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Matsubara, Takeshi

Graduate School of Medicine, Medicine Senior Lecturer/ Junior Associate Professor

Matsubara, Takeshi
list
    Last Updated :2022/05/14

    Basic Information

    Faculty

    • 医学部

    Academic Degree

    • 博士(医学)(京都大学)

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 医学部医学科, 卒業

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      Research

      Research Topics, Overview of the research

      • Research Topics

        Basic research in diabetic nephropathy, and clinical research in cancer management in hemodialysis patients
      • Overview of the research

        In basic research, I have been elucidating molecular mechanism of glomerular extracellular matrix expansion in diabetic nephropathy. In clinical research, I have been studying clinical practice patterns of cancer in hemodialysis patients.

      Papers

      • Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy
        Takeshi Matsubara; Makoto Araki; Hideharu Abe; Otoya Ueda; Kou-ichi Jishage; Akira Mima; Chisato Goto; Tatsuya Tominaga; Masahiko Kinosaki; Seiji Kishi; Kojiro Nagai; Noriyuki Iehara; Naoshi Fukushima; Toru Kita; Hidenori Arai; Toshio Doi
        DIABETES, Aug. 2015, Peer-reviewed
      • Onco-nephrology: current concepts and future perspectives
        Yuichiro Kitai; Takeshi Matsubara; Motoko Yanagita
        JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Jul. 2015, Peer-reviewed
      • Physical finding of nutcracker phenomenon.
        Takeshi Matsubara; Osamu Ogawa; Motoko Yanagita
        Kidney international, Feb. 2013, Peer-reviewed
      • Protein Inhibitor of Activated STAT, PIASy Regulates alpha-Smooth Muscle Actin Expression by Interacting with E12 in Mesangial Cells
        Kazuo Torikoshi; Hideharu Abe; Takeshi Matsubara; Takahiro Hirano; Takayuki Ohshima; Taichi Murakami; Makoto Araki; Akira Mima; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Hidenori Arai; Toshio Doi
        PLOS ONE, Jul. 2012, Peer-reviewed
      • Scleraxis Modulates Bone Morphogenetic Protein 4 (BMP4)-Smad1 Protein-Smooth Muscle alpha-Actin (SMA) Signal Transduction in Diabetic Nephropathy
        Hideharu Abe; Tatsuya Tominaga; Takeshi Matsubara; Naoko Abe; Seiji Kishi; Kojiro Nagai; Taichi Murakami; Toshikazu Araoka; Toshio Doi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2012, Peer-reviewed
      • Comparison of the psychosocial quality of life in hemodialysis patients between the elderly and non-elderly using a visual analogue scale: The importance of appetite and depressive mood
        Hiroshi Kanamori; Kojiro Nagai; Takeshi Matsubara; Akira Mima; Motoko Yanagita; Noriyuki Iehara; Hajime Takechi; Keiichi Fujimaki; Kazumasa Usami; Atsushi Fukatsu; Toru Kita; Kozo Matsubayashi; Hidenori Arai
        GERIATRICS & GERONTOLOGY INTERNATIONAL, Jan. 2012, Peer-reviewed
      • Role of Smad1 signaling in pathogenesisof diabetic nephropathy
        T. Tominaga; H. Abe; A. Mima; T. Matsubara; K. Nagai; T. Doi
        Nephropathy: Diagnosis and Treatment, 2012, Peer-reviewed
      • Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice
        Yukinori Tamura; Toshinori Murayama; Manabu Minami; Takeshi Matsubara; Masayuki Yokode; Hidenori Arai
        JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2012, Peer-reviewed
      • SOX9 Protein Induces a Chondrogenic Phenotype of Mesangial Cells and Contributes to Advanced Diabetic Nephropathy
        Seiji Kishi; Hideharu Abe; Haruhiko Akiyama; Tatsuya Tominaga; Taichi Murakami; Akira Mima; Kojiro Nagai; Fumi Kishi; Motokazu Matsuura; Takeshi Matsubara; Noriyuki Iehara; Otoya Ueda; Naoshi Fukushima; Kou-ichi Jishage; Toshio Doi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Peer-reviewed
      • Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy
        Tatsuya Tominaga; Hideharu Abe; Otoya Ueda; Chisato Goto; Kunihiko Nakahara; Taichi Murakami; Takeshi Matsubara; Akira Mima; Kojiro Nagai; Toshikazu Araoka; Seiji Kishi; Naoshi Fukushima; Kou-ichi Jishage; Toshio Doi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed
      • Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker
        Hideharu Abe; Takeshi Matsubara; Hidenori Arai; Toshio Doi
        HISTOLOGY AND HISTOPATHOLOGY, Apr. 2011, Peer-reviewed
      • Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis
        Akira Mima; Hideharu Abe; Kojiro Nagai; Hidenori Arai; Takeshi Matsubara; Makoto Araki; Kazuo Torikoshi; Tatsuya Tominaga; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi
        PLOS ONE, Mar. 2011, Peer-reviewed
      • [IV. Others: 3. Hypokalemia or hypercalcemia-induced renal injuries].
        T. Matsubara; N. Iehara; A. Fukatsu
        Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2011, Peer-reviewed
      • An Autopsy Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS) with Intestinal Bleeding in Chronic Renal Failure
        Akira Mima; Fumihiko Shiota; Takeshi Matsubara; Noriyuki Iehara; Taro Akagi; Hideharu Abe; Kojiro Nagai; Motokazu Matsuura; Taichi Murakami; Seiji Kishi; Toshikazu Araoka; Fumi Kishi; Naoki Kondo; Reiko Shigeta; Kazuhiro Yoshikawa; Toru Kita; Toshio Doi; Atsushi Fukatsu
        RENAL FAILURE, 2011, Peer-reviewed
      • Transcription Factor 7-Like 2 (TCF7L2) Regulates Activin Receptor-Like Kinase 1 (ALK1)/Smad1 Pathway for Development of Diabetic Nephropathy
        Toshikazu Araoka; Hideharu Abe; Tatsuya Tominaga; Akira Mima; Takeshi Matsubara; Taichi Murakami; Seiji Kishi; Kojiro Nagai; Toshio Doi
        MOLECULES AND CELLS, Sep. 2010, Peer-reviewed
      • Acute Renal Failure After Exercise in a Japanese Sumo Wrestler With Renal Hypouricemia
        Akira Mima; Kimiyoshi Ichida; Takeshi Matsubara; Hiroshi Kanamori; Emi Inui; Misa Tanaka; Yumi Manabe; Noriyuki Iehara; Yoshinori Tanaka; Motoko Yanagita; Atsuko Yoshioka; Hidenori Arai; Masashi Kawamura; Katsumasa Usami; Tatsuo Hosoya; Toru Kita; Atsushi Fukatsu
        AMERICAN JOURNAL OF THE MEDICAL SCIENCES, Dec. 2008, Peer-reviewed
      • The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy
        Toshio Doi; Akira Mima; Takeshi Matsubara; Tatsuya Tominaga; Hidenori Arai; Hideharu Abe
        DIABETES RESEARCH AND CLINICAL PRACTICE, Nov. 2008, Peer-reviewed
      • Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy
        Akira Mima; Hidenori Arai; Takeshi Matsubara; Hideharu Abe; Kojiro Nagai; Yukinori Tamura; Kazuo Torikoshi; Makoto Araki; Hiroshi Kanamori; Toshikazu Takahashi; Tatsuya Tominaga; Motokazu Matsuura; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi
        DIABETES, Jun. 2008, Peer-reviewed
      • Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy
        Hiroshi Kanamori; Takeshi Matsubara; Akira Mima; Eriko Sumi; Kojiro Nagai; Toshikazu Takahashi; Hideharu Abe; Noriyuki Iehara; Atsushi Fukatsu; Hiroshi Okamoto; Toru Kita; Toshio Doi; Hidenori Arai
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007, Peer-reviewed
      • SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells
        Eriko Sumi; Noriyuki Iehara; Haruhiko Akiyama; Takeshi Matsubara; Akira Mima; Hiroshi Kanamori; Atsushi Fukatsu; David J. Salant; Toru Kita; Hidenori Arai; Toshio Doi
        AMERICAN JOURNAL OF PATHOLOGY, Jun. 2007, Peer-reviewed
      • Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy
        Akira Mima; Takeshi Matsubara; Hidenori Arai; Hideharu Abe; Kojiro Nagai; Hiroshi Kanamori; Eriko Sumi; Toshikazu Takahashi; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi
        LABORATORY INVESTIGATION, Sep. 2006, Peer-reviewed
      • Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy
        T Matsubara; H Abe; H Arai; K Nagai; A Mima; H Kanamori; E Sumi; T Takahashi; M Matsuura; N Iehara; A Fukatsu; T Kita; T Doi
        LABORATORY INVESTIGATION, Apr. 2006, Peer-reviewed
      • Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy
        K Nagai; T Matsubara; A Mima; E Sumi; H Kanamori; N Iehara; A Fukatsu; M Yanagita; T Nakano; Y Ishimoto; T Kita; T Doi; H Arai
        KIDNEY INTERNATIONAL, Aug. 2005, Peer-reviewed
      • Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis
        T Takahashi; H Abe; H Arai; T Matsubara; K Nagai; M Matsuura; N Iehara; M Yokode; S Nishikawa; T Kita; T Doi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2005, Peer-reviewed
      • Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats
        H Ohashi; H Takagi; S Koyama; H Oh; D Watanabe; D Antonetti; T Matsubara; K Nagai; H Arai; T Kita; Y Honda
        MOLECULAR VISION, Aug. 2004, Peer-reviewed
      • Type IV collagen is transcriptionally regulated by Smad1 under advanced glycation end product (AGE) stimulation
        H Abe; T Matsubara; N Iehara; K Nagai; T Takahashi; H Arai; T Kita; T Doi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2004, Peer-reviewed
      • Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy
        K Nagai; H Arai; M Yanagita; T Matsubara; H Kanamori; T Nakano; N Iehara; A Fukatsu; T Kita; T Doi
        JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, Peer-reviewed

