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Harumoto, Toshiyuki

The HAKUBI Center for Advanced Research Program-Specific Assistant Professor

Harumoto, Toshiyuki
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    Last Updated :2024/04/22

    Basic Information

    Professional Memberships

    • From Apr. 2021, To Present
      The Zoological Society of Japan

    Academic Degree

    • M.Sc.(Kobe University)
    • Ph.D.(Kyoto University)

    Academic Resume (Graduate Schools)

    • Kobe University, Graduate School of Human Development, 修了
    • Kyoto University, Graduate School of Biostudies, 修了

    Academic Resume (Undergraduate School/Majors)

    • Kobe University, Faculty of Human Development, 卒業

    Research History

    • From Oct. 2019, To Present
      The Hakubi Center for Advanced Research, Kyoto University, Assistant Professor
    • From Apr. 2015, To Sep. 2019
      École polytechnique fédérale de Lausanne (EPFL), Post-doctoral fellow
    • From Apr. 2012, To Mar. 2015
      National Institute of Advanced Industrial Science and Technology, JSPS Research Fellow PD

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2024/04/22

      Research

      Research Interests

      • Wolbachia
      • reproductive manipulation
      • cellular biology
      • molecular genetics
      • Developmental biology
      • Spiroplasma
      • symbiotic bacteria
      • symbiotic microorganisms
      • Drosophila
      • insects
      • endosymbiosis

      Research Areas

      • Life sciences, Genetics
      • Life sciences, Bacteriology
      • Environmental science/Agricultural science, Entomology
      • Life sciences, Cell biology
      • Life sciences, Molecular biology
      • Life sciences, Developmental biology

      Papers

      • Self-stabilization mechanism encoded by a bacterial toxin facilitates reproductive parasitism
        Toshiyuki Harumoto
        Current Biology, 25 Sep. 2023, Peer-reviewed, Lead author, Last author, Corresponding author
      • Combined actions of bacteriophage-encoded genes in Wolbachia-induced male lethality
        Hiroshi Arai; Hisashi Anbutsu; Yohei Nishikawa; Masato Kogawa; Kazuo Ishii; Masahito Hosokawa; Shiou-Ruei Lin; Masatoshi Ueda; Madoka Nakai; Yasuhisa Kunimi; Toshiyuki Harumoto; Daisuke Kageyama; Haruko Takeyama; Maki N. Inoue
        iScience, 16 Jun. 2023, Peer-reviewed
      • Mechanisms underpinning morphogenesis of a symbiotic organ specialized for hosting an indispensable microbial symbiont in stinkbugs
        Sayumi Oishi; Toshiyuki Harumoto; Keiko Okamoto-Furuta; Minoru Moriyama; Takema Fukatsu
        mBio, 25 Apr. 2023, Peer-reviewed
      • A male-killing gene encoded by a symbiotic virus of Drosophila.
        Daisuke Kageyama; Toshiyuki Harumoto; Keisuke Nagamine; Akiko Fujiwara; Takafumi N Sugimoto; Akiya Jouraku; Masaru Tamura; Takehiro K Katoh; Masayoshi Watada
        Nature Communications, 13 Mar. 2023, Peer-reviewed, Lead author
      • Perplexing dynamics of Wolbachia proteins for cytoplasmic incompatibility.
        Toshiyuki Harumoto; Takema Fukatsu
        PLoS Biology, 25 May 2022, Peer-reviewed, Invited, Lead author, Corresponding author
      • Male-killing toxin in a bacterial symbiont of Drosophila
        Toshiyuki Harumoto; Bruno Lemaitre
        Nature, May 2018, Peer-reviewed, Lead author, Corresponding author
      • Common and unique strategies of male killing evolved in two distinct Drosophila symbionts
        Toshiyuki Harumoto; Takema Fukatsu; Bruno Lemaitre
        Proceedings of the Royal Society B: Biological Sciences, 28 Mar. 2018, Peer-reviewed, Lead author, Corresponding author
      • Male-killing symbiont damages host's dosage-compensated sex chromosome to induce embryonic apoptosis
        Toshiyuki Harumoto; Hisashi Anbutsu; Bruno Lemaitre; Takema Fukatsu
        Nature Communications, Sep. 2016, Peer-reviewed, Lead author, Corresponding author
      • Male-killing Spiroplasma induces sex-specific cell death via host apoptotic pathway
        Toshiyuki Harumoto; Hisashi Anbutsu; Takema Fukatsu
        PLoS Pathogens, Feb. 2014, Peer-reviewed, Lead author
      • Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity
        Toshiyuki Harumoto; Masayoshi Ito; Yuko Shimada; Tetsuya J. Kobayashi; Hiroki R. Ueda; Bingwei Lu; Tadashi Uemura
        Developmental Cell, Sep. 2010, Peer-reviewed, Lead author
      • Wing-to-leg homeosis by spineless causes apoptosis regulated by fish-lips, a novel leucine-rich repeat transmembrane protein
        T Adachi-Yamada; T Harumoto; K Sakurai; R Ueda; K Saigo; MB O'Connor; H Nakato
        Molecular and Cellular Biology, Apr. 2005, Peer-reviewed

