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Takakura, Yoshinobu

Graduate School of Pharmaceutical Sciences, Division of Biomedical Sciences Professor

Takakura, Yoshinobu
list
    Last Updated :2022/07/01

    Basic Information

    Faculty

    • 薬学部

    Professional Memberships

    • American Association of Gene THerapy
    • 日本医療薬学会
    • Controlled Reliase Society
    • American Association of Pharmaceutical Scientists
    • 日本癌学会
    • 日本DDS学会
    • 日本薬物動態学会
    • 日本薬剤学会
    • 日本薬学会
    • American Association of Gene Therapy

    Academic Degree

    • 薬学修士(京都大学)
    • 薬学博士(京都大学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院薬学研究科修士課程薬学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 薬学部薬学科, 卒業

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2022/07/01

      Research

      Research Interests

      • ドラッグデリバリーシステム
      • 生物薬剤学
      • Drug Delivery System
      • Biopharmaceutics

      Research Areas

      • Life sciences, Pharmaceuticals - chemistry and drug development
      • Life sciences, Pharmacology
      • Life sciences, Pharmaceuticals - health and biochemistry

      Papers

      • Enhanced Immunostimulatory Activity of Covalent DNA Dendrons
        Yusuke Kawamoto; Wen Liu; Ji Hye Yum; Soyoung Park; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura
        ChemBioChem, 08 Dec. 2021
      • Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply
        Yuya Mizukami; Yuki Takahashi; Kazunori Shimizu; Satoshi Konishi; Yoshinobu Takakura; Makiya Nishikawa
        Biological and Pharmaceutical Bulletin, 01 Oct. 2021
      • The effect of the molecular weight of glycosylated proteins on their targeting efficiency to the liver.
        Nishikawa Makiya; Hirabayashi Hideki; Takakura Yoshinobu; Hashida Mitsuru
        Drug Delivery System, 1994
      • Development of evaluation method for drug disposition in tumor using tissue-isolated tumor perfusion system.
        Imoto Hirofumi; Ohkouchi Kazuhiro; Takakura Yoshinobu; Hashida Mitsuru; Sezaki Hitoshi
        Drug Delivery System, 1990
      • Control of biopharmaceutical properties of uricase by conjugation with dextran derivatives.
        Takakura Yoshinobu; Fujita Takuya; Yasuda Yoshihisa; Hashida Mitsuru; Sezaki Hitoshi
        Drug Delivery System, 1989
      • Targeting for cancer using monoclonal antibody as a drug carrier.:Targeting for cancer using monoclonal antibody as a drug carrier
        Noguchi Akinori; Takahashi Toshio
        Drug Delivery System, 1989
      • Molecular structure of modificated DDS by using dextran as a carrier.
        高倉 喜信; 安田 芳久; 橋田 充; 瀬崎 仁
        Drug Delivery System, 1988
      • 動注療法における効果増強を目的としたマイトマイシンCプロドラッグの開発
        橋田 充; 高倉 喜信; 瀬崎 仁
        Drug Delivery System, 1987
      • [MOURNING] In memory of Dr.Shigeru Tsukagoshi
        Takakura Yoshinobu
        Drug Delivery System, 2016
      • Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood.
        Akihiro Matsumoto; Yuki Takahashi; Kosuke Ogata; Shimpei Kitamura; Naoki Nakagawa; Aki Yamamoto; Yasushi Ishihama; Yoshinobu Takakura
        iScience, 20 Aug. 2021
      • Determining the role of surface glycans in the pharmacokinetics of small extracellular vesicles.
        Aki Yamamoto; Yukari Yasue; Yuki Takahashi; Yoshinobu Takakura
        Journal of pharmaceutical sciences, 03 Jun. 2021
      • Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
        Keisuke Umemura; Shozo Ohtsuki; Makoto Nagaoka; Kosuke Kusamori; Takao Inoue; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Nanomedicine : nanotechnology, biology, and medicine, 24 Mar. 2021
      • Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide.
        Yuki Araie; Shozo Ohtsuki; Soyoung Park; Makoto Nagaoka; Keisuke Umemura; Hiroshi Sugiyama; Kosuke Kusamori; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Bioorganic & medicinal chemistry, 01 Jan. 2021
      • Intercellular delivery of NF-κB inhibitor peptide utilizing small extracellular vesicles for the application of anti-inflammatory therapy.
        Misako Takenaka; Yuki Takahashi; Yoshinobu Takakura
        Journal of controlled release : official journal of the Controlled Release Society, 10 Dec. 2020
      • Antitumor immunity by small extracellular vesicles collected from activated dendritic cells through effective induction of cellular and humoral immune responses.
        Akihiro Matsumoto; Maho Asuka; Yuki Takahashi; Yoshinobu Takakura
        Biomaterials, Sep. 2020, Peer-reviewed
      • DNA density-dependent uptake of DNA origami-based two-or three-dimensional nanostructures by immune cells.
        Tatsuoki Maezawa; Shozo Ohtsuki; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Nanoscale, 16 Jul. 2020, Peer-reviewed
      • Development of CD40L-modified tumor small extracellular vesicles for effective induction of antitumor immune response.
        Wen Liu; Yuki Takahashi; Masaki Morishita; Makiya Nishikawa; Yoshinobu Takakura
        Nanomedicine (London, England), 15 Jul. 2020, Peer-reviewed
      • Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice.
        Yuto Nakamura; Shunbun Kita; Yoshimitsu Tanaka; Shiro Fukuda; Yoshinari Obata; Tomonori Okita; Hiroyuki Nishida; Yuki Takahashi; Yusuke Kawachi; Yuri Tsugawa-Shimizu; Yuya Fujishima; Hitoshi Nishizawa; Yoshinobu Takakura; Shigeru Miyagawa; Yoshiki Sawa; Norikazu Maeda; Iichiro Shimomura
        Molecular therapy : the journal of the American Society of Gene Therapy, 08 Jul. 2020, Peer-reviewed
      • Construction of Monomeric and Dimeric G-Quadruplex-Structured Cytosine-Phosphate-Guanine Oligodeoxynucleotides for Enhanced Uptake and Activation in Toll-Like Receptor 9-Positive Macrophages.
        Wenqing Liao; Mengmeng Tan; Kosuke Kusamori; Yoshinobu Takakura; Makiya Nishikawa
        Nucleic acid therapeutics, 22 Jun. 2020, Peer-reviewed
      • Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation.
        Fusae Komura; Kana Okuzumi; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Molecules (Basel, Switzerland), 07 Feb. 2020, Peer-reviewed
      • Analysis of Tertiary Structural Features of Branched DNA Nanostructures with Partially Common Sequences Using Small-Angle X-ray Scattering
        Mengmeng Tan; Natsuki Takahashi; Shota Fujii; Kazuo Sakurai; Kosuke Kusamori; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        ACS Applied Bio Materials, 21 Jan. 2020, Peer-reviewed
      • Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical and Pharmacokinetic Challenges.
        Yoshinobu Takakura; Akihiro Matsumoto; Yuki Takahashi
        Biological & pharmaceutical bulletin, 2020, Peer-reviewed
      • Incorporation of gelatin microspheres into HepG2 human hepatocyte spheroids for functional improvement through improved oxygen supply to spheroid core
        Yuya Mizukami; Ai Moriya; Yuki Takahashi; Kazunori Shimizu; Satoshi Konishi; Yoshinobu Takakura; Makiya Nishikawa
        Biological and Pharmaceutical Bulletin, 2020, Peer-reviewed
      • Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA
        Wenqing Liao; Sakiko Akahira; Rintaro; Iwata Hara; Takeshi Wada; Kosuke Kusamori; Yoshinobu Takakura; Makiya Nishikawa
        Biological and Pharmaceutical Bulletin, 2020, Peer-reviewed
      • Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance.
        Matsumoto A; Takahashi Y; Chang HY; Wu YW; Yamamoto A; Ishihama Y; Takakura Y
        Journal of extracellular vesicles, 2020, Peer-reviewed
      • Development of DNA-anchored assembly of small extracellular vesicle for efficient antigen delivery to antigen presenting cells.
        Matsumoto A; Takahashi Y; Ariizumi R; Nishikawa M; Takakura Y
        Biomaterials, Dec. 2019, Peer-reviewed
      • Effects of Localization of Antigen Proteins in Antigen-Loaded Exosomes on Efficiency of Antigen Presentation.
        Arima Y; Liu W; Takahashi Y; Nishikawa M; Takakura Y
        Molecular pharmaceutics, Jun. 2019, Peer-reviewed
      • Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment
        Ippei Takashima; Kosuke Kusamori; Hayase Hakariya; Megumi Takashima; Thi Hue Vu; Yuya Mizukami; Naotaka Noda; Yukiya Takayama; Yousuke Katsuda; Shin-ichi Sato; Yoshinobu Takakura; Makiya Nishikawa; Motonari Uesugi
        ACS Chemical Biology, 19 Apr. 2019, Peer-reviewed
      • Erratum to 'Preservation of exosomes at room temperature using lyophilization' [International Journal of Pharmaceutics 553 (2018) 1-7].
        Chonlada Charoenviriyakul; Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        International journal of pharmaceutics, 25 Mar. 2019
      • Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake.
        S. Ohtsuki; Y. Shiba; T. Maezawa; K. Hidaka; H. Sugiyama; M. Endo; Y. Takahashi; Y. Takakura; M. Nishikawa
        Nanoscale, Mar. 2019, Peer-reviewed
      • Regulation of the Distribution of Cells in Mixed Spheroids by Altering Migration Direction.
        Mizukami Y; Takahashi Y; Shimizu K; Konishi S; Takakura Y; Nishikawa M
        Tissue engineering. Part A, Mar. 2019, Peer-reviewed
      • Development of a nanostructured RNA/DNA assembly as an adjuvant targeting Toll-like receptor 7/8.
        Komura F; Takahashi Y; Inoue T; Takakura Y; Nishikawa M
        NUCLEIC ACID THER, 2019, Peer-reviewed
      • Preservation of exosomes at room temperature using lyophilization.
        Charoenviriyakul C; Takahashi Y; Nishikawa M; Takakura Y
        International journal of pharmaceutics, Dec. 2018, Peer-reviewed
      • Combined encapsulation of a tumor antigen and immune cells using a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity.
        Umeki Y; Saito M; Kusamori K; Tsujimura M; Nishimura M; Takahashi Y; Takakura Y; Nishikawa M
        Journal of controlled release : official journal of the Controlled Release Society, Oct. 2018, Peer-reviewed
      • Development of orally-deliverable DNA hydrogel by microemulsification and chitosan coating
        Daiki Nomura; Masaaki Saito; Yosuke Takahashi; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        International Journal of Pharmaceutics, 25 Aug. 2018, Peer-reviewed
      • Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application
        Takuma Yamashita; Yuki Takahashi; Yoshinobu Takakura
        Biological and Pharmaceutical Bulletin, 01 Jun. 2018, Peer-reviewed
      • Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice
        Yosuke Takahashi; Yuki Araie; Daiki Nomura; Yuki Takahashi; Kohei Sano; Hideo Saji; Yoshinobu Takakura; Makiya Nishikawa
        Journal of Drug Targeting, 21 Apr. 2018, Peer-reviewed
      • Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles.
        Chonlada Charoenviriyakul; Yuki Takahashi; Masaki Morishita; Makiya Nishikawa; Yoshinobu Takakura
        Molecular pharmaceutics, 05 Mar. 2018, Peer-reviewed
      • Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins
        Atsushi Hamana; Yuki Takahashi; Akane Tanioka; Makiya Nishikawa; Yoshinobu Takakura
        International Journal of Pharmaceutics, 30 Jan. 2018, Peer-reviewed
      • Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation
        Yutaro Tanaka; Makiya Nishikawa; Yuya Mizukami; Kosuke Kusamori; Yuka Ogino; Shunsuke Nishimura; Kazunori Shimizu; Satoshi Konishi; Yuki Takahashi; Yoshinobu Takakura
        Journal of Controlled Release, 28 Jan. 2018, Peer-reviewed
      • Enhanced activity of immunosuppressive oligodeoxynucleotides by incorporating them into hexapod-like nanostructured DNA
        Yuki Araie; Yosuke Takahashi; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        Biological and Pharmaceutical Bulletin, 2018, Peer-reviewed
      • Screening of Exosome-Tropic RNA
        Takuma Yamashita; Haruka Shinotsuka; Yuki Takahashi; Kana Kato; Makiya Nishikawa; Yoshinobu Takakura
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 2017, Peer-reviewed
      • Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure
        Kohta Mohri; Kengo Nagata; Shozo Ohtsuki; Shiori Toyama; Mao Nonomura; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa; Shinji Sakuma
        PHARMACEUTICAL RESEARCH, Nov. 2017, Peer-reviewed
      • DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy
        Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Hirotaka Nakatsuji; Shozo Ohtsuki; Tatsuya Murakami; Hiroshi Imahori; Yuka Umeki; Tomoki Shiomi; Yoshinobu Takakura; Makiya Nishikawa
        BIOMATERIALS, Nov. 2017, Peer-reviewed
      • Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide
        Masaki Morishita; Yuki Takahashi; Makiya Nishikawa; Reiichi Ariizumi; Yoshinobu Takakura
        MOLECULAR PHARMACEUTICS, Nov. 2017, Peer-reviewed
      • Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus
        Atsushi Hamana; Yuki Takahashi; Takuro Uchida; Makiya Nishikawa; Michio Imamura; Kazuaki Chayama; Yoshinobu Takakura
        ANTIVIRAL RESEARCH, Oct. 2017, Peer-reviewed
      • Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene
        Shozo Ohtsuki; Yuki Takahashi; Takao Inoue; Yoshinobu Takakura; Makiya Nishikawa
        SCIENTIFIC REPORTS, Oct. 2017, Peer-reviewed
      • Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response
        Yuka Umeki; Masaaki Saito; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        ADVANCED HEALTHCARE MATERIALS, Oct. 2017, Peer-reviewed
      • Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells
        Akihiro Matsumoto; Yuki Takahashi; Makiya Nishikawa; Kohei Sano; Masaki Morishita; Chonlada Charoenviriyakul; Hideo Saji; Yoshinobu Takakura
        CANCER SCIENCE, Sep. 2017, Peer-reviewed
      • Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics
        Masaki Morishita; Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2017, Peer-reviewed
      • In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides Incorporated Into Polypod-Like DNA Nanostructures
        Yosuke Takahashi; Tatsuoki Maezawa; Yuki Araie; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2017, Peer-reviewed
      • Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells.
        Akihiro Matsumoto; Yuki Takahashi; Makiya Nishikawa; Kohei Sano; Masaki Morishita; Chonlada Charoenviriyakul; Hideo Saji; Yoshinobu Takakura
        Cancer science, Sep. 2017, Peer-reviewed
      • Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice
        Tomoko Nishikawa; Yutaro Tanaka; Kosuke Kusamori; Narumi Mizuno; Yuya Mizukami; Yuka Ogino; Kazunori Shimizu; Satoshi Konishi; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        BIOTECHNOLOGY JOURNAL, Aug. 2017, Peer-reviewed
      • Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector
        Atsushi Hamana; Yuki Takahashi; Akane Tanioka; Makiya Nishikawa; Yoshinobu Takakura
        MOLECULAR PHARMACEUTICS, Apr. 2017, Peer-reviewed
      • Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy
        Mitsuru Ando; Mai Fujimoto; Yuki Takahashi; Makiya Nishikawa; Atsushi Hamana; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Mar. 2017, Peer-reviewed
      • Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size
        Tomoko Nishikawa; Yutaro Tanaka; Makiya Nishikawa; Yuka Ogino; Kosuke Kusamori; Narumi Mizuno; Yuya Mizukami; Kazunori Shimizu; Satoshi Konishi; Yuki Takahashi; Yoshinobu Takakura
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2017, Peer-reviewed
      • In Vivo Tracking of Extracellular Vesicles in Mice Using Fusion Protein Comprising Lactadherin and Gaussia Luciferase.
        Takahashi Y; Nishikawa M; Takakura Y
        Methods in molecular biology (Clifton, N.J.), 2017, Peer-reviewed
      • Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages
        Akihiro Matsumoto; Yuki Takahashi; Makiya Nishikawa; Kohei Sano; Masaki Morishita; Chonlada Charoenviriyakul; Hideo Saji; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 2017, Peer-reviewed
      • Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics
        Chonlada Charoenviriyakul; Yuki Takahashi; Masaki Morishita; Akihiro Matsumoto; Makiya Nishikawa; Yoshinobu Takakura
        EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 2017, Peer-reviewed
      • Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan
        Yumiko Ishii-Mizuno; Yuka Umeki; Yoshinori Onuki; Hiroshi Watanabe; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jan. 2017, Peer-reviewed
      • Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA
        Masaki Morishita; Yuki Takahashi; Akihiro Matsumoto; Makiya Nishikawa; Yoshinobu Takakura
        BIOMATERIALS, Dec. 2016, Peer-reviewed
      • Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression System of Interferon-beta for Cancer Gene Therapy
        Atsushi Hamana; Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        HUMAN GENE THERAPY, Nov. 2016, Peer-reviewed
      • Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer
        Y. Yin; Y. Takahashi; A. Hamana; M. Nishikawa; Y. Takakura
        GENE THERAPY, Jul. 2016, Peer-reviewed
      • Depressive symptoms as a side effect of Interferon-alpha therapy induced by induction of indoleamine 2,3-dioxygenase 1
        Yuki Murakami; Takaaki Ishibashi; Eiichi Tomita; Yukio Imamura; Tomoyuki Tashiro; Kanitta Watcharanurak; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura; Satoko Mitani; Hidetsugu Fujigaki; Yoshiji Ohta; Hisako Kubo; Takayoshi Mamiya; Toshitaka Nabeshima; Hyoung-Chun Kim; Yasuko Yamamoto; Kuniaki Saito
        SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed
      • Polypod-Shaped DNAs: Small-Angle X-ray Scattering and Immunostimulatory Activity
        Yusuke Sanada; Tomoki Shiomi; Tadashi Okobira; Mengmeng Tan; Makiya Nishikawa; Isamu Akiba; Yoshinobu Takakura; Kazuo Sakurai
        LANGMUIR, Apr. 2016, Peer-reviewed
      • エキソソームのマクロファージによる取り込みにおけるホスファチジルセリンの関与
        松本 明宏; 高橋 有己; 佐野 紘平; 森下 将輝; Charoenviriyakul Chonlada; 西川 元也; 佐治 英郎; 高倉 喜信
        日本薬学会年会要旨集, Mar. 2016
      • Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells
        Shoichi Takagi; Yuki Takahashi; Kanako Sugimura; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 2016, Peer-reviewed
      • Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion (vol 5, 14979, 2015)
        Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yoshinobu Takakura; Makiya Nishikawa
        SCIENTIFIC REPORTS, Jan. 2016, Peer-reviewed
      • Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS
        Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jan. 2016, Peer-reviewed
      • Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids
        Kosuke Kusamori; Makiya Nishikawa; Narumi Mizuno; Tomoko Nishikawa; Akira Masuzawa; Yutaro Tanaka; Yuya Mizukami; Kazunori Shimizu; Satoshi Konishi; Yuki Takahashi; Yoshinobu Takakura
        PHARMACEUTICAL RESEARCH, Jan. 2016, Peer-reviewed
      • Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells
        Yu Nishida; Shozo Ohtsuki; Yuki Araie; Yuka Umeki; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Jan. 2016, Peer-reviewed
      • Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation
        Takuma Yamashita; Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Jan. 2016, Peer-reviewed
      • Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells
        Yu Nishida; Shozo Ohtsuki; Yuki Araie; Yuka Umeki; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Jan. 2016, Peer-reviewed
      • Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids
        Kosuke Kusamori; Makiya Nishikawa; Narumi Mizuno; Tomoko Nishikawa; Akira Masuzawa; Yutaro Tanaka; Yuya Mizukami; Kazunori Shimizu; Satoshi Konishi; Yuki Takahashi; Yoshinobu Takakura
        PHARMACEUTICAL RESEARCH, Jan. 2016, Peer-reviewed
      • Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides in polypod-like structured DNA
        Tomoki Shiomi; Mengmeng Tan; Natsuki Takahashi; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        NANO RESEARCH, Dec. 2015, Peer-reviewed
      • Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion
        Tomoya Yata; Yuki Takahashi; Mengmeng Tan; Kumi Hidaka; Hiroshi Sugiyama; Masayuki Endo; Yoshinobu Takakura; Makiya Nishikawa
        SCIENTIFIC REPORTS, Oct. 2015, Peer-reviewed
      • Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells
        Shozo Ohtsuki; Noriyuki Matsuzaki; Kohta Mohri; Masayuki Endo; Tomoko Emura; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Kenichi Ishiyama; Norimitsu Kadowaki; Yoshinobu Takakura; Makiya Nishikawa
        NUCLEIC ACID THERAPEUTICS, Oct. 2015, Peer-reviewed
      • Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-Based Hydrogel with Adjuvant Activity
        Yuka Umeki; Kohta Mohri; Yohji Kawasaki; Hiroshi Watanabe; Rei Takahashi; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        ADVANCED FUNCTIONAL MATERIALS, Sep. 2015, Peer-reviewed
      • Contribution of epigenetic modifications to the decline in transgene expression from plasmid DNA in mouse liver
        Lei Zang; Makiya Nishikawa; Mitsuru Ando; Yuki Takahashi; Yoshinobu Takakura
        Pharmaceutics, 09 Aug. 2015, Peer-reviewed
      • Self-Assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells
        Kohta Mohri; Eri Kusuki; Shozo Ohtsuki; Natsuki Takahashi; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura; Makiya Nishikawa
        BIOMACROMOLECULES, Apr. 2015, Peer-reviewed
      • Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice
        Yumiko Ishii-Mizuno; Yuka Umeki; Yuki Takahashi; Yukinori Kato; Tetsuji Takabayashi; Shigeharu Fujieda; Yoshinobu Takakura; Makiya Nishikawa
        JOURNAL OF CONTROLLED RELEASE, Feb. 2015, Peer-reviewed
      • Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice
        Masaki Morishita; Yuki Takahashi; Makiya Nishikawa; Kohei Sano; Kana Kato; Takuma Yamashita; Takafumi Imai; Hideo Saji; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 2015, Peer-reviewed
      • Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice.
        Takafumi Imai; Yuki Takahashi; Makiya Nishikawa; Kana Kato; Masaki Morishita; Takuma Yamashita; Akihiro Matsumoto; Chonlada Charoenviriyakul; Yoshinobu Takakura
        Journal of extracellular vesicles, 2015, Peer-reviewed
      • Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation
        Heidie L. Frisco-Cabanos; Mizuki Watanabe; Naoki Okumura; Kosuke Kusamori; Naohiro Takemoto; Junichiro Takaya; Shin-ichi Sato; Sayumi Yamazoe; Yoshinobu Takakura; Shigeru Kinoshita; Makiya Nishikawa; Noriko Koizumi; Motonari Uesugi
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Oct. 2014, Peer-reviewed
      • Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon gamma gene transfer on interferon gamma-mediated antitumor activity
        K. W Watcharanurak; L. Zang; M. Nishikawa; K. Yoshinaga; Y. Yamamoto; Y. Takahashi; M. Ando; K. Saito; Y. Watanabe; Y. Takakura
        GENE THERAPY, Sep. 2014, Peer-reviewed
      • X-ray Scattering from Immunostimulatory Tetrapod-Shaped DNA in Aqueous Solution To Explore Its Biological Activity-Conformation Relationship
        Yusuke Sanada; Shunsuke Sakamoto; Tomoki Shiomi; Tadashi Okobira; Efstratios Mylonas; Noboru Ohta; Naoto Yagi; Makiya Nishikawa; Isamu Akiba; Yoshinobu Takakura; Kazuo Sakurai
        JOURNAL OF PHYSICAL CHEMISTRY B, Sep. 2014, Peer-reviewed
      • Streptavidin-biotin結合に基づいたexosome放射標識法によるexosome体内動態の定量的解析
        森下 将輝; 高橋 有己; 佐野 紘平; 西川 元也; 佐治 英郎; 高倉 喜信
        日本DDS学会学術集会プログラム予稿集, Jul. 2014
      • DNA nanotechnology-based development of delivery systems for bioactive compounds
        Kohta Mohri; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
        EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Jul. 2014, Peer-reviewed
      • Enhancement of Anticancer Effect of Interferon-gamma Gene Transfer against Interferon-gamma-Resistant Tumor by Depletion of Tumor-Associated Macrophages
        Tsuyoshi Kiyota; Yuki Takahashi; Kanitta Watcharanurak; Makiya Nishikawa; Saori Ohara; Mitsuru Ando; Yoshihiko Watanabe; Yoshinobu Takakura
        MOLECULAR PHARMACEUTICS, May 2014, Peer-reviewed
      • Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA
        Shota Uno; Makiya Nishikawa; Kohta Mohri; Yuka Umeki; Noriyuki Matsuzaki; Yuki Takahashi; Haruyuki Fujita; Norimitsu Kadowaki; Yoshinobu Takakura
        NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, May 2014, Peer-reviewed
      • Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery
        Makiya Nishikawa; Kohei Ogawa; Yuka Umeki; Kohta Mohri; Yohji Kawasaki; Hiroshi Watanabe; Natsuki Takahashi; Eri Kusuki; Rei Takahashi; Yuki Takahashi; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Apr. 2014, Peer-reviewed
      • Streptavidin-biotin結合を利用したexosomeの放射標識によるexosome体内動態定量的解析法の開発
        森下 将輝; 高橋 有己; 佐野 紘平; 西川 元也; 佐治 英郎; 高倉 喜信
        日本薬学会年会要旨集, Mar. 2014
      • Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression
        Yalei Yin; Yuki Takahashi; Norifumi Ebisuura; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF GENE MEDICINE, Mar. 2014, Peer-reviewed
      • Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer
        Yuki Takahashi; Mitsuru Ando; Makiya Nishikawa; Nobuhiko Hiraga; Michio Imamura; Kazuaki Chayama; Yoshinobu Takakura
        HUMAN GENE THERAPY CLINICAL DEVELOPMENT, Mar. 2014, Peer-reviewed
      • The perspective of DDS from the viewpoint of a basic researcher
        Yoshinobu Takakura
        Drug Delivery System, 2014, Peer-reviewed
      • Prevention of adverse events of interferon gamma gene therapy by gene delivery of interferon gamma-heparin-binding domain fusion protein in mice
        Mitsuru Ando; Yuki Takahashi; Takuma Yamashita; Mai Fujimoto; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura
        MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2014, Peer-reviewed
      • Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice
        Kosuke Kusamori; Makiya Nishikawa; Narumi Mizuno; Tomoko Nishikawa; Akira Masuzawa; Kazunori Shimizu; Satoshi Konishi; Yuki Takahashi; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Jan. 2014, Peer-reviewed
      • Expression Profile-Dependent Improvement of Insulin Sensitivity by Gene Delivery of Interleukin-6 in a Mouse Model of Type II Diabetes
        Hanae Mukumoto; Yuki Takahashi; Mitsuru Ando; Makiya Nishikawa; Yoshinobu Takakura
        MOLECULAR PHARMACEUTICS, Oct. 2013, Peer-reviewed
      • Gene Delivery of Albumin Binding Peptide-Interferon-gamma Fusion Protein with Improved Pharmacokinetic Properties and Sustained Biological Activity
        Noriko Miyakawa; Makiya Nishikawa; Yuki Takahashi; Mitsuru Ando; Masayuki Misaka; Yoshihiko Watanabe; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2013, Peer-reviewed
      • Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion
        Naohiro Takemoto; Tetsuya Suehara; Heidie L. Frisco; Shin-ichi Sato; Takuhito Sezaki; Kosuke Kusamori; Yoshinori Kawazoe; Sun Min Park; Sayumi Yamazoe; Yoshiyuki Mizuhata; Rintaro Inoue; Gavin J. Miller; Steen U. Hansen; Gordon C. Jayson; John M. Gardiner; Toshiji Kanaya; Norihiro Tokitoh; Kazumitsu Ueda; Yoshinobu Takakura; Noriyuki Kioka; Makiya Nishikawa; Motonari Uesugi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2013, Peer-reviewed
      • Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids
        Kazunori Shimizu; Kosuke Kusamori; Makiya Nishikawa; Narumi Mizuno; Tomoko Nishikawa; Akira Masuzawa; Shingo Katano; Yuki Takahashi; Yoshinobu Takakura; Satoshi Konishi
        JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Jun. 2013, Peer-reviewed
      • Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice
        K. Watcharanurak; M. Nishikawa; Y. Takahashi; K. Kabashima; R. Takahashi; Y. Takakura
        Gene Therapy, May 2013, Peer-reviewed
      • Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection
        Yuki Takahashi; Makiya Nishikawa; Haruka Shinotsuka; Yuriko Matsui; Saori Ohara; Takafumi Imai; Yoshinobu Takakura
        JOURNAL OF BIOTECHNOLOGY, May 2013, Peer-reviewed
      • Development of multicellular spheroid for cell-based therapy
        Kosuke Kusamori; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
        Drug Delivery System, Apr. 2013, Peer-reviewed
      • Control of Spatiotemporal Distribution of Interferon gamma by Genetically Fusing Functional Peptides
        Mitsuru Ando; Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2012, Peer-reviewed
      • Controlling the kinetics of interferon transgene expression for improved gene therapy
        Kanitta Watcharanurak; Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
        JOURNAL OF DRUG TARGETING, Nov. 2012, Peer-reviewed
      • Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures
        Kohta Mohri; Natsuki Takahashi; Makiya Nishikawa; Eri Kusuki; Tomoki Shiomi; Yuki Takahashi; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Nov. 2012, Peer-reviewed
      • Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA
        Hiroyuki Yoshida; Makiya Nishikawa; Sachiyo Yasuda; Hiroyasu Toyota; Tsuyoshi Kiyota; Yuki Takahashi; Yoshinobu Takakura
        CYTOKINE, Oct. 2012, Peer-reviewed
      • Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation
        Sakulrat Rattanakiat; Makiya Nishikawa; Yoshinobu Takakura
        EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2012, Peer-reviewed
      • Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells
        Kohta Mohri; Makiya Nishikawa; Natsuki Takahashi; Tomoki Shiomi; Nao Matsuoka; Kohei Ogawa; Masayuki Endo; Kumi Hidaka; Hiroshi Sugiyama; Yuki Takahashi; Yoshinobu Takakura
        ACS NANO, Jul. 2012, Peer-reviewed
      • Near-Infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold
        Daihi Oushiki; Hirotatsu Kojima; Yuki Takahashi; Toru Komatsu; Takuya Terai; Kenjiro Hanaoka; Makiya Nishikawa; Yoshinobu Takakura; Tetsuo Nagano
        ANALYTICAL CHEMISTRY, May 2012, Peer-reviewed
      • Constant and steady transgene expression of interferon-gamma by optimization of plasmid construct for safe and effective interferon-gamma gene therapy
        Mitsuru Ando; Yuki Takahashi; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura
        JOURNAL OF GENE MEDICINE, Apr. 2012, Peer-reviewed
      • Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice
        Xin Guan; Makiya Nishikawa; Hisoon Li; Rei Takahashi; Yuki Takahashi; Yoshinobu Takakura
        Human Vaccines and Immunotherapeutics, Feb. 2012, Peer-reviewed
      • Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice
        Xin Guan; Makiya Nishikawa; Hisoon Li; Takahashi Rei; Yuki Takahashi; Yoshinobu Takakura
        HUMAN VACCINES & IMMUNOTHERAPEUTICS, Feb. 2012, Peer-reviewed
      • Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice
        Xin Guan; Makiya Nishikawa; Hisoon Li; Takahashi Rei; Yuki Takahashi; Yoshinobu Takakura
        HUMAN VACCINES & IMMUNOTHERAPEUTICS, Feb. 2012, Peer-reviewed
      • Development of safe and effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA vector
        Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        Frontiers in Bioscience - Scholar, 01 Jan. 2012, Peer-reviewed
      • Saturation of Transgene Protein Synthesis From mRNA in Cells Producing a Large Number of Transgene mRNA
        Yuki Takahashi; Makiya Nishikawa; Naomi Takiguchi; Tetsuya Suehara; Yoshinobu Takakura
        BIOTECHNOLOGY AND BIOENGINEERING, Oct. 2011, Peer-reviewed
      • Inhibition of nuclear delivery of plasmid DNA and transcription by interferon gamma: hurdles to be overcome for sustained gene therapy
        L. Zang; M. Nishikawa; K. Machida; M. Ando; Y. Takahashi; Y. Watanabe; Y. Takakura
        GENE THERAPY, Sep. 2011, Peer-reviewed
      • Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice
        Chika Nishizaki; Makiya Nishikawa; Tomoya Yata; Toshiyuki Yamada; Yuki Takahashi; Masahide Oku; Hiroya Yurimoto; Yasuyoshi Sakai; Kenji Nakanishi; Yoshinobu Takakura
        FREE RADICAL BIOLOGY AND MEDICINE, Aug. 2011, Peer-reviewed
      • Increase in CpG DNA-induced inflammatory responses by DNA oxidation in macrophages and mice
        Hiroyuki Yoshida; Makiya Nishikawa; Tsuyoshi Kiyota; Hiroyasu Toyota; Yoshinobu Takakura
        FREE RADICAL BIOLOGY AND MEDICINE, Jul. 2011, Peer-reviewed
      • Prolonged Circulation Half-life of Interferon gamma Activity by Gene Delivery of Interferon gamma-Serum Albumin Fusion Protein in Mice
        Noriko Miyakawa; Makiya Nishikawa; Yuki Takahashi; Mitsuru Ando; Masayuki Misaka; Yoshihiko Watanabe; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 2011, Peer-reviewed
      • Positive Correlation Between the Generation of Reactive Oxygen Species and Activation/Reactivation of Transgene Expression After Hydrodynamic Injections into Mice
        Naomi Takiguchi; Yuki Takahashi; Makiya Nishikawa; Yuriko Matsui; Yasushi Fukuhara; Daihi Oushiki; Kazuki Kiyose; Kenjiro Hanaoka; Tetsuo Nagano; Yoshinobu Takakura
        PHARMACEUTICAL RESEARCH, Apr. 2011, Peer-reviewed
      • Nucleic Acid Drug Delivery and Targeting
        Yoshinobu Takakura
        PHARMACEUTICAL RESEARCH, Apr. 2011, Peer-reviewed
      • 5 '-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages
        Hiroyuki Yoshida; Makiya Nishikawa; Tsuyoshi Kiyota; Shota Uno; Hiroyasu Toyota; Rei Takahashi; Miwako Narita; Yoshinobu Takakura
        EUROPEAN JOURNAL OF IMMUNOLOGY, Feb. 2011, Peer-reviewed
      • Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice
        Makiya Nishikawa; Yumiko Mizuno; Kohta Mohri; Nao Matsuoka; Sakulrat Rattanakiat; Yuki Takahashi; Hisakage Funabashi; Dan Luo; Yoshinobu Takakura
        BIOMATERIALS, Jan. 2011, Peer-reviewed
      • Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides
        Nao Matsuoka; Makiya Nishikawa; Kohta Mohri; Sakulrat Rattanakiat; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Dec. 2010, Peer-reviewed
      • Optimization of Gene Therapy Effect by Spaciotemporal Control of Expressed Proteins
        Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Nov. 2010, Peer-reviewed
      • Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors
        Yuki Takahashi; Elin Vikman; Makiya Nishikawa; Mitsuru Ando; Yoshihiko Watanabe; Yoshinobu Takakura
        JOURNAL OF GENE MEDICINE, Sep. 2010, Peer-reviewed
      • Enhanced Generation of Cytotoxic T Lymphocytes by Heat Shock Protein 70 Fusion Proteins Harboring Both CD8(+) T Cell and CD4(+) T Cell Epitopes
        Seiji Takemoto; Makiya Nishikawa; Xin Guan; Yuji Ohno; Tomoya Yata; Yoshinobu Takakura
        MOLECULAR PHARMACEUTICS, Sep. 2010, Peer-reviewed
      • DNA-based nano-sized systems for pharmaceutical and biomedical applications
        Makiya Nishikawa; Sakulrat Rattanakiat; Yoshinobu Takakura
        ADVANCED DRUG DELIVERY REVIEWS, Apr. 2010, Peer-reviewed
      • Bootstrap Method-Based Estimation of the Minimum Sample Number for Obtaining Pharmacokinetic Parameters in Preclinical Experiments
        Seiji Takemoto; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshitaka Yano; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Apr. 2010, Peer-reviewed
      • Development of a novel Hsp70-based DNA vaccine as a multifunctional antigen delivery system
        Ayumi Yamaoka; Xin Guan; Seiji Takemoto; Yoshinobu Takakura
        Journal of Controlled Release, 19 Mar. 2010, Peer-reviewed
      • Sustained Exogenous Expression of Therapeutic in Levels of IFN-gamma Ameliorates Atopic Dermatitis in NC/Nga Mice via Th1 Polarization
        Kayoko Hattori; Makiya Nishikawa; Kanitta Watcharanurak; Akihiko Ikoma; Kenji Kabashima; Hiroyasu Toyota; Yuki Takahashi; Rei Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura
        JOURNAL OF IMMUNOLOGY, Mar. 2010, Peer-reviewed
      • Comparison of the Type of Liposome Involving Cytokine Production Induced by Non-CpG Lipoplex in Macrophages
        Sachiyo Yasuda; Hiroyuki Yoshida; Makiya Nishikawa; Yoshinobu Takakura
        MOLECULAR PHARMACEUTICS, Mar. 2010, Peer-reviewed
      • Injection site-dependent induction of immune response by DNA vaccine: comparison of skin and spleen as a target for vaccination
        Xin Guan; Makiya Nishikawa; Seiji Takemoto; Yuji Ohno; Tomoya Yata; Yoshinobu Takakura
        JOURNAL OF GENE MEDICINE, Mar. 2010, Peer-reviewed
      • Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice
        Makiya Nishikawa; Takayuki Otsuki; Atsushi Ota; Xin Guan; Seiji Takemoto; Yuki Takahashi; Yoshinobu Takakura
        MOLECULAR THERAPY, Feb. 2010, Peer-reviewed
      • Development of oligonucleotide-based nano-sized DDS
        Kohta Mohri; Makiya Nishikawa; Yuki Takahaski; Yoshinobu Takakura
        Drug Delivery System, 2010, Peer-reviewed
      • Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice
        Yumiko Mizuno; Tomoyuki Naoi; Makiya Nishikawa; Sakulrat Rattanakiat; Nobuko Hamaguchi; Mitsuru Hashida; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Jan. 2010, Peer-reviewed
      • Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase
        Tomoya Yata; Makiya Nishikawa; Chika Nishizaki; Masahide Oku; Hiroya Yurimoto; Yasuyoshi Sakai; Yoshinobu Takakura
        FREE RADICAL BIOLOGY AND MEDICINE, Dec. 2009, Peer-reviewed
      • The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity
        Sakulrat Rattanakiat; Makiya Nishikawa; Hisakage Funabashi; Dan Luo; Yoshinobu Takakura
        BIOMATERIALS, Oct. 2009, Peer-reviewed
      • TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice
        Hiroyuki Yoshida; Makiya Nishikawa; Sachiyo Yasuda; Yumiko Mizuno; Hiroyasu Toyota; Tsuyoshi Kiyota; Rei Takahashi; Yoshinobu Takakura
        JOURNAL OF GENE MEDICINE, Aug. 2009, Peer-reviewed
      • Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy
        Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        ADVANCED DRUG DELIVERY REVIEWS, Jul. 2009, Peer-reviewed
      • Towards therapeutic application of RNA-mediated gene regulation Preface
        Yoshinobu Takakura
        ADVANCED DRUG DELIVERY REVIEWS, Jul. 2009, Peer-reviewed
      • Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression
        Masaru Mitsui; Makiya Nishikawa; Lei Zang; Mitsuru Ando; Kayoko Hattori; Yuki Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura
        JOURNAL OF GENE MEDICINE, May 2009, Peer-reviewed
      • Effects of Methyl-beta-cyclodextrin Treatment on Secretion Profile of Interferon-beta and Zonula Occuludin-1 Architecture in Madin-Darby Canine Kidney Cell Monolayers
        Masato Maruyama; Kayo Ishida; Yoshihiko Watanabe; Makiya Nishikawa; Yoshinobu Takakura
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2009, Peer-reviewed
      • Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination
        Keiko Isaji; Atsushi Kawase; Mitsuhiro Matono; Xin Guan; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, May 2009, Peer-reviewed
      • Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis
        Makiya Nishikawa; Mitsuru Hashida; Yoshinobu Takakura
        ADVANCED DRUG DELIVERY REVIEWS, Apr. 2009, Peer-reviewed
      • Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation
        Seiji Takemoto; Makiya Nishikawa; Takayuki Otsuki; Ayumi Yamaoka; Kazuki Maeda; Atsushi Ota; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Apr. 2009, Peer-reviewed
      • Quantitative and Temporal Analysis of Gene Silencing in Tumor Cells Induced by Small Interfering RNA or Short Hairpin RNA Expressed from Plasmid Vectors
        Yuki Takahashi; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 2009, Peer-reviewed
      • Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice
        Yuki Takahashi; Makiya Nishikawa; Tetsuya Suehara; Naomi Takiguchi; Yoshinobu Takakura
        INTERNATIONAL JOURNAL OF CANCER, Nov. 2008, Peer-reviewed
      • Reactivation of Silenced Transgene Expression in Mouse Liver by Rapid, Large-Volume Injection of Isotonic Solution
        Makiya Nishikawa; Ayumi Nakayama; Yuki Takahashi; Yasushi Fukuhara; Yoshinobu Takakura
        HUMAN GENE THERAPY, Oct. 2008, Peer-reviewed
      • Cellular activation by plasmid DNA in various macrophages in primary culture
        Hiroyuki Yoshida; Makiya Nishikawa; Sachiyo Yasuda; Yumiko Mizuno; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Oct. 2008, Peer-reviewed
      • Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells
        Yuki Takahashi; Haruka Kaneda; Nana Takasuka; Kayoko Hattori; Makiya Nishikawa; Yoshinobu Takakura
        CANCER SCIENCE, Aug. 2008, Peer-reviewed
      • Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice
        Keiko Kako; Makiya Nishikawa; Hiroyuki Yoshida; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Aug. 2008, Peer-reviewed
      • Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation
        Makiya Nishikawa; Mitsuhiro Matono; Sakulrat Rattanakiat; Nao Matsuoka; Yoshinobu Takakura
        IMMUNOLOGY, Jun. 2008, Peer-reviewed
      • Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F-1 mice
        Yoshiyuki Ogawa; Takaharu Yoshinaga; Makiya Nishikawa; Yoshinobu Takakura
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2008, Peer-reviewed
      • Pharmacokinetic considerations regarding non-viral cancer gene therapy
        Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
        CANCER SCIENCE, May 2008, Peer-reviewed
      • Heat shock protein derivatives for delivery of antigens to antigen presenting cells
        Makiya Nishikawa; Seiji Takemoto; Yoshinobu Takakura
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 2008, Peer-reviewed
      • Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1 alpha expression in tumor cells and hepatocytes
        Y. Takahashi; M. Nishikawa; Y. Takakura
        GENE THERAPY, Apr. 2008, Peer-reviewed
      • Erratum: (Cancer Science (2008) (1650))
        Yuki Takahashi; Haruka Kaneda; Nana Takasuka; Kayoko Hattori; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura
        Cancer Science, 2008, Peer-reviewed
      • Design of PCR-amplified DNA fragments for in vivo gene delivery: Size-dependency on stability and transgene expression
        Kazuhiro Hirata; Makiya Nishikawa; Naoki Kobayashi; Yuki Takahashi; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2007, Peer-reviewed
      • Hsp-based tumor vaccines: State-of-the-art and future directions
        Yoshinobu Takakura; Seiji Takemoto; Makiya Nishikawa
        CURRENT OPINION IN MOLECULAR THERAPEUTICS, Aug. 2007, Peer-reviewed
      • Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA
        Hiroki Kawano; Makiya Nishikawa; Masaru Mitsui; Yuki Takahashi; Keiko Kako; Kiyoshi Yamaoka; Yoshihiko Watanabe; Yoshinobu Takakura
        INTERNATIONAL JOURNAL OF CANCER, Jul. 2007, Peer-reviewed
      • Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture
        Yuga Fukuhara; Tomoyuki Naoi; Yoshiyuki Ogawa; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 2007, Peer-reviewed
      • Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL 11) by chemical modification with polyethylene glycol
        Akira Takagi; Noboru Yamashita; Tatsunobu Yoshioka; Yuuki Takaishi; Kyoko Sano; Hideto Yamaguchi; Atsushi Maeda; Katsumi Saito; Yoshinobu Takakura; Mitsuru Hashida
        JOURNAL OF CONTROLLED RELEASE, Jun. 2007, Peer-reviewed
      • Action mechanism of tachyplesin I and effects of PEGylation
        Yuichi Imura; Minoru Nishida; Yoshiyuki Ogawa; Yoshinobu Takakura; Katsumi Matsuzaki
        BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, May 2007, Peer-reviewed
      • Action mechanism of tachyplesin I and effects of PEGylation.
        Imura Y; Nishida M; Ogawa Y; Takakura Y; Matsuzaki K
        Biochimica et biophysica acta, May 2007, Peer-reviewed
      • DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells
        Takaharu Yoshinaga; Kei Yasuda; Yoshiyuki Ogawa; Makiya Nishikawa; Yoshinobu Takakura
        IMMUNOLOGY, Mar. 2007, Peer-reviewed
      • Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor
        Susumu Nagayama; Ken-ichi Ogawara; Keiko Minato; Yoshiko Fukuoka; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Feb. 2007, Peer-reviewed
      • Novel material and strategy for gene delivery
        Hatakeyama Hiroto; Takahashi Yuki; NISHIKAWA Makiya; TAKAKURA Yoshinobu
        JOURNAL-PHARMACEUTICAL SOCIETY OF JAPAN, 2007, Peer-reviewed
      • Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery
        Makiya Nishikawa; Seiii Takemoto; Yoshinobu Takakura
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007, Peer-reviewed
      • In vivo siRNA delivery to tumor cells and its application to cancer gene therapy
        Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007, Peer-reviewed
      • Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery
        Yasuomi Yamasaki; Tomoko Ikenaga; Takayuki Otsuki; Makiya Nishikawa; Yoshinobu Takakura
        VACCINE, Jan. 2007, Peer-reviewed
      • Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1 alpha
        Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        JOURNAL OF CONTROLLED RELEASE, Nov. 2006, Peer-reviewed
      • Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL 11)
        Akira Takagi; Noboru Yamashita; Tatsunobu Yoshioka; Yuuki Takaishi; Kiyo Nakanishi; Shigeo Takemura; Atsushi Maeda; Katsumi Saito; Yoshinobu Takakura; Mitsuru Hashida
        JOURNAL OF CONTROLLED RELEASE, Oct. 2006, Peer-reviewed
      • Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice
        Atsushi Kawase; Keiko Isaji; Ayumi Yamaoka; Naoki Kobayashi; Makiya Nishikawa; Yoshinobu Takakura
        VACCINE, Jul. 2006, Peer-reviewed
      • Moment analysis for kinetics of gene silencing by RNA interference
        Y Takahashi; K Yamaoka; M Nishikawa; Y Takakura
        BIOTECHNOLOGY AND BIOENGINEERING, Mar. 2006, Peer-reviewed
      • Role of immunostimulatory DNA and TLR9 in gene therapy
        Kei Yasuda; Hermann Wagner; Yoshinobu Takakura
        CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2006, Peer-reviewed
      • Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments
        Seiji Takemoto; Kiyoshi Yamaoka; Makiya Nishikawa; Yoshinobu Takakura
        DRUG METABOLISM AND PHARMACOKINETICS, 2006, Peer-reviewed
      • Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference
        Y Matsui; N Kobayashi; M Nishikawa; Y Takakura
        PHARMACEUTICAL RESEARCH, Dec. 2005, Peer-reviewed
      • Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes
        M Nishikawa; K Hyoudou; Y Kobayashi; Y Umeyama; Y Takakura; M Hashida
        JOURNAL OF CONTROLLED RELEASE, Dec. 2005, Peer-reviewed
      • Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages
        Yamane, I; M Nishikawa; Y Takakura
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Nov. 2005, Peer-reviewed
      • The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F-1 mice
        Y Ogawa; T Yoshinaga; K Yasuda; M Nishikawa; Y Takakura
        IMMUNOLOGY LETTERS, Oct. 2005, Peer-reviewed
      • Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: Quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases
        Y Takahashi; M Nishikawa; N Kobayashi; Y Takakura
        JOURNAL OF CONTROLLED RELEASE, Jul. 2005, Peer-reviewed
      • Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells
        M Maruyama; M Kishimoto; K Ishida; Y Watanabe; M Nishikawa; S Masuda; R Sasaki; Y Takakura
        ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Jun. 2005, Peer-reviewed
      • Gene Therapy and Gene Delivery
        Naoki Kobayashi; Makiya Nishikawa; Yoshinobu Takakura
        Drug Delivery: Principles and Applications, 13 May 2005, Peer-reviewed
      • Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule
        A Kawase; N Kobayashi; K Isaji; M Nishikawa; Y Takakura
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 2005, Peer-reviewed
      • Theoretical considerations involving the pharmacokinetics of plasmid DNA
        M Nishikawa; Y Takakura; M Hashida
        ADVANCED DRUG DELIVERY REVIEWS, Apr. 2005, Peer-reviewed
      • The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels
        N Kobayashi; M Nishikawa; Y Takakura
        ADVANCED DRUG DELIVERY REVIEWS, Apr. 2005, Peer-reviewed
      • Pharmacokinetics in gene delivery
        Y Takakura; M Hashida
        ADVANCED DRUG DELIVERY REVIEWS, Apr. 2005, Peer-reviewed
      • Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice
        S Takemoto; M Nishikawa; Y Takakura
        PHARMACEUTICAL RESEARCH, Mar. 2005, Peer-reviewed
      • Evaluation of the immune response after administration of plasmid DNA-non-viral vector complexes
        Fuminori Sakurai; Yoshinobu Takakura; Mitsuru Hashida
        Non-viral Gene Therapy: Gene Design and Delivery, 2005, Peer-reviewed
      • Permeability modulation of human intestinal Caco-2 cell monolayers by interferons
        H Kawaguchi; Y Akazawa; Y Watanabe; Y Takakura
        EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Jan. 2005, Peer-reviewed
      • Pharmacokinetics of Plasmid DNA-Based Non-viral Gene Medicine
        Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
        NON-VIRAL VECTORS FOR GENE THERAPY, 2ND EDITION: PART 1, 2005, Peer-reviewed
      • Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways
        K Yasuda; Y Ogawa; Yamane, I; M Nishikawa; Y Takakura
        JOURNAL OF LEUKOCYTE BIOLOGY, Jan. 2005, Peer-reviewed
      • Subcellular trafficking of exogenously expressed interferon-beta in Madin-Darby canine kidney cells
        M Maruyama; T Nishio; T Kato; T Yoshida; C Ishida; Y Watanabe; M Nishikawa; Y Kaneda; Y Takakura
        JOURNAL OF CELLULAR PHYSIOLOGY, Oct. 2004, Peer-reviewed
      • Secretion mode and subcellular localization of human interferon-beta exogenously expressed in porcine renal epithelial LLC-PK1 cells
