Basic Information

Affiliated programs (koza)

• Graduate School of Engineering, マイクロエンジニアリング専攻 バイオメカニクス分野, 講師
• Graduate School of Medicine, 医学専攻 バイオメカニクス研究領域, 講師
• Graduate School of Medicine, 医科学専攻 バイオメカニクス研究領域, 講師

Faculty

• 国際高等教育院

Professional Memberships

• 日本機械学会
• CHEMINAS
• International Conference on Miniaturized Systems for Chemistry and Life Sciences (Social Committee Member, MicroTAS 2021, online)
• Tissue Engineering and Regenerative Medicine International Society (TERMIS)
• Africa International Biotechnology and Biomedical Conference, AIBBC (Founding member, Chief organizer)

Academic Degree

• Masters Degree in Engineering(Kyoto University)
• PhD (Engineering)(Kyoto University)

Profile

• Profile

  My research focuses on design and function manipulation of multicellular systems using engineering tools. The aims are to 1) clarify the role of mechanical factors in the realization and control of biological functions at both the cellular and tissue level, and 2) to harness engineering techniques to create functional tissues and biologics for regenerative medicine, drug development, etc. Different tools have been developed and are being employed toward achieving these aims. Remarkably, an original micromesh culture approach, dubed the "shoji" technique, has been developed to modulate the cell adhesion microspace, enabling not only the induction of self-organization of multicellular systems including cell sheets, but also function manipulation of the same. 

  
  

  Ongoing and past projects include:

  
  

  1) Mechanobiology of stem cell self-organization and differentiation, which focuses on understanding how engineering the stem cell adhesion microenvironment determines stem cell tissue formation and fate decision.

  
  

  2) Biofabrication of cell sheets with controlled cell alignment for regenerative medicine applications.

  
  

  3) Development of blood brain barrier (BBB) model recapitulating the in vivo architecuture and multicellular interactions using self-organized endothelial cell sheets realized by the "shoji" technique.

  
  

  4) On-chip high-yield single cell fusion technique employing electric field concentration for single-cell surgery and function manipulation toward immunoengineering and regerative medicine applications.  

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201601012599339703

researchmap URL

• https://researchmap.jp/smile

Research

Research Topics, Overview of the research

• Research Topics

  Cellular and Tissue Biomechanics

• Overview of the research

  Research is centered on the integration of engineering and biology to study biomechanics of tissues and cells. Specifically, we are utilizing microfabricated tools and devices to explore the mechanical behaviors of cells and tissues. One key technology developed is the "micro-mesh culture technique", which we are deploying in a number of studies including, long-term stem cell culture and maintenance, investigation of stem cell differentiation in a micro-mechanical environment, cell sheet fabrication, among others. We are also developing organ-on-a-chip models for drug screening, disease modeling and basic biological studies. Our ultimate goal is to contribute to the development and practical application of regenerative medicine for the benefit of the society. Please feel free to make contact if you are interested in collaboration or to be part of the team.

Research Interests

• Biomechanics of Multicellular Systems
• Tissue Engineering
• Microfluidics
• Biofabrication
• Microfabrication
• Biomedical Engineering

Research Areas

• Life sciences, Biomaterials, Biomechanics
• Life sciences, Biomedical engineering, Biomechanics
• Manufacturing technology (mechanical, electrical/electronic, chemical engineering), Applied biofunctional and bioprocess engineering, organoids
• Nanotechnology/Materials, Nano/micro-systems, Microfabrication

Papers

• Study of transmembrane ion transport under tonicity imbalance using a combination of low frequency-electrical impedance spectroscopy (LF-EIS) and improved ion transport model

  S.Li; D.Kawashima; M.Sugawara; H.Obara; K.O.Okeyo; M.Takei

  Biomedical Physics & Engineering Express, Mar. 2022, Peer-reviewed

  
• Pluripotency state of mouse ES cells determines their contribution to self-organized layer formation by mesh closure on microstructured adhesion-limiting substrates

  Yuta Ando; Kennedy Omondi Okeyo; Taiji Adachi

  Biochemical and Biophysical Research Communications, Jan. 2022, Peer-reviewed

  
• Controlling macroscale cell alignment in self-organized cell sheets by tuning the microstructure of adhesion-limiting micromesh scaffolds

  Kennedy O. Okeyo; Yoshikiyo Kibe; Taiji Adachi

  Materials Today Advances, Dec. 2021

  
• Edge-localized alteration in pluripotency state of mouse ES cells forming topography-confined layers on designed mesh substrates

  Yuta Ando; Kennedy Omondi Okeyo; Junko Sunaga; Taiji Adachi

  Stem Cell Research, May 2021, Peer-reviewed

  
• Quantitative early malaria-infected red blood cell detection method based on 3D multi-shell dielectric model

  Anh Kiet TRAN; Daisuke Kawashima; Kenji Hikosaka; Kennedy O. Okeyo; Masahiro Takei

  Chemistry and Micro-Nano Systems, Dec. 2020

  
• Development of a noise elimination electrical impedance spectroscopy (neEIS) system for single cell identification

  A. Kiet Tran; Daisuke Kawashima; Michiko Sugarawa; Hiromichi Obara; Kennedy Omondi Okeyo; Masahiro Takei

  Sensing and Bio-Sensing Research, Dec. 2020, Peer-reviewed

  
• Nuclear transplantation between allogeneic cells through topological reconnection of plasma membrane in a microfluidic system

  Masahiro Okanojo; Kennedy O. Okeyo; Hiroko Hanzawa; Osamu Kurosawa; Hidehiro Oana; Shizu Takeda; Masao Washizu

  Biomicrofluidics, Jun. 2019, Peer-reviewed

  
• Modulation of adhesion microenvironment using mesh substrates triggers self-organization and primordial germ cell-like differentiation in mouse ES cells

  Yuta Ando; Kennedy Omondi Okeyo; Taiji Adachi

  APL BIOENGINEERING, Mar. 2019, Peer-reviewed

  
• A microfluidic device for isolating intact chromosomes from single mammalian cells and probing their folding stability by controlling solution conditions.

