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Shimamura, Tatsuro

Graduate School of Medicine, Medicine Program-Specific Senior Lecturer/Program-Specific Junior Associate Professor

Shimamura, Tatsuro
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    Last Updated :2022/06/30

    Basic Information

    Academic Degree

    • 修士(農学)(東京大学)
    • 博士(農学)(東京大学)

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    list
      Last Updated :2022/06/30

      Research

      Research Topics, Overview of the research

      • Research Topics

        Structural studies of membrane proteins
      • Overview of the research

        Proteins play important roles in various functions of the living cells. The structural information of the proteins is essential for understanding the functions of the proteins. The aims of my research include the elucidations of the 3D structure of membrane proteins and the mechanism of conformational changes of proteins as well as the structure-based design of new ligands.

      Papers

      • 4YOP: CRYSTAL STRUCTURE OF HEN EGG-WHITE LYSOZYME
        Nakane T; Song C; Suzuki M; Nango E; Kobayashi J; Masuda T; Inoue S; Mizohata E; Nakatsu T; Tanaka T; Tanaka R; Shimamura T; Tono K; Joti Y; Kameshima T; Hatsui T; Yabashi M; Nureki O; Iwata S; Sugahara M
        Worldwide Protein Data Bank, 2015, Peer-reviewed
      • Molecular Basis of Alternating Access Membrane Transport by the Sodium-hydantoin Transporter Mhp1
        SHIMAMURA Tatsuro; IWATA So
        Seibutsu Butsuri, 2011
      • Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin.
        Kazumasa Oda; Takashi Nomura; Takanori Nakane; Keitaro Yamashita; Keiichi Inoue; Shota Ito; Johannes Vierock; Kunio Hirata; Andrés D Maturana; Kota Katayama; Tatsuya Ikuta; Itsuki Ishigami; Tamaki Izume; Rie Umeda; Ryuun Eguma; Satomi Oishi; Go Kasuya; Takafumi Kato; Tsukasa Kusakizako; Wataru Shihoya; Hiroto Shimada; Tomoyuki Takatsuji; Mizuki Takemoto; Reiya Taniguchi; Atsuhiro Tomita; Ryoki Nakamura; Masahiro Fukuda; Hirotake Miyauchi; Yongchan Lee; Eriko Nango; Rie Tanaka; Tomoyuki Tanaka; Michihiro Sugahara; Tetsunari Kimura; Tatsuro Shimamura; Takaaki Fujiwara; Yasuaki Yamanaka; Shigeki Owada; Yasumasa Joti; Kensuke Tono; Ryuichiro Ishitani; Shigehiko Hayashi; Hideki Kandori; Peter Hegemann; So Iwata; Minoru Kubo; Tomohiro Nishizawa; Osamu Nureki
        eLife, 23 Mar. 2021, Peer-reviewed
      • S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.
        Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara
        Cell chemical biology, 02 Feb. 2021, Peer-reviewed
      • Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone.
        Dohyun Im; Asuka Inoue; Takaaki Fujiwara; Takanori Nakane; Yasuaki Yamanaka; Tomoko Uemura; Chihiro Mori; Yuki Shiimura; Kanako Terakado Kimura; Hidetsugu Asada; Norimichi Nomura; Tomoyuki Tanaka; Ayumi Yamashita; Eriko Nango; Kensuke Tono; Francois Marie Ngako Kadji; Junken Aoki; So Iwata; Tatsuro Shimamura
        Nature communications, 22 Dec. 2020, Peer-reviewed, Last author, Corresponding author
      • The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone
        Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Kunio Hirata; Yuki Shiimura; Dohyun Im; Tatsuro Shimamura; Norimichi Nomura; Hiroko Iwanari; Takao Hamakubo; Osamu Kusano-Arai; Hiromi Hisano; Tomoko Uemura; Chiyo Suno; Junken Aoki; So Iwata
        Structure, Dec. 2019, Peer-reviewed
      • Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus
        Mihoko Takenoya; Tatsuro Shimamura; Ryuji Yamanaka; Yuya Adachi; Shinsaku Ito; Yasuyuki Sasaki; Akira Nakamura; Shunsuke Yajima
        Acta Crystallographica Section F Structural Biology Communications, 01 Sep. 2019, Peer-reviewed
      • Structures of the 5-HT 2A receptor in complex with the antipsychotics risperidone and zotepine
        Kanako Terakado Kimura; Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Dohyun Im; Chihiro Mori; Takatoshi Arakawa; Kunio Hirata; Yayoi Nomura; Norimichi Nomura; Junken Aoki; So Iwata; Tatsuro Shimamura
        Nature Structural and Molecular Biology, 01 Feb. 2019, Peer-reviewed, Last author, Corresponding author
      • High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure
        Shimazu Y; Tono K; Tanaka T; Yamanaka Y; Nakane T; Mori C; Terakado Kimura K; Fujiwara T; Sugahara M; Tanaka R; Doak RB; Shimamura T; Iwata S; Nango E; Yabashi M
