Basic Information

Faculty

• 医学部

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

ID,URL

• J-Global ID

  201401086250460848

researchmap URL

• https://researchmap.jp/7000008712

Research

Research Topics, Overview of the research

• Research Topics

  Basic research in diabetic nephropathy, and clinical research in cancer management in hemodialysis patients

• Overview of the research

  In basic research, I have been elucidating molecular mechanism of glomerular extracellular matrix expansion in diabetic nephropathy. In clinical research, I have been studying clinical practice patterns of cancer in hemodialysis patients.

Papers

• Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy

  Takeshi Matsubara; Makoto Araki; Hideharu Abe; Otoya Ueda; Kou-ichi Jishage; Akira Mima; Chisato Goto; Tatsuya Tominaga; Masahiko Kinosaki; Seiji Kishi; Kojiro Nagai; Noriyuki Iehara; Naoshi Fukushima; Toru Kita; Hidenori Arai; Toshio Doi

  DIABETES, Aug. 2015, Peer-reviewed

  
• Onco-nephrology: current concepts and future perspectives

  Yuichiro Kitai; Takeshi Matsubara; Motoko Yanagita

  JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Jul. 2015, Peer-reviewed

  
• Physical finding of nutcracker phenomenon.

  Takeshi Matsubara; Osamu Ogawa; Motoko Yanagita

  Kidney international, Feb. 2013, Peer-reviewed

  
• Protein Inhibitor of Activated STAT, PIASy Regulates alpha-Smooth Muscle Actin Expression by Interacting with E12 in Mesangial Cells

  Kazuo Torikoshi; Hideharu Abe; Takeshi Matsubara; Takahiro Hirano; Takayuki Ohshima; Taichi Murakami; Makoto Araki; Akira Mima; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Hidenori Arai; Toshio Doi

  PLOS ONE, Jul. 2012, Peer-reviewed

  
• Scleraxis Modulates Bone Morphogenetic Protein 4 (BMP4)-Smad1 Protein-Smooth Muscle alpha-Actin (SMA) Signal Transduction in Diabetic Nephropathy

  Hideharu Abe; Tatsuya Tominaga; Takeshi Matsubara; Naoko Abe; Seiji Kishi; Kojiro Nagai; Taichi Murakami; Toshikazu Araoka; Toshio Doi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2012, Peer-reviewed

  
• Comparison of the psychosocial quality of life in hemodialysis patients between the elderly and non-elderly using a visual analogue scale: The importance of appetite and depressive mood

  Hiroshi Kanamori; Kojiro Nagai; Takeshi Matsubara; Akira Mima; Motoko Yanagita; Noriyuki Iehara; Hajime Takechi; Keiichi Fujimaki; Kazumasa Usami; Atsushi Fukatsu; Toru Kita; Kozo Matsubayashi; Hidenori Arai

  GERIATRICS & GERONTOLOGY INTERNATIONAL, Jan. 2012, Peer-reviewed

  
• Role of Smad1 signaling in pathogenesisof diabetic nephropathy

  T. Tominaga; H. Abe; A. Mima; T. Matsubara; K. Nagai; T. Doi

  Nephropathy: Diagnosis and Treatment, 2012, Peer-reviewed

  
• Ezetimibe Ameliorates Early Diabetic Nephropathy in db/db Mice

  Yukinori Tamura; Toshinori Murayama; Manabu Minami; Takeshi Matsubara; Masayuki Yokode; Hidenori Arai

  JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2012, Peer-reviewed

  
• SOX9 Protein Induces a Chondrogenic Phenotype of Mesangial Cells and Contributes to Advanced Diabetic Nephropathy

  Seiji Kishi; Hideharu Abe; Haruhiko Akiyama; Tatsuya Tominaga; Taichi Murakami; Akira Mima; Kojiro Nagai; Fumi Kishi; Motokazu Matsuura; Takeshi Matsubara; Noriyuki Iehara; Otoya Ueda; Naoshi Fukushima; Kou-ichi Jishage; Toshio Doi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Peer-reviewed

  
• Activation of Bone Morphogenetic Protein 4 Signaling Leads to Glomerulosclerosis That Mimics Diabetic Nephropathy

  Tatsuya Tominaga; Hideharu Abe; Otoya Ueda; Chisato Goto; Kunihiko Nakahara; Taichi Murakami; Takeshi Matsubara; Akira Mima; Kojiro Nagai; Toshikazu Araoka; Seiji Kishi; Naoshi Fukushima; Kou-ichi Jishage; Toshio Doi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker

  Hideharu Abe; Takeshi Matsubara; Hidenori Arai; Toshio Doi

  HISTOLOGY AND HISTOPATHOLOGY, Apr. 2011, Peer-reviewed

  
• Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

  Akira Mima; Hideharu Abe; Kojiro Nagai; Hidenori Arai; Takeshi Matsubara; Makoto Araki; Kazuo Torikoshi; Tatsuya Tominaga; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi

  PLOS ONE, Mar. 2011, Peer-reviewed

  
• [IV. Others: 3. Hypokalemia or hypercalcemia-induced renal injuries].

