Basic Information

Faculty

• 薬学部

Academic Degree

• The master's degree(Kyoto University)
• Ph. D.(Kyoto University)

ID,URL

• J-Global ID

  201501056775075849

researchmap URL

• https://researchmap.jp/7000011411

Research

Research Topics, Overview of the research

• Research Topics

  Basic study and applied research of physiological and pathological functions of Free fatty acid receptors and ion channels.

• Overview of the research

  
  過剰なエネルギー摂取や低酸素といった外部環境に起因する変化や、細胞内の電荷の偏りやpHなどといった、内部環境に起因する細胞レベルの影響まで、生物は日々様々な種類のストレスに晒されています。生命にとってこれらのストレスに応答し、生体内の恒常性を保つための仕組みは非常に重要であり、この機構が破綻すると様々な疾患が引き起こされます。特に、この機構には環境の変化を感知するセンサーが大事な役割を担っており、私はセンサーとなる細胞の受容体の働きを解明することで、これらの異常によって現れる病態を理解し、新たな薬の創出に役立てることを目指しています。

Papers

• Enhanced Ca²⁺ handling in thioglycolate-elicited peritoneal macrophages

  Feng Liu; Luxin Xu; Miyuki Nishi; Atsuhiko Ichimura; Hiroshi Takeshima

  Cell Calcium, Jun. 2021

  
• Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso-Cyclization

  Haruka Takeuchi; Shinsuke Inuki; Kohei Nakagawa; Takaaki Kawabe; Atsuhiko Ichimura; Shinya Oishi; Hiroaki Ohno

  Angewandte Chemie - International Edition, 16 Nov. 2020

  
• Free fatty acid receptors in health and disease

  Ikuo Kimura; Atsuhiko Ichimura; Ryuji Ohue-Kitano; Miki Igarashi

  Physiological Reviews, Jan. 2020, Peer-reviewed

  
• Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

  Junki Miyamoto; Miki Igarashi; Keita Watanabe; Shin ichiro Karaki; Hiromi Mukouyama; Shigenobu Kishino; Xuan Li; Atsuhiko Ichimura; Junichiro Irie; Yukihiko Sugimoto; Tetsuya Mizutani; Tatsuya Sugawara; Takashi Miki; Jun Ogawa; Daniel J. Drucker; Makoto Arita; Hiroshi Itoh; Ikuo Kimura

  Nature Communications, 01 Dec. 2019, Peer-reviewed

  
• TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.

  Nianchao Qian; Atsuhiko Ichimura; Daisuke Takei; Reiko Sakaguchi; Akihiro Kitani; Ryohei Nagaoka; Masato Tomizawa; Yuu Miyazaki; Hitoshi Miyachi; Tomohiro Numata; Sho Kakizawa; Miyuki Nishi; Yasuo Mori; Hiroshi Takeshima

  Science signaling, 09 Apr. 2019, Peer-reviewed

  
• Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation.

  Akiko Kishikawa; Hideki Kitaura; Keisuke Kimura; Saika Ogawa; Jiawei Qi; Wei-Ren Shen; Fumitoshi Ohori; Takahiro Noguchi; Aseel Marahleh; Yasuhiko Nara; Atsuhiko Ichimura; Itaru Mizoguchi

  Frontiers in endocrinology, 2019, Peer-reviewed

  
• Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance.

  Taka-Aki Koshimizu; Kenji Honda; Sachi Nagaoka-Uozumi; Atsuhiko Ichimura; Ikuo Kimura; Michio Nakaya; Nobuya Sakai; Katsushi Shibata; Kentarou Ushijima; Akio Fujimura; Akira Hirasawa; Hitoshi Kurose; Gozoh Tsujimoto; Akito Tanoue; Yukio Takano

  Nature neuroscience, Jun. 2018, Peer-reviewed

  
• Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1.

  Shin-Ichi Kawaguchi; Yuhei Gonda; Takuya Yamamoto; Yuki Sato; Hiroyuki Shinohara; Yohsuke Kobiki; Atsuhiko Ichimura; Takashi Dan; Motohiro Sonoda; Toshio Miyata; Akiya Ogawa; Tadayuki Tsujita

  Molecules (Basel, Switzerland), 11 Apr. 2018, Peer-reviewed

  
• The natural flavonoid myricetin inhibits gastric H+, K+-ATPase.

