Harumoto, Toshiyuki(The HAKUBI Center for Advanced Research) | Activity Database on Education and Research, Kyoto University

Harumoto, Toshiyuki

The HAKUBI Center for Advanced Research Program-Specific Assistant Professor

Last Updated :2023/09/30

Basic Information

Professional Memberships

From Apr. 2021, To Present
The Zoological Society of Japan

Academic Degree

M.Sc.(Kobe University)

Ph.D.(Kyoto University)

Academic Resume (Graduate Schools)

Kobe University, Graduate School of Human Development, 修了

Kyoto University, Graduate School of Biostudies, 修了

Academic Resume (Undergraduate School/Majors)

Kobe University, Faculty of Human Development, 卒業

Research History

From Oct. 2019, To Present
The Hakubi Center for Advanced Research, Kyoto University, Assistant Professor

From Apr. 2015, To Sep. 2019
École polytechnique fédérale de Lausanne (EPFL), Post-doctoral fellow

From Apr. 2012, To Mar. 2015
National Institute of Advanced Industrial Science and Technology, JSPS Research Fellow PD

ID,URL

ORCID ID
0000-0003-4394-5883
J-Global ID
201901014509898274
Researcher number
60727387

Website(s) (URL(s))

https://www.hakubi.kyoto-u.ac.jp/mem/mem-10/member-10-10

researchmap URL

https://researchmap.jp/toshiyukiharumoto

Last Updated :2023/09/30

Research

Research Interests

Wolbachia

reproductive manipulation

cellular biology

molecular genetics

Developmental biology

Spiroplasma

symbiotic bacteria

symbiotic microorganisms

Drosophila

insects

endosymbiosis

Research Areas

Life sciences, Genetics

Life sciences, Bacteriology

Environmental science/Agricultural science, Entomology

Life sciences, Cell biology

Life sciences, Molecular biology

Life sciences, Developmental biology

Papers

Self-stabilization mechanism encoded by a bacterial toxin facilitates reproductive parasitism
Toshiyuki Harumoto
Current Biology, 25 Sep. 2023, Peer-reviewed, Lead author, Last author, Corresponding author

Combined actions of bacteriophage-encoded genes in Wolbachia-induced male lethality
Hiroshi Arai; Hisashi Anbutsu; Yohei Nishikawa; Masato Kogawa; Kazuo Ishii; Masahito Hosokawa; Shiou-Ruei Lin; Masatoshi Ueda; Madoka Nakai; Yasuhisa Kunimi; Toshiyuki Harumoto; Daisuke Kageyama; Haruko Takeyama; Maki N. Inoue
iScience, Jun. 2023, Peer-reviewed

Mechanisms underpinning morphogenesis of a symbiotic organ specialized for hosting an indispensable microbial symbiont in stinkbugs
Sayumi Oishi; Toshiyuki Harumoto; Keiko Okamoto-Furuta; Minoru Moriyama; Takema Fukatsu
mBio, 25 Apr. 2023, Peer-reviewed

A male-killing gene encoded by a symbiotic virus of Drosophila.
Daisuke Kageyama; Toshiyuki Harumoto; Keisuke Nagamine; Akiko Fujiwara; Takafumi N Sugimoto; Akiya Jouraku; Masaru Tamura; Takehiro K Katoh; Masayoshi Watada
Nature Communications, 13 Mar. 2023, Peer-reviewed, Lead author

Perplexing dynamics of Wolbachia proteins for cytoplasmic incompatibility.
Toshiyuki Harumoto; Takema Fukatsu
PLoS Biology, 25 May 2022, Peer-reviewed, Invited, Lead author, Corresponding author

Male-killing toxin in a bacterial symbiont of Drosophila
Toshiyuki Harumoto; Bruno Lemaitre
Nature, May 2018, Peer-reviewed, Lead author, Corresponding author

Common and unique strategies of male killing evolved in two distinct Drosophila symbionts
Toshiyuki Harumoto; Takema Fukatsu; Bruno Lemaitre
Proceedings of the Royal Society B: Biological Sciences, 28 Mar. 2018, Peer-reviewed, Lead author, Corresponding author

