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Sawada, Shinichi

Graduate School of Engineering, Division of Polymer Chemistry Assistant Professor

Sawada, Shinichi
list
    Last Updated :2022/05/14

    Basic Information

    Faculty

    • 工学部

    Concurrent Affiliation

    • Center for the Promotion of Interdisciplinary Education and Research (C-PiER), スーパーグローバルコース 化学系ユニット

    Academic Degree

    • 修士(理学)(東邦大学)
    • 博士(学術)(東京医科歯科大学)

    Language of Instruction

    • English
    • Japanese

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      Research

      Research Areas

      • Life sciences, Biomaterials

      Papers

      • A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci
        Rika Nakahashi-Ouchida; Yohei Uchida; Yoshikazu Yuki; Yuko Katakai; Tomoyuki Yamanoue; Hiromi Ogawa; Yoshiko Munesue; Nozomi Nakano; Kouji Hanari; Takashi Miyazaki; Yuki Saito; Shingo Umemoto; Shin-ichi Sawada; Reshmi Mukerji; David E. Briles; Yasuhiro Yasutomi; Kazunari Akiyoshi; Hiroshi Kiyono
        VACCINE, Jun. 2021
      • Magnetically Navigated Protein Transduction In Vivo using Iron Oxide-Nanogel Chaperone Hybrid
        Riku Kawasaki; Yoshihiro Sasaki; Tomoki Nishimura; Kiyofumi Katagiri; Kei-ichi Morita; Yurina Sekine; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi
        ADVANCED HEALTHCARE MATERIALS, May 2021
      • Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System
        Yoshikazu Yuki; Yohei Uchida; Shin-Ichi Sawada; Rika Nakahashi-Ouchida; Kotomi Sugiura; Hiromi Mori; Tomoyuki Yamanoue; Tomonori Machita; Ayaka Honma; Shiho Kurokawa; Reshmi Mukerji; David E. Briles; Kazunari Akiyoshi; Hiroshi Kiyