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Nakano, Masahiro

Institute for Life and Medical Sciences (LiMe) Assistant Professor

Nakano, Masahiro
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    Last Updated :2023/05/27

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Biostudies, 統合生命科学専攻 微細構造ウイルス学, 助教

    Academic Degree

    • 修士(農学)(九州大学)
    • 博士(農学)(九州大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2023/05/27

      Research

      Research Topics, Overview of the research

      • Research Topics

        インフルエンザウイルスのゲノム転写・複製機構の解明
      • Overview of the research

        インフルエンザウイルスのゲノムRNAは、核タンパク質NPやポリメラーゼとともにvRNPを形成する。vRNPはmRNA合成(転写)およびcRNA合成(複製の第一段階)を担う。ウイルス粒子から精製したvRNPは、柔軟な二重らせん構造を持つことが近年の電子顕微鏡解析より明らかとなっている。しかし、mRNAあるいはcRNA合成中のvRNPの構造については全く解明されておらず、また、これらのRNAがどのようにして合成されるのかも分かっていない。そこで私は、高速原子間力顕微鏡(AFM)を用いて機能的な状態のvRNPを解析することによって、微細構造学的観点からインフルエンザウイルスのゲノム転写・複製機構を明らかにすることを目的として研究を行っている。

      Research Areas

      • Life sciences, Molecular biology
      • Life sciences, Virology

      Papers

      • Cryo-electron microscopic structure of the nucleoprotein-RNA complex of the European filovirus, Lloviu virus
        Shangfan Hu; Yoko Fujita-Fujiharu; Yukihiko Sugita; Lisa Wendt; Yukiko Muramoto; Masahiro Nakano; Thomas Hoenen; Takeshi Noda
        PNAS Nexus, 06 Apr. 2023
      • Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids.
        Rina Hashimoto; Tomokazu Tamura; Yukio Watanabe; Ayaka Sakamoto; Naoko Yasuhara; Hayato Ito; Masahiro Nakano; Hiromitsu Fuse; Akira Ohta; Takeshi Noda; Yasufumi Matsumura; Miki Nagao; Takuya Yamamoto; Takasuke Fukuhara; Kazuo Takayama
        Molecular pharmaceutics, 03 Apr. 2023
      • Migration of Influenza Virus Nucleoprotein into the Nucleolus Is Essential for Ribonucleoprotein Complex Formation
        Sho Miyamoto; Masahiro Nakano; Takeshi Morikawa; Ai Hirabayashi; Ryoma Tamura; Yoko Fujita-Fujiharu; Nanami Hirose; Yukiko Muramoto; Takeshi Noda; Rachel Fearns
        mBio, 22 Feb. 2022
      • Automated amplification-free digital RNA detection platform for rapid and sensitive SARS-CoV-2 diagnosis.
        Hajime Shinoda; Tatsuya Iida; Asami Makino; Mami Yoshimura; Junichiro Ishikawa; Jun Ando; Kazue Murai; Katsumi Sugiyama; Yukiko Muramoto; Masahiro Nakano; Kotaro Kiga; Longzhu Cui; Osamu Nureki; Hiroaki Takeuchi; Takeshi Noda; Hiroshi Nishimasu; Rikiya Watanabe
        Communications biology, 26 May 2022
      • Contribution of RNA-RNA Interactions Mediated by the Genome Packaging Signals for the Selective Genome Packaging of Influenza A Virus.
        Sho Miyamoto; Yukiko Muramoto; Keiko Shindo; Yoko Fujita-Fujiharu; Takeshi Morikawa; Ryoma Tamura; Jamie L Gilmore; Masahiro Nakano; Takeshi Noda
        Journal of virology, 23 Mar. 2022
      • Structural insight into Marburg virus nucleoprotein-RNA complex formation.
        Yoko Fujita-Fujiharu; Yukihiko Sugita; Yuki Takamatsu; Kazuya Houri; Manabu Igarashi; Yukiko Muramoto; Masahiro Nakano; Yugo Tsunoda; Ichiro Taniguchi; Stephan Becker; Takeshi Noda
        Nature communications, 04 Mar. 2022
      • CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor
        Toru Takenaga; Zihan Zhang; Yukiko Muramoto; Sarah Katharina Fehling; Ai Hirabayashi; Yuki Takamatsu; Junichi Kajikawa; Sho Miyamoto; Masahiro Nakano; Shuzo Urata; Allison Groseth; Thomas Strecker; Takeshi Noda