  Yuu Miyazaki; Atsuhiko Ichimura; Shun Sato; Takuto Fujii; Shinya Oishi; Hideki Sakai; Hiroshi Takeshima

  European journal of pharmacology, 05 Feb. 2018, Peer-reviewed

  
• Gm7325 Transcription Is Regulated by MyoD in Activated Muscle Satellite Cells

  Daisuke Takei; Miyuki Nishi; So-ichiro Fukada; Masao Doi; Hitoshi Okamura; Akiyoshi Uezumi; Lidan Zhang; Morikatsu Yoshida; Mikiya Miyazato; Atsuhiko Ichimura; Hiroshi Takeshima

  Biophysical Journal, Feb. 2018, Peer-reviewed

  
• Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.

  Kumpei Honjo; Shinya Munakata; Yoshihiko Tashiro; Yousef Salama; Hiroshi Shimazu; Salita Eiamboonsert; Douaa Dhahri; Atsuhiko Ichimura; Takashi Dan; Toshio Miyata; Kazuyoshi Takeda; Kazuhiro Sakamoto; Koichi Hattori; Beate Heissig

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jun. 2017, Peer-reviewed

  
• Polymorphic Variation in FFA Receptors: Functions and Consequences.

  Atsuhiko Ichimura

  Handbook of experimental pharmacology, 2017, Peer-reviewed

  
• Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.

  Daisuke Takei; Miyuki Nishi; So-Ichiro Fukada; Masao Doi; Hitoshi Okamura; Akiyoshi Uezumi; Lidan Zhang; Morikatsu Yoshida; Mikiya Miyazato; Atsuhiko Ichimura; Hiroshi Takeshima

  Biomedical research (Tokyo, Japan), 2017, Peer-reviewed

  
• Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.

  Chengzhu Zhao; Atsuhiko Ichimura; Nianchao Qian; Tsunaki Iida; Daiju Yamazaki; Naruto Noma; Masataka Asagiri; Koji Yamamoto; Shinji Komazaki; Chikara Sato; Fumiyo Aoyama; Akira Sawaguchi; Sho Kakizawa; Miyuki Nishi; Hiroshi Takeshima

  Science signaling, 17 May 2016, Peer-reviewed

  
• Nutritional Signaling via Free Fatty Acid Receptors.

  Junki Miyamoto; Sae Hasegawa; Mayu Kasubuchi; Atsuhiko Ichimura; Akira Nakajima; Ikuo Kimura

  International journal of molecular sciences, 25 Mar. 2016, Peer-reviewed

  
• TRIC-B Mutations Causing Osteogenesis Imperfecta.

  Atsuhiko Ichimura; Hiroshi Takeshima

  Biological & pharmaceutical bulletin, 2016, Peer-reviewed

  
• Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.

  Bo Van; Miyuki Nishi; Shinji Komazaki; Atsuhiko Ichimura; Sho Kakizawa; Keita Nakanaga; Junken Aoki; Ki-Ho Park; Jianjie Ma; Tomomi Ueyama; Takehiro Ogata; Naoki Maruyama; Hiroshi Takeshima

  FEBS letters, 28 Apr. 2015, Peer-reviewed

  
• Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation.

  Mayu Kasubuchi; Sae Hasegawa; Takero Hiramatsu; Atsuhiko Ichimura; Ikuo Kimura

  Nutrients, 14 Apr. 2015, Peer-reviewed

  
• Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

  Veronica R Placencio; Atsuhiko Ichimura; Toshio Miyata; Yves A DeClerck

  PloS one, 2015, Peer-reviewed

  
• Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis.

  Nicolas Pelisch; Takashi Dan; Atsuhiko Ichimura; Hiroki Sekiguchi; Douglas E Vaughan; Charles van Ypersele de Strihou; Toshio Miyata

  PloS one, 2015, Peer-reviewed

  
• Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.

  Satsuki Mashiko; Kazuyuki Kitatani; Masafumi Toyoshima; Atsuhiko Ichimura; Takashi Dan; Toshinori Usui; Masumi Ishibashi; Shogo Shigeta; Satoru Nagase; Toshio Miyata; Nobuo Yaegashi

  Cancer biology & therapy, 2015, Peer-reviewed

  
• Editorial: Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors.

  Atsuhiko Ichimura; Ikuo Kimura

  Frontiers in endocrinology, 2015, Peer-reviewed

  
• A novel antidiabetic therapy: free fatty acid receptors as potential drug target.

  Hiroki Sekiguchi; Mayu Kasubuchi; Sae Hasegawa; Nicolas Pelisch; Ikuo Kimura; Atsuhiko Ichimura

  Current diabetes reviews, 2015, Peer-reviewed

  
• Role of free fatty acid receptors in the regulation of energy metabolism.