        J. Appl. Cryst., 2019, Peer-reviewed
      • Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.
        Asada H; Horita S; Hirata K; Shiroishi M; Shiimura Y; Iwanari H; Hamakubo T; Shimamura T; Nomura N; Kusano-Arai O; Uemura T; Suno C; Kobayashi T; Iwata S
        Nature structural & molecular biology, Jul. 2018, Peer-reviewed
      • Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
        Ryoji Suno; Kanako Terakado Kimura; Takanori Nakane; Keitaro Yamashita; Junmei Wang; Takaaki Fujiwara; Yasuaki Yamanaka; Dohyun Im; Shoichiro Horita; Hirokazu Tsujimoto; Maki S Tawaramoto; Takatsugu Hirokawa; Eriko Nango; Kensuke Tono; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Makina Yabashi; Keiko Shimamoto; Masaki Yamamoto; Daniel M Rosenbaum; So Iwata; Tatsuro Shimamura; Takuya Kobayashi
        Structure (London, England : 1993), 02 Jan. 2018, Peer-reviewed, Corresponding author
      • A three-dimensional movie of structural changes in bacteriorhodopsin
        Eriko Nango; Antoine Royant; Minoru Kubo; Takanori Nakane; Cecilia Wickstrand; Tetsunari Kimura; Tomoyuki Tanaka; Kensuke Tono; Changyong Song; Rie Tanaka; Toshi Arima; Ayumi Yamashita; Jun Kobayashi; Toshiaki Hosaka; Eiichi Mizohata; Przemyslaw Nogly; Michihiro Sugahara; Daewoong Nam; Takashi Nomura; Tatsuro Shimamura; Dohyun Im; Takaaki Fujiwara; Yasuaki Yamanaka; Byeonghyun Jeon; Tomohiro Nishizawa; Kazumasa Oda; Masahiro Fukuda; Rebecka Andersson; Petra Bath; Robert Dods; Jan Davidsson; Shigeru Matsuoka; Satoshi Kawatake; Michio Murata; Osamu Nureki; Shigeki Owada; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Gebhard Schertler; Makina Yabashi; Ana-Nicoleta Bondar; Jorg Standfuss; Richard Neutze; So Iwata
        SCIENCE, Dec. 2016, Peer-reviewed
      • Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent
        Takanori Nakane; Shinya Hanashima; Mamoru Suzuki; Haruka Saiki; Taichi Hayashi; Keisuke Kakinouchi; Shigeru Sugiyama; Satoshi Kawatake; Shigeru Matsuoka; Nobuaki Matsumori; Eriko Nango; Jun Kobayashi; Tatsuro Shimamura; Kanako Kimura; Chihiro Mori; Naoki Kunishima; Michihiro Sugahara; Yoko Takakyu; Shigeyuki Inoue; Tetsuya Masuda; Toshiaki Hosaka; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Tsuyoshi Inoue; Osamu Nureki; So Iwata; Michio Murata; Eiichi Mizohata
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2016, Peer-reviewed
      • High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1
        Shoichiro Horita; Yayoi Nomura; Yumi Sato; Tatsuro Shimamura; So Iwata; Norimichi Nomura
        SCIENTIFIC REPORTS, Oct. 2016, Peer-reviewed
      • Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
        Yasuaki Kabe; Takanori Nakane; Ikko Koike; Tatsuya Yamamoto; Yuki Sugiura; Erisa Harada; Kenji Sugase; Tatsuro Shimamura; Mitsuyo Ohmura; Kazumi Muraoka; Ayumi Yamamoto; Takeshi Uchida; So Iwata; Yuki Yamaguchi; Elena Krayukhina; Masanori Noda; Hiroshi Handa; Koichiro Ishimori; Susumu Uchiyama; Takuya Kobayashi; Makoto Suematsu
        NATURE COMMUNICATIONS, Mar. 2016, Peer-reviewed
      • Structure and Mechanism of the Mammalian Fructose Transporter GLUT5
        Gregory Verdon; Norimichi Nomura; Hae Joo Kang; Tatsuro Shimamura; Yayoi Nomura; Saba Abdul Hussien; Aziz Abdul Qureshi; Mathieu Coincon; Yumi Sato; Yoshiko Nakada-Nakura; Takeshi Murata; Takuya Kobayashi; Michihiro Kasahara; So Iwata; David Drew
        BIOPHYSICAL JOURNAL, Feb. 2016, Peer-reviewed
      • 5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA
        Nakane T; Hanashima S; Suzuki M; Saiki H; Hayashi T; Kakinouchi K; Sugiyama S; Kawatake S; Matsuoka S; Matsumori N; Nango E; Kobayashi J; Shimamura T; Kimura K; Mori C; Kunishima N; Sugahara M; Takakyu Y; Inoue S; Masuda T; Hosaka T; Tono K; Joti Y; Kameshima T; Hatsui T; Yabashi M; Inoue T; Nureki O; Iwata S; Murata M; Mizohata E
        Worldwide Protein Data Bank, 2016, Peer-reviewed
      • Native sulfur/chlorine SAD phasing for serial femtosecond crystallography
        Takanori Nakane; Changyong Song; Mamoru Suzuki; Eriko Nango; Jun Kobayashi; Tetsuya Masuda; Shigeyuki Inoue; Eiichi Mizohata; Toru Nakatsu; Tomoyuki Tanaka; Rie Tanaka; Tatsuro Shimamura; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Osamu Nureki; So Iwata; Michihiro Sugahara
        ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Dec. 2015, Peer-reviewed
      • Structure and mechanism of the mammalian fructose transporter GLUT5
        Norimichi Nomura; Gregory Verdon; Hae Joo Kang; Tatsuro Shimamura; Yayoi Nomura; Yo Sonoda; Saba Abdul Hussien; Aziz Abdul Qureshi; Mathieu Coincon; Yumi Sato; Hitomi Abe; Yoshiko Nakada-Nakura; Tomoya Hino; Takatoshi Arakawa; Osamu Kusano-Arai; Hiroko Iwanari; Takeshi Murata; Takuya Kobayashi; Takao Hamakubo; Michihiro Kasahara; So Iwata; David Drew
        NATURE, Oct. 2015, Peer-reviewed
      • Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser
        Kensuke Tono; Eriko Nango; Michihiro Sugahara; Changyong Song; Jaehyun Park; Tomoyuki Tanaka; Rie Tanaka; Yasumasa Joti; Takashi Kameshima; Shun Ono; Takaki Hatsui; Eiichi Mizohata; Mamoru Suzuki; Tatsuro Shimamura; Yoshiki Tanaka; So Iwata; Makina Yabashi
        JOURNAL OF SYNCHROTRON RADIATION, May 2015, Peer-reviewed
      • Native sulfur/chlorine SAD phasing for serial femtosecond crystallography
        Takanori Nakane; Changyong Song; Mamoru Suzuki; Eriko Nango; Jun Kobayashi; Tetsuya Masuda; Shigeyuki Inoue; Eiichi Mizohata; Toru Nakatsu; Tomoyuki Tanaka; Rie Tanaka; Tatsuro Shimamura; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Osamu Nureki; So Iwata; Michihiro Sugahara
        Acta Crystallographica Section D: Biological Crystallography, 2015, Peer-reviewed
      • Grease matrix as a versatile carrier of proteins for serial crystallography
        Michihiro Sugahara; Eiichi Mizohata; Eriko Nango; Mamoru Suzuki; Tomoyuki Tanaka; Tetsuya Masudala; Rie Tanaka; Tatsuro Shimamura; Yoshiki Tanaka; Chiyo Suno; Kentaro Ihara; Dongqing Pan; Keisuke Kakinouchi; Shigeru Sugiyama; Michio Murata; Tsuyoshi Inoue; Kensuke Tono; Changyong Song; Jaehyun Park; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Makina Yabashi; So Iwata
        NATURE METHODS, Jan. 2015, Peer-reviewed
      • Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor
        Suharni; Yayoi Nomura; Takatoshi Arakawa; Tomoya Hino; Hitomi Abe; Yoshiko Nakada-Nakura; Yumi Sato; Hiroko Iwanari; Mitsunori Shiroishi; Hidetsugu Asada; Tatsuro Shimamura; Takeshi Murata; Takuya Kobayashi; Takao Hamakubo; So Iwata; Norimichi Nomura
        Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Dec. 2014, Peer-reviewed
      • Crystal Structure of a Symmetric Football-Shaped GroEL:GroES(2)-ATP(14) Complex Determined at 3.8 angstrom Reveals Rearrangement between Two GroEL Rings
        Ayumi Koike-Takeshita; Takatoshi Arakawa; Hideki Taguchi; Tatsuro Shimamura
        JOURNAL OF MOLECULAR BIOLOGY, Oct. 2014, Peer-reviewed, Corresponding author
      • [X-ray structure of histamine H1 receptor].
        Shimamura T
        Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Jul. 2014, Peer-reviewed, Invited, Lead author, Last author, Corresponding author
      • [Structural biology and molecular targets].
        Shimamura T; Iwata S
        Nihon rinsho. Japanese journal of clinical medicine, Nov. 2012, Peer-reviewed, Invited, Lead author
      • Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH
        Ryoji Suno; Masakazu Shimoyama; Akiko Abe; Tatsuro Shimamura; Natsuka Shimodate; Yo-hei Watanabe; Yoshinori Akiyama; Masasuke Yoshida
        FEBS LETTERS, Sep. 2012, Peer-reviewed
      • Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae
        Mitsunori Shiroishi; Hirokazu Tsujimoto; Hisayoshi Makyio; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Takeshi Murata; Norimichi Nomura; Tatsuya Haga; So Iwata; Takuya Kobayashi
        MICROBIAL CELL FACTORIES, Jun. 2012, Peer-reviewed
      • G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
        Tomoya Hino; Takatoshi Arakawa; Hiroko Iwanari; Takami Yurugi-Kobayashi; Chiyo Ikeda-Suno; Yoshiko Nakada-Nakura; Osamu Kusano-Arai; Simone Weyand; Tatsuro Shimamura; Norimichi Nomura; Alexander D. Cameron; Takuya Kobayashi; Takao Hamakubo; So Iwata; Takeshi Murata
        NATURE, Feb. 2012, Peer-reviewed
      • Structure of histamine H1 receptor
        Tatsuro Shimamura
        Seikagaku, 2012, Peer-reviewed, Invited, Lead author, Last author, Corresponding author
      • Production of the stable human histamine H-1 receptor in Pichia pastoris for structural determination
        Mitsunori Shiroishi; Takuya Kobayashi; Satoshi Ogasawara; Hirokazu Tsujimoto; Chiyo Ikeda-Suno; So Iwata; Tatsuro Shimamura
        METHODS, Dec. 2011, Peer-reviewed, Last author, Corresponding author
      • Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H-1 Receptor
        Chris de Graaf; Albert J. Kooistra; Henry F. Vischer; Vsevolod Katritch; Martien Kuijer; Mitsunori Shiroishi; So Iwata; Tatsuro Shimamura; Raymond C. Stevens; Iwan J. P. de Esch; Rob Leurs
        JOURNAL OF MEDICINAL CHEMISTRY, Dec. 2011, Peer-reviewed
      • Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium
        Natsuko Tokuda; Kiyohiko Igarashi; Tatsuro Shimamura; Takami Yurugi-Kobayashi; Mitsunori Shiroishi; Keisuke Ito; Taishi Sugawara; Hidetsugu Asada; Takeshi Murata; Norimichi Nomura; So Iwata; Takuya Kobayashi
        PROTEIN EXPRESSION AND PURIFICATION, Sep. 2011, Peer-reviewed, Lead author
      • Structure of the human histamine H-1 receptor complex with doxepin
        Tatsuro Shimamura; Mitsunori Shiroishi; Simone Weyand; Hirokazu Tsujimoto; Graeme Winter; Vsevolod Katritch; Ruben Abagyan; Vadim Cherezov; Wei Liu; Gye Won Han; Takuya Kobayashi; Raymond C. Stevens; So Iwata
        NATURE, Jul. 2011, Peer-reviewed, Lead author
      • Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis
        Hidetsugu Asada; Tomoko Uemura; Takami Yurugi-Kobayashi; Mitsunori Shiroishi; Tatsuro Shimamura; Hirokazu Tsujimoto; Keisuke Ito; Taishi Sugawara; Takanori Nakane; Norimichi Nomura; Takeshi Murata; Tatsuya Haga; So Iwata; Takuya Kobayashi
        MICROBIAL CELL FACTORIES, Apr. 2011, Peer-reviewed
      • Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans
        Keisuke Ito; Sohei Ito; Tatsuro Shimamura; Simone Weyand; Yasuaki Kawarasaki; Takumi Misaka; Keiko Abe; Takuya Kobayashi; Alexander D. Cameron; So Iwata
        JOURNAL OF MOLECULAR BIOLOGY, Apr. 2011, Peer-reviewed, Lead author
      • The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1
        Simone Weyand; Tatsuro Shimamura; Oliver Beckstein; Mark S. P. Sansom; So Iwata; Peter J. F. Henderson; Alexander D. Cameron
        JOURNAL OF SYNCHROTRON RADIATION, Jan. 2011, Peer-reviewed
      • Towards structure determination for G protein-coupled receptor
        Takuya Kobayashi; Mitsunori Shiroishi; Tatsuro Shimamura; Takami Yurugi; Hidetsugu Asada; Tomoya Hino; Takatoshi Arakawa; Takeshi Murata; Norimichi Nomura; So Iwata
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Peer-reviewed
      • Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein
        Keisuke Ito; Taishi Sugawara; Ayako Koizumi; Ken-ichiro Nakajima; Akiko Shimizu-Ibuka; Mitsunori Shiroishi; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Tomiko Asakura; Takumi Misaka; So Iwata; Takuya Kobayashi; Keiko Abe
        BIOTECHNOLOGY LETTERS, Jan. 2011, Peer-reviewed
      • Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans
        Keisuke Ito; Sohei Ito; Tatsuro Shimamura; Yasuaki Kawarasaki; Keiko Abe; Takumi Misaka; Takuya Kobayashi; So Iwata
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Sep. 2010, Peer-reviewed
      • Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin
        Keisuke Ito; Taishi Sugawara; Ayako Koizumi; Ken-ichiro Nakajima; Akiko Shimizu-Ibuka; Mitsunori Shiroishi; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Tomiko Asakura; Katsuyoshi Masuda; Masaji Ishiguro; Takumi Misaka; So Iwata; Takuya Kobayashi; Keiko Abe
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Sep. 2010, Peer-reviewed
      • Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1
        Tatsuro Shimamura; Simone Weyand; Oliver Beckstein; Nicholas G. Rutherford; Jonathan M. Hadden; David Sharples; Mark S. P. Sansom; So Iwata; Peter J. F. Henderson; Alexander D. Cameron
        SCIENCE, Apr. 2010, Peer-reviewed, Lead author
      • The catalytic efficiency (k(cat)/K-m) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog
        Yasushi Nitanai; Tatsuro Shimamura; Takuro Uchiyama; Yoshikazu Ishii; Michiyo Takehira; Katsuhide Yutani; Hiroshi Matsuzawa; Masashi Miyano
        BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Apr. 2010, Peer-reviewed
      • Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae
        Taishi Sugawara; Keisuke Ito; Mitsunori Shiroishi; Natsuko Tokuda; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Takumi Misaka; Norimichi Nomura; Takeshi Murata; Keiko Abe; So Iwata; Takuya Kobayashi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2009, Peer-reviewed
