Basic Information

Faculty

• 医学部

Professional Memberships

• 米国核医学会
• 北米放射線学会
• 日本核医学会
• 日本医学放射線学会
• 日本癌学会

Academic Degree

• 医学博士(京都大学)

Research History

• Kyoto University Graduate School of Medicine, Associate Professor

Profile

• Profile

  I am conducting researches on molecular imaging that can capture the key characters of various diseases such as cancer. From the improvement of molecular imaging techniques and their application for disease characterization, I would like to contribute for the realization of the precision medicine and for the education of the researchers in the related fields.

Language of Instruction

• English
• Japanese

ID,URL

• ORCID ID

  0000-0001-7801-9316

• J-Global ID

  200901071957649192

researchmap URL

• https://researchmap.jp/read0046836

Research

Research Topics, Overview of the research

• Research Topics

  Research on cancer molecular imaging with PET/SPECT　and rsearch on the advanced medical imaging focusing on magnetic resonance imaging.

• Overview of the research

  I have performed basic and clinical researches of nuclear imaging and targeted radionuclide therapy using radiolabeled molecular probes targeting antigens, receptors and metabolism related to various diseases such as cancer. From the basic researches combining molecular probes and disease models and clinical PET/SPECT researches using radiolabeled molecular probes, I would like to establish the bases of pathophysiological molecular imaging methods and to collect evidences of their clinical usefulness. In addition, by combining the up-to-date AI technology, I would conduct researched on the establishment of advanced medical imaging focusing magnetic resonance imaging.

Research Interests

• Magnetic Resonance Imaging
• Medical Imaging
• Molecular Imaging
• 腫瘍核医学

Research Areas

• Life sciences, Radiology

Papers

• g-factorの分布に基づく空間的に不均一なノイズを低減する深層学習再構成法の基本性能評価

  沼元 瞳; 藤本 晃司; 伏見 育崇; 市之瀬 伸保; 南部 成仁; 佐賀 恒夫; 中本 裕士

  日本放射線技術学会総会学術大会予稿集, Mar. 2021

  
• B1マッピングを用いたMP2RAGEによるT1値計測の精度改善の試み

  沼元 瞳; 藤本 晃司; 三宅 可奈江; 伏見 育崇; 南部 成仁; 佐賀 恒夫; 中本 裕士

  日本放射線技術学会総会学術大会予稿集, Mar. 2021

  
• Development of a novel Indium-111 radiolabeled mogamulizumab targeting CCR4 for imaging adult T-cell leukemia/lymphoma in vivo.

  Yoichi Shimizu; Sho Koyasu; Mari Suzukida; Kiyotaka Izumi; Eitaro Kidera; Takero Shindo; Tsuneo Saga; Masahiro Ono; Akifumi Takaori-Kondo; Yuji Nakamoto

  Annals of nuclear medicine, 16 Jan. 2022

  
• Ga-68標識薬剤の安定供給に向けたサイクロトロンliquid target systemによるGa-68製造法の検討

  志水 陽一; 小林 敬三; 熊野 充繁; 岡村 明彦; 石守 崇好; 佐賀 恒夫; 中本 裕士

  核医学, 2021

  
• Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors

  Yoichi Shimizu; Yukihiro Nakai; Hiroyuki Watanabe; Shimpei Iikuni; Masahiro Ono; Hideo Saji; Yuji Kuge; Tsuneo Saga; Yuji Nakamoto

  EJNMMI Research, Dec. 2021, Peer-reviewed

  
• First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas

  Hiroyuki Fujimoto; Naotaka Fujita; Keita Hamamatsu; Takaaki Murakami; Yuji Nakamoto; Tsuneo Saga; Takayoshi Ishimori; Yoichi Shimizu; Hiroyuki Watanabe; Kohei Sano; Norio Harada; Hiroshi Nakamura; Kentaro Toyoda; Hiroyuki Kimura; Shunsaku Nakagawa; Mitsuharu Hirai; Atsushi Murakami; Masahiro Ono; Kaori Togashi; Hideo Saji; Nobuya Inagaki

  Frontiers in Endocrinology, 19 Aug. 2021

  
• B1マッピングを用いたMP2RAGEによるT1値計測の精度改善の試み

  沼元 瞳; 藤本 晃司; 三宅 可奈江; 伏見 育崇; 南部 成仁; 佐賀 恒夫; 中本 裕士

  日本放射線技術学会総会学術大会予稿集, Mar. 2021

  
• Diagnostic performance of 68Ga-DOTATOC PET/CT in tumor-induced osteomalacia

  Ayako Kato; Yuji Nakamoto; Takayoshi Ishimori; Nobuyuki Hayakawa; Masashi Ueda; Takashi Temma; Kohei Sano; Yoichi Shimizu; Tsuneo Saga; Kaori Togashi

  Annals of Nuclear Medicine, Mar. 2021, Peer-reviewed

  
• Clinical value of PET/CT with carbon-11 4DST in the evaluation of malignant and benign lung tumors

  Ryuichi Nishii; Tsuneo Saga; Hitomi Sudo; Takashi Togawa; Junpei Kuyama; Toshiaki Tani; Takamasa Maeda; Masato Kobayashi; Toshihiko Iizasa; Masato Shingyoji; Makiko Itami; Kazunori Kawamura; Hiroki Hashimoto; Kana Yamazaki; Kentaro Tamura; Tatsuya Higashi

  Annals of Nuclear Medicine, Feb. 2021, Peer-reviewed

  
• Qualitative and Quantitative Assessment of Nonlocal Means Reconstruction Algorithm in a Flexible PET Scanner

  Masao Watanabe; Yuji Nakamoto; Ryusuke Nakamoto; Takayoshi Ishimori; Tsuneo Saga; Kaori Togashi

  American Journal of Roentgenology, Feb. 2021, Peer-reviewed

  
• 粘膜悪性黒色腫におけるFDG PET/CTの検出能と予後予測能

  北口 耕輔; 中本 裕士; 野橋 智美; 子安 翔; 三宅 可奈江; 石守 崇好; 佐賀 恒夫

  核医学, Oct. 2020

  
• FDG PET/CTによる乳房病変検出における仰臥位と腹臥位の比較

  弓削 瞬介; 三宅 可奈江; 片岡 正子; 大野 和子; 石守 崇好; 佐賀 恒夫; 中本 裕士; 川瀬 滋人; 戸井 雅和

  核医学, Oct. 2020

  
• Deep Learning-based Noise Reduction for Fast Volume Diffusion Tensor Imaging: Assessing the Noise Reduction Effect and Reliability of Diffusion Metrics.

  Hajime Sagawa; Yasutaka Fushimi; Satoshi Nakajima; Koji Fujimoto; Kanae Kawai Miyake; Hitomi Numamoto; Koji Koizumi; Masahito Nambu; Hiroharu Kataoka; Yuji Nakamoto; Tsuneo Saga

  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 18 Sep. 2020

  
• Performance Evaluation of a Newly Developed MR-Compatible Mobile PET Scanner with Two Detector Layouts

  Masao Watanabe; Yuji Nakamoto; Ryusuke Nakamoto; Takayoshi Ishimori; Tsuneo Saga; Kaori Togashi

  Molecular Imaging and Biology, Apr. 2020, Peer-reviewed

  
• Radiolabeled Human Monoclonal Antibody 067-213 has the Potential for Noninvasive Quantification of CD73 Expression.

  Hitomi Sudo; Atsushi B Tsuji; Aya Sugyo; Gene Kurosawa; Yoshikazu Kurosawa; David Alexander; Hiroyuki Tsuda; Tsuneo Saga; Tatsuya Higashi

  International journal of molecular sciences, 26 Mar. 2020, Peer-reviewed

  
• Prognostic Value of Quantitative Parameters of 18F-FDG PET/CT for Patients With Angiosarcoma

  Ayako Kato; Yuji Nakamoto; Takayoshi Ishimori; Tsuneo Saga; Kaori Togashi

  American Journal of Roentgenology, Mar. 2020, Peer-reviewed

  
• Predominance and homogeneity patterns of physiological FDG accumulation in thoracic and lumbar vertebrae: suspected mechanism of “bone pseudometastasis” on FDG-PET in Japanese patients with esophageal cancer

  Chio Okuyama; Tatsuya Higashi; Ryusuke Nakamoto; Koichi Ishizu; Masaaki Takahashi; Kuninori Kusano; Shinya Kagawa; Tsuneo Saga; Hiroshi Yamauchi

  Annals of Nuclear Medicine, Mar. 2020, Peer-reviewed

  
• IDH変異膠芽腫において14C酢酸集積は増加する 11C酢酸PETへの基礎的検討

  子安 翔; 志水 陽一; 佐賀 恒夫; 中本 裕士; 富樫 かおり; 原田 浩

  Japanese Journal of Diagnostic Imaging, Jan. 2020

  
• Increased 14C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with 11C-acetate PET imaging.

  Sho Koyasu; Yoichi Shimizu; Akiyo Morinibu; Tsuneo Saga; Yuji Nakamoto; Kaori Togashi; Hiroshi Harada

  Journal of neuro-oncology, Dec. 2019, Peer-reviewed

  
• Prognostic utility of FDG PET/CT in advanced ovarian, fallopian and primary peritoneal high-grade serous cancer patients before and after neoadjuvant chemotherapy.

  Watanabe M; Nakamoto Y; Ishimori T; Saga T; Kido A; Hamanishi J; Hamanaka Y; Togashi K

  Annals of nuclear medicine, Nov. 2019, Peer-reviewed

  
• Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and ¹⁸F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma.

  Imaizumi A; Obata T; Kershaw J; Tachibana Y; Inubushi M; Koizumi M; Yoshikawa K; Zhang MR; Tanimoto K; Harada R; Uno T; Saga T

  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, Sep. 2019, Peer-reviewed

  
• Therapeutic efficacy evaluation of radioimmunotherapy with 90 Y-labeled anti-podoplanin antibody NZ-12 for mesothelioma.

  Sudo H; Tsuji AB; Sugyo A; Saga T; Kaneko MK; Kato Y; Higashi T

  Cancer Sci., May 2019, Peer-reviewed

  
• Anti‑tissue factor antibody‑mediated immuno‑SPECT imaging of tissue factor expression in mouse models of pancreatic cancer.

  Aya Sugyo; Winn Aung; Atsushi B Tsuji; Hitomi Sudo; Hiroki Takashima; Masahiro Yasunaga; Yasuhiro Matsumura; Tsuneo Saga; Tatsuya Higashi

  Oncology reports, Apr. 2019, Peer-reviewed

  
• Initial evaluation of PET/CT with 18 F-FSU-880 targeting prostate-specific membrane antigen in prostate cancer patients.

  Saga T; Nakamoto Y; Ishimori T; Inoue T; Shimizu Y; Kimura H; Akamatsu S; Goto T; Watanabe H; Kitaguchi K; Watanabe M; Ono M; Saji H; Ogawa O; Togashi K

  Cancer Sci., Feb. 2019, Peer-reviewed

  
• 線維形成性小円形細胞腫瘍に対するFDG PET/CTの検討

  北口 耕輔; 中本 裕士; 加藤 彩子; 渡部 正雄; 木寺 英太郎; 尾谷 知亮; 弓削 瞬介; 子安 翔; 三宅 可奈江; 石守 崇好; 佐賀 恒夫; 富樫 かおり

  核医学, 2019

  
• Direct comparison of 2 amino[3 11C]isobutyric acid and 2 amino[11C]methyl isobutyric acid uptake in eight lung cancer xenograft models.

  Sudo H; Tsuji AB; Sugyo A; Okada M; Kato K; Zhang MR; Saga T; Higashi T

  Int J Oncol., Dec. 2018, Peer-reviewed

  
• Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide.

  Tomomi Nobashi; Tsuneo Saga; Yuji Nakamoto; Yoichi Shimizu; Sho Koyasu; Takayoshi Ishimori; Masao Watanabe; Hiroyuki Kimura; Kaori Togashi

  Endocrine regulations, 01 Oct. 2018, Peer-reviewed

  
• Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with 90Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer.

  Sugyo A; Tsuji AB; Sudo H; Koizumi M; Ukai Y; Kurosawa G; Kurosawa Y; Saga T; Higashi T

  Int J Mol Sci., Sep. 2018, Peer-reviewed

  
• Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia

  Iwao Kanno; Chie Seki; Hiroyuki Takuwa; Zhao-Hui Jin; Didier Boturyn; Pascal Dumy; Takako Furukawa; Tsuneo Saga; Hiroshi Ito; Kazuto Masamoto

  Journal of Cerebral Blood Flow and Metabolism, 01 Apr. 2018, Peer-reviewed

  
• Do TSH, FT3, and FT4 Impact BAT Visualization of Clinical FDG-PET/CT Images?

  Ryuichi Nishii; Shigeki Nagamachi; Youichi Mizutani; Tamasa Terada; Syogo Kiyohara; Hideyuki Wakamatsu; Seigo Fujita; Tatsuya Higashi; Keiichiro Yoshinaga; Tsuneo Saga; Toshinori Hirai

  Contrast media & molecular imaging, 2018

  
• Do TSH, FT3, and FT4 Impact BAT Visualization of Clinical FDG-PET/CT Images?

  Ryuichi Nishii; Shigeki Nagamachi; Youichi Mizutani; Tamasa Terada; Syogo Kiyohara; Hideyuki Wakamatsu; Seigo Fujita; Tatsuya Higashi; Keiichiro Yoshinaga; Tsuneo Saga; Toshinori Hirai

  Contrast media & molecular imaging, 2018

  
• Effects of diffusion time on non-Gaussian diffusion and intravoxel incoherent motion (IVIM) MRI parameters in breast cancer and hepatocellular carcinoma xenograft models.

  Mami Iima; Tomomi Nobashi; Hirohiko Imai; Sho Koyasu; Tsuneo Saga; Yuji Nakamoto; Masako Kataoka; Akira Yamamoto; Tetsuya Matsuda; Kaori Togashi

  Acta radiologica open, Jan. 2018, Peer-reviewed

  
• Combined treatment of pancreatic cancer xenograft with Y-90-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor

  Winn Aung; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Yoshinori Ukai; Katsushi Kouda; Yoshikazu Kurosawa; Takako Furukawa; Tsuneo Saga; Tatsuya Higashi

  WORLD JOURNAL OF GASTROENTEROLOGY, Nov. 2017, Peer-reviewed

  
• Synthesis and evaluation of C-11-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression

  Hiroyuki Tateishi; Atsushi B. Tsuji; Koichi Kato; Hitomi Sudo; Aya Sugyo; Takashi Hanakawa; Ming-Rong Zhang; Tsuneo Saga; Yasushi Arano; Tatsuya Higashi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Nov. 2017, Peer-reviewed

  
• Cu-64-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts

  Yukie Yoshii; Mitsuyoshi Yoshimoto; Hiroki Matsumoto; Takako Furukawa; Ming-Rong Zhang; Masayuki Inubushi; Atsushi B. Tsuji; Yasuhisa Fujibayashi; Tatsuya Higashi; Tsuneo Saga

  ONCOTARGET, Oct. 2017, Peer-reviewed

  
• Development of Antibody-Drug Conjugates Using DDS and Molecular Imaging.

  Masahiro Yasunaga; Shino Manabe; Atsushi Tsuji; Masaru Furuta; Koretsugu Ogata; Yoshikatsu Koga; Tsuneo Saga; Yasuhiro Matsumura

  Bioengineering (Basel, Switzerland), 17 Sep. 2017, Peer-reviewed

  
• 細胞追跡イメージングのリソースとしてのhNISトランスジェニックマウスの開発

  犬伏 正幸; 道川 祐市; 鬼頭 靖司; 徐 華; 三尾 桂子; 竹内 康人; 村井 知佳; 金 永男; 辻 厚至; 長谷川 純崇; 曽川 千鶴; 数藤 由美子; 塚本 智史; 北川 善政; 佐賀 恒夫

  核医学, Sep. 2017

  
• Molecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model

  Hiroki Takashima; Atsushi B. Tsuji; Tsuneo Saga; Masahiro Yasunaga; Yoshikatsu Koga; Jun-ichiro Kuroda; Shigetoshi Yano; Jun-ichi Kuratsu; Yasuhiro Matsumura

  SCIENTIFIC REPORTS, Sep. 2017, Peer-reviewed

  
• Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation

  Daisuke Kokuryo; Ichio Aoki; Eiji Yuba; Kenji Kono; Sadahito Aoshima; Jeff Kershaw; Tsuneo Saga

  TRANSLATIONAL RESEARCH, Jul. 2017, Peer-reviewed

  
• MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach

  J. A. Wells; D. L. Thomas; T. Saga; J. Kershaw; I. Aoki

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Jun. 2017, Peer-reviewed

  
• Detection of tumor hypoxic region using pH-activatable nanoparticles containing manganese contrast agent

  KOKURYO Daisuke; MI Peng; CABRAL Horacio; SAGA Tsuneo; AOKI Ichio; NISHIYAMA Nobuhiro; KATAOKA Kazunori

  Proceedings of International Society for Magnetic Resonance in Medicine 25th Annual Meeting and Exibition, Apr. 2017, Peer-reviewed

  
• Cu-67-Radiolabeling of a multimeric RGD peptide for alpha(v)beta(3) integrin-targeted radionuclide therapy: stability, therapeutic efficacy, and safety studies in mice

  Zhao-Hui Jin; Takako Furukawa; Tomoyuki Ohya; Melissa Degardin; Aya Sugyo; Atsushi B. Tsuji; Yasuhisa Fujibayashi; Ming-Rong Zhang; Tatsuya Higashi; Didier Boturyn; Pascal Dumy; Tsuneo Saga

  NUCLEAR MEDICINE COMMUNICATIONS, Apr. 2017, Peer-reviewed

  
• Uptake of In-111-labeled fully human monoclonal antibody TSP-A18 reflects transferrin receptor expression in normal organs and tissues of mice

  Aya Sugyo; Atsushi B. Tsuji; Hitomi Sudo; Fumiko Nomura; Hirokazu Satoh; Mitsuru Koizumi; Gene Kurosawa; Yoshikazu Kurosawa; Tsuneo Saga

  ONCOLOGY REPORTS, Mar. 2017, Peer-reviewed

  
• SPECT/PET/CT二核種同時測定を用いた腫瘍内血管分布・低酸素領域イメージング法の開発

  吉井幸恵; 足立直也; 吉本光喜; 松本博樹; 古川高子; 張明栄; 犬伏正幸; 藤林靖久; 佐賀恒夫

  JSMI Report, 2017, Peer-reviewed

  
• Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli

  Jack A. Wells; Sayaka Shibata; Akihiko Fujikawa; Masayasu Takahashi; Tsuneo Saga; Ichio Aoki

  SCIENTIFIC REPORTS, Jan. 2017, Peer-reviewed

  
• Clinical, Morphologic, and Pathologic Features Associated With Increased FDG Uptake in Schwannoma

  Kanae K. Miyake; Yuji Nakamoto; Tatsuki R. Kataoka; Chiyuki Ueshima; Tatsuya Higashi; Tsuyoshi Terashima; Koya Nakatani; Tsuneo Saga; Shunsuke Minami; Kaori Togashi

  AMERICAN JOURNAL OF ROENTGENOLOGY, Dec. 2016, Peer-reviewed

  
• The predictive value of preoperative F-18-fluorodeoxyglucose PET for postoperative recurrence in patients with localized primary gastrointestinal stromal tumour

  Kanae Kawai Miyake; Yuji Nakamoto; Yoshiki Mikami; Shiro Tanaka; Tatsuya Higashi; Eiji Tadamura; Tsuneo Saga; Shunsuke Minami; Kaori Togashi

  EUROPEAN RADIOLOGY, Dec. 2016, Peer-reviewed

  
• alpha(V)beta(3) Integrin-Targeted Radionuclide Therapy with Cu-64-cyclam-RAFT-c(-RGDfK-)(4)

  Zhao-Hui Jin; Takako Furukawa; Melissa Degardin; Aya Sugyo; Atsushi B. Tsuji; Tomoteru Yamasaki; Kazunori Kawamura; Yasuhisa Fujibayashi; Ming-Rong Zhang; Didier Boturyn; Pascal Dumy; Tsuneo Saga

  MOLECULAR CANCER THERAPEUTICS, Sep. 2016, Peer-reviewed, Invited

  
• Functional evaluation of rat hearts transplanted after preservation in a high-pressure gaseous mixture of carbon monoxide and oxygen.

  Naoyuki Hatayama; Masayuki Inubushi; Munekazu Naito; Shuichi Hirai; Yong-Nan Jin; Atsushi B Tsuji; Kunihiro Seki; Masahiro Itoh; Tsuneo Saga; Xiao-Kang Li

  Scientific reports, 26 Aug. 2016, Peer-reviewed

  
• A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

  Peng Mi; Daisuke Kokuryo; Horacio Cabral; Hailiang Wu; Yasuko Terada; Tsuneo Saga; Ichio Aoki; Nobuhiro Nishiyama; Kazunori Kataoka

  Nature Nanotechnology, Aug. 2016, Peer-reviewed

  
• Radioimmunotherapy of pancreatic cancer xenografts in nude mice using Y-90-labeled anti-alpha(6)beta(4) integrin antibody

  Winn Aung; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Yoshinori Ukai; Katsushi Kouda; Yoshikazu Kurosawa; Takako Furukawa; Tsuneo Saga

  ONCOTARGET, Jun. 2016, Peer-reviewed

  
• Cu-64-ATSM therapy targets regions with activated DNA repair and enrichment of CD133(+) cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite

  Yukie Yoshii; Takako Furukawa; Hiroki Matsumoto; Mitsuyoshi Yoshimoto; Yasushi Kiyono; Ming-Rong Zhang; Yasuhisa Fujibayashi; Tsuneo Saga

  CANCER LETTERS, Jun. 2016, Peer-reviewed

  
• Prognostic value of PET/CT with F-18-fluoroazomycin arabinoside for patients with head and neck squamous cell carcinomas receiving chemoradiotherapy

  Tsuneo Saga; Masayuki Inubushi; Mitsuru Koizumi; Kyosan Yoshikawa; Ming-Rong Zhang; Takayuki Obata; Katsuyuki Tanimoto; Rintaro Harada; Takashi Uno; Yasuhisa Fujibayashi

  ANNALS OF NUCLEAR MEDICINE, Apr. 2016, Peer-reviewed

  
• Regorafenib as a potential adjuvant chemotherapy agent in disseminated small colon cancer: Drug selection outcome of a novel screening system using nanoimprinting 3-dimensional culture with HCT116-RFP cells

  Yukie Yoshii; Takako Furukawa; Hironori Aoyama; Naoya Adachi; Ming-Rong Zhang; Hidekatsu Wakizaka; Yasuhisa Fujibayashi; Tsuneo Saga

  INTERNATIONAL JOURNAL OF ONCOLOGY, Apr. 2016, Peer-reviewed

  
• Docosahexaenoic Acid Sensitizes Leukemia Lymphocytes to Barasertib and Everolimus by ROS-dependent Mechanism Without Affecting the Level of ROS and Viability of Normal Lymphocytes

  Zhivko Zhelev; Donika Ivanova; Desislava Lazarova; Ichio Aoki; Rumiana Bakalova; Tsuneo Saga

  ANTICANCER RESEARCH, Apr. 2016, Peer-reviewed

  
• Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein

  Hitomi Sudo; Atsushi B. Tsuji; Aya Sugyo; Hiroyuki Takuwa; Kazuto Masamoto; Yutaka Tomita; Norihiro Suzuki; Takeshi Imamura; Mitsuru Koizumi; Tsuneo Saga

  INTERNATIONAL JOURNAL OF ONCOLOGY, Feb. 2016, Peer-reviewed

  
• Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model.

  Aung W; Tsuji AB; Sudo H; Sugyo A; Furukawa T; Ukai Y; Kurosawa Y; Saga T

  Molecular Imaging, 29 Jan. 2016, Peer-reviewed

  
• Passive and electro-assisted delivery of hydrogel nanoparticles in solid tumors, visualized by optical and magnetic resonance imaging in vivo

  Rumiana Bakalova; Biliana Nikolova; Shuhei Murayama; Severina Atanasova; Zhivko Zhelev; Ichio Aoki; Masaru Kato; Iana Tsoneva; Tsuneo Saga

  ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Jan. 2016, Peer-reviewed

  
• In vivo simultaneous imaging of vascular pool and hypoxia with a HT-29 tumor model: The application of dual-isotope SPECT/PET/CT.