      External funds: Kakenhi

      • Targeting Bone Morphogenetic Protein 4/Smad1 signaling is a new approach for the treatment of glomerulosclerosis
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Matsubara Takeshi
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        糸球体硬化;糖尿病性腎症;BMP 4;Fibronectin;Smad1;糸球体腎炎;病理学
      • Molecular mechanisms of mesangial matrix expansion in the progression of diabetic nephropathy
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Takeshi Matsubara
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        病理学;糖尿病性腎症
      • MOLECULAR MECHANISM OF GLOMERULOSCLEROSIS IN AGING
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Takeshi MATSUBARA
        Project Closed
        老化;細胞・組織;病理学
      • MOLECULAR MECHANISMS OF GLOMERULOSCLEROSIS IN AGING
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Takeshi MATSUBARA
        Project Closed
        腎臓病理;糸球体硬化;老化;細胞・組織;病理学
      • 免疫チェックポイント阻害薬に関連した腎障害における三次リンパ節の機能解析
        Grant-in-Aid for Scientific Research (C)
        Basic Section 53040:Nephrology-related
        Kyoto University
        松原 雄
        From 01 Apr. 2022, To 31 Mar. 2025, Adopted
      list
        Last Updated :2022/05/14

        Education

        Teaching subject(s)

        • From Apr. 2012, To Mar. 2013
          Clinical Physiology
          Spring, 医学部
        • From Apr. 2012, To Mar. 2013
          Clinical Physiology and Diagnosis by Ultrasonography
          Spring, 医学部
        • From Apr. 2013, To Mar. 2014
          Clinical Physiology
          Fall, 医学部(人間健康科学科)
        • From Apr. 2013, To Mar. 2014
          Clinical Physiology
          Spring, 医学部(人間健康科学科)
        • From Apr. 2013, To Mar. 2014
          Clinical Physiology and Diagnosis by Ultrasonography
          Fall, 医学部(人間健康科学科)
        • From Apr. 2014, To Mar. 2015
          Clinical Physiology
          Fall, 医学部(人間健康科学科)
        • From Apr. 2014, To Mar. 2015
          Clinical Physiology
          Spring, 医学部(人間健康科学科)
        • From Apr. 2014, To Mar. 2015
          Clinical Physiology and Diagnosis by Ultrasonography
          Fall, 医学部(人間健康科学科)
        • From Apr. 2015, To Mar. 2016
          Clinical Physiology and Diagnosis by Ultrasonography
          Fall, 医学部(人間健康科学科)
        • From Apr. 2016, To Mar. 2017
          Clinical Physiology and Diagnosis by Ultrasonography
          Fall, 医学部(人間健康科学科)
        • From Apr. 2017, To Mar. 2018
          Clinical Physiology and Diagnosis by Ultrasonography
          Fall, 医学部(人間健康科学科)
        • From Apr. 2019, To Mar. 2020
          Clinical Physiology and Diagnosis by Ultrasonography II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2020, To Mar. 2021
          Clinical Physiology and Diagnosis by Ultrasonography II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2021, To Mar. 2022
          Clinical Physiology and Diagnosis by Ultrasonography II
          Fall, 医学部(人間健康科学科)

        Part-time lecturer

        • From 01 Oct. 2019, To 31 Mar. 2020
          酸塩基平衡の調節機構
          公立大学法人大阪市立大学
        • From 01 Oct. 2019, To 31 Mar. 2020
          水・電解質の調節機構
          公立大学法人大阪市立大学
        list
          Last Updated :2022/05/14

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2008
            外来医長・看護師長会議 委員

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