      • Improvement of crystal quality by surface mutations of beta-lactamase Toho-1
        Tatsuro Shimamura; Yasushi Nitanai; Takuro Uchiyama; Hiroshi Matsuzawa
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Apr. 2009, Peer-reviewed, Lead author, Corresponding author
      • Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris
        Takami Yurugi-Kobayashi; Hidetsugu Asada; Mitsunori Shiroishi; Tatsuro Shimamura; Saeko Funamoto; Naoko Katsuta; Keisuke Ito; Taishi Sugawara; Natsuko Tokuda; Hirokazu Tsujimoto; Takeshi Murata; Norimichi Nomura; Kazuko Haga; Tatsuya Haga; So Iwata; Takuya Kobayashi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2009, Peer-reviewed
      • Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens
        Tatsuro Shimamura; Shunsuke Yajima; Shun'ichi Suzuki; Nicholas G. Rutherford; John O'Reilly; Peter J. F. Henderson; So Iwata
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Dec. 2008, Peer-reviewed, Lead author
      • Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter
        Simone Weyand; Tatsuro Shimamura; Shunsuke Yajima; Shun' ichi Suzuki; Osman Mirza; Kuakarun Krusong; Elisabeth P. Carpenter; Nicholas G. Rutherford; Jonathan M. Hadden; John O' Reilly; Pikyee Ma; Massoud Saidijam; Simon G. Patching; Ryan J. Hope; Halina T. Norbertczak; Peter C. J. Roach; So Iwata; Peter J. F. Henderson; Alexander D. Cameron
        SCIENCE, Oct. 2008, Peer-reviewed, Lead author
      • Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae
        Keisuke Ito; Taishi Sugawara; Mitsunori Shiroishi; Natsuko Tokuda; Azusa Kurokawa; Takumi Misaka; Hisayoshi Makyio; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Norimichi Nomura; Takeshi Murata; Keiko Abe; So Iwata; Takuya Kobayashi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2008, Peer-reviewed
      • Molecular mechanism of energy conservation in polysulfide respiration
        Mika Jormakka; Ken Yokoyama; Takahiro Yano; Masatada Tamakoshi; Satoru Akimoto; Tatsuro Shimamura; Paul Curmi; So Iwata
        NATURE STRUCTURAL & MOLECULAR BIOLOGY, Jul. 2008, Peer-reviewed
      • Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region
        Tatsuro Shimamura; Kenji Hiraki; Naoko Takahashi; Tetsuya Hori; Hideo Ago; Katsuyoshi Masuda; Koji Takio; Masaji Ishiguro; Masashi Miyano
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2008, Peer-reviewed, Lead author
      • Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
        Hideo Ago; Yoshihide Kanaoka; Daisuke Irikura; Bing K. Lam; Tatsuro Shimamura; K. Frank Austen; Masashi Miyano
        NATURE, Aug. 2007, Peer-reviewed
      • Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: Contribution of cross-domain polar networks to thermostability
        Hitoshi Nakayama; Tatsuro Shimamura; Takahito Imagawa; Nobuaki Shirai; Takashi Itoh; Yoshihiko Sako; Masashi Miyano; Haruhiko Sakuraba; Toshihisa Ohshima; Norimichi Nomura; Hideaki Tsuge
        JOURNAL OF MOLECULAR BIOLOGY, Jan. 2007, Peer-reviewed
      • Leu(309) plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL
        A Koike-Takeshita; T Shimamura; K Yokoyama; M Yoshida; H Taguchi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2006, Peer-reviewed
      • Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity
        T Shimamura; A Koike-Takeshita; K Yokoyama; R Masui; N Murai; M Yoshida; H Taguchi; S Iwata
        STRUCTURE, Aug. 2004, Peer-reviewed, Lead author
      • Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K+ channel from Rattus norvegicus
        T Shimamura; O Shamotienko; S Akhtar; JO Dolly; S Iwata
        ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, May 2004, Peer-reviewed, Lead author
      • Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8
        T Shimamura; A Koike-Takeshita; K Yokoyama; M Yoshida; H Taguchi; S Iwata
        ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Sep. 2003, Peer-reviewed, Lead author
      • Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin
        T Shimamura; A Ibuka; S Fushinobu; T Wakagi; M Ishiguro; Y Ishii; H Matsuzawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2002, Peer-reviewed, Lead author, Corresponding author