        Viruses, 03 Sep. 2021, Peer-reviewed
      • Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.
        Dai Hatakeyama; Masaki Shoji; Seiryo Ogata; Takeshi Masuda; Masahiro Nakano; Tsugunori Komatsu; Ayaka Saitoh; Kyoko Makiyama; Hazuki Tsuneishi; Asuka Miyatake; Mizuki Takahira; Erina Nishikawa; Ayana Ohkubo; Takeshi Noda; Yoshihiro Kawaoka; Sumio Ohtsuki; Takashi Kuzuhara
        The FEBS journal, 16 Jul. 2021, Peer-reviewed
      • Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis.
        Masahiro Nakano; Yukihiko Sugita; Noriyuki Kodera; Sho Miyamoto; Yukiko Muramoto; Matthias Wolf; Takeshi Noda
        Communications biology, 09 Jul. 2021, Peer-reviewed
      • Amplification-free RNA detection with CRISPR-Cas13.
        Hajime Shinoda; Yuya Taguchi; Ryoya Nakagawa; Asami Makino; Sae Okazaki; Masahiro Nakano; Yukiko Muramoto; Chiharu Takahashi; Ikuko Takahashi; Jun Ando; Takeshi Noda; Osamu Nureki; Hiroshi Nishimasu; Rikiya Watanabe
        Communications biology, 19 Apr. 2021, Peer-reviewed
      • Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis.
        Mahima Sharma; Palika Abayakoon; Ruwan Epa; Yi Jin; James P Lingford; Tomohiro Shimada; Masahiro Nakano; Janice W-Y Mui; Akira Ishihama; Ethan D Goddard-Borger; Gideon J Davies; Spencer J Williams
        ACS central science, 24 Mar. 2021, Peer-reviewed
      • Influenza virus ribonucleoprotein complex formation occurs in the nucleolus
        Sho Miyamoto; Masahiro Nakano; Takeshi Morikawa; Ai Hirabayashi; Ryoma Tamura; Yoko Fujita; Nanami Hirose; Yukiko Muramoto; Takeshi Noda
        24 Feb. 2021
      • Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner.
        Tim Wai Sha; Michaela Weber; Dacquin M Kasumba; Takeshi Noda; Masahiro Nakano; Hiroki Kato; Takashi Fujita
        Virology journal, 16 Jul. 2020, Peer-reviewed
      • vRNA-vRNA interactions in influenza A virus HA vRNA packaging
        Sho Miyamoto; Yukiko Muramoto; Keiko Shindo; Yoko Fujita; Takeshi Morikawa; Ryoma Tamura; Jamie L Gilmore; Masahiro Nakano; Takeshi Noda
        16 Jan. 2020
      • Microtubule-dependent transport of arenavirus matrix protein demonstrated using live-cell imaging microscopy.
        Yuki Takamatsu; Junichi Kajikawa; Yukiko Muramoto; Masahiro Nakano; Takeshi Noda
        Microscopy (Oxford, England), 03 Dec. 2019, Peer-reviewed
      • Generation of a purely clonal defective interfering influenza virus.
        Yutaro Yamagata; Yukiko Muramoto; Sho Miyamoto; Keiko Shindo; Masahiro Nakano; Takeshi Noda
        Microbiology and immunology, May 2019, Peer-reviewed
      • Regulatory role of CsqR (YihW) in transcription of the genes for catabolism of the anionic sugar sulfoquinovose (SQ) in Escherichia coli K-12.
        Tomohiro Shimada; Kaneyoshi Yamamoto; Masahiro Nakano; Hiroki Watanabe; David Schleheck; Akira Ishihama
        Microbiology (Reading, England), Jan. 2019, Peer-reviewed
      • Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5.
        Dai Hatakeyama; Masaki Shoji; Seiya Yamayoshi; Rina Yoh; Naho Ohmi; Shiori Takenaka; Ayaka Saitoh; Yumie Arakaki; Aki Masuda; Tsugunori Komatsu; Rina Nagano; Masahiro Nakano; Takeshi Noda; Yoshihiro Kawaoka; Takashi Kuzuhara
        The Journal of biological chemistry, 11 May 2018, Peer-reviewed
      • A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation.
