 池川志郎; 妻木範行

  日本軟骨代謝学会プログラム・抄録集, 2016

  
• Chondrogenic differentiation of human iPS cells and production of hyaline cartilaginous tissue

  山下 晃弘; 妻木 範行

  再生医療 : 日本再生医療学会雑誌, Nov. 2015

  
• Drug screening using iPS cell model and direct reprogramming technologies

  妻木 範行

  整形・災害外科, Mar. 2015

  
• DERIVATION OF TRANSPLANTABLE CARTILAGE FROM HUMAN INDUCED PLURIPOTENT STEM CELLS

  A. Yamashita; M. Morioka; Y. Yahara; M. Okada; N. Tsumaki

  OSTEOARTHRITIS AND CARTILAGE, Apr. 2014

  
• Cartilage regeneration by chondrogenic cells generated by cell reprogramming technologies

  妻木 範行

  整形・災害外科, Apr. 2013

  
• Regulation of chondrocyte differentiation and cartilage regeneration

  妻木 範行

  細胞, Jan. 2013

  
• 致死性骨異形成症の診断と予後に関する研究 症例の収集と診断の支援システム構築

  室月淳; 澤井英明; 山田崇弘; 堤誠司; 佐藤秀平; 林聡; 篠塚憲男; 高橋雄一郎; 佐世正勝; 鬼頭浩史; 沼部博直; 宮崎治; 緒方勤; 池川志郎; 妻木範行; 芳賀信彦; 西村玄

  致死性骨異形成症の診断と予後に関する研究 平成24年度 総括・分担研究報告書, 2013

  
• 細胞リプログラミング技術を用いたII型コラーゲン病疾患モデルの解析

  岡田稔; 池川志郎; 今泉和則; 澤井英明; 室月淳; 大橋博文; 妻木範行

  日本軟骨代謝学会プログラム・抄録集, 2013

  
• 致死性骨異形成症の診断と予後に関する研究 致死性骨異形成症のiPS細胞作成に関する研究

  妻木範行; 澤井英明; 室月淳; 池川志郎

  致死性骨異形成症の診断と予後に関する研究 平成24年度 総括・分担研究報告書, 2013

  
• ナトリウム利尿ペプチド受容体B(NPR-B)変異に起因する軟骨の表現型の解析

  三浦 弘司; 難波 範行; 藤原 誠; 大幡 泰久; 北岡 太一; 窪田 拓生; 大薗 恵一; 樋口 周久; 吉川 秀樹; 妻木 範行; 道上 敏美

  日本内分泌学会雑誌, Apr. 2012

  
• 致死性骨異形成症の診断と予後に関する研究 症例の収集と診断の支援システム構築

  室月淳; 澤井英明; 山田崇弘; 堤誠司; 佐藤秀平; 林聡; 篠塚憲男; 高橋雄一郎; 佐世正勝; 鬼頭浩史; 沼部博直; 宮崎治; 緒方勤; 池川志郎; 妻木範行; 西村玄

  致死性骨異形成症の診断と予後に関する研究 平成23年度 総括・分担研究報告書, 2012

  
• Directed induction of chondrogenic cells from mouse dermal fibroblast culture

  Noriyuki Tsumaki

  ARTHRITIS RESEARCH & THERAPY, 2012

  
• A GAIN-OF-FUNCTION TYPE MUTATION OF THE NATRIURETIC PEPTIDE RECEPTOR B CAUSES ACCELERATION OF SKELETAL GROWTH AND OSTEOPOROTIC CHANGE IN HUMANS AND MICE

  K. Miura; N. Namba; M. Fujiwara; T. Kitaoka; Y. Ohata; H. Hirai; C. Higuchi; N. Tsumaki; H. Yoshikawa; T. Michigami; K. Ozono