  Takafumi Hara; Daiji Kashihara; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto; Akira Hirasawa

  Biochimica et biophysica acta, Sep. 2014, Peer-reviewed

  
• Plasminogen activator inhibitor-1 (PAI-1) molecule: new physiological roles and clinical applications.

  Takashi Dan; Atsuhiko Ichimura; Nicolas Pelisch; Kazuhiko Miyata; Koji Akahori; Toshio Miyata

  [Rinsho ketsueki] The Japanese journal of clinical hematology, Apr. 2014

  
• Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors.

  Takafumi Hara; Atsuhiko Ichimura; Akira Hirasawa

  Frontiers in endocrinology, 2014, Peer-reviewed

  
• Regulation of Energy Homeostasis via GPR120.

  Atsuhiko Ichimura; Takafumi Hara; Akira Hirasawa

  Frontiers in endocrinology, 2014, Peer-reviewed

  
• Free fatty acid receptors as therapeutic targets for the treatment of diabetes.

  Atsuhiko Ichimura; Sae Hasegawa; Mayu Kasubuchi; Ikuo Kimura

  Frontiers in pharmacology, 2014, Peer-reviewed

  
• Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence.

  Amanda E Boe; Mesut Eren; Sheila B Murphy; Christine E Kamide; Atsuhiko Ichimura; David Terry; Danielle McAnally; Layton H Smith; Toshio Miyata; Douglas E Vaughan

  Circulation, 19 Nov. 2013, Peer-reviewed

  
• A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

  Atsuhiko Ichimura; Sachiko Matsumoto; Shinobu Suzuki; Takashi Dan; Satoshi Yamaki; Yayoi Sato; Hideyasu Kiyomoto; Naoto Ishii; Kiyotaka Okada; Osamu Matsuo; Fan-Fan Hou; Douglas E Vaughan; Charles van Ypersele de Strihou; Toshio Miyata

  Arteriosclerosis, thrombosis, and vascular biology, May 2013, Peer-reviewed

  
• [Diet-induced obesity and GPR120].

  Atsuhiko Ichimura

  Nihon rinsho. Japanese journal of clinical medicine, Feb. 2013, Peer-reviewed

  
• Free fatty acid receptors and their role in regulation of energy metabolism.

  Takafumi Hara; Ikuo Kimura; Daisuke Inoue; Atsuhiko Ichimura; Akira Hirasawa

  Reviews of physiology, biochemistry and pharmacology, 2013, Peer-reviewed

  
• [Physiological functions of fatty acid receptors and their therapeutic potential].

  Takafumi Hara; Akira Hirasawa; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Dec. 2012, Peer-reviewed

  
• Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats.

  Tadashi Sofue; Hideyasu Kiyomoto; Hiroyuki Kobori; Maki Urushihara; Yoko Nishijima; Kumiko Kaifu; Taiga Hara; Sachiko Matsumoto; Atsuhiko Ichimura; Hiroyuki Ohsaki; Hirofumi Hitomi; Hiroshi Kawachi; Melvin R Hayden; Adam Whaley-Connell; James R Sowers; Sadayoshi Ito; Masakazu Kohno; Akira Nishiyama

  American journal of hypertension, May 2012, Peer-reviewed

  
• Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.

  Atsuhiko Ichimura; Akira Hirasawa; Odile Poulain-Godefroy; Amélie Bonnefond; Takafumi Hara; Loïc Yengo; Ikuo Kimura; Audrey Leloire; Ning Liu; Keiko Iida; Hélène Choquet; Philippe Besnard; Cécile Lecoeur; Sidonie Vivequin; Kumiko Ayukawa; Masato Takeuchi; Kentaro Ozawa; Maithé Tauber; Claudio Maffeis; Anita Morandi; Raffaella Buzzetti; Paul Elliott; Anneli Pouta; Marjo-Riitta Jarvelin; Antje Körner; Wieland Kiess; Marie Pigeyre; Roberto Caiazzo; Wim Van Hul; Luc Van Gaal; Fritz Horber; Beverley Balkau; Claire Lévy-Marchal; Konstantinos Rouskas; Anastasia Kouvatsi; Johannes Hebebrand; Anke Hinney; Andre Scherag; François Pattou; David Meyre; Taka-aki Koshimizu; Isabelle Wolowczuk; Gozoh Tsujimoto; Philippe Froguel

  Nature, 19 Feb. 2012, Peer-reviewed

  
• Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders.

  Takafumi Hara; Akira Hirasawa; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto

  Journal of pharmaceutical sciences, Sep. 2011, Peer-reviewed

  
• Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).