  Takahashi T; Okeyo KO; Ueda J; Yamagata K; Washizu M; Oana H

  Scientific reports, Sep. 2018, Peer-reviewed

  
• Self-organization of human iPS cells into trophectoderm mimicking cysts induced by adhesion restriction using microstructured mesh scaffolds

  Kennedy O. Okeyo; Maiko Tanabe; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  Development, Growth & Differentiation, Apr. 2018, Peer-reviewed

  
• Nucleosomes Exhibit Non-uniform Unwrapping Along Native Chromatin Fibers with Increasing Salt Concentration as Revealed by Direct Imaging in a Microfluidic Channel

  Hiroki Mori; Kennedy O. Okeyo; Masao Washizu; Hidehiro Oana

  Biotechnology Journal, Jan. 2018, Peer-reviewed

  
• Toward fabrication of vascularized tissues using a bilayer co-culture approach achieved by a mesh culture technique

  Kai Yamada; Kennedy O. Okeyo; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems, 26 Jul. 2017, Peer-reviewed

  
• Minimization of cell-substrate interaction using suspended microstructured meshes initiates cell sheet formation by self-assembly organization

  Kennedy Omondi Okeyo; Osamu Kurosawa; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  Biomedical Physics and Engineering Express, 19 Dec. 2016, Peer-reviewed

  
• Adhesion patterning by a novel air-lock technique enables localization and in-situ real-time imaging of reprogramming events in one-to-one electrofused hybrids

  S. Sakamoto; K. O. Okeyo; S. Yamazaki; O. Kurosawa; H. Oana; H. Kotera; M. Washizu

  BIOMICROFLUIDICS, Sep. 2016, Peer-reviewed

  
• Cell adhesion control using microstructured meshes induces self-assembly-mediated organoid formation by human iPS cells

  Kennedy O. Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015, 21 Mar. 2016, Peer-reviewed

  
• Live imaging of somatic nuclear reprogramming using an electrofusion microfluidic device with air-lock patterned adhesion areas for fusant localization

  Sakamoto S; Okeyo K.O; Kurosawa O; Oana H; Washizu M

  20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, 2016, Peer-reviewed

  
• Direct acquisition of genome-wide epigenetic information along intact chromatin fibers of individual chromosomes isolated from single mammalian cells

  Takahashi T; Okeyo K.O; Washizu M; Ueda J; Oana H

  20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, 2016, Peer-reviewed

  
• Fabrication of freely standing oriented myotubes using a novel mesh culture method and analysis of calcium dynamics for functionality assay

  Okeyo K.O; Azeyanagi M; Kurosawa O; Oana H; Washizu M

  20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, 2016, Peer-reviewed

  
• Cell Adhesion Minimization by a Novel Mesh Culture Method Mechanically Directs Trophoblast Differentiation and Self-Assembly Organization of Human Pluripotent Stem Cells

  Kennedy Omondi Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Hiromitsu Nakauchi; Masao Washizu

  TISSUE ENGINEERING PART C-METHODS, Oct. 2015, Peer-reviewed

  
• Cell adhesion control by a novel mesh culture method directs differentiation and self-assembly of human ips cells into trophoblasts: Toward organ-on-chip embryogenesis

  Okeyo K.O; Kurosawa O; Yamazaki S; Oana H; Kotera H; Washizu M

  MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2015, Peer-reviewed

  
• Mapping positional distribution of higher-order structures along unfragmented native chromatin fibers isolated from single cells in a microchannel

  Mori H; Okeyo K.O; Washizu M; Oana H

  MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2015, Peer-reviewed

  
• Cytoplasmic transfer without nuclei mixing between dendritic cells and tumor cells achieved by one-to-one electrofusion via micro-orifices in a microfluidic device

  Itagaki Y; Okeyo K.O; Kurosawa O; Oana H; Narita M; Kotera H; Washizu M

  18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 2014, Peer-reviewed

  
• Generation of epithelial cell sheets with defined cell orientation using microstructured mesh sheets as substrates for cell culture

  Okeyo K.O; Yanaru R; Kurosawa O; Oana H; Kotera H; Washizu M

  18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 2014, Peer-reviewed

  
• Stable and long term culture of stem cells under shear flow on a microstructured mesh sheet embedded in a fluidic chamber

  Okeyo K.O; Isozaki T; Kurosawa O; Oana H; Kotera H; Washizu M

  18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 2014, Peer-reviewed

  
• Narrowing slit device for high yield one-to-one electrofusion and culture of fusants without gene mixing

  S. Sakamoto; K. O. Okeyo; O. Kurosawa; H. Oana; H. Kotera; M. Washizu

  2014 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS), 2014, Peer-reviewed

  
• Control of Cell Orientation in Mesenchymal Cell Sheets Fabricated Using Microstructured Mesh Sheet

  Rina Yanaru; Kennedy Omondi Okeyo; Osamu Kurosawa; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  2014 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS), 2014, Peer-reviewed

  
• Cell adhesion control initiate cell sheet formation in a medium suspension

  Okeyo K.O; Omasa N; Kurosawa O; Oana H; Kotera H; Washizu M

  17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 2013, Peer-reviewed

  
• On-chip electroporation device for direct introduction of plasmids into cell nucleus and observation of cell reprogramming process

  Okeyo K.O; Hayashi Y; Kurosawa O; Oana H; Kotera H; Washizu M

  17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 2013, Peer-reviewed

  
• Effect of Actomyosin Contractility on Lamellipodial Protrusion Dynamics on a Micropatterned Substrate

  Kennedy Omondi Okeyo; Masuzo Nagasaki; Junko Sunaga; Masaki Hojo; Hidetoshi Kotera; Taiji Adachi

  CELLULAR AND MOLECULAR BIOENGINEERING, Sep. 2011, Peer-reviewed

  
• Mechanical regulation of actin network dynamics in migrating cells

  Kennedy Omondi Okeyo; Taiji Adachi; Masaki Hojo

  Journal of Biomechanical Science and Engineering, 2010, Peer-reviewed

  
• Dynamic coupling between actin network flow and turnover revealed by flow mapping in the lamella of crawling fragments

  Kennedy Omondi Okeyo; Taiji Adachi; Masaki Hojo

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2009, Peer-reviewed

  
• Actomyosin contractility spatiotemporally regulates actin network dynamics in migrating cells

  Kennedy Omondi Okeyo; Taiji Adachi; Junko Sunaga; Masaki Hojo

  JOURNAL OF BIOMECHANICS, Nov. 2009, Peer-reviewed

  
• Strain field in actin filament network in lamellipodia of migrating cells: Implication for network reorganization

  Taiji Adachi; Kennedy Omondi Okeyo; Yoshimichi Shitagawa; Masaki Hojo

  JOURNAL OF BIOMECHANICS, Feb. 2009, Peer-reviewed

  

Misc.