  OSTEOPOROSIS INTERNATIONAL, Sep. 2011

  
• CILP(cartilage intermediate layer protein)トランスジェニックマウスの椎間板変性促進効果

  関庄二; 妻木範行; 松井好人; 川口善治; 阿部由美子; 鈴木賀代; 岩井昭子; 佐野明美; 尾矢剛志; 池川志郎; 木村友厚

  日本整形外科学会雑誌, 2010

  
• 関節リウマチ患者骨髄中の原因病巣を探り続けて

  越智 隆弘; 吉川 秀樹; 橋本 淳; 中田 研; 妻木 範行; 冨田 哲也; 島岡 康則; 蛯名 耕介; 武 靖浩; 鈴木 隆二; 澤井 高志

  日本整形外科学会雑誌, Aug. 2009

  
• Essential role of small GTPase Rac1 during limb development

  D. Suzuki; A. Yamada; T. Amano; A. Kimura; R. Yasuhara; M. Sakahara; M. Tamura; N. Tsumaki; S. Takeda; M. Nakamura; T. Shiroishi; A. Aiba; R. Kamijo

  BONE, May 2009

  
• Rac1はプログラム細胞死関連遺伝子の発現調節を介して肢芽指間域におけるアポトーシスを制御する

  鈴木 大; 山田 篤; 天野 孝紀; 木村 文子; 安原 理佳; 妻木 範行; 竹田 秀; 田村 勝; 中村 雅典; 城石 俊彦; 饗場 篤; 上條 竜太郎

  口腔組織培養学会誌, Feb. 2009

  
• 低分子量Gタンパク質Rac1は四肢形成に必須である

  鈴木 大; 山田 篤; 木村 文子; 安原 理佳; 妻木 範行; 竹田 秀; 松本 貴志; 馬場 一美; 中村 雅典; 饗場 篤; 上條 竜太郎

  日本骨代謝学会学術集会プログラム抄録集, Oct. 2008

  
• 低分子量Gタンパク質Rac1は四肢形成に必須である

  鈴木 大; 山田 篤; 安原 理佳; 木村 文子; 妻木 範行; 竹田 秀; 中村 雅典; 饗場 篤; 上條 竜太郎

  補体シンポジウム講演集, Jul. 2008

  
• Inhibitory Smad6 and Smad7 differently regulate cartilage formation

  T. Iwai; J. Murai; H. Yoshikawa; N. Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2007

  
• Analysis of the function of the CTCF-binding site between the Rxrb and the Col11a2 genes

  J. Murai; M. Okamoto; H. Yoshikawa; N. Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2007

  
• Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts

  Tadashi Sugiki; Taro Uyama; Masashi Toyoda; Hideo Morioka; Shoen Kume; Kenji Miyado; Kenji Matsumoto; Hirohisa Saito; Noriyuki Tsumaki; Yoriko Takahashi; Yoshiaki Toyama; Akihiro Umezawa

  JOURNAL OF CELLULAR BIOCHEMISTRY, Apr. 2007

  
• 最新原著レビュー 低出力超音波パルス照射は片側仮骨延長法を用いた高位脛骨骨切り術における延長仮骨治癒を促進する

  妻木 範行

  整形外科, Oct. 2006

  
• Regulation of the col11a2 expression through the histone modification.

  J. Murai; H. Yoshikawa; N. Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2006

  
• Role of Smad7 during endochondral bone formation.

  T. Iwai; J. Murai; H. Yoshikawa; N. Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2006

  
• Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development

  M Okamoto; J Murai; H Yoshikawa; N Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Jul. 2006

  
• Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene (vol 275, pg 12712, 2000)

  Y Liu; HC Li; K Tanaka; N Tsumaki; Y Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2006

  
• CTデータに基づく3D-CADモデルを利用した手術シミュレーションおよびハイドロキシアパタイトインプラントの術前モデリング

  海渡 貴司; 名井 陽; 村瀬 剛; 妻木 範行; 冨田 哲也; 吉川 秀樹

  Orthopaedic Ceramic Implants, Dec. 2005

  
• CTデータに基づく3D-CADモデルを利用したハイドロキシアパタイトインプラントの術前モデリング

  村瀬 剛; 海渡 貴司; 名井 陽; 玉井 宣行; 妻木 範行; 冨田 哲也; 森友 寿夫; 岡 久仁洋; 吉川 秀樹

  日本バイオマテリアル学会大会予稿集, Nov. 2005

  
• BMP signaling in bone stimulates osteoclastic bone resorption and remodeling during endochondral bone formation and fracture repair.

  M Okamoto; J Murai; H Yoshikawa; N Tsumaki

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2005

  
• Hypoxia promotes cartilage matrix synthesis via p38 MAPKinase and suppresses terminal differentiation via HDAC4

  M Hirao; N Tamai; A Myoui; N Tsumaki; N Araki; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2005

  
• Low-intensity pulsed ultrasound and new bone formation within interconnected porous calcium hydroxyapatite ceramics.

  T Iwai; N Tsumaki; J Murai; A Myoui; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2005

  
• Role of BMP signals in endochondral ossification and fracture repair; Activation of osteoclastic resorption and remodeling of bone

  M Okamoto; J Murai; H Yoshikawa; N Tsumaki

  BONE, Jun. 2005

  
• Overexpression of BMP4 in bone increased osteoclast number and caused osteopenia

  J Murai; M Okamoto; H Yoshikawa; N Tsumaki

  BONE, Jun. 2005

  
• Bone morphogenetic protein signaling in chondrocyte proliferation and hypertrophy during endochondral bone formation

  T Iwai; M Horiki; J Murai; H Yoshikawa; N Tsumaki

  BONE, Jun. 2005

  
• CTデータに基づく3D-CADを利用したハイドロキシアパタイトインプラントの術前モデリング

  村瀬 剛; 海渡 貴司; 名井 陽; 玉井 宣行; 妻木 範行; 冨田 哲也; 森友 寿夫; 岡 久仁洋; 上田 孝文; 菅本 一臣; 吉川 秀樹

  日本整形外科学会雑誌, Mar. 2005

  
• The role of bone morphogenetic proteins in endochondral bone formation

  Cytokine Growth Factor Rev, 2005

  
• Tsumaki, N. and Yoshikawa, H.: The role of bone morphogenetic proteins in endochondral bone formation.

  Cytekine Growth Factor Rev, 2005

  
• CTデータに基づく3D-CADモデルを利用した手術シミュレーションおよび術前ハイドロキシアパタイトインプラントの術前モデリング

  海渡 貴司; 名井 陽; 村瀬 剛; 妻木 範行; 冨田 哲也; 吉川 秀樹

  整形外科セラミック・インプラント研究会プログラム・抄録集, Dec. 2004

  
• Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis

  N Tsumaki; M Kakiuchi; J Sasaki; T Ochi; H Yoshikawa

  JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, Nov. 2004

  
• Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis

  N Tsumaki; M Kakiuchi; J Sasaki; T Ochi; H Yoshikawa

  JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, Nov. 2004

  
• Hypoxia promotes chondrocytic differentiation in vitro and cartilaginous matrix synthesis in organ culture via p38 kinase pathway

  M Hirao; N Tamai; N Tsumaki; A Myoui; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, Oct. 2004

  
• Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow

  R Katayama; S Wakitani; N Tsumaki; Y Morita; Matsushita, I; R Gejo; T Kimura

  RHEUMATOLOGY, Aug. 2004

  
• Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow

  R Katayama; S Wakitani; N Tsumaki; Y Morita; Matsushita, I; R Gejo; T Kimura

  RHEUMATOLOGY, Aug. 2004

  
• Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

  M Horiki; T Imamura; M Okamoto; M Hayashi; J Murai; A Myoui; T Ochi; K Miyazono; H Yoshikawa; N Tsumaki