  Adachi N; Yoshii Y; Furukawa T; Yoshimoto M; Takeuchi Y; Inubushi M; Wakizaka H; Zhang MR; Tsuji AB; Takahashi M; Fujibayashi Y; Saga T

  Int J Sci: Basic Appl Res., Jan. 2016, Peer-reviewed

  
• Immunotargeting of Integrin alpha(6)beta(4) for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model

  Winn Aung; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Takako Furukawa; Yoshinori Ukai; Yoshikazu Kurosawa; Tsuneo Saga

  MOLECULAR IMAGING, Jan. 2016, Peer-reviewed

  
• Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

  Ichio Aoki; Misao Yoneyama; Jun Hirose; Yuzuru Minemoto; Takayoshi Koyama; Daisuke Kokuryo; Rumiana Bakalova; Shuhei Murayama; Tsuneo Saga; Sadahito Aoshima; Yukihito Ishizaka; Kenji Kono

  TRANSLATIONAL RESEARCH, Dec. 2015, Peer-reviewed

  
• Magnetic Resonance Imaging of Mitochondrial Dysfunction and Metabolic Activity, Accompanied by Overproduction of Superoxide

  Rumiana Bakalova; Ekaterina Georgieva; Donika Ivanova; Zhivko Zhelev; Ichio Aoki; Tsuneo Saga

  ACS CHEMICAL NEUROSCIENCE, Dec. 2015, Peer-reviewed

  
• gamma-PARCEL: Control of Molecular Release Using gamma-Rays

  Shuhei Murayama; Jun-ichiro Jo; Kazutaka Arai; Fumihiko Nishikido; Rumiana Bakalova; Taiga Yamaya; Tsuneo Saga; Masaru Kato; Ichio Aoki

  ANALYTICAL CHEMISTRY, Dec. 2015, Peer-reviewed

  
• 2-Deoxy-D-glucose Sensitizes Cancer Cells to Barasertib and Everolimus by ROS-independent Mechanism(s)

  Zhivko Zhelev; Donika Ivanova; Ichio Aoki; Tsuneo Saga; Rumiana Bakalova

  ANTICANCER RESEARCH, Dec. 2015, Peer-reviewed

  
• Preclinical evaluation of 2-amino-2-[C-11]methyl-butanoic acid as a potential tumor-imaging agent in a mouse model

  Chie Suzuki; Atsushi B. Tsuji; Koichi Kato; Hitomi Sudo; Ming-Rong Zhang; Tsuneo Saga

  NUCLEAR MEDICINE COMMUNICATIONS, Nov. 2015, Peer-reviewed

  
• Development of the Fibronectin Mimetic Peptide KSSPHSRN(SG)(5)RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker alpha(5)beta(1) Integrin

  Zhao-Hui Jin; Takako Furukawa; Katsushi Kumata; Lin Xie; Joji Yui; Hidekatsu Wakizaka; Yasuhisa Fujibayashi; Ming-Rong Zhang; Tsuneo Saga

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2015, Peer-reviewed

  
• Prognostic value of F-18-fluoroazomycin arabinoside PET/CT in patients with advanced non-small-cell lung cancer

  Tsuneo Saga; Masayuki Inubushi; Mitsuru Koizumi; Kyosan Yoshikawa; Ming-Rong Zhang; Katsuyuki Tanimoto; Atsushi Horiike; Noriko Yanagitani; Fumiyoshi Ohyanagi; Makoto Nishio

  CANCER SCIENCE, Nov. 2015, Peer-reviewed

  
• Immuno-PET Imaging of HER3 in a Model in which HER3 Signaling Plays a Critical Role

  Qinghua Yuan; Takako Furukawa; Takahiro Tashiro; Kouki Okita; Zhao-Hui Jin; Winn Aung; Aya Sugyo; Kotaro Nagatsu; Hiroko Endo; Atsushi B. Tsuji; Ming-Rong Zhang; Takashi Masuko; Masahiro Inoue; Yasuhisa Fujibayashi; Tsuneo Saga

  PLOS ONE, Nov. 2015, Peer-reviewed

  
• Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer

  Yutaka Miura; Atsushi B. Tsuji; Aya Sugyo; Hitomi Sudo; Ichio Aok; Masayuki Inubushi; Masakazu Yashiro; Kosei Hirakawa; Horacio Cabral; Nobuhiro Nishiyama; Tsuneo Saga; Kazunori Kataoka

  ACS BIOMATERIALS SCIENCE & ENGINEERING, Nov. 2015, Peer-reviewed

  
• Transcriptomic Signatures of Auger Electron Radioimmunotherapy Using Nuclear Targeting In-111-Trastuzumab for Potential Combination Therapies

  Huizi Keiko Li; Yukie Morokoshi; Kazuhiro Daino; Takako Furukawa; Tadashi Kamada; Tsuneo Saga; Sumitaka Hasegawa

  CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, Oct. 2015, Peer-reviewed

  
• A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-alpha-D-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone]

  Takako Furukawa; Qinghua Yuan; Zhao-Hui Jin; Winn Aung; Yukie Yoshii; Sumitaka Hasegawa; Hiroko Endo; Masahiro Inoue; Ming-Rong Zhang; Yasuhisa Fujibayashi; Tsuneo Saga

  ONCOLOGY REPORTS, Sep. 2015, Peer-reviewed

  
• Evaluation of nanoparticle accumulation and treatment efficacy for a combined heavy-ion-beam irradiation and drug-delivery tumor therapy

  Kokuryo Daisuke; Yuba Eiji; Kono Kenji; Saga Tsuneo; Aoki Ichio

  Proceedings of International Society for Magnetic Resonance in Medicine 23 th Annual Meeting and Exibition, Jun. 2015, Peer-reviewed

  
• Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET

  Kenta Miwa; Masayuki Inubushi; Yasuto Takeuchi; Tetsuro Katafuchi; Mitsuru Koizumi; Tsuneo Saga; Masayuki Sasaki

  ANNALS OF NUCLEAR MEDICINE, Jun. 2015, Peer-reviewed

  
• Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas

  Wataru Kawamura; Yutaka Miura; Daisuke Kokuryo; Kazuko Toh; Naoki Yamada; Takahiro Nomoto; Yu Matsumoto; Daiki Sueyoshi; Xueying Liu; Ichio Aoki; Mitsunobu R. Kano; Nobuhiro Nishiyama; Tsuneo Saga; Akihiro Kishimura; Kazunori Kataoka

  SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, Jun. 2015, Peer-reviewed

  
• Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET

  Miwa Kenta; Inubushi Masayuki; Takeuchi Yasuto; Katafuchi Tetsuro; Koizumi Mitsuru; Saga Tsuneo; Sasaki Masayuki

  JOURNAL OF NUCLEAR MEDICINE, 01 May 2015, Peer-reviewed

  
• High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment

  Yukie Yoshii; Takako Furukawa; Atsuo Waki; Hiroaki Okuyama; Masahiro Inoue; Manabu Itoh; Ming-Rong Zhang; Hidekatsu Wakizaka; Chizuru Sogawa; Yasushi Kiyono; Hiroshi Yoshii; Yasuhisa Fujibayashi; Tsuneo Saga

  BIOMATERIALS, May 2015, Peer-reviewed

  
• In vivo F-18-fluorodeoxyglucose-positron emission tomography/computed tomography imaging of pancreatic tumors in a transgenic rat model carrying the human KRAS(G12V) oncogene

  Koji Shibata; Katsumi Fukamachi; Atsushi Tsuji; Tsuneo Saga; Mitsuru Futakuchi; Masato Nagino; Hiroyuki Tsuda; Masumi Suzui

  ONCOLOGY LETTERS, May 2015, Peer-reviewed

  
• Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino[3-C-11]isobutyric acid

  Atsushi B. Tsuji; Aya Sugyo; Hitomi Sudo; Chie Suzuki; Hedekatsu Wakizaka; Ming-Rong Zhang; Koichi Kato; Tsuneo Saga

  ONCOLOGY REPORTS, May 2015, Peer-reviewed

  
• Evaluation of Efficacy of Radioimmunotherapy with Y-90- Labeled Fully Human Anti-Transferrin Receptor Monoclonal Antibody in Pancreatic Cancer Mouse Models

  Aya Sugyo; Atsushi B. Tsuji; Hitomi Sudo; Maki Okada; Mitsuru Koizumi; Hirokazu Satoh; Gene Kurosawa; Yoshikazu Kurosawa; Tsuneo Saga

  PLOS ONE, Apr. 2015, Peer-reviewed

  
• Preclinical evaluation of Zr-89-labeled human antitransferrin receptor monoclonal antibody as a PET probe using a pancreatic cancer mouse model

  Aya Sugyo; Atsushi B. Tsuji; Hitomi Sudo; Kotaro Nagatsu; Mitsuru Koizumi; Yoshinori Ukai; Gene Kurosawa; Ming-Rong Zhang; Yoshikazu Kurosawa; Tsuneo Saga

  NUCLEAR MEDICINE COMMUNICATIONS, Mar. 2015, Peer-reviewed

  
• Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging

  Sumitaka Hasegawa; Yukie Morokoshi; Atsushi B. Tsuji; Toshiaki Kokubo; Ichio Aoki; Takako Furukawa; Ming-Rong Zhang; Tsuneo Saga

  MOLECULAR ONCOLOGY, Mar. 2015, Peer-reviewed

  
• Inhibition of radical reactions for an improved potassium tert-butoxide-promoted C-11-methylation strategy for the synthesis of alpha-C-11-methyl amino acids

  Chie Suzuki; Koichi Kato; Atsushi B. Tsuji; Ming-Rong Zhang; Yasushi Arano; Tsuneo Saga

  JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Mar. 2015, Peer-reviewed

  
• Lymph node mapping using quantum dot-labeled polymersomes

  Rumiana Bakalova; Zhivko Zhelev; Biliana Nikolova; Shuhei. Murayama; Iana Tsoneva; Ichio. Aoki; Tsuneo. Saga

  Gen. Physiol. Biophys, 2015, Peer-reviewed

  
• Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI

  Daisuke Kokuryo; Seiji Nakashima; Fuminori Ozaki; Eiji Yuba; Kai-Hsiang Chuang; Sadahito Aoshima; Yukihito Ishizaka; Tsuneo Saga; Kenji Kono; Ichio Aoki

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Jan. 2015, Peer-reviewed

  
• Clinical utility and limitations of FDG PET in detecting recurrent hepatocellular carcinoma in postoperative patients

  Nobuyuki Hayakawa; Yuji Nakamoto; Koya Nakatani; Etsuro Hatano; Satoru Seo; Tatsuya Higashi; Tsuneo Saga; Shinji Uemoto; Kaori Togashi

  INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Dec. 2014, Peer-reviewed

  
• Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions

  Yasuto Takeuchi; Masayuki Inubushi; Yong-Nan Jin; Chika Murai; Atsushi B. Tsuji; Hironobu Hata; Yoshimasa Kitagawa; Tsuneo Saga

  ANNALS OF NUCLEAR MEDICINE, Dec. 2014, Peer-reviewed

  
• Implications of cancer induced blood coagulation in cancer diagnosis and therapy

  Hisada Yohei; Yasunaga Masahiro; Hanaoka Shingo; Saijou Shinji; Sugino Takashi; Tsuji Atsushi; Saga Tsuneo; Tsumoto Kouhei; Manabe Shino; Kuroda Jun-ichiro; Kuratsu Jun-ichi; Matsumura Yasuhiro

  CANCER RESEARCH, 01 Oct. 2014, Peer-reviewed

  
• Preclinical Characterization of 5-Amino-4-Oxo-[6-C-11] Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

  Chie Suzuki; Atsushi B. Tsuji; Koichi Kato; Tatsuya Kikuchi; Hitomi Sudo; Maki Okada; Aya Sugyo; Ming-Rong Zhang; Yasushi Arano; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, Oct. 2014, Peer-reviewed

  
• Comparison of intratumoral FDG and Cu-ATSM distributions in cancer tissue originated spheroid (CTOS) xenografts, a tumor model retaining the original tumor properties

  Takako Furukawa; Qinghua Yuan; Zhao-Hui Jin; Winn Aung; Yukie Yoshii; Sumitaka Hasegawa; Hiroko Endo; Masahiro Inoue; Ming-Rong Zhang; Yasuhisa Fujibayashi; Tsuneo Saga

  NUCLEAR MEDICINE AND BIOLOGY, Sep. 2014, Peer-reviewed

  
• Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

  Chizuru Sogawa; Yasuhiro Fujiwara; Satoshi Tsukamoto; Yuka Ishida; Yukie Yoshii; Takako Furukawa; Tetsuo Kunieda; Tsuneo Saga

  REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, Jul. 2014, Peer-reviewed

  
• 64Cu-ATSMによる腫瘍内がん幹細胞ニッチを標的としたイメージング/内照射治療の展望 実用化に向けた副作用低減化法の開発

  吉井 幸恵; 松本 博樹; 吉本 光喜; 古川 高子; 諸越 幸恵; 曽川 千鶴; 張 明栄; 脇坂 秀克; 吉井 裕; 藤林 靖久; 佐賀 恒夫

  JSMI Report, May 2014

  
• 腫瘍内の低酸素遺伝子応答と低酸素PETトレーサー集積の関係

  竹内 康人; 犬伏 正幸; 村井 知佳; 秦 浩信; 北川 善政; 佐賀 恒夫

  JSMI Report, May 2014

  
• Intracerebral drug delivery treatment using a regularly-structured biodegradable gel for slow-release of gadolinium-containing nano-micelles in a glioblastoma model

  KOKURYO Daisuke; MI Peng; KURITA Tomoka; YATABE Teruyuki; CABRAL Horacio; SHIBATA Sayaka; MURAGAKI Yoshihiro; ISEKI Hiroshi; SAKAI Takamasa; CHUNG Ung-il; NISHIYAMA Nobuhiro; SAGA Tsuneo; AOKI Ichio; KATAOKA Kazunori

  Proceeding of Joint Annual Meeting of ISMRM-ESMRMB, May 2014, Peer-reviewed

  
• PET imaging and biodistribution analysis of the effects of succinylated gelatin combined with L-lysine on renal uptake and retention of Cu-64-cyclam-RAFT-c(-RGDfK-)(4) in vivo

  Zhao-Hui Jin; Takako Furukawa; Chizuru Sogawa; Michael Claron; Winn Aung; Atsushi B. Tsuji; Hidekatsu Wakizaka; Ming-Rong Zhang; Didier Boturyn; Pascal Dumy; Yasuhisa Fujibayashi; Tsuneo Saga

  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Apr. 2014, Peer-reviewed

  
• SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes) (vol 169, pg 220, 2013)

  Kokuryo Daisuke; Anraku Yasutaka; Kishimura Akihiro; Tanaka Sayaka; Kano Mitsunobu R; Kershaw Jeff; Nishiyama Nobuhiro; Saga Tsuneo; Aoki Ichio; Kataoka Kazunori

  JOURNAL OF CONTROLLED RELEASE, 28 Mar. 2014, Peer-reviewed

  
• AHNAK is highly expressed and plays a key role in cell migration and invasion in mesothelioma

  Hitomi Sudo; Atsushi B. Tsuji; Aya Sugyo; Masaaki Abe; Okio Hino; Tsuneo Saga

  INTERNATIONAL JOURNAL OF ONCOLOGY, Feb. 2014, Peer-reviewed

  
• Clinical practice guideline for dedicated breast PET

  Makoto Hosono; Tsuneo Saga; Kengo Ito; Shinichiro Kumita; Masayuki Sasaki; Michio Senda; Jun Hatazawa; Hiroshi Watanabe; Hiroshi Ito; Shinichi Kanaya; Yuichi Kimura; Hideo Saji; Seishi Jinnouchi; Hiroyoshi Fukukita; Koji Murakami; Seigo Kinuya; Junichi Yamazaki; Mayuki Uchiyama; Koichi Uno; Katsuhiko Kato; Tsuyoshi Kawano; Kazuo Kubota; Takashi Togawa; Norinari Honda; Hirotaka Maruno; Mana Yoshimura; Masami Kawamoto; Yukihiko Ozawa

  Annals of Nuclear Medicine, 2014, Peer-reviewed

  
• Controlled Administration of Penicillamine Reduces Radiation Exposure in Critical Organs during Cu-64-ATSM Internal Radiotherapy: A Novel Strategy for Liver Protection

  Yukie Yoshii; Hiroki Matsumoto; Mitsuyoshi Yoshimoto; Takako Furukawa; Yukie Morokoshi; Chizuru Sogawa; Ming-Rong Zhang; Hidekatsu Wakizaka; Hiroshi Yoshii; Yasuhisa Fujibayashi; Tsuneo Saga

  PLOS ONE, Jan. 2014, Peer-reviewed

  
• In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI)

  Satoko Hattori; Hideo Hagihara; Koji Ohira; Ichio Aoki; Tsuneo Saga; Tetsuya Suhara; Makoto Higuchi; Tsuyoshi Miyakawa

  Frontiers in Integrative Neuroscience, 11 Nov. 2013, Peer-reviewed

  
• Imaging of Superoxide Generation in the Dopaminergic Area of the Brain in Parkinson's Disease, Using Mito-TEMPO

  Zhivko Zhelev; Rumiana Bakalova; Ichio Aoki; Dessislava Lazarova; Tsuneo Saga

  ACS CHEMICAL NEUROSCIENCE, Nov. 2013, Peer-reviewed

  
• 腫瘍内の低酸素遺伝子応答と低酸素PETトレーサ集積の関係

  竹内 康人; 犬伏 正幸; 村井 知佳; 秦 浩信; 北川 善政; 佐賀 恒夫

  核医学, Sep. 2013

  
• 乳房専用PET診療ガイドライン 平成25年7月

  細野 眞; 佐賀 恒夫; 伊藤 健吾; 汲田 伸一郎; 佐々木 雅之; 千田 道雄; 畑澤 順; 渡邉 浩; 伊藤 浩; 金谷 信一; 木村 裕一; 佐治 英郎; 陣之内 正史; 福喜多 博義; 村上 康二; 絹谷 清剛; 山崎 純一; 内山 眞幸; 宇野 公一; 加藤 克彦; 川野 剛; 窪田 和雄; 戸川 貴史; 本田 憲業; 丸野 廣大; 吉村 真奈; 川本 雅美; 小澤 幸彦; 日本核医学会PET核医学委員会, 日本核医学会健保委員会

  核医学, Sep. 2013

  
• SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)

  Daisuke Kokuryo; Yasutaka Anraku; Akihiro Kishimura; Sayaka Tanaka; Mitsunobu R. Kano; Jeff Kershaw; Nobuhiro Nishiyama; Tsuneo Saga; Ichio Aoki; Kazunori Kataoka

  JOURNAL OF CONTROLLED RELEASE, Aug. 2013, Peer-reviewed

  
• Synthesis and in vitro cellular uptake of C-11-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX

  Chie Suzuki; Koichi Kato; Atsushi B. Tsuji; Tatsuya Kikuchi; Ming-Rong Zhang; Yasushi Arano; Tsuneo Saga

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2013, Peer-reviewed

  
• Molecular imaging of aquaglycero-aquaporins: Its potential for cancer characterization

  Yuriko Saito; Takako Furukawa; Takayuki Obata; Tsuneo Saga

  Biological and Pharmaceutical Bulletin, Aug. 2013, Peer-reviewed

  
• Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development.

  Noriko Takahara; Tsuneo Saga; Masayuki Inubushi; Hiroyuki Kusuhara; Chie Seki; Sumito Ito; Nobuyuki Oyama; Osamu Yokoyama; Yuichi Sugiyama; Yasuhisa Fujibayashi

  Nuclear medicine and biology, Jul. 2013, Peer-reviewed

  
• Accuracy of methionine-PET in predicting the efficacy of heavy-particle therapy on primary adenoid cystic carcinomas of the head and neck

  Sachiko Toubaru; Kyosan Yoshikawa; Seiya Ohashi; Katsuyuki Tanimoto; Azusa Hasegawa; Koji Kawaguchi; Tsuneo Saga; Tadashi Kamada

  Radiation Oncology, 13 Jun. 2013, Peer-reviewed

  
• Growth retardation and hair loss in transgenic mice overexpressing human H-ferritin gene

  Sumitaka Hasegawa; Kazutoshi Harada; Yukie Morokoshi; Satoshi Tsukamoto; Takako Furukawa; Tsuneo Saga

  TRANSGENIC RESEARCH, Jun. 2013, Peer-reviewed

  
• Manganese-Enhanced MRI Reveals Early- Phase RadiationInduced Cell Alterations In Vivo

  Shigeyoshi Saito; Sumitaka Hasegawa; Aiko Sekita; Rumiana Bakalova; Takako Furukawa; Kenya Murase; Tsuneo Saga; Ichio Aoki

  CANCER RESEARCH, Jun. 2013, Peer-reviewed

  
• Tissue Redox Activity as a Hallmark of Carcinogenesis: From Early to Terminal Stages of Cancer

  Rumiana Bakalova; Zhivko Zhelev; Ichio Aoki; Tsuneo Saga

  CLINICAL CANCER RESEARCH, May 2013, Peer-reviewed

  
• Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome

  Yukie Yoshii; Takako Furukawa; Nobuyuki Oyama; Yoko Hasegawa; Yasushi Kiyono; Ryuichi Nishii; Atsuo Waki; Atsushi B. Tsuji; Chizuru Sogawa; Hidekatsu Wakizaka; Toshimitsu Fukumura; Hiroshi Yoshii; Yasuhisa Fujibayashi; Jason S. Lewis; Tsuneo Saga

  PLOS ONE, May 2013, Peer-reviewed

  
• SPIO-loaded unilamellar polyion complex vesicles (SPIO-Cy5-PICsomes) as a high relaxivity contrast agent for tumor detection

  D. Kokuryo; Y. Anraku; A. Kishimura; M. R Kano; S. Tanaka; T. Saga; I. Aoki; K. Kataoka

  Proc. 21th ISMRM Scientific Meeting and Exhibition, Apr. 2013, Peer-reviewed

  
• Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle

  Zhivko Zhelev; Ichio Aoki; Veselina Gadjeva; Biliana Nikolova; Rumiana Bakalova; Tsuneo Saga

  EUROPEAN JOURNAL OF CANCER, Apr. 2013, Peer-reviewed

  
• Evaluation of Zr-89-Labeled Human Anti-CD147 Monoclonal Antibody as a Positron Emission Tomography Probe in a Mouse Model of Pancreatic Cancer

  Aya Sugyo; Atsushi B. Tsuji; Hitomi Sudo; Kotaro Nagatsu; Mitsuru Koizumi; Yoshinori Ukai; Gene Kurosawa; Ming-Rong Zhang; Yoshikazu Kurosawa; Tsuneo Saga

  PLOS ONE, Apr. 2013, Peer-reviewed

  
• Fluorescent imaging for assessment of the effect of combined application of electroporation and rifampicin on HaCaT cells as a new therapeutic approach for psoriasis

  Biliana Nikolova; Anelia Kostadinova; Borislav Dimitrov; Zhivko Zhelev; Rumiana Bakalova; Ichio Aoki; Tsuneo Saga; Iana Tsoneva

  Sensors (Switzerland), Mar. 2013, Peer-reviewed

  
• Therapeutic Efficacy of C-Kit-Targeted Radioimmunotherapy Using 90Y-Labeled Anti-C-Kit Antibodies in a Mouse Model of Small Cell Lung Cancer

  Chisato Yoshida; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Tatsuya Kikuchi; Mitsuru Koizumi; Yasushi Arano; Tsuneo Saga

  PLOS ONE, Mar. 2013, Peer-reviewed

  
• Preparation of polymer-based magnetic resonance imaging contrast agent to visualize therapeutic angiogenesis

  Jun-Ichiro Jo; Xue Lin; Teppei Nakahara; Ichio Aoki; Tsuneo Saga; Yasuhiko Tabata

  Tissue Engineering - Part A, 01 Jan. 2013, Peer-reviewed

  
• Predictive value of 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma.