  T. Matsubara; N. Iehara; A. Fukatsu

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2011, Peer-reviewed

  
• An Autopsy Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS) with Intestinal Bleeding in Chronic Renal Failure

  Akira Mima; Fumihiko Shiota; Takeshi Matsubara; Noriyuki Iehara; Taro Akagi; Hideharu Abe; Kojiro Nagai; Motokazu Matsuura; Taichi Murakami; Seiji Kishi; Toshikazu Araoka; Fumi Kishi; Naoki Kondo; Reiko Shigeta; Kazuhiro Yoshikawa; Toru Kita; Toshio Doi; Atsushi Fukatsu

  RENAL FAILURE, 2011, Peer-reviewed

  
• Transcription Factor 7-Like 2 (TCF7L2) Regulates Activin Receptor-Like Kinase 1 (ALK1)/Smad1 Pathway for Development of Diabetic Nephropathy

  Toshikazu Araoka; Hideharu Abe; Tatsuya Tominaga; Akira Mima; Takeshi Matsubara; Taichi Murakami; Seiji Kishi; Kojiro Nagai; Toshio Doi

  MOLECULES AND CELLS, Sep. 2010, Peer-reviewed

  
• Acute Renal Failure After Exercise in a Japanese Sumo Wrestler With Renal Hypouricemia

  Akira Mima; Kimiyoshi Ichida; Takeshi Matsubara; Hiroshi Kanamori; Emi Inui; Misa Tanaka; Yumi Manabe; Noriyuki Iehara; Yoshinori Tanaka; Motoko Yanagita; Atsuko Yoshioka; Hidenori Arai; Masashi Kawamura; Katsumasa Usami; Tatsuo Hosoya; Toru Kita; Atsushi Fukatsu

  AMERICAN JOURNAL OF THE MEDICAL SCIENCES, Dec. 2008, Peer-reviewed

  
• The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy

  Toshio Doi; Akira Mima; Takeshi Matsubara; Tatsuya Tominaga; Hidenori Arai; Hideharu Abe

  DIABETES RESEARCH AND CLINICAL PRACTICE, Nov. 2008, Peer-reviewed

  
• Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy

  Akira Mima; Hidenori Arai; Takeshi Matsubara; Hideharu Abe; Kojiro Nagai; Yukinori Tamura; Kazuo Torikoshi; Makoto Araki; Hiroshi Kanamori; Toshikazu Takahashi; Tatsuya Tominaga; Motokazu Matsuura; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi

  DIABETES, Jun. 2008, Peer-reviewed

  
• Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy

  Hiroshi Kanamori; Takeshi Matsubara; Akira Mima; Eriko Sumi; Kojiro Nagai; Toshikazu Takahashi; Hideharu Abe; Noriyuki Iehara; Atsushi Fukatsu; Hiroshi Okamoto; Toru Kita; Toshio Doi; Hidenori Arai

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007, Peer-reviewed

  
• SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells

  Eriko Sumi; Noriyuki Iehara; Haruhiko Akiyama; Takeshi Matsubara; Akira Mima; Hiroshi Kanamori; Atsushi Fukatsu; David J. Salant; Toru Kita; Hidenori Arai; Toshio Doi

  AMERICAN JOURNAL OF PATHOLOGY, Jun. 2007, Peer-reviewed

  
• Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy

  Akira Mima; Takeshi Matsubara; Hidenori Arai; Hideharu Abe; Kojiro Nagai; Hiroshi Kanamori; Eriko Sumi; Toshikazu Takahashi; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi

  LABORATORY INVESTIGATION, Sep. 2006, Peer-reviewed

  
• Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy

  T Matsubara; H Abe; H Arai; K Nagai; A Mima; H Kanamori; E Sumi; T Takahashi; M Matsuura; N Iehara; A Fukatsu; T Kita; T Doi