• MODULATING THE CELL ADHESION MICROENVIRONMENT TO MECHANICALLY DRIVE TROPHECTODERM-LIKE ORGANOID FORMATION FROM HUMAN iPS CELLS

  K. O. Okeyo; O. Kurosawa; H. Oana; M. Washizu

  23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), Oct. 2019

  
• マイクロ流体デバイスを用いたがん細胞から樹状細胞への細胞質移植およびレシピエント細胞の経時観察

  小穴英廣; 飛矢地龍太; オケヨ ケネディ; 成田美和子; 鷲津正夫

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  
• 異種細胞間細胞質移植・経時観察マイクロ流体デバイスの開発

  小穴英廣; 飛矢地龍太; オケヨ ケネディ; 成田美和子; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2019

  
• Reconstituting a Bilayer Cellular System Using an Artificial Matrigel Basement Membrane Achieved by the Micromesh Technique

  Kennedy O. Okeyo; Kai Yamada; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  2018 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2018, Dec. 2018

  
• RECONSTITUTION OF AN EPITHELIAL-ENDOTHELIAL BILAYER BY THE MICROMESH CULTURE TECHNIQUE EMPLOYING AN ARTIFICIAL MATRIGEL BASEMENT MEMBRANE

  Kennedy O. Okeyo; Kai Yamada; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018), Nov. 2018

  
• NUCLEAR TRANSPLANTATION BETWEEN ALLOGENEIC CELLS ACHIEVED BY FUSION-BASED TOPOLOGICAL RECONNECTION OF THE PLASMA MEMBRANE IN A MICROFLUIDIC SYSTEM

  Masahiro Okanojo; Kennedy O. Okeyo; Hiroko Hanzawa; Osamu Kurosawa; Hidehiro Oana; Shizu Takeda; Masao Washizu

  22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018), Nov. 2018

  
• Direct acquisition of individual target chromosomes isolated from single mammalian cells in a microfluidic channel for single cell/chromosome epigenetic analyses

  Hidehiro Oana; Tomohiro Takahashi; Kennedy O. Okeyo; Hiroshi Ochiai; Masao Washizu

  SELECTBIO Single Cell Analysis Summit 2018, Oct. 2018

  
• Direct Observation-based Analysis of Compaction Stability of Individual Chromosomes Isolated from Single Mammalian Cells

  Hidehiro Oana; Tomohiro Takahashi; Kennedy O. Okeyo; Jun Ueda; Masao Washizu

  21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Oct. 2017

  
• 細胞接着制限環境下におけるmES細胞の培養

  安藤悠太; オケヨ ケネディ; 安達泰治

  日本バイオレオロジー学会誌(Web), 2017

  
• マイクロ流体デバイスを用いた1細胞由来の染色体単離・ソーティング技術の開発

  八尋啓; ケネディ オケヨ; 鷲津正夫; 小穴英廣

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2017

  
• 1細胞・染色体単離技術に基づいた細胞の分化度と染色体構造安定性との相関の解析

  高橋智博; ケネディ オケヨ; 上田潤; 鷲津正夫; 小穴英廣

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2017

  
• マイクロ流体デバイスを用いた動物細胞染色体の凝縮構造安定性の解析

  高橋智博; ケネディ オケヨ; 鷲津正夫; 小穴英廣

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2016

  
• 動物細胞クロマチンファイバーに対する化学修飾および凝縮部の光マッピング

  高橋智博; オケヨ ケネディ; 鷲津正夫; 上田潤; 小穴英廣

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2016

  
• 電界集中型細胞融合法を用いたハイブリドーマの作製とその経時観察

  大西樹; オケヨ ケネディ; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2016

  
• 異種細胞間相互作用が可能な二層細胞構造の構築と生体機能計測への応用

  山田快; オケヨ ケネディ; 黒澤修; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2016

  
• 21pm3-PM011 Micro-structured Mesh Sheets for Cell Culture and Cell Sheet Generation

  Okeyo Kennedy Omondi; Yanaru Rina; Kurosawa Osamu; Oana Hidehiro; Washizu Masao

  マイクロ・ナノ工学シンポジウム, 20 Oct. 2014

  
• 21am2-E6 Development of the on-chip control technique of higher-order structure of chromatin

  Mori Hiroki; Oana Hidehiro; Okeyo Kennedy Omondi; Washizu Masao

  マイクロ・ナノ工学シンポジウム, 20 Oct. 2014

  
• 21am2-E4 Microfluidic device for one-to-one electrofusion and selective transfer of cytoplasmic contents from cancer cells to dendritic cells

  Itagaki Yutaro; Okeyo Kennedy Omondi; Kurosawa Osamu; Narita Miwako; Oana Hidehiro; Washizu Masao

  マイクロ・ナノ工学シンポジウム, 20 Oct. 2014

  
• 1E31 Cell Sheet Formation Utilizing Cell Adhesion Control and Analysis of its Functionality

  Okeyo Kennedy O.; Omasa Naoya; Kurosawa Shu; Oana Hidehiro; Washizu Masao

  バイオエンジニアリング講演会講演論文集, 10 Jan. 2014

  
• 相同組換えタンパクをプローブに用いた標的塩基配列の顕微鏡下リアルタイム探索

  東郷智之; ケネディ オケヨ; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2014

  
• 細胞核内に直接導入したプラスミドの遺伝子発現の細胞周期依存性

  黒澤修; 松永明浩; ケネディーオモンディ オケヨ; 小穴英廣; 小寺秀俊; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2014

  
• 電場を用いた細胞マニピュレーションとその新展開 4 電界集中を用いた超高収率細胞融合技術

  阪本祥太; ケネディ オケヨ; 鷲津正夫

  電気化学および工業物理化学, 2014

  
• 微細構造を用いたマイクロ流路内BSAパターニングによる融合細胞の接着・伸展制御

  阪本祥太; ケネディ オケヨ; 黒澤修; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2014

  
• 電気細胞融合による細胞質移植と免疫治療への応用

  板垣雄太郎; ケネディ オケヨ; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2014

  
• 微細構造メッシュシートを用いた万能細胞の安定培養方法の開発

  ケネディ オケヨ; 磯崎泰佑; 黒澤修; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2014

  
• オンチップエレクトロポレーションを用いた接着細胞核への遺伝子直接送達法の開発

  黒澤 修; オケヨ ケネディ オモンディ; 小穴英廣; 沖田圭介; 小寺秀俊; 鷲津正夫

  第37回静電気学会全国大会, Sep. 2013

  
• 抗体修飾マイクロビーズを用いたゲノムDNA・蛋白質複合体の単分子操作技術の開発

  若林貴之; 西川香里; 小穴英廣; オケヨ ケネディ; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2013