        Hirotaka Sugino; Takanori Usui; Tomohiro Shimada; Masahiro Nakano; Hiroshi Ogasawara; Akira Ishihama; Akira Hirata
        FEBS letters, Jul. 2017, Peer-reviewed
      • Differential Regulation of rRNA and tRNA Transcription from the rRNA-tRNA Composite Operon in Escherichia coli.
        Hiraku Takada; Tomohiro Shimada; Debashish Dey; M Zuhaib Quyyum; Masahiro Nakano; Akira Ishiguro; Hideji Yoshida; Kaneyoshi Yamamoto; Ranjan Sen; Akira Ishihama
        PloS one, 2016, Peer-reviewed
      • Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli
        Kaneyoshi Yamamoto; Masahiro Nakano; Akira Ishiharna
        MICROBIOLOGY-SGM, Jan. 2015, Peer-reviewed
      • Amyloid-like Conformation and Interaction for the Self-Assembly in Barnacle Underwater Cement
        Masahiro Nakano; Kei Kamino
        BIOCHEMISTRY, Jan. 2015, Peer-reviewed
      • A Novel Functional Site in the PB2 Subunit of Influenza A Virus Essential for Acetyl-CoA Interaction, RNA Polymerase Activity, and Viral Replication
        Dai Hatakeyama; Masaki Shoji; Seiya Yamayoshi; Takenori Hirota; Monami Nagae; Shin Yanagisawa; Masahiro Nakano; Naho Ohmi; Takeshi Noda; Yoshihiro Kawaoka; Takashi Kuzuhara
        JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2014, Peer-reviewed
      • Involvement of cAMP-CRP in transcription activation and repression of the pck gene encoding PEP carboxykinase, the key enzyme of gluconeogenesis.
        Masahiro Nakano; Hiroshi Ogasawara; Tomohiro Shimada; Kaneyoshi Yamamoto; Akira Ishihama
        FEMS microbiology letters, Jun. 2014, Peer-reviewed
      • A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli.
        Tomohiro Shimada; Yasunori Katayama; Shuichi Kawakita; Hiroshi Ogasawara; Masahiro Nakano; Kaneyoshi Yamamoto; Akira Ishihama
        MicrobiologyOpen, Dec. 2012, Peer-reviewed
      • Significance of the conformation of building blocks in curing of barnacle underwater adhesive
        Kei Kamino; Masahiro Nakano; Satoru Kanai
        FEBS JOURNAL, May 2012, Peer-reviewed
      • Single molecule analysis of transcription factor-DNA complexes using atomic force microscopy
        Masahiro Nakano; Jun Teramoto; Tomohiro Shimada; Kaneyoshi Yamamoto; Akira Ishihama
        2011 Int. Symp. on Micro-NanoMechatronics and Human Science, Symp. on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "Hyper Bio Assembler for 3D Cellular System Innovation", 2012, Peer-reviewed
      • Calcite-specific coupling protein in barnacle underwater cement.
        Youichi Mori; Youhei Urushida; Masahiro Nakano; Susumu Uchiyama; Kei Kamino
        The FEBS journal, Dec. 2007, Peer-reviewed
      • Identification and functional characterization of a novel barnacle cement protein.
        Youhei Urushida; Masahiro Nakano; Satoru Matsuda; Naoko Inoue; Satoru Kanai; Naho Kitamura; Takashi Nishino; Kei Kamino
        The FEBS journal, Aug. 2007, Peer-reviewed
      • Self-assembling peptide inspired by a barnacle underwater adhesive protein.
        Masahiro Nakano; Jian-Ren Shen; Kei Kamino
        Biomacromolecules, Jun. 2007, Peer-reviewed
      • Characterization of functional domains of the hemolytic lectin CEL-III from the marine invertebrate Cucumaria echinata.
        Yoshiaki Kouzuma; Yota Suzuki; Masahiro Nakano; Kayo Matsuyama; Sumiki Tojo; Makoto Kimura; Takayuki Yamasaki; Haruhiko Aoyagi; Tomomitsu Hatakeyama
        Journal of biochemistry, Sep. 2003, Peer-reviewed