  Masayuki Inubushi; Tsuneo Saga; Mitsuru Koizumi; Ryo Takagi; Azusa Hasegawa; Masashi Koto; Masaru Wakatuki; Takamichi Morikawa; Kyosan Yoshikawa; Katsuyuki Tanimoto; Toshimitsu Fukumura; Shigeru Yamada; Tadashi Kamada

  Annals of nuclear medicine, Jan. 2013, Peer-reviewed

  
• Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging

  Peng Mi; Horacio Cabral; Daisuke Kokuryo; Mohammad Rafi; Yasuko Terada; Ichio Aoki; Tsuneo Saga; Ishii Takehiko; Nobuhiro Nishiyama; Kazunori Kataoka

  BIOMATERIALS, Jan. 2013, Peer-reviewed

  
• Interferon-β delivery via human neural stem cell abates glial scar formation in spinal cord injury

  Yusuke Nishimura; Atsushi Natsume; Motokazu Ito; Masahito Hara; Kazuya Motomura; Ryuichi Fukuyama; Naoyuki Sumiyoshi; Ichio Aoki; Tsuneo Saga; Hong J. Lee; Toshihiko Wakabayashi; Seung U. Kim

  Cell Transplantation, 2013, Peer-reviewed

  
• C-Type Natriuretic Peptide Specifically Acts on the Pylorus and Large Intestine in Mouse Gastrointestinal Tract

  Chizuru Sogawa; Hidekatsu Wakizaka; Winn Aung; Zhao-hui Jin; Atsushi B. Tsuji; Takako Furukawa; Tetsuo Kunieda; Tsuneo Saga

  AMERICAN JOURNAL OF PATHOLOGY, Jan. 2013, Peer-reviewed

  
• Micro-positron emission tomography/contrast-enhanced computed tomography imaging of orthotopic pancreatic tumor-bearing mice using the αvβ3 integrin tracer 64Cu-labeled cyclam-RAFT-c(-RGDfK-)4

  Winn Aung; Zhao-Hui Jin; Takako Furukawa; Michael Claron; Didier Boturyn; Chizuru Sogawa; Atsushi B. Tsuji; Hidekatsu Wakizaka; Toshimitsu Fukumura; Yasuhisa Fujibayashi; Pascal Dumy; Tsuneo Saga

  Molecular Imaging, 2013, Peer-reviewed

  
• Discovery of an uncovered region in fibrin clots and its clinical significance.

  Yohei Hisada; Masahiro Yasunaga; Shingo Hanaoka; Shinji Saijou; Takashi Sugino; Atsushi Tsuji; Tsuneo Saga; Kouhei Tsumoto; Shino Manabe; Jun-ichiro Kuroda; Jun-ichi Kuratsu; Yasuhiro Matsumura

  Scientific reports, 2013, Peer-reviewed

  
• The simple preparation of polyethylene glycol-based soft nanoparticles containing dual imaging probes

  Shuhei Murayama; Jun-ichiro Jo; Yuka Shibata; Kun Liang; Tomofumi Santa; Tsuneo Saga; Ichio Aoki; Masaru Kato

  JOURNAL OF MATERIALS CHEMISTRY B, 2013, Peer-reviewed

  
• Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe Cu-64-cyclam-RAFT-c(-RGDfK-)(4)

  Zhao-Hui Jin; Takako Furukawa; Michael Claron; Didier Boturyn; Jean-Luc Coll; Toshimitsu Fukumura; Yasuhisa Fujibayashi; Pascal Dumy; Tsuneo Saga

  ANGIOGENESIS, Dec. 2012, Peer-reviewed

  
• Guidelines for clinical use of FDG PET, PET/CT 2012

  細野 眞; 佐賀 恒夫; 伊藤 健吾; 汲田 伸一郎; 佐々木 雅之; 千田 道雄; 畑澤 順; 渡邉 浩; 伊藤 浩; 金谷 信一; 木村 裕一; 佐治 英郎; 陣之内 正史; 福喜多 博義; 村上 康二; 絹谷 清剛; 山崎 純一; 内山 眞幸; 宇野 公一; 加藤 克彦; 川野 剛; 日下部 きよ子; 窪田 和雄; 戸川 貴史; 本田 憲業; 丸野 廣大; 吉村 真奈; 宍戸 文男; 井上 登美夫; 福田 寛; 中村 佳代子

  Jpn J Nucl Med (Kaku Igaku), 30 Nov. 2012

  
• H-ferritin overexpression promotes radiation-induced leukemia/lymphoma in mice

  Sumitaka Hasegawa; Yukie Morokoshi; Hiroaki Kanda; Satoshi Tsukamoto; Jian Zheng; Atsushi B. Tsuji; Takako Furukawa; Shizuko Kakinuma; Yoshiya Shimada; Tsuneo Saga

  CARCINOGENESIS, Nov. 2012, Peer-reviewed

  
• Basic Studies on Radioimmunotargeting of CD133-Positive HCT116 Cancer Stem Cells

  Zhao-Hui Jin; Chizuru Sogawa; Takako Furukawa; Yuriko Saito; Winn Aung; Yasuhisa Fujibayashi; Tsuneo Saga

  MOLECULAR IMAGING, Nov. 2012, Peer-reviewed

  
• Comparison of 2-amino-[3-C-11]isobutyric acid and 2-deoxy-2-[F-18]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation

  Atsushi B. Tsuji; Koichi Kato; Aya Sugyo; Maki Okada; Hitomi Sudo; Chisato Yoshida; Hidekatsu Wakizaka; Ming-Rong Zhang; Tsuneo Saga

  NUCLEAR MEDICINE COMMUNICATIONS, Oct. 2012, Peer-reviewed

  
• Na+/I-共輸送タンパクを用いた低酸素応答の分子遺伝子イメージング

  竹内 康人; 犬伏 正幸; 村井 知佳; 秦 浩信; 北川 善政; 佐賀 恒夫

  核医学, Aug. 2012

  
• マウス自然発生肝転移モデルのSPECTイメージング

  犬伏 正幸; 竹内 康人; 村井 知佳; 秦 浩信; 北川 善政; 佐賀 恒夫

  核医学, Aug. 2012

  
• Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model

  Y-N Jin; M. Inubushi; K. Masamoto; K. Odaka; I. Aoki; A. B. Tsuji; M. Sagara; M. Koizumi; T. Saga

  GENE THERAPY, Aug. 2012, Peer-reviewed

  
• Novel human monoclonal antibody against epidermal growth factor receptor as an imaging probe for hepatocellular carcinoma

  Chizuru Sogawa; Atsushi B. Tsuji; Chisato Yoshida; Masayuki Inubushi; Takako Furukawa; Mitsuru Koizumi; Yasushi Akahori; Yoshinori Ukai; Gene Kurosawa; Yoshikazu Kurosawa; Tsuneo Saga

  NUCLEAR MEDICINE COMMUNICATIONS, Jul. 2012, Peer-reviewed

  
• Roles and Limitations of FDG PET in Pediatric Non-Hodgkin Lymphoma

  Koya Nakatani; Yuji Nakamoto; Kenichiro Watanabe; Tsuneo Saga; Tatsuya Higashi; Kaori Togashi

  CLINICAL NUCLEAR MEDICINE, Jul. 2012, Peer-reviewed

  
• Evaluation of lung metastatic tumor using Dextran-DTPA-Mn nanoprobes with ultra-short echo-time imaging

  KOKURYO Daisuke; JO Jun-ichiro; SAGA Tsuneo; AOKI Ichio

  Proceeding of 20th ISMRM Scientific Meeting and Exhibition, May 2012, Peer-reviewed

  
• Giant Vesicles Containing Superparamagnetic Iron Oxide as Biodegradable Cell-Tracking MRI Probes

  Taro Toyota; Naoto Ohguri; Kouichi Maruyama; Masanori Fujinami; Tsuneo Saga; Ichio Aoki

  ANALYTICAL CHEMISTRY, May 2012, Peer-reviewed

  
• Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)

  Christoph Leuze; Yuichi Kimura; Jeff Kershaw; Sayaka Shibata; Tsuneo Saga; Kai-Hsiang Chuang; Ichiro Shimoyama; Ichio Aoki

  NEUROIMAGE, Mar. 2012, Peer-reviewed

  
• ZDHHC8 knockdown enhances radiosensitivity and suppresses tumor growth in a mesothelioma mouse model

  Hitomi Sudo; Atsushi B. Tsuji; Aya Sugyo; Yuriko Ogawa; Masashi Sagara; Tsuneo Saga

  CANCER SCIENCE, Feb. 2012, Peer-reviewed

  
• Radio labeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less rho(0) cells and cybnds carrying MELAS mitochondnal DNA mutation

  Yukie Yoshii; Makoto Yoneda; Masamichi Ikawa; Takako Furukawa; Yasushi Kiyono; Tetsuya Mori; Hiroshi Yoshii; Nobuyuki Oyama; Hidehiko Okazawa; Tsuneo Saga; Yasuhisa Fujibayashi

  NUCLEAR MEDICINE AND BIOLOGY, Feb. 2012, Peer-reviewed

  
• Disruption of Tacc3 function leads to in vivo tumor regression

  R. Yao; Y. Natsume; Y. Saiki; H. Shioya; K. Takeuchi; T. Yamori; H. Toki; I. Aoki; T. Saga; T. Noda

  ONCOGENE, Jan. 2012, Peer-reviewed

  
• Cell-penetrating nitroxides as molecular sensors for imaging of cancer in vivo, based on tissue redox activity

  Zhivko Zhelev; Veselina Gadjeva; Ichio Aoki; Rumiana Bakalova; Tsuneo Saga

  MOLECULAR BIOSYSTEMS, 2012, Peer-reviewed

  
• Single-photon emission computed tomography of spontaneous liver metastasis from orthotopically implanted human colon cancer cell line stably expressing human sodium/iodide symporter reporter gene

  Masayuki Inubushi; Yong-Nan Jin; Chika Murai; Hironobu Hata; Yoshimasa Kitagawa; Tsuneo Saga

  EJNMMI RESEARCH, 2012, Peer-reviewed

  
• Additional value of FDG-PET to contrast enhanced-computed tomography (CT) for the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Japanese multicenter clinical study

  Kazuo Kubota; Koji Murakami; Tomio Inoue; Harumi Itoh; Tsuneo Saga; Susumu Shiomi; Jun Hatazawa

  ANNALS OF NUCLEAR MEDICINE, Dec. 2011, Peer-reviewed

  
• Additional effects of FDG-PET to thin-section CT for the differential diagnosis of lung nodules: a Japanese multicenter clinical study

  Kazuo Kubota; Koji Murakami; Tomio Inoue; Tsuneo Saga; Susumu Shiomi

  ANNALS OF NUCLEAR MEDICINE, Dec. 2011, Peer-reviewed

  
• 低酸素応答性レポーター遺伝子安定発現ヒトグリオーマ細胞株の樹立

  村井 知佳; 犬伏 正幸; 金 永男; 秦 浩信; 古川 高子; 小泉 満; 佐賀 恒夫; 北川 善政

  日本口腔診断学会雑誌, Oct. 2011

  
• In Vivo Tracking of Transplanted Mononuclear Cells Using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)

  Kenichi Odaka; Ichio Aoki; Junji Moriya; Kaoru Tateno; Hiroyuki Tadokoro; Jeff Kershaw; Tohru Minamino; Toshiaki Irie; Toshimitsu Fukumura; Issei Komuro; Tsuneo Saga

  PLOS ONE, Oct. 2011, Peer-reviewed

  
• Nitroxide Derivatives for Imaging of Hypercholesterolemia-Induced Kidney Dysfunction and Assessing the Effectiveness of Antilipidemic Drugs

  Atsuyuki Tomizawa; George Hadjidekov; Itsuko Ishii; Rumiana Bakalova; Zhivko Zhelev; Ichio Aoki; Tsuneo Saga; Mitsukazu Kitada

  MOLECULAR PHARMACEUTICS, Sep. 2011, Peer-reviewed

  
• A Tumor-Environment-Responsive Nanocarrier That Evolves Its Surface Properties upon Sensing Matrix Metalloproteinase-2 and Initiates Agglomeration to Enhance T-2 Relaxivity for Magnetic Resonance Imaging

  Sachiko Matsumura; Ichio Aoki; Tsuneo Saga; Kiyotaka Shiba

  MOLECULAR PHARMACEUTICS, Sep. 2011, Peer-reviewed

  
• Evaluation of Blood-brain Barrier Development in the CNS of Neonatal Rats using Quantitative Contrast-enhanced MR Imaging with High Magnetic Field

  SAITO Shigeyoshi; SHIBATA Sayaka; SAGA Tsuneo; AOKI Ichio

  日本磁気共鳴医学会雑誌, 15 Aug. 2011

  
• Whole-Body Distribution and Brain Tumor Imaging with C-11-4DST: A Pilot Study

  Jun Toyohara; Tadashi Nariai; Muneyuki Sakata; Keiichi Oda; Kenji Ishii; Takuya Kawabe; Toshiaki Irie; Tsuneo Saga; Kazuo Kubota; Kiichi Ishiwata

  JOURNAL OF NUCLEAR MEDICINE, Aug. 2011, Peer-reviewed

  
• The potential clinical value of FDG-PET for recurrent renal cell carcinoma

  Koya Nakatani; Yuji Nakamoto; Tsuneo Saga; Tatsuya Higashi; Kaori Togashi

  European Journal of Radiology, Jul. 2011, Peer-reviewed

  
• Uptake decrease of proliferative PET tracer 18FLT in bone marrow after carbon ion therapy in lung cancer

  Mitsuru Koizumi; Tsuneo Saga; Masayuki Inubushi; Toshimitsu Fukumura; Kyosan Yoshikawa; Naoyoshi Yamamoto; Mio Nakajima; Toshio Sugane; Masayuki Baba

  Molecular Imaging and Biology, Jun. 2011, Peer-reviewed

  
• Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging

  Sumitaka Hasegawa; Michiko Koshikawa-Yano; Shigeyoshi Saito; Yukie Morokoshi; Takako Furukawa; Ichio Aoki; Tsuneo Saga

  International Journal of Cancer, 01 May 2011, Peer-reviewed

  
• Noninvasive visualization and quantification of tumor alpha(V)beta(3) integrin expression using a novel positron emission tomography probe, Cu-64-cyclam-RAFT-c(-RGDfK-)(4)

  Zhao-Hui Jin; Takako Furukawa; Mathieu Galibert; Didier Boturyn; Jean-Luc Coll; Toshimitsu Fukumura; Tsuneo Saga; Pascal Dumy; Yasuhisa Fujibayashi

  NUCLEAR MEDICINE AND BIOLOGY, May 2011, Peer-reviewed

  
• Clinical value of FDG-PET for preoperative evaluation of endometrial cancer

  Tsuyoshi Suga; Yuji Nakamoto; Tsuneo Saga; Tatsuya Higashi; Yasuyo Hamanaka; Mitsuaki Tatsumi; Kohei Hayashida; Tadashi Hara; Ikuo Konishi; Shingo Fujii; Kaori Togashi

  ANNALS OF NUCLEAR MEDICINE, May 2011, Peer-reviewed

  
• Anticancer Effect of Dihydroartemisinin (DHA) in a Pancreatic Tumor Model Evaluated by Conventional Methods and Optical Imaging

  Winn Aung; Chizuru Sogawa; Takako Furukawa; Tsuneo Saga

  ANTICANCER RESEARCH, May 2011, Peer-reviewed

  
• PET/CT with 3 '-deoxy-3 '-[F-18]fluorothymidine for lung cancer patients receiving carbon-ion radiotherapy

  Tsuneo Saga; Mitsuru Koizumi; Masayuki Inubushi; Kyosan Yoshikawa; Katsuyuki Tanimoto; Toshimitsu Fukumura; Tadaaki Miyamoto; Mio Nakajima; Naoyoshi Yamamoto; Masayuki Baba

  NUCLEAR MEDICINE COMMUNICATIONS, May 2011, Peer-reviewed

  
• An efficient and expedient method for the synthesis of C-11-labeled alpha-aminoisobutyric acid: A tumor imaging agent potentially useful for cancer diagnosis

  Koichi Kato; Atsushi B. Tsuji; Tsuneo Saga; Ming-Rong Zhang

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Apr. 2011, Peer-reviewed

  
• Development of positron emission tomography probe of Cu-64-labeled anti-C-kit 12A8 Fab to measure protooncogene C-kit expression

  Chisato Yoshida; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Chizuru Sogawa; Masayuki Inubushi; Tomoya Uehara; Toshimitsu Fukumura; Mitsuru Koizumi; Yasushi Arano; Tsuneo Saga

  NUCLEAR MEDICINE AND BIOLOGY, Apr. 2011, Peer-reviewed

  
• Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli

  Takeshi Furukawa; Kinnosuke Yahiro; Atsushi B. Tsuji; Yasuhiro Terasaki; Naoko Morinaga; Masaru Miyazaki; Yuh Fukuda; Tsuneo Saga; Joel Moss; Masatoshi Noda

  Microbial Pathogenesis, Mar. 2011, Peer-reviewed

  
• 定量的マンガン増感MRIは, 放射線照射後の早期の腫瘍細胞変性を検出する

  齋藤 茂芳; 長谷川 純崇; 古川 高子; 菅野 巖; 佐賀 恒夫; 青木 伊知男

  日本磁気共鳴医学会雑誌, 15 Feb. 2011

  
• Evaluation of ferritin-overexpressing brain in newly developed transgenic mice

  Sumitaka Hasegawa; Shigeyoshi Saito; Jun-Ichi Takanashi; Yukie Morokoshi; Takako Furukawa; Tsuneo Saga; Ichio Aoki

  Magnetic Resonance Imaging, Feb. 2011, Peer-reviewed

  
• Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics.

  Bakalova R; Zhelev Z; Kokuryo D; Spasov L; Aoki I; Saga T

  International journal of nanomedicine, 2011, Peer-reviewed

  
• 低酸素応答性レポーター遺伝子安定発現ヒトグリオーマ細胞株の樹立(Establishment of Stable Human Glioma Cell Lines Expressing Radionuclide Reporter Gene Responsive to Hypoxia)

  村井 知佳; 犬伏 正幸; 金 永男; 秦 浩信; 古川 高子; 小泉 満; 佐賀 恒夫; 北川 善政

  日本口腔診断学会雑誌, 2011, Peer-reviewed

  
• In-vivo assessment of prenatal radiation-induced hippocampal abnormalities using manganese-enhanced MRI (MEMRI)

  SAITO Shigeyoshi; SAWADA Kazuhiko; MURASE Kenya; SAGA Tsuneo; AOKI Ichio

  The Japan Radiation Research Society Annual Meeting Abstracts, 2011

  
• Tumor Enhancement Effect of Overexpressed Manganese-superoxide Dismutase in Manganese-enhanced MR Imaging

  Sumitaka Hasegawa; Shigeyoshi Saito; Michiko Koshikawa-Yano; Takako Furukawa; Ichio Aoki; Tsuneo Saga

  MAGNETIC RESONANCE IN MEDICAL SCIENCES, 2011, Peer-reviewed

  
• Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics

  Rumiana Bakalova; Zhivko Zhelev; Daisuke Kokuryo; Lubomir Spasov; Ichio Aoki; Tsuneo Saga

  INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, Peer-reviewed

  
• Diffusion tensor MRI of the kidney at 3.0 and 1.5 Tesla

  Aki Kido; Masako Kataoka; Akira Yamamoto; Yuji Nakamoto; Shigeaki Umeoka; Takashi Koyama; Yoji Maetani; Hiroyuki Isoda; Ken Tamai; Nobuko Morisawa; Tsuneo Saga; Susumu Mori; Kaori Togashi

  ACTA RADIOLOGICA, Nov. 2010, Peer-reviewed

  
• F-18 FDG PET of foreign body granuloma: Pathologic correlation with imaging features in 3 cases

  Kanae Kawai Miyake; Yuji Nakamoto; Yoshiki Mikami; Koichi Ishizu; Tsuneo Saga; Tatsuya Higashi; Kaori Togashi

  Clinical Nuclear Medicine, Nov. 2010, Peer-reviewed

  
• Characterization of FDG-PET images after stereotactic body radiation therapy for lung cancer

  Yukinori Matsuo; Yuji Nakamoto; Yasushi Nagata; Keiko Shibuya; Kenji Takayama; Yoshiki Norihisa; Masaru Narabayashi; Takashi Mizowaki; Tsuneo Saga; Tatsuya Higashi; Kaori Togashi; Masahiro Hiraoka

  Radiotherapy and Oncology, Nov. 2010, Peer-reviewed

  
• RGD-cyclam conjugate: Synthesis and potential application for positron emission tomography

  Mathieu Galibert; Zhao-Hui Jin; Takako Furukawa; Toshimitsu Fukumura; Tsuneo Saga; Yasuhisa Fujibayashi; Pascal Dumy; Didier Boturyn

  Bioorganic and Medicinal Chemistry Letters, 15 Sep. 2010, Peer-reviewed

  
• Noninvasive assessment of regulable transferred-p53 gene expression and evaluation of therapeutic response with FDG-PET in tumor model

  W. Aung; S. Hasegawa; M. Koshikawa-Yano; A. B. Tsuji; C. Sogawa; H. Sudo; A. Sugyo; M. Koizumi; T. Furukawa; T. Saga

  GENE THERAPY, Sep. 2010, Peer-reviewed

  
• Fusion protein based on Grb2-SH2 domain for cancer therapy

  Yuriko Saito; Takako Furukawa; Yasushi Arano; Yasuhisa Fujibayashi; Tsuneo Saga

  Biochemical and Biophysical Research Communications, 20 Aug. 2010, Peer-reviewed

  
• Gastrointestinal Tract Disorder in Natriuretic Peptide Receptor B Gene Mutant Mice

  Chizuru Sogawa; Asaki Abe; Takehito Tsuji; Mitsuru Koizumi; Tsuneo Saga; Tetsuo Kunieda

  AMERICAN JOURNAL OF PATHOLOGY, Aug. 2010, Peer-reviewed

  
• Basic study on SH2 domain of Grb2 as a molecular probe for detection of RTK activation

  Yuriko Saito; Takako Furukawa; Yasushi Arano; Yasuhisa Fujibayashi; Tsuneo Saga

  International Journal of Oncology, Aug. 2010, Peer-reviewed

  
• Prevalence of positive FDG-PET findings in patients with high CEA levels

  Tsuyoshi Suga; Yuji Nakamoto; Tsuneo Saga; Tatsuya Higashi; Tadashi Hara; Koichi Ishizu; Hidemitsu Nishizawa; Kaori Togashi

  Annals of Nuclear Medicine, Jul. 2010, Peer-reviewed

  
• Changes in apparent diffusion coefficients in the normal uterus during different phases of the menstrual cycle

  A. Kido; Masako Kataoka; T. Koyama; A. Yamamoto; T. Saga; K. Togashi

  British Journal of Radiology, Jun. 2010, Peer-reviewed

  
• Role of glucose metabolism and cellularity for tumor malignancy evaluation using FDG-PET/CT and MRI

  Katsuyuki Tanimoto; Kyosan Yoshikawa; Takayuki Obata; Hiroo Ikehira; Takahiro Shiraishi; Kazuhiro Watanabe; Tsuneo Saga; Junetsu Mizoe; Tadashi Kamada; Atsushi Kato; Masaru Miyazaki

  Nuclear Medicine Communications, Jun. 2010, Peer-reviewed

  
• Development of positron emission tomography imaging by Cu-64-labeled Fab for detecting ERC/mesothelin in a mesothelioma mouse model

  Chisato Yoshida; Chizuru Sogawa; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Tomoya Uehara; Okio Hino; Yukie Yoshii; Yasuhisa Fujibayashi; Toshimitsu Fukumura; Mitsuru Koizumi; Yasushi Arano; Tsuneo Saga

  NUCLEAR MEDICINE COMMUNICATIONS, May 2010, Peer-reviewed

  
• Preoperative Local Staging of Esophageal Carcinoma Using Dual-Phase Contrast-Enhanced Imaging With Multi-Detector Row Computed Tomography: Value of the Arterial Phase Images

  Shigeaki Umeoka; Takashi Koyama; Go Watanabe; Tsuneo Saga; Masako Kataoka; Kaori Togashi; Hiroto Hatabu

  JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, May 2010, Peer-reviewed

  
• Knockdown of copa, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model

  Hitomi Sudo; Atsushi B. Tsuji; Aya Sugyo; Masakazu Kohda; Chizuru Sogawa; Chisato Yoshida; Yoshi-Nobu Harada; Okio Hino; Tsuneo Saga

  Genomics, Apr. 2010, Peer-reviewed

  
• C-kit-targeted imaging of gastrointestinal stromal tumor using radiolabeled anti-c-kit monoclonal antibody in a mouse tumor model

  Chizuru Sogawa; Atsushi B. Tsuji; Hitomi Sudo; Aya Sugyo; Chisato Yoshida; Kenichi Odaka; Tomoya Uehara; Yasushi Arano; Mitsuru Koizumi; Tsuneo Saga

  NUCLEAR MEDICINE AND BIOLOGY, Feb. 2010, Peer-reviewed

  
• Effect of multimerization of a linear Arg-Gly-Asp peptide on integrin binding affinity and specificity

  Zhao-Hui Jin; Takako Furukawa; Atsuo Waki; Kenichi Akaji; Jean-Luc Coll; Tsuneo Saga; Yasuhisa Fujibayashi

  Biological and Pharmaceutical Bulletin, 2010, Peer-reviewed

  
• ヒトNa+/I-共輸送蛋白(hNIS)遺伝子安定発現大腸癌細胞株マウス担癌モデルのレポーター遺伝子イメージング

  村井 知佳; 犬伏 正幸; 志田原 美保; 辻 厚至; 小泉 満; 北川 善政; 佐賀 恒夫

  核医学, Sep. 2009

  
• 検査前確率で層別化した場合における悪性リンパ腫治療後のFDG-PETの診断精度と予後予測

  中本 裕士; 野上 宗伸; 佐賀 恒夫; 千田 道雄; 東 達也; 坂本 攝; 富樫 かおり

  核医学, Sep. 2009

  
• Significance of chronic marked hyperglycemia on FDG-PET: Is it really problematic for clinical oncologic imaging?