  
• ナローイングスリットによる遺伝子混合を伴わない細胞質融合と融合細胞の分離

  阪本祥太; オケヨ ケネディオモンディ; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2013

  
• 1対1細胞融合技術を用いた体細胞初期化に必要なES細胞核数の検討

  阪本祥太; オケヨ ケネディ オモンディ; 小穴英廣; 鷲津正夫

  化学とマイクロ・ナノシステム学会研究会講演要旨集, 2013

  
• OS3-2-1 Study of Cell Reprogramming Dependency on Cell Cycle using Micro-orifice Electroporation Device

  Okeyo Kennedy Omondi; Hayashi Yukako; Oana Hidehiro; Washizu Masao

  マイクロ・ナノ工学シンポジウム, 21 Oct. 2012

  
• Upregulation of Actomyosin Contractility Enhances Mechanical Integrity of Actin \nCytoskeleton in Lamellipodia

  Taiji Adachi; Kennedy O. Okeyo

  18th Congress of the European Society of Biomechanics（ESB2012）（2012.7.1 －4．Lisbon, Portugal）, 2012, Peer-reviewed

  
• Biomechanical Regulation of Actin Cytoskeleton Dynamics in Migrating Cells.

  Taiji Adachi; Kennedy O. Okeyo

  Eighth International Conference on Flow Dynamics（8th ICFD）（2011.11.9-11 Sendai）（Invited Speaker）, 2011, Peer-reviewed

  
• Effect of Cellsubstrate \nInteractions and Actomyosin Contractility on Lamellipodial Protrusion Dynamics on a Microstamped \nSurface.

  Taiji Adachi; Kennedy O. Okeyo; Masuzo Nagasaki; Junko Sunaga; Masaki Hojo; Hidetoshi Kotera

  International Symposium on Mechanobiology（2011.11.4-8 Shanghai, China）（Invited）., 2011, Peer-reviewed

  
• Intimacy Between Actin Network Flow and Turnover in the Lamella of Crawling Fragments

  Kennedy Omondi Okeyo; Taiji Adachi; Masaki Hojo

  BIOPHYSICAL JOURNAL, Jan. 2010

  
• Quantitative \nanalysis of lamellipodial protrusion dynamics on a micropatterning substrate．

  Taiji Adachi; Masuzo Nagasaki; Kennedy O. Okeyo; Junko Sunaga; Masaki Hojo; Hidetoshi Kotera

  第49 回日本生体医工学会大 会，シンポジウム「デバイス技術による細胞解析・制御の最前線」（2010.6.25－27 大阪）, 2010, Peer-reviewed

  

Presentations

• 剛性異方性基板を用いた細胞シートの配向性誘導

  河﨑 貴哉, 木部 善清, オケヨ ケネディ, 安達 泰治

  第32回バイオフロンティア講演会

  
• Cell alignment in response to substrate stiffness anisotropy investigated using membrane-on-mesh substrates

  Takaya KAWASAKI; Yoshikiyo KIBE; Kennedy O. OKEYO; Taiji ADACHI

  The 11th Asian-Pacific Conference on Biomechanics

  
• Macroscale level control of collective cell alignment by tuning stiffness anisotropy

  Kennedy O. Okeyo; Takaya Kawasaki; Yoshikiyo Kibe; Taiji Adachi

  The 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021), 02 Nov. 2021, Invited

  
• Discerning the differentiation potential of human pluripotent stem cells by modulating the adhesion microenvironment

  Kennedy O. Okeyo

  The 11th International Conference on Post-Genomic Technologies, 22 Oct. 2021, Invited

  
• Contribution of tissue morphology to localized changes in pluripotency state assessed using self-organized mouse embryonic stem cell layers on island mesh substrates.

  Kennedy. O. Okeyo

  The 33rd Bioengineering Conference Annual Meeting of Bioengineering Division, The Japan Society of Mechanical Engineers, 26 Jun. 2021, Invited

  
• Instructive Cell Adhesion Microenvironment Direct Self-organization and Differentiation of Stem Cells

  Kennedy O. Okeyo; Yuta Ando; Taiji Adachi

  The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2020), Aug. 2020

  
• 微細加工技術に基づいた細胞機能創成とその応用可展開

  オケヨ・ケネディ・オモンディ

  第 98 回 大阪大学工業会機械工学系技術交流会, 31 Jan. 2020, Invited

  
• Self-organization and Differentiation of Stem Cells by Modulating the Adhesion Microspace

  Kennedy O. Okeyo; Yuta Ando; Yoshikiyo Kibe; Taiji Adachi

  京都大学メディカルイノベーション卓越大学院プログラム「医薬系研究交流サロン」, 29 Jan. 2020, Invited

  
• Tuning the adhesion landscape to derive self-organization and differentiation

  Kennedy O. Okeyo

  Cell Biology, Developmental Biology and Systems Biology Course, and Faculty of Biostudy Annual Retreat, 25 Jan. 2020, Invited

  
• 細胞の微小接着空間制御による自己組織化誘導

  オケヨ・ケネディ・オモンディ

  電気学会研究会「光・量子デバイス研究会」, 08 Jan. 2020, Invited

  
• Fabrication of Bilayer Cellular Systems for Organ-on-a-chip Applications Enabled by the Micromesh Culture Technique

  Microfluidics and Organ on a Chip Asia 2019, 14 Nov. 2019, Invited

  
• Tuning Cell Orientation based on Localized Geometry Sensing during Cell Sheet Formation by the Micromesh Culture Technique

  Cell and Gene Therapy Asia 2019, 12 Nov. 2019, Invited

  
• Self-organization and Differentiation of Stem Cells Triggered Mechanically by Adhesion Restriction using Suspended Microstructured Mesh Substrates

  Kennedy O. Okeyo; Yuta Ando; Taiji Adachi

  The 10th Asian-Pacific Conference on Biomechanics

  
• Probing the self-organization and differentiation of stem cells by modulating the cell culture microenvironment