Male-killing symbiont damages host's dosage-compensated sex chromosome to induce embryonic apoptosis
Toshiyuki Harumoto; Hisashi Anbutsu; Bruno Lemaitre; Takema Fukatsu
Nature Communications, Sep. 2016, Peer-reviewed, Lead author, Corresponding author

Male-killing Spiroplasma induces sex-specific cell death via host apoptotic pathway
Toshiyuki Harumoto; Hisashi Anbutsu; Takema Fukatsu
PLoS Pathogens, Feb. 2014, Peer-reviewed, Lead author

Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity
Toshiyuki Harumoto; Masayoshi Ito; Yuko Shimada; Tetsuya J. Kobayashi; Hiroki R. Ueda; Bingwei Lu; Tadashi Uemura
Developmental Cell, Sep. 2010, Peer-reviewed, Lead author

Wing-to-leg homeosis by spineless causes apoptosis regulated by fish-lips, a novel leucine-rich repeat transmembrane protein
T Adachi-Yamada; T Harumoto; K Sakurai; R Ueda; K Saigo; MB O'Connor; H Nakato
Molecular and Cellular Biology, Apr. 2005, Peer-reviewed

Misc.

Overgrowth-induced apoptosis by dco3, a Drosophila mutant allele for Casein kinase Iδ/ε
Adachi-Yamada Takashi; Harumoto Toshiyuki; Okabe Atsushi; Takemura Masahiko; Maeda Kousuke; Umemori Makoto; Tagami Ayumu; Shimoda Masami
New Development in Cell Apoptosis Research, 2007, Peer-reviewed

2006 Patterns of the stress field and dynamics of morphogenesis
Sugimura Kaoru; Ishihara Shuji; Harumoto Toshiyuki; Uemura Tadashi; Kaneko Kunihiko; Miyawaki Atsushi
The Computational Mechanics Conference, 23 Sep. 2010

共生細菌スピロプラズマによる雄殺し : その表現型と分子機構 (特集明らかになりつつある共生細菌による昆虫の生殖操作メカニズム)
春本敏之
蚕糸・昆虫バイオテック, Dec. 2018, Invited

昆虫の共生細菌がもつ雄殺し毒素の発見
春本敏之
実験医学「カレントトピックス」, Oct. 2018, Invited

共生細菌の産生するオス殺し毒素
春本敏之
ライフサイエンス新着論文レビュー, May 2018, Invited

微小管がつかさどる細胞ダイナミクス平面上において全組織非対称性をどのようにして細胞極性へと関連させるのか(How to connect global tissue asymmetry to cell polarity on the plane)
上村匡; 春本敏之; 島田裕子; 上田泰己; 小林徹也
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

Host-symbiont interactions in Drosophila-Spiroplasma endosymbiosis
安佛尚志; 春本敏之; 二河成男
日本マイコプラズマ学会雑誌 = Japanese journal of mycoplasmology, 23 May 2014

Presentations

Self-stabilization mechanism encoded by a bacterial toxin facilitates reproductive manipulation
Toshiyuki Harumoto
The 11th International Wolbachia Conference, 14 Jun. 2023

ショウジョウバエ共生微生物によるオス殺し：オス殺し因子の作用機序を追究する
春本敏之
ERATO公開シンポジウム「延長された表現型の機構解明〜生物がいかにして他の生物を改変、操作するのか〜」, 19 Feb. 2023, ERATO深津共生進化機構, Invited

昆⾍の性を操る共⽣微⽣物たち〜なぜ・いかに操作するのか︖〜
春本敏之
世界の《不思議》に迫る︕京⼤「⽩眉」研究者たち【京都⼤学⽩眉センター× NHKカルチャー】, 24 Dec. 2022, NHKカルチャー京都, Invited

The action mechanisms of male-killing toxin produced by insect symbionts
春本敏之
日本動物学会第93回早稲田大会, 10 Sep. 2022, 日本動物学会

