Researchers Information System

日本語に切り替えるswitch to english

Komorizono, Ryo

Institute for Life and Medical Sciences (LiMe) Program-Specific Assistant Professor

Komorizono, Ryo
list
    Last Updated :2024/04/22

    Basic Information

    Academic Degree

    • 23 Mar. 2022
      京都大学博士(生命科学)
    • 23 Mar. 2017
      京都大学修士(生命科学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院生命科学研究科博士後期課程高次生命科学専攻, 修了
    • 京都大学, 大学院生命科学研究科修士課程高次生命科学専攻, 修了
    • 京都大学, 大学院生命科学研究科博士後期課程高次生命科学専攻, 研究指導認定退学

    Academic Resume (Undergraduate School/Majors)

    • 鹿児島大学, 農学部生物資源化学科, 卒業

    Research History

    • From Apr. 2022, To Present
      Kyoto University, Institute for Life and Medical Sciences, Program-Specific Assistant Professor
    • From Apr. 2020, To Mar. 2022
      Kyoto University, Institute for frontier life and medical sciences, Researcher
    • From Apr. 2017, To Mar. 2020
      Japan Society for the Promotion of Science, 特別研究員DC1

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2024/04/22

      Research

      Research Interests

      • 細胞治療
      • Viral vector
      • Gene therapy
      • Viral evolution
      • Virology

      Research Areas

      • Life sciences, Molecular biology
      • Life sciences, Pharmaceuticals - chemistry and drug development
      • Life sciences, Virology

      Papers

      • Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution
        Junya Sunagawa; Hyeongki Park; Kwang Su Kim; Ryo Komorizono; Sooyoun Choi; Lucia Ramirez Torres; Joohyeon Woo; Yong Dam Jeong; William S. Hart; Robin N. Thompson; Kazuyuki Aihara; Shingo Iwami; Ryo Yamaguchi
        Nature Communications, 21 Nov. 2023, Peer-reviewed
      • Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation
        Ryo Komorizono; Kan Fujino; Susanne Kessler; Solveig Runge; Takehiro Kanda; Masayuki Horie; Akiko Makino; Dennis Rubbenstroth; Keizo Tomonaga
        Journal of Virology, Aug. 2023, Peer-reviewed, Lead author
      • Genome-scale CRISPR‒Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection
        Madoka Sakai; Yoshie Masuda; Yusuke Tarumoto; Naoyuki Aihara; Yugo Tsunoda; Michiko Iwata; Yumiko Kamiya; Ryo Komorizono; Takeshi Noda; Kosuke Yusa; Keizo Tomonaga; Akiko Makino
        07 Mar. 2023
      • Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection
        Junya Sunagawa; Ryo Komorizono; Hyeongki Park; William S. Hart; Robin N. Thompson; Akiko Makino; Keizo Tomonaga; Shingo Iwami; Ryo Yamaguchi
        PLOS Computational Biology, 30 May 2023, Peer-reviewed, Lead author
      • Ban on wild bird importation accelerated the spread of global viral outbreaks in parrots
        Ryo Komorizono; Naoyuki Aihara; Chinatsu Fujiwara; Junichi Kamiie; Keizo Tomonaga; Akiko Makino
        biorxiv, Jun. 2022, Lead author
      • Stability of Borna disease virus ‐based episomal vector under physical and chemical stimulation
        Mako Yanai; Madoka Sakai; Ryo Komorizono; Akiko Makino; Keizo Tomonaga
        Microbiology and Immunology, 07 Oct. 2021, Peer-reviewed
      • Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus
        Ryo Komorizono; Yukiko Sassa; Masayuki Horie; Akiko Makino; Keizo Tomonaga
        Viruses, 11 Nov. 2020, Peer-reviewed, Lead author
      • In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector
        Yumiko Komatsu; Chiaki Tanaka; Ryo Komorizono; Keizo Tomonaga
        Scientific Reports, 03 Apr. 2020, Peer-reviewed
      • ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus
        Mako Yanai; Shohei Kojima; Madoka Sakai; Ryo Komorizono; Keizo Tomonaga; Akiko Makino
        Journal of Virology, Feb. 2020, Peer-reviewed
      • Optimal Expression of the Envelope Glycoprotein of Orthobornaviruses Determines the Production of Mature Virus Particles
        Madoka Sakai; Yoko Fujita; Ryo Komorizono; Takehiro Kanda; Yumiko Komatsu; Takeshi Noda; Keizo Tomonaga; Akiko Makino
        Journal of Virology, 10 Feb. 2021, Peer-reviewed
      • Development of a reverse transcription-loop-mediated isothermal amplification assay for the detection of parrot bornavirus 4
        Ryo Komorizono; Keizo Tomonaga; Akiko Makino
        Journal of Virological Methods, Jan. 2020, Peer-reviewed, Lead author
      • Sequence determination of a new parrot bornavirus-5 strain in Japan: implications of clade-specific sequence diversity in the regions interacting with host factors
        Ryo Komorizono; Akiko Makino; Masayuki Horie; Tomoyuki Honda; Keizo Tomonaga
        Microbiology and Immunology, Jun. 2016, Peer-reviewed, Lead author

      Misc.

      • A novel RNA virus-based episomal vector system for long-term stem cell modification
        A. Makino; R. Komorizono; S. J. Holditch; B. Lu; T. Honda; Y. Ikeda; K. Tomonaga
        HUMAN GENE THERAPY, Oct. 2015
      • Improvement of the production of Borna disease virus vector
        A. Makino; R. Komorizono; M. Sakai; K. Tomonaga
        HUMAN GENE THERAPY, Nov. 2016

      Presentations

      • Self-amplifying RNA viral vector for gene therapy and vaccine platform development
        小森園 亮; 京都大学KUMBL
        BIO International Convention 2024
      • 多発性硬化症治療を目指したmiRNA分泌型遺伝子細胞治療薬の開発
        Ryo Komorizono; Keizo Tomonaga
        令和5年度AMED再生・細胞医療・遺伝子治療プロジェクト研究交流会, 01 Nov. 2023
      • Application of self-amplifying viral vector "REVec"
        小森園亮; 京都大学KUMBL
        BioJapan2023
      • Excel-REGENS: The ex vivo gene cell therapy using REVec-based genetically engineered stem cells.
        Ryo Komorizono; Shima Yoshizumi; Keizo Tomonaga
        The 70th annual meeting of the Japanese Society for Virology, 27 Sep. 2023
      • Ex vivo gene-cell therapy using bornavirus vector
        Ryo Komorizono
        The 29th Annual Meeting of Japan Society of Gene and Cell Therapy, 12 Sep. 2023, Invited
      • RNA Virus Based Episomal Vector for Highly Efficient Genetic Engineering of Human Mesenchymal Stromal Cells
        Ryo Komorizono; Shima Yoshizumi; Miya Kawanaka; Keizo Tomonaga
        American Society of Gene & Cell Therapy The 26th Annual Meeting, May 2023
      • Development of gene therapeutics using novel viral vectors
        Ryo Komorizono
        BRAVE GATE Meetup(BNV), 18 Feb. 2023
      • Product of a human endogenous bornavirus-like element suppresses RNA interference in mammalian cells
        Ryo Komorizono; Miya Kawanaka; Shima Yoshizumi; Keizo Tomonaga
        The 69th annual meeting of the Japanese society for Virology, Nov. 2022
      • Intranuclear viral RdRp of Borna disease virus 1 interferes with host RNA maturation and metabolism.
        Miina Kaneko; Ryo Komorizono; Akiko Makino; Keizo Tomonaga
        The 20th Awaji International Forum on Infection and Immunity, 08 Sep. 2022
      • Development of an RNA virus-based episomal vector with artificial aptazyme for switching gene expression off
        Ryo Komorizono; Chiaki Tanaka; Shima Yoshizumi; Keizo Tomonaga
        The 23rd annual meeting of the RNA society of Japan
      • Curing Disease with a Minor Virus
        Ryo Komorizono
        第12回 Entrepreneur Candidate Club, Jan. 2022, Invited
      • Selection and characterization of persistent infectious variants of SARS-CoV-2
        Ryo Komorizono; Junna Kawasaki; Akiko Makino; Keizo Tomonaga
        The 68th annual meeting of the Japanese society for Virology, Nov. 2021
      • Development of geme therapy agents using novel viral vevtor "REVec"
        Ryo Komorizono
        京都・関西発ライフサイエンスベンチャーMEETUP, Mar. 2021, Invited
      • Development of geme therapy agents using novel viral vevtor "REVec"
        Ryo Komorizono
        RINK Festival 2021, Feb. 2021, Invited