      Misc.

      • X線自由電子レーザーによるチャネルロドプシンの時分割構造解析
        小田和正; 野村高志; 野村高志; 中根崇智; 中根崇智; 西澤知宏; 久保稔; 久保稔; 南後恵理子; 南後恵理子; 島村達郎; 石神一貴; 生田達也; 井爪珠希; 江熊龍雲; 岩田想; 岩田想; 濡木理
        日本細胞生物学会大会(Web), 2019
      • X線自由電子レーザーによるチャネルロドプシンの時分割構造解析
        小田和正; 野村高志; 野村高志; 中根崇智; 西澤知宏; 久保稔; 久保稔; 南後恵理子; 南後恵理子; 島村達郎; 岩田想; 濡木理
        日本結晶学会年会講演要旨集, 2019
      • XFEL連続フェムト秒結晶構造解析:構造生物学の新時代
        溝端栄一; 福田庸太; 鈴木守; 鈴木守; 南後恵理子; 菅原道泰; 矢橋牧名; 登野健介; 城地保昌; 島村達郎; PANG Dongqing; CHAVAS Leonard M.G.; 西澤知宏; 松村浩由; 林高史; 的場康幸; 杉山成; 村田道雄; 高木淳一; 井上豪; 岩田想
        日本蛋白質科学会年会プログラム・要旨集, 2014
      • 自由電子レーザーを用いた膜蛋白質の系統的構造解析
        岩田想; 岩田想; 木村香菜子; 島村達郎; 南後恵理子; 田中智之; 西澤知宏; 濡木理; 田中里枝; 鈴木守; 鈴木守; 桝田哲哉; 桝田哲哉; 菅原道泰; 登野健介; 城地保昌; 亀島敬; SONG Changyong; 初井宇記; 矢橋牧名; 山下恵太郎; 保坂俊彰; 田辺弘明; 羽藤正勝; 有馬登志; 染谷友美; 白水美香子; 潘東青; 中津亨; 加藤博章; 溝端栄一; 北郷悠; 高木淳一; 山中保明; 藤原孝彰; 山下鮎美; 小林淳
        日本分子生物学会年会プログラム・要旨集(Web), 2014
      • 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発
        中根崇智; 花島慎弥; 鈴木守; 鈴木守; 斎木悠; 林太一; 垣之内啓介; 垣之内啓介; 杉山成; 杉山成; 川竹悟史; 川竹悟史; 松岡茂; 松岡茂; 松森信明; 南後恵理子; 小林淳; 島村達郎; 木村香菜子; 森千寿; 国島直樹; 菅原道泰; 高久陽子; 井上茂之; 井上茂之; 桝田哲哉; 桝田哲哉; 保坂俊彰; 登野健介; 城地保昌; 亀島敬; 初井宇記; 矢橋牧名; 井上豪; 濡木理; 岩田想; 岩田想; 村田道雄; 村田道雄; 溝端栄一
        日本結晶学会年会講演要旨集, 17 Nov. 2016
      • シリアルフェムト秒X線結晶構造解析のための試料調製方法
        田中智之; 菅原道泰; 山下鮎美; 小林淳; 田中里枝; 登野健介; 城地保昌; 亀島敬; PARK Jaehyun; SONG Changyong; 初井宇記; 矢橋牧名; 潘東青; 島村達郎; 溝端栄一; 岩田想; 南後恵理子
        日本蛋白質科学会年会プログラム・要旨集, 26 May 2015
      • AAA+プロテアーゼFtsHのATP依存的な構造変化にともなう基質ポリペプチド鎖分解メカニズム
        SUNO RYOJI; SHIMAMURA TATSURO; ABE AKIKO; HINO TOMOYA; WATANABE YOHEI; SHIMODATE NATSUKA; AKIYAMA YOSHINORI; IWATA SO; YOSHIDA MASASUKE
        日本蛋白質科学会年会プログラム・要旨集, 31 May 2013
      • Strategy for the structure determination of G protein-coupled receptor
        Takuya Kobayashi; Mitsunori Shiroishi; Hidetsugu Asada; Takami Yurugi; Tatsuro Shimamura; So Iwate
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012
      • 膜結合型AAA+プロテアーゼFtsHのATP結合による基質ポリペプチド分解メカニズム
        SUNO RYOJI; SHIMAMURA TATSURO; ABE AKIKO; HINO TOMOYA; SHIMODATE NATSUKA; WATANABE YOHEI; AKIYAMA YOSHINORI; IWATA SO; YOSHIDA MASASUKE
        日本生化学会大会(Web), 2012
      • Molecular Basis of the "Alternate Access Model" in the Cation-Substrate Symporter Mhp1 from Computer Simulations and X-Ray Crystallography
        Oliver Beckstein; Tatsuro Shimamura; Simone Weyand; Nicholas G. Rutherford; Jonathan M. Hadden; David Sharples; So Iwata; Peter J. F. Henderson; Alexander D. Cameron; Mark S. P. Sansom
        BIOPHYSICAL JOURNAL, Jan. 2010

