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Perron, Amelie

Institute for Chemical Research (ICR) Senior Lecturer/ Junior Associate Professor

Perron, Amelie
list
    Last Updated :2022/06/23

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Medicine, 医科学専攻 ケミカルバイオロジー, 講師
    • Graduate School of Medicine, 医学専攻 ケミカルバイオロジー, 講師

    Faculty

    • Institute for Liberal Arts and Sciences (ILAS)
    • 国際高等教育院

    Concurrent Affiliation

    • Institute for Advanced Study, 物質-細胞統合システム拠点, 連携講師

    Academic Degree

    • Immunology
    • Neurosciences

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/23

      Research

      Research Topics, Overview of the research

      • Research Topics

        Chemical Biology
      • Overview of the research

        The focus of my current research is on the development of small organic molecules and molecular self-assemblies to control the aggregation of pigments from the retina associated with age-related macular degeneration (AMD).

      Research Interests

      • Fluorescence
      • Neuroscience
      • Organic Self-Assemblies
      • Bioactive Molecules
      • Chemical Biology

      Research Areas

      • Life sciences, Cell biology
      • Life sciences, Neuroscience - general
      • Nanotechnology/Materials, Chemical biology

      Papers

      • Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells.
        Genyir Ado; Naotaka Noda; Hue T. Vu; Amelie Perron; Amarjyoti D. Mahapatra; Karla Pineda Arista; Hideaki Yoshimura; Daniel M. Packwood; Fumiyoshi Ishidate; Shin-ichi Sato; Takeaki Ozawa; Motonari Uesugi
        May 2022
      • Fluorescent sensors of membrane potential that are genetically encoded
        L. Jin; B. J. Baker; Lawrence B. Cohen; H. Mutoh; D. Dimitrov; A. Perron; Y. Iwamoto; E. Y. Isacoff; V. A. Pieribone; T. Hughes; T. Knöpfel; W. Akemann
        Imaging the Brain with Optical Methods, 2010, Peer-reviewed
      • Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone
        Amelie Perron; Yoshihiro Nishikawa; Jun Iwata; Hiromi Shimojo; Junichiro Takaya; Kumiko Kobayashi; Itaru Imayoshi; Naasson M. Mbenza; Mihoko Takenoya; Ryoichiro Kageyama; Yuzo Kodama; Motonari Uesugi
        Journal of Biological Chemistry, 2018, Peer-reviewed
      • Spinal NTS2 receptor activation reverses signs of neuropathic pain
        Pascal Tetreault; Nicolas Beaudet; Amelie Perron; Karine Belleville; Adeline Rene; Florine Cavelier; Jean Martinez; Thomas Stroh; Ashley M. Jacobi; Scott D. Rose; Mark A. Behlke; Philippe Sarret
        FASEB JOURNAL, Sep. 2013, Peer-reviewed
      • Imaging neural circuit dynamics with a voltage-sensitive fluorescent protein
        Walther Akemann; Hiroki Mutoh; Amelie Perron; Yun Kyung Park; Yuka Iwamoto; Thomas Knoepfel
        JOURNAL OF NEUROPHYSIOLOGY, Oct. 2012, Peer-reviewed
      • Genetically encoded probes for optical imaging of brain electrical activity
        Amelie Perron; Walther Akemann; Hiroki Mutoh; Thomas Knoepfel
        OPTOGENETICS: TOOLS FOR CONTROLLING AND MONITORING NEURONAL ACTIVITY, 2012, Peer-reviewed
      • Optogenetic monitoring of membrane potentials
        Hiroki Mutoh; Amelie Perron; Walther Akemann; Yuka Iwamoto; Thomas Knoepfel
        EXPERIMENTAL PHYSIOLOGY, Jan. 2011, Peer-reviewed
      • Imaging brain electric signals with genetically targeted voltage-sensitive fluorescent proteins
        Walther Akemann; Hiroki Mutoh; Amelie Perron; Jean Rossier; Thomas Knoepfel
        NATURE METHODS, Aug. 2010, Peer-reviewed
      • Red-Shifted Voltage-Sensitive Fluorescent Proteins
        Amelie Perron; Hiroki Mutoh; Thomas Launey; Thomas Knopfel
        CHEMISTRY & BIOLOGY, Dec. 2009, Peer-reviewed
      • Exploration of fluorescent protein voltage probes based on circularly permuted fluorescent proteins
        Sunita Ghimire Gautam; Amelie Perron; Hiroki Mutoh; Thomas Knöpfel
        Frontiers in Neuroengineering, 13 Oct. 2009, Peer-reviewed
      • Second and third generation voltage-sensitive fluorescent proteins for monitoring membrane potential
        Amelie Perron; Hiroki Mutoh; Walther Akemann; Sunita Ghimire Gautam; Dimitar Dimitrov; Yuka Iwamoto; Thomas Knöpfel
        Frontiers in Molecular Neuroscience, 22 Jun. 2009, Peer-reviewed
      • Spectrally-Resolved Response Properties of the Three Most Advanced FRET Based Fluorescent Protein Voltage Probes
        Hiroki Mutoh; Amelie Perron; Dimitar Dimitrov; Yuka Iwamoto; Walther Akemann; Dmitriy M. Chudakov; Thomas Knoepfel
        PLOS ONE, Feb. 2009, Peer-reviewed
      • Genetically encoded fluorescent sensors of membrane potential
        B. J. Baker; H. Mutoh; D. Dimitrov; W. Akemann; A. Perron; Y. Iwamoto; L. Jin; L. B. Cohen; E. Y. Isacoff; V. A. Pieribone; T. Hughes; T. Knopfel
        BRAIN CELL BIOLOGY, Aug. 2008, Peer-reviewed
      • NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization
        Amelie Perron; Nadder Sharif; Philippe Sarret; Thomas Stroh; Alain Beaudet
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2007, Peer-reviewed
      • Sustained neurotensin exposure promotes cell surface recruitment of NTS2 receptors
        A Perron; N Sharif; L Gendron; M Lavallee; T Stroh; J Mazella; A Beaudet
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2006, Peer-reviewed
      • Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors
        P Sarret; MJ Esdaile; A Perron; J Martinez; T Stroh; A Beaudet
        JOURNAL OF NEUROSCIENCE, Sep. 2005, Peer-reviewed
      • Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system
        AL Perron; P Sarret; L Gendron; T Stroh; A Beaudet
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2005, Peer-reviewed
      • Low-affinity neurotensin receptor (NTS2) signaling: Internalization-dependent activation of extracellular signal-regulated kinases 1/2
        L Gendron; A Perron; MD Payet; N Gallo-Payet; P Sarret; A Beaudet
        MOLECULAR PHARMACOLOGY, Dec. 2004, Peer-reviewed
      • Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization
        A Perron; ZG Chen; D Gingras; DJ Dupre; J Stankova; M Rola-Pleszczynski
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2003, Peer-reviewed
      • Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system
        P Sarret; A Perron; T Stroh; A Beaudet
        JOURNAL OF COMPARATIVE NEUROLOGY, Jul. 2003, Peer-reviewed
      • Neuropeptide Y-induced contraction is mediated by NPY Y2 and Y4 receptors in rat colon
        Pheng LH; Perron A; Quirion R; Cadieux A; Fauchère JL; Dumont Y; Regoli D
        European Journal of Pharmacology, 1998, Peer-reviewed