      • Establishment of a plasmid-based reverse genetics system for parrot bornavirus 4
        Ryo Komorizono; Kan Fujino; Masayuki Horie; Susanne Kessler; Solveig Runge; Takehiro Kanda; Akiko Makino; Dennis Rubbenstroth; Keizo Tomonaga
        The 67th annual meeting of the Japanese society for Virology, Oct. 2019
      • Survival of the fittest strategy achieves genetic homeostasis of borna disease virus.
        The 2nd International Symposium on Virus Infection and Host Response, Mar. 2019
      • Intra-host diversity of borna disease virus
        The 66th annual meeting of the Japanese society for Virology, Oct. 2018
      • An outbreak of avian bornaviruses in bleeding facility in Japan
        The 161st meeting of the Japanese society of Veterinary Science, Sep. 2018
      • Nuclear transport is the driving force of adaptive evolution of bornaviruses
        The 7th Negative Strand Virus-Japan, Jan. 2018
      • Genomic analysis of bornaviruses implies the clade 2 avian bornaviruses possess mammalian-adapted gene composition
        The 65th annual meeting of the Japanese society for Virology, Oct. 2017
      • Molecular mechanisms and evolutionary features of the host range determination of bornaviruses
        Joint Conference of the Societies for Environmental Microbiology, Aug. 2017
      • Host range of bornaviruses implies an evolutionary arm race between persistently infected RNA virus and host
        Keystone Symposia Conference : Viral immunity mechanisms and consequences, Feb. 2017
      • The cell entry step is not a major determinant of host range of avian bornaviruses
        The 64th annual meeting of the Japanese society for Virology, Oct. 2016
      • Host range restriction and zoonotic potential of emerging avian bornaviruses
        The 15th Awaji International Forum on Infection and Immunity, Sep. 2016
      • Sequence analysis of a novel parrot bornavirus 5
        The 63th annual meeting of the Japanese society for Virology, Oct. 2015

      Industrial Property Rights

      • 特願2024- 45885, ボルナウイルスベクターを利用した細胞の遺伝子改変と当該細胞を用いた細胞治療薬
      • PCT/JP2022/032784, Pharmaceutical composition utilizing bornavirus vector
      • 特願2021-143184, ボルナウイルスベクターを利用した医薬組成物

      Awards

      • 13 Sep. 2018
        第161回日本獣医学会微生物分科会若手奨励賞
      • 17 Jan. 2018
        ベスト・オーラル・プレゼンテーション賞(Negative Strand Virus-Japan)

      External funds: Kakenhi

      • Quality and evolutionary control of RNA virus genome via nonsense mediated mRNA decay
        Grant-in-Aid for Research Activity Start-up
        0803:Pathology, infection/immunology, and related fields
        Kyoto University
        小森園 亮
        From 31 Aug. 2022, To 31 Mar. 2024, Granted
        RNAウイルス;ウイルス進化;RNA分解

      External funds: others

      • RNAウイルス型エピソーマルベクターによる幹細胞への遺伝子導入技術を用いた創薬ならびに研究支援事業
        京都大学, インキュベーションプログラム
        From 01 Apr. 2020, To 31 Mar. 2022
        小森園 亮
        朝長 啓造
        代表
      • ウイルスRNAポリメラーゼが織りなす遺伝子ネットワーク解析
        一般財団法人藤原記念財団, 令和4年度藤原記念財団奨励金
        From 01 Jul. 2022, To 31 Mar. 2023
        小森園 亮
        代表

      ページ上部へ戻る