  Tadashi Hara; Tatsuya Higashi; Yuji Nakamoto; Tsuyoshi Suga; Tsuneo Saga; Takayoshi Ishimori; Koichi Ishizu; Hidekazu Kawashima; Shigeto Kawase; Keiichi Matsumoto; Kaori Togashi

  Annals of Nuclear Medicine, Sep. 2009, Peer-reviewed

  
• A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution

  Sumitaka Hasegawa; Kouichi Maruyama; Hikaru Takenaka; Takako Furukawa; Tsuneo Saga

  Proceedings of the National Academy of Sciences of the United States of America, 18 Aug. 2009, Peer-reviewed

  
• Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging

  W. Aung; S. Hasegawa; M. Koshikawa-Yano; T. Obata; H. Ikehira; T. Furukawa; I. Aoki; T. Saga

  GENE THERAPY, Jul. 2009, Peer-reviewed

  
• ヒトNa+/I-共輸送蛋白(hNIS)遺伝子を利用した新しい癌のin vivoイメージング法の開発

  村井 知佳; 犬伏 正幸; 秦 浩信; 北川 善政; 佐賀 恒夫

  頭頸部癌, May 2009

  
• F-18-FDG PET for Semiquantitative Evaluation of Acute Allograft Rejection and Immunosuppressive Therapy Efficacy in Rat Models of Liver Transplantation

  Atsushi B. Tsuji; Miwa Morita; Xiao-Kang Li; Chizuru Sogawa; Hitomi Sudo; Aya Sugyo; Masayuki Fujino; Atsushi Sugioka; Mitsuru Koizumi; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2009, Peer-reviewed

  
• Comparison of conventional and novel PET tracers for imaging mesothelioma in nude mice with subcutaneous and intrapleural xenografts

  Atsushi B. Tsuji; Chizuru Sogawa; Aya Sugyo; Hitomi Sudo; Jun Toyohara; Mitsuru Koizumi; Masaaki Abe; Okio Hino; Yoshi-nobu Harada; Takako Furukawa; Kazutoshi Suzuki; Tsuneo Saga

  Nuclear Medicine and Biology, May 2009, Peer-reviewed

  
• Diffusion tensor imaging of kidneys with respiratory triggering: Optimization of parameters to demonstrate anisotropic structures on fraction anisotropy maps

  Masako Kataoka; Aki Kido; Akira Yamamoto; Yuji Nakamoto; Takashi Koyama; Hiroyoshi Isoda; Yoji Maetani; Shigeaki Umeoka; Ken Tamai; Tsuneo Saga; Nobuko Morisawa; Susumu Mori; Kaori Togashi

  Journal of Magnetic Resonance Imaging, Mar. 2009, Peer-reviewed

  
• Clinical value of image fusion from MR and PET in patients with head and neck cancer

  Yuji Nakamoto; Ken Tamai; Tsuneo Saga; Tatsuya Higashi; Tadashi Hara; Tsuyoshi Suga; Takashi Koyama; Kaori Togashi

  Molecular Imaging and Biology, 2009, Peer-reviewed

  
• Comparison of semiquantitative fluorescence imaging and PET tracer uptake in mesothelioma models as a monitoring system for growth and therapeutic effects

  Yuriko Saito; Takako Furukawa; Yasushi Arano; Yasuhisa Fujibayashi; Tsuneo Saga

  Nuclear Medicine and Biology, Nov. 2008, Peer-reviewed

  
• Positron Emission Tomography for the Diagnosis and Management of Patients with Gastrointestinal Malignancies

  Tsuneo Saga; Yuji Nakamoto; Tatsuya Higashi; Kyosan Yoshikawa

  Gastrointestinal Endoscopy Clinics of North America, Jul. 2008, Peer-reviewed

  
• Software-based fusion of PET and CT images for suspected recurrent lung cancer

  Yuji Nakamoto; Michio Senda; Tomohisa Okada; Setsu Sakamoto; Tsuneo Saga; Tatsuya Higashi; Kaori Togashi

  Molecular Imaging and Biology, May 2008, Peer-reviewed

  
• The feasibility of sentinel node biopsy in the previously treated breast

  M. Koizumi; M. Koyama; K. Tada; S. Nishimura; Y. Miyagi; M. Makita; M. Yoshimoto; T. Iwase; R. Horii; F. Akiyama; T. Saga

  European Journal of Surgical Oncology, Apr. 2008, Peer-reviewed

  
• The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas

  Ken Tamai; Takashi Koyama; Tsuneo Saga; Nobuko Morisawa; Koji Fujimoto; Yoshiki Mikami; Kaori Togashi

  European Radiology, Apr. 2008, Peer-reviewed

  
• 11C-Methionine-PET for evaluation of carbon ion radiotherapy in patients with pelvic recurrence of rectal cancer

  Mitsuru Koizumi; Tsuneo Saga; Kyosan Yoshikawa; Kazutoshi Suzuki; Shigeru Yamada; Mitsuhiko Hasebe; Seiya Ohashi; Sherif Abd-Elrazek; Hiroyuki Ishikawa; Kenji Sagou; Katsumi Tamura; Ryusuke Hara; Hirotoshi Kato; Shigeo Yasuda; Takeshi Yanagi; Hirohiko Tsujii

  Molecular Imaging and Biology, 2008, Peer-reviewed

  
• Alterations in manganese, copper, and zinc contents, and intracellular status of the metal-containing superoxide dismutase in human mesothelioma cells

  Sumitaka Hasegawa; Michiko Koshikawa; Isao Takahashi; Misao Hachiya; Takako Furukawa; Makoto Akashi; Satoshi Yoshida; Tsuneo Saga

  JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2008, Peer-reviewed

  
• A loss of function screen identifies nine new radiation susceptibility genes

  Hitomi Sudo; Atsushi B. Tsuji; Aya Sugyo; Takashi Imai; Tsuneo Saga; Yoshi-Nobu Harada

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2007, Peer-reviewed

  
• MR imaging of the female pelvis at 3 Tesla: Evaluation of image homogeneity using different dielectric pads

  Masako Kataoka; Hiroyoshi Isoda; Yoji Maetani; Yuji Nakamoto; Takashi Koyama; Shigeaki Umeoka; Ken Tamai; Aki Kido; Nobuko Morisawa; Tsuneo Saga; Kaori Togashi

  JOURNAL OF MAGNETIC RESONANCE IMAGING, Dec. 2007, Peer-reviewed

  
• Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation

  Takashi Koyama; Yoshiki Mikami; Tsuneo Saga; Ken Tamai; Kaori Togashi

  ABDOMINAL IMAGING, Nov. 2007, Peer-reviewed

  
• Diffusion-weighted MR imaging of uterine endometrial cancer

  Ken Tamai; Takashi Koyama; Tsuneo Saga; Shigeaki Umeoka; Yoshiki Mikami; Shingo Fujii; Kaori Togashi

  Journal of Magnetic Resonance Imaging, Sep. 2007, Peer-reviewed

  
• Physiological changes of the human uterine myometrium during menstrual cycle: Preliminary evaluation using BOLD MR imaging

  Aki Kido; Takashi Koyama; Masako Kataoka; Akira Yamamoto; Tsuneo Saga; Robert Turner; Kaori Togashi

  JOURNAL OF MAGNETIC RESONANCE IMAGING, Sep. 2007, Peer-reviewed

  
• Potential role of ferritin heavy chain in oxidative stress and apoptosis in human mesothelial and mesothelioma cells: Implications for asbestos-induced oncogenesis

  Winn Aung; Sumitaka Hasegawa; Takako Furukawa; Tsuneo Saga

  Carcinogenesis, Sep. 2007, Peer-reviewed

  
• Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors

  Hirofumi Hanaoka; Takahiro Mukai; Sayo Habashita; Daigo Asano; Kazuma Ogawa; Yoshihiro Kuroda; Hiromichi Akizawa; Yasuhiko Iida; Keigo Endo; Tsuneo Saga; Hideo Saji

  Nuclear Medicine and Biology, Jul. 2007

  
• Small cell carcinoma of the uterine corpus: MR imaging and pathological correlation

  Ken Tamai; Takashi Koyama; Tsuneo Saga; Yoshiki Mikami; Shingo Fujii; Kaori Togashi

  Journal of Computer Assisted Tomography, May 2007, Peer-reviewed

  
• MRCP imaging at 3.0 T vs. 1.5 T: Preliminary experience in healthy volunteers

  Hiroyoshi Isoda; Masako Kataoka; Yoji Maetani; Aki Kido; Shigeaki Umeoka; Ken Tamai; Takashi Koyama; Yuji Nakamoto; Yukio Miki; Tsuneo Saga; Kaori Togashi

  Journal of Magnetic Resonance Imaging, May 2007, Peer-reviewed

  
• Cervical lymph node metastases: Diagnosis at sonoelastography - Initial experience

  Andrej Lyshchik; Tatsuya Higashi; Ryo Asato; Shinzo Tanaka; Juichi Ito; Masahiro Hiraoka; Michael F. Insana; Aaron B. Brill; Tsuneo Saga; Kaori Togashi

  Radiology, Apr. 2007, Peer-reviewed

  
• Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer

  Andrej Lyshchik; Tatsuya Higashi; Tadashi Hara; Yuji Nakamoto; Koji Fujimoto; Ryuichiro Doi; Masayuki Imamura; Tsuneo Saga; Kaori Togashi

  Cancer Investigation, Apr. 2007, Peer-reviewed

  
• MRI of the female pelvis at 3T compared to 1.5T: Evaluation on high-resolution T2-weighted and HASTE images

  Masako Kataoka; Aki Kido; Takashi Koyama; Hiroyoshi Isoda; Shigeaki Umeoka; Ken Tamai; Yuji Nakamoto; Yoji Maetani; Nobuko Morisawa; Tsuneo Saga; Kaori Togashi

  JOURNAL OF MAGNETIC RESONANCE IMAGING, Mar. 2007, Peer-reviewed

  
• Clinical value of manual fusion of PET and CT images in patients with suspected recurrent colorectal cancer

  Yuji Nakamoto; Setsu Sakamoto; Tomohisa Okada; Michio Senda; Tatsuya Higashi; Tsuneo Saga; Kaori Togashi

  American Journal of Roentgenology, Jan. 2007, Peer-reviewed

  
• MR features of physiologic and benign conditions of the ovary

  Ken Tamai; Takashi Koyama; Tsuneo Saga; Aki Kido; Masako Kataoka; Shigeaki Umeoka; Shingo Fujii; Kaori Togashi

  EUROPEAN RADIOLOGY, Dec. 2006, Peer-reviewed

  
• Evaluation of primary brain tumors with FLT-PET: Usefulness and limitations

  Tsuneo Saga; Hidekazu Kawashima; Norio Araki; Jun A. Takahashi; Yasuaki Nakashima; Tatsuya Higashi; Natsuo Oya; Takahiro Mukai; Masato Hojo; Nobuo Hashimoto; Toshiaki Manabe; Masahiro Hiraoka; Kaori Togashi

  CLINICAL NUCLEAR MEDICINE, Dec. 2006, Peer-reviewed

  
• Preoperative positron emission tomography with fluorine-18-fluorodeoxyglucose is predictive of prognosis in patients with hepatocellular carcinoma after resection.

  Etsuro Hatano; Iwao Ikai; Tatsuya Higashi; Satoshi Teramukai; Tatsuo Torizuka; Tsuneo Saga; Hideaki Fujii; Yasuyuki Shimahara

  World journal of surgery, Sep. 2006, Peer-reviewed

  
• Spectrum of MR features in adenomyosis

  Ken Tamai; Takashi Koyama; Shigeaki Umeoka; Tsuneo Saga; Shingo Fujii; Kaori Togashi

  BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY, Aug. 2006, Peer-reviewed

  
• Esophageal cancer: Evaluation with triple-phase dynamic CT - Initial experience

  Shigeaki Umeoka; Takashi Koyama; Kaori Togashi; Tsuneo Saga; Go Watanabe; Yutaka Shimada; Masayuki Imamura

  Radiology, Jun. 2006, Peer-reviewed

  
• 悪性リンパ腫におけるFDG-PET CT単独,PET単独,見比べ診断,融合画像による診断能の対比

  野上 宗伸; 中本 裕士; 坂本 攝; 福島 和人; 岡田 知久; 佐賀 恒夫; 東 達也; 千田 道雄; 杉村 和朗

  日本医学放射線学会学術集会抄録集, Feb. 2006

  
• Evaluation of malignant tumors with FLT-PET

  T. Saga; H. Kawashima; T. Higashi; Y. Nakamoto; K. Ishizu; K. Togashi

  Japanese Journal of Clinical Radiology, 2006, Peer-reviewed

  
• Diagnostic accuracy of bone metastases detection in cancer patients: Comparison between bone scintigraphy and whole-body FDG-PET

  Ryota Fujimoto; Tatsuya Higashi; Yuji Nakamoto; Tadashi Hara; Andrej Lyshchik; Koichi Ishizu; Hidekazu Kawashima; Shigeto Kawase; Toru Fujita; Tsuneo Saga; Kaori Togashi

  Annals of Nuclear Medicine, 2006, Peer-reviewed

  
• Comparison of myocardial blood flow induced by adenosine triphosphate and dipyridamole in patients with coronary artery disease

  M Mamede; E Tadamura; R Hosokawa; M Ohba; S Kubo; M Yamamuro; T Kimura; T Kita; T Saga; K Togashi

  ANNALS OF NUCLEAR MEDICINE, Dec. 2005, Peer-reviewed

  
• High F-18-fluorodeoxyglocose uptake in adrenal histoplasmosis; a case report

  S Umeoka; T Koyama; T Saga; T Higashi; N Ito; T Kamoto; H Kotani; O Ogawa; K Togashi

  EUROPEAN RADIOLOGY, Dec. 2005, Peer-reviewed

  
• Posttransplant lymphoproliferative disorder in a lung transplant recipient

  Ken Tamai; Takashi Koyama; Tsuneo Saga; Shigeaki Umeoka; Akihiro Aoyama; Nobuharu Hanaoka; Tatsuo Fukuse; Hiromi Wada; Mitsuhiro Tachibana; Kaori Togashi

  Journal of Thoracic Imaging, Nov. 2005, Peer-reviewed

  
• Ectopically located gonads in a patient with mixed gonadal dysgenesis: detection by diffusion-weighted MRI

  S Umeoka; T Koyama; T Saga; T Fujiwara; A Kido; K Fukuhara; S Fujii; K Togashi

  ABDOMINAL IMAGING, Oct. 2005, Peer-reviewed

  
• Thyroid gland tumor diagnosis at US elastography

  Andrej Lyshchik; Tatsuya Higashi; Ryo Asato; Shinzo Tanaka; Juichi Ito; Jerome J. Mal; Claire Pellot-Barakat; Michael F. Insana; Aaron B. Brill; Tsuneo Saga; Masahiro Hiraoka; Kaori Togashi

  Radiology, Oct. 2005, Peer-reviewed

  
• Positron emission tomography application for gynecologic tumors

  Yuji Nakamoto; T. Saga; S. Fujii

  International Journal of Gynecological Cancer, Sep. 2005, Peer-reviewed

  
• Effectiveness of delayed enhanced MRI for identification of cardiac sarcoidosis: Comparison with radionuclide imaging

  E Tadamura; M Yamamuro; S Kubo; S Kanao; T Saga; M Harada; M Ohba; R Hosokawa; T Kimura; T Kita; K Togashi

  AMERICAN JOURNAL OF ROENTGENOLOGY, Jul. 2005, Peer-reviewed

  
• Morphological imaging in the localization of neuroendocrine gastroenteropancreatic tumors found by somatostatin receptor scintigraphy

  T Saga; A Shimatsu; K Koizumi; T Ichikawa; K Yamamoto; S Noguchi; R Doi; M Ishibashi; R Machinami; K Nakamura; H Sakahara; K Endo

  ACTA RADIOLOGICA, May 2005, Peer-reviewed

  
• Dual-phase 18F-fluoro-2-deoxy-D-glucose positron emission tomography as a prognostic parameter in patients with pancreatic cancer

  Andrej Lyshchik; Tatsuya Higashi; Yuji Nakamoto; Koji Fujimoto; Ryuichiro Doi; Masayuki Imamura; Tsuneo Saga

  European Journal of Nuclear Medicine and Molecular Imaging, Apr. 2005, Peer-reviewed

  
• Evaluation of esophageal peristalsis in patients with esophageal tumors: Initial experience with cine MR imaging

  Takashi Koyama; Shigeaki Umeoka; Tsuneo Saga; Go Watanabe; Ken Tamai; Ari Kobayashi; Akira Hiraga; Yutaka Shimada; Kaori Togashi

  Magnetic Resonance in Medical Sciences, 2005, Peer-reviewed

  
• Elastic moduli of thyroid tissues under compression

  A. Lyshchik; T. Higashi; R. Asato; S. Tanaka; J. Ito; M. Hiraoka; A. B. Brill; T. Saga; K. Togashi

  Ultrasonic Imaging, 2005, Peer-reviewed

  
• [18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung

  Marcelo Mamede; Tatsuya Higashi; Masanori Kitaichi; Koichi Ishizu; Takayoshi Ishimori; Yuji Nakamoto; Kazuhiro Yanagihara; Mio Li; Fumihiro Tanaka; Hiromi Wada; Toshiaki Manabe; Tsuneo Saga

  Neoplasia, 2005, Peer-reviewed

  
• Quantification of human nicotinic acetylcholine receptors with 123I-5IA SPECT

  Marcelo Mamede; Koichi Ishizu; Masashi Ueda; Takahiro Mukai; Yasuhiko Iida; Hidenao Fukuyama; Tsuneo Saga; Hideo Saji

  Journal of Nuclear Medicine, 01 Sep. 2004, Peer-reviewed

  
• Tumor enhancement using Mn-metalloporphyrin in mice: Magnetic resonance imaging and histopathologic correlation

  Hatsuko Nasu; Yasuo Takehara; Satoshi Isogai; Nami Kodaira; Hiroyasu Takeda; Tsuneo Saga; Susumu Nakajima; Isao Sakata; Harumi Sakahara

  Journal of Magnetic Resonance Imaging, Aug. 2004, Peer-reviewed

  
• Hepatocyte targeting of In-111-labeled oligo-DNA with avidin or avidin-dendrimer complex

  M Mamede; T Saga; T Ishimori; T Higashi; N Sato; H Kobayashi; MW Brechbiel; J Konishi

  JOURNAL OF CONTROLLED RELEASE, Feb. 2004, Peer-reviewed

  
• Nuclear medicine practice in Japan: A report of the 5th nationwide survey in 2002

  Kiyoshi Koizumi; Nagara Tamaki; Tomio Inoue; Shinichi Kanaya; Yasuo Kuwabara; Tadako Kousaka; Yasuhiko Saiki; Tsuneo Saga; Teruki Sone; Junichi Taki; Tetsurou Yamazaki

  Annals of Nuclear Medicine, 2004, Peer-reviewed

  
• Comparison of whole-body 18F-FDG PET, 99mTc-MIBI SPET, and post-therapeutic 131I-Na scintigraphy in the detection of metastatic thyroid cancer

  Masahiro Iwata; Kanji Kasagi; Takashi Misaki; Keiichi Matsumoto; Yasuhiro Iida; Takayoshi Ishimori; Yuji Nakamoto; Tatsuya Higashi; Tsuneo Saga; Junji Konishi

  European Journal of Nuclear Medicine and Molecular Imaging, 2004, Peer-reviewed

  
• What is the most appropriate scan timing for intraoperative detection of malignancy using 18F-FDG-sensitive gamma probe? Preliminary phantom and preoperative patient study

  Tatsuya Higashi; Tsuneo Saga; Takayoshi Ishimori; Marcelo Mamede; Koichi Ishizu; Toru Fujita; Takahiro Mukai; Seiji Sato; Hironori Kato; Yoshio Yamaoka; Keiichi Matsumoto; Michio Senda; Junji Konishi

  Annals of Nuclear Medicine, 2004

  
• 18F-FDG and11C-methionine PET for evaluation of treatment response of lung cancer after stereotactic radiotherapy

  Takayoshi Ishimori; Tsuneo Saga; Yasushi Nagata; Yuji Nakamoto; Tatsuya Higashi; Marcelo Mamede; Takahiro Mukai; Yoshiharu Negoro; Tetsuya Aoki; Masahiro Hiraoka; Junji Konishi

  Annals of Nuclear Medicine, 2004

  
• Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors

  M Mamede; T Saga; H Kobayashi; T Ishimori; T Higashi; N Sato; MW Brechbiel; J Konishi

  CLINICAL CANCER RESEARCH, Sep. 2003, Peer-reviewed

  
• マンガンポルフィリン造影剤による膵癌診断の可能性についての実験的研究

  竹原 康雄; 阪原 晴海; 那須 初子; 磯貝 聡; 村松 克晃; 杉山 雅洋; 湯浅 奈美; 佐賀 恒夫; 阪田 功; 中井 敏晴

  INNERVISION, Jul. 2003

  
• [Phase III additional clinical study of 111In-pentetreotide (MP-1727): diagnosis of gastrointestinal hormone producing tumors based on the presence of somatostatin receptors]

  Saga T; Tamaki N; Itoi K; Yamazaki T; Endo K; Watanabe G; Maruno H; Machinami R; Koizumi K; Ichikawa T; Takami H; Ishibashi M; Kubo A; Kusakabe K; Hirata Y; Murata Y; Miyachi Y; Tsubuku M; Sakahara H; Katada K; Tonami N; Yamamoto K; Konishi J; Imamura M; Doi R; Shimatsu A; Noguchi S; Hasegawa Y; Ishikawa O; Watanabe Y; Nakajo M

  Kaku igaku. The Japanese Journal of Nuclear Medicine, May 2003, Peer-reviewed

  
• Clinical value of FDG-PET in the follow up of post-operative patients with endometrial cancer

  T Saga; T Higashi; T Ishimori; M Mamede; Y Nakamoto; T Mukai; T Fujita; K Togashi; S Yura; T Higuchi; M Kita; S Fujii; J Konishi

  ANNALS OF NUCLEAR MEDICINE, May 2003, Peer-reviewed

  
• Differential uptake of 18F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification

  Marcelo Mamede; Tsuneo Saga; Takayoshi Ishimori; Yuji Nakamoto; Noriko Sato; Tatsuya Higashi; Takahiro Mukai; Hisataka Kobayashi; Junji Konishi

  Neoplasia, Mar. 2003

  
• マンガンポルフィリンMR造影剤によるヒト膵癌腫瘍の信号増強に関する実験的研究

  竹原 康雄; 阪原 晴海; 那須 初子; 磯貝 聡; 小平 奈美; 杉山 雅洋; 中井 敏晴; 阪田 功; 佐賀 恒夫

  日本医学放射線学会雑誌, Feb. 2003

  
• Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose

  Yuji Nakamoto; Tsuneo Saga; Tatsuya Higashi; Takayoshi Ishimori; Hisataka Kobayashi; Koichi Ishizu; Noriko Sato; Marcelo Mamede; Harumi Sakahara; Masayuki Imamura; Junji Konishi

  Annals of Nuclear Medicine, 2003, Peer-reviewed

  
• Diagnosis of pancreatic cancer using fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) - Usefulness and limitations in "clinical reality"

  Tatsuya Higashi; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; Koji Fujimoto; Ryuichiro Doi; Masayuki Imamura; Junji Konishi

  Annals of Nuclear Medicine, 2003, Peer-reviewed

  
• 111In-ペンテトレオチド(MP-1727)第III相追加臨床試験－ソマトスタチン受容体の存在を指標とする消化管ホルモン産生腫瘍の画像診断－

  佐賀恒夫; 玉木長良; 井樋慶一

  核医学, 2003, Peer-reviewed

  
• 婦人科悪性腫瘍の診断におけるFDG-PETの臨床的有用性と医療経済効果 －多施設アンケート調査による検討－

  佐賀恒夫; 鳥塚達郎; 尾内康臣; 西澤貞彦; 米倉義晴; 越智宏暢; 深山雅人; 塩見進; 宇野公一; 小西淳二; 鳥塚莞爾

  RADIOISOTOPES, 2003, Peer-reviewed

  
• Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent

  H Kobayashi; S Kawamoto; SK Jo; N Sato; T Saga; A Hiraga; J Konishi; S Hu; K Togashi; MW Brechbiel; RA Star