        T Nishio; M Maruyama; T Yoshida; Y Watanabe; M Nishikawa; Y Takakura
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2004, Peer-reviewed
      • Simultaneous detection of DsRed2-tagged and EGFP-tagged human beta-interferons in the same single cells
        M Maruyama; T Nishio; T Yoshida; C Ishida; K Ishida; Y Watanabe; M Nishikawa; Y Takakura
        JOURNAL OF CELLULAR BIOCHEMISTRY, Oct. 2004, Peer-reviewed
      • Exogenous expression of interferon-beta in cultured brain microvessel endothelial cells
        M Nakamura; S Yamaguchi; Y Watanabe; F Yamashita; Y Takakura; M Hashida
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2004, Peer-reviewed
      • Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection
        J Hisazumi; N Kobayashi; M Nishikawa; Y Takakura
        PHARMACEUTICAL RESEARCH, Jul. 2004, Peer-reviewed
      • Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen
        T Ikenaga; Y Yamasaki; K Shakushiro; M Nishikawa; Y Takakura
        VACCINE, Jun. 2004, Peer-reviewed
      • Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells
        K Shakushiro; Y Yamasaki; M Nishikawa; Y Takakura
        IMMUNOLOGY, Jun. 2004, Peer-reviewed
      • Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor
        K Furumoto; S Nagayama; K Ogawara; Y Takakura; M Hashida; K Higaki; T Kimura
        JOURNAL OF CONTROLLED RELEASE, May 2004, Peer-reviewed
      • Hyrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: implication of a nonspecific process in efficient intracellular gene delivery
        N Kobayashi; M Nishikawa; K Hirata; Y Takakura
        JOURNAL OF GENE MEDICINE, May 2004, Peer-reviewed
      • Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: implications for particulate gene delivery systems
        N Kobayashi; K Hirata; S Chen; A Kawase; M Nishikawa; Y Takakura
        JOURNAL OF GENE MEDICINE, Apr. 2004, Peer-reviewed
      • Expression and visualization of a human interferon-beta-enhanced green fluorescent protein chimeric molecule in cultured cells
        M Nakamura; M Maruyama; F Yamashita; Y Takakura; M Hashida; Y Watanabe
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2004, Peer-reviewed
      • Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA
        K Yasuda; H Kawano; Yamane, I; Y Ogawa; T Yoshinaga; M Nishikawa; Y Takakura
        IMMUNOLOGY, Mar. 2004, Peer-reviewed
      • Vector-based in vivo RNA interference: Dose- and time-dependent suppression of transgene expression
        N Kobayashi; Y Matsui; A Kawase; K Hirata; M Miyagishi; K Taira; M Nishikawa; Y Takakura
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Feb. 2004, Peer-reviewed
      • An evaluation method for nonlinear local disposition in rat liver and kidney
        T Kato; K Yamaoka; Y Takakura
        DRUG METABOLISM AND DISPOSITION, Feb. 2004, Peer-reviewed
      • Sugars and dds
        Yoshinobu Takakura
        Drug Delivery System, 2004, Peer-reviewed
      • Effects of PEGylation on the activity of tachyplesin I
        Y Imura; M Nishida; Y Ogawa; Y Takakura; K Matsuzaki
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, Peer-reviewed
      • RNAi-based gene silencing in mice
        Makiya Nishikawa; Naoki Kobayashi; Yoshinobu Takakura
        Drug Delivery System, 2004, Peer-reviewed
      • Cancer gene therapy - Gene delivery research
        Y. Takakura
        Biotherapy, 2004, Peer-reviewed
      • Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo.
        K. Yamaoka; Y. Takakura
        Drug metabolism and pharmacokinetics, 2004, Peer-reviewed
      • Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice
        M Nishikawa; A Tamada; K Hyoudou; Y Umeyama; Y Takahashi; Y Kobayashi; H Kumai; E Ishida; F Staud; Y Yabe; Y Takakura; F Yamashita; M Hashida
        CLINICAL & EXPERIMENTAL METASTASIS, 2004, Peer-reviewed
      • Effect of interferon-gamma on the pharmacokinetics of digoxin, a P-glycoprotein substrate, intravenously injected into the mouse
        H Kawaguchi; Y Matsui; Y Watanabe; Y Takakura
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Jan. 2004, Peer-reviewed
      • Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes
        F Verbaan; van Dam, I; Y Takakura; M Hashida; W Hennink; G Storm; C Oussoren
        EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Dec. 2003, Peer-reviewed
      • Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study
        M Nishikawa; T Nakano; T Okabe; N Hamaguchi; Y Yamasaki; Y Takakura; F Yamashita; M Hashida
        BIOCONJUGATE CHEMISTRY, Sep. 2003, Peer-reviewed
      • Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I : poly C in a murine lung metastasis model
        F Sakurai; T Terada; M Maruyama; Y Watanabe; F Yamashita; Y Takakura; M Hashida
        CANCER GENE THERAPY, Sep. 2003, Peer-reviewed
      • In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes
        RI Mahato; K Kawabata; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, Jun. 2003, Peer-reviewed
      • Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice
        A Kawase; T Nomura; K Yasuda; N Kobayashi; M Hashida; Y Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 2003, Peer-reviewed
      • Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo
        M Anraku; U Kragh-Hansen; K Kawai; T Maruyama; Y Yamasaki; Y Takakura; M Otagiri
        PHARMACEUTICAL RESEARCH, Apr. 2003, Peer-reviewed
      • Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules
        Y Yamasaki; J Hisazumi; K Yamaoka; Y Takakura
        EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Apr. 2003, Peer-reviewed
      • Efficient uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism
        T Yoshinaga; K Yasuda; Y Ogawa; Y Takakura
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2002, Peer-reviewed
      • Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver
        Y Yabe; N Kobayashi; M Nishikawa; K Mihara; F Yamashita; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Dec. 2002, Peer-reviewed
      • Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models
        N Kobayashi; T Kuramoto; S Chen; Y Watanabe; Y Takakura
        MOLECULAR THERAPY, Dec. 2002, Peer-reviewed
      • Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat Hepatocytes
        Y Akazawa; H Kawaguchi; M Funahashi; Y Watanabe; K Yamaoka; M Hashida; Y Takakura
        JOURNAL OF PHARMACEUTICAL SCIENCES, Oct. 2002, Peer-reviewed
      • Important role of serum proteins associated on the surface of particles in their hepatic disposition
        K Furumoto; K Ogawara; S Nagayama; Y Takakura; M Hashida; K Higaki; T Kimura
        JOURNAL OF CONTROLLED RELEASE, Sep. 2002, Peer-reviewed
      • The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes
        F Sakurai; T Terada; K Yasuda; F Yamashita; Y Takakura; M Hashida
        GENE THERAPY, Aug. 2002, Peer-reviewed
      • Secretion polarity of interferon-beta in epithelial cell lines
        K Nakanishi; Y Watanabe; M Maruyama; F Yamashita; Y Takakura; M Hashida
        ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Jun. 2002, Peer-reviewed
      • Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: Importance of molecular size and negative charge density for in vivo recognition by receptors
        Y Yamasaki; K Sumimoto; M Nishikawa; F Yamashita; K Yamaoka; M Hashida; Y Takakura
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, May 2002, Peer-reviewed
      • Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes
        K Yasuda; Y Ogawa; M Kishimoto; T Takagi; M Hashida; Y Takakura
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2002, Peer-reviewed
      • Electrical charge on protein regulates its absorption from the rat small intestine
        M Nishikawa; S Hasegawa; F Yamashita; Y Takakura; M Hashida
        AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Apr. 2002, Peer-reviewed
      • Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery
        Y Takakura; M Nishikawa; F Yamashita; M Hashida
        JOURNAL OF DRUG TARGETING, Mar. 2002, Peer-reviewed
      • Effect of Co-administration of Cationic Macromolecules on the In Vivo Disposition and In situ Renal Disposition Characteristics of rhIL-11
        Akira Takagi; Yoshiyuki Yabe; Yoshikazu Oka; Yoshinobu Takakura; Mitsuru Hashida
        Drug Metabolism and Pharmacokinetics, 2002, Peer-reviewed
      • Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E-1 using lactosylated poly(L-glutamic hydrazide) as a carrier
        K Akamatsu; Y Yamasaki; M Nishikawa; Y Takakura; M Hashida
        BIOCHEMICAL PHARMACOLOGY, Dec. 2001, Peer-reviewed
      • Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats
        K Ogawara; K Furumoto; Y Takakura; M Hashida; K Higaki; T Kimura
        JOURNAL OF CONTROLLED RELEASE, Dec. 2001, Peer-reviewed
      • Cell-specific delivery of genes with glycosylated carriers
        M Hashida; M Nishikawa; F Yamashita; Y Takakura
        ADVANCED DRUG DELIVERY REVIEWS, Nov. 2001, Peer-reviewed
      • Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives
        Y Yabe; N Kobayashi; T Nishihashi; R Takahashi; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Sep. 2001, Peer-reviewed
      • Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system
        F Sakurai; T Nishioka; F Yamashita; Y Takakura; M Hashida
        EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Sep. 2001, Peer-reviewed
      • Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers
        Y Imamura; K Shimizu; F Yamashita; K Yamaoka; Y Takakura; M Hashida
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2001, Peer-reviewed
      • Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures
        N Kobayashi; T Kuramoto; K Yamaoka; M Hashida; Y Takakura
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Jun. 2001, Peer-reviewed
      • Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid
        F Sakurai; T Nishioka; H Saito; T Baba; A Okuda; O Matsumoto; T Taga; F Yamashita; Y Takakura; M Hashida
        GENE THERAPY, May 2001, Peer-reviewed
      • In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein
        P Opanasopit; K Shirashi; M Nishikawa; F Yamashita; Y Takakura; M Hashida
        AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, May 2001, Peer-reviewed
      • Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver
        K Furumoto; K Ogawara; M Yoshida; Y Takakura; M Hashida; K Higaki; T Kimura
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, May 2001, Peer-reviewed
      • Development of gene drug delivery systems based on pharmacokinetic studies
        Y Takakura; M Nishikawa; F Yamashita; M Hashida
        EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Apr. 2001, Peer-reviewed
      • The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration
        FJ Verbaan; C Oussoren; IM van Dam; Y Takakura; M Hashida; DJA Crommelin; WE Hennink; G Storm
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Feb. 2001, Peer-reviewed
      • Drug delivery systems and micromachines
        Yoshinobu Takakura; Kazuo Maruyama; Masayuki Yokoyama
        Drug Delivery System, 2001, Peer-reviewed
      • Tumor metastasis models
        Yoshinobu Takakura
        Drug Delivery System, 2001, Peer-reviewed
      • Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: A possible carrier for Kupffer cells
        P Opanasopit; M Nishikawa; F Yamashita; Y Takakura; N Hashida
        JOURNAL OF DRUG TARGETING, 2001, Peer-reviewed
      • Erratum: Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (Journal of Controlled Release 66 (2000) (255-269) PII: S0168365999002801)
        F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida
        Journal of Controlled Release, 03 Oct. 2000, Peer-reviewed
      • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
        T Kageyama; M Nakamura; A Matsuo; Y Yamasaki; Y Takakura; M Hashida; Y Kanai; M Naito; T Tsuruo; N Minato; S Shimohama
        BRAIN RESEARCH, Oct. 2000, Peer-reviewed
      • Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression
        F Sakurai; R Inoue; Y Nishino; A Okuda; O Matsumoto; T Taga; F Yamashita; Y Takakura; M Hashida
        JOURNAL OF CONTROLLED RELEASE, May 2000, Peer-reviewed
      • Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system
        S Nakajima; Y Koshino; T Nomura; F Yamashita; S Agrawal; Y Takakura; M Hashida
        ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, Apr. 2000, Peer-reviewed
      • Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system
        M Nishikawa; M Yamauchi; K Morimoto; E Ishida; Y Takakura; M Hashida
        GENE THERAPY, Apr. 2000, Peer-reviewed
      • Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting
        M Hashida; K Akamatsu; M Nishikawa; F Yamashita; H Yoshikawa; Y Takakura
        PHARMAZIE, Mar. 2000, Peer-reviewed
      • Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages
        T Takagi; M Hashiguchi; T Hiramatsu; F Yamashita; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, 2000, Peer-reviewed
      • Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice
        M Nishikawa; S Takemura; F Yamashita; Y Takakura; DKF Meijer; M Hashida; PJ Swart
        JOURNAL OF DRUG TARGETING, 2000, Peer-reviewed
      • Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages
        T Takagi; M Hashiguchi; T Hiramatsu; F Yamashita; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, 2000, Peer-reviewed
      • Design of polymeric prodrugs of prostaglandin E-1 having galactose residue for hepatocyte targeting
        M Hashida; K Akamatsu; M Nishikawa; F Yamashita; Y Takakura
        JOURNAL OF CONTROLLED RELEASE, Nov. 1999, Peer-reviewed
      • Interaction of polystyrene microspheres with liver cells: roles of membrane receptors and serum proteins
        K Ogawara; M Yoshida; Y Takakura; M Hashida; K Higaki; T Kimura
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Oct. 1999, Peer-reviewed
      • Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres
        K Ogawara; M Yoshida; J Kubo; M Nishikawa; Y Takakura; M Hashida; K Higaki; T Kimura
        JOURNAL OF CONTROLLED RELEASE, Sep. 1999, Peer-reviewed
      • Development of a hepatocyte-specific prostaglandin E-1 polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice
        K Akamatsu; Y Yamasaki; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Sep. 1999, Peer-reviewed
      • Disposition of radioactivity after injection of liver-targeted proteins labeled with In-111 or I-125. Effect of labeling on distribution and excretion of radioactivity in rats
        F Staud; M Nishikawa; K Morimoto; Y Takakura; M Hashida
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 1999, Peer-reviewed
      • Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution
        K Ogawara; M Yoshida; K Higaki; T Kimura; K Shiraishi; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF CONTROLLED RELEASE, May 1999, Peer-reviewed
      • Targeted delivery and improved therapeutic potential of catalase by chemical modification: Combination with superoxide dismutase derivatives
        Y Yabe; M Nishikawa; A Tamada; Y Takakura; M Hashida
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, May 1999, Peer-reviewed
      • Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation
        F Staud; M Nishikawa; Y Takakura; M Hashida
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Apr. 1999, Peer-reviewed
      • Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class a scavenger receptor knockout mice
        Y Takakura; T Takagi; M Hashiguchi; M Nisihikawa; F Yamashita; T Doi; T Imanishi; H Suzuki; T Kodama; M Hashida
        PHARMACEUTICAL RESEARCH, Apr. 1999, Peer-reviewed
      • Cell specific targeting of drugs and genes with glycosylated liposomes.
        M Hashida; M Nishikawa; F Yamashita; Y Takakura
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1999, Peer-reviewed
      • Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice
        H Masuda; Y Takakura; M Hashida
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Feb. 1999, Peer-reviewed
      • Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice
        M Nishikawa; F Staud; S Takemura; Y Takakura; M Hashida
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 1999, Peer-reviewed
      • Passive targeting with macromolecular drug carriers
        Yoshinobu Takakura
        Drug Delivery System, 1999, Peer-reviewed
      • Passive targeting of drug
        Yoshinobu Takakura; Kazuo Maruyama; Masayuki Yokoyama
        Drug Delivery System, 1999, Peer-reviewed
      • Stimulation side-dependent asymmetrical secretion of poly I : poly C-induced interferon-beta from polarized epithelial cell lines
        S Okamoto; K Nakanishi; Y Watanabe; F Yamashita; Y Takakura; M Hashida
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1999, Peer-reviewed
      • Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate
        H Yura; N Yoshimura; T Hamashima; K Akamatsu; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF CONTROLLED RELEASE, Jan. 1999, Peer-reviewed
      • Gene expression and antitumor effects following direct interferon (IFN)-gamma gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice
        T Nomura; K Yasuda; T Yamada; S Okamoto; RI Mahato; Y Watanabe; Y Takakura; M Hashida
        GENE THERAPY, Jan. 1999, Peer-reviewed
      • Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats
        K Ogawara; M Yoshida; K Furumoto; Y Takakura; M Hashida; K Higaki; T Kimura
        JOURNAL OF DRUG TARGETING, 1999, Peer-reviewed
      • Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: Quantitative comparison with other hepatotropic ligands
        KI Ogawara; S Hasegawa; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, 1999, Peer-reviewed
      • Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice
        Y Yabe; Y Koyama; M Nishikawa; Y Takakura; M Hashida
        FREE RADICAL RESEARCH, 1999, Peer-reviewed
      • Hepatic disposition characteristics of recombinant human interleukin-11 (rhIL-11) in the perfused rat liver
        A Takagi; Y Yabe; M Yoshida; Y Takakura; M Hashida
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 1998, Peer-reviewed
      • Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes
        S Kawakami; F Yamashita; M Nishikawa; Y Takakura; M Hashida
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1998, Peer-reviewed
      • Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I : poly C in mouse cell lines
        S Okamoto; Y Watanabe; Y Takakura; M Hashida
        JOURNAL OF BIOCHEMISTRY, Oct. 1998, Peer-reviewed
      • Targeted delivery of plasmid DNA to hepatocytes in vivo: Optimization of the pharmacokinetics of plasmid DNA galactosylated poly(L-lysine) complexes by controlling their physicochemical properties
        M Nishikawa; S Takemura; Y Takakura; M Hashida
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Oct. 1998, Peer-reviewed
      • Extravasation of macromolecules
        Y Takakura; RI Mahato; M Hashida
        ADVANCED DRUG DELIVERY REVIEWS, Oct. 1998, Peer-reviewed
      • Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems
        T Takino; N Koreeda; T Nomura; T Sakaeda; F Yamashita; Y Takakura; M Hashida
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 1998, Peer-reviewed
      • Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine)
        M Hashida; S Takemura; M Nishikawa; Y Takakura
        JOURNAL OF CONTROLLED RELEASE, Apr. 1998, Peer-reviewed
      • Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages
        T Takagi; M Hashiguchi; RI Mahato; H Tokuda; Y Takakura; M Hashida
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 1998, Peer-reviewed
      • Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells
        M Nakamura; P Davila-Zavala; H Tokuda; Y Takakura; M Hashida
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 1998, Peer-reviewed
      • Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection
        Takehiko Nomura; Akira Saikawa; Satoko Morita; Toshiyuki Sakaeda; Fumiyoshi Yamashita; Kazuo Honda; Yoshinobu Takakura; Mitsuru Hashida
        Journal of Controlled Release, 31 Mar. 1998, Peer-reviewed
      • Cellular uptake properties of oligonucleotides in LLC-PK1 renal epithelial cells
        Y Takakura; Y Oka; M Hashida
        ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, Feb. 1998, Peer-reviewed
      • Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver
        K Ogawara; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF CONTROLLED RELEASE, Jan. 1998, Peer-reviewed
      • Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors
        T Nomura; N Koreeda; F Yamashita; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Jan. 1998, Peer-reviewed
      • Drug delivery systems in gene therapy
        Y. Takakura
        Nippon rinsho. Japanese journal of clinical medicine, 1998, Peer-reviewed
      • Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier
        K Akamatsu; M Imai; Y Yamasaki; M Nishikawa; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, 1998, Peer-reviewed
      • Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes
        T Kanamaru; T Takagi; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, 1998, Peer-reviewed
      • Synthesis and biodistribution study of liver-specific prostaglandin E-1 polymeric conjugate
        K Akamatsu; M Nishikawa; Y Takakura; M Hashida
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Sep. 1997, Peer-reviewed
      • Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer
        T Nomura; S Nakajima; K Kawabata; F Yamashita; Y Takakura; M Hashida
        CANCER RESEARCH, Jul. 1997, Peer-reviewed
      • Effects of skin metabolism on percutaneous penetration of lipophilic drugs
        H Bando; S Mohri; F Yamashita; Y Takakura; M HAshida
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 1997, Peer-reviewed
      • Targeted delivery of drugs and proteins to the liver via receptor-mediated endocytosis
        M Hashida; H Hirabayashi; M Nishikawa; Y Takakura
        JOURNAL OF CONTROLLED RELEASE, May 1997, Peer-reviewed
      • Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver
        H Furitsu; K Ogawara; T Fujita; F Yamashita; Y Takakura; H Sezaki; M Hashida
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, May 1997, Peer-reviewed
      • Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by direct cationization
        T Takagi; M Kitano; S Masuda; H Tokuda; Y Takakura; M Hashida
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Apr. 1997, Peer-reviewed
      • Non-polarized secretion of mouse interferon-beta from gene-transferred human intestinal Caco-2 cells
        K Kawabata; M Kondo; Y Watanabe; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Apr. 1997, Peer-reviewed
      • Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine)
        RI Mahato; S Takemura; K Akamatsu; M Nishikawa; Y Takakura; M Hashida
        BIOCHEMICAL PHARMACOLOGY, Mar. 1997, Peer-reviewed
      • A physiological role of interferon (IFN)-beta derived from tumor: Tumor growth of a mouse bladder carcinoma line MBT-2 is partially suppressed by autocrine IFN-beta
        K Kawabata; S Okamoto; Y Takakura; M Hashida; T Hashimura; Y Watanabe
        CANCER LETTERS, Feb. 1997, Peer-reviewed
      • Estimation of drug concentration profiles in skin based on a skin diffusion model
        Noritaka Seko; Hiroto Bando; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida
        Drug Delivery System, 1997, Peer-reviewed
      • Uptake characteristics of anionized and cationized proteins in brain microvessel endothelial cells
        H. Tokuda; H. Nagano; Y. Takakura; M. Hashida
        Pharmaceutical Sciences, 1997, Peer-reviewed
      • Nonviral vectors for in vivo gene delivery: Physicochemical and pharmacokinetic considerations
        RI Mahato; Y Takakura; M Hashida
        CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 1997, Peer-reviewed
      • Cancer gene therapy by direct intratumoral injection: Gene expression and intratumoral pharmacokinetics of plasmid dna
        T. Nomura; Y. Takakura; M. Hashida
        Japanese Journal of Cancer and Chemotherapy, 1997, Peer-reviewed
      • Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney
        A Takagi; Y Yabe; Y Oka; K Sawai; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Jan. 1997, Peer-reviewed
      • In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model
        H Bando; M Sahashi; F Yamashita; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Jan. 1997, Peer-reviewed
      • Development of targeted delivery systems for nucleic acid drugs
        RI Mahato; Y Takakura; M Hashida
        JOURNAL OF DRUG TARGETING, 1997, Peer-reviewed
      • In vivo skin penetration enhancement of acyclovir by theoretical design of prodrug-enhancer combination