      Presentations

      • X線自由電子レーザーを用いたGPCRの構造解析
        島村達郎
        第16回日本蛋白質科学会年会, 08 Jun. 2016, Invited
      • ヒスタミンH1受容体の構造解析とin silico screening
        島村達郎
        第87回日本内分泌学会学術総会, 25 Apr. 2014, Invited
      • Crystal structure of Histamine H1 receptor and drug design.
        Tatsuro Shimamura
        The 11th International Symposium for Future Drug Discovery and Medical Care, 02 Aug. 2013, Invited
      • ヒスタミンH1受容体の構造により解明された抗ヒスタミン薬選択性機構
        島村達郎
        第34回生体膜と薬物の相互作用シンポジウム, 15 Nov. 2012, Invited
      • キュービックフェーズ法による膜タンパク質の結晶化
        島村達郎
        蛋白研セミナー, 21 Sep. 2012, Invited
      • 膜蛋白質の結晶化
        島村達郎
        第12回 日本蛋白質科学会年会, 20 Jun. 2012, Invited
      • ヒト由来ヒスタミンH1受容体の立体構造
        島村達郎
        第9回 GPCR研究会, 11 May 2012, Invited
      • Structural studies of human G-protein coupled receptors.
        島村達郎
        日本農芸化学会2012年度大会, 25 Mar. 2012, Invited
      • 微結晶を用いた創薬ターゲット膜タンパク質の構造解析とSACLAの可能性
        島村達郎
        第25回日本放射光学会年会放射光科学合同シンポジウム, 09 Jan. 2012, Invited
      • ヒト由来ヒスタミン受容体H1の構造解析戦略
        島村達郎; 白石充典; Katritch V; Cherezov V; 小林拓也; Stevens RC; 岩田想
        第84回日本生化学会大会, 24 Sep. 2011, Invited
      • ヒダントイン輸送体Mhp1の基質輸送中の動き
        島村達郎; 岩田想
        生理研研究会, 08 Sep. 2011, Invited
      • Structure of a nucleobase-cation-symport transporter, Mhp1.
        Tatsuro Shimamura
        The 8th China-Japan Symposium on Drug Design and Development., 04 Nov. 2008, Invited
      • Serial Femtosecond crystallography using LCP crystals at SACLA
        Tatsuro Shimamura
        AsCA 2018/CRYSTAL 32, 02 Dec. 2018, The Asian Crystallographic Association, Invited
      • Structure of the human histamine H1 receptor with doxepin.
        Tatsuro Shimamura
        International Union of Crystallography, XXII Congress and General Assembly., 29 Aug. 2011, International Union of Crystallography, Invited