  Yuta Ando; Kennedy O. Okeyo; Taiji Adachi

  4th Africa International Biotechnology and Biomedical Conference

  
• Mechanobiology of self-assembly and differentiation by stems cells under restricted adhesion condition

  Kennedy O. Okeyo

  研究セミナー, 07 May 2019, Invited

  
• Reconstituting a Bilayer Cellular System Using an Artificial Matrigel Basement Membrane Achieved by the Micromesh Technique

  Kennedy O. Okeyo; Yamada Kai; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  IEEE International Symposium on Micro-Nano Mechatronics and Human Science (MHS2018)

  
• Biophysical Approaches to Organoid Fabrication

  SELECTBIO Cell Therapy Asia, 07 Dec. 2018, Invited

  
• Biophysical approaches to organoid fabrication

  OKEYO KENNEDYOMONDI

  SELECTBIO 3D-Culture & Organoids, Coronado Island, California, USA., 05 Oct. 2018, Invited

  
• Tissue-level control of cell orientation by geometry sensing using a micromesh

  Kennedy Omondi Okeyo; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  World Congress of Biomechanics (WCB 2018), Dublin, Ireland, 09 Jul. 2018

  
• A mesh Culture Technique for Fabricating Organ-on-chip and Organoids

  Kennedyomondi Okeyo

  Organ-on-a-Chip & Tissue-on-a-Chip Europe 2018, Rotterdam, The Netherlands, 06 Jun. 2018, Invited

  
• マイクロメッシュ培養技術による細胞組織構築

  オケヨ ケネディオモンディ

  ，医工学フォーラム－2017年度特別学術講演会，京都リサーチパーク，京都市, 28 Feb. 2018, Invited

  
• Novel micromesh culture method enables self-assembly cell sheet formation and mechanotransduction

  Osamu Kurosawa; Kennedy Omondi Okeyo; H. Iwata; M. Washizu

  International Symposium on Nanomedicine 2017, School of Medicine Centennial Hall, Tohoku University, Sendai, Japan, 13 Dec. 2017

  
• Induction of stem cell self-assembly by adhesion restriction

  Kennedyomondi Okeyo

  Lab-on-a-Chip, Microfluidics & Biosensors Asia 2017, Taipei, Taiwan, 01 Dec. 2017, Invited

  
• Direct observation-based analysis of compaction stability of individual chromosomes isolated from single mammalian cells

  Hidehiro Oana; Tomohiro Takahashi; Kennedy O. Okeyo; Jun Ueda; Masao Washizu

  MiroTAS 2017, Savannah, Atlanta USA, 22 Oct. 2017

  
• Integrating Microfluidics and Tissue Engineering for Organ-on-a Chip Applications

  Kennedy Omondi Okeyo

  Lab-on-a-Chip and Microfluidics World Congress 2017, Coronado Island, California, USA, 05 Oct. 2017, Invited

  
• Basic Study of iPS Cell Culture Substrate by using Metal Micro Mesh Device

  Maiko Tanabe; Kennedy Omondi Okeyo; Masahiro Okanojo; Hiroko Hanzawa; Masao Washizu; Shizu Takeda

  Lab-on-a-Chip and Microfluidics World Congress 2017, Coronado Island, California, USA, 02 Oct. 2017

  
• Self-organized Morphological Changes in ES Cells on Adhesion-restricted Substrates

  Yuta Ando; Kennedy O. Okeyo; Taiji Adachi

  5th Switzerland-Japan Workshop on Biomechanics (SJB2017), Zermatt, Switzerland, 14 Sep. 2017

  
• Fabrication of in vitro tissue/organ models for disease modeling and drug development

  Kennedy Omondi Okeyo

  The 3rd Africa International Biotechnology and Biomedical Conference (AIBBC 2017), Sino Africa Joint Research Center, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Juja, Kenya, 12 Sep. 2017

  
• Direct observation-based analysis of compaction stability of individual chromosomes isolated from single mammalian cells

  Yamada Kai; Kennedy O. Okeyo; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  Transducers 2017, Kaohsiung, Taiwan, 18 Jun. 2017

  
• Optical Mapping of Epigenetic Information along Intact Chromatin Fibers isolated from Single Cells in a Microchannel

  Kennedyomondi Okeyo

  Tomohiro Takahashi, Kennedy O. Okeyo, Masao Washizu, Jun Ueda, Hidehiro Oana, 18 Dec. 2016

  
• Fabrication of bilayer cell sheet structures with direct cross-layer cell-cell contact using the mesh culture technique

  Kai Yamada; Kennedy O. Okeyo; Osamu Kurosawa; Hidehiro Oana; Masao Washizu

  International Symposium on Micro-Nano Science and Technology 2016, Tokyo, 18 Dec. 2016

  
• Direct Acquisition of Epigenetic Information along Chromatin Fibers Isolated from Single Mammalian Cell

  Tomohiro Takahashi; Kennedy O. Okeyo; Masao Washizu; Jun Ueda; Hidehiro Oana

  The 2016 International Conference on Solid State Devices and Materials (SSDM2016), Tsukuba, Japan, 29 Sep. 2016

  
• Step by step fabrication of biomaterials based on cell adhesion control, Lab-on-a-Chip

  Kennedy Omondi Okeyo

  Lab-on-a-Chip, Microfluidics & Microarrays World Congress, Marriott Hotel Mission Valley, San Diego, USA, 26 Sep. 2016, Invited

  
• Direct Observation of Epigenetic Modifications along Intact Chromatin Fibers of Individual Chromosomes Isolated from Single Cells in a Microfluidic Channel

  Tomohiro Takahashi; Kennedy O. Okeyo; Masao Washizu; Jun Ueda; Hidehiro Oana

  The 2016 International Conference on Solid State Devices and Materials (SSDM2016), Tsukuba, 26 Sep. 2016

  
• Mechanical induction of trophoblast-like differentiation in human iPS cells

  Kennedy O. Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Hiromitsu Nakauchi; Masao Washizu

  Cell Symposium, 10 years of iPSCs, Berkeley, California, USA, 25 Sep. 2016

  
• The shoji technique for cell adhesion control and fabrication of cell sheets

  Kennedyomondi Okeyo

  The 77 Japan Society of Applied Physics Autumn Meeting, Niigata Mese, Niigata, Japan, 13 Sep. 2016, Invited

  
• Cell Adhesion Control using Microstructured Meshes Induces Self-Assembly-Mediated Organoid Formation by Human iPS Cells

  Kennedy O. Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2015), 23 Nov. 2015

