Basic Information

Faculty

• 医学部

Academic Degree

• 修士（教育学）(奈良教育大学)
• 博士（医科学）(京都大学)

Research History

• Fukuoka University Faculty of Medicine, School of Medicine
• Kyoto University

Language of Instruction

• Japanese

ID,URL

• J-Global ID

  201401042110989752

researchmap URL

• https://researchmap.jp/7000009710

Research

Research Areas

• Other, Other

Papers

• Deletion of 2 amino acids in IHH in a Japanese family with brachydactyly type A1

  Nozomu Ozaki; Hiroko Okuda; Hatasu Kobayashi; Kouji H. Harada; Sumiko Inoue; Shohab Youssefian; Akio Koizumi

  BMC Medical Genomics, Dec. 2021

  
• E44Q mutation in NaV1.7 in a patient with infantile paroxysmal knee pain: Electrophysiological analysis of voltage-dependent sodium current

  Kiichi Takahashi; Takayoshi Ohba; Yosuke Okamoto; Atsuko Noguchi; Hiroko Okuda; Hatasu Kobayashi; Kouji H. Harada; Akio Koizumi; Kyoichi Ono; Tsutomu Takahashi

  Heliyon, Jun. 2021

  
• Mechanical allodynia triggered by cold exposure in mice with the Scn11a p.R222S mutation: a novel model of drug therapy for neuropathic pain related to NaV1.9.

  Yosuke Matsubara; Hiroko Okuda; Kouji H Harada; Shohab Youssefian; Akio Koizumi

  Naunyn-Schmiedeberg's archives of pharmacology, 24 Sep. 2020

  
• RNF213調節不全は両側総頸動脈狭窄マウスモデルの脳低灌流を悪化させる

  小林 果; 森本 貴昭; 原田 浩二; 奥田 裕子; Youssefian Shohab; 及川 伸二; 村田 真理子; 小泉 昭夫

  日本衛生学雑誌, Mar. 2020

  
• 小児四肢疼痛発作症のモデルマウスを用いたNav1.9変異チャネルの機能解析

  奥田 裕子; 加畑 理咲子; 小林 果; 人見 敏明; 原田 浩二; 小泉 昭夫

  日本衛生学雑誌, Mar. 2020

  
• Rnf213遺伝子改変マウスにおける免疫細胞・血清サイトカインの系統的解析

  小林 果; 西村 泰光; 奥田 裕子; 原田 浩二; 加畑 理咲子; 武田 美都里; 崔 廷米; Youssefian Shohab; 大槻 剛巳; 小泉 昭夫

  日本衛生学雑誌, Feb. 2019

  
• 小児四肢疼痛発作症の新規変異における電気生理学的特徴

  奥田 裕子; 加畑 理咲子; 小林 果; 人見 敏明; 原田 浩二; 小泉 昭夫

  日本衛生学雑誌, Feb. 2019

  
• 新たに診断された小児四肢疼痛発作症の1家系

  矢野 直子; 吉田 健司; 林 貴大; 高折 徹; 舞鶴 賀奈子; 横山 淳史; 奥田 裕子; 原田 浩二; 小泉 昭夫; 滝田 順子

  日本小児科学会雑誌, Feb. 2019

  
• Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice.

  Kobayashi H; Kabata R; Kinoshita H; Morimoto T; Ono K; Takeda M; Choi J; Okuda H; Liu W; Harada KH; Kimura T; Youssefian S; Koizumi A

  Pulmonary circulation, Jul. 2018, Peer-reviewed

  
• 福島第一原発事故による避難地域住民の耐糖能は4年後においても影響を受けている

  江藤 孝史; 奥田 裕子; 原田 浩二; 猪狩 恵子; 石塚 尋朗; 小泉 昭夫

  糖尿病, Jun. 2018

  
• 福島第一原発事故による避難地域住民の耐糖能は4年後においても影響を受けている

  江藤 孝史; 奥田 裕子; 原田 浩二; 猪狩 恵子; 石塚 尋朗; 小泉 昭夫

  日本衛生学雑誌, Mar. 2018

  
• Dysregulation of RNF213 promotes cerebral hypoperfusion.

  Takaaki Morimoto; Jun-Ichiro Enmi; Yorito Hattori; Satoshi Iguchi; Satoshi Saito; Kouji H Harada; Hiroko Okuda; Yohei Mineharu; Yasushi Takagi; Shohab Youssefian; Hidehiro Iida; Susumu Miyamoto; Masafumi Ihara; Hatasu Kobayashi; Akio Koizumi

  Scientific reports, 26 Feb. 2018, Peer-reviewed

  
• β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice

  Jungmi Choi; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Midori Takeda; Hiroyuki Fujimoto; Shunsuke Yamane; Daisuke Tanaka; Shohab Youssefian; Nobuya Inagaki; Akio Koizumi

  PLoS ONE, 01 Jan. 2018, Peer-reviewed

  
• Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families

  Hiroko Okuda; Atsuko Noguchi; Hatasu Kobayashi; Daiki Kondo; Kouji H. Harada; Shohab Youssefian; Hirotomo Shioi; Risako Kabata; Yuki Domon; Kazufumi Kubota; Yutaka Kitano; Yasunori Takayama; Toshiaki Hitomi; Kousaku Ohno; Yoshiaki Saito; Takeshi Asano; Makoto Tominaga; Tsutomu Takahashi; Akio Koizumi

  PLOS ONE, May 2016, Peer-reviewed

  
• Direct Interaction between the Voltage Sensors Produces Cooperative Sustained Deactivation in Voltage-gated H+ Channel Dimers

  Hiroko Okuda; Yasushige Yonezawa; Yu Takano; Yasushi Okamura; Yuichiro Fujiwara

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2016, Peer-reviewed

  
• Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics

  Kouji H. Harada; Keiko Tanaka; Hiroko Sakamoto; Mie Imanaka; Tamon Niisoe; Toshiaki Hitomi; Hatasu Kobayashi; Hiroko Okuda; Sumiko Inoue; Koichi Kusakawa; Masayo Oshima; Kiyohiko Watanabe; Makoto Yasojima; Takumi Takasuga; Akio Koizumi

  PLOS ONE, Jan. 2016, Peer-reviewed

  
• Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo

  Hatasu Kobayashi; Yoshiko Matsuda; Toshiaki Hitomi; Hiroko Okuda; Hirotomo Shioi; Tetsuya Matsuda; Hirohiko Imai; Masakatsu Sone; Daisuke Taura; Kouji H. Harada; Toshiyuki Habu; Yasushi Takagi; Susumu Miyamoto; Akio Koizumi

  JOURNAL OF THE AMERICAN HEART ASSOCIATION, Jul. 2015, Peer-reviewed

  
• Genetic Study of Intracranial Aneurysms

  Junxia Yan; Toshiaki Hitomi; Katsunobu Takenaka; Masayasu Kato; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Akio Koizumi

  STROKE, Mar. 2015, Peer-reviewed

  
• An Integrative Study of the Genetic, Social and Environmental Determinants of Chronic Kidney Disease Characterized by Tubulointerstitial Damages in the North Central Region of Sri Lanka

  Shanika Nanayakkara; Senevirathna Stmld; Tilak Abeysekera; Rohana Chandrajith; Neelakanthi Ratnatunga; Gunarathne Edl; Junxia Yan; Toshiaki Hitomi; Eri Muso; Toshiyuki Komiya; Kouji H. Harada; Wanyang Liu; Hatasu Kobayashi; Hiroko Okuda; Flideyuki Sawatari; Fumihiko Matsuda; Ryo Yamada; Takao Watanabe; Hideki Miyataka; Seiichiro Himeno; Akio Koizumi

  JOURNAL OF OCCUPATIONAL HEALTH, Jan. 2014, Peer-reviewed

  
• The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

  Toshiaki Hitomi; Toshiyuki Habu; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Kenji Osafune; Daisuke Taura; Masakatsu Sone; Isao Asaka; Tomonaga Ameku; Akira Watanabe; Tomoko Kasahara; Tomomi Sudo; Fumihiko Shiota; Hirokuni Hashikata; Yasushi Takagi; Daisuke Morito; Susumu Miyamoto; Kazuwa Nakao; Akio Koizumi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2013, Peer-reviewed

  
• Protein S K196E mutation, a genetic risk factor for venous thromboembolism, is limited to Japanese

  Wanyang Liu; Tong Yin; Hiroko Okuda; Kouji H. Harada; Yang Li; Bin Xu; Jie Yang; Hongjuan Wang; Xinping Fan; Akio Koizumi; Toshiyuki Miyata