        H Bando; M Sahashi; S Mohri; F Yamashita; Y Takakura; M Hashida
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Dec. 1996, Peer-reviewed
      • Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake
        K Sawai; RI Mahato; Y Oka; Y Takakura; M Hashida
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Oct. 1996, Peer-reviewed
      • Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system
        A Saikawa; T Nomura; F Yamashita; Y Takakura; H Sezaki; M Hashida
        PHARMACEUTICAL RESEARCH, Oct. 1996, Peer-reviewed
      • Pharmacokinetic evaluation of polymeric carriers
        M Nishikawa; Y Takakura; M Hashida
        ADVANCED DRUG DELIVERY REVIEWS, Sep. 1996, Peer-reviewed
      • Pharmacokinetics and targeted delivery of proteins and genes
        M Hashida; RI Mahato; K Kawabata; T Miyao; M Nishikawa; Y Takakura
        JOURNAL OF CONTROLLED RELEASE, Aug. 1996, Peer-reviewed
      • Delivery of plasmid DNA to endothelial cells
        Y Takakura; M Hashida
        EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Aug. 1996, Peer-reviewed
      • Development of drug delivery systems for macromolecular drugs
        Y Takakura
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jul. 1996, Peer-reviewed
      • Control of pharmacokinetic profiles of drug-macromolecule conjugates
        Y Takakura; RI Mahato; M Nishikawa; M Hashida
        ADVANCED DRUG DELIVERY REVIEWS, Jun. 1996, Peer-reviewed
      • Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific drug delivery
        H Hirabayashi; M Nishikawa; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Jun. 1996, Peer-reviewed
      • Analysis of in vitro skin penetration of acyclovir prodrugs based on a diffusion model with a metabolic process
        H Bando; M Sahashi; T Takagi; F Yamashita; Y Takakura; M Hashida
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 1996, Peer-reviewed
      • Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribution
        Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Jun. 1996, Peer-reviewed
      • Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system
        M Yoshida; RI Mahato; K Kawabata; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Apr. 1996, Peer-reviewed
      • Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one
        H Bando; T Takagi; F Yamashita; Y Takakura; M Hashida
        PHARMACEUTICAL RESEARCH, Mar. 1996, Peer-reviewed
      • Receptor-mediated cell specific delivery of drugs to the liver and kidney
        M Hashida; M Nishikawa; Y Takakura
        ADVANCED BIOMATERIALS IN BIOMEDICAL ENGINEERING AND DRUG DELIVERY SYSTEMS, 1996, Peer-reviewed
      • Theoretical design of skin penetration enhancement via prodrug-enhancer combination based on a diffusion model
        H Bando; F Yamashita; Y Takakura; M Hashida
        ADVANCED BIOMATERIALS IN BIOMEDICAL ENGINEERING AND DRUG DELIVERY SYSTEMS, 1996, Peer-reviewed
      • Development of delivery systems for antisense oligonucleotides
        Y Takakura; RI Mahato; T Nomura; K Sawai; M Yoshida; T Kanamaru; M Hashida
        ADVANCED BIOMATERIALS IN BIOMEDICAL ENGINEERING AND DRUG DELIVERY SYSTEMS, 1996, Peer-reviewed
      • Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats
        PU Jani; T Nomura; F Yamashita; Y Takakura; AT Florence; M Hashida
        JOURNAL OF DRUG TARGETING, 1996, Peer-reviewed
      • Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system
        Yoshinobu Takakura; Ram I. Mahato; Mitsunobu Yoshida; Taro Kanamaru; Mitsuru Hashida
        Antisense and Nucleic Acid Drug Development, 1996, Peer-reviewed
      • A deconvolution method for estimating the first-pass metabolism of orally administered drugs
        F Yamashita; H Bando; Y Takakura; M Hashida
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 1995, Peer-reviewed
      • Characterization of LLC-PK1 kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs
        Y Takakura; T Morita; M Fujikawa; M Hayashi; H Sezaki; M Hashida; RT Borchardt
        PHARMACEUTICAL RESEARCH, Dec. 1995, Peer-reviewed
      • DISPOSITION CHARACTERISTICS OF RECOMBINANT HUMAN INTERLEUKIN-11 AFTER A BOLUS INTRAVENOUS ADMINISTRATION IN MICE
        A TAKAGI; H MASUDA; Y TAKAKURA; M HASHIDA
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 1995, Peer-reviewed
      • PHYSICOCHEMICAL AND PHARMACOKINETIC CHARACTERISTICS OF PLASMID DNA CATIONIC LIPOSOME COMPLEXES
        RI MAHATO; K KAWABATA; T NOMURA; Y TAKAKURA; M HASHIDA
        JOURNAL OF PHARMACEUTICAL SCIENCES, Nov. 1995, Peer-reviewed
      • HEPATIC TARGETING OF DRUGS AND PROTEINS BY CHEMICAL MODIFICATION
        M HASHIDA; M NISHIKAWA; Y TAKAKURA
        JOURNAL OF CONTROLLED RELEASE, Sep. 1995, Peer-reviewed
      • THE FATE OF PLASMID DNA AFTER INTRAVENOUS-INJECTION IN MICE - INVOLVEMENT OF SCAVENGER RECEPTORS IN ITS HEPATIC-UPTAKE
        K KAWABATA; Y TAKAKURA; M HASHIDA
        PHARMACEUTICAL RESEARCH, Jun. 1995, Peer-reviewed
      • IN-VITRO CYTOTOXICITY OF MACROMOLECULES IN DIFFERENT CELL-CULTURE SYSTEMS
        S CHOKSAKULNIMITR; S MASUDA; H TOKUDA; Y TAKAKURA; M HASHIDA
        JOURNAL OF CONTROLLED RELEASE, Jun. 1995, Peer-reviewed
      • GALACTOSYLATED PROTEINS ARE RECOGNIZED BY THE LIVER ACCORDING TO THE SURFACE-DENSITY OF GALACTOSE MOIETIES
        M NISHIKAWA; C MIYAZAKI; F YAMASHITA; Y TAKAKURA; M HASHIDA
        AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, May 1995, Peer-reviewed
      • ANALYSIS OF IN-VIVO SKIN PENETRATION ENHANCEMENT BY OLEIC-ACID BASED ON A 2-LAYER DIFFUSION-MODEL WITH POLAR AND NONPOLAR ROUTES IN THE STRATUM-CORNEUM
        F YAMASHITA; Y KOYAMA; M KITANO; Y TAKAKURA; M HASHIDA
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 1995, Peer-reviewed
      • MACROMOLECULAR DRUG CARRIER SYSTEMS IN CANCER-CHEMOTHERAPY - MACROMOLECULAR PRODRUGS
        Y TAKAKURA; M HASHIDA
        CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, Mar. 1995, Peer-reviewed
      • DESIGN FOR CELL-SPECIFIC TARGETING OF PROTEINS UTILIZING SUGAR-RECOGNITION MECHANISM - EFFECT OF MOLECULAR-WEIGHT OF PROTEINS ON TARGETING EFFICIENCY
        M NISHIKAWA; H HIRABAYASHI; Y TAKAKURA; M HASHIDA
        PHARMACEUTICAL RESEARCH, Feb. 1995, Peer-reviewed
      • Biodistribution control of lipophilic drugs with lipid carrier system
        Toichi Takino; Noriko Koreeda; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida
        Drug Delivery System, 1995, Peer-reviewed
      • Development of delivery systems of DNA medicines and possible obstacles to be overcome
        Yoshinobu Takakura; Mitsuru Hashida
        Drug Delivery System, 1995, Peer-reviewed
      • Renal Disposition Characteristics of Oligonucleotides Modified at Terminal Linkages in the Perfused Rat Kidney
        Kenzo Sawai; Takenori Miyao; Yoshinobu Takakura; Mitsuru Hashida
        Antisense Research and Development, 1995, Peer-reviewed
      • Control of Disposition Characteristics of Proteins by Direct Cationization in Mice
        TAKUYA FUJITA; YOSHINOBU TAKAKURA; HITOSHI SEZAKI; MITSURU HASHIDA
        Pharmacy and Pharmacology Communications, 1995
      • IN-VIVO DISPOSITION CHARACTERISTICS OF PLASMID DNA COMPLEXED WITH CATIONIC LIPOSOMES
        RI MAHATO; K KAWABATA; Y TAKAKURA; M HASHIDA
        JOURNAL OF DRUG TARGETING, 1995, Peer-reviewed
      • PHARMACOKINETIC DISPOSITION ANALYSIS OF LIPOPHILIC DRUGS INJECTED WITH VARIOUS LIPID CARRIERS IN THE SINGLE-PASS RAT-LIVER PERFUSION SYSTEM
        T TAKINO; E NAGAHAMA; T SAKAEDA; F YAMASHITA; Y TAKAKURA; M HASHIDA
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jan. 1995, Peer-reviewed
      • Stability and Pharmacokinetic Characteristics of Oligonucleotides Modified at Terminal Linkages in Mice
        Takenori Miyao; Yoshinobu Takakura; Taishin Akiyama; Fumio Yoneda; Hitoshi Sezaki; Mitsuru Hashida
        Antisense Research and Development, 1995, Peer-reviewed
      • PHARMACOKINETICS IN DESIGN OF POLYMERIC DRUG-DELIVERY SYSTEMS
        M HASHIDA; Y TAKAKURA
        JOURNAL OF CONTROLLED RELEASE, Sep. 1994, Peer-reviewed
      • IMPROVEMENT OF THE PULMONARY ABSORPTION OF (ASU(1,7))-EEL CALCITONIN BY VARIOUS PROTEASE INHIBITORS IN RATS
        T MORITA; A YAMAMOTO; Y TAKAKURA; M HASHIDA; H SEZAKI
        PHARMACEUTICAL RESEARCH, Jun. 1994, Peer-reviewed
      • PHARMACOKINETICS OF SUCCINYLATED PROTEINS AND DEXTRAN SULFATE IN MICE - IMPLICATIONS FOR HEPATIC TARGETING OF PROTEIN DRUGS BY DIRECT SUCCINYLATION VIA SCAVENGER RECEPTORS
        Y TAKAKURA; T FUJITA; H FURITSU; M NISHIKAWA; H SEZAKI; M HASHIDA
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 1994, Peer-reviewed
      • TARGETED DELIVERY OF SUPEROXIDE-DISMUTASE TO MACROPHAGES VIA MANNOSE RECEPTOR-MEDIATED MECHANISM
        Y TAKAKURA; S MASUDA; H TOKUDA; M NISHIKAWA; M HASHIDA
        BIOCHEMICAL PHARMACOLOGY, Mar. 1994, Peer-reviewed
      • COMPARATIVE-ANALYSIS OF PERCUTANEOUS-ABSORPTION ENHANCEMENT BY D-LIMONENE AND OLEIC-ACID BASED ON A SKIN DIFFUSION-MODEL
        Y KOYAMA; H BANDO; F YAMASHITA; Y TAKAKURA; H SEZAKI; M HASHIDA
        PHARMACEUTICAL RESEARCH, Mar. 1994, Peer-reviewed
      • MANIPULATION OF RENAL DISPOSITION OF HUMAN RECOMBINANT SUPEROXIDE-DISMUTASE BY CHEMICAL MODIFICATION
        K MIHARA; K SAWAI; Y TAKAKURA; M HASHIDA
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 1994, Peer-reviewed
      • IN-VIVO AND IN-VITRO ANALYSIS OF SKIN PENETRATION ENHANCEMENT BASED ON A 2-LAYER DIFFUSION-MODEL WITH POLAR AND NONPOLAR ROUTES IN THE STRATUM-CORNEUM
        F YAMASHITA; H BANDO; Y KOYAMA; S KITAGAWA; Y TAKAKURA; M HASHIDA
        PHARMACEUTICAL RESEARCH, Feb. 1994, Peer-reviewed
      • CONTROL OF THE DISPOSITION PROFILES OF PROTEINS IN THE KIDNEY VIA CHEMICAL MODIFICATION
        Y TAKAKURA; K MIHARA; M HASHIDA
        JOURNAL OF CONTROLLED RELEASE, Jan. 1994, Peer-reviewed
      • Control of in vivo characteristics of gene and antisense DNA disposition
        Y. Takakura; T. Miyao; K. Kawabata; M. Hashida
        Japanese Journal of Cancer and Chemotherapy, 1994, Peer-reviewed
      • LONG CIRCULATING EMULSION CARRIER SYSTEMS FOR HIGHLY LIPOPHILIC DRUGS
        T TAKINO; K KONISHI; Y TAKAKURA; M HASHIDA
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 1994, Peer-reviewed
      • CONTROL OF IN-VIVO FATE OF ALBUMIN DERIVATIVES UTILIZING COMBINED CHEMICAL MODIFICATION
        T FUJITA; M NISHIKAWA; Y OHTSUBO; J OHNO; Y TAKAKURA; H SEZAKI; M HASHIDA
        JOURNAL OF DRUG TARGETING, 1994, Peer-reviewed
      • TARGETING DELIVERY OF PROTEIN DRUGS BY CHEMICAL MODIFICATION
        M HASHIDA; M NISHIKAWA; F YAMASHITA; Y TAKAKURA
        DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, Peer-reviewed
      • IMPROVEMENT OF THERAPEUTIC EFFECT OF HUMAN RECOMBINANT SUPEROXIDE-DISMUTASE ON ISCHEMIC ACUTE-RENAL-FAILURE IN THE RAT VIA CATIONIZATION AND CONJUGATION WITH POLYETHYLENE-GLYCOL
        K MIHARA; Y OKA; K SAWAI; Y TAKAKURA; M HASHIDA
        JOURNAL OF DRUG TARGETING, 1994, Peer-reviewed
      • SPECIFIC UPTAKE OF SUCCINYLATED PROTEINS VIA A SCAVENGER RECEPTOR-MEDIATED MECHANISM IN CULTURED BRAIN MICROVESSEL ENDOTHELIAL-CELLS
        H TOKUDA; S MASUDA; Y TAKAKURA; H SEZAKI; M HASHIDA
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 1993, Peer-reviewed
      • SYNTHESIS AND PHARMACOKINETICS OF A NEW LIVER-SPECIFIC CARRIER, GLYCOSYLATED CARBOXYMETHYL-DEXTRAN, AND ITS APPLICATION TO DRUG TARGETING
        M NISHIKAWA; A KAMIJO; T FUJITA; Y TAKAKURA; H SEZAKI; M HASHIDA
        PHARMACEUTICAL RESEARCH, Sep. 1993, Peer-reviewed
      • DISPOSITION CHARACTERISTICS OF PROTEIN DRUGS IN THE PERFUSED RAT-KIDNEY
        K MIHARA; T HOJO; M FUJIKAWA; Y TAKAKURA; H SEZAKI; M HASHIDA
        PHARMACEUTICAL RESEARCH, Jun. 1993, Peer-reviewed
      • Controlled Biodistribution of Highly Lipophilic Drugs with Various Parenteral Formulations
        Toichi Takino; Chisato Nakajima; Yoshinobu Takakura; Hitoshi Sezaki; Mitsuru Hashida
        JOURNAL OF DRUG TARGETING, 1993, Peer-reviewed
      • TARGETED DELIVERY OF HUMAN RECOMBINANT SUPEROXIDE-DISMUTASE BY CHEMICAL MODIFICATION WITH MONOSACCHARIDE AND POLYSACCHARIDE DERIVATIVES
        T FUJITA; M NISHIKAWA; C TAMAKI; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Dec. 1992, Peer-reviewed
      • THERAPEUTIC EFFECTS OF SUPEROXIDE-DISMUTASE DERIVATIVES MODIFIED WITH MONOSACCHARIDES OR POLYSACCHARIDES ON HEPATIC-INJURY INDUCED BY ISCHEMIA REPERFUSION
        T FUJITA; H FURITSU; M NISHIKAWA; Y TAKAKURA; H SEZAKI; M HASHIDA
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1992, Peer-reviewed
      • DISPOSITION CHARACTERISTICS OF MACROMOLECULES IN THE PERFUSED TISSUE-ISOLATED TUMOR PREPARATION
        H IMOTO; Y SAKAMURA; K OHKOUCHI; R ATSUMI; Y TAKAKURA; H SEZAKI; M HASHIDA
        CANCER RESEARCH, Aug. 1992, Peer-reviewed
      • DEMONSTRATION OF THE RECEPTOR-MEDIATED HEPATIC-UPTAKE OF DEXTRAN IN MICE
        M NISHIKAWA; F YAMASHITA; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACY AND PHARMACOLOGY, May 1992, Peer-reviewed
      • PREPARATION AND PROPERTIES OF THE IMMUNOCONJUGATE COMPOSED OF ANTI-HUMAN COLON CANCER MONOCLONAL-ANTIBODY AND MITOMYCIN C-DEXTRAN CONJUGATE
        A NOGUCHI; T TAKAHASHI; T YAMAGUCHI; K KITAMURA; Y TAKAKURA; M HASHIDA; H SEZAKI
        BIOCONJUGATE CHEMISTRY, Mar. 1992, Peer-reviewed
      • CHEMICAL MODIFICATION AND DISPOSITION OF PROTEINS AND PEPTIDES - BIOPHARMACEUTICAL ASPECTS
        H SEZAKI; Y TAKAKURA; M HASHIDA
        TOPICS IN PHARMACEUTICAL SCIENCES 1991, 1992, Peer-reviewed
      • PERMEABILITY OF MACROMOLECULES IN CULTURED ENDOTHELIAL AND TUMOR-CELL LAYERS ON MICROPOROUS MEMBRANES
        M MASEGI; N WAKABAYASHI; K SAGARA; Y TERAMURA; A YAMAMOTO; Y TAKAKURA; M HASHIDA; H SEZAKI
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jan. 1992, Peer-reviewed
      • Cultured brain microvessel endothelial cells as in vitro models of the blood-brain barrier.
        Y. Takakura; K.L. Audus; R.T. Borchardt
        NIDA research monograph, 1992, Peer-reviewed
      • HEXOSE UPTAKE IN PRIMARY CULTURES OF BOVINE BRAIN MICROVESSEL ENDOTHELIAL-CELLS .2. EFFECTS OF CONDITIONED MEDIA FROM ASTROGLIAL AND GLIOMA-CELLS
        Y TAKAKURA; AM TRAMMEL; SL KUENTZEL; TJ RAUB; A DAVIES; SA BALDWIN; RT BORCHARDT
        BIOCHIMICA ET BIOPHYSICA ACTA, Nov. 1991, Peer-reviewed
      • HEXOSE UPTAKE IN PRIMARY CULTURES OF BOVINE BRAIN MICROVESSEL ENDOTHELIAL-CELLS .1. BASIC CHARACTERISTICS AND EFFECTS OF D-GLUCOSE AND INSULIN
        Y TAKAKURA; SL KUENTZEL; TJ RAUB; A DAVIES; SA BALDWIN; RT BORCHARDT
        BIOCHIMICA ET BIOPHYSICA ACTA, Nov. 1991, Peer-reviewed
      • TISSUE DISTRIBUTION OF IN-111 LABELED URICASE CONJUGATED WITH CHARGED DEXTRANS AND POLYETHYLENE-GLYCOL
        T FUJITA; Y YASUDA; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACOBIO-DYNAMICS, Nov. 1991, Peer-reviewed
      • HEPATIC DISPOSITION CHARACTERISTICS OF IN-111 LABELED LACTOSAMINATED BOVINE SERUM-ALBUMIN IN RATS
        K NISHIDA; Y EGUCHI; T TAKINO; Y TAKAKURA; M HASHIDA; H SEZAKI
        PHARMACEUTICAL RESEARCH, Oct. 1991, Peer-reviewed
      • HEPATIC DISPOSITION CHARACTERISTICS OF ELECTRICALLY CHARGED MACROMOLECULES IN RAT INVIVO AND IN THE PERFUSED LIVER
        K NISHIDA; K MIHARA; T TAKINO; S NAKANE; Y TAKAKURA; M HASHIDA; H SEZAKI
        PHARMACEUTICAL RESEARCH, Apr. 1991, Peer-reviewed
      • TUMOR-LOCALIZATION AND INVIVO ANTITUMOR-ACTIVITY OF THE IMMUNOCONJUGATE COMPOSED OF ANTI-HUMAN COLON CANCER MONOCLONAL-ANTIBODY AND MITOMYCIN C-DEXTRAN CONJUGATE
        A NOGUCHI; T TAKAHASHI; T YAMAGUCHI; K KITAMURA; Y TAKAKURA; M HASHIDA; H SEZAKI
        JAPANESE JOURNAL OF CANCER RESEARCH, Feb. 1991, Peer-reviewed
      • Immunoconjugate of monoclonal antibody A7 and mitomycin C-dextran conjugate linked through thioether bond
        Akinori Noguchi; Toshio Takahashi; Kazuya Kitamura; Toskiharu Yamaguchi; Yoshinobu Takakura; Mitsuru Hashida; Hitoshi Sezaki
        Drug Delivery System, 1991, Peer-reviewed
      • Control of in vivo fate of protein drugs using chemical modification with sugars
        T. Fujita; Y. Takakura; M. Hashida; H. Sezaki
        Journal of Pharmacobio-Dynamics, 1991, Peer-reviewed
      • Blood—Brain Barrier: Transport Studies in Isolated Brain Capillaries and in Cultured Brain Endothelial Cells
        Yoshinobu Takakura; Kenneth L. Audus; Ronald T. Borchardt
        Advances in Pharmacology, 01 Jan. 1991, Peer-reviewed
      • EFFECT OF ELECTRIC CHARGE ON THE HEPATIC-UPTAKE OF MACROMOLECULES IN THE RAT-LIVER
        K NISHIDA; C TONEGAWA; S NAKANE; Y TAKAKURA; M HASHIDA; H SEZAKI
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Nov. 1990, Peer-reviewed
      • BIOCHEMICAL AND BIOPHARMACEUTICAL PROPERTIES OF MACROMOLECULAR CONJUGATES OF URICASE WITH DEXTRAN AND POLYETHYLENE-GLYCOL
        Y YASUDA; T FUJITA; Y TAKAKURA; M HASHIDA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, Jul. 1990, Peer-reviewed
      • BILIARY-EXCRETION OF MITOMYCIN-C DEXTRAN CONJUGATES IN RELATION TO PHYSICOCHEMICAL CHARACTERISTICS OF CARRIER DEXTRAN
        M HASHIDA; R ATSUMI; K NISHIDA; S NAKANE; Y TAKAKURA; H SEZAKI
        JOURNAL OF PHARMACOBIO-DYNAMICS, Jul. 1990, Peer-reviewed
      • DISPOSITION CHARACTERISTICS OF MACROMOLECULES IN TUMOR-BEARING MICE
        Y TAKAKURA; T FUJITA; M HASHIDA; H SEZAKI
        PHARMACEUTICAL RESEARCH, Apr. 1990, Peer-reviewed
      • DISPOSITION OF ANTICANCER DRUGS AFTER BOLUS ARTERIAL ADMINISTRATION IN A TISSUE-ISOLATED TUMOR PERFUSION SYSTEM
        K OHKOUCHI; H IMOTO; Y TAKAKURA; M HASHIDA; H SEZAKI
        CANCER RESEARCH, Mar. 1990, Peer-reviewed
      • ALTERATION OF BIOPHARMACEUTICAL PROPERTIES OF DRUGS BY THEIR CONJUGATION WITH WATER-SOLUBLE MACROMOLECULES - URICASE DEXTRAN CONJUGATE
        T FUJITA; Y YASUDA; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF CONTROLLED RELEASE, Jan. 1990, Peer-reviewed
      • PHYSICOCHEMICAL PROPERTIES AND ANTITUMOR ACTIVITIES OF POLYMERIC PRODRUGS OF MITOMYCIN-C WITH DIFFERENT REGENERATION RATES
        Y TAKAKURA; S MATSUMOTO; M HASHIDA; H SEZAKI
        JOURNAL OF CONTROLLED RELEASE, Oct. 1989, Peer-reviewed
      • CONTROL OF PHARMACEUTICAL PROPERTIES OF SOYBEAN TRYPSIN-INHIBITOR BY CONJUGATION WITH DEXTRAN .2. BIOPHARMACEUTICAL AND PHARMACOLOGICAL PROPERTIES
        Y TAKAKURA; T FUJITA; M HASHIDA; H MAEDA; H SEZAKI
        JOURNAL OF PHARMACEUTICAL SCIENCES, Mar. 1989, Peer-reviewed
      • CONTROL OF PHARMACEUTICAL PROPERTIES OF SOYBEAN TRYPSIN-INHIBITOR BY CONJUGATION WITH DEXTRAN .1. SYNTHESIS AND CHARACTERIZATION
        Y TAKAKURA; Y KANEKO; T FUJITA; M HASHIDA; H MAEDA; H SEZAKI
        JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 1989, Peer-reviewed
      • Comparison of polythylene glycol and dextran conjugation with protein drug
        Yoshinobu Takakura; Takuya Fujita; Mitsuru Hashida; Hitoshi Sezaki
        Drug Delivery System, 1989, Peer-reviewed
      • Design and evaluation of monoclonal antibody-antitumor agent conjugate
        Y. Takakura; M. Hashida; H. Sezaki; K. Honda; A. Noguchi; T. Takahashi
        Journal of Pharmacobio-Dynamics, 1989, Peer-reviewed
      • DISPOSITION OF A POLYMERIC PRODRUG OF MITOMYCIN-C, MITOMYCIN-C-DEXTRAN CONJUGATE, IN THE PERFUSED RAT-LIVER
        K SATO; K ITAKURA; K NISHIDA; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 1989, Peer-reviewed
      • Soluble macromolecular carriers for the delivery of antitumour drugs
        Hitoshi Sezaki; Yoshinobu Takakura; Mitsuru Hashida
        Advanced Drug Delivery Reviews, 1989, Peer-reviewed
      • CHARACTERIZATION OF A LIPOPHILIC PRODRUG OF 5-FLUOROURACIL WITH A CHOLESTEROL PROMOIETY AND ITS APPLICATION TO LIPOSOMES
        M HASHIDA; K SATO; Y TAKAKURA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 1988, Peer-reviewed
      • Strategy for tumor targeting by macromolecule-drug conjugates
        Yoshinobu Takakura; Takuya Fujita; Mitsuru Hashida; Hitoshi Sezaki
        Drug Delivery System, 1988, Peer-reviewed
      • Development of monoclonal antibody-drug conjugate A7-MMC utilizing dextran as intermediate carrier
        A. Noguchi; T. Takahashi; T. Yamaguchi; K. Kitamura; T. Yokota; Y. Takakura; M. Hashida; H. Sezaki
        International Journal of Immunopharmacology, 1988, Peer-reviewed
      • THE ACCUMULATION MECHANISM OF CATIONIC MITOMYCIN C-DEXTRAN CONJUGATES IN THE LIVER - INVIVO CELLULAR-LOCALIZATION AND INVITRO INTERACTION WITH HEPATOCYTES
        S NAKANE; S MATSUMOTO; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACY AND PHARMACOLOGY, Jan. 1988, Peer-reviewed
      • Control of Biopharmaceutical Properties by Dextran Conjugates
        Hitoshi Sezaki; Yoshinobu Takakura; Mitsuru Hashida
        JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, Jan. 1988, Peer-reviewed
      • DISPOSITION CHARACTERISTICS OF MITOMYCIN-C-DEXTRAN CONJUGATE IN NORMAL AND TUMOR-BEARING MUSCLES OF RABBITS
        R ATSUMI; K ENDO; T KAKUTANI; Y TAKAKURA; M HASHIDA; H SEZAKI
        CANCER RESEARCH, Nov. 1987, Peer-reviewed
      • CELLULAR INTERACTION AND INVITRO ANTITUMOR EFFECT OF VARIOUS MITOMYCIN-C PRODRUGS IN MITOMYCIN-C-RESISTANT L1210 LEUKEMIA-CELL LINES
        S MATSUMOTO; T SHIGEOKA; Y TAKAKURA; M HASHIDA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, Sep. 1987, Peer-reviewed
      • DISPOSITION AND TUMOR-LOCALIZATION OF MITOMYCIN-C DEXTRAN CONJUGATES IN MICE
        Y TAKAKURA; A TAKAGI; M HASHIDA; H SEZAKI
        PHARMACEUTICAL RESEARCH, Aug. 1987, Peer-reviewed
      • DEVELOPMENT OF A NOVEL POLYMERIC PRODRUG OF MITOMYCIN-C, MITOMYCIN-C-DEXTRAN CONJUGATE WITH ANIONIC CHARGE .2. DISPOSITION AND PHARMACOKINETICS FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION
        Y TAKAKURA; R ATSUMI; M HASHIDA; H SEZAKI
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 1987, Peer-reviewed
      • DEVELOPMENT OF A NOVEL POLYMERIC PRODRUG OF MITOMYCIN-C, MITOMYCIN-C-DEXTRAN CONJUGATE WITH ANIONIC CHARGE .1. PHYSICOCHEMICAL CHARACTERISTICS AND INVIVO AND INVITRO ANTITUMOR ACTIVITIES
        Y TAKAKURA; M KITAJIMA; S MATSUMOTO; M HASHIDA; H SEZAKI
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 1987, Peer-reviewed
      • CELLULAR INTERACTION AND INVITRO ANTITUMOR-ACTIVITY OF MITOMYCIN C-DEXTRAN CONJUGATE
        S MATSUMOTO; A YAMAMOTO; Y TAKAKURA; M HASHIDA; N TANIGAWA; H SEZAKI
        CANCER RESEARCH, Sep. 1986, Peer-reviewed
      • ABSORPTION CHARACTERISTICS OF MACROMOLECULAR PRODRUGS OF MITOMYCIN-C FOLLOWING INTRAMUSCULAR ADMINISTRATION
        Y TAKAKURA; K MORI; M HASHIDA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, Apr. 1986, Peer-reviewed
      • CELLULAR INTERACTION AND ANTITUMOR-ACTIVITY OF MITOMYCIN-C PRODRUGS
        S MATSUMOTO; Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACOBIO-DYNAMICS, 1985, Peer-reviewed
      • FATE OF LIPID AND ENCAPSULATED DRUG AFTER INTRAMUSCULAR ADMINISTRATION OF LIPOSOMES PREPARED BY THE FREEZE-THAWING METHOD IN RATS
        T OHSAWA; Y MATSUKAWA; Y TAKAKURA; M HASHIDA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, Peer-reviewed
      • URINARY-EXCRETION CHARACTERISTICS OF A POLYMERIC PRODRUG OF MITOMYCIN-C, MITOMYCIN C-DEXTRAN CONJUGATE
        Y TAKAKURA; A KATO; M HASHIDA; K HONDA; A ARIMOTO; K SATOMURA; H SEZAKI
        JOURNAL OF PHARMACOBIO-DYNAMICS, 1985, Peer-reviewed
      • PLASMA DISPOSITION AND INVIVO AND INVITRO ANTITUMOR ACTIVITIES OF MITOMYCIN C-DEXTRAN CONJUGATE IN RELATION TO THE MODE OF ACTION
        S MATSUMOTO; Y ARASE; Y TAKAKURA; M HASHIDA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, Peer-reviewed
      • ANTITUMOR-ACTIVITY OF LIPOPHILIC PRODRUGS OF MITOMYCIN-C ENTRAPPED IN LIPOSOME OR O/W EMULSION
        H SASAKI; Y TAKAKURA; M HASHIDA; T KIMURA; H SEZAKI
        JOURNAL OF PHARMACOBIO-DYNAMICS, 1984, Peer-reviewed
      • DISPOSITION AND PHARMACOKINETICS OF A POLYMERIC PRODRUG OF MITOMYCIN-C, MITOMYCIN-C-DEXTRAN CONJUGATE, IN THE RAT
        M HASHIDA; A KATO; Y TAKAKURA; H SEZAKI
        DRUG METABOLISM AND DISPOSITION, 1984, Peer-reviewed
      • PHYSICOCHEMICAL AND ANTITUMOR CHARACTERISTICS OF SOME POLYAMINO ACID PRODRUGS OF MITOMYCIN-C
        CF ROOS; S MATSUMOTO; Y TAKAKURA; M HASHIDA; H SEZAKI
        INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1984, Peer-reviewed
      • ENHANCED LYMPHATIC DELIVERY OF MITOMYCIN-C CONJUGATED WITH DEXTRAN
        Y TAKAKURA; S MATSUMOTO; M HASHIDA; H SEZAKI
        CANCER RESEARCH, 1984, Peer-reviewed
      • REGENERATION CHARACTERISTICS OF MITOMYCIN C-DEXTRAN CONJUGATE IN RELATION TO ITS ACTIVITY
        M HASHIDA; Y TAKAKURA; S MATSUMOTO; H SASAKI; A KATO; T KOJIMA; S MURANISHI; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, 1983, Peer-reviewed
      • PHYSICOCHEMICAL AND ANTI-TUMOR CHARACTERISTICS OF HIGH MOLECULAR-WEIGHT PRODRUGS OF MITOMYCIN-C
        A KATO; Y TAKAKURA; M HASHIDA; T KIMURA; H SEZAKI
        CHEMICAL & PHARMACEUTICAL BULLETIN, 1982, Peer-reviewed