  
• Microstructured Meshes as Platforms for Cell Culture and Induction of Self-Assembly-Mediated Organoid Formation

  Kennedy Omondi Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  The 28th International Microprocesses and Nanotechnology Conference (MNC 2015), Toyama International Conference Center, Toyama, Japan., 10 Nov. 2015, Invited

  
• Engineering Free Standing 2D and 3D Biostructures by Induction of Self-Assembly Organization of Cells in a Suspension

  Kennedy Omondi Okeyo

  Lab-on-a-Chip, Microfluidics & Microarrays World Congress, San Diego, USA,, 28 Sep. 2015, Invited

  
• Lab-on-a-CD Device for Rapid Sorting of Blood Cells and Real Time Analysis: Toward Early Detection of Malaria

  Kennedy Omondi Okeyo; Osamu KUROSAWA; Hitoshi SUZUKI; Yoshihide SAITO; Masao WASHIZU

  The 2nd Africa International Biotechnology and Biomedical Conference (AIBBC 2015), African Population and Health Research Center, Kitisuru, Nairobi Kenya, 17 Sep. 2015, Invited

  
• Cell Adhesion Minimization Mechanically Triggers Trophoblast Differentiation of hiPS Cells by a Self-Assembly Mediated Process

  Kennedy O. Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  Cell Adhesion Minimization Mechanically Triggers Trophoblast Differentiation of hiPS Cells by a Self-Assembly Mediated Process, 08 Sep. 2015

  
• Mechanical Derivation of Trophoblast Differentiation on a Mesh”, International Symposium on Chromatin Structure, Dynamics and Function

  Kennedy O. Okeyo; Osamu Kurosawa; Satoshi Yamazaki; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  International Symposium on Chromatin Structure, Dynamics and Function, Awaji Yumebutai International Conference Center, Awaji, Japan, 23 Aug. 2015

  
• Measurement of Higher-order Structural Changes of Tethered Chromatin Fibers in a Micro-flow Channel

  Hiroki Mori; Kennedy O. Okeyo; Masao Washizu; Hidehiro Oana

  7th International Symposium on Microchemistry and Microsystems 2015, Kyoto University Katsura Campus, 08 Jun. 2015

  
• A Novel Culture Method Utilizing Micro Structured Shoji-like Meshes for Self-Assembly Driven Fabrication of 2D and 3D Cellular Structures

  Kennedy Omondi Okeyo; Mari Yanaru; Kurosawa Osamu; Masao Washizu

  Joint Meeting of the 1st Africa International Biotechnology & Biomedical Conference and the 8th International Workshop on Approaches to Single-Cell Analysis, Nairobi, Kenya, 09 Sep. 2014, Invited

  
• A New Approach to Cell Culture and Cell Sheet Fabrication by the “Shoji

  Kennedy Omondi Okeyo

  RSC Tokyo International Conference 2014- Analytical Technology Towards Future Society-, Makuhari Convention center, Chiba, Japan., 04 Sep. 2014, Invited

  
• Cell culture on “Shoji” for Self-Assembly Driven Fabrication of 2D and 3D Cellular Structure

  Kennedy Omondi Okeyo

  International Symposium on 3D Tissue Fabrications, May 20-21,2014, Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, Japan., 20 May 2014, Invited

  
• Cell function manipulation using MEMS devices: From cells to sheets

  Kennedy Omondi Okeyo; Naoya Omasa; Shota Sakamoto; Osamu Kurosawa; Hidehiro Oana; Hidetoshi Kotera; Masao Washizu

  Frontiers of Single Cell Analysis, Palo Alto City, California, 05 Sep. 2013, Invited

  
• Initialization and cell cycle study of single cells using micro-orifice electroporation device

  Kennedy Omondi Okeyo

  International Joint Symposium on Single-Cell Analysis (The 6th International Workshop on Approaches to Single-Cell Analysis & The 8th International Forum on Post-Genome Technologies), Kyoto Research Park, Kyoto, Japan, 27 Nov. 2012, Invited

  
• Biomechanical regulation of actin cytoskeleton dynamics in migrating cells

  Taiji Adachi; Kennedy Omondi Okeyo; Masaki Hojo

  Eighth International Conference on Flow Dynamics (8th ICFD), Sendai, Japan, 09 Nov. 2011, Invited

  
• Effect of cell-substrate interactions and actomyosin contractility on lamellipodial protrusion dynamics on a micro-stamped surface

  Taiji Adachi; Kennedy Omondi Okeyo; Masuzo Nagasaki; Junko Sunaga; Masaki Hojo; Hidetoshi Kotera

  International Symposium on Mechanobiology (The 5th Shanghai International Conference on Biophysics and Molecular Biology) Shanghai, China, 04 Nov. 2011, Invited

  
• Observation of cell orientation dynamics during cell sheet formation on a microstructured mesh substrate

  木部善清; オケヨケネディ; 安達泰治

  日本機械学会第31回バイオエンジニアリング講演会, 14 Dec. 2018

  
• Fabrication of orientated myoblast cell sheets by modulating cell-substrate adhesion

  木部 善清; オケヨ ケネディ; 安達 泰治

  日本機械学会2018年度年次大会, 11 Sep. 2018

  
• Orientation of myoblast cell sheets fabricated using microstructured substartes

  木部 善清; オケヨ ケネディ; 安達 泰治

  第30回バイオエンジニアリング講演会, 14 Dec. 2017

  

Books and Other Publications

• Recent Advances in iPSC-Derived Cell Types, Volume 4, 1st Edition

  Kennedy O. Okeyo; Osamu Kurosawa; Zhousi Li, Chapter 8, Induction of trophoblast differentiation in human-induced pluripotent stem cells by cell adhesion restriction

  Academic Press (Elsevier), Feb. 2021

  
• 3次元細胞システム設計論

  新井, 健生, Joint work

  コロナ社, 2016

  Find Kyoto University's collection of books :

  
• Biochip Technologies- Principles and Applications-

  伊藤, 嘉浩, Joint work, 第II編 バイオチップの応用展開 第４章 細胞チップ，組織チップ

  シーエムシー出版, Oct. 2015

  Find Kyoto University's collection of books :

  
• Innovative Approaches to Cell Biomechanics: From Cell Migration to On-Chip Manipulation

  Kennedy Omondi Okeyo; Hiromi Miyoshi; Taiji Adachi, Joint work

  Springer, Mar. 2015, Not refereed

  