  Ikuo Kimura; Daisuke Inoue; Takeshi Maeda; Takafumi Hara; Atsuhiko Ichimura; Satoshi Miyauchi; Makio Kobayashi; Akira Hirasawa; Gozoh Tsujimoto

  Proceedings of the National Academy of Sciences of the United States of America, 10 May 2011, Peer-reviewed

  
• miRNAs and regulation of cell signaling.

  Atsuhiko Ichimura; Yoshinao Ruike; Kazuya Terasawa; Gozoh Tsujimoto

  The FEBS journal, May 2011, Peer-reviewed

  
• [Free fatty acid receptors and their physiological role in metabolic regulation].

  Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Gozoh Tsujimoto

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Peer-reviewed

  
• MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells.

  Atsuhiko Ichimura; Yoshinao Ruike; Kazuya Terasawa; Kazuharu Shimizu; Gozoh Tsujimoto

  Molecular pharmacology, Jun. 2010, Peer-reviewed

  
• New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract.

  Satoshi Miyauchi; Akira Hirasawa; Atsuhiko Ichimura; Takafumi Hara; Gozoh Tsujimoto

  Journal of pharmacological sciences, 2010, Peer-reviewed

  
• Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.

  Atsuhiko Ichimura; Akira Hirasawa; Takafumi Hara; Gozoh Tsujimoto

  Prostaglandins & other lipid mediators, Sep. 2009, Peer-reviewed

  
• Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells.

  Kazuya Terasawa; Atsuhiko Ichimura; Fumiaki Sato; Kazuharu Shimizu; Gozoh Tsujimoto

  The FEBS journal, Jun. 2009, Peer-reviewed

  
• In silico approach to identify the expression of the undiscovered molecules from microarray public database: identification of odorant receptors expressed in non-olfactory tissues.

  Atsuhiko Ichimura; Tadashi Kadowaki; Kayo Narukawa; Kayo Togiya; Akira Hirasawa; Gozoh Tsujimoto

  Naunyn-Schmiedeberg's archives of pharmacology, Apr. 2008, Peer-reviewed

  
• Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines.

  Yoshinao Ruike; Atsuhiko Ichimura; Soken Tsuchiya; Kazuharu Shimizu; Ryo Kunimoto; Yasushi Okuno; Gozoh Tsujimoto

  Journal of human genetics, 2008, Peer-reviewed

  

Misc.

• 軟骨細胞における細胞内Ca2+制御機構と生理機能の解析

  市村 敦彦

  日本応用酵素協会誌, Mar. 2021

  
• 膜タンパク質の生理機能解明に基づく新規薬物標的候補分子の同定

  市村 敦彦

  日本薬学会年会要旨集, Mar. 2020

  
• カウンターイオンチャネルTRIC-Bの欠損はマウス成長板軟骨細胞において形態異常を引き起こす

  宮崎 侑; 市村 敦彦; 北山 諒; 辻本 真人; 山崎 大樹; 西 美幸; 竹島 浩

  日本薬学会年会要旨集, Mar. 2020

  
• Physiological functions of GPCRs sensing Long-chain Free Fatty Acids

  Ichimura Atsuhiko

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020

  
• 軟骨細胞におけるCa2+動態の分子機構及び生理機能の解明

  市村 敦彦

  日本応用酵素協会誌, Mar. 2019

  
• 小胞体カウンターイオンチャネルTRIC-Bの骨形成不全症における病態生理学的解析

  市村 敦彦

  日本応用酵素協会誌, Mar. 2018

  
• 天然フラボノイドミリセチンは胃のH+、K+-ATPaseを抑制する

  宮崎 侑; 市村 敦彦; 佐藤 駿; 藤井 拓人; 大石 真也; 酒井 秀紀; 竹島 浩

  日本薬学会年会要旨集, Mar. 2018

  
• 新規PAI-1阻害剤はマウス骨髄除去モデルにおいて骨形成を促進する

  Aobulikasimu Alkebaier; 金 光文; 朴 金瑛; Zulipiya Aibibula; 段 孝; 市村 敦彦; 宮田 敏男; 越智 広樹; 佐藤 信吾; 大川 淳; 麻生 義則

  日本整形外科学会雑誌, Aug. 2017

  
• 新規PAI-1阻害薬は閉経後骨粗鬆症モデルの骨密度を回復させる

  金 光文; 朴 英瑛; Aobulikasimu Alkebaier; Zulipiya Aibibula; 段 孝; 市村 敦彦; 赤堀 浩司; 宮田 敏男; 越智 広樹; 佐藤 信吾; 大川 淳; 麻生 義則

  日本整形外科学会雑誌, Aug. 2017

  
• 活性化した筋衛星細胞におけるMyoD依存的なGm7325遺伝子の発現

  武井大祐; 西美幸; 深田宗一朗; 土居雅夫; 岡村均; 上住聡芳; 吉田守克; 宮里幹也; 市村敦彦; 市村敦彦; 竹島浩

  日本筋学会学術集会プログラム・抄録集, Jul. 2017

  
• 小胞体カウンターイオンチャネルTRIC-Bの骨形成不全症における病態生理学的解析

  市村 敦彦

  日本応用酵素協会誌, Mar. 2017

  
• 病理学 TRIC-B遺伝子変異による骨形成不全症

  市村 敦彦; 趙 成珠; 竹島 浩

  医学のあゆみ, Feb. 2017

  
• 生物系薬学 Pitx2は抗酸化応答の活性化によって傷害後の心臓修復を促進する

  市村 敦彦

  ファルマシア, Jan. 2017

  
• Physiological function of short-chain fatty acid receptor under ketogenic condition

  Mayu Kasubuchi; Sae Hasegawa; Atsuhiko Ichimura; Ikuo Kimura

  FASEB JOURNAL, Apr. 2016

  
• TRIC-Bチャネルの骨形成と破骨細胞における生理機能の解析

  銭 年超; 市村 敦彦; 朝霧 成挙; 竹島 浩

  日本薬学会年会要旨集, Mar. 2016

  
• TRIC-Bチャネルの骨形成と骨芽細胞における生理機能の解析

  趙 成珠; 市村 敦彦; 山本 浩司; 竹島 浩

  日本薬学会年会要旨集, Mar. 2016

  
• 腹腔内癒着における線溶系阻害因子PAI-1の機能解明

  宗像 慎也; 本庄 薫平; 島津 浩; 田代 良彦; 市村 敦彦; 段 孝; 宮田 敏男; Heissig Beate; 服部 浩一; 坂本 一博

  日本消化器外科学会総会, Jul. 2015

  
• 下部消化管 腹腔内癒着における線溶系阻害因子PAI-1の機能解明

  本庄 薫平; 塚本 亮一; 植山 孝恵; 伊藤 慎吾; 市川 亮介; 呉 一眞; 盧 尚志; 田代 良彦; 宗像 慎也; 高橋 玄; 小見山 博光; 小島 豊; 五藤 倫敏; 冨木 裕一; 市村 敦彦; 段 孝; 宮田 敏男; Heissig Beate; 服部 浩一; 坂本 一博

  日本外科学会定期学術集会抄録集, Apr. 2015

  
• Plasminogen activator inhibitor-1(PAI-1)分子 新たな生理的役割と臨床応用

  段 孝; 市村 敦彦; ニコラス・ペリッシュ; 宮田 和彦; 赤堀 浩司; 宮田 敏男

  臨床血液, Apr. 2014

  
• Lactose intolerance and the free fatty acid binding G-protein coupled receptors

  須山 享三; 市村 敦彦

  乳業技術, 2014

  
• 【CKDと血栓】 CKDと抗血栓療法 CKDにおける抗血栓療法の新たな展開

  段 孝; 市村 敦彦; 宮田 敏男

  血栓と循環, Aug. 2013

  
• The clinical application of PAI-1 inhibitor

  ICHIMURA Atsuhiko; DAN Takashi; MIYATA Toshio

  Japanese Journal of Thrombosis and Hemostasis, Aug. 2013

  
• Diet-induced obesity and GPR120

  市村 敦彦

  日本臨床, Feb. 2013

  
• Physiological functions of fatty acid receptors and their therapeutic potential

  HARA Takafumi; HIRASAWA Akira; ICHIMURA Atsuhiko; KIMURA Ikuo; TSUJIMOTO Gozoh

  Folia Pharmacologica Japonica, 01 Dec. 2012

  
• 【CKDと脳心血管疾患との密接な関連を読み解く】 脳心腎連関における危険因子の関与 血管老化の関与 AGEを中心に

  段 孝; 市村 敦彦; 松本 幸子; 宮田 敏男

  Circulation, May 2012

  
• 糸球体障害におけるポドサイトの役割と新規Plasminogen activator inhibitor(PAI)-1阻害薬TM5275の効果

  松本 幸子; 清元 秀泰; 市村 敦彦; 中道 崇; 段 孝; 森 建文; 伊藤 貞嘉; 宮田 敏男

  日本腎臓学会誌, Apr. 2012

  
• The alteration of insaturated fatty acid receptors of type-omega-3 GPR120 leads to obesity in Men and Mice