      Industrial Property Rights

      • 特許第5750700号, 特開2013-183660, 特願2012-049812, アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体
        小笠原 諭; 日野 智也; 島村 達郎; 荒川 孝俊; 万木 貴美; 寿野 千代; 村田 武士; 小林 拓也; 岩田 想
      • 特開2013-183660, 特願2012-049812, アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体
        小笠原 諭; 日野 智也; 島村 達郎; 荒川 孝俊; 万木 貴美; 寿野 千代; 村田 武士; 小林 拓也; 岩田 想

      External funds: Kakenhi

      • 新規抗精神病薬の開発に役立てることを目指したアミン受容体の構造解析
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43020:Structural biochemistry-related
        Kyoto University
        島村 達郎
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        受容体;構造解析
      • Gタンパク質共役型受容体の動的構造解析への挑戦
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Kyoto University
        島村 達郎
        From 30 Jul. 2020, To 31 Mar. 2022, Granted
        受容体;X線自由電子レーザー
      • GPCRのバイアス型シグナル機構の構造基盤
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43020:Structural biochemistry-related
        Kyoto University
        島村 達郎
        From 01 Apr. 2018, To 31 Mar. 2021, Granted
        Gタンパク質共役型受容体;受容体;X線;シグナル伝達
      • Structure determination of GPCRs using CryoEM.
        Grant-in-Aid for Challenging Research (Exploratory)
        Kyoto University
        Tatsuro Shimamura
        From 30 Jun. 2017, To 31 Mar. 2019, Project Closed
        構造解析;GPCR;電子顕微鏡;G蛋白質共役型受容体
      • Studies on the structure and function of a xenobiotic ABC transporter
        Grant-in-Aid for Scientific Research (C)
        Tokyo University of Agriculture
        SHUNSUKE YAJIMA
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        X線結晶構造解析;コンフォメーション変化;非天然化合物;ゲノム解析
      • Crystallographic study of the mammalian bile acid transporter NTCP in complex with its conformation-specific antibodies
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Norimichi Nomura
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        膜タンパク質;抗体;X線結晶構造解析;創薬ターゲット;高脂血症;胆汁酸;トランスポーター;コレステロール;膜蛋白質
      • Trial for determining the structure of CXCR7
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Tatsuro Shimamura
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        結晶構造解析;Gタンパク質共役型受容体;シグナル伝達;タンパク質;G蛋白質共役型受容体;蛋白質;癌
      • X-ray crystallographic analyses of human serotonin receptors for structure-based drug discovery.
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Kanako Kimura
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        ヒト膜タンパク質;X線結晶構造解析;ヒト膜受容体;ヒト膜蛋白質
      • 立体構造に基づくGPCRとリガンドの相互作用の解明
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Kyoto University
        島村 達郎
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        GPCR;リガンド
      • Structure determination of human membrane transporters
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Tatsuro SHIMAMURA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        膜輸送体;結晶構造解析;創薬;輸送体;トランスポーター;X線結晶構造解析
      • Structure determination of histamine H1 receptor
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Tatsuro SHIMAMURA
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        アレルギー;花粉症;GPCR;結晶構造解析;ヒスタミン
      • アロステリック抗体を用いたアデノシン受容体の構造解析
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        島村 達郎
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        GPCR;アデノシン受容体;抗体;結晶構造解析;構造解析
      • Challenges for the structure determination of GPCR active conformation
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Tatsuro SHIMAMURA
        From 28 Apr. 2011, To 31 Mar. 2013, Project Closed
        X線結晶解析;受容体;GPCR;膜タンパク質;構造解析;G蛋白質共役型受容体;X線結晶構造解析
      • Elucidation of the transport mechanism of a secondary active transporter, Mhp1.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Tatsuro SHIMAMURA
        Project Closed
        X線結晶解析;輸送体;ヒダントイン;トランスポーター;交互アクセスモデル;膜タンパク質;X線結晶構造解析;交互アクセス機構;X線結晶構造解;Mhp1
      list
        Last Updated :2022/06/30

        Education

        Teaching subject(s)

        • From Apr. 2012, To Mar. 2013
          Direct observation of the protein shape and life phenomenon
          Spring, 全学共通科目

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