Industrial Property Rights

• 特開2020-036621, 特願2019-224173, 細胞培養支持体, 細胞培養装置, 細胞培養キット, 及び細胞シート

  オケヨ・ケネディ; 鷲津正夫; 小寺秀俊

  
• 特開2019-176793, 特願2018-068090, 細胞製造装置

  岡野定雅弘; 武田志津; オケヨ・ケネディ; 鷲津正夫

  
• 特開2019-135998, 特願2018-023387, 細胞質交換装置

  岡野定雅弘; 武田志津; オケヨ・ケネディ; 鷲津正夫

  
• 特開2019-050773, 特願2017-177814, 細胞培養基材、細胞培養容器、及び細胞培養方法

  田邉麻衣子; 武田志津; 岡野定雅弘; 半澤宏子; 鷲津正夫; オケヨ・ケネディ

  
• 特開2018-148809, 特願2017-045821, 細胞質交換装置

  岡野定雅弘; 武田志津; オケヨ・ケネディ; 鷲津正夫

  
• 特開2018-074982, 特願2016-220953, 細胞質の交換方法、細胞の製造方法、及び装置

  岡野定雅弘; 武田志津; オケヨ・ケネディ; 鷲津正夫

  
• 特願2020-199782, 構造体，細胞培養装置，配向した細胞シートならびに配向した細胞シート形成を誘導する方法

  安達泰治; オケヨ・ケネディ

  

Awards

• Nov. 2019

  The 10th Asian-Pacific Conference on Biomechanics (AP Biomech 2019), Best Oral Presentation Award
• Dec. 2018

  IEEE/MHS Micro-NanoMechatronics and Human Science, Best Paper Award
• Oct. 2018

  Royal Society of Chemistry, Lab on a Chip Poster Prize
• Apr. 2016

  Microtechnologies in Medicine and Biology (MMB2016), Best Poster Award
• Nov. 2015

  IEEE/, NAGOYA 2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2015), BEST PAPER AWARD
• Apr. 2014

  一般社団法人日本機械学会, 日本機械学会奨励賞（研究）
• Mar. 2010

  Journal of Biomechanical Science and Engineering (JBSE), Paper of the Year
• Jan. 2009

  帝人株式会社, 「帝人21世紀フォーラム（2009）」奨励賞
• 03 Nov. 2019

  The 10th Asian-Pacific Conference on Biomechanics (AP Biomech 2019), CHANG YUNG-FA FOUNDATION International Convention Center, Taipei, Taiwan, Best Oral Presentation Award
• 11 Dec. 2018

  2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS2018), IEEE/MHS BEST PAPER AWARD
• 02 Oct. 2018

  SELECTBIO Single Cell Analysis Summit 2018, San Diego, California, USA, Lab on a Chip Poster Prize
• 22 Apr. 2016

  Microtechnologies in Medicine and Biology (MMB2016), Seoul, Korea, Best Poster Award
• 25 Nov. 2015

  NAGOYA 2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS2015) , IEEE/MHS BEST PAPER AWARD
• 18 Apr. 2014

  一般社団法人日本機械学会, 日本機械学会奨励賞（研究）
• 29 Mar. 2013

  Journal of Biomechanical Science and Engineering, Paper of the Year
• 30 Jan. 2009

  帝人株式会社, 帝人株式会社「帝人21世紀フォーラム（2009）」奨励賞　

External funds: Kakenhi

• ヒト未分化細胞から誘導した肺上皮細胞のメッシュ上培養を用いた感染症研究への展開

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53030:Respiratory medicine-related

  Kyoto University

  伊藤 功朗

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  COVID-19;肺胞上皮細胞;未分化細胞;新型コロナウイルス;サイトカイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02925/
• ラベルフリーで多重感染定量検出可能なCD型EISのケニアにおける検証研究

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 90:Biomedical engineering and related fields

  Chiba University

  武居 昌宏

  From 27 Oct. 2020, To 31 Mar. 2024, Granted

  電気計測;インピーダンス;スペクトロスコピー;感染症;アフリカ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20KK0251/
• 細胞質移植マイクロ流体デバイス開発による高収率・細胞機能改変手法の創製

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 28:Nano/micro science and related fields

  The University of Tokyo

  小穴 英廣

  From 30 Jul. 2020, To 31 Mar. 2023, Granted

  マイクロ流体デバイス;免疫治療;細胞医療;細胞質移植

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20551/
• Development of novel therapies for idiopathic pulmonary pneumonia with a human primary lung epithelial cell model

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53030:Respiratory medicine-related

  Kyoto University

  今井 晶; 松島晶

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  ヒト初代肺胞上皮細胞;特発性間質性肺炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08566/
• Reconstitution of Physiologically Relevant 3D Blood-Brain Barrier Model for the Elucidation of its Selective Transport Mechanism

  Grant-in-Aid for Scientific Research (B)

  Basic Section 28050:Nano/micro-systems-related

  Kyoto University

  オケヨ ケネディオモンディ

  From 01 Apr. 2020, To 31 Mar. 2023, Granted

  血液脳関門;三次元培養;マイクロメッシュ培養法;細胞接着制御;血管細胞シート;３次元培養;脳幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02594/
• Development of functional bronchial ciliated cell sheet from human iPS cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Isao Ito

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  未分化細胞;メッシュシート;気液界面培養;培養;肺胞上皮;iPS細胞;組織幹細胞;マイクロメッシュ;マイクロ流体デバイス;肺胞上皮細胞;血管内皮細胞;メッシュ;二層構造;再生医学;ナノバイオ;発生・分化;内科;マイクロ・デバイス;マイクロ・ナノデバイス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04183/
• Development of a microdevice for the study of the interaction between endothelial cells and neuronal cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University;The University of Tokyo

  Kennedy Omondi Okeyo

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ３次元共培養デバイス;血管ー神経相互作用;血液脳関門;メッシュ培養技術;細胞間相互作用;密着結合;マイクロメッシュ培養法;異種細胞間相互作用;物質輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K17501/
• Cell-fusion-based single-cell surgery and its application to epigenetic studies

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Masao WASHIZU

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  マイクロ・ナノデバイス;再生医療;静電気工学;細胞融合;バイオナノテクノロジー;移植・再生医療;静電気

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02009/
• Toward Developing a Microdevice for Elucidating the Mechanism of Blood-Nerve Interactions

