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Nomura, Wataru

Graduate School of Agriculture, Division of Applied Life Sciences

Nomura, Wataru
list
    Last Updated :2022/06/29

    Basic Information

    Professional Memberships

    • JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
    • THE JAPANESE BIOCHEMICAL SOCIETY
    • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
    • THE YEATS SOCIETY OF JAPAN
    • 日本生物工学会

    Academic Degree

    • 修士(理学)(静岡大学)
    • 博士(農学)(京都大学)

    Research History

    • From Apr. 2021, To Present
      京都大学大学院 農学研究科 特任助教(生理化学研究ユニット)
    • From Apr. 2016, To Mar. 2021
      京都大学大学院, 農学研究科, 特定助教
    • From Apr. 2015, To Mar. 2016
      京都大学大学院, 農学研究科, 教務補佐員
    • From Apr. 2012, To Mar. 2015
      日本学術振興会特別研究員(PD)
    • From Apr. 2010, To Mar. 2012
      京都大学大学院, 農学研究科, 研究員等

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/29

      Research

      Research Interests

      • 酵母
      • シグナル伝達
      • 代謝物
      • 脂肪細胞

      Research Areas

      • Life sciences, Applied molecular and cellular biology
      • Life sciences, Food sciences
      • Life sciences, Molecular biology
      • Life sciences, Applied microbiology