  JOURNAL OF CELL BIOLOGY, May 2004

  
• Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

  M Horiki; T Imamura; M Okamoto; M Hayashi; J Murai; A Myoui; T Ochi; K Miyazono; H Yoshikawa; N Tsumaki

  JOURNAL OF CELL BIOLOGY, May 2004

  
• Overexpression of BMP4 in osteoblasts causes osteopenia in transgenic mice

  J Murai; N Tsumaki; M Horiki; Y Hashimoto; K Kuriyama; H Yoshikawa

  BONE, 2004

  
• Hypoxia promotes chondrocytic differentiation of C3H10T1/2 cells induced by bone morphogenetic protein-2

  M Hirao; N Tamai; N Tsumaki; A Myoui; H Yoshikawa

  BONE, 2004

  
• Overexpression of BMP4 in osteoblasts causes severe osteopenia in transgenic mice.

  N Tsumaki; M Horiki; Y Hashimoto; K Kuriyama; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2003

  
• Overexpression of Smad6 in chondrocytes distinctively disturbs terminal differentiation of chondrocytes and causes osteopenia in transgenic mice.

  M Horiki; N Tsumaki; A Myoui; T Imamura; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2003

  
• Role of Smad6 during cartilage formation

  M Horiki; N Tsumaki; A Myoui; T Miyaji; T Imamura; H Yoshikawa

  BONE, May 2003

  
• COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG

  Y Matsui; HA Chansky; F Barahmand-Pour; A Zielinska-Kwiatkowska; N Tsumaki; A Myoui; H Yoshikawa; L Yang; DR Eyre

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2003

  
• Role of bone morphogenetic protein signals during skeletal development

  N Tsumaki; M Horiki; T Kimura; H Yoshikawa

  ARTHRITIS RESEARCH & THERAPY, 2003

  
• Repair of rabbit articular cartilage defect using CDMP1-transfected autologous mesenchymal stem cell derived from bone marrow.

  R Katayama; S Wakitani; N Tsumaki; H Matsuno; L Frank; K Yudoh; T Kimura

  ARTHRITIS AND RHEUMATISM, Sep. 2002

  
• A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene (Retracted Article)

  K Tanaka; N Tsumaki; CA Kozak; Y Matsumoto; F Nakatani; Y Iwamoto; Y Yamada

  MOLECULAR AND CELLULAR BIOLOGY, Jun. 2002

  
• Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis

  N Tsumaki; T Nakase; T Miyaji; M Kakiuchi; T Kimura; T Ochi; H Yoshikawa

  JOURNAL OF BONE AND MINERAL RESEARCH, May 2002

  
• Matsui, Y., Araki, N., Tsuboi, H., Tsumaki, N., Nakata, K., Kawabata, H., Eyre, D. R., and Yoshikawa, H.: Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells.

  Anticancer Res, 2002

  
• Nakase, T., Sugamoto, K., Miyamoto, T., Tsumaki, N., Luyten, F. P., Inui, H., Myoui, A., Tomita, T., and Yoshikawa, H.: Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff.

  Clin Orthop, 2002

  
• Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum

  T Nakase; K Ariga; K Yonenobu; N Tsumaki; FP Luyten; Y Mukai; Sato, I; H Yoshikawa

  EUROPEAN SPINE JOURNAL, Aug. 2001

  
• Flagエピトープ標識II型コラーゲンCプロペプチド過剰発現マウスにおける外来遺伝子発現の免疫組織学的検索(Demonstration of type II collagen C-propeptide tagged with Flag epitope (DYKDDDDK) in cartilage of transgenic mice)

  松井 好人; 中田 研; 妻木 範行; 片岡 英一郎; 木村 友厚; Adachi Eijiro; Matsui Yoshito; Nakata Ken; Tsumaki Noriyuki; Kataoka Eiichiro; Kimura Tomoatsu

  解剖学雑誌, Feb. 2001

  
• Matsui, Y., Nakata, K., Araki, N., Ozono, K., Fujita, Y., Tsumaki, N., Kawabata, H., Yasui, N., Sekiguchi, K., and Yoshikawa, H.: Alternative splicing of fibronectin transcripts in osteochondrogenic tumors.