  Thrombosis Research, Aug. 2013, Peer-reviewed

  
• Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G > A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients

  Toshiaki Hitomi; Toshiyuki Habu; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Kenji Osafune; Daisuke Taura; Masakatsu Sone; Isao Asaka; Tomonaga Ameku; Akira Watanabe; Tomoko Kasahara; Tomomi Sudo; Fumihiko Shiota; Hirokuni Hashikata; Yasushi Takagi; Daisuke Morito; Susumu Miyamoto; Kazuwa Nakao; Akio Koizumi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2013, Peer-reviewed

  
• Combined linkage analysis and exome sequencing identifies novel genes for familial goiter

  Junxia Yan; Tsutomu Takahashi; Toshihiro Ohura; Hiroyuki Adachi; Ikuko Takahashi; Eishin Ogawa; Hiroko Okuda; Hatasu Kobayashi; Toshiaki Hitomi; Wanyang Liu; Kouji H. Harada; Akio Koizumi

  JOURNAL OF HUMAN GENETICS, Jun. 2013, Peer-reviewed

  
• P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure

  Akio Koizumi; Hatasu Kobayashi; Wanyang Liu; Yukiko Fujii; S. T. M. L. D. Senevirathna; Shanika Nanayakkara; Hiroko Okuda; Toshiaki Hitomi; Kouji H. Harada; Katsunobu Takenaka; Takao Watanabe; Shinichiro Shimbo

  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, Mar. 2013, Peer-reviewed

  
• Ablation of Rnf213 retards progression of diabetes in the Akita mouse

  Hatasu Kobayashi; Satoru Yamazaki; Seiji Takashima; Wanyang Liu; Hiroko Okuda; Junxia Yan; Yukiko Fujii; Toshiaki Hitomi; Kouji H. Harada; Toshiyuki Habu; Akio Koizumi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2013, Peer-reviewed

  
• The Cooperation of Sustained and Phasic Inhibitions Increases the Contrast of ITD-Tuning in Low-Frequency Neurons of the Chick Nucleus Laminaris

  Rei Yamada; Hiroko Okuda; Hiroshi Kuba; Eri Nishino; Takahiro M. Ishii; Harunori Ohmori

  JOURNAL OF NEUROSCIENCE, Feb. 2013, Peer-reviewed

  
• Activation of metabotropic glutamate receptors improves the accuracy of coincidence detection by presynaptic mechanisms in the nucleus laminaris of the chick

  Hiroko Okuda; Rei Yamada; Hiroshi Kuba; Harunori Ohmori

  JOURNAL OF PHYSIOLOGY-LONDON, Jan. 2013, Peer-reviewed

  
• Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes SCA36, a Type of Spinocerebellar Ataxia Accompanied by Motor Neuron Involvement

  Hatasu Kobayashi; Koji Abe; Tohru Matsuura; Yoshio Ikeda; Toshiaki Hitomi; Yuji Akechi; Toshiyuki Habu; Wanyang Liu; Hiroko Okuda; Akio Koizumi

  AMERICAN JOURNAL OF HUMAN GENETICS, Jul. 2011, Peer-reviewed

  
• Blockade of angiotensin II receptors reduces the expression of receptors for advanced glycation end products in human endothelial cells

  Masashi Fujita; Hiroko Okuda; Osamu Tsukamoto; Yoshihiro Asano; Yulin Liao; Akio Hirata; Jiyoong Kim; Takeshi Miyatsuka; Seiji Takashima; Tetsuo Minamino; Hitonobu Tomoike; Masafumi Kitakaze

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Oct. 2006, Peer-reviewed

  
• Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts

  M Fujita; T Minamino; H Asanuma; S Sanada; A Hirata; M Wakeno; M Myoishi; H Okuda; A Ogai; K Okada; O Tsukamoto; H Koyama; M Hori; M Kitakaze

  HYPERTENSION, Jul. 2005, Peer-reviewed

  
• Opening of Ca2+-activated K+ channels is involved in ischemic preconditioning in canine hearts

  Y Shintani; K Node; H Asanuma; S Sanada; S Takashima; Y Asano; YL Liao; M Fujita; A Hirata; Y Shinozaki; T Fukushima; Y Nagamachi; H Okuda; J Kim; H Tomoike; M Hori; M Kitakaze