      Papers

      • Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.
        Su-Ping Ng; *Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; *Tsuyoshi Goto (* Corresponding authors)
        Biochemistry and biophysics reports, Dec. 2021, Peer-reviewed, Corresponding author
      • Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae.
        *Wataru Nomura; Ryota Futamata; *Yoshiharu Inoue (* Corresponding authors)
        Biochimica et biophysica acta. General subjects, 25 Jan. 2021, Peer-reviewed, Corresponding author
      • Metabolome analysis revealed that soybean-Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes.
        Haruya Takahashi; Koji Ochiai; Kuni Sasaki; Atsushi Izumi; Yu Shinyama; Shinsuke Mohri; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
        PloS one, 2021, Peer-reviewed
      • Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae.
        *Wataru Nomura; Miho Aoki; *Yoshiharu Inoue (* Corresponding authors)
        Scientific reports, 17 Aug. 2020, Peer-reviewed, Corresponding author
      • Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes.
        Mari Iwase; Soshi Tokiwa; Shigeto Seno; Takako Mukai; Yu-Sheng Yeh; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Sigenobu Matsumura; Tatsuya Kusudo; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
        The Journal of biological chemistry, 15 May 2020, Peer-reviewed
      • Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy.
        Huei-Fen Jheng; Kanako Hayashi; Yasuki Matsumura; Teruo Kawada; Shigeto Seno; Hideo Matsuda; Kazuo Inoue; Wataru Nomura; Haruya Takahashi; Tsuyoshi Goto
        Molecular nutrition & food research, May 2020, Peer-reviewed
      • Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes.
        Mari Iwase; Shoko Sakai; Shigeto Seno; Yu-Sheng Yeh; Tony Kuo; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Paul Horton; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
        Bioscience, biotechnology, and biochemistry, Feb. 2020, Peer-reviewed
      • Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism.
        Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Su-Ping Ng; Jungin Kwon; Shinsuke Mohri; Mari Iwase; Huei-Fen Jheng; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
        Diabetes, metabolic syndrome and obesity : targets and therapy, 2020, Peer-reviewed
      • Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae.
        Nomura W; Inoue Y
        Small GTPases, Nov. 2019, Peer-reviewed
      • Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes.
        Ng SP; Nomura W; Mohri S; Takahashi H; Jheng HF; Ara T; Nagai H; Ito T; Kawada T; Goto T
        Bioscience, biotechnology, and biochemistry, Sep. 2019, Peer-reviewed, Corresponding author
      • A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.
        Kawarasaki S; Kuwata H; Sawazaki H; Sakamoto T; Nitta T; Kim CS; Jheng HF; Takahashi H; Nomura W; Ara T; Takahashi N; Tomita K; Yu R; Kawada T; Goto T
        FEBS letters, Jun. 2019, Peer-reviewed
      • Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
        Kiriyama K; Goto T; Yamamoto H; Ara T; Takahashi H; Jheng HF; Nomura W; Inoue H; Nakata R; Kawada T
        Journal of Functional Foods, Mar. 2019, Peer-reviewed
      • Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes.
        Yuliana A; Daijo A; Jheng HF; Kwon J; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
        International journal of molecular sciences, Jan. 2019, Peer-reviewed
      • 10-Hydroxyoctadecanoic Acid from Lactobacillus amylovorus CP1563 Activates PPARalpha and Improves Dyslipidemia
        Yumeko Aoki; Tomonori Sugawara; Sae Yanagihara; Haruya Takahashi; Wataru Nomura; Jheng Huei-Fen; Takeshi Ara; Tsuyoshi Goto; Teruo Kawada; Daisuke Sawada
        Pharmacometrics, Nov. 2018, Peer-reviewed
      • The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice.
        Takeda K; Sawazaki H; Takahashi H; Yeh YS; Jheng HF; Nomura W; Ara T; Takahashi N; Seno S; Osato N; Matsuda H; Kawada T; Goto T
        FEBS open bio, Nov. 2018, Peer-reviewed
      • The Mevalonate Pathway Is Indispensable for Adipocyte Survival.
        Yeh YS; Jheng HF; Iwase M; Kim M; Mohri S; Kwon J; Kawarasaki S; Li Y; Takahashi H; Ara T; Nomura W; Kawada T; Goto T
        iScience, Nov. 2018, Peer-reviewed
      • β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte.
        Yuliana A; Jheng HF; Kawarasaki S; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
        International journal of molecular sciences, Aug. 2018, Peer-reviewed
      • Toxicity of dihydroxyacetone is exerted through formation of methylglyoxal in Saccharomyces cerevisiae : effects on actin polarity and nuclear division.
        Nomura W; Aoki M; Inoue Y
        The Biochemical journal, Jul. 2018, Peer-reviewed
      • Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes
        Ha-Eun Yang; Yongjia Li; Akira Nishimura; Huei-Fen Jheng; Ana Yuliana; Ryuji Kitano-Ohue; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada; Tsuyoshi Goto
        MOLECULAR NUTRITION & FOOD RESEARCH, Oct. 2017, Peer-reviewed
      • Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade in Saccharomyces cerevisiae
        Wataru Nomura; Kazuhiro Maeta; Yoshiharu Inoue
        JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2017, Peer-reviewed
      • Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPAR gamma Activation
        Mari Iwase; Takayuki Yamamoto; Kanako Nishimura; Haruya Takahashi; Shinsuke Mohri; Yongjia Li; Huei-Fen Jheng; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Masahiko Taniguchi; Kimiye Baba; Shigeru Murakami; Teruo Kawada; Tsuyoshi Goto
        LIPIDS, Jul. 2017, Peer-reviewed
      • The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-alpha agonist-induced amelioration of metabolic disorders in obese mice
        Tsuyoshi Goto; Mariko Hirata; Yumeko Aoki; Mari Iwase; Haruya Takahashi; Minji Kim; Yongjia Li; Huei-Fen Jheng; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Shigeto Seno; Hideo Matsuda; Megumi Aizawa-Abe; Ken Ebihara; Nobuyuki Itoh; Teruo Kawada
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2017, Peer-reviewed
      • Role of phosphatidylserine in the activation of Rho1-related Pkc1 signaling in Saccharomyces cerevisiae
        Wataru Nomura; Yusuke Ito; Yoshiharu Inoue
        CELLULAR SIGNALLING, Feb. 2017, Peer-reviewed
      • 4-Hydroxyderricin, as a PPAR gamma Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells
        Yongjia Li; Tsuyoshi Goto; Kanae Yamakuni; Haruya Takahashi; Nobuyuki Takahashi; Huei-Fen Jheng; Wataru Nomura; Masahiko Taniguchi; Kimiye Baba; Shigeru Murakami; Teruo Kawada
        LIPIDS, Jul. 2016, Peer-reviewed
      • 代謝ストレスによるTORシグナルの活性化
        野村 亘; 井上善晴
        化学と生物, Apr. 2016, Peer-reviewed
      • Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae
        Wataru Nomura; Yoshiharu Inoue
        MOLECULAR AND CELLULAR BIOLOGY, Apr. 2015, Peer-reviewed
      • 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPAR gamma and stimulates adipogenesis
        Tsuyoshi Goto; Young-Il Kim; Tomoya Furuzono; Nobuyuki Takahashi; Kanae Yamakuni; Ha-Eun Yang; Yongjia Li; Ryuji Ohue; Wataru Nomura; Tatsuya Sugawara; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2015, Peer-reviewed
      • 13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor gamma in Adipocytes
        Haruya Takahashi; Hideyuki Hara; Tsuyoshi Goto; Kosuke Kamakari; Nomura Wataru; Shinsuke Mohri; Nobuyuki Takahashi; Hideyuki Suzuki; Daisuke Shibata; Teruo Kawada
        LIPIDS, Jan. 2015, Peer-reviewed
      • Reduction of Glucose Uptake through Inhibition of Hexose Transporters and Enhancement of Their Endocytosis by Methylglyoxal in Saccharomyces cerevisiae
        Aya Yoshida; Dandan Wei; Wataru Nomura; Shingo Izawa; Yoshiharu Inoue
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2012, Peer-reviewed
      • Glyoxalase system in yeasts: Structure, function, and physiology
        Yoshiharu Inoue; Kazuhiro Maeta; Wataru Nomura
        SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, May 2011, Peer-reviewed
      • Methylglyoxal activates Gcn2 to phosphorylate eIF2 alpha independently of the TOR pathway in Saccharomyces cerevisiae
        Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
        APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, May 2010, Peer-reviewed
      • Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae
        Yoshifumi Takatsume; Takumi Ohdate; Kazuhiro Maeta; Wataru Nomura; Shingo Izawa; Yoshiharu Inoue
        BIOCHEMICAL JOURNAL, Apr. 2010, Peer-reviewed
      • Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: Methylglyoxal attenuates protein synthesis through phosphorylation of eIF2 alpha
        Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2008, Peer-reviewed
      • Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol
        Yoko Takeuchi; Wataru Nomura; Takumi Ohdate; Shogo Tamasu; Hiroshi Masutani; Kazuo Murata; Shingo Izawa; Junji Yodoi; Yoshiharu Inoue
        APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, Jul. 2007, Peer-reviewed
      • Efficient extraction of thioreodoxin from Saccharomyces cerevisiae by ethanol
        Yoshiharu Inoue; Wataru Nomura; Yoko Takeuchi; Takumi Ohdate; Shogo Tamasu; Atsushi Kitaoka; Yoshifumi Kiyokawa; Hiroshi Masutani; Kazuo Murata; Yoshinori Wakai; Shingo Izawa; Junji Yodoi
        APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Mar. 2007, Peer-reviewed
      • Green tea polyphenols function as prooxidants to activate oxidative-stress-responsive transcription factors in yeasts
        Kazuhiro Maeta; Wataru Nomura; Yoshifumi Takatsume; Shingo Izawa; Yoshiharu Inoue
        APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jan. 2007, Peer-reviewed