      Misc.

      • Significant advance in DDS science
        Yoshinobu Takakura
        Drug Delivery System, 2017
      • 自然免疫活性化による感染症予防を目的としたCpG DNA徐放DNAハイドロゲルの開発
        齋藤昌朗; 野村大貴; 菅田謙治; 松岡雅雄; 高橋洋介; 佐野紘平; 佐治英郎; 高橋有己; 高倉喜信; 西川元也
        日本核酸医薬学会年会講演要旨集, 01 Nov. 2016
      • For further evolution of drug delivery system
        Yoshinobu Takakura
        Drug Delivery System, 25 Apr. 2016
      • 先導的薬剤師養成に向けた実践的アドバンスト教育プログラムの共同開発 SP養成・PBLチュートリアル教育プログラム及び高度医療人養成・レギュラトリーサイエンスプログラム
        山下 富義; 入江 徹美; 新田 淳美; 高倉 喜信; 赤池 昭紀
        日本薬学会年会要旨集, Mar. 2016
      • エキソソームのマクロファージによる取り込みにおけるホスファチジルセリンの関与
        松本明宏; 高橋有己; 佐野紘平; 森下将輝; CHAROENVIRIYAKUL Chonlada; 西川元也; 佐治英郎; 高倉喜信
        日本薬学会年会要旨集(CD-ROM), 2016
      • 【生体膜シンポジウム「細胞外ベクシル・エクソソーム研究の最前線」】 DDSに資するエクソソームの開発
        森下 将輝; 高橋 有己; 西川 元也; 高倉 喜信
        膜, Sep. 2015
      • 先導的薬剤師養成に向けた実践的アドバンスト教育プログラムの共同開発 SP養成・PBLチュートリアル教育プログラム及び高度医療人養成・レギュラトリーサイエンスプログラム
        入江 徹美; 新田 淳美; 山下 富義; 栄田 敏之; 高倉 喜信; 赤池 昭紀
        日本薬学会年会要旨集, Mar. 2015
      • Towards the next decade, next two decade and further future
        Yoshinobu Takakura
        Drug Delivery System, 2015
      • 核酸医薬のための次世代DDS開発
        西川元也; 高橋有己; 高倉喜信
        PHARM TECH JAPAN, Jan. 2015
      • クローズアップ実験法 ハイドロダイナミクス法-高効率なin vivo遺伝子導入法
        高橋有己; 西川元也; 高倉喜信
        実験医学, Jan. 2015
      • X-ray scattering from tetrapod-shaped DNA in aqueous solution to determine its structures relating to biological activity
        Yusuke Sanada; Shunsuke Salamoto; Tomoki Shiomi; Tadashi Okobira; Efstratios Mylonas; Naoto Yagi; Makiya Nishikawa; Yoshinobu Takakura; Kazuo Sakurai
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014
      • 【脂質から形成されるナノマテリアル】 Exosomeの特性とexosomeを利用した診断・治療法の開発
        森下 将輝; 高橋 有己; 西川 元也; 高倉 喜信
        オレオサイエンス, Jul. 2014
      • Streptavidin-biotin結合を利用したexosomeの放射標識によるexosome体内動態定量的解析法の開発
        森下将輝; 高橋有己; 佐野紘平; 西川元也; 佐治英郎; 高倉喜信
        日本薬学会年会要旨集(CD-ROM), 2014
      • Streptavidin-biotin結合に基づいたexosome放射標識法によるexosome体内動態の定量的解析
        森下将輝; 高橋有己; 佐野紘平; 西川元也; 佐治英郎; 高倉喜信
        日本DDS学会学術集会プログラム予稿集, 2014
      • The 30th anniversary of the JSDDS
        Yoshinobu Takakura
        Drug Delivery System, 2014
      • Structural Analysis of Polypod DNA by Small-Angle X-ray
        Yusuke SANADA; Shunsuke SAKAMOTO; Tomoki SHIOMI; Tadashi OKOBIRA; Efstratios MYLONAS; Naoto YAGI; Makiya NISHIKAWA; Yoshinobu TAKAKURA; Kazuo SAKURAI
        第63回高分子学会年次大会, 2014
      • In vivo fate of exogenously-administered exosomes
        Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura
        Drug Delivery System, 2014, Peer-reviewed
      • バイオ医薬品の動態制御
        高橋有己; 西川元也; 高倉喜信
        薬剤学, 2014, Peer-reviewed
      • DNAハイドロゲル
        西川元也; 毛利浩太; 高倉喜信
        遺伝子医学MOOK別冊「ここまで広がるドラッグ徐放技術の最前線-古くて新しいドラッグデリバリーシステム(DDS)-」, Jan. 2013
      • Professor Mitsuru Hashida: His outstanding achievements in drug delivery research
        Yoshinobu Takakura
        JOURNAL OF DRUG TARGETING, Nov. 2012
      • Long-Term Elimination of Human Hepatitis C Virus in Human Hepatocyte Chimeric Mice after Single Administration of Plasmid DNA Expressing Human Interferon-gamma
        Yuki Takahashi; Misturu Ando; Makiya Nishikawa; Nobuhiko Hiraga; Michio Imamura; Kazuaki Chayama; Yoshinobu Takakura
        MOLECULAR THERAPY, May 2012
      • RNA干渉を利用した疾患治療システム
        高橋有己; 西川元也; 高倉喜信
        生体の科学, Mar. 2012
      • 機能性ペプチド融合によるInterferon ?時空間制御
        安藤満; 高橋有己; 西川元也; 高倉喜信
        YAKUGAKU ZASSHI, Jan. 2012
      • 核酸ナノデバイスの開発とDDS応用
        西川元也; 毛利浩太; 高橋有己; 高倉喜信
        遺伝子医学MOOK20号「ナノバイオ技術と最新創薬応用研究」, Jan. 2012
      • フォーラム 遺伝子・細胞製剤フォーカスグループの活動について
        西川元也; 高倉喜信
        薬剤学, Jan. 2012
      • DEVELOPMENT OF DNA NANOGELS AND HYDROGELS AS INJECTABLE DELIVERY SYSTEMS FOR CPG DNA AND OTHER NUCLEIC ACID-BASED DRUGS
        Makiya Nishikawa; Kohta Mohri; Kohei Ogawa; Natsuki Takahashi; Yuki Takahashi; Yoshinobu Takakura
        NUCLEIC ACID THERAPEUTICS, Oct. 2011
      • KINETIC COMPARISON OF GENE SILENCING PROFILE OF SIRNA AND SHRNA-EXPRESSING PLASMID DNA IN VIVO
        Yuki Takahashi; Yuriko Matsui; Makiya Nishikawa; Yoshinobu Takakura
        NUCLEIC ACID THERAPEUTICS, Oct. 2011
      • Activities of Gene & Cell Therapeutics Focus Group
        TAKAKURA Yoshinobu; NISHIKAWA Makiya
        薬剤学 = The archives of practical pharmacy, 01 Jul. 2010
      • 細胞親和性ペプチド融合による動態制御型ヒトカタラーゼの開発とその癌転移抑制効果
        西崎智香; 矢田智也; 西川元也; 奥公秀; 由里本博也; 阪井康能; 高倉喜信
        Drug Deliv Syst, 28 May 2010
      • Increasing the Duration of Transgene Expression of Interferon y for Amelioration of Atopic Dermatitis in NC/Nga Mice
        Kayoko Hattori; Makiya Nishikawa; Akihiko Ikoma; Kenji Kabashima; Rei Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura
        MOLECULAR THERAPY, May 2009
      • Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells (vol 99, pg 1650, 2008)
        Yuki Takahashi; Haruka Kaneda; Nana Takasuka; Kayoko Hattori; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura
        CANCER SCIENCE, Oct. 2008
      • IN VIVO ANTI-TUMOR EFFECTS OF PEG-MODIFIED LIPOSOMAL DOXORUBICIN ON p-GLYCOPROTEIN OVER-EXPRESSING TUMOR-BEARING MICE
        Keita Un; Takaaki Nakao; Ken-ichi Ogawara; Makiya Nishikawa; Yoshinobu Takakura; Kazutaka Higaki; Toshikiro Kimura
        DRUG METABOLISM REVIEWS, 2007
      • Delivery of vectors expressing short hairpin RNA for cancer therapy
        Makiya Nishikawa; Yuki Takahashi; Yoshinobu Takakura
        Drug Delivery System, 2007, Peer-reviewed
      • プラスミドベクターおよび投与方法の最適化によるインターフェロン遺伝子治療効果の増強
        町田一哉; 西川元也; 光井優; 高橋有己; 高倉喜信
        薬剤学= Journal of Pharmaceutical Science and Technology, Japan, 2007, Peer-reviewed
      • Induction of Antitumor Immunity by Cell-Penetrating Peptide-Coupled Hsp70 Gene Transfer to Tumor Cells
        Takayuki Otsuki; Makiya Nishikawa; Atsushi Ota; Seiji Takemoto; Yoshinobu Takakura
        MOLECULAR THERAPY, May 2006
      • Enhancement of Antitumor Activity of Interferons by RNAi-Mediated Silencing of SOCS Genes in Tumor Cells
        Yuki Takahashi; Haruka Kaneda; Makiya Nishikawa; Yoshinobu Takakura
        MOLECULAR THERAPY, May 2006
      • Increased Transgene Expression of Dystrophin in mdx Muscle by RNAi-Mediated Silencing of Calpain Expression
        Makiya Nishikawa; Kazuhiro Hirata; Kazuya Machida; Yuki Takahashi; Katsutoshi Yuasa; Shin'ichi Takeda; Yoshinobu Takakura
        MOLECULAR THERAPY, May 2006
      • Chemically modified catalase for prevention of ROS-mediated injury and tumor metastasis
        M Nishikawa; Y Takakura; M Hashida
        FEBS JOURNAL, Jul. 2005
      • Pharmacokinetics of Plasmid DNA-Based Non-viral Gene Medicine
        Makiya Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
        Advances in Genetics, 2005
      • RNAiベクターの生体への応用
        西川元也; 小林直樹; 高倉喜信
        Mol Med, Jan. 2004
      • Hydrodynamics法を用いたRNAiベクターの導入法
        高橋有己; 西川元也; 高倉喜信
        改訂RNAi実験プロトコール, Jan. 2004
      • siRNA・siRNA発現ベクターデリバリーシステム
        西川元也; 小林直樹; 高倉喜信
        遺伝子医学, Sep. 2003
      • Utilization of biological response against nonviral vectors for enhancing transgene expression
        M Nishikawa; T Kuramoto; T Okabe; Y Takakura; M Hashida
        MOLECULAR THERAPY, May 2003
      • Manipulation of immune responses by DNA vaccination through controlled local pharmacokinetics of DNA by complex formation with cationic macromolecule
        A Kawase; K Isaji; N Kobayashi; M Nishikawa; Y Takakura
        MOLECULAR THERAPY, May 2003
      • Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (vol 66, pg 255, 2000)
        F Sakurai; R Inoue; Y Nishino; A Okuda; O Matsumoto; T Taga; F Yamashita; Y Takakura; M Hashida
        JOURNAL OF CONTROLLED RELEASE, Oct. 2000
      • Cell-specific targeting of drugs and genes with glycosylated liposomes: Comparison with glycosylated poly(amino acids)
        M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura
        ACS Symposium Series, 2000, Peer-reviewed
      • Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate
        H Yura; N Yoshimura; T Hamashima; T Oka; Y Takakura; M Hashida
        TRANSPLANTATION PROCEEDINGS, Nov. 1998, Peer-reviewed
      • Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506 dextran conjugate
        H Yura; N Yoshimura; T Hamashima; T Oka; Y Takakura; M Hashida
        TRANSPLANTATION PROCEEDINGS, Jun. 1998, Peer-reviewed
      • Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506 dextran conjugate
        N Yoshimura; H Yura; T Hamashima; T Oka; Y Takakura; M Hadhida
        TRANSPLANTATION PROCEEDINGS, Jun. 1998, Peer-reviewed
      • スカベンジャー受容体ノックアウトマウスを用いたDNAの取り込み機構の解析
        高木 敏英; 橋口 美和; 土井 健史; 今西 武; 鈴木 宏志; 児玉 龍彦; 高倉 喜信; 橋田 充
        薬剤学, 05 Mar. 1998
      • ガラクトース修飾ポリ-L-グルタミン酸ヒドラジドを用いたprostaglandin E_1高分子化プロドラッグの体内動態とその肝炎治療効果
        赤松 憲; 山崎 泰臣; 西川 元也; 高倉 喜信; 橋田 充
        薬剤学, 05 Mar. 1998
      • 分子構造に基づく ab initio 薬物経皮吸収予測
        LIM Chee Wooi; 山下 富義; 高倉 喜信; 橋田 充
        薬剤学, 05 Mar. 1998
      • 受容体介在性エンドサイトーシスを利用した活性酸素分解酵素の細胞選択的同時ターゲティング
        矢部 義之; 玉田 あゆみ; 西川 元也; 高倉 喜信; 橋田 充
        薬剤学, 05 Mar. 1998
      • Pharmacokinetic Analysis of the in Vivo Disposition of Chemically Modified Proteins in Rats : Effect of Radiolabeling Method
        STAUD Frantisek; MORIMOTO Kensuke; NISHIKAWA Makiya; TAKAKURA Yoshinobu; HASHIDA Mitsuru
        薬剤学, 05 Mar. 1998
      • Polystyrene Microsphere の粒子サイズに依存した肝移行動態の解析
        吉田 実; 大河原 賢一; 久保 淳一; 檜垣 和孝; 木村 聰城郎; 白石 啓子; 高倉 喜信; 橋田 充
        薬剤学, 05 Mar. 1998
      • Incorporating mechanism of plasmid DNA in macrophage. Is the class A scavenger receptor involved ?
        高木敏英; 橋口美和; 高倉喜信; 橋田充; 土井健史; 今西武; 鈴木宏志; 児玉龍彦
        日本薬学会年会要旨集, Mar. 1998
      • Pharmacokinetic analysis of mannose receptor-mediated hepatic targeting of proteins: Capacity-limited hepatic uptake and saturable binding in plasma
        M. Nishikawa; P. Opanasopit; K. Shiraishi; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1998, Peer-reviewed
      • Disposition and gene expression of plasmid DNA complexed with cationic carriers
        RI Mahato; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Control of disposition characteristics of catalase by chemical modification
        Y Yabe; Y Koyama; M Nishikawa; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Pharmacokinetic evaluation of the in vivo disposition characteristics of protein drugs radiolabeled by different methods
        M Nishikawa; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • In vivo gene expression following direct injection of naked plasmid DNA into tumor
        T Nomura; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Renal disposition characteristics of unmodified and phosphorothioated antisense oligonucleotides in situ and in vitro
        Y Oka; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Pharmacokinetic analysis of hepatocyte-specific targeting of plasmid DNA using galactosylated poly-L-lysine
        S Takemura; M Nishikawa; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Analysis of in vivo skin penetration enhancement by prodrug-enhancer combination based on a diffusion/bioconversion model
        H Bando; M Sahashi; F Yamashita; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Pharmacokinetics and hepatic uptake mechanism of recombinant rat decorin after intravenous injection in mice
        H Masuda; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Biological activity and intracellular pharmacokinetics of antisense oligonucleotides: Effect of cationic liposomes
        T Takagi; T Kanamaru; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Hepatic disposition characteristics of glycosylated bovine serum albumin in rats
        K Ogawara; M Nishikawa; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • Interferon gene transfer into intestinal epithelial cells
        K Kawabata; Y Watanabe; Y Takakura; M Hashida
        23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed
      • 糖鎖認識機構を利用した細胞特異的薬物ターゲティング
        西川元也; 平林英樹; 高倉喜信; 橋田充
        PHARM TECH JAPAN, Jan. 1995
      • Molecular design of protein derivatives targeted to the liver via the asialoglycoprotein receptor
        M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1995, Peer-reviewed
      • Pharmacokinetic analysis of various lipid carrier systems after intratumoral injection in tissue-isolated tumors
        T. Nomura; F. Yamashita; Y. Takakura; N. Hashida
        Proceedings of the Controlled Release Society, 1995, Peer-reviewed
      • Targeted delivery of superoxide dismutase to macrophages by direct cationization
        Y. Takakura; T. Takagi; S. Masuda; M. Hashida
        Proceedings of the Controlled Release Society, 1995, Peer-reviewed
      • SKIN PENETRATION ENHANCEMENT OF ACYCLOVIR BY PRODRUG-ENHANCER COMBINATION
        H BANDO; F YAMASHITA; Y TAKAKURA; M HASHIDA
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 1994
      • In vivo stability and disposition characteristics of plasmid DNA
        K. Kawabata; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1994, Peer-reviewed
      • Uptake characteristics and cytotoxicity of plasmid DNA in cultured macrophages and endothelial cells
        H. Tokuda; S. Choksakulnimitr; S. Masuda; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1994, Peer-reviewed
      • 機構論に基づく吸収促進剤適用の最適化の試み
        山下 富義; 小山 靖夫; 坂東 博人; 高倉 喜信; 橋田 充
        Drug Delivery System, 1993
      • Inhibitory effect of superoxide dismutase derivatives modified with various sugar moieties on ischemia/reperfusion injury
        Hisao Furitsu; Yoshinobu Takakura; Mitsuru Hashida; Takuya Fujita; Hitoshi Sezaki
        Drug Delivery System, 1993
      • Disposition Characteristics of Model Macromolecules in the Perfused Rat Kidney
        Kiyoshi Mihara; Mihoko Mori; Takami Hojo; Yoshinobu Takakura; Mitsuru Hashida; Hitoshi Sezaki
        Biological and Pharmaceutical Bulletin, 1993
      • Targeted delivery of polyanions to the brain
        H. Tokuda; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1993, Peer-reviewed
      • Stability and in vivo disposition characteristics of oligonucleotides and oligonucleotide conjugated with macromolecule
        T. Miyao; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1993, Peer-reviewed
      • Comparison of action mechanism of penetration enhancers based on a skin diffusion model
        F. Yamashita; Y. Koyama; Y. Takakura; M. Hashida
        Proceedings of the Controlled Release Society, 1993, Peer-reviewed
      • MECHANISM OF HEPATIC-UPTAKE OF POLYMERIC PRODRUG OF MITOMYCIN-C, MITOMYCIN-C-DEXTRAN CONJUGATE
        Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACEUTICAL SCIENCES, Nov. 1987
      • ENHANCED LYMPHATIC DELIVERY OF MITOMYCIN-C BY POLYMERIC MODIFICATION
        Y TAKAKURA; M HASHIDA; H SEZAKI
        JOURNAL OF PHARMACOBIO-DYNAMICS, 1984