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Dec. 2004, Peer-reviewed

  
• Optimal windows of statin use for immediate infarct limitation - 5 '-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase

  S Sanada; H Asanuma; T Minamino; K Node; S Takashima; H Okuda; Y Shinozaki; A Ogai; M Fujita; A Hirata; JY Kim; Y Asano; H Mori; H Tomoike; S Kitamura; M Hori; M Kitakaze

  CIRCULATION, Oct. 2004, Peer-reviewed

  
• Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C

  S Sanada; H Asanuma; O Tsukamoto; T Minamino; K Node; S Takashima; T Fukushima; A Ogai; Y Shinozaki; M Fujita; A Hirata; H Okuda; H Shimokawa; H Tomoike; M Hori; M Kitakaze

  CIRCULATION, Jul. 2004, Peer-reviewed

  

Misc.

• Exome sequencing for intracranial aneurysms families in Japan

  K. Takenaka; M. Kato; Y. Nonaka; J. Yan; T. Hitomi; H. Kobayashi; H. Okuda; K. Harada; A. Koizumi

  CEREBROVASCULAR DISEASES, 2015

  
• SIGNIFICANCE OF RNF213 IN TUMORGENICITY OF MEDULLOBLASTOMA

  Yohei Mineharu; Yuki Oichi; Takahiko Kamata; Yasuzumi Matsui; Takaaki Morimoto; Masahiro Tanji; Hatasu Kobayashi; Hiroko Okuda; Kouji H. Harada; Akio Koizumi; Yoshiki Arakawa; Susumu Miyamoto

  NEURO-ONCOLOGY, Dec. 2020

  
• 小児四肢疼痛発作症の新規変異を持つマウスモデルの電気生理学的解析

  奥田裕子; 加畑理咲子; 小林果; 人見敏明; 原田浩二; 小泉昭夫

  第88回日本衛生学会学術総会 2018年3月 東京, Mar. 2018

  
• 周期性四肢関節症の疼痛マウスモデルの電気生理学的解析

  奥田裕子; 小林果; 原田浩二; 小泉昭夫

  第86回日本衛生学会学術総会 2016年5月 旭川, May 2016, Peer-reviewed

  
• Akitaマウスにおける耐糖能改善に関わる分子機構の解析

  奥田裕子; 小林果; 人見敏明; 小泉昭夫

  第85回日本衛生学会学術総会 2015年3月 和歌山, Mar. 2015, Peer-reviewed

  

External funds: Kakenhi

• Elucidation of infantile episodic limb pain mechanism induced by cold exposure

  Grant-in-Aid for Scientific Research (C)

  Basic Section 58020:Hygiene and public health-related: including laboratory approach

  Kyoto University

  奥田 裕子

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  小児四肢疼痛発作症;SCN11A;SCN10A;モデルマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K10394/
• Investigation of mechanisms of pain evoked by meteorological environment

  Grant-in-Aid for Challenging Research (Pioneering)

  Kyoto University

  原田 浩二

  From 30 Jun. 2017, To 31 Mar. 2021, Granted

  疼痛;温度;気象環境;細胞内輸送;ナトリウムチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20308/
• Role of mitochondrial Ca2+ transporter in vascular function and vascular diseases

  Grant-in-Aid for Scientific Research (C)

  Tokushima Bunri University;Fukuoka University

  Satomi Kita

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  ミトコンドリア;Ca輸送体;イオン輸送体;血管病;薬理学;輸送体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08565/
• Functional analysis of novel mutations of SCN11A for future drug of familial episodic pain

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hiroko Okuda

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  小児四肢疼痛発作症;難病;ＳＣＮ11Ａ;チャネロパチー;SCN11A;家族性四肢疼痛;ナトリウムチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08772/

External funds: others

• 新規周期性四肢疼痛症の加齢による寛解の分子機構解明と創薬への応用

  日本医療研究開発機構研究費　慢性の痛み解明研究事業

  From 01 Apr. 2015, To 31 Mar. 2018

  小林　果

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  Environmental exposures and their risk assessments

  H159, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Toxicological Sciences

  H162, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  On the Bench Training Course

  H032, Fall, Graduate School of Medicine, 2
• From Apr. 2018, To Mar. 2019

  Introduction to Toxicology

  Spring, 医学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Toxicology

  Spring, 医学研究科