スピロプラズマのオス殺し毒素−発見とその後の研究展開−
春本敏之
第49回日本マイコプラズマ学会学術集会, 28 May 2022, 日本マイコプラズマ学会, Invited

The action mechanisms of male-killing toxin produced by Drosophila symbionts
Toshiyuki Harumoto
Max Planck Institute for Infection Biology webinar "New Voices in Infection Biology", 11 May 2022, Max Planck Institute for Infection Biology, Invited

The action mechanisms of male-killing toxin produced by Drosophila symbionts
Toshiyuki Harumoto
The 14th Japan Drosophila Research Conference, 15 Sep. 2021, Japan Drosophila Research Conference

昆虫の性を操る共生微生物たち
春本敏之
日本蚕糸学会第 91 回大会, 20 Mar. 2021, 日本蚕糸学会, Invited

昆虫の生殖を操る共生微生物たち
春本敏之
第22回日本進化学会オンライン大会「進化学夏の学校機能ゲノミクスからせまる進化学研究」, 06 Sep. 2020, 日本進化学会, Invited

Reproductive manipulation caused by bacterial symbionts
Toshiyuki Harumoto
Chromatin seminar in Biomedical Center of LMU, 06 Sep. 2018, LMU Munich, Invited

Male-killing toxin produced by a bacterial symbiont
Toshiyuki Harumoto
The 10th International Wolbachia Conference, 19 Jun. 2018

Male-killing toxin produced by a bacterial symbiont
Toshiyuki Harumoto
Royal Entomological Society endosymbiont SIG meeting, 21 Mar. 2018, Royal Entomological Society

共生細菌による昆虫性比操作の分子機構
春本敏之
第８回細菌学若手コロッセウム, 07 Aug. 2014, 細菌学若手コロッセウム, Invited

Spiroplasma infection induces male-specific DNA damage response in Drosophila melanogaster
Toshiyuki Harumoto
The 8th International Wolbachia Conference, 10 Jun. 2014

器官のグローバルな非対称性と一細胞の極性を結びつける機構の解明
春本敏之; 島田裕子; 上村匡
第82回日本生化学会大会, 24 Oct. 2009, 日本生化学会, Invited

Atypical cadherins Dachsous and Fat control alignment and polarity of microtubules in planar cell polarity
Toshiyuki Harumoto
The 9th Japan Drosophila Research Conference, 07 Jul. 2009, Japan Drosophila Research Conference

Awards

01 Apr. 2022
Nagase Science and Technology Foundation, Nagase Foundation Award
Japan, Publisher
Toshiyuki Harumoto

04 Feb. 2013
Inoue Foundation for Science, The 29th Inoue Research Award for Young Scientists
Japan, Publisher
Toshiyuki Harumoto

Media Coverage

オス殺しのコストパフォーマンスが高いわけ ―共生細菌の毒素は自己安定化のしくみをもつ―
京都大学大学院生命科学研究科, 27 Sep. 2023, Pr

オス殺しのコストパフォーマンスが高いわけ―共生細菌の毒素は自己安定化のしくみをもつ―
京都大学, 08 Sep. 2023, Pr

Mystery solved: The bacterial protein that kills male fruit flies
École Polytechnique Fédérale de Lausanne, 07 May 2018, Pr

「メスのみ孵化」解明－産総研天敵農薬への応用期待
化学工業日報, 5面（ライフイノベーション）, 26 Sep. 2016, Paper

共生細菌が宿主昆虫をメスだけにするしくみを解明－オスのX染色体を切断して細胞死を引き起こす－
国立研究開発法人産業技術総合研究所, 23 Sep. 2016, Pr

External funds: Kakenhi

液性免疫を司る経路の使い方は個体ごとにゆらぐ？
Grant-in-Aid for Challenging Research (Exploratory)
Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
National Agriculture and Food Research Organization
西出雄大
From 30 Jun. 2022, To 31 Mar. 2024, Granted
昆虫免疫;液性免疫
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19352/

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