      Presentations

      • 膜ストレスを感知するTORシグナルの制御機構
        野村 亘
        生理化学研究ユニット第10回シンポジウム, 25 Dec. 2020
      • 出芽酵母のストレス応答におけるPKCシグナルの制御機構
        野村 亘
        酵母研究会 第85回講演会, 27 Jul. 2018
      • 酵母のストレス応答におけるPKCシグナル制御機構に関する研究
        野村 亘
        第65回 日本生化学会近畿支部例会 近畿支部奨励賞受賞記念講演, 26 May 2018
      • 解糖系代謝物によるTORC2シグナルの活性化
        野村 亘; 河田照雄; 井上善晴
        第36回 日本分子生物学会年会 ワークショップ, 05 Dec. 2013

      Books and Other Publications

      • 脂肪酸および脂肪酸代謝物が褐色脂肪組織機能に及ぼす影響~ω-3脂肪酸を中心に~
        後藤剛; 岩瀬麻里; 川原崎聡子; 高橋春弥; 野村亘; 井上和生; 河田照雄, Joint work
        BIO INDUSTRY (シーエムシー出版), Oct. 2020
      • 脂肪組織機能を制御する食品由来成分に関する研究
        岩瀬麻里; 川原崎聡子; 毛利晋輔; 高橋春弥; 野村亘; Huei-Fen Jheng; 井上和生; 河田照雄; 後藤剛, Joint work
        日本機能性食品医用学会, 2020
      • The Yeast Role in Medical Applications
        Yoshiharu Inoue; Wataru Nomura, Contributor, TOR signaling in budding yeast
        InTechOpen, Jan. 2018, Not refereed

      External funds: Kakenhi

      • TORC2シグナルの活性化に寄与する細胞膜脂質の作用機序の解析
        Grant-in-Aid for Scientific Research (C)
        Basic Section 38060:Applied molecular and cellular biology-related
        Kyoto University
        野村 亘
        From 01 Apr. 2019, To 31 Mar. 2022, Granted
        TORC2;yeast;シグナル伝達;PKC;エルゴステロール;酵母;脂肪細胞
      • Analysis of the regulation of TORC2 signaling by phosphatidylserine
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Wataru Nomura
        From 01 Apr. 2017, To 31 Mar. 2019, Project Closed
        TORC2;Pkc1;Rho1;ホスファチジルセリン;酵母;シグナル伝達
      • Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance development
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Wataru Nomura
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        メチルグリオキサール;インスリンシグナル;インスリン抵抗性;IRS-1;mTORC1
      • 酵母におけるプロテインキナーゼCによるTORC2シグナルの負の制御
        Grant-in-Aid for Scientific Research (C)
        Basic Section 38060:Applied molecular and cellular biology-related
        Kyoto University
        野村 亘
        From 01 Apr. 2022, To 31 Mar. 2025, Adopted
      list
        Last Updated :2022/06/29

        Education

        Teaching subject(s)

        • From Apr. 2017, To Mar. 2018
          Laboratory Course in Food Biochemistry (II)
          Spring, 農学部
        • From Apr. 2018, To Mar. 2019
          Outline of Physiological Chemistry
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Laboratory Course in Food Biochemistry (II)
          Spring, 農学部
        • From Apr. 2019, To Mar. 2020
          Advanced Course of Metabolism and Nutritional Chemistry
          Fall, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Laboratory Course in Food Biochemistry
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Experimental Course in Molecular Function of Food1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Experimental Course in Molecular Function of Food2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar in Molecular Function of Food1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar in Molecular Function of Food2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Food Biochemistry
          Spring, 農学部

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