      Misc.

      • Acetylation on the nucleoprotein of influenza A virus
        D. Hatakeyama; M. Shoji; R. Yoh; N. Ohmi; S. Takenaka; S. Yamayoshi; Y. Arakaki; T. Komatsu; A. Masuda; M. Nakano; T. Noda; Y. Kawaoka; T. Kuzuhara
        FEBS JOURNAL, Jul. 2015
      • Estrogen Receptor Agonist Inhibits Lassa Virus Entry
        張子涵; 張子涵; 張子涵; 武長徹; 武長徹; 武長徹; 村本裕紀子; 村本裕紀子; 村本裕紀子; SARAH Katharina Fehling; 平林愛; 平林愛; 平林愛; 高松由基; 梶川純一; 梶川純一; 梶川純一; 宮本翔; 中野雅博; 中野雅博; 中野雅博; 浦田秀造; ALLISON Groseth; ALLISON Groseth; THOMAS Strecker; 野田岳志; 野田岳志; 野田岳志
        日本ウイルス学会学術集会プログラム・予稿集(Web), 2021
      • Avoidance of cell death in LCMV-infected cells by induction of autophagy
        梶川純一; 梶川純一; 平林愛; 宮本翔; 高松由基; 高松由基; 胡上帆; 胡上帆; 野澤孝志; 中川一路; 浦田秀造; 浦田秀造; 安田二朗; 安田二朗; 遊佐宏介; 中野雅博; 中野雅博; 村本裕紀子; 村本裕紀子; 野田岳志; 野田岳志
        日本ウイルス学会学術集会プログラム・予稿集(Web), 2021
      • 【パンデミック時代の感染症研究 病原体の病原性、多様性、生活環から新型コロナウイルスを取り巻く社会の動きまで】(第1章)病原体を理解するプラットフォーム ウイルスRNA合成装置の微細構造解析
        中野 雅博; 野田 岳志
        実験医学, Feb. 2021

      Presentations

      • NS1欠損インフルエンザウイルス感染により誘導される二本鎖RNAの合成とその細胞内局在
        中野 雅博; 宮本 翔; 梶川 純一; 村本 裕紀子; 野田 岳志
        9th Negative Strand Virus-Japan Symposium, Jan. 2020
      • Identification of amino acid residues of influenza virus NS1 important for masking of double-stranded viral RNAs
        Masahiro Nakano; Sho Miyamoto; Junichi Kajikawa; Yukiko Muramoto; Takeshi Noda
        第67回 日本ウイルス学会学術集会, Oct. 2019
      • Ultrastructure of the influenza virus ribonucleoprotein complexes producing viral RNAs
        Masahiro Nakano
        17th NSV 2018, Jun. 2018
      • AFM analysis of dsRNA binding mechanism of influenza A virus NS1
        Masahiro Nakano
        7th Negative Strand Virus-Japan Symposium, Jan. 2018
      • Ultrastructural analysis of RNA synthesized by influenza virus vRNP
        Masahiro Nakano
        RNAフロンティアミーティング2017, Nov. 2017
      • The mechanism of genome transcription and replication of influenza virus analyzed by high-speed atomic force microscopy
        Masahiro Nakano
        6th Negative Strand Virus-Japan Symposium, Jan. 2017
      • Ultrastructural analysis of the influenza virus vRNP during transcription
        Masahiro Nakano
        5th Negative Strand Virus-Japan Symposium, Jan. 2016
      • Analysis of influenza virus transcription using high-speed atomic force microscopy
        Masahiro Nakano
        第29回 インフルエンザ研究者交流の会シンポジウム, May 2015

      External funds: Kakenhi

      • Masking of double-stranded RNA by the influenza A virus NS1 protein
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49060:Virology-related
        Kyoto University
        Masahiro Nakano
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        インフルエンザウイルス;自然免疫;二本鎖RNA;マスキング;高速原子間力顕微鏡;免疫蛍光染色;リボヌクレオタンパク質;自然免疫応答;リボヌクレオタンパク質複合体;原子間力顕微鏡
      • Toward the live imaging analysis of functional influenza virus RNPs
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Shindo Keiko
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        インフルエンザウイルス;転写;複製;RNP;リコンビナントRNP
      • Ultrastructural analysis of the virus ribonucleoprotein complexes by high-speed atomic force microsccopy
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Masahiro Nakano
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        インフルエンザウイルス;転写;複製;原子間力顕微鏡;RNAウイルス;高速原子間力顕微鏡;ライブイメージング
      • インフルエンザウイルスが産生する二本鎖RNAとその自然免疫誘導に関する研究
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49060:Virology-related
        Kyoto University
        中野 雅博
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        インフルエンザウイルス;二本鎖RNA;自然免疫;高速原子間力顕微鏡
      list
        Last Updated :2023/05/27

        Administration

        Faculty management (title, position)

        • From 01 Apr. 2018
          共同利用機器等委員会
        • From 01 Oct. 2016
          化学物質管理委員会 委員
        • From 01 Apr. 2016, To 31 Mar. 2017
          共同利用機器等委員会
        • From 01 Apr. 2016, To 31 Mar. 2017
          化学物質管理委員会 委員
        • From 01 Oct. 2016, To Mar. 2018
          (旧ウイルス研)共同利用機器等委員会 委員

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