      Books and Other Publications

      • Diagnostic and Therapeutic Applications of Exosomes in Cance
        TAKAKURA Yoshinobu, Contributor
        Elsevier, 2018, Not refereed
      • Extracellular Vesicles
        TAKAKURA Yoshinobu, Contributor
        Wiley, 2017, Not refereed
      • 飛躍するDDSサイエンス
        高倉 喜信, Others
        Drug Delivery System,, 2017, Not refereed
      • 医療薬学 Ⅳ. 薬理・病態・薬物治療(4)(スタンダード薬学シリーズⅡ6)
        高倉 喜信, Contributor
        東京化学同人, 2017, Not refereed
      • パラダイムシフトをもたらすエクソソーム機能研究最前線
        高倉 喜信, Contributor
        NTS, 2017, Not refereed
      • くすりをつくる研究者の仕事
        高倉 喜信, Contributor
        化学同人, 2017, Not refereed
      • DDS 最近の進歩
        高倉 喜信, Others
        ファルマシア, 2016, Not refereed
      • エクソソームを利用したDDSの開発
        高倉 喜信, Others
        実験医学,, 2016, Not refereed
      • さらなるDDSの発展を目指して
        高倉 喜信, Others
        Drug Delivery System, 2016, Not refereed
      • バイオマテリアル:その基礎と先端研究への展開
        高倉 喜信, Contributor
        東京化学同人, 2016, Not refereed
      • 核酸医薬の創製と応用展開
        高倉 喜信, Contributor
        シーエムシー, 2016, Not refereed
      • 核酸医薬のためのデリバリー技術
        高倉 喜信, Others
        日本核酸医薬学会会誌, 2015, Not refereed
      • ドラッグデリバリーシステムとしてのエキソソーム
        高倉 喜信, Others
        細胞, 2015, Not refereed
      • ハイドロダイナミクス法:高効率なin vivo遺伝子導入法
        高倉 喜信, Others
        実験医学, 2015, Not refereed
      • 薬剤学慨史-私はこう見る 120人による俯瞰図
        高倉喜信, Contributor
        日本薬剤学会, 2015, Not refereed
      • 核酸医薬のための次世代DDS開発
        高倉 喜信, Others
        ファームテクジャパン, 2015, Not refereed
      • 発刊によせて
        高倉 喜信, Others
        ファームテクジャパン, 2015, Not refereed
      • 新薬展望2015 第1部 新薬創出における日本医療研究開発機構(AMED)の役割
        高倉 喜信, Others
        医薬ジャーナル, 2015, Not refereed
      • 10年後、20年後、そしてさらなる未来に向けて
        高倉 喜信, Others
        Drug Delivery System, 2015, Not refereed
      • 薬剤学実験法必携マニュアル―(分担執筆)
        高倉喜信, Contributor, 遺伝子製剤
        南江堂, Apr. 2014, Not refereed
      • オリゴ核酸を基盤とする多足型核酸構造体を利用した免疫刺激性核酸デリバリーシステムの開発
        高倉 喜信, Others
        Antisense, 2014, Not refereed
      • バイオ薬医の動態制御
        高倉 喜信, Others
        薬剤学, 2014, Not refereed
      • 30周年を迎えて
        高倉 喜信, Others
        Drug Delivery System, 2014, Not refereed
      • 細胞スフェロイド化技術の開発と細胞治療への応用
        高倉 喜信, Others
        Drug Delivery System, 2014, Not refereed
      • 細胞治療とDDS-細胞を制御する、細胞で制御するー
        高倉 喜信, Others
        Drug Delivery System, 2013, Not refereed
      • 日本のプレセンスを!
        高倉 喜信, Others
        Drug Delivery System, 2013, Not refereed
      • 応用が拡がるDDSー人体環境から農業・家電までー(分担執筆)
        高倉 喜信, Contributor, がん遺伝子治療
        NTS, 2013, Not refereed
      • 遺伝子・細胞製剤フォーカスグループの活動について
        高倉 喜信, Others
        薬剤学, 2012, Not refereed
      • RNA干渉を利用した疾患治療システム
        高倉 喜信, Others
        生体の科学, 2012, Not refereed
      • 薬剤学研究の将来ー薬学教育6年制導入から6年ー
        高倉 喜信, Others
        薬剤学, 2012, Not refereed
      • 昇り竜のごとく
        高倉 喜信, Others
        Drug Delivery System, 2012, Not refereed
      • 新しい薬学事典(分担執筆)
        高倉 喜信, Contributor, 遺伝子治療
        朝倉書店, 2012, Not refereed
      • DDSのさらなる発展のために
        高倉 喜信, Others
        Drug Delivery System, 2011, Not refereed
      • 次世代バイオ医薬品の製剤設計と開発戦略(分担執筆)
        高倉 喜信, Contributor, 第1章バイオ薬物ターゲティングの動態解析
        シーエムーシ, 2011, Not refereed
      • アジュバンド開発研究の新展開(分担執筆)
        高倉 喜信, Contributor, CpGDNAの立体化によるアジュバンド効果の増強
        シーエム-シー, 2011, Not refereed
      • 図解で学ぶDDS―薬物治療の最適化を目指す先端創薬技術(編集)
        高倉喜信; 橋田 充; 京; 高倉喜信; 学研究
        じほう, Aug. 2010, Not refereed
      • Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development,
        TAKAKURA Yoshinobu, Contributor
        Informa Healthcare, 2009, Not refereed
      • Polymeric Gene Delivery Principles and Applications
        TAKAKURA Yoshinobu, Contributor
        CRC Press, 2005, Not refereed
      • Drug Delivery: Principles and Applications
        TAKAKURA Yoshinobu, Contributor
        Wiley, 2005, Not refereed
      • Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics
        TAKAKURA Yoshinobu, Contributor
        Taylor & Francis, 2002, Not refereed
      • 生体内薬物送達学 (基礎生体工学講座)(共著)
        橋田 充; 高倉 喜信, Joint work
        産業図書, Oct. 1994, Not refereed
      • バイオコンジュゲート医薬品(分担執筆)
        髙倉 喜信
        廣川書店,, 1993, Not refereed