  A. Bonnefond; O. Poulain-Godefroy; A. Ichimura; A. Hirasawa; L. Yengo; A. Leloire; H. Choquet; D. Meyre; F. Pattou; I. Wolowczuk; G. Tsujimoto; P. Froguel

  DIABETES & METABOLISM, Mar. 2012

  
• Free Fatty Acid Receptors as drug targets : Cardiovascular disease and metabolic syndrome

  ICHIMURA Atsuhiko

  血管, 31 Dec. 2011

  
• 栄養素センサー研究の新展開 長寿健康社会のための栄養薬学(Nutritional Pharmacy) 消化管脂肪酸受容体の生理作用

  平澤 明; 原 貴史; 市村 敦彦; 宮内 諭; 辻本 豪三

  日本薬学会年会要旨集, Mar. 2011

  
• 脂肪酸受容体GPR120機能不全は食餌誘発性の肥満及び脂肪肝を惹起する

  市村 敦彦; 平澤 明; 宮内 諭; 木村 郁夫; 鮎川 公美子; 竹内 理人; 辻本 豪三

  血管, Jan. 2011

  
• Free Fatty Acid Receptors and Their Physiological Role in Metabolic Regulation

  HIRASAWA Akira; HARA Takafumi; ICHIMURA Atsuhiko; TSUJIMOTO Gozoh

  YAKUGAKU ZASSHI, 2011

  
• Relation between free fatty acid receptor and metabolic syndrome

  KIMURA Ikuo; INOUE Daisuke; MAEDA Takeshi; MIYAUCHI Satoshi; ICHIMURA Atsuhiko; HIRASAWA Akira; TSUJIMOTO Gozoh

  血管, 28 Oct. 2010

  
• GPR120の遺伝子多型(Arg67Cys)と2型糖尿病の関連の検討

  村上 智史; 永瀬 晃正; 三井 雅子; 鮎川 公美子; 市村 敦彦; 孫 き; 平澤 明; 辻本 豪三; 桂 善也

  糖尿病, Apr. 2010

  
• 短鎖脂肪酸受容体GPR41の生体における発現解析

  井上 大輔; 木村 郁夫; 前田 岳志; 宮内 諭; 市村 敦彦; 平澤 明; 辻本 豪三

  日本薬理学雑誌, Mar. 2010

  
• ヒトGPR120遺伝子多型の機能解析

  鮎川 公美子; 市村 敦彦; 孫 き; 村上 智史; 永瀬 晃正; 平澤 明; 辻本 豪三

  日本薬学会年会要旨集, Mar. 2010

  
• Novel function of long-chain free fatty acid receptor GPR120

  Gozoh Tsujimoto; Akira Hirasawa; Atsuhiko Ichimura

  ENDOCRINE JOURNAL, Mar. 2010

  
• 短鎖脂肪酸受容体の交感神経を介した循環器系機能へ及ぼす影響

  木村 郁夫; 井上 大輔; 前田 岳志; 宮内 諭; 市村 敦彦; 平澤 明; 辻本 豪三

  血管, Jan. 2010

  
• Role of free fatty acid receptor GPR120 in metabolic regulation

  Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Satoshi Miyauchi; Ikuo Kimura; Koshimizu Taka-aki; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  
• Fat sensing in the gut

  Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Ning Liu; Keiko Iida; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• 公共マイクロアレイデータベースを用いたマウス嗅覚受容体のIn Silico発現分布

  市村敦彦; 門脇正史; 研谷佳代; 生川佳代; 平澤明; 辻本豪三

  日本薬理学雑誌, Aug. 2006

  

Presentations

• Novel physiological functions of free fatty acid receptors

  Atsuhiko Ichimura

  第94回日本薬理学会年会, 10 Mar. 2021, Invited

  
• カウンターイオンチャネルTRIC-Bの欠損はマウス成長板軟骨細胞において形態異常を引き起こす

  宮崎 侑; 市村 敦彦; 北山 諒; 辻本 真人; 山崎 大樹; 西 美幸; 竹島 浩

  第140回 日本薬学会年会, 28 Mar. 2020

  
• 膜タンパク質の生理機能解明に基づく新規薬物標的候補分子の同定

  市村 敦彦

  第140回 日本薬学会年会, 26 Mar. 2020, Invited

  
• Physiological functions of GPCRs sensing Long-chain Free Fatty Acids

  Atsuhiko Ichimura

  第93回 薬理学会年会, 16 Mar. 2020, Invited

  
• Regulation of intracellular Ca2+ and bone formation

  Atsuhiko Ichimura

  15th Retreat of “Regeneration Medicine and Organ Reconstruction, 19 Oct. 2019, Invited