      Misc.

      • Overgrowth-induced apoptosis by dco3, a Drosophila mutant allele for Casein kinase Iδ/ε
        Adachi-Yamada Takashi; Harumoto Toshiyuki; Okabe Atsushi; Takemura Masahiko; Maeda Kousuke; Umemori Makoto; Tagami Ayumu; Shimoda Masami
        New Development in Cell Apoptosis Research, 2007, Peer-reviewed
      • 2006 Patterns of the stress field and dynamics of morphogenesis
        Sugimura Kaoru; Ishihara Shuji; Harumoto Toshiyuki; Uemura Tadashi; Kaneko Kunihiko; Miyawaki Atsushi
        The Computational Mechanics Conference, 23 Sep. 2010
      • 共生細菌スピロプラズマによる雄殺し : その表現型と分子機構 (特集 明らかになりつつある共生細菌による昆虫の生殖操作メカニズム)
        春本 敏之
        蚕糸・昆虫バイオテック, Dec. 2018, Invited
      • 昆虫の共生細菌がもつ雄殺し毒素の発見
        春本 敏之
        実験医学「カレントトピックス」, Oct. 2018, Invited
      • 共生細菌の産生するオス殺し毒素
        春本 敏之
        ライフサイエンス 新着論文レビュー, May 2018, Invited
      • 微小管がつかさどる細胞ダイナミクス 平面上において全組織非対称性をどのようにして細胞極性へと関連させるのか(How to connect global tissue asymmetry to cell polarity on the plane)
        上村 匡; 春本 敏之; 島田 裕子; 上田 泰己; 小林 徹也
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008
      • Host-symbiont interactions in Drosophila-Spiroplasma endosymbiosis
        安佛 尚志; 春本 敏之; 二河 成男
        日本マイコプラズマ学会雑誌 = Japanese journal of mycoplasmology, 23 May 2014