      Awards

      • 1995
        日本薬物動態学会奨励賞
      • 1996
        日本薬学会奨励賞
      • 2009
        AAPSフェロー
      • 2011
        タケル・アヤ・ヒグチ記念賞
      • May 2019
        日本薬剤学会賞

      External funds: Kakenhi

      • 細胞外小胞を利用した経鼻脳デリバリー法の開発
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 90:Biomedical engineering and related fields
        Kyoto University
        高倉 喜信
        From 09 Jul. 2021, To 31 Mar. 2023, Granted
        細胞外小胞
      • 樹状細胞由来細胞外小胞の免疫機能の最大化並びに動態制御に基づくワクチン療法開発
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
        Kyoto University
        高倉 喜信
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        細胞外小胞;エクソソーム;樹状細胞
      • 天然ステルスエキソソームの解析とデリバリーキャリア開発への応用
        Grant-in-Aid for Scientific Research (B)
        Basic Section 90120:Biomaterials-related
        Kyoto University
        高橋 有己
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        エキソソーム;血中滞留性;細胞外小胞
      • Development of in vivo gene therapy using exosomes loading immunomodulatory molecules
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
        Kyoto University
        Yoshinobu Takakura
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        エキソソーム;ルシフェラーゼ;免疫療法;サイトカイン;免疫;内因性
      • Development of cytokine gene therapy with high therapeutic index by systemic regulation of transgene expression and biological response.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Yoshinobu Takakura
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        遺伝子治療;サイトカイン;プラスミドDNA;ドラッグデリバリー;インターフェロン;抗原特異的免疫応答
      • Efficient induction of in vivo RNA interference by designing exosome-tropic siRNA derivatives
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Yuki Takahashi
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        エキソソーム;ラジオアイソトープ;DDS;SELEX法
      • Development of DDS applicable for immune therapy by using self-assembling RNA sponge particle
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Yoshinobu Takakura
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        ドラッグデリバリー;アジュバント;ワクチン;TLR3
      • Development of therapeutic systems based on three-dimensional DNA nanostructures
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Makiya Nishikawa
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        核酸;DNA;DDS;ハイドロゲル;抗原
      • Development of microtissue therapeutic system based on mixed multicellular spheroids
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Makiya NISHIKAWA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        細胞治療;スフェロイド;幹細胞;移植
      • Development of target-specific multifunctional exosomes loaded with RNA drugs
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Yuki TAKAHASHI
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        ドラッグデリバリー;エキソソーム;ルシフェラーゼ;イメージング;DDS
      • Optimization of cytokine gene therapy based on the regulation of transcription/translation, pharmacokinetics, and cellular response.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Yoshinobu TAKAKURA
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        ドラッグデリバリー;遺伝子治療;インターフェロン;IDO-1;腫瘍組織関連マクロファージ;抗原特異的免疫応答;サイトカイン;プラスミドDNA;融合タンパク質;RNA干渉
      • Development of targeted cell therapeutic systems based on cell characteristics
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Makiya NISHIKAWA
        From 28 Apr. 2011, To 31 Mar. 2013, Project Closed
        ドラッグデリバリー;細胞治療;体内分布;イメージング;細胞個性;細胞スフェロイド;PEG修飾
      • Development of nano-sized DDS for nucleic acid drugs based on polypod-like structured nucleic acids
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Makiya NISHIKAWA
        From 01 Apr. 2011, To 31 Mar. 2014, Project Closed
        核酸;ナノ粒子;DDS;CpG;siRNA
      • 一回の投与で繰り返しタンパク質を供給可能なオンデマンド型遺伝子治療システムの開発
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        高倉 喜信
        Project Closed
        遺伝子発現;肝臓;転写因子;非ウィルスベクター;物理刺激
      • 次世代細胞治療に向けた細胞製剤のステルス化・標的指向化
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        西川 元也
        Project Closed
        細胞治療;ステルス化;体内動態;酸化ストレス;ターゲティング
      • 遺伝子発現再活性化現象を利用したリピータブルタンパク質発現システムの開発
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        高倉 喜信
        Project Closed
        遺伝子発現;肝臓;転写因子;非ウイルスベクター;物理刺激
      • Design and delivery of plasmid vector for spatiotemporal control of the expression of therapeutic protein and siRNA
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Yoshinobu TAKAKURA
        Project Closed
        ドラッグデリバリー;遺伝子治療;RNA干渉;プラスミドDNA;融合タンパク質;デリバリー
      • DEVELOPMENT OF CANCER CHEMO-IMMUNOTHERAPEUTIC SYSTEM USING REDOX CONTROLLABLE DDS
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Makiya NISHIKAWA
        Project Closed
        ドラッグデリバリー;活性酸素;カタラーゼ;癌転移;高血糖;活性酵素;ハイドロゲル;デイバリー;デリバリー
      • インターフェロン遺伝子発現の増強・持続化による新規癌治療戦略
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        高倉 喜信
        Project Closed
        遺伝子治療;インターフェロン;薬動学解析;ベクター開発;CpGモチーフ
      • 抗原投与を全く必要としない細胞内抗原トラップ型新規腫瘍ワクチンの開発
        Grant-in-Aid for Exploratory Research
        Kyoto University
        高倉 喜信
        Project Closed
        DNAワクチン;熱ショックタンパク質;膜透過ペプチド;抗原提示細胞;細胞内動態
      • Development of all inclusive anti tumor immunotherapy based on engineered protein and nucleic acid
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Yoshinobu TAKAKURA
        Project Closed
        抗原デリバリー;DNA ワクチン;熱ショックタンパク質;抗原提示細胞;CpGモチーフ;DNAワクチン
      • RNAiによる遺伝子ノックダウンと抗原デリバリーを組み合せた新規免疫療法の確立
        Grant-in-Aid for Exploratory Research
        Kyoto University
        高倉 喜信
        Project Closed
        RNA干渉;遺伝子ノックダウン;抗原提示細胞;樹状細胞;shRNA発現ベクター;siRNA発現ベクター;CD80;CD86;T細胞活性化
      • Design and delivery of nucleic acid drugs for optimization of DNA vaccination
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Yoshinobu TAKAKURA
        Project Closed
        DNAワクチン;樹状細胞;プラスミドDNA;デリバリー;細胞障害性T細胞;細胞内動態;CpGモチーフ;Hsp70;プラスミド;抗原提示細胞;MHC class I;エレクトロポレーション, DNA vaccination;Dendritic cell;Plasmid DNA;Delivery;Cytotoxic T cell;Intracellular trafficking;CpG motif;Hsp70
      • In vivo RNAiによる遺伝子ノックダウンマウス作出と薬物動態研究への応用
        Grant-in-Aid for Exploratory Research
        Kyoto University
        高倉 喜信
        Project Closed
        RNA干渉;遺伝子ノックダウン;トランスポーター;P-Glycoprotein;siRNA;siRNA発現ベクター;ハイドロダイナミクス法;in vivo;ルシフェラーゼ;in vitro;p-糖タンパク
      • Establishment of novel delivery strategies to dendritic cells and optimization of DNA vaccination
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Yoshinobu TAKAKURA
        Project Closed
        DNAワクチン;樹状細胞;プラスミドDNA;デリバリー;細胞障害性T細胞;細胞内動態;エレクトロポーレション;皮内投与;DNAキャリアー;局所投与;抗原提示細胞;抗体産生;免疫応答, DNA vaccination;Dendritic cell;Plasmid DNA;Delivery;Cytotoxic T cell;Intracellular trafficking;Electroporation;Intradermal injection
      • プラスミド水溶液投与による高効率遺伝子導入法を利用したがんのサイトカイン療法
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        高倉 喜信
        Project Closed
        ハイドロダイナミクス法;プラスミドDNA;サイトカイン;がん治療;肝臓;マイクロスフェアー
      • プラスミド水溶液投与による高効率遺伝子導入法を利用したがんのサイトカイン療法
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        高倉 喜信
        Project Closed
        遺伝子治療;プラスミドDNA;サイトカイン;インターフェロン;肝転移;マウスモデル
      • Development of plasmid DNA delivery methods to antigen presenting cells for optimized DNA vaccination
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Yoshinobu TAKAKURA
        Project Closed
        DNAワクチン;プラスミドDNA;マクロファージ;樹状細胞;カチオン性キャリアー;局所投与;抗体産生;カチオン性高分子;抗原提示細胞;細胞取り込み;サイトカイン;CpGモチーフ, DNA vaccine;plasmid DNA;macrophage;dendritic cell;cationic carrier;local administration;antibody production
      • Development of local drug disposition analysis and delivery methods in human solid tumors
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Yoshinobu TAKAKURA
        Project Closed
        固形腫瘍;ドラッグデリバリーシステム;局所投与;遺伝子治療;アンチセンスオリゴヌクレオチド;プラスミドDNA;ヒト腫瘍細胞;単離腫瘍灌流実験系, solid tumors;drug delivery system;local administration;gene therapy;antisense oligonucleotide;plasmid DNA
      • 遺伝子医薬品の体内動態および細胞取り込み機構の解明に基づくデリバリー戦略の確立
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Yoshinobu TAKAKURA
        Project Closed
        遺伝子治療;DNAワクチン;プラスミドDNA;マクロファージ;細胞取り込み;スカベンジャー受容体;CpGモチーフ;腫瘍壊死因子;インターロイキン-6;ポリアニオン;活性化, gene therapy;DNA vaccination;plasmid DNA;macrophage;cellular uptake;scavenger receptor;CpG motif;tumor necrosis factor
      • 動態-発現相関の解析に基づくin vivo遺伝子導入キャリアーシステムの分子設計
        Grant-in-Aid for Scientific Research (B).
        KYOTO UNIVERSITY
        Mitsuru HASHIDA
        Project Closed
        遺伝子治療;非ウィルス性ベクター;プラスミドDNA;肝臓ターゲティング;糖修飾リポソーム;糖修飾高分子;膜融合ペプチド;DDS;体内動態;動態発現相関;DNAプラスミド;カチオン性リポソーム;ポリカチオン;コレステロール;カオチン性リポソーム;ガラクトース受容体;エンドサイトーシス, gene therapy;non-viral vectors;plasmid DNA;liver targeting;glycosylated liposomes;glycosylated macromolecules;membrane-fusogenic peptides
      • Development of Gene Delivery Systems to Intestinal Epithelial Cells as a Target
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Yoshinobu TAKAKURA
        Project Closed
        遺伝子導入;消化管上皮細胞;Caco-2細胞;Pam-T細胞;MDCK細胞;LLC-PK_1細胞;インターフェロン;分泌方向性;遺伝子治療;Caco-2;分泌タンパク;カチオン性リポソーム, gene transfer;epithelial cells;Caco-2 cells;Pam-T cells;MDCK cells;LLC-PK_1 cells;interferon;secretion polarity
      • Systematic development of targeting systams for prevention of tissue damages in organ transplantation
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Mitsuru HASHIDA
        Project Closed
        臓器移植;免疫抑制剤;化学修飾;細胞障害;活性酸素;SOD;高分子化プロドラッグ;タクロリムス;細胞傷害;活性酵素;マクロファージ, organ transplantation;immunosuppressant;chemical modification;tissue damage;reactive oxygen species;superoxide disumutase;macromolecular prodrug;tacrolimus
      • Development of Delivery Systems for the Control of Pharmacokinetics and Intracellular Trafficking of Antisense Drugs
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Yoshinobu TAKAKURA
        Project Closed
        アンチセンスDNA;体内動態;細胞内トラフィッキング;ファーマコキネティクス;肝臓;デリバリーシステム;糖鎖認識機構;poly (L-lysine);poly(L-lysine);クリアランス;c-myc;phosphorothioate, Antisense oligonucleotide;In vivo disposition;Intracellular trafficking;Pharmacokinetics;Liver;Dclivery systems;Sugar-recognition system;poly (L-lysine)
      • Establishment of the theory based on a skin diffusion model for the optimal design of a new approach to enhanced trandermal drug delivery
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Mitsuru HASHIDA
        Project Closed
        経皮吸収;経皮治療システム;吸収促進剤;プロドラッグ;皮膚拡散モデル;皮膚透過性;物理化学的特性;acyclovir, percutaneous absorption;transdermal therapeutic;penetration enhancer;prodrug;skin diffusion model;skin permeability;physicochemical properties;acyclovir
      • IFN-γ遺伝子導入による抗腫瘍機構の解析と遺伝子治療へ向けての基礎的研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        渡辺 好彦
        Project Closed
        インターヘェロン-γ;遺伝子導入;細胞ワクチン;遺伝子治療;腫瘍免疫;細胞障害性T細胞;腫瘍抗原
      • 遺伝子治療を目的とした核酸医薬品のデリバリーシステムの確立
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Kyoto University
        高倉 喜信
        Project Closed
        遺伝子治療;デリバリーシステム;プラスミドDNA;アンチセンスDNA;体内動態;リポソーム;スカベンジャーレセプター
      • Establishment of Evaluation Method for Function of Drug Targeting Systems and Systematization of their Physicochemical Character-Function Relationship
        Grant-in-Aid for General Scientific Research (B)
        KYOTO UNIVERSITY
        Mitsuru HASHIDA
        Project Closed
        Drug Delivery System;ターゲティング;高分子運搬体システム;微粒子性運搬体システム;臓器クリアランス;臓器潅流実験系;培養細胞;製剤特性;ドラッグデリバリーシステム, Drug delivery system;Targeting;Macromolecular carrier system;Micropaticulate carrier system;Organ clearance;Organ perfusion experiment;Cultured cells
      • タ-ゲティング型製剤の製剤特性ー機能相関の体系化
        Grant-in-Aid for General Scientific Research (B)
        Kyoto University
        瀬崎 仁
        Project Closed
        タ-ゲティング;臓器潅流実験;細胞培養;微粒子性運搬体;高分子運搬体;モノクロ-ナル抗体;糖鎖認識機構;薬物送達システム
      • Pharmacokinetic modeling and penetration enhancement of the percutaneous drug absorption based on diffusion theory
        Grant-in-Aid for General Scientific Research (C)
        Kyoto University
        Mitsuru HASHIDA
        Project Closed
        経皮吸収;皮膚モデル;拡散理論;高速ラプラス逆変換;吸収促進剤;皮膚透過;脂溶性;in vitro拡散実験, Percutaneous absorption;Skin model;Diffusion theory;Fast inverse Laplace transformation;Absorption enhancer;Skin penetration;Drug lipophilicity;In vitro diffusion experiments
      • Establishment of a new theory for assessment of drug disposition
        Grant-in-Aid for General Scientific Research (C)
        KYOTO UNIVERSITY
        Mitsuru HASHIDA
        Project Closed
        化学療法;組織移行性;臓器灌流実験;単離腫瘍標本;モ-メント解析;脂溶性プロドラッグ;高分子化プロドラッグ;抗体結合体;臓器潅流実験;薬物組織移行性;モーメント解析;抗癌剤;癌病巣モデル;プロドラッグ;ドラッグデリバリーシステム, Chemotherapy;Tissue Transport;Organ Perfusion Experiment;Isolated Tumor Preparation;Moment Analysis;Lipophilic Prodrug;Macromolecular Prodrug;Antibody Conjugate
      • Control of biopharmaceutical properties of peptide drugs by chemical modification employing carbohydrates
        Grant-in-Aid for General Scientific Research (B)
        KYOTO UNIVERSITY
        Hitoshi SEZAKI
        Project Closed
        ペプチド性医薬品;化学修飾;電荷;高分子化修飾;ポリエチレングリコ-ル;デキストラン;レセプタ-仲介エンドサイトシス;ス-パ-オキサイドジスムタ-ゼ;大豆トリプシンインヒビター;ウリカーゼ;体内挙動, Peptide Drug;Chemical Modification;Electric Charge;Macromolecular Modification;Polyethyleneglycol;Dextran;Receptor-mediated Transport;Superoxide Dismutase
      • 薬物の腫瘍移行性評価システムの開発とそれを利用したターゲティング型抗癌剤設計
        Grant-in-Aid for Cancer Research
        Kyoto University
        瀬崎 仁
        Project Closed
        癌化学療法;ターゲティング;抗癌剤;腫瘍移行性;腫癌組織灌流;モーメント解析;プロドラッグ;マイトマイシンC

      External funds: others

      • Study on Cell Specific Drug Delivery
      • Study on Dosage Form Design for Gene Therapy
      • ヒト肝細胞キメラマウスを用いた治療抵抗性の肝炎に関する研究 
        厚生労働科学研究費
        From 2008, To 2010
        分担
      • 創薬と新規治療法に開発に資するヒト肝細胞キメラマウスを用いた肝炎ウィルス制御に関する研究
        厚生労働科学研究費
        From 2011, To 2013
        分担
      list
        Last Updated :2022/07/01