  Anticancer Res, 2001

  
• Involvement of Ptc/Gli-BMP signaling in the Periosteum in the Early Phase of Fracture Repair

  NAKASE T.

  日本整形外科學會雜誌, 25 Aug. 2000

  
• Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene

  Y Liu; HC Li; K Tanaka; N Tsumaki; Y Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2000

  
• A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia

  Y. Matsui; N. Yasui; H. Kawabata; K. Ozono; K. Nakata; T. Mizushima; N. Tsumaki; E. Kataoka; Y. Fujita; T. Ochi

  Journal of Human Genetics, Mar. 2000

  
• Tsumaki, N., Liu, Y., Yamada, Y., and Krebsbach, P.: Enhancer analysis of the 1(II) and 2(XI) collagen genes in transfected chondrocytes and transgenic mice.

  Methods Mol Biol, 2000

  
• Targeted gene expression in human articular cartilage by direct in vivo gene transfer into SCID-HuRAg mouse.

  R Katayama; T Tomita; N Tsumaki; T Ochi; H Matsuno; Y Morita; K Yudoh; F Nakazawa; T Kimura

  ARTHRITIS AND RHEUMATISM, Sep. 1999

  
• ヒト骨軟骨形成性疾患における CDMP (Cartilage-derived morphogenetic protein)-1 遺伝子の発現様式について

  中瀬 尚長; 金子 元春; 有賀 健太; 妻木 範行; 冨田 哲也; 菅本 一臣; 宮本 紳平; 名井 陽; 吉川 秀樹; 米延 策雄; 越智 隆弘

  日本骨代謝学会雑誌 = Japanese journal of bone metabolism, 26 Jun. 1999

  
• Role of CDMP-1 in skeletal morphogenesis: Promotion of mesenchymal cell recruitment and chondrocyte differentiation

  N Tsumaki; K Tanaka; E Arikawa-Hirasawa; T Nakase; T Kimura; JT Thomas; T Ochi; FP Luyten; Y Yamada

  JOURNAL OF CELL BIOLOGY, Jan. 1999

  
• Immunohistochemical detection of the foreign gene expression in transgenic mice overxpressing the FLAG epitope tagged chondrocalcin in cartilage

  Matsui Y; Nakata K; Adachi E; Kimura T; Tsumaki N; Katsumata O; Yasui N; Kataoka E; Fujita Y; Ochi T

  Connective tissue, 1999

  
• Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha 2(XI) collagen promoter

  N Tsumaki; T Kimura; K Tanaka; JH Kimura; T Ochi; Y Yamada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1998

  
• Inhibition of proliferation of synovial cells from patients with rheumatoid arthritis by overexpression of p21 gene through induction of apoptosis.

  T Tomita; E Takeuchi; N Tomita; R Morishita; M Kaneko; H Matsushita; H Takano; N Tsumaki; Y Kaneda; T Ochi

  ARTHRITIS AND RHEUMATISM, Sep. 1998

  
• Genes in joint disorders

  Kimura Tomoatsu; Tsumaki Noriyuki; Yasui Natsuo; Nakata Ken; Tomita Tetsuya; Kataoka Eiichiro; Ochi Takahiro

  Connective tissue, 1998

  
• Transcriptional regulatory cis-elements of α2(XI) collagen gene

  N. Tsumaki; T. Kimura; Y. Matsui; K. Nakata; T. Ochi

  Connective Tissue, 01 Jan. 1998

  
• Differential in situ Expression of Mouse Pro-a2(XI) Collagen during Development

  SUGIMOTO M

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Aug. 1997

  
• 軟骨マトリックスの異常と関節破壊

  木村 友厚; 田邊 誠; 中田 研; 妻木 範行; 松井 好人; 越智 隆弘

  リウマチ, 01 Apr. 1997

  
• Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage

  N Tsumaki; T Kimura; Y Matsui; K Nakata; T Ochi

  JOURNAL OF CELL BIOLOGY, Sep. 1996

  
• Promoter assay using transgenic mice reveals the presence of cis-acting elements governing tissue and site-specific expression of Col1a2.