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  Kennedy Omondi OKEYO

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  細胞接着制御;メッシュ培養法;細胞シート;血管ー神経モデル;共培養システム;物質輸送計測;マイクロデバイス;細胞・基板相互作用;細胞シートの重層化;体外モデル;細胞間相互作用;微細構造メッシュシート

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25790034/
• Development of a method for the epigenetic analysis of single cells under a micro fluidic device

  Grant-in-Aid for Scientific Research (B)

  The University of Tokyo

  Hidehiro Oana

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  ゲノム;DNA;マイクロ流体デバイス;バイオテクノロジー;マイクロ・ナノデバイス;シングルセル;エピジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25286035/
• 局所的細胞融合技術を用いたミトコンドリア移植とその生物学的応用に関する研究

  Grant-in-Aid for Research Activity Start-up

  The University of Tokyo

  オケヨ ケネディオモンディ

  From 31 Aug. 2012, To 31 Mar. 2014, Declined

  ミトコンドリア移植;電気的細胞融合;微細加工;形質変換

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24810003/
• Modification of cellular function based on cell fusion in microdevices

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  MASAO WASHIZU

  From 01 Apr. 2011, To 31 Mar. 2015, Project Closed

  ナノ・マイクロ科学;細胞融合;初期化;再生医療;静電気;ES細胞;微細加工;マイクロ・ナノデバイス;バイオテクノロジー;マイクロアレイ;バイオナノテクノロジー;自己形成メニスカス;細胞質移植

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23241041/

External funds: others

• 微小培養環境制御に基づく幹細胞組織のメカノバイオロジー研究

  国立研究開発法人 日本医療開発機構 革新的先端研究開発支援事業 PRIME「メカノバイオロジー機構の解明による革新的医療機器及び医療技術の創出」

  From 2017, To 31 Mar. 2021

  オケヨ ケネディオモンディ
• The 4th Africa International Biotechnology and Biomedical Conference & Workshops (AIBBC 2019)

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2019, To 31 Mar. 2020

  オケヨ ケネディ　オモンディ
• The 3rd Africa International Biotechnology and Biomedical Conference & Workshop (AIBBC 2017)

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2017, To 31 Mar. 2018

  オケヨ ケネディ オモンディ
• The 1st Africa International Biotechnology and Biomedical Conference & Workshop (AIBBC 2014)

  二国間交流事業共同研究・セミナー

  From 10 Sep. 2014, To 12 Sep. 2014

  オケヨ ケネディ オモンディ

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Physics A-E2

  N261, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar-E2

  Z002, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physics for All-E2

  N260, Fall, Institute for Liberal Arts and Sciences, 2
• From Apr. 2017, To Mar. 2018

  Fundamental Physics A-E2

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  ILAS Seminar-E2

  Fall, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Physics for All-E2

  Fall, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Advanced Course in Multicellular Network

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Fundamental Physics A-E2

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  ILAS Seminar-E2

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Physics for All-E2

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Fundamental Physics A-E2

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  ILAS Seminar-E2

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Physics for All-E2

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Microsystem Engineering

  Fall, 工学研究科
• From Apr. 2020, To Mar. 2021

  Fundamental Physics A-E2

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  ILAS Seminar-E2 :Discussions in Biomechanics and Biophysics

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  ILAS Seminar-E2 :Introduction to Engineering in Biology and Medicine

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Micro/bio system

  Spring, 工学研究科
• From Apr. 2020, To Mar. 2021

  Physics for All-E2

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced Course in Multicellular Network

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Engineering Science A

  Fall, 工学部
• From Apr. 2020, To Mar. 2021

  Introduction to Engineering Science A

  Fall, 工学部
• From Apr. 2021, To Mar. 2022

  Fundamental Physics A-E2

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  ILAS Seminar-E2 :Discussions in Biomechanics and Biophysics

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  ILAS Seminar-E2 :Introduction to Engineering in Biology and Medicine

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Micro/bio system

  Spring, 工学研究科
• From Apr. 2021, To Mar. 2022

  Physics for All-E2

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Advanced Course in Multicellular Network

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Engineering Science A

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Introduction to Engineering Science A

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科

Student achievements: Awards

• Outstanding Presentation 賞

  木部善清, 日本機械学会　バイオエンジニアリング部門　第31回バイオエンジニアリング講演会, 14 Dec. 2018

Administration

Faculty management (title, position)

• From 01 Oct. 2018

  教育委員会　委員

Academic, Social Contribution

Committee Memberships

• From Apr. 2018, To Present

  International Union, Japan Society of Mechanical Engineers (JSME)
• From Apr. 2014, To Present

  Organizing Committee, Africa International Biotechnology and Biomedical Conference (AIBBC)
• From Jun. 2020, To Nov. 2020

  Social Committee, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
• From 2018, To 2018

  日本機械学会バイオエンジニアリング講演会実行委員, 日本機械学会
• From Feb. 2017, To Dec. 2017

  Executive committee, The 30th Bioengineering Conference Annual Meeting of Bioengineering Division/ The Japan Society of Mechanical Engineers
• From Jan. 2013

  イノバイオ研究会定例会企画員, 若手細胞研究会
• From Sep. 2012

  イノバイオ研究会定例会企画員, 若手細胞研究会

Academic Contribution

• The 5th Africa International Biotechnology and Biomedical Conference (AIBBC 2021)

  Planning, management, etc.

  KISUMU, KENYA, From 08 Nov. 2021, To 13 Nov. 2021

  
• Africa International Biotechnology and Biomedical Conference & Workshops 2020 in the Covid-19 Era (AIBBC 2020)

  Planning, management, etc.

  From 05 Nov. 2020, To 06 Nov. 2020

  
• The 4th Africa International Biotechnology and Biomedical Conference & Workshops (AIBBC 2019)

  Planning, management, etc.

  From 26 Aug. 2019, To 31 Aug. 2019

  
• The 3rd Africa International Biotechnology and Biomedical Conference & Workshops (AIBBC 2017)

  Planning, management, etc.

  From 12 Sep. 2017, To 15 Sep. 2017

  
• The 2nd Africa International Biotechnology and Biomedical Conference (AIBBC 2015)

  Planning, management, etc.

  From 17 Sep. 2015, To 18 Sep. 2015

  
• Joint Meeting of the 1st Africa International Biotechnology & Biomedical Conference and the 8th International Workshop on Approaches to Single-Cell Analysis

  Planning, management, etc.

  From 10 Sep. 2014, To 12 Sep. 2014