  
• フラボノイドミリセチンは胃のH+, K+-ATPaseを抑制する

  宮崎侑; 市村敦彦; 佐藤駿; 藤井拓人; 大石真也; 酒井秀紀; 竹島浩

  日本薬学会 第138回年会, 26 Mar. 2018

  
• Spontaneous Ca2+ fluctuations mediated by TRPM7 channels in growth plate chondrocytes

  Nianchao Qian; Atsuhiko Ichimura; Daisuke Takei; Hua Zhu; Miyuki Nishi; Hiroshi Takeshima

  Biophysical society 62nd Annual Meeting, Feb. 2018

  
• 細胞のストレス応答機構を解き明かす―細胞はストレスにどう対処するのか？

  市村 敦彦

  産学間知識交流（ファーストコンタクト）プログラム KRPアイデア・シェアリング・コミュニティ（KRP-ISC）, 07 Mar. 2017, Invited

  
• TRIC-B チャネルの骨形成と破骨細胞における生理機能の解析

  銭年超; 市村敦彦; 朝霧成挙; 竹島浩

  日本薬学会 第136年会, Mar. 2017

  
• TRIC-Bチャネルの骨形成と骨芽細胞における生理機能の解析

  趙成珠; 市村敦彦; 山本浩司; 竹島浩

  日本薬学会 第136年会, Mar. 2017

  
• Compromised Collagen Production in Tric-b-knockout Osteoblast

  Chengzhu Zhao; Nianchao Qian; Atsuhiko Ichimura; Daiju Yamazaki; Masataka Asagiri; Koji Yamamoto; Shinji Komazaki; Miyuki Nishi; Hiroshi Takeshima

  Biophysical society 60th Annual Meeting, Feb. 2017

  
• ストレスに適応する生体恒常性の制御機構の解明と創薬応用

  市村 敦彦

  京都大学学祭融合教育研究推進センター 生理化学研究ユニット 第5回シンポジウム, 25 Dec. 2016

  
• Regulation of energy homeostasis via GPR120/FFAR4: A receptor for long chain fatty acids

  Atsuhiko Ichimura

  特別セミナー「生命創薬科学の最前線」, May 2015, Invited

  
• Drug deveropment of Plasminogen Activator Inhibitor-1 inhibior; a novel candidate of anti-inflammatory drug

  Atsuhiko Ichimura

  第37 回日本血栓止血学会学術集会, May 2015, Invited

  
• Regulation of energy homeostasis via GPR120/FFAR4: A receptor for long chain fatty acids

  Atsuhiko Ichimura

  第48 回日本味と匂学会大会, Oct. 2014, Invited

  
• A plasminogen activator inhibitor (PAI)-1 inhibitor attenuates high fat diet induced obesity and improves glucose metabolism

  Atsuhiko Ichimura

  ISI Nexus Symposium, Apr. 2014

  
• A small molecule inhibitor to plasminogen activator inhibitor (PAI)-1 inhibits macrophage migration and attenuates renal injury

  Atsuhiko Ichimura

  ISI Nexus Symposium, Apr. 2014

  
• A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration

  Atsuhiko Ichimura

  NIH-Tohoku University-JSPS国際シンポジウム, May 2013

  
• Generation of Glyoxalase 1-deficient mouse

  Atsuhiko Ichimura

  11th International Symposium on the Maillard Reaction, Sep. 2012

  
• GLO1欠損マウスの創出

  市村敦彦; 段孝; 宮田敏男

  第21回日本メイラード学会年会, Nov. 2011

  
• 脂肪酸受容体GPR120機能不全は食餌誘発性の肥満及び脂肪肝を惹起する

  市村 敦彦; 平澤 明; 宮内 諭; 木村 郁夫; 鮎川 公美子; 竹内 理人; 辻本 豪三

  第40回日本心脈管作動物質学会, Feb. 2011

  
• GPR120 mediates high-fat diet-induced adipocyte hypertrophy and obesity

  Atsuhiko Ichimura; Akira Hirasawa; Satoshi Miyauchi; Gozoh Tsujimoto

  WorldPharma 2010, Jul. 2010

  
• GPR120 mediate high-fat diet-induced adipocyte hypertrophy and obesity

  Atsuhiko Ichimura

  第32回日本分子生物学会年会, Dec. 2009

  
• 慢性骨髄性白血病細胞株K562においてTPA刺激により誘導されるmiRNAおよび標的遺伝子探索

  市村 敦彦; 類家 慶直; 寺澤 和哉; 辻本 豪三

  BMB2007 (第30回日本分子生物学会年会・第80回日本生化学会大会合同大会), Dec. 2007

  
• 公共マイクロアレイデータベースを用いたマウス嗅覚受容体のIn Silico発現分布

  市村 敦彦; 門脇 正史; 平澤 明; 辻本 豪三

  第109回日本薬理学会近畿部会, Jun. 2006

  