  KIDNEY INTERNATIONAL, Jun. 2002, Peer-reviewed

  
• Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256)

  H Kobayashi; K Shirakawa; S Kawamoto; T Saga; N Sato; A Hiraga; Watanabe, I; Y Heike; K Togashi; J Konishi; MW Brechbiel; H Wakasugi

  CANCER RESEARCH, Feb. 2002, Peer-reviewed

  
• Assessment of a potential tumor-seeking manganese metalloporphyrin contrast agent in a mouse model

  Yasuo Takehara; Harumi Sakahara; Hatsuko Masunaga; Satoshi Isogai; Nami Kodaira; Masahiro Sugiyama; Hiroyasu Takeda; Tsuneo Saga; Susumu Nakajima; Isao Sakata

  Magnetic Resonance in Medicine, 2002, Peer-reviewed

  
• Increased 18F-FDG uptake in a model of inflammation: Concanavalin A-mediated lymphocyte activation

  Takayoshi Ishimori; Tsuneo Saga; Marcelo Mamede; Hisataka Kobayashi; Tatsuya Higashi; Yuji Nakamoto; Noriko Sato; Junji Konishi

  Journal of Nuclear Medicine, 2002, Peer-reviewed

  
• Dynamic micro-MRI of liver micrometastasis with a novel liver macromolecular MR contrast agent DAB-Am64-(1B4M-Gd)64

  Hisataka Kobayashi; Tsuneo Saga; Satomi Kawamoto; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Academic Radiology, 2002, Peer-reviewed

  
• Control of radioactivity pharmacokinetics of 99mTc-HYNIC-labeled polypeptides derivatized with ternary ligand complexes

  Masahiro Ono; Yasushi Arano; Takahiro Mukai; Tsuneo Saga; Yasushi Fujioka; Kazuma Ogawa; Hidekazu Kawashima; Junji Konishi; Hideo Saji

  Bioconjugate Chemistry, 2002

  
• Relationship between retention index in dual-phase 18F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer

  Tatsuya Higashi; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; Marcelo H. Mamede; Michihiko Wada; Ryuichiro Doi; Ryo Hosotani; Masayuki Imamura; Junji Konishi

  Journal of Nuclear Medicine, 2002, Peer-reviewed

  
• Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores

  N Sato; H Kobayashi; A Hiraga; T Saga; K Togashi; J Konishi; MW Brechbiel

  MAGNETIC RESONANCE IN MEDICINE, Dec. 2001, Peer-reviewed

  
• Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64)

  H Kobayashi; T Saga; S Kawamoto; N Sato; A Hiraga; T Ishimori; J Konishi; K Togashi; MW Brechbiel

  CANCER RESEARCH, Jul. 2001, Peer-reviewed

  
• Enhancement of the therapeutic outcome of radio-immunotherapy by combination with whole-body mild hyperthermia

  T Saga; H Sakahara; Y Nakamoto; N Sato; T Ishimori; M Mamede; H Kobayashi; S Masunaga; K Sasai; M Kuroki; J Konishi

  EUROPEAN JOURNAL OF CANCER, Jul. 2001, Peer-reviewed

  
• Tumour enhancement with newly developed Mn-metalloporphyrin (HOP-9P) in magnetic resonance imaging of mice

  Y. Takehara; H. Sakahara; H. Masunaga; S. Isogai; N. Kodaira; H. Takeda; T. Saga; S. Nakajima; I. Sakata

  British Journal of Cancer, 15 Jun. 2001, Peer-reviewed

  
• すい癌のＦＤＧ‐ＰＥＴ診断

  東 達也; 佐賀 恒夫; 石守 崇好; 小西 淳二

  RADIOISOTOPES, 2001

  
• Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: Reference to pharmacokinetic properties of dendrimer-based MR contrast agents

  Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Journal of Magnetic Resonance Imaging, 2001, Peer-reviewed

  
• Clinical value of positron emission tomography with FDG for recurrent ovarian cancer

  Y. Nakamoto; T. Saga; T. Ishimori; M. Mamede; K. Togashi; T. Higuchi; M. Mandai; S. Fujii; H. Sakahara; J. Konishi

  American Journal of Roentgenology, 2001, Peer-reviewed

  
• Avidin-dendrimer-(1B4M-Gd)254: A tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI

  H. Kobayashi; S. Kawamoto; T. Saga; N. Sato; T. Ishimori; J. Konishi; K. Ono; K. Togashi; M. W. Brechbiel

  Bioconjugate Chemistry, 2001, Peer-reviewed

  
• Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice

  Noriko Sato; Hisataka Kobayashi; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; Kaori Togashi; Yasuhisa Fujibayashi; Junji Konishi; Martin W. Brechbiel

  Clinical Cancer Research, 2001, Peer-reviewed

  
• Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer

  H. Kobayashi; N. Sato; S. Kawamoto; T. Saga; A. Hiraga; T. Laz Haque; T. Ishimori; J. Konishi; K. Togashi; M. W. Brechbiel

  Bioconjugate Chemistry, 2001, Peer-reviewed

  
• 3D-Micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties

  Hisataka Kobayashi; Noriko Sato; Akira Hiraga; Tsuneo Saga; Yuji Nakamoto; Hiroyuki Ueda; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Magnetic Resonance in Medicine, 2001, Peer-reviewed

  
• Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: Accelerated renal excretion with coinjection of lysine

  Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Magnetic Resonance in Medicine, 2001, Peer-reviewed

  
• 3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent

  Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Magnetic Resonance in Medicine, 2001, Peer-reviewed

  
• Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: Comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core

  Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Yukio Akita; Marcelo H. Mamede; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Magnetic Resonance in Medicine, 2001, Peer-reviewed

  
• Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents

  Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W. Brechbiel

  Magnetic Resonance in Medicine, 2001, Peer-reviewed

  
• Plasma protein binding of 99mTc-labeled hydrazino nicotinamide derivatized polypeptides and peptides

  Masahiro Ono; Yasushi Arano; Takahiro Mukai; Tomoya Uehara; Yasushi Fujioka; Kazuma Ogawa; Shinji Namba; Morio Nakayama; Tsuneo Saga; Junji Konishi; Kazuko Horiuchi; Akira Yokoyama; Hideo Saji

  Nuclear Medicine and Biology, 2001

  
• Renal metabolism of 3′-iodohippuryl N∈-maleoyl-L-lysine (HML)-conjugated fab fragments

  Y. Fujioka; Y. Arano; M. Ono; T. Uehara; K. Ogawa; S. Namba; T. Saga; Y. Nakamoto; T. Mukai; J. Konishi; H. Saji

  Bioconjugate Chemistry, 2001

  
• 99mTc-HYNIC-derivatized ternary ligand complexes for 99mTc-labeled polypeptides with low in vivo protein binding

  Masahiro Ono; Yasushi Arano; Takahiro Mukai; Yasushi Fujioka; Kazuma Ogawa; Tomoya Uehara; Tsuneo Saga; Junji Konishi; Hideo Saji

  Nuclear Medicine and Biology, 2001

  
• Combined effects of tirapazamine and mild hyperthermia on anti- angiogenic agent (TNP-470) treated tumors - Reference to the effect on intratumor quiescent cells

  Shin-Ichiro Masunaga; Koji Ono; Yasumasa Nishimura; Shuichi Kanamori; Tsuneo Saga; Minoru Suzuki; Yuko Kinashi; Masao Takagaki; Soko Kasai; Hideko Nagasawa; Yoshihiro Uto; Hitoshi Hori

  International Journal of Radiation Oncology Biology Physics, 01 Jun. 2000, Peer-reviewed

  
• Clinical impact of FDG-PET for follow-up patients with gynecological malignancies

  Y Nakamoto; T Saga; T Ishimori; K Togashi; T Higuchi; S Fujii; H Sakahara; J Konishi

  POSITRON EMISSION TOMOGRAPHY IN THE MILLENNIUM, 2000, Peer-reviewed

  
• Establishment and characterization of a breast cancer cell line expressing Na+/I- symporters for radioiodide concentrator gene therapy

  Y. Nakamoto; T. Saga; T. Misaki; H. Kobayashi; N. Sato; T. Ishimori; S. Kosugi; H. Sakahara; J. Konishi

  Journal of Nuclear Medicine, 2000, Peer-reviewed

  
• Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity

  Hisataka Kobayashi; Noriko Sato; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; Sakuji Toyama; Kaori Togashi; Junji Konishi; Martin W. Brechbiel

  European Journal of Nuclear Medicine, 2000, Peer-reviewed

  
• Avidin chase can reduce myelotoxicity associated with radioimmunotherapy of experimental liver micrometastases in mice

  Noriko Sato; Tsuneo Saga; Harumi Sakahara; Yuji Nakamoto; Songji Zhao; Masahide Kuroki; Yasuhiko Iida; Keigo Endo; Junji Konishi

  Japanese Journal of Cancer Research, 2000, Peer-reviewed

  
• Asialoglycoprotein receptor scintigraphy in evaluation of auxiliary partial orthotopic liver transplantation

  H Sakahara; T Kiuchi; S Nishizawa; T Saga; Y Nakamoto; N Sato; T Higashi; K Tanaka; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, Sep. 1999, Peer-reviewed

  
• Radioimmunotherapy of human glioma xenografts in nude mice by indium-111 labelled internalising monoclonal antibody

  T Saga; H Sakahara; Y Nakamoto; N Sato; S Zhao; T Aoki; S Miyatake; Y Namba; J Konishi

  EUROPEAN JOURNAL OF CANCER, Aug. 1999, Peer-reviewed

  
• Induction of vascular endothelial growth factor (VEGF) by hyperthermia and/or an angiogenesis inhibitor

  S. Kanamori; Y. Nishimura; Y. Okuno; N. Horii; T. Saga; M. Hiraoka

  International Journal of Hyperthermia, Jul. 1999, Peer-reviewed

  
• Intratumoral distribution of radiolabeled antibody and radioimmunotherapy in experimental liver metastases model of nude mouse

  Noriko Sato; Tsuneo Saga; Harumi Sakahara; Zhengsheng Yao; Yuji Nakamoto; Meili Zhang; Masahide Kuroki; Yuji Matsuoka; Yasuhiko Iida; Junji Konishi

  Journal of Nuclear Medicine, Apr. 1999, Peer-reviewed

  
• Radioimmunotherapy for liver micrometastases in mice: Pharmacokinetics, dose estimation, and long-term effect

  T Saga; H Sakahara; Y Nakamoto; N Sato; SJ Zhao; Y Iida; M Kuroki; K Endo; J Konishi

  JAPANESE JOURNAL OF CANCER RESEARCH, Mar. 1999, Peer-reviewed

  
• A novel 111In-labeled antisense DNA probe with multi-chelating sites (MCS-probe) showing high specific radioactivity and labeling efficiency

  Yasuhisa Fujibayashi; Eiji Yoshimi; Atsuo Waki; Harumi Sakahara; Tsuneo Saga; Junji Konishi; Yoshiharu Yonekura; Akira Yokoyama

  Nuclear Medicine and Biology, Jan. 1999, Peer-reviewed

  
• A navel immunoscintigraphy technique using metabolizable linker with angiotensin II treatment

  Y. Nakamoto; H. Sakahara; T. Saga; N. Sato; S. Zhao; Y. Arano; Y. Fujioka; H. Saji; J. Konishi

  British Journal of Cancer, 1999, Peer-reviewed

  
• Increased streptavidin uptake in tumors pretargeted with biotinylated antibody using a conjugate of streptavidin-Fab fragment

  ZS Yao; ML Zhang; H Sakahara; T Saga; H Kobayashi; Y Nakamoto; S Toyama; J Konishi

  NUCLEAR MEDICINE AND BIOLOGY, Aug. 1998, Peer-reviewed

  
• Three-step tumor imaging with biotinylated monoclonal antibody, streptavidin and 111In-DTPA-biotin

  Yuji Nakamoto; Tsuneo Saga; Harumi Sakahara; Zheng-Sheng Yao; Meili Zhang; Noriko Sato; Song-Ji Zhao; Hiroshi Nakada; Ikuo Yamashina; Junji Konishi

  Nuclear Medicine and Biology, Feb. 1998

  
• Effect of administration route and dose of streptavidin or biotin on the tumor uptake of radioactivity in intraperitoneal tumor with multistep targeting

  Meili Zhang; Zhengsheng Yao; Harumi Sakahara; Tsuneo Saga; Yuji Nakamoto; Noriko Sato; Songji Zhao; Hiroshi Nakada; Ikuo Yamashina; Junji Konishi

  Nuclear Medicine and Biology, Feb. 1998, Peer-reviewed

  
• Avidin targeting of intraperitoneal tumor xenografts

  Zhengsheng Yao; Meili Zhang; Harumi Sakahara; Tsuneo Saga; Yasushi Arano; Junji Konishi

  Journal of the National Cancer Institute, 07 Jan. 1998, Peer-reviewed

  
• Gallstone ileus with impaction at the neck of a Meckel's diverticulum

  Y. Nakamoto; T. Saga; S. Fujishiro; M. Washida; M. Churiki; K. Matsuda

  British Journal of Radiology, 1998, Peer-reviewed

  
• Imaging of intraperitoneal tumors with technetium-99m GSA

  Zhengsheng Yao; Meili Zhang; Harumi Sakahara; Tsuneo Saga; Yuji Nakamoto; Noriko Sato; Songji Zhao; Yasushi Arano; Junji Konishi

  Annals of Nuclear Medicine, 1998, Peer-reviewed

  
• A radioiodinated biocytin derivative for in-vivo applications

  Yuji Nakamoto; H. Sakahara; T. Saga; Z. Yao; M. Zhang; N. Sato; S. Zhao; J. Konishi; Y. Arano; M. Ono; H. Saji

  Nuclear Medicine Communications, 1998, Peer-reviewed

  
• Detection of altered adhesion molecule expression in experimental tumors by a radiolabeled monoclonal antibody

  T Saga; H Sakahara; ZS Yao; Y Nakamoto; N Sato; N Hattori; M Zhang; SJ Zhao; T Aoki; S Miyatake; Y Namba; J Konishi

  JAPANESE JOURNAL OF CANCER RESEARCH, Dec. 1997, Peer-reviewed

  
• Value of low-dose gallium-67 imaging in detection of non-Hodgkin's lymphoma recurrence

  M. Nakayama; H. Sakahara; Y. Minowa; K. Sasai; T. Ishigaki; T. Saga; Y. Nakamoto; Z. Yao; M. Hiraoka; K. Sakai; J. Konishi

  Radiation Medicine - Medical Imaging and Radiation Oncology, 1997, Peer-reviewed

  
• Immunohistochemical characterization of 22 monoclonal antibodies against the ca125 antigen: 2nd report from the isobm td-1 workshop

  Marius Nap; A. Vitali; K. Nustad; R. C. Bast; T. J. O’brienc; D. Nilsson; P. Seguin; M. R. Suresh; O. P. Børmer; T. Saga; H. W.A. de Bruijn; S. Nozawa; F. T. Kreutz; D. Jette; H. Sakahara; M. Gadnell; K. Endo; E. H. Barlow; D. Warren; E. Paus; S. Hammarström; P. Kenemans; J. Hilgers

  Tumor Biology, 01 Jan. 1996, Peer-reviewed

  
• Specificity and affinity of 26 monoclonal antibodies against the CA 125 antigen: First report from the ISOBM TD-1 workshop

  K. Nustad; R. C. Bast; T. J. O’brien; O. Nilsson; P. Seguin; M. R. Suresh; T. Saga; S. Nozawa; O. P. Børmer; H. W.A. de Bruijn; M. Nap; A. Vitali; M. Gadnell; J. Clark; K. Shigemasa; B. Karlsson; F. T. Kreutz; D. Jette; H. Sakahara; K. Endo; E. Paus; D. Warren; S. Hammarström; P. Kenemans; J. Hilgers

  Tumor Biology, 01 Jan. 1996, Peer-reviewed

  
• Clinical evaluation of TPA-assay kit using monoclonal antibodies

  T. Saga; H. Sakahara; T. Kousaka; Z. Yao; Y. Nakamoto; N. Hattori; M. Zhang; M. Nakayama; G. Ohshio; M. Imamura; J. Konishi

  Japanese Journal of Cancer and Chemotherapy, 1996, Peer-reviewed

  
• Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using Anti-CA125 monoclonal antibody

  Harumi Sakahara; Makoto Hosono; Hisataka Kobayashi; Zhengsheng Yao; Tsuneo Saga; Shinsuke Yano; Keigo Endo; Takahide Mori; Junji Konishi

  Japanese Journal of Cancer Research, 1996, Peer-reviewed

  
• モノクローナル抗体を用いたTPAアッセイキット、プロリフィゲンTPA-M"第一"の臨床的検討

  佐賀恒夫; 阪原晴海; 高坂唯子; 姚 正生; 中本裕士; 服部典子; 張 美麗; 中山マウロ; 大塩学而; 今村正之; 小西淳二

  癌と化学療法, 1996, Peer-reviewed

  
• Nonenhanced hepatic cavernous hemangioma with multiple calcifications: CT and pathologic correlation

  K. Mitsudo; Y. Watanabe; T. Saga; M. Dohke; N. Sato; K. Minami; M. Shigeyasu

  Abdominal Imaging, Sep. 1995, Peer-reviewed

  
• Adrenocortical adenoma containing a fat component: CT and MR image evaluation

  N. Sato; Y. Watanabe; T. Saga; K. Mitsudo; M. Dohke; K. Minami

  Abdominal Imaging, Sep. 1995, Peer-reviewed

  
• TARGETING CANCER MICROMETASTASES WITH MONOCLONAL-ANTIBODIES - A BINDING-SITE BARRIER

  T SAGA; RD NEUMANN; T HEYA; J SATO; S KINUYA; N LE; CH PAIK; JN WEINSTEIN

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 1995, Peer-reviewed

  
• Retained placenta accreta: mri and pathologic correlation

  Yoshiki Amoh; Yuji Watanabe; Tsuneo Saga; Masako Dohke; Noriko Sato; Kazuyo Mitsudo; Takashi Nakahori; Masahiko Ukita

  Journal of Computer Assisted Tomography, 1995, Peer-reviewed

  
• Kinetics of platelets in dogs with thrombocytopenia induced by antiglycoprotein IIb/IIIa receptor monoclonal antibody

  Makoto Hosono; Naoaki Sone; Keigo Endo; Tsuneo Saga; Hisataka Kobayashi; Masako N. Hosono; Harumi Sakahara; Kojiro Yasunaga; Junji Konishi

  Nuclear Medicine and Biology, 1995, Peer-reviewed

  
• KINETICS OF PLATELETS IN DOGS WITH THROMBOCYTOPENIA INDUCED BY ANTIGLYCOPROTEIN IIB/IIIA RECEPTOR MONOCLONAL-ANTIBODY

  M HOSONO; N SONE; K ENDO; T SAGA; H KOBAYASHI; MN HOSONO; H SAKAHARA; K YASUNAGA; J KONISHI

  NUCLEAR MEDICINE AND BIOLOGY, Jan. 1995, Peer-reviewed

  
• 131I-metaiodobenzylguanidine therapy for malignant pheochromocytoma

  Harumi Sakahara; Keigo Endo; Tsuneo Saga; Makoto Hosono; Hisataka Kobayashi; Junji Konishi

  Annals of Nuclear Medicine, Jun. 1994, Peer-reviewed

  
• 2-STEP TARGETING OF EXPERIMENTAL LUNG METASTASES WITH BIOTINYLATED ANTIBODY AND RADIOLABELED STREPTAVIDIN

  T SAGA; JN WEINSTEIN; JM JEONG; T HEYA; JT LEE; N LE; CH PAIK; C SUNG; RD NEUMANN

  CANCER RESEARCH, Apr. 1994, Peer-reviewed

  
• Changes in CA125 release and surface expression caused by drugs in uterine cervix adenocarcinoma cells

  Toshiharu Nakai; Harumi Sakahara; Keigo Endo; Makoto Shirato; Hisataka Kobayashi; Makoto Hosono; Tsuneo Saga; Masaru Sakamoto; Junji Konishi

  Annals of Nuclear Medicine, Sep. 1993, Peer-reviewed

  
• A human/mouse chimeric monoclonal antibody against CA125 for radioimmunoimaging of ovarian cancer

  Hisataka Kobavashi; Harumi Sakahara; Tsuneo Saga; Makoto Hosono; Makoto Shirato; Hidetoshi Kanda; Kaichiro Ishibashi; Takeshi Watanabe; Keigo Endo; Isamu Ishiwata; Junji Konishi

  Cancer Immunology Immunotherapy, May 1993, Peer-reviewed

  
• In vivo instability of reduction-mediated 99mTc-labeled monoclonal antibody

  Harumi Sakahara; Tsuneo Saga; Keigo Endo; Noriko Hattori; Makoto Hosono; Hisataka Kobayashi; Makoto Shirato; Takao Yamamuro; Sakuji Toyama; Yasuo Arano; Akira Yokoyama; Junji Konishi

  Nuclear Medicine and Biology, 1993, Peer-reviewed

  
• Similarity and co-expression of tumour-associated antigens recognised by different monoclonal antibodies

  H. Sakahara; T. Saga; K. Endo; T. Kousakal; M. Hosono; H. Kobayashi; M. Shirato; J. Konishi

  British Journal of Cancer, 1993, Peer-reviewed

  
• Construction of Immunoradiometric Assay for Circulating c‐erbB‐2 Protooncogene Product in Advanced Breast Cancer Patients

  Makoto Hosono; Tsuneo Saga; Harumi Sakahara; Hisataka Kobayashi; Makoto Shirato; Keigo Endo; Tadashi Yamamoto; Tetsu Akiyama; Kumao Toyoshima; Junji Konishi

  Japanese Journal of Cancer Research, 1993, Peer-reviewed

  
• DIFFERENT ANTIGENIC NATURE IN APPARENTLY HEALTHY WOMEN WITH HIGH SERUM CA-125 LEVELS COMPARED WITH TYPICAL PATIENTS WITH OVARIAN-CANCER

  MN HOSONO; K ENDO; H SAKAHARA; Y WATANABE; T SAGA; T NAKAI; M HOSONO; T NAKAJIMA; Y ONOYAMA; J KONISHI

  CANCER, Dec. 1992, Peer-reviewed

  
• HUMAN MOUSE CHIMERIC ANTIBODIES SHOW LOW REACTIVITY WITH HUMAN ANTIMURINE ANTIBODIES (HAMA)

  M HOSONO; K ENDO; H SAKAHARA; Y WATANABE; T SAGA; T NAKAI; C KAWAI; A MATSUMORI; T YAMADA; T WATANABE; J KONISHI

  BRITISH JOURNAL OF CANCER, Feb. 1992, Peer-reviewed

  
• Hepatocyte response to continuous low dose-rate radiation in radioimmunotherapy assessed by micronucleus assay

  H. Sakahara; K. Ono; T. Saga; K. Akuta; K. Endo; J. Konishi; M. Abe

  International Journal of Radiation Biology, 1992, Peer-reviewed

  
• SCINTIGRAPHIC DETECTION OF OVEREXPRESSED C-ERBB-2 PROTOONCOGENE PRODUCTS BY A CLASS-SWITCHED MURINE ANTI-C-ERBB-2 PROTEIN MONOCLONAL-ANTIBODY

  T SAGA; K ENDO; T AKIYAMA; H SAKAHARA; M KOIZUMI; Y WATANABE; T NAKAI; M HOSONO; T YAMAMOTO; K TOYOSHIMA; J KONISHI

  CANCER RESEARCH, Feb. 1991, Peer-reviewed

  
• An approach for immunoradiometric assay with metallic radionuclides: Gallium-67-deferoxamine-dialdehyde starch-IgG

  T. Furukawa; Y. Fujibayashi; M. Fukunaga; T. Saga; K. Endo; A. Yokoyama

  Journal of Nuclear Medicine, 1991, Peer-reviewed

  
• Drug effects on CA125 antigen expression and antibody binding to cancer cells

  Toshiharu Nakai; Keigo Endo; Makoto Hosono; Tsuneo Saga; Yuji Watanabe; Harumi Sakahara; Kozoh Imai; Akira Yachi; Yasuhiko Kivozuka; Isamu Ishiwata; Junji Konishi