  N Tsumaki; M Sugimoto; Y Matsui; K Nakata; T Ochi; T Kimura

  MATRIX BIOLOGY, Sep. 1996

  
• Alternative Splicing of the Primary Transcripts at the N-propeptide Coding Region of Human Pro-α1(XI) and Pro-α2(XI) Collagen in Cartilaginous Tumors

  MATSUI Y

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Aug. 1996

  
• Collagens and Osteo-chondrogenesis

  KIMURA T

  日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, 25 Aug. 1996

  
• マウス発生過程におけるXI型コラーゲンα2鎖 alternative splicing form の発現と局在

  杉本 瑞生; 妻木 範行; 松井 好人; 中田 研; 木村 友厚; 佐藤 宗彦; 川畑 浩久; 野村 慎太郎; 越智 隆弘

  日本骨代謝学会雑誌 = Japanese journal of bone metabolism, 01 Jun. 1996

  
• PROGRESSIVE DEGENERATION OF ARTICULAR-CARTILAGE AND INTERVERTEBRAL DISCS IN TRANSGENIC MICE BEARING A TYPE-IX COLLAGEN MUTATION

  T KIMURA; K NAKATA; N TSUMAKI; Y MATSUI; T OCHI

  ARTHRITIS AND RHEUMATISM, Sep. 1995

  
• Tsumaki, N., and Kimura, T.: Differential expression of an acidic domain in the amino-terminal propeptide of mouse pro-2(XI) collagen by complex alternative splicing.

  J Biol Chem, 1995

  
• 骨軟骨コラーゲン異常モデルマウス

  中田 研; 妻木 範行; 木村 友厚

  Molecular Medicine, Dec. 1994

  

Works

• 厚生労働科学研究費補助金 免疫アレルギー疾患予防・治療研究事業

  From 2006

  
• 超音波刺激，人工骨，骨形成因子（BMP）シグナル操作を組み合わせた骨欠損の修復

  From 2006

  
• 軟骨細胞シグナリングとマトリックス転写制御による軟骨形成・分化の解明

  From 2006

  
• 難治性骨折治癒過程におけるBMPシグナル作用機構の解明

  From 2005

  

Education

Teaching subject(s)

• From Apr. 2020, To Mar. 2021

  Frontier in Life Sciences

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Frontier in Life Sciences

  Fall, 生命科学研究科

Participation in PhD Defense

• In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells

  YOSHIMATSU MASAYOSHI, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy

  HARUTIUN MINAS NALBANDIAN GEYMONAT, Graduate School of Medicine, Chief Examiner

  26 Jul. 2021

Administration

School management (title, position)

• From 01 Apr. 2015, To 31 Mar. 2017

  組換えDNA実験安全委員会 1号委員
• From 01 Oct. 2018, To 30 Sep. 2020

  京都大学動物実験委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  京都大学動物実験委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  白眉センター委員会
• From 01 Oct. 2020, To 31 Mar. 2021

  京都大学動物実験委員会 委員

Faculty management (title, position)

• From 01 Apr. 2016, To 31 Mar. 2018

  組換えDNA実験安全委員会4号委員
• From 01 Oct. 2016, To 30 Sep. 2018

  医学研究科運営委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  動物飼育施設長
• From 01 Apr. 2019, To 31 Mar. 2021

  動物実験委員会1号委員
• From 23 Jan. 2020, To 31 Mar. 2021

  動物実験施設運営委員会1号委員
• From 01 Apr. 2021, To 31 Mar. 2023

  動物実験委員会2号委員