  LABORATORY INVESTIGATION, Apr. 2006, Peer-reviewed

  
• Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy

  K Nagai; T Matsubara; A Mima; E Sumi; H Kanamori; N Iehara; A Fukatsu; M Yanagita; T Nakano; Y Ishimoto; T Kita; T Doi; H Arai

  KIDNEY INTERNATIONAL, Aug. 2005, Peer-reviewed

  
• Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis

  T Takahashi; H Abe; H Arai; T Matsubara; K Nagai; M Matsuura; N Iehara; M Yokode; S Nishikawa; T Kita; T Doi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2005, Peer-reviewed

  
• Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats

  H Ohashi; H Takagi; S Koyama; H Oh; D Watanabe; D Antonetti; T Matsubara; K Nagai; H Arai; T Kita; Y Honda

  MOLECULAR VISION, Aug. 2004, Peer-reviewed

  
• Type IV collagen is transcriptionally regulated by Smad1 under advanced glycation end product (AGE) stimulation

  H Abe; T Matsubara; N Iehara; K Nagai; T Takahashi; H Arai; T Kita; T Doi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2004, Peer-reviewed

  
• Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy

  K Nagai; H Arai; M Yanagita; T Matsubara; H Kanamori; T Nakano; N Iehara; A Fukatsu; T Kita; T Doi

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, Peer-reviewed

  

External funds: Kakenhi

• Targeting Bone Morphogenetic Protein 4/Smad1 signaling is a new approach for the treatment of glomerulosclerosis

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Matsubara Takeshi

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  糸球体硬化;糖尿病性腎症;BMP 4;Fibronectin;Smad1;糸球体腎炎;病理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09613/
• Molecular mechanisms of mesangial matrix expansion in the progression of diabetic nephropathy

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Takeshi Matsubara

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  病理学;糖尿病性腎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461221/
• MOLECULAR MECHANISM OF GLOMERULOSCLEROSIS IN AGING

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Takeshi MATSUBARA

  Project Closed

  老化;細胞・組織;病理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790808/
• MOLECULAR MECHANISMS OF GLOMERULOSCLEROSIS IN AGING

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Takeshi MATSUBARA

  Project Closed

  腎臓病理;糸球体硬化;老化;細胞・組織;病理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790580/
• 免疫チェックポイント阻害薬に関連した腎障害における三次リンパ節の機能解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53040:Nephrology-related

  Kyoto University

  松原 雄

  From 01 Apr. 2022, To 31 Mar. 2025, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08350/

Education

Teaching subject(s)

• From Apr. 2012, To Mar. 2013

  Clinical Physiology

  Spring, 医学部
• From Apr. 2012, To Mar. 2013

  Clinical Physiology and Diagnosis by Ultrasonography

  Spring, 医学部
• From Apr. 2013, To Mar. 2014

  Clinical Physiology

  Fall, 医学部（人間健康科学科）
• From Apr. 2013, To Mar. 2014

  Clinical Physiology

  Spring, 医学部（人間健康科学科）
• From Apr. 2013, To Mar. 2014

  Clinical Physiology and Diagnosis by Ultrasonography

  Fall, 医学部（人間健康科学科）
• From Apr. 2014, To Mar. 2015

  Clinical Physiology

  Fall, 医学部（人間健康科学科）
• From Apr. 2014, To Mar. 2015

  Clinical Physiology

  Spring, 医学部（人間健康科学科）
• From Apr. 2014, To Mar. 2015

  Clinical Physiology and Diagnosis by Ultrasonography

  Fall, 医学部（人間健康科学科）
• From Apr. 2015, To Mar. 2016

  Clinical Physiology and Diagnosis by Ultrasonography

  Fall, 医学部（人間健康科学科）
• From Apr. 2016, To Mar. 2017

  Clinical Physiology and Diagnosis by Ultrasonography

  Fall, 医学部（人間健康科学科）
• From Apr. 2017, To Mar. 2018

  Clinical Physiology and Diagnosis by Ultrasonography

  Fall, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Clinical Physiology and Diagnosis by Ultrasonography II

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Clinical Physiology and Diagnosis by Ultrasonography II

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Clinical Physiology and Diagnosis by Ultrasonography II

  Fall, 医学部（人間健康科学科）

Part-time lecturer

• From 01 Oct. 2019, To 31 Mar. 2020

  酸塩基平衡の調節機構

  公立大学法人大阪市立大学
• From 01 Oct. 2019, To 31 Mar. 2020

  水・電解質の調節機構

  公立大学法人大阪市立大学

Administration

Faculty management (title, position)

• From 01 Apr. 2008

  外来医長・看護師長会議 委員