  International Journal of Cancer, 1991, Peer-reviewed

  
• AN ANTIBODY-TUMOR MODEL FOR THE TARGETING OF CA125-PRODUCING GYNECOLOGIC MALIGNANCIES

  T SAGA; ISHIWATA, I; K ENDO; H SAKAHARA; M KOIZUMI; Y WATANABE; T NAKAI; M HOSONO; H ISHIKAWA; M SAWADA; J KONISHI

  JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1990, Peer-reviewed

  
• INVITRO AND INVIVO PROPERTIES OF HUMAN MOUSE CHIMERIC MONOCLONAL-ANTIBODY SPECIFIC FOR COMMON ACUTE LYMPHOCYTIC-LEUKEMIA ANTIGEN

  T SAGA; K ENDO; M KOIZUMI; Y KAWAMURA; Y WATANABE; J KONISHI; R UEDA; Y NISHIMURA; M YOKOYAMA; T WATANABE

  JOURNAL OF NUCLEAR MEDICINE, Jun. 1990, Peer-reviewed

  
• USE OF MAGNETITE PARTICLES AS A CONTRAST AGENT FOR MR IMAGING OF THE LIVER

  Y KAWAMURA; K ENDO; Y WATANABE; T SAGA; T NAKAI; H HIKITA; K KAGAWA; J KONISHI

  RADIOLOGY, Feb. 1990, Peer-reviewed

  
• NORMAL BRONCHIAL MUCUS CONTAINS HIGH-LEVELS OF CANCER-ASSOCIATED ANTIGENS, CA125, CA19-9, AND CARCINOEMBRYONIC ANTIGEN

  Y MATSUOKA; K ENDO; Y KAWAMURA; T YOSHIDA; T SAGA; Y WATANABE; M KOIZUMI; T NAKASHIMA; J KONISHI; N YAMAGUCHI; R YATANI

  CANCER, Feb. 1990, Peer-reviewed

  
• Levels of CA130 in maternal sera and amniotic fluid at various gestational ages

  F. Kobayashi; N. Sagawa; A. Okagaki; K. Nakamura; M. Nonogaki; Y. Nanbu; C. Ban; S. Fujii; T. Mori; T. Saga; K. Endo

  Acta Obstetrica et Gynaecologica Japonica, 1990, Peer-reviewed

  
• Estrogen‐ and androgen‐responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

  Masumi Sawada; Nobuyuki Terada; Akira Wada; Yoichi Mori; Masato Yamasaki; Tsuneo Saga; Keigo Endo

  International Journal of Cancer, 1990, Peer-reviewed

  
• Immunohistochemical Localization of CA130 in Fetal Tissues, and in Normal and Neoplastic Tissues of the Female Genital Tract

  Yoshihiko Nanbu; Shingo Fujii; Ikuo Konishi; Hirofumi Nonogaki; Norimasa Sagawa; Fuminori Kobayashi; Takahide Mori; Tsuneo Saga; Keigo Endo

  Asia‐Oceania Journal of Obstetrics and Gynaecology, 1990, Peer-reviewed

  
• Influence of Cocktails of Labeled Monoclonal Antibodies on the Localization of Antibodies in Human Tumor Xenografts

  Yuji Watanabe; Keigo Endo; Tsuneo Saga; Mitsuru Koizumi; Harumi Sakahara; Toshiharu Nakai; Makoto Hosono; Zheng‐Sheng Yao; Masahide Kuroki; Yuji Matsuoka; Junji Konishi

  Japanese Journal of Cancer Research, 1990, Peer-reviewed

  
• CONSTRUCTION OF AN IMMUNORADIOMETRIC ASSAY FOR OVARIAN-CANCER ASSOCIATED ANTIGEN CA125 RECOGNIZING DIFFERENT ANTIGENIC DETERMINANT

  T SAGA; K ENDO; T NAKASHIMA; T AWAJI; M KOIZUMI; Y KAWAMURA; Y WATANABE; J KONISHI; H NONOGAKI; Y NANBU; S FUJII; T MORI

  ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1990, Peer-reviewed

  
• CT MANIFESTATIONS OF A RUPTURED HEPATIC TUMOR AFTER TRANSCATHETER ARTERIAL EMBOLIZATION

  Y NAGATA; S KOHNO; T SAGA; K OKAJIMA; M HOSONO; M TAMAKI; T KANATA; A TAKABAYASHI; S MATSUDA

  COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, Sep. 1989, Peer-reviewed

  
• Effect of Tumor Mass and Antigenic Nature on the Biodistribution of Labeled Monoclonal Antibodies in Mice

  Yuji Watanabe; Keigo Endo; Mitsuru Koizumi; Yasutaka Kawamura; Tsuneo Saga; Harumi Sakahara; Junji Konishi; Masahide Kuroki; Yuji Matsuoka

  Cancer Research, 01 Jun. 1989, Peer-reviewed

  
• PHARMACOKINETICS OF INTERNALLY LABELED MONOCLONAL-ANTIBODIES AS A GOLD STANDARD - COMPARISON OF BIODISTRIBUTION OF SE-75-LABELED, IN-111-LABELED, AND I-125-LABELED MONOCLONAL-ANTIBODIES IN OSTEOGENIC-SARCOMA XENOGRAFTS IN NUDE-MICE

  M KOIZUMI; K ENDO; Y WATANABE; T SAGA; H SAKAHARA; J KONISHI; T YAMAMURO; S TOYAMA

  CANCER RESEARCH, Apr. 1989, Peer-reviewed

  
• GADOLINIUM-PHTHALEIN COMPLEXONE AS A CONTRAST AGENT FOR HEPATOBILIARY MR IMAGING

  Y KAWAMURA; K ENDO; M KOIZUMI; Y WATANABE; T SAGA; J KONISHI; K HORIUCHI; A YOKOYAMA

  JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, Jan. 1989, Peer-reviewed

  
• Differences in tumor localization of anti-CEA monoclonal antibodies with different epitope specificities

  Watanabe Y; Endo K; Koizumi M; Kawamura Y; Saga T; Nakai T; Sakahara H; Konishi J; Kuroki M; Matsuoka Y

  J Nucl Med, 1989, Peer-reviewed

  
• Cocktails of labeled monoclonal antibodies do not improve the localization in human tumor xenografts

  Watanabe Y; Endo K; Koizumi M; Kawamura Y; Saga T; Nakai T; Kuroki M; Sakahara H; Konishi J; Matsuoka Y

  J Nucl Med, 1989, Peer-reviewed

  
• Development of new immunoradiometric assay for CA 125 antigen using two monoclonal antibodies produced by immunizing lung cancer cells

  Mihoko Kunimatsu; Keigo Endo; Tetsuo Nakashima; Toshikazu Awaji; Tsuneo Saga; Yuji Watanabe; Yasutaka Kawamura; Hitoya Ohta; Mitsuru Koizumi; Harumi Sakahara; Junji Konishi; Shingo Fujii; Takahide Mori; Kanji Torizuka; Yoichiro Matsuoka; Tsuyoshi Nakagawa; Nobuo Yamaguchi

  Annals of Nuclear Medicine, Dec. 1988, Peer-reviewed

  
• IMMUNOSCINTIGRAPHY AND PHARMACOKINETICS OF INDIUM-111-LABELED ZME-018 MONOCLONAL-ANTIBODY IN PATIENTS WITH MALIGNANT-MELANOMA

  M KOIZUMI; K ENDO; Y WATANABE; T SAGA; H SAKAHARA; J KONISHI; Y ARANO; Y MIYACHI; M KASHIHARASAWAMI; S IMAMURA

  JAPANESE JOURNAL OF CANCER RESEARCH, Aug. 1988, Peer-reviewed

  
• SEMIQUANTITATIVE INVITRO BINDING ASSAY OF INDIUM-111-LABELED MONOCLONAL-ANTIBODIES TO HUMAN CANCER AND NORMAL-TISSUES

  Y WATANABE; K ENDO; M KOIZUMI; H SAKAHARA; Y KAWAMURA; T SAGA; J KONISHI; G OHSHIO; T MANABE; R TOBE

  JOURNAL OF NUCLEAR MEDICINE, Aug. 1988, Peer-reviewed

  
• Transcatheter Arterial Embolization for Osseous Metastasis of Hepatocellular Carcinoma

  Nagata Yasushi; Nakano Yoshihisa; Takahashi Masaji; Abe Mitsuyuki; Saga Tsuneo; Okajima Kaoru; Hosono Makoto; Kohno Shigene

  日本医学放射線学会雑誌, 25 Apr. 1988

  
• GA-67-LABELED ANTIBODIES FOR IMMUNOSCINTIGRAPHY AND EVALUATION OF TUMOR TARGETING OF DRUG-ANTIBODY CONJUGATES IN MICE

  M KOIZUMI; K ENDO; M KUNIMATSU; H SAKAHARA; T NAKASHIMA; Y KAWAMURA; Y WATANABE; T SAGA; J KONISHI; T YAMAMURO; S HOSOI; S TOYAMA; Y ARANO; A YOKOYAMA

  CANCER RESEARCH, Mar. 1988, Peer-reviewed

  
• モノクローナル抗体を用いたＣＡ１３０ＲＩＡキット(D-7111)の基礎的ならびに臨床的検討；ＣＡ１２５キットとの比較

  佐賀恒夫; 遠藤啓吾; 中島鉄夫; 中島言子; 松岡洋一郎; 小泉 満; 河村泰孝; 渡辺祐司; 羽藤明子; 国松美帆子; 小西淳二; 藤井信吾; 森崇英

  核医学, 1988, Peer-reviewed

  
• Fundamental and clinical evaluation of 'SCC RIABEAD' kit for immunoradiometric assay of squamous cell carcinoma related antigen

  M. Koizuma; K. Endo; K. Nakajima; H. Sakahara; Y. Kawamura; Y. Watanabe; T. Saga; M. Kunimatsu; J. Konishi; Y. Matsui; S. Fujii; T. Mori

  Kakuigaku, 1987, Peer-reviewed

  
• CT diagnosis of periureteric venous ring

  Naoki Hattori; Jum Fujikawa; Katsuhiko Kubo; Tsuneo Saga; Yasushi Nagata; Shigene Kohno; Masaya Tanabe

  Journal of Computer Assisted Tomography, 1986, Peer-reviewed

  

Misc.

• 非侵襲的膵β細胞量評価の実現を目指した,¹⁸F標識PEG化GLP-1受容体標的プローブPET/CTの開発:第1相臨床試験追加解析を踏まえて

  村上隆亮; 藤本裕之; 藤田直尚; 浜松圭太; 原田範雄; 佐賀恒夫; 中本裕士; 稲垣暢也

  日本内科学会雑誌, 2022

  
• Subcutaneous or cutaneous F-18-FDG uptake in the breast co-existing with breast cancer

  Kanae Miyake; Takayoshi Ishimori; Masako Kataoka; Shunsuke Yuge; Tsuneo Saga; Masakazu Toi; Yuji Nakamoto

  JOURNAL OF NUCLEAR MEDICINE, May 2021

  
• Krasトランスジェニックラット膵管がんモデルにおける画像診断の試み(In vivo imaging of pancreatic tumors in transgenic rat model carrying human KrasG12V oncogene)

  柴田 耕治; 佐賀 恒夫; 深町 勝巳; 二口 充; 津田 洋幸; 梛野 正人; 酒々井 眞澄

  日本癌学会総会記事, Oct. 2013

  
• 肝細胞癌切除後予後予測におけるFDG-PETの意義

  波多野 悦朗; 猪飼 伊和夫; 東 達也; 手良向 聡; 鳥塚 達郎; 佐賀 恒夫; 上杉 毅彦; 嶌原 康行

  日本外科学会雑誌, Mar. 2004

  
• 原発性肝癌におけるFDG-PETの有用性

  波多野 悦朗; 猪飼 伊; 東 達也; 手良向 聡; 鳥塚 達郎; 佐賀 恒夫; 上杉 毅彦; 嶌原 康行

  日本消化器病学会雑誌, Mar. 2004

  
• HER3を標的とするZr-89標識抗体によるPETイメージング CTOS移植腫瘍での検討

  元 清華; 古川 高子; 辻 厚至; 永津 弘太郎; 遠藤 洋子; 井上 正宏; 益子 高; 張 明栄; 佐賀 恒夫; 藤林 康久

  核医学, Sep. 2015

  
• HER3を標的とするZr-89標識抗体イメージングの基礎検討

  元 清華; 古川 高子; 金 朝暉; Winn Aung; 吉井 幸恵; 須堯 綾; 永津 弘太郎; 遠藤 洋子; 井上 正宏; 益子 高; 佐賀 恒夫; 藤林 靖久

  JSMI Report, May 2014

  
• 組織型の異なるCTOS移植腫瘍におけるCu-ATSMとFDGの結節内分布比較

  古川 高子; 吉井 幸恵; 元 清華; 遠藤 洋子; 井上 正宏; 藤林 靖久; 佐賀 恒夫

  核医学, Sep. 2013

  
• ヒトの病理組織像を再現するCTOS移植腫瘍におけるCu-ATSMとFDGの結節内分布

  古川 高子; 吉井 幸恵; 元 清華; 遠藤 洋子; 井上 正宏; 藤林 靖久; 佐賀 恒夫

  核医学, Aug. 2012

  
• Insurance Coverage of FDG-PET and Promotion of Clinical PET

  小西 淳二; 佐賀 恒夫; 東 達也

  月刊新医療, Apr. 2002

  
• Promising radiopharmaceuticals in oncological nuclear medicine

  佐賀 恒夫; 石守 崇好; 東 達也

  月刊新医療, Mar. 2001

  
• 粘膜悪性黒色腫におけるFDG PET/CTの検出能と予後予測能

  北口耕輔; 中本裕士; 野橋智美; 子安翔; 三宅可奈江; 石守崇好; 佐賀恒夫

  核医学(Web), 2020

  
• FDG PET/CTによる乳房病変検出における仰臥位と腹臥位の比較

  弓削瞬介; 三宅可奈江; 片岡正子; 大野和子; 石守崇好; 佐賀恒夫; 中本裕士; 川瀬滋人; 戸井雅和

  核医学(Web), 2020

  
• 抗組織因子抗体を用いたグリオーマイメージングと抗体の薬物輸送への応用

  高島 大輝; 安永 正浩; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 原田 充訓; 津村 遼; 安西 高廣; 古賀 宣勝; 黒田 順一郎; 武笠 晃丈; 松村 保広

  JSMI Report, May 2019

  
• Antibody-Drug Conjugate(ADC)開発のためのDDS・分子イメージング

  安永 正浩; 眞鍋 史乃; 辻 厚至; 東 達也; 佐賀 恒夫; 古田 大; 緒方 是嗣; 高島 大輝; 渕上 弥史; 古賀 宣勝; 松村 保広

  JSMI Report, May 2019

  
• Antibody-Drug Conjugate(ADC)開発のためのDDS・分子イメージング

  安永 正浩; 眞鍋 史乃; 辻 厚至; 東 達也; 佐賀 恒夫; 古田 大; 緒方 是嗣; 高島 大輝; 渕上 弥史; 古賀 宣勝; 松村 保広

  JSMI Report, May 2019

  
• 抗組織因子抗体を用いたグリオーマイメージングと抗体の薬物輸送への応用

  高島 大輝; 安永 正浩; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 原田 充訓; 津村 遼; 安西 高廣; 古賀 宣勝; 黒田 順一郎; 武笠 晃丈; 松村 保広

  JSMI Report, May 2019

  
• 線維形成性小円形細胞腫瘍に対するFDG PET/CTの検討

  北口耕輔; 中本裕士; 加藤彩子; 渡部正雄; 木寺英太郎; 尾谷知亮; 弓削瞬介; 子安翔; 三宅可奈江; 石守崇好; 佐賀恒夫; 富樫かおり

  核医学(Web), 2019

  
• 抗組織因子抗体を用いた新規薬物送達システムの開発研究

  高島大輝; 高島大輝; 辻厚至; 佐賀恒夫; 眞鍋史乃; 原田充訓; 津村遼; 安西高廣; 古賀宣勝; 安永正浩; 黒田順一郎; 武笠晃丈; 松村保広

  日本分子脳神経外科学会プログラム・抄録集, 2019

  
• DDS and Molecular Imaging for Antibody-Drug Conjugate (ADC) Development

  安永正浩; 眞鍋史乃; 辻厚至; 東達也; 佐賀恒夫; 古田大; 緒方是嗣; 高島大輝; 渕上弥史; 古賀宣勝; 松村保広

  JSMI Report, 2019

  
• 抗組織因子抗体薬物複合体の悪性グリオーマモデルにおける前臨床試験

  高島大輝; 高島大輝; 眞鍋史乃; 辻厚至; 佐賀恒夫; 津村遼; 安西高廣; 古賀宣勝; 安永正浩; 黒田順一郎; 武笠晃丈; 松村保広

  日本脳腫瘍学会プログラム・抄録集, 2019

  
• 腫瘍性骨軟化症におけるDOTATOC-PET/CTの病変検出力

  中本 裕士; 石守 崇好; 志水 陽一; 佐野 紘平; 佐賀 恒夫; 富樫 かおり

  核医学, Nov. 2018

  
• 免疫抑制に関与するCD73の発現の非侵襲的イメージング(Development of a noninvasive imaging technique to detect the expression of CD73 mediating immunosuppression in cancer)

  須藤 仁美; 辻 厚至; 須堯 綾; 小泉 満; 黒澤 仁; 黒澤 良和; 佐賀 恒夫; 東 達也

  日本癌学会総会記事, Sep. 2018

  
• FMISO-PET imaging may be affected by inhibitors of multidrug-resistant protein 1 independent of the hypoxic state

  Shimizu Y; Nakai Y; Watanabe H; Ono M; Saji H; Kuge Y; Nakamoto Y; Saga T; Togashi K

  The 65nd Society of Nuclear Medicine and Molecular Imaging 2018, Jun. 2018

  
• DDS・分子イメージングを駆使したAntibody‐durg conjugateの開発

  安永正浩; 眞鍋史乃; 辻厚至; 佐賀恒夫; 古田大; 緒方是嗣; 高島大輝; 渕上弥史; 古賀宣勝; 松村保広

  日本DDS学会学術集会プログラム予稿集, 28 May 2018

  
• 膵腫瘤の1例

  WANG Yang; 渡部正雄; 北口耕輔; 中本隆介; 有本麻耶; 三宅可奈江; 石守崇好; 佐賀恒夫; 中本裕士; 富樫かおり

  核医学症例検討会症例集, 2018

  
• 腫瘍性骨軟化症におけるDOTATOC-PET/CTの病変検出力

  中本裕士; 石守崇好; 志水陽一; 佐野紘平; 佐賀恒夫; 富樫かおり

  核医学(Web), 2018

  
• 抗組織因子抗体を用いたグリオーマイメージング

  高島大輝; 高島大輝; 辻厚至; 佐賀恒夫; 安永正浩; 古賀宣勝; 黒田順一郎; 矢野茂敏; 倉津純一; 松村保広

  JSMI Report, 2018

  
• 抗体薬物複合体の研究開発における分子イメージングの有用性

  安永正浩; 眞鍋史乃; 辻厚至; 古田大; 緒方是嗣; 古賀宣勝; 藤原悠起; 佐賀恒夫; 松村保広

  月刊PHARM STAGE, 15 Sep. 2017

  
• The effect of metformin on gut in 18F-FDG PET/CT: comparison with autoradiograph and expression of GLUT-1 and GLUT-2

  Nobashi T; Shimizu Y; Koyasu S; Saga T; Nakamoto Y; Ishimori T; Togashi K

  The 64nd Society of Nuclear Medicine and Molecular Imaging 2017, Jun. 2017

  
• Assessment of 4DST uptake and Ki-67 index in patients with lung tumor in comparison with FDG uptake.

  Ryuichi Nishii; Tsuneo Saga; Hitomi Sudo; Takashi Togawa; Keiichiro Yoshinaga; Tatsuya Higashi

  JOURNAL OF NUCLEAR MEDICINE, May 2017

  
• 抗体-薬物複合体 要素技術と総合技術 分子イメージングを駆使したADCの開発

  安永 正浩; 眞鍋 史乃; 辻 厚至; 古田 大; 緒方 是嗣; 古賀 宣勝; 藤原 悠起; 佐賀 恒夫; 松村 保広

  薬学雑誌, May 2017

  
• Development of ADCs Using Molecular Imaging

  Yasunaga, Masahiro; Manabe, Shino; Tsuji, Atsushi; Furuta, Mamoru; Ogata, Koretsugu; Koga, Yoshikatsu; Fujiwara, Yuki; Saga, Tsuneo; Matsumura, Yasuhiro

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, May 2017, Peer-reviewed

  
• 放射性標識抗Tissue factor抗体を用いた膵癌モデルマウスのイメージング

  辻厚至; 須堯綾; 須藤仁美; 佐賀恒夫; 佐賀恒夫; 小泉満; 安永正浩; 松村保広; 東達也

  核医学(Web), 2017

  
• Development of immuno-PET imaging for refractory cancer

  安永正浩; 辻厚至; 高島大輝; 佐賀恒夫; 松村保広

  JSMI Report, 2017

  
• Molecular imaging using an anti-human tissue factor monoclonal antibody in malignant glioma

  高島大輝; 高島大輝; 辻厚至; 佐賀恒夫; 安永正浩; 古賀宣勝; 黒田順一郎; 矢野茂敏; 倉津純一; 松村保広

  JSMI Report, 2017

  
• 抗組織因子抗体を用いたSPECTによるグリオーマイメージング

  高島 大輝; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 安永 正浩; 渕上 弥史; 古賀 宣勝; 黒田 順一郎; 倉津 純一; 松村 保広

  日本癌学会総会記事, Oct. 2016

  
• 抗組織因子抗体-薬物複合体の悪性グリオーマへの治療応用の可能性とそのコンパニオン診断としての抗体イメージング

  高島 大輝; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 渕上 弥史; 古賀 宣勝; 安永 正浩; 黒田 順一郎; 倉津 純一; 松村 保広

  日本DDS学会学術集会プログラム予稿集, Jun. 2016

  
• 難治性がんに対するantibody-drug conjugate(ADC)の開発

  安永 正浩; 眞鍋 史乃; 辻 厚至; 古田 大; 緒方 是嗣; 高島 大輝; 藤原 悠起; 古賀 宣勝; 佐賀 恒夫; 松村 保広

  日本DDS学会学術集会プログラム予稿集, Jun. 2016

  
• 抗組織因子抗体-薬物複合体の悪性グリオーマへの治療応用の可能性とそのコンパニオン診断としての抗体イメージング

  高島 大輝; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 渕上 弥史; 古賀 宣勝; 安永 正浩; 黒田 順一郎; 倉津 純一; 松村 保広

  日本DDS学会学術集会プログラム予稿集, Jun. 2016

  
• 難治性がんに対するantibody-drug conjugate(ADC)の開発

  安永 正浩; 眞鍋 史乃; 辻 厚至; 古田 大; 緒方 是嗣; 高島 大輝; 藤原 悠起; 古賀 宣勝; 佐賀 恒夫; 松村 保広

  日本DDS学会学術集会プログラム予稿集, Jun. 2016

  
• SPIO‐loaded and cyclic RGD installed polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas

  KAWAMURA Wataru; KAWAMURA Wataru; MIURA Yutaka; KOKURYO Daisuke; AOKI Ichio; KANO Mitsunobu R; NISHIYAMA Nobuhiro; SAGA Tsuneo; KISHIMURA Akihiro; KATAOKA Kazunori; KATAOKA Kazunori

  JSMI Report, 25 Apr. 2016

  
• 分子イメージングを駆使した難治性がんに対するantibody-drug conjugateの開発

  安永 正浩; 眞鍋 史乃; 辻 厚至; 古田 大; 緒方 是嗣; 高島 大輝; 藤原 悠起; 古賀 宣勝; 佐賀 恒夫; 松村 保広

  JSMI Report, Apr. 2016

  
• 分子イメージングを駆使した難治性がんに対するantibody-drug conjugateの開発

  安永 正浩; 眞鍋 史乃; 辻 厚至; 古田 大; 緒方 是嗣; 高島 大輝; 藤原 悠起; 古賀 宣勝; 佐賀 恒夫; 松村 保広

  JSMI Report, Apr. 2016

  
• 温度応答性バイオイメージング分子の合成と物性評価

  荒木健; 村山周平; 唐澤悟; 青木伊知男; 佐賀恒夫; 古賀登

  日本化学会春季年会講演予稿集(CD-ROM), 2016

  
• スマートハイドロゲルによる医薬品モデル化合物放出のイメージング

  村山周平; 河合裕子; 三宅大翔; 嶋田直彦; 佐賀恒夫; 青木伊知男; 丸山厚

  JSMI Report, 2016

  
• 磁気共鳴バイオイメージング用の新規マンガンイオン内包ナノカプセルの物性

  新井和孝; 城潤一郎; 村山周平; 青木伊知男; 佐賀恒夫

  日本化学会春季年会講演予稿集(CD-ROM), 2016

  
• 分子イメージングを駆使したADCの開発

  安永正浩; 眞鍋史乃; 辻厚至; 古田大; 緒方是嗣; 古賀宣勝; 藤原悠起; 佐賀恒夫; 松村保広

  日本薬学会年会要旨集(CD-ROM), 2016

  
• Effective auger electron radioimmunotherapy using modified anti-HER2 antibody with nuclear localizing signal