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Laboratory Techniques in Pharmaceutical Sciences
          8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research Training(Biopharmaceutics and Drug Metabolism)
          D147, Year-long, Faculty of Pharmaceutical Sciences, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Practice in Basic Pharmacodynanic Sciences
          4208, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Organic Chemistry for Drug Discovery B
          8204, Fall, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Pharmaceutical Biochemistry
          8103, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research in Pharmaceutical Sciences II
          6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar for Pharmaceutical Sciences I
          6104, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Pharmaceutical Sciences I
          6005, Fall, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Pharmaceutical Sciences
          6002, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Clinical Clerkship in Community Pharmacy
          B902, Year-long, Faculty of Pharmaceutical Sciences, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Pharmaceutical Biochemistry B
          8206, Spring, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Clinical Pharmacy
          B355, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Pharmaceutical Sciences III
          6007, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar in Basic Patho-Functional Analysis
          2308, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pre-Training for Clinical Clerkship
          B354, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research in Basic Pharmacodynanic Sciences
          3208, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Basic Organic Chemistry II
          1210, Fall, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research Training(Biopharmaceutics and Drug Metabolism)
          8147, Year-long, Faculty of Pharmaceutical Sciences, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Pharmacy and Biomedical Sciences for Drug Discovery
          8208, Fall, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Physical Chemistry for Drug Discovery
          1217, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar for Pharmaceutical Sciences II
          6105, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Clinical Clerkship in Hospital Pharmacy
          B901, Year-long, Faculty of Pharmaceutical Sciences, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          Clinical Clerkship in Hospital Pharmacy
          E901, Year-long, Faculty of Pharmaceutical Sciences, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          21COE化学講義3(理)
          8001, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Pharmaceutical Sciences and Ethics
          U129, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          共用試験関係
          B999, Year-long, Faculty of Pharmaceutical Sciences, 0
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research in Pharmaceutical Sciences I
          6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Basic Biological Chemistry II
          1214, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Basic Physical Chemistry I
          1211, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          8105, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          実務実習
          B998, Year-long, Faculty of Pharmaceutical Sciences, 0
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Laboratory Techniques in Pharmaceutical Sciences
          6003, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Drug Discovery & Development II: Lead Discovery Technology
          1111, Fall, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutics II (Pharmacokinetics)
          C312, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar for Pharmaceutical Sciences III
          6106, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Physical Chemistry for Drug Discovery A
          8201, Spring, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Physical Chemistry for Drug Discovery
          8101, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research in Pharmaceutical Sciences III
          6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Basic Pharmacy and Biomedicinal Sciences I
          1215, Fall, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Medicinal Pharmacy 3 (Biopharmaceutics)
          A312, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pre-Training for Clinical Clerkship
          E354, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Pharmaceutical Sciences II
          6006, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Clinical Clerkship in Community Pharmacy
          E902, Year-long, Faculty of Pharmaceutical Sciences, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          1028, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Modern Life Sciences for Drug Discovery
          1027, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Bioinformatics II: Lead Discovery
          1108, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Organic Chemistry for Drug Discovery
          1026, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research Training(Biopharmaceutics and Drug Metabolism)
          B815, Year-long, Faculty of Pharmaceutical Sciences, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          1208, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Organic Chemistry for Drug Discovery
          8102, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From Apr. 2011, To Mar. 2012
          医療実務事前学習
          Year-long, 薬学部
        • From Apr. 2011, To Mar. 2012
          医療薬学III(薬物動態学)
          Fall, 薬学部
        • From Apr. 2011, To Mar. 2012
          特別実習(病態情報薬学)
          Year-long, 薬学部
        • From Apr. 2011, To Mar. 2012
          薬剤学3(薬物動態学)
          Fall, 薬学部
        • From Apr. 2011, To Mar. 2012
          医薬品開発プロジェクト演習I
          Spring, 薬学部
        • From Apr. 2011, To Mar. 2012
          統合型薬学演習
          Fall, 薬学部
        • From Apr. 2011, To Mar. 2012
          特別実習[病態情報薬学]
          Year-long, 薬学部
        • From Apr. 2011, To Mar. 2012
          薬局実務実習
          Year-long, 薬学部
        • From Apr. 2011, To Mar. 2012
          Introduction to Basic Pharmacy and Biomedical Sciences
          Spring, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Research in Biopharmaceutics and Drug Metabolism
          Year-long, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Advanced Methods in Pharmacodynamic Sciences
          Year-long, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Biopharmaceutics and Drug Metabolism Seminar
          Year-long, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Pharmaceuticals and Medicine
          Spring, 全学共通科目
        • From Apr. 2011, To Mar. 2012
          先端医療SGD演習
          Spring, 薬学部
        • From Apr. 2011, To Mar. 2012
          共用試験関係
          Year-long, 薬学部
        • From Apr. 2011, To Mar. 2012
          医療倫理実習
          Fall, 薬学部
        • From Apr. 2011, To Mar. 2012
          地域医療薬学
          Spring, 薬学部
        • From Apr. 2011, To Mar. 2012
          Basic Laboratory Techniques in Pharmacy and
          Spring, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Basic Laboratory Techniques in Pharmacy and
          Fall, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2011, To Mar. 2012
          病院実務実習
          Year-long, 薬学部
        • From Apr. 2011, To Mar. 2012
          臨床薬学総論
          Fall, 薬学部
        • From Apr. 2011, To Mar. 2012
          An Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2012, To Mar. 2013
          Frontier SGD Classes for Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2012, To Mar. 2013
          Laboratory for medical ethics
          Fall, 薬学部
        • From Apr. 2012, To Mar. 2013
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2012, To Mar. 2013
          Medicinal Pharmacy III(Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2012, To Mar. 2013
          Pharmaceutical R&D Exercise I
          Spring, 薬学部
        • From Apr. 2012, To Mar. 2013
          doctoral program
          Spring, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          doctoral program
          Fall, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Community Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2012, To Mar. 2013
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Introduction to Basic Pharmacy and Biomedical Sciences
          Spring, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Advanced Basic Pharmacy and Biomedicinal Sciences I
          Fall, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2012, To Mar. 2013
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2012, To Mar. 2013
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2012, To Mar. 2013
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2012, To Mar. 2013
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2012, To Mar. 2013
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2012, To Mar. 2013
          An Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2012, To Mar. 2013
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2012, To Mar. 2013
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2013, To Mar. 2014
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2013, To Mar. 2014
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2013, To Mar. 2014
          Pharmaceutical R&D Exercise I
          Spring, 薬学部
        • From Apr. 2013, To Mar. 2014
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2013, To Mar. 2014
          Laboratory for medical ethics
          Fall, 薬学部
        • From Apr. 2013, To Mar. 2014
          Frontier SGD Classes for Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2013, To Mar. 2014
          Community Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2013, To Mar. 2014
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2013, To Mar. 2014
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2013, To Mar. 2014
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2013, To Mar. 2014
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2013, To Mar. 2014
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2013, To Mar. 2014
          Introduction to Basic Pharmacy and Biomedical Sciences
          Spring, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          doctoral program
          Spring, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          doctoral program
          Fall, 薬学研究科
        • From Apr. 2013, To Mar. 2014
          An Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2013, To Mar. 2014
          Pharmaceuticals and Medicine
          Spring, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2014, To Mar. 2015
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2014, To Mar. 2015
          Pharmaceutical R&D Exercise I
          Spring, 薬学部
        • From Apr. 2014, To Mar. 2015
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2014, To Mar. 2015
          Laboratory for medical ethics
          Fall, 薬学部
        • From Apr. 2014, To Mar. 2015
          Frontier SGD Classes for Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2014, To Mar. 2015
          Community Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2014, To Mar. 2015
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2014, To Mar. 2015
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2014, To Mar. 2015
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2014, To Mar. 2015
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2014, To Mar. 2015
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2014, To Mar. 2015
          Biopharmaceutics
          Fall, 医学研究科
        • From Apr. 2014, To Mar. 2015
          Introduction to Basic Pharmacy and Biomedical Sciences
          Spring, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Basic Pharmacy and Biomedicinal Sciences I
          Fall, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2014, To Mar. 2015
          Biopharmaceutics
          Fall, 工学研究科
        • From Apr. 2014, To Mar. 2015
          An Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Laboratory for medical ethics
          Fall, 薬学部
        • From Apr. 2015, To Mar. 2016
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2015, To Mar. 2016
          Pharmaceutical R&D Exercise I
          Spring, 薬学部
        • From Apr. 2015, To Mar. 2016
          Community Clinical Pharmacy
          Spring, 薬学部
        • From Apr. 2015, To Mar. 2016
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Introduction to Basic Pharmacy and Biomedical Sciences
          Spring, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2015, To Mar. 2016
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2015, To Mar. 2016
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2015, To Mar. 2016
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2015, To Mar. 2016
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2015, To Mar. 2016
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2015, To Mar. 2016
          An Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2015, To Mar. 2016
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2015, To Mar. 2016
          Biopharmaceutics
          Fall, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Biopharmaceutics
          Fall, 医学研究科
        • From Apr. 2016, To Mar. 2017
          ILAS Seminar
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2016, To Mar. 2017
          Pharmaceutical R&D Exercise I
          Spring, 薬学部
        • From Apr. 2016, To Mar. 2017
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Introduction to Basic Pharmacy and Biomedical Sciences
          Spring, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Basic Pharmacy and Biomedicinal Sciences I
          Fall, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2016, To Mar. 2017
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2016, To Mar. 2017
          Research Training(Clinical Pharmacy and Education)
          Year-long, 薬学部
        • From Apr. 2016, To Mar. 2017
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2016, To Mar. 2017
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2016, To Mar. 2017
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2016, To Mar. 2017
          Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2016, To Mar. 2017
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2016, To Mar. 2017
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2016, To Mar. 2017
          Biopharmaceutics
          Fall, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Biopharmaceutics
          Fall, 医学研究科
        • From Apr. 2017, To Mar. 2018
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2017, To Mar. 2018
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2017, To Mar. 2018
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2017, To Mar. 2018
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2017, To Mar. 2018
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2017, To Mar. 2018
          Interdisciplinary Sciences
          Fall, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Introduction to Clinical Pharmacy
          Spring, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2017, To Mar. 2018
          Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2017, To Mar. 2018
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2017, To Mar. 2018
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2017, To Mar. 2018
          Biopharmaceutics
          Fall, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Biopharmaceutics (LIMS)
          Fall, 医学研究科
        • From Apr. 2018, To Mar. 2019
          共用試験関係
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Drug Discovery & Development II: Lead Discovery Technology
          Fall, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Bioinformatics II: Lead Discovery
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Introduction to Organic Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Introduction to Physical Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Introduction to Modern Life Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Pre-Training for Clinical Clerkship
          Fall, 薬学部
        • From Apr. 2018, To Mar. 2019
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Basic Pharmacy and Biomedicinal Sciences I
          Fall, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Basic Organic Chemistry II
          Fall, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Basic Physical Chemistry I
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Basic Biological Chemistry II
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          実務実習
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2018, To Mar. 2019
          Interdisciplinary Sciences
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Introduction to Clinical Pharmacy
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2018, To Mar. 2019
          Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2018, To Mar. 2019
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Fall, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2018, To Mar. 2019
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Biopharmaceutics
          Fall, 工学研究科
        • From Apr. 2018, To Mar. 2019
          Biopharmaceutics (LIMS)
          Fall, 医学研究科
        • From Apr. 2019, To Mar. 2020
          共用試験関係
          Year-long, 薬学部
        • From Apr. 2019, To Mar. 2020
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Organic Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Physical Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Modern Life Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Pre-Training for Clinical Clerkship
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Basic Pharmacy and Biomedicinal Sciences II
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Basic Organic Chemistry I
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Basic Physical Chemistry II
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Basic Biological Chemistry I
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          実務実習
          Year-long, 薬学部
        • From Apr. 2019, To Mar. 2020
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2019, To Mar. 2020
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2019, To Mar. 2020
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2019, To Mar. 2020
          Integrated Pharmaceutical Exercise
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Interdisciplinary Sciences
          Fall, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Introduction to Clinical Pharmacy
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Drug Discovery & Development III: Clinical Development Process
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Pharmaceutics II (Pharmacokinetics)
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Medicinal Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Research in Pharmaceutical Sciences III
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Research in Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar for Pharmaceutical Sciences III
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar for Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Pharmaceutical Sciences III
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2019, To Mar. 2020
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2019, To Mar. 2020
          Biopharmaceutics (LIMS)
          Fall, 医学研究科
        • From Apr. 2020, To Mar. 2021
          Pharmaceutical Common Achievement Tests
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Drug Discovery & Development II: Lead Discovery Technology
          Fall, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Bioinformatics II: Lead Discovery
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Introduction to Organic Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Introduction to Physical Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Introduction to Modern Life Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Pre-Training for Clinical Clerkship
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Basic Pharmacy and Biomedicinal Sciences I
          Fall, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Basic Organic Chemistry II
          Fall, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Basic Physical Chemistry I
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Basic Biological Chemistry II
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          実務実習(病3薬2)
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          実務実習(病2薬1)
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          実務実習(病4薬3)
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          Interdisciplinary Sciences :Life and Society (Collaboration of Technology, Ethics for Sustainable and Healthy Society)
          Fall, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Introduction to Clinical Pharmacy
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Pharmaceutics II (Pharmacokinetics)
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Research in Pharmaceutical Sciences III
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Research in Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar for Pharmaceutical Sciences III
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar for Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Pharmaceutical Sciences III
          Spring, 薬学研究科
        • From Apr. 2020, To Mar. 2021
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2020, To Mar. 2021
          Biopharmaceutics (LIMS)
          Fall, 医学研究科
        • From Apr. 2021, To Mar. 2022
          Pharmaceutical Common Achievement Tests
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Introduction to Pharmacy and Biomedical Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Introduction to Organic Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Introduction to Physical Chemistry for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Introduction to Modern Life Sciences for Drug Discovery
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Pre-Training for Clinical Clerkship
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Pre-Training for Clinical Clerkship
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences
          Fall, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Basic Organic Chemistry I
          Fall, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Basic Physical Chemistry II
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Basic Biological Chemistry I
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Laboratory Practice in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Research in Basic Pharmacodynanic Sciences
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar in Basic Patho-Functional Analysis
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          実務実習(薬2病3)
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          実務実習(薬1病2)
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          実務実習(薬3病4)
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Research Training(Biopharmaceutics and Drug Metabolism)
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Clinical Clerkship in Hospital Pharmacy
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Interdisciplinary Sciences :Life and Society (Collaboration of Technology, Ethics for Sustainable and Healthy Society)
          Fall, 全学共通科目
        • From Apr. 2021, To Mar. 2022
          Introduction to Clinical Pharmacy
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Introduction to Pharmaceutical Sciences and Ethics
          Spring, 全学共通科目
        • From Apr. 2021, To Mar. 2022
          Pharmaceutics II (Pharmacokinetics)
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Pharmacy 3 (Biopharmaceutics)
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Basic Laboratory Techniques in Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Research in Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Research in Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Research in Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Introduction to Pharmaceutical Sciences
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar for Pharmaceutical Sciences III
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar for Pharmaceutical Sciences II
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar for Pharmaceutical Sciences I
          Year-long, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Pharmaceutical Sciences I
          Fall, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Pharmaceutical Sciences II
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Pharmaceutical Sciences III
          Spring, 薬学研究科
        • From Apr. 2021, To Mar. 2022
          Clinical Clerkship in Community Pharmacy
          Year-long, 薬学部
        • From Apr. 2021, To Mar. 2022
          Biopharmaceutics (LIMS)
          Fall, 医学研究科

        Participation in PhD Defense

        • Sedative activities of essential oils from Beninese medicinal plants via inhalation administration and structure-activity relationships of their active compounds
          DOUGNON GODFRIED TCHETONNOUGBO, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner
          23 Mar. 2022
        • 脳タンパク質凝集体を標的とした核医学分子イメージングプローブの開発に関する研究
          KAIDE SHO, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner
          23 Mar. 2022
        • Development of immunotherapy using antigen-loaded multifunctional small extracellular vesicles (抗原搭載多機能性細胞外小胞を利用した免疫療法の開発に関する研究)
          LIU WEN, Graduate School of Pharmaceutical Sciences, Chief Examiner
          23 Mar. 2022
        • Rolling circle amplification(RCA)法により調製される長鎖一本鎖DNA(lss-DNA)を利用した核酸構造体のドラッグデリバリーシステムへの応用に関する研究
          ITO KOICHI, Graduate School of Pharmaceutical Sciences, Chief Examiner
          23 Mar. 2022
        • Implementation of highly sensitive small extracellular vesicle (sEV) quantification method in the identification of novel sEV production modulators and the evaluation of sEV pharmacokinetics
          YAMAMOTO AKI, Graduate School of Pharmaceutical Sciences, Chief Examiner
          24 Sep. 2021
        list
          Last Updated :2022/07/01

          Administration

          School management (title, position)

          • From 01 Apr. 2022, To 30 Sep. 2022
            全学情報セキュリティ委員会 委員
          • From 01 Apr. 2022, To 30 Sep. 2022
            人権委員会 委員
          • From 01 Apr. 2022
            学生総合支援機構運営委員会 委員長
          • From 01 Apr. 2022
            学生生活委員会 委員
          • From 01 Apr. 2022, To 30 Sep. 2022
            学生総合支援機構 機構長
          • From 01 Apr. 2010, To 31 Mar. 2011
            京都大学教務事務電算管理運営委員会 委員
          • From 01 Apr. 2010
            大学評価委員会 点検・評価実行委員会 委員
          • From 01 Apr. 2008, To 31 Mar. 2011
            教養教育専門委員会 委員
          • From 01 Apr. 2010, To 31 Mar. 2012
            教育研究評議会評議員
          • From 01 Apr. 2011, To 31 Mar. 2012
            京都大学教務事務電算管理運営委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2012
            大学評価委員会点検・評価実行委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2012
            教職教育委員会/教職科目連絡小委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            評議員
          • From 31 Jan. 2012, To 30 Jan. 2014
            教職教育委員会 委員
          • From 01 Apr. 2012, To 31 Mar. 2013
            京都大学教職教育委員会教職科目連絡小委員会 委員
          • From 01 Apr. 2012, To 31 Mar. 2013
            大学評価委員会 点検・評価実行委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2015
            人権委員会 委員
          • From 01 Apr. 2010, To 31 Mar. 2014
            評議員
          • From 01 Apr. 2014, To 30 Sep. 2014
            京都大学財務委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            全学情報セキュリティ委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            博士課程教育リーディングプログラム運営会議 委員
          • From 05 Feb. 2014, To 31 Mar. 2016
            吉田寮整備委員会委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            吉田寮業務実施委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            国際高等教育院教養・共通教育協議会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            大学評価委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            教育研究評議会 評議員
          • From 01 Apr. 2014, To 31 Mar. 2016
            産官学連携本部運営協議会協議員 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            研究科長部会
          • From 01 Apr. 2010, To 31 Mar. 2011
            薬学研究科附属統合薬学教育開発センター長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬学研究科 研究科長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬学部 学部長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬用植物園長
          • From 01 Apr. 2014, To 31 Mar. 2016
            部局長会議
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬学研究科附属統合薬学教育開発センター長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬学研究科 研究科長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬学部 学部長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬用植物園長
          • From 01 Apr. 2014, To 31 Mar. 2016
            研究科長部会
          • From 01 Apr. 2014, To 31 Mar. 2016
            部局長会議
          • From 01 Apr. 2014, To 09 Sep. 2015
            京都大学産学共同実用化促進事業実施委員会 3号委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            産官学連携本部運営協議会 5号協議員
          • From 01 Apr. 2014
            原子力研究整備委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            入学試験委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            京都大学博士課程教育リーディングプログラム運営会議 委員
          • From 01 Aug. 2014, To 28 Feb. 2015
            京都大学研究公正の推進検討委員会 委員
          • From 01 Sep. 2014, To 31 Aug. 2016
            京都大学医学研究利益相反マネジメント委員会 2号委員
          • From 27 Sep. 2014, To 28 Feb. 2015
            京都大学研究公正の推進検討委員会 研究不正対応小委員会 委員長
          • From 01 Oct. 2014, To 30 Sep. 2016
            財務委員会 委員
          • From 01 Mar. 2015
            京都大学研究公正委員会 委員
          • From 01 Apr. 2015, To 31 Mar. 2016
            総長選考会議 委員 委員
          • From 01 Apr. 2015
            全学情報セキュリティ委員会 委員
          • From 01 May 2015, To 31 Mar. 2016
            教育活動評価委員会 委員
          • From 01 Apr. 2015, To 31 Mar. 2016
            人事制度検討会 委員
          • From 01 May 2015, To 31 Mar. 2016
            教員活動評価委員会 委員
          • From 01 Apr. 2016
            大学評価委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2018
            教育制度委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2017
            教育制度委員会WG1 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            原子力研究整備委員会 委員
          • From 01 Mar. 2015, To 31 Mar. 2016
            京都大学研究公正委員会 委員
          • From 01 Feb. 2018, To 30 Sep. 2018
            京都大学動物実験委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2020
            学生生活委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2020
            学生生活委員会第三小委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2019
            障害者入試委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2019
            大学評価委員会 委員
          • To 31 Mar. 2020
            学生表彰選考委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2020
            学生生活委員会第三小委員会 委員長
          • From 01 Oct. 2020, To 30 Sep. 2022
            副学長
          • From 01 Oct. 2020
            教育制度委員会教育質保証専門委員会 副委員長
          • From 01 Oct. 2020, To 30 Sep. 2022
            部局長会議
          • From 01 Oct. 2020, To 30 Sep. 2022
            研究科長部会

          Faculty management (title, position)

          • From 01 Apr. 2011, To 31 Mar. 2012
            教務委員長
          • From 01 Apr. 2011, To 31 Mar. 2020
            国際交流委員会 委員
          • From 01 Apr. 2009, To 31 Mar. 2014
            将来計画委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2012
            エネルギー管理委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2020
            自己評価等調査検討委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2014
            寄附講座検討委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2014
            寄附講座「医薬産業政策学講座」運営委員
          • From 01 Apr. 2010, To 31 Mar. 2014
            統合薬学教育開発センター運営委員会 委員
          • From 01 Apr. 2010, To 31 Mar. 2014
            実務実習委員会 委員長
          • From 01 Apr. 2012, To 31 Mar. 2013
            安全環境委員長
          • From 01 Apr. 2012, To 31 Mar. 2014
            ハラスメント相談窓口
          • From 01 Apr. 2014, To 31 Mar. 2016
            将来計画委員会 委員長
          • From 01 Apr. 2013, To 31 Mar. 2020
            予算委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            元素分析研究施設・質量分析室運営委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            超伝導NMRスペクトロメーター室運営管理委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2020
            エネルギー管理委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2016
            人権委員会 委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            統合薬学教育開発センター運営委員会 委員長
          • From 01 Apr. 2014, To 31 Mar. 2016
            寄附講座検討委員会 委員長
          • From 01 Apr. 2014, To 31 Mar. 2016
            寄附講座「ナノバイオ医薬創成科学講座」運営委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            兼業審査・利益相反審査委員会 委員長
          • From 01 Apr. 2014, To 31 Mar. 2016
            薬用植物園管理委員会 委員長
          • From 01 Apr. 2014, To 31 Mar. 2021
            国際交流委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2012
            学生便覧編集委員
          • From 01 Apr. 2012, To 31 Mar. 2014
            環境・安全衛生委員会 委員長
          • From 01 Apr. 2012, To 31 Mar. 2014
            教務委員会 副委員長
          • From 01 Apr. 2009, To 31 Mar. 2012
            薬学研究科薬学専攻長
          • From 01 Apr. 2016, To 31 Mar. 2018
            薬学研究科 薬学専攻長
          • From 01 Apr. 2016, To 31 Mar. 2018
            薬学科 学科長
          • From 01 Apr. 2016, To 31 Mar. 2020
            将来計画委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2020
            実務実習委員会 委員長
          • From 01 Apr. 2016, To 31 Mar. 2018
            教務委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2020
            薬用植物園管理委員会 委員
          • From 01 Apr. 2018, To 31 Mar. 2021
            動物実験委員会委員長
          • From 01 Apr. 2010, To 31 Mar. 2014
            自己評価等調査検討委員会 委員長
          • From 01 Apr. 2021, To 31 Mar. 2022
            人権委員会 委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            ハラスメント相談窓口
          • From 01 Apr. 2016, To 31 Mar. 2022
            統合薬学教育開発センター運営委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2020
            寄附講座検討委員会 委員
          • From 01 Apr. 2017, To 31 Mar. 2021
            寄附講座「ナノバイオ医薬創成科学講座」運営委員
          • From 01 Apr. 2017, To 31 Mar. 2018
            図書委員会 委員
          list
            Last Updated :2022/07/01

            Academic, Social Contribution

            Committee Memberships

            • From 2000
              評議員, 日本薬剤学会
            • From 1999
              幹事、評議員, 日本DDS学会
            • From 1998
              評議員, 日本薬物動態学会

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