      Misc.

      • Optogenetic electrophysiology
        Walther Akemann; Amelie Perron; Hiroki Mutoh; Thomas Knoepfel
        EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Aug. 2011

      External funds: Kakenhi

      • Small Bioactive Molecules for Orchestrating Embryonic Stem Cell Differentiation
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        AMELIE PERRON
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        SAR Studies;Hes1;Regenerative Medicine;Stem Cells;Oscillations;Microarray;Transcription;Gro/TLE;Embryonic;Hypoxia;Regenerative medicine;Transcription factors;Stem cells

      External funds: others

      • Development of improved monomeric red fluorescent protein and voltage-sensitive protein
        国際交流事業 二国間交流事業 共同研究
        From 2011, To 2012
        分担
      list
        Last Updated :2022/06/23

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Research Proposal Writing Practice A
          8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Everyday Life Chemistry-E2
          N362, Fall, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Critical Reading of Scientific Papers A
          8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Organic Chemistry II-E2
          N369, Fall, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory Coaching Practice A
          8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Organic Chemistry I-E2
          N368, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Medical Frontier Science Research A
          8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Organic Chemistry of Life-E2
          N361, Spring, Institute for Liberal Arts and Sciences, 2
        • From Apr. 2014, To Mar. 2015
          Basic Organic Chemistry A
          Spring, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Basic Organic Chemistry B
          Fall, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry of Life
          Spring, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Everyday Life Chemistry
          Fall, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Basic Organic Chemistry II
          Fall, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Everyday Life Chemistry
          Fall, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Organic Chemistry of Life
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Basic Organic Chemistry I-E2
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Basic Organic Chemistry II-E2
          Fall, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Everyday Life Chemistry-E2
          Fall, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Organic Chemistry of Life-E2
          Spring, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Basic Organic Chemistry I-E2
          Spring, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Basic Organic Chemistry II-E2
          Fall, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Everyday Life Chemistry-E2
          Fall, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Organic Chemistry of Life-E2
          Spring, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Basic Organic Chemistry I-E2
          Spring, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Basic Organic Chemistry II-E2
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Everyday Life Chemistry-E2
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Organic Chemistry of Life-E2
          Spring, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Basic Organic Chemistry I-E2
          Spring, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Basic Organic Chemistry II-E2
          Fall, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Everyday Life Chemistry-E2
          Fall, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Organic Chemistry of Life-E2
          Spring, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Basic Organic Chemistry I-E2
          Spring, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Basic Organic Chemistry II-E2
          Fall, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Everyday Life Chemistry-E2
          Fall, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Organic Chemistry of Life-E2
          Spring, 全学共通科目
        • From Apr. 2021, To Mar. 2022
          Basic Organic Chemistry II-E2
          Fall, 全学共通科目
        • From Apr. 2021, To Mar. 2022
          Everyday Life Chemistry-E2
          Fall, 全学共通科目
        list
          Last Updated :2022/06/23

          Administration

          School management (title, position)

          • From 01 Aug. 2018, To 30 Sep. 2018
            国際戦略アドバイザリーボード 委員
          • From 01 Oct. 2018, To 30 Sep. 2020
            国際戦略アドバイザリ―ボード 委員

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