  Huizi Li; Sumitaka Hasegawa; Tadashi Kamada; Tsuneo Saga

  CANCER RESEARCH, Aug. 2015

  
• Sensitized Cu-64-ATSM internal radiotherapy targeting tumor malignant regions: approach based on its biological characteristics

  Yukie Yoshii; Takako Furukawa; Hiroki Matsumoto; Mitsuyoshi Yoshimoto; Yasushi Kiyono; Ming-Rong Zhang; Yasuhisa Fujibayashi; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2015

  
• Development of drug screening system with nanoimprinting 3D culture to provide effective drugs in vivo and the accompanying PET probes for therapy monitoring

  Yukie Yoshii; Takako Furukawa; Atsuo Waki; Manabu Itoh; Ming-Rong Zhang; Hidekatsu Wakizaka; Yasushi Kiyono; Yasuhisa Fujibayashi; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2015

  
• Synthesis and biological evaluation of 2-amino-2-[C-11]methyl-butanoic acid as a potential PET probe for tumor imaging

  Chie Suzuki; Atsushi B. Tsuji; Koichi Kato; Hitomi Sudo; Ming-Rong Zhang; Yasushi Arano; Tsuneo Saga

  JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, May 2015

  
• Microarray analysis of human breast cancer cells treated with In-111-trastuzumab modified with nuclear localizing signal peptides

  Sumitaka Hasegawa; Huizi Li; Yukie Morokoshi; Takako Furukawa; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2015

  
• γPARCEL:放射線による生体内深部での生理活性物質の機能制御法

  村山周平; 新井和孝; 錦戸文彦; BAKALOVA Rumiana; 加藤大; 佐賀恒夫; 青木伊知男

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 生体イメージングを目指した温度応答性蛍光プローブの合成と水中での物性評価

  荒木健; 嶋田敬志; 村山周平; 唐澤悟; 唐澤悟; 青木伊知男; 佐賀恒夫; 古賀登

  基礎有機化学討論会要旨集, 2015

  
• 温度応答性蛍光イメージングプローブの合成と水中での物性評価

  荒木健; 嶋田敬志; 村山周平; 唐澤悟; 唐澤悟; 青木伊知男; 佐賀恒夫; 古賀登

  日本化学会講演予稿集, 2015

  
• PARCEL~柔らかナノゲルとハードナノゲル~

  村山周平; 城潤一郎; NIKOLOVA Biliana; BAKALOVA Rumiana; 佐賀恒夫; 加藤大; 青木伊知男

  バイオメディカル分析科学シンポジウム講演要旨集, 2015

  
• 放射線応答性ナノ粒子によるタンパク質機能制御

  村山周平; 新井和孝; 錦戸文彦; BAKALOVA Rumiana; 山谷泰賀; 佐賀恒夫; 加藤大; 青木伊知男

  JSMI Report, 2015

  
• Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application

  Yukie Yoshii; Takako Furukawa; Tsuneo Saga; Yasuhisa Fujibayashi

  CANCER LETTERS, Jan. 2015

  
• がん間質の不溶性フィブリンを標的とした腫瘍イメージング(Cancer stromal targeting (CAST) diagnosis using anti-insoluble fibrin Fab antibody)

  生内 寿文; 渕上 弥史; 辻 厚至; 佐賀 恒夫; 安永 正浩; 松村 保広

  日本癌学会総会記事, Sep. 2014

  
• Development of SPIO-loaded Unilamellar Polyion Complex Vesicles (SPIO-Cy5-PICsomes) as a High Relaxivity Contrast Agent for Early-stage Tumor Detection

  KOKURYO DAISUKE; ANRAKU YASUTAKA; KISHIMURA AKIHIRO; TANAKA SAYAKA; KANO MITSUNOBU; NISHIYAMA NOBUHIRO; SAGA TSUNEO; AOKI ICHIO; KATAOKA KAZUNORI

  日本磁気共鳴医学会雑誌, Aug. 2014

  
• 新しい固有同期法を用いた小動物用CTによる左室機能評価

  犬伏正幸; 三輪建太; 青木伊知男; 辻厚至; 竹内康人; 我妻慧; 村田泰輔; 宮原信幸; 佐賀恒夫; 小泉満; 佐々木雅之

  JSMI Rep, 15 May 2014

  
• 新しい固有同期法を用いた小動物用CTによる左室機能評価

  犬伏正幸; 三輪建太; 青木伊知男; 辻厚至; 竹内康人; 我妻慧; 村田泰輔; 宮原信幸; 佐賀恒夫; 小泉満; 佐々木雅之

  JSMI Rep, 15 May 2014

  
• 小動物用SPECT/PET装置を用いた^99mTC/¹⁸F同時収集法の基礎的検討

  三輪建太; 犬伏正幸; 竹内康人; 片渕哲朗; 小泉満; 佐々木雅之; 佐賀恒夫

  JSMI Rep, 15 May 2014

  
• Clinical evaluation of FAZA and FDG-PET/CT for advanced lung cancer patients

  Tsuneo Saga; Masayuki Inubushi; Mitsuru Koizumi; Kyosan Yoshikawa; Ming-Rong Zhang; Atsushi Horiike; Keita Kudo; Fumiyoshi Ohyanagi; Makoto Nishio

  JOURNAL OF NUCLEAR MEDICINE, May 2014

  
• Efficacy of Cu-64-ATSM internal radiotherapy against CD133(+) cancer stem cells in colon carcinoma: Improvement of therapeutic effect with nucleic acid antagonists

  Yukie Yoshii; Takako Furukawa; Hiroki Matsumoto; Mitsuyoshi Yoshimoto; Ming-Rong Zhang; Yasushi Kiyono; Hiroshi Yoshii; Yasuhisa Fujibayashi; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2014

  
• Simultaneous PET/SPECT imaging to compare tumor uptake level of 18F-FMISO with 64Cu-ATSM on the basis of the genetic activation level responding to tumor hypoxia

  Yasuto Takeuchi; Masayuki Inubushi; Yong-Nan Jin; Kotaro Nagatsu; Chika Murai; Atsushi Tsuji; Hironobu Hata; Yoshimasa Kitagawa; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2014

  
• MRI造影剤を含む高分子ミセルと生分解性ゲルを用いた脳内薬剤投与法の検討

  國領 大介; Mi Peng; 栗田 朋香; 谷田部 輝幸; Cabral Horacio; 柴田 さやか; 岡本 沙織; 村垣 善浩; 伊関 洋; 酒井 崇匡; 鄭 雄一; 西山 伸宏; 佐賀 恒夫; 青木 伊知男; 片岡 一則

  JSMI Report, May 2014

  
• 生体ケイ光プローブとしてのTFMAQ誘導体の応用

  嶋田敬志; 唐澤悟; 藤本景子; 田中嘉孝; 古賀登; 村山周平; 佐賀恒夫; 青木伊知男

  基礎有機化学討論会要旨集, 2014

  
• デュアルプローブ包含ソフトナノゲル

  村山周平; 村山周平; 城潤一郎; 柴田悠圭; 三田智文; 佐賀恒夫; 青木伊知男; 加藤大

  JSMI Report, 2014

  
• ソフトナノ粒子を用いたデュアルプローブ

  村山周平; 村山周平; 城潤一郎; 柴田悠圭; LIANG Kun; 三田智文; 佐賀恒夫; 青木伊知男; 加藤大

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 抗フィブリン抗体を用いた腫瘍イメージング

  生内寿文; 生内寿文; 渕上弥史; 渕上弥史; 辻厚至; 佐賀恒夫; 安永正浩; 松村保広; 松村保広

  日本DDS学会学術集会プログラム予稿集, 2014

  
• がん間質を標的としたフィブリンクロットに対する新規特異抗体の開発(Development of novel anti-fibrin clot specific antibody for cancer stromal targeting therapy and diagnosis)

  久田 洋平; 安永 正浩; 杉野 隆; 佐賀 恒夫; 眞鍋 史乃; 黒田 順一郎; 倉津 純一; 松村 保広

  日本癌学会総会記事, Oct. 2013

  
• 抗フィブリンFabフラグメントによる腫瘍の生体イメージング(Tumor imaging with fibrin-specific-binding Fab fragments)

  生内 寿文; 渕上 弥史; 久田 洋平; 津村 遼; 佐賀 恒夫; 安永 正浩; 松村 保広

  日本癌学会総会記事, Oct. 2013

  
• ポジトロン用マルチピンホールコリメータの^99mTcに対する性能評価

  三輪建太; 犬伏正幸; 竹内康人; 片渕哲朗; 小泉満; 佐賀恒夫; 佐々木雅之

  核医学, 30 Sep. 2013

  
• 90Y標識抗トランスフェリン受容体抗体の膵癌モデルマウスにおける治療効果の評価

  須堯 綾; 辻 厚至; 須藤 仁美; 鵜飼 由範; 黒澤 仁; 黒澤 良和; 佐賀 恒夫

  核医学, Sep. 2013

  
• がん間質を標的とした抗不溶性フィブリン特異抗体102-10の機能解析

  久田 洋平; 安永 正浩; 花岡 慎悟; 西條 信史; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 松村 保広

  日本DDS学会学術集会プログラム予稿集, Jun. 2013

  
• 超常磁性酸化鉄微粒子を内包したポリイオンコンプレックス型中空粒子SPIO‐PICsomeの開発と緩和能・腫瘍集積性評価

  國領大介; 安楽泰孝; 岸村顕広; 田中さやか; 狩野光伸; 西山伸宏; 佐賀恒夫; 青木伊知男; 片岡一則

  JSMI Rep, May 2013

  
• 高分子造影剤による組織再生の磁気共鳴イメージング

  JO JUN'ICHIRO; AOKI ICHIO; YAMAMOTO MASAYA; SAGA TSUNEO; TABATA YASUHIKO

  再生医療, 28 Feb. 2013

  
• フィブリンを標的にしたCAST(Cancer Stroma targeting)診断治療法の開発(Development of fibrin-targeting CAST (Cancer stroma targeting) diagnosis and therapy)

  安永 正浩; 杉野 隆; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 松村 保広

  日本癌学会総会記事, Aug. 2012

  
• CAST(Cancer stroma targeting)診断治療法の開発(異分野連携とイメージングテクノロジーを駆使した新規抗間質抗体開発戦略)

  安永 正浩; 辻 厚至; 杉野 隆; 佐賀 恒夫; 眞鍋 史乃; 松村 保広

  バイオイメージング, Aug. 2012

  
• 超常磁性酸化鉄微粒子を内包したポリイオンコンプレックス型中空ナノ粒子PICsomeを用いたin vivo MRイメージング

  國領大介; 安楽泰孝; 岸村顕広; 田中さやか; 狩野光伸; 佐賀恒夫; 片岡一則; 青木伊知男

  日本DDS学会学術集会プログラム予稿集, 05 Jun. 2012

  
• 抗フィブリン抗体を用いたCancer Stroma targeting(CAST)診断法の開発

  安永 正浩; 杉野 隆; 辻 厚至; 佐賀 恒夫; 眞鍋 史乃; 松村 保広

  日本DDS学会学術集会プログラム予稿集, Jun. 2012

  
• Molecular genetic imaging of hypoxia response using sodium/iodide symporter (NIS) reporter gene

  Yasuto Takeuchi; Masayuki Inubushi; Hua Xu; Keiko Mio; Hironobu Hata; Yoshimasa Kitagawa; Tsuneo Saga

  JOURNAL OF NUCLEAR MEDICINE, May 2012

  
• フィブリンを標的にしたPET・CTイメージングとがん診断への応用

  安永 正浩; 辻 厚至; 杉野 隆; 佐賀 恒夫; 眞鍋 史乃; 松村 保広

  JSMI Report, May 2012

  
• 高分子造影剤を用いた血管新生治療の磁気共鳴 イメージング

  城潤一郎; 林雪; 中原鉄平; 青木伊知男; 佐賀恒夫; 田畑泰彦

  第7 回日本分子イメージング学会学術集会（2012.5.24－25．浜松）, 2012, Peer-reviewed

  
• フラクタル次元を用いた肺癌と炎症性疾患の鑑別

  三輪建太; 我妻慧; 小山眞道; 犬伏正幸; 佐賀恒夫; 長尾充展; 佐々木雅之

  核医学, 30 Sep. 2011

  
• Assessment of C-11-2-Aminoisobutyric Acid in Nude Mice with Tumor and Inflammation

  Atsushi B. Tsuji; Koichi Kato; Aya Sugyo; Hitomi Sudo; Chisato Yoshida; Ming-Rong Zhang; Saga Tsuneo

  JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2011

  
• The role of FDG-PET in pediatric Non-Hodgkin lymphoma

  K. Nakatani; Y. Nakamoto; T. Suga; K. K. Miyake; K. Kurihara; T. Saga; T. Higashi; K. Togashi

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Oct. 2010

  
• Molecular MR Imaging of Cancer Gene Therapy: Ferritin Transgene Reporter Takes the Stage

  Sumitaka Hasegawa; Takako Furukawa; Tsuneo Saga

  MAGNETIC RESONANCE IN MEDICAL SCIENCES, 2010

  
• PETによるがん診断 -FDG以外のPETプローブ

  佐賀 恒夫; 吉川 京燦; 岡沢 秀彦

  日本医事新報, 2010

  
• Comparison of diagnostic performance between MR with diffusion-weighted imaging and FDG-PET for recurrent ovarian cancer

  Y. Nakamoto; T. Saga; K. Tamai; K. Hayashida; K. Togashi

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Sep. 2009

  
• Comparison of Glucose metabolism measured by FDG-PET/CT and Cellularity obtained from MRI for malignancy evaluation of pancreatic tumor

  K. Tanimoto; K. Yoshikawa; T. Obata; S. Toubaru; S. Ohashi; M. Hasebe; T. Shiraishi; K. Watanabe; T. Saga; H. Ikehira; J. Mizoe; T. Kamada; H. Tsujii; A. Kato; M. Miyazaki

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Sep. 2009

  
• Molecular imaging of cancer-evaluating characters of individual cancer by PET/SPECT imaging

  Tsuneo Saga; Mitsuru Koizumi; Takako Furukawa; Kyosan Yoshikawa; Yasuhisa Fujibayashi

  CANCER SCIENCE, Mar. 2009

  
• Noninvasive F-18-FDG Positron Emission Tomography Provides Window into Cellular Properties of Rejection after Liver Transplantation.

  Miwa Morita; Atsushi B. Tsuji; Shizuko Nagao; Shiro Takahara; Atsushi Sugioka; Mitsuru Koizumi; Tsuneo Saga; Xiao-Kang Li

  AMERICAN JOURNAL OF TRANSPLANTATION, 2009

  
• Gastric cancer found on 3 '-deoxy-3 ' F-18 fluorothymidine positron emission tomography

  Mitsuru Koizumi; Tsuneo Saga; Kyosan Yoshikawa; Masayuki Baba

  CLINICAL NUCLEAR MEDICINE, Sep. 2008

  
• Diagnostic performance of CT, PET, side-by-side, and fused image interpretations for restaging of non-Hodgkin lymphoma

  Munenobu Nogami; Yuji Nakamoto; Setsu Sakamoto; Kazuto Fukushima; Tomohisa Okada; Tsuneo Saga; Tatsuya Higashi; Michio Senda; Toshimitsu Matsui; Kazuro Sugimura

  Annals of Nuclear Medicine, Jun. 2007

  
• 子宮筋層病変の拡散強調画像

  玉井 賢; 小山 貴; 木戸 晶; 梅岡 成章; 藤原 俊孝; 片岡 正子; 佐賀 恒夫; 富樫 かおり

  Radiation Medicine, 25 Apr. 2007

  
• 転移性卵巣腫ようの臨床およびMR画像所見

  小山貴; 玉井賢; 梅岡成章; 片岡正子; 佐賀恒夫; 藤井信吾; 富樫かおり

  日本医学放射線学会学術集会抄録集, 25 Feb. 2006

  
• 3.0TでのMRCP画像 健常ボランティアにおける予備的経験(MRCP imaging at 3.0T: Preliminary Experience in Healthy Volunteers)

  磯田 裕義; 片岡 正子; 前谷 洋爾; 玉井 賢; 梅岡 成章; 木戸 晶; 小山 貴; 中本 裕士; 佐賀 恒夫; 富樫 かおり

  日本医学放射線学会学術集会抄録集, Feb. 2006

  
• FLT‐PETによる原発性脳腫ようの診断:その有用性と限界

  佐賀恒夫; 東達也; 石津浩一; 河嶋秀和; 向高弘; 大屋夏生; 永田靖; 荒木則雄; 平岡真寛

  日本医学放射線学会学術集会抄録集, 25 Feb. 2005

  
• 子宮筋層病変の鑑別における拡散強調画像(ADC値)の有用性の検討

  玉井 賢; 小山 貴; 木戸 晶; 梅岡 成章; 藤原 俊孝; 片岡 正子; 佐賀 恒夫; 富樫 かおり

  日本医学放射線学会学術集会抄録集, 25 Feb. 2005

  
• CTによる子宮体癌の術前リンパ節転移の診断能

  森澤 信子; 小山 貴; 玉井 賢; 梅岡 成章; 木戸 晶; 片岡 正子; 佐賀 恒夫; 伊藤 剛; 富樫 かおり

  日本医学放射線学会学術集会抄録集, 25 Feb. 2005

  
• 脳内ニコチン作動性ACh受容体の禁煙による変化:¹²³I‐5IA SPECTによる検討

  石津浩一; MAMEDE M; 上田真史; 河嶋秀和; 向高弘; 佐賀恒夫; 佐治英郎; 富樫かおり

  核医学, 20 Nov. 2004

  
• Prognostic value of dual-phase FDG PET in patients with pancreatic cancer

  A Lyshchik; T Higashi; Y Nakamoto; K Fujimoto; R Doi; M Imamura; T Saga

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Aug. 2004

  
• Pancreatic Endocrine Tumor in Japan

  Ryuichiro Doi; Izumi Komoto; Yoshio Nakamura; Junichiro Kawamura; Koji Fujimoto; Michihiko Wada; Tsuneo Saga; Masayuki Imamura

  Pancreas, Apr. 2004

  
• 前立腺癌の診断における拡散強調画像の有用性;病理的悪性度との対比

  小山貴; 藤原俊孝; 梅岡成章; 清川岳彦; 賀本敏行; 小川修; 小谷泰一; 佐賀恒夫; 富樫かおり

  日本磁気共鳴医学会雑誌, 2004

  
• PET ¹⁵O Gas Steady State法:計測精度向上のための工夫

  石津浩一; 秋田行朗; 向高弘; 北野治広; 佐賀恒夫

  核医学, 20 Nov. 2003

  
• Usefulness and limitation of FDG PET in detection of small pancreatic cancers 20mm in diameter or smaller.

  T Higashi; T Saga; T Ishimori; M Mamede; K Ishizu; T Fujita; T Mukai; K Fujimoto; R Doi; M Imamura

  JOURNAL OF NUCLEAR MEDICINE, May 2003

  
• Prediction of short-term prognosis by FDG-PET in patients after surgery for colorectal cancer.

  Y Nakamoto; T Saga; T Higashi; T Ishimori; M Mamede; K Ishizu; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2003

  
• Evaluation of therapeutic effect in patients of advanced pancreatic cancer using FDG PET.

  T Higashi; T Saga; T Ishimori; M Mamede; K Ishizu; T Fujita; T Mukai; K Fujimoto; R Doi; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2003

  
• Evaluation of positron intra-operative probe using F-18FDG in preoperative cancer patients.

  T Higashi; T Saga; S Yamamoto; T Ishimori; M Mamede; K Ishizu; T Fujita; T Mukai; K Matsumoto; M Senda

  JOURNAL OF NUCLEAR MEDICINE, May 2003

  
• Clinical value of FDG-PET in the follow up of post-operative patients with endometrial cancer.

  T Saga; T Higashi; T Ishimori; M Mamede; Y Nakamoto; T Mukai; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2003

  
• 加速するPET導入と核医学 核医学の最新動向と展望

  東達也; 佐賀恒夫; 石津浩一; 多田村栄二; 向高弘; 小西淳二

  月刊新医療, 01 Mar. 2003

  
• 食道癌におけるFDG-PET検査の有用性と医療経済学的効果．―アンケート調査の集計結果などに基づいた検討―

  新井清和; 加藤広行; 井上登美夫; 桑野博行; 織内 昇; 東 達也; 佐賀恒夫; 玉木長良; 佐々木雅之; 桑原康雄; 山田里奈; 川渕孝一; 遠藤啓吾

  RADIOISOTOPES, 2003

  
• Radiolabeling of Avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.

  M Mamede; T Saga; T Ishimori; T Higashi; H Kobayashi; J Konishi; MW Brechbiel

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• Comparison of F-18-FDG PET, whole body Tc-99m-sestamibi spect and I-131 scintigraphy in netastatic differentiated thyroid cancer.

  M Iwata; K Kasagi; T Misaki; K Matsumoto; Y Iida; T Ishimori; Y Nakamoto; T Higashi; T Saga; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• Diagnostic value of F-18-FDG PET in patients with cystic pancreatic tumors, including intraductal papillary mucinous tumor (IPMT).

  T Higashi; T Saga; T Ishimori; MH Mamede; Y Maetani; K Ito; K Okazaki; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• The use of attenuation correction (AC) is critical for beginner PET-oncologist in the diagnosis of abdominal and pelvic tumors by F-18-FDG PET.

  T Higashi; Y Nakamoto; T Saga; T Ishimori; MH Mamede; K Ishizu; E Tadamura; K Matsumoto; T Mukai; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• Relationship between retention index (RI) in dual-phase F-18-FDG PET and prognosis in pancreatic cancers.

  T Higashi; T Saga; Y Nakamoto; T Ishimori; MH Mamede; T Fujita; T Mukai; R Doi; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• FDG uptake, GLUT-1 and hexokinase-II expression in lung cancers and inflammatory lesions of the lung.

  M Mamede; T Higashi; T Saga; T Ishimori; K Yanagihara; M Li; F Tanaka; H Wada; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• Rapid accumulation of radiolabeled herceptin in an inflammatory breast cancer xenograft with an new type of vasculogenesis "vasculogenic mimicry", which is advantageous for radioimmunotherapy.

  H Kobayashi; K Shirakawa; S Kawamoto; T Saga; K Togashi; J Konishi; MW Brechbiel; TA Waldmann; H Wakasugi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• F-18-FDG-PET for evaluation of the treatment response of lung cancer after stereotactic radiotherapy.

  T Ishimori; T Saga; T Higashi; M Mamede; Y Nakamoto; Y Nagata; M Hiraoka; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• Dynamic micro-MRI of liver micrometastasis in the mice with a novel liver MRI contrast agent: DAB-Am64-(1B4M-Gd)64

  H Kobayashi; T Saga; S Kawamoto; J Konishi; K Togashi; MW Brechbiel

  RADIOLOGY, Nov. 2001

  
• Clinical contribution of FDG-PET in the diagnosis, staging and management of pancreatic carcinoma

  東 達也; 佐賀 恒夫; 小西 淳二

  外科治療 = Surgical therapy : 外科系臨床雑誌, Jun. 2001

  
• Multivariate analysis of FDG uptake in human pancreatic cancers: Prognosis, GLUT-1 glucose transporter and tumor cellularity.

  T Higashi; T Saga; Y Nakamoto; T Ishimori; MH Mamede; R Doi; R Hosotani; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Optimal scan time for evaluating suspected pancreatic cancer with FDG-PET.

  Y Nakamoto; T Saga; T Higashi; T Ishimori; H Kobayashi; K Ishizu; H Sakahara; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Relationship between retention index (RI) in two-phased FDG-PET and hexokinase-II and glucose transporter-1 expression in pancreatic cancers.

  T Higashi; Y Nakamoto; T Saga; T Ishimori; MH Mamede; R Doi; R Hosotani; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Additional value of FDG-PET in evaluating follow-up patients with esophageal cancer.