      Presentations

      • Reproductive manipulators in insects
        Toshiyuki Harumoto
        Hakubi Camp, 04 Dec. 2023, 京都大学白眉センター
      • Self-stabilization mechanism encoded by a bacterial toxin facilitates reproductive manipulation
        Toshiyuki Harumoto
        The 11th International Wolbachia Conference, 14 Jun. 2023
      • ショウジョウバエ共生微生物によるオス殺し:オス殺し因子の作用機序を追究する
        春本 敏之
        ERATO公開シンポジウム「延長された表現型の機構解明 〜生物がいかにして他の生物を改変、操作するのか〜」, 19 Feb. 2023, ERATO深津共生進化機構, Invited
      • 昆⾍の性を操る共⽣微⽣物たち 〜なぜ・いかに操作するのか︖〜
        春本 敏之
        世界の《不思議》に迫る︕京⼤「⽩眉」研究者たち【京都⼤学⽩眉センター× NHKカルチャー】, 24 Dec. 2022, NHKカルチャー京都, Invited
      • The action mechanisms of male-killing toxin produced by insect symbionts
        春本 敏之
        日本動物学会 第93回 早稲田大会, 10 Sep. 2022, 日本動物学会
      • スピロプラズマのオス殺し毒素−発見とその後の研究展開−
        春本 敏之
        第49回日本マイコプラズマ学会学術集会, 28 May 2022, 日本マイコプラズマ学会, Invited
      • The action mechanisms of male-killing toxin produced by Drosophila symbionts
        Toshiyuki Harumoto
        Max Planck Institute for Infection Biology webinar "New Voices in Infection Biology", 11 May 2022, Max Planck Institute for Infection Biology, Invited
      • The action mechanisms of male-killing toxin produced by Drosophila symbionts
        Toshiyuki Harumoto
        The 14th Japan Drosophila Research Conference, 15 Sep. 2021, Japan Drosophila Research Conference
      • 昆虫の性を操る共生微生物たち
        春本 敏之
        日本蚕糸学会第 91 回大会, 20 Mar. 2021, 日本蚕糸学会, Invited
      • 昆虫の生殖を操る共生微生物たち
        春本 敏之
        第22回日本進化学会オンライン大会「進化学夏の学校 機能ゲノミクスからせまる進化学研究」, 06 Sep. 2020, 日本進化学会, Invited
      • Reproductive manipulation caused by bacterial symbionts
        Toshiyuki Harumoto
        Chromatin seminar in Biomedical Center of LMU, 06 Sep. 2018, LMU Munich, Invited
      • Male-killing toxin produced by a bacterial symbiont
        Toshiyuki Harumoto
        The 10th International Wolbachia Conference, 19 Jun. 2018
      • Male-killing toxin produced by a bacterial symbiont
        Toshiyuki Harumoto
        Royal Entomological Society endosymbiont SIG meeting, 21 Mar. 2018, Royal Entomological Society
      • 共生細菌による昆虫性比操作の分子機構
        春本 敏之
        第8回細菌学若手コロッセウム, 07 Aug. 2014, 細菌学若手コロッセウム, Invited
      • Spiroplasma infection induces male-specific DNA damage response in Drosophila melanogaster
        Toshiyuki Harumoto
        The 8th International Wolbachia Conference, 10 Jun. 2014
      • 器官のグローバルな非対称性と一細胞の極性を結びつける機構の解明
        春本 敏之; 島田 裕子; 上村 匡
        第82回日本生化学会大会, 24 Oct. 2009, 日本生化学会, Invited
      • Atypical cadherins Dachsous and Fat control alignment and polarity of microtubules in planar cell polarity
        Toshiyuki Harumoto
        The 9th Japan Drosophila Research Conference, 07 Jul. 2009, Japan Drosophila Research Conference

      Awards

      • 01 Apr. 2022
        Nagase Science and Technology Foundation, Nagase Foundation Award
        Japan, Publisher
        Toshiyuki Harumoto
      • 04 Feb. 2013
        Inoue Foundation for Science, The 29th Inoue Research Award for Young Scientists
        Japan, Publisher
        Toshiyuki Harumoto

      Media Coverage

      • 「オス殺し」毒素の作用メカニズムを解明
        国立研究開発法人 科学技術振興機構, JSTnews, NEWS & TOPICS, 01 Dec. 2023, Pr
      • オス殺し毒素で「性」操る細菌
        東京新聞 TOKYO Web, 社会・科学欄 <フロンティア発>, 01 Oct. 2023, Paper
      • オス殺しのコストパフォーマンスが高いわけ ―共生細菌の毒素は自己安定化のしくみをもつ―
        京都大学大学院生命科学研究科, 27 Sep. 2023, Pr
      • オス殺しのコストパフォーマンスが高いわけ―共生細菌の毒素は自己安定化のしくみをもつ―
        京都大学, 08 Sep. 2023, Pr
      • Mystery solved: The bacterial protein that kills male fruit flies
        École Polytechnique Fédérale de Lausanne, 07 May 2018, Pr
      • 「メスのみ孵化」解明-産総研 天敵農薬への応用期待
        化学工業日報, 5面(ライフイノベーション), 26 Sep. 2016, Paper
      • 共生細菌が宿主昆虫をメスだけにするしくみを解明 -オスのX染色体を切断して細胞死を引き起こす-
        国立研究開発法人 産業技術総合研究所, 23 Sep. 2016, Pr

      External funds: Kakenhi

      • 液性免疫を司る経路の使い方は個体ごとにゆらぐ?
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
        National Agriculture and Food Research Organization
        西出 雄大
        From 30 Jun. 2022, To 31 Mar. 2024, Granted
        昆虫免疫;液性免疫;IMD経路;Toll経路;抗菌性タンパク質;抗菌ペプチド

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