Awards

• 05 Feb. 2011

  Japanese society for Circulation Reserch, Young Investigator’s Award
• 28 Oct. 2011

  Japanese Maillard Reaction Society, Young Investigator's Award
• 25 Mar. 2020

  The Pharmaceutical Society of Japan, The Pharmaceutical Society of Japan Award for Young Scientists

External funds: Kakenhi

• 軟骨細胞内Ca2+を通じた新規骨伸長促進法と骨系統疾患治療法の探索

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields

  Kyoto University

  市村 敦彦

  From 09 Jul. 2021, To 31 Mar. 2023, Granted

  細胞内カルシウム;軟骨細胞;骨伸長;C型ナトリウム利尿ペプチド;スクリーニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19565/
• 軟骨内骨化における細胞内Ca2+制御機構の解明と骨関連疾患への応用

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Kyoto University

  市村 敦彦

  From 01 Apr. 2020, To 31 Mar. 2023, Granted

  細胞内Ca2+;軟骨内骨化;骨関連疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03802/
• 胎児期軟骨組織カルシウムシグナルマッピング

  Grant-in-Aid for Scientific Research (C)

  Basic Section 59040:Nutrition science and health science-related

  Kyoto University

  武井 大祐

  From 01 Apr. 2018, To 31 Mar. 2019, Discontinued

  カルシウムシグナル;軟骨組織;生理学;イメージング;マッピング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K11044/
• Analyses of regulatory mechanisms of energy homeostasis via free fatty acids receptors

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  Ichimura Atsuhiko

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  脂肪酸;受容体;GPCR;エネルギー代謝;肥満;糖尿病;脂肪酸受容体;遊離脂肪酸;生体分子;薬理学;薬学;脂質;ゲノム;ゲノム薬理学;分子薬理学;遺伝子多型;代謝異常;栄養学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05652/
• Molecular pharmacological analysis of anti-inflammatory effects of PAI-1 inhibitor

  Grant-in-Aid for Young Scientists (B)

  Kyoto University;Tohoku University

  Ichimura ATSUHIKO

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  分子薬理学;創薬;炎症;薬理学;糖尿病;肥満;代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860185/
• The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseases

  Grant-in-Aid for Scientific Research (A)

  Tohoku University

  Toshio MIYATA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  薬理学;生理活性;生体分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24249033/
• The analysis of molecular mechanisms of the inflammatory macrophage migration by using a small molecule inhibitor to plasminogen activator inhibitor 1.

  Grant-in-Aid for Research Activity Start-up

  Tohoku University

  Atsuhiko ICHIMURA

  From 24 Aug. 2011, To 31 Mar. 2013, Project Closed

  薬理学;免疫学;炎症;マクロファージ;PAI-1;免疫細胞遊走;抗炎症;線溶系

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23890019/

External funds: others

• PAI-1 阻害薬を用いた新規CKD-CVD-MBD 改善薬の開発

  JST 復興促進プログラム (A-STEP) 探索タイプ

  From 01 Apr. 2012, To 31 Mar. 2013

  代表
• ゲノム薬理学、バイオマーカーを用いた医薬品の有効性・安全性に関する評価方法

  医薬品等審査迅速化事業費補助金 革新的医薬品・医療機器・再生医療製品実用化促進事業

  From 01 Apr. 2012, To 31 Mar. 2015

  分担
• 健康寿命の延伸、重症化遅延を目指した早老症治療薬の創出

  厚生労働科学研究委託業務(難治性疾患等克服研究事業(難治性疾患等実用化研究事業(難治性疾 患実用化研究事業)

  From 01 Oct. 2014, To 31 Mar. 2016

  分担
• 新規作用機序の多発性硬化症治療薬の開発

  厚生労働科学研究委託業務(難治性疾患等克服研究事業(難治性疾患等実用化研究事業(難治性疾 患実用化研究事業)

  From 01 Oct. 2014, To 31 Mar. 2016

  分担

Education

Teaching subject(s)

• From Apr. 2018, To Mar. 2019

  Global Frontier in Life Science A

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Fundamental Chemical Experiments

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Introduction to Biomedical Sciences

  Spring, 全学共通科目