  Y Nakamoto; T Saga; T Ishimori; T Higashi; M Mamede; M Imamura; H Sakahara; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Differential uptake of F-18-FDG in experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of steroid pretreatment on tumor uptake.

  M Mamede; T Saga; T Ishimori; Y Nakamoto; H Kobayashi; N Sato; T Higashi; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Clinical impact of attenuation correction (AC) in the diagnosis of abdominal and pelvic tumors by FDG-PET with ordered subsets expectation maximization (OSEM) reconstruction.

  T Higashi; T Saga; Y Nakamoto; T Ishimori; MH Mamede; K Ishizu; E Tadamura; K Matsumoto; T Fujita; T Mukai; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Clinical follow up of patients with gynecological malignancies who underwent FDG-PET without imaging evidence of recurrence.

  T Saga; T Ishimori; Y Nakamoto; T Higashi; M Mamede; T Higuchi; M Kita; S Fujii; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Comparison of F-18-FDG and C-11-methionine PET for evaluation of the treatment response of lung cancer after stereotactic radiotherapy.

  T Ishimori; T Saga; T Higashi; Y Nakamoto; MH Mamede; Y Nagata; M Hiraoka; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• Synthesis and pharmacokinetics of a novel tumor-targeting and internalizing therapeutic agent, Avidin-dendrimer-1B4M(X), to deliver radiometals emitting Auger electrons into the cell.

  H Kobayashi; T Saga; S Kawamoto; N Sato; T Ishimori; TL Haque; MH Mamede; J Konishi; K Togashi; MW Brechbiel

  JOURNAL OF NUCLEAR MEDICINE, May 2001

  
• FDG-PET of autoimmune-related pancreatitis: preliminary results

  Y Nakamoto; T Saga; T Ishimori; T Higashi; M Mamede; K Okazaki; M Imamura; H Sakahara; J Konishi

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Dec. 2000

  
• 3D-micro MR angiography of intratumoral microvasculature in experimental tumor models using a novel macromolecular MR contrast agent with generation-6 polyamidoamine dendrimer core

  H Kobayashi; N Sato; T Saga; J Konishi; K Togashi; MW Brechbiel

  RADIOLOGY, Nov. 2000

  
• Intraperitoneal tumor targeting of DNA complexed with polyamidoamine dendrimers or avidin and its imaging in mice.

  N Sato; H Kobayashi; T Saga; Y Nakamoto; T Ishimori; MW Brechbiel; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2000

  
• High FDG uptake in autoimmune chronic pancreatitis.

  Y Nakamoto; T Saga; T Ishimori; H Sakahara; T Higashi; K Okazaki; M Imamura; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2000

  
• Clinical contribution of FDG-PET for follow-up patients with gynecological malignancies.

  Y Nakamoto; T Saga; T Ishimori; K Togashi; T Higuchi; S Fujii; H Sakahara; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2000

  
• Enhanced therapeutic effect of radioimmunotherapy by the combination of whole-body mild hyperthermia.

  T Saga; H Sakahara; Y Nakamoto; N Sato; T Ishimori; M Kuroki; S Masunaga; K Sasai; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 2000

  
• Autoimmune pancreatitis with F-18 fluoro-2-deoxy-D-glucose PET findings

  Y Nakamoto; H Sakahara; T Higashi; T Saga; N Sato; K Okazaki; M Imamura; J Konishi

  CLINICAL NUCLEAR MEDICINE, Oct. 1999

  
• Establishment and characterization of a breast cancer cell line stably expressing sodium iodide symporters for novel cancer treatment

  Y Nakamoto; H Sakahara; T Saga; N Sato; T Misaki; S Kosugi; J Konishi

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Sep. 1999

  
• Reduction of side effects by avidin chase in the radioimmunotherapy for experimental liver micrometastases.

  N Sato; T Saga; H Sakahara; Y Nakamoto; M Kuroki; Y Iida; K Endo; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1999

  
• Avidin-biotin system for delivery of diagnostic agents

  H Sakahara; T Saga

  ADVANCED DRUG DELIVERY REVIEWS, May 1999

  
• The effect of glycosylation and isoelectric point on tumor accumulation of avidin.

  M Zhang; Z Yao; H Sakahara; T Saga; T Higashi; Y Nakamoto; N Sato; S Zhao; Y Arano; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1998

  
• Rapid internalization of avidin after binding to tumor cells.

  Z Yao; M Zhang; H Sakahara; T Saga; Y Nakamoto; N Sato; S Zhao; Y Arano; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1998

  
• A novel technique of immunoscintigraphy using metabolizable linker together with angiotensin II treatment.

  Y Nakamoto; T Saga; H Sakahara; Z Yao; M Zhang; N Sato; S Zhao; Y Fujioka; Y Arano; H Saji; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1998

  
• Improved intratumoral penetration of radiolabeled streptavidin in intrapentoneal tumors pretargeted with biotinylated antibody

  Meili Zhang; Zhengsheng Yao; Tsuneo Saga; Harumi Sakahara; Yuji Nakamoto; Noriko Sato; Hiroshi Nakada; Ikuo Yamashina; Junji Konishi

  Journal of Nuclear Medicine, Jan. 1998

  
• Technetium-99m (V)-dimercaptosuccinic acid: normal accumulation in the breasts

  Y Nakamoto; H Sakahara; H Kobayashi; T Saga; N Tsuboyama; T Nakamura; J Konishi

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Sep. 1997

  
• Transient hypersecretion of catecholamines associated with exacerbation of symptoms after I-131 MIBG therapy in patients with pheochromocytoma.

  H Sakahara; T Saga; Z Yao; Y Nakamoto; N Sato; M Hosono; K Endo; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1997

  
• Radioimmunotherapy of experimental liver micrometastases with iodine-131 labeled anti-CEA monoclonal antibody.

  T Saga; N Sato; H Sakahara; Z Yao; Y Nakamoto; M Zhang; S Zhao; M Kuroki; Y Matsuoka; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1997

  
• Radiotherapy of intraperitoneal tumor with I-131 labeled avidin.

  M Zhang; Z Yao; H Sakahara; Y Arano; K Wakisaka; T Saga; Y Nakamoto; N Sato; S Zhao; H Saji; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1997

  
• Improved intratumoral penetration of radiolabeled streptavidin in intraperitoneal tumor pretargeted with biotinylated antibody.

  Z Yao; M Zhang; T Saga; H Sakahara; Y Nakamoto; N Sato; S Zhao; H Nakada; Yamashina, I; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1997

  
• Radiotherapy of malignant ascites with In-111 labeled avidin

  Z Yao; M Zhang; H Sakahara; T Saga; Y Nakamoto; N Sato; S Zhao; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1997

  
• Imaging of intraperitoneal tumor with Tc-99m GSA.

  Z Yao; M Zhang; H Sakahara; T Saga; Y Nakamoto; N Sato; S Zhao; Y Arano; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1997

  
• Anti-murine antibody response to mouse monoclonal antibodies in cancer patients

  Harumi Sakahara; Tsuneo Saga; Hisashi Onodera; Zhengsheng Yao; Yuji Nakamoto; Meili Zhang; Noriko Sato; Hiroshi Nakada; Ikuo Yamashina; Keigo Endo; Junji Konishi

  Japanese Journal of Cancer Research, 1997

  
• Intravenous avidin chase improved localization of radiolabeled streptavidin in intraperitoneal xenograft pretargeted with biotinylated antibody

  Meili Zhang; Harumi Sakahara; Zhengsheng Yao; Tsuneo Saga; Yuji Nakamoto; Noriko Sato; Hiroshi Nakada; Ikuo Yamashina; Junji Konishi

  Nuclear Medicine and Biology, 1997

  
• Targeting of xenografted intraperitoneal tumor using antibody-avidin conjugate and radiolabeled biotin.

  M Zhang; H Sakahara; Z Yao; T Saga; M Nakayama; Y Nakamoto; H Nakada; Yamashima, I; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1996

  
• Two-step targeting of xenografted tumors with conjugate of streptavidin and antibody fragment.

  Z Yao; H Sakahara; M Zhang; T Saga; H Kobayashi; Y Nakamoto; S Toyama; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1996

  
• Targeting of xenografted intraperitoneal tumor using antibody-avidin conjugate and radiolabeled biotin.

  M Zhang; H Sakahara; Z Yao; T Saga; M Nakayama; Y Nakamoto; H Nakada; Yamashima, I; J Konishi

  JOURNAL OF NUCLEAR MEDICINE, May 1996

  
• Effect of drugs on malignant cells studied by 1H MRS.

  伊島理枝子; 赤坂一之; 中井敏晴; 遠藤啓吾; 細野真; 佐賀恒夫; 阪原晴海; 小西淳二

  NMR討論会講演要旨集, Oct. 1991

  
• Fundamental and clinical studies of the measurement of serum CA 19-9 concentrations in patients with pancreatic and gastrointestinal cancer using (Ball CA 19-9 kits).

  HOSONO MAKOTO; ENDO KEIGO; NAKAJIMA KOTOKO; NAKAI TOSHIHARU; SAGA TSUNEO; SAKAHARA HARUMI; KONISHI JUNJI; MANABE TADAO; TOBE RYUKICHI

  月刊医学と薬学, Jan. 1991

  
• Antigenic nature in a care who showed remarkably high serum CA 125 and normal CA 130 levels.

  中西雅子; 遠藤啓吾; 佐賀恒夫; 小野山靖人; 細野真; 中井敏晴; 渡辺祐司; 阪原晴海; 小西淳二; 小林久隆; 藤井信吾; 森崇英

  医学と薬学, Jun. 1990

  
• Basic and clinical studies on ELSA CA 72-4 kit for measurement of serum CA 72-4 concentrations: Usefulness in patients with gastrointestinal cancer

  Toshiharu Nakai; Keigo Endo; Tetsuo Nakashima; Noriko Hattori; Makoto Hosono; Tsuneo Saga; Yuji Watanabe; Harumi Sakahara; Junji Konishi; Takayoshi Tobe

  核医学, May 1990

  
• Therapy of Malignant Pheochromocytoma Using I-131 Metaiodobenzylguanidine -Report of a Case-

  Goto Kimiko; Abe Mitsuyuki; Konishi Junji; Kasagi Kanji; Nakai Toshiharu; Watanabe Yuji; Saga Tsuneo; Endo Keigo; Okazawa Hidehiko; Matsunaga Masato; Kawai Chuichi; Murakami Tomoyuki; Nakao Kazuwa

  日本医学放射線学会雑誌, 25 Mar. 1990

  
• Basic and clinical studies on SPan-1 RIABEAD kit: Usefulness in patients wiith pancreatic and biliary tract cancer.

  渡辺祐司; 遠藤啓吾; 中島言子; 服部典子; 阪原晴海; 佐賀恒夫; 中井敏晴; 細野 真; 姚 正生; 馬場信夫; 大塩学而; 真鍋忠夫; 戸部隆吉

  核医学, Dec. 1989

  
• 腫瘍関連糖蛋白CA72測定用キット'CENTOCOR CA72-4 RIA'の基礎的並びに臨床的検討

  渡辺祐司; 遠藤啓吾; 中島言子; 小泉満; 中井敏晴; 佐賀恒夫; 河村泰孝; 小西 淳二; 真鍋忠夫; 戸部隆吉

  基礎と臨床, 1988

  

Presentations

• Assessment of 4DST uptake and Ki-67 index in patients with lung tumor in comparison with FDG uptake.

  Nishii R; Saga T; Sudo H; Togawa T; Yoshinaga K; Higashi T

  64th Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Jun. 2017

  
• The effect of metformin on gut in 18F-FDG PET/CT: comparison with autoradiograph and expression of GLUT-1 and GLIT-2.

  Nobashi T; Shimizu Y; Koyasu S; Saga T; Nakamoto Y; Ishimori T; Togashi K

  64th Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Jun. 2017

  
• Molecular Imaging and Therapy Targeting Hypoxic Microenvironment.

  SAGA Tsuneo

  Northeatsern Asian Conference on Molecular Imaging-based Precision Medicine (2016), 11 Nov. 2016, Invited

  
• 低酸素PETによる難治がん診断

  佐賀 恒夫

  第56回日本核医学会学術総会, 03 Nov. 2016

  
• 64Cu-ATSM internal radiotherapy to treat colon cancer acquiring resistance to antiangiogenic therapy with bevacizumab.

  Yoshii Y; Furukawa T; Yoshimoto M; Matsumoto H; Zhang MR; Inubushi M; Fujibayashi Y; Saga T

  The 63rd Annual Meeting of the Society of Nuclear Meicine and Molecular Imaging, Jun. 2016

  
• Effect of TSH, FT3 and FT4 on brown adipose tissue visualization of clinical FDG-PET/CT.

  Nishii R; Nagamachi S; Mizutani Y; Higashi T; Yoshinaga K; Saga T

  The 63rd Annual Meeting of the Society of Nuclear Meicine and Molecular Imaging, Jun. 2016

  
• がん新生血管と低酸素を標的とするプローブ開発と放射線内用療法への応用

  佐賀 恒夫

  日本分子イメージング学会 第11回総会・学術集会, 28 May 2016

  
• Evaluation of simultaneous dual-isotope SPECT/PET/CT imaging with 99mTc and 64Cu by phantom study and its in vivo application.

  Adachi N; Yoshii Y; Furukawa T; Takeuchi Y; Inubushi M; Wakizaka H; Zhang MR; Fujibayashi Y; Saga T

  2015 International Chemical Congress of Pacific Basin Societies, Dec. 2015

  
• Selection of effective adjuvant therapy agent for colon cancer with a novel 3D culture screening system: Evaluation with molecular imaging technique.

  Yoshii Y; Furukawa T; Aoyama H; Adachi N; Zhang MR; Wakizaka H; Fujibayashi Y; Saga T

  2015 International Chemical Congress of Pacific Basin Societies, Dec. 2015

  
• Theranostic application of cancer targeting probes labeled with various copper radioisotopes.

  SAGA Tsuneo

  2015 International Chemical Congress of Pacific Basin Societies, Dec. 2015, Invited

  
• 腫瘍の分子イメージング：FDG以外の分子プローブの応用

  佐賀 恒夫

  第55回日本核医学会学術総会, Nov. 2015

  
• Clinical value of FAZA-PET/CT in Head and Neck Cancer Patients.

  Saga T; Inubushi M; Koizumi M; Yoshikawa K; Zhang M; Obata T; Harada R; Uno T

  Annual Congress of European Association of Nuclear Medicine 2015, Oct. 2015

  
• Targeted Imaging and Therapy of Cancer with Molecular Probes Labeled with Copper Radioisotopes.

  SAGA Tsuneo

  The 11th Hangzhou International Molecular Imaging Conference, 19 Sep. 2015, Invited

  
• Comparison of tumor uptake of the radiotracers targeting cancer metabolism.

  Furukawa T; Yuan Q; Jin ZH; Aung W; Saga T

  World Molecular Imaging Congress 2015, Sep. 2015

  
• Clinical value of FAZA-PET/CT in advanced lung cancer patients: comparison with FDG-PET/CT.

  Saga T; Inubushi M; Koizumi M; Yoshikawa K; Zhang MR; Horiike A; Yanagitani N; Ohyanagi F; Nishio M

  World Molecular Imaging Congress 2015, Sep. 2015

  
• Study for single and fractionated radioimmunotherapy (RIT) of 90Y-labeled anti-64 integrin antibody in pancreatic cancer model.

  Aung W; Tsuji AB; Sudo H; Sugyo A; Ukai Y; Kouda K; Kurosawa Y; Furukawa T; Saga T

  World Molecular Imaging Congress 2015, Sep. 2015

  
• Labeling and stability studies for a tetrameric cyclic RGD peptide based radiopharmaceutical 64/67Cu-cyclam-RAFT-c(-RGDfL-)4.

  Jin ZH; Furukawa T; Degardin M; Boturyn D; Zhang MR; Fujibayashi Y; Dumy P; Saga T

  World Molecular Imaging Congress 2015, Sep. 2015

  
• Microarray analysis of human breast cancer cells treated with 111In-trastuzumab modified with nuclear localizing signal peptides.

  Hasegawa S; Li H; Morokoshi Y; Furukawa T; Saga T

  The 62nd Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Jun. 2015

  
• Sensitized 64Cu-ATSM internal radiotherapy targeting tumor malignant regions: approach based on its biological characteristics.

  Yoshii Y; Furukawa T; Matsumoto H; Yoshimoto M; Kiyono Y; Zhang M-R; Fujibayashi Y; Saga T

  The 62nd Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Jun. 2015

  
• Development of drug screening system with nanoimprinting 3D culture to provide effective drugs in vivo and the accompanying PET probes for therapy monitoring.

  Yoshii Y; Furukawa T; Waki A; Itoh M; Zhang M-R; Wakizaka H; Kiyono Y; Fujibayashi Y; Saga T

  The 62nd Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Jun. 2015

  
• Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET.

  Miwa K; Inubushi M; Takeuchi Y; Katafuchi T; Koizumi M; Saga T; Sasaki M

  The 62nd Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Jun. 2015

  
• Molecular imaging of cancer hypoxia and development of internal radiotherapy targeting hypoxic microenvironment.

  SAGA Tsuneo

  ICRR2015 15th International Congress of Radiation Research, 26 May 2015

  
• がん新生血管と低酸素を標的とするPETプローブ開発と放射線内用療法への応用

  佐賀 恒夫

  第74回日本医学放射線学会総会, Apr. 2015

  
• PET imaging of cancer hypoxia and development of internal radiotherapy targeting hypoxic microenvironment.

  SAGA Tsuneo

  NSFC-CAS-JSPS International Workshop on Frontier of Science and Technology 2014 Frontier of Translational Medicine: Molecular Imaging, 06 Dec. 2014, Invited

  
• 重粒子線治療とPETイメージング

  佐賀 恒夫

  第54回日本核医学会学術総会, Nov. 2014

  
• ナノバイオテクノロジーと生体イメージング

  佐賀 恒夫

  第16回ヒューマンサイエンス総合研究ワークショップ, Dec. 2013

  
• 低酸素イメージング

  佐賀 恒夫

  第53回日本核医学会学術総会, Nov. 2013

  
• Molecular Imaging of Cancer ~ Imaging Cellular Proliferation, Hypoxia and Angiogenesis ~

  SAGA Tsuneo

  The 9th Hangzhou International Molecular Imaging Conference, Oct. 2013, Invited

  
• 重粒子線治療とPET

  佐賀 恒夫

  PETサマーセミナー2013 in 加賀百万石, Aug. 2013

  

Books and Other Publications

• Cancer drug delivery systems based on the tumor microenvironment

  Tsuji AB; Saga T, Contributor, CAST diagnostic imaging, pp289-307

  Springer, Tokyo, 2020

  
• Make Life Visible

  Fujibayashi Y; Yoshii Y; Furukawa T; Yoshimoto M; Matsumoto H; Saga T, Contributor, Chapter 29: Imaging and therapy against hypoxic tumors with 64Cu-ATSM. pp285-292

  Springer Nature Singapore Pte Ltd., 2020

  
• Nuclear Oncology

  Jin ZH; Furukawa T; Saga T, Contributor, Chapter 37: Radionuclide imaging of tumor angiogenesis. (pp567-584)

  Wolters Kluwer, 2015, Not refereed

  
• 核医学テキスト

  佐賀 恒夫, Contributor, II. 10-13 FDG以外の製剤 (pp292-297)

  中外医学社, 2013, Not refereed

  
• 肝細胞癌の早期診断：画像と分子マーカー

  佐賀 恒夫, Contributor, II-1-5) 肝細胞癌の分子イメージング (pp207-213)

  アークメディア, 2012, Not refereed

  
• 最先端材料システム One Point

  青木伊知男; 佐賀恒夫, Contributor, 第3章 医療とイメージング (pp55-96)

  共立出版, 2012, Not refereed

  
• Handbook of Targeted Delivery of Imaging Agents

  Jeong JM; Saga T; Lee JT; Koh CS, Contributor, Avidin-biotin system for targeting metastases: Basic aspects. (pp305-319)

  CRC press, 1995, Not refereed

  

Awards

• 15 Oct. 1998

  Japanese Society of Nuclear Medicine, 36th Japanese Society of Nuclear Medicine Award
• Oct. 2017

  Japanese Society of Nuclear Medicine, JSMI Hisada Award 2017 Bronze Prize

External funds: Kakenhi

• Evaluation of pancreatic regeneration and islet number in pancreas and islet transplantation using Positron emission tomography

  Grant-in-Aid for Scientific Research (C)

  National Hospital Organization Chiba-East-Hospital

  KAZUNORI OTSUKI

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  11C-methionine PET;CT　volumetry;膵再生;生体膵ドナー;C-methionine PET;膵臓移植;核医学;PET;11C-methionine;1型糖尿病;膵島移植;生着率;インスリン;ＰＥＴ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09980/
• Basic research program for targeted radionuclide cancer therapy using alpha-particle radiation

  Grant-in-Aid for Scientific Research (B)

  National Institute of Radiological Sciences

  SUMITAKA HASEGAWA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  がん;放射線治療;核医学;内用療法;核医学治療;放射線;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390296/
• Molecular Imaging Research for Forefront of Cardiovascular Medicine

  Grant-in-Aid for Scientific Research (B)

  Kawasaki Medical School;National Institute of Radiological Sciences

  Masayuki INUBUSHI

  From 01 Apr. 2010, To 31 Mar. 2014, Project Closed

  核医学(PETを含む);分子イメージング;循環器;遺伝子治療;再生医療;心臓移植;再生治療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390239/
• Positron emission tomography with 18F-fluorothymidine for monitoring therapeutic effect after chemoradiation therapy

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Yuji NAKAMOTO

  Project Closed

  FLT;FDG;PET;治療効果判定;術前化学療法;腫瘍核医学;画像診断学, FLT;FDG;PET;therapeutic effect;neoadjuvant chemotherapy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591342/
• ESTABLISHMENT AND CLINICAL APPLICATION OF PROLIFERATION ACTIVITY AND MALIGNANT GRADE EVALUATION WITH POSITRON EMISSION TOMOGRAPHY.

  Grant-in-Aid for Scientific Research (C)

  NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES;Kyoto University

  TSUNEO SAGA

  Project Closed

  脳腫瘍;ポジトロン断層法;チミジン誘導体;悪性度診断, brain tumor;positron emission tomography;thymidine derivative;malignant grade evaluation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591265/
• 3T MRI as a tool for noninvasive biomedical imaging of the body

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Kaori TOGASHI

  Project Closed

  MR画像;3テスラ;超高磁場, MR imaging;3T

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16209035/
• EVALUATION OF THERAPEUTIC EFFECT BY POSITRON EMISSION TOMOGRAPHY USING FLUORINATED THYMIDINE DELIVATIVE

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Tsuneo SAGA

  Project Closed

  脳腫瘍;悪性度診断;治療効果判定;ポジトロン断層法;フッ素標識チミジン誘導体, brain tumor;evaluation of malignant potential;evaluation of treatment effect;positron emission tomography;fluorinated thymidine derivative

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15591269/
• ヨード輸送蛋白発現による癌の核医学的治療の基礎的検討

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  御前 隆

  Project Closed

  甲状腺癌;放射性ヨード;内照射治療;ヨード輸送蛋白;甲状腺ペルオキシダーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670931/
• DEVELOPEMENT OF A NOVEL LIVER-SPECIFIC GENE TRANSFER METHOD USING HEPATIC-RECEPTOR IMAGING AGENT

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Tsuneo SAGA

  Project Closed

  アンチセンスオリゴDNA;デンドリマー;肝細胞受容体イメージング;インジウム-111;ネオガラクトシルアルブミン;アビジン, antisense oligo DNA;dendrimer;hepatic receptor imagine;indium-111;neogalactosyl albumin;avidin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670869/
• DEVELOPMENT OF POLYAMINE-GLYCOPROTEIN CONJUGATES FOR INTRACELLULAR DELIVERY OF OLIGO-DNA AND THEIR APPLICATION TO MOLECULAR IMAGING

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Junji KONISHI

  Project Closed

  アンチセンスオリゴDNA;デンドリマー;アビジン;インジウム-111;腹腔内播種;イメージング;内照射療法;遺伝子キャリアー;オージェ電子;内部転換電子, antisense oligo DNA;dendrimer;avidin;indium-111;poritoneal dissemination;imaging;internal radiation therapy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12470188/
• 細胞接着分子を標的とする放射性標識抗体・ペプチドによる癌の診断・治療法の開発

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  佐賀 恒夫

  Project Closed

  細胞接着分子;インテグリン;モノクローナル抗体;放射免疫診断;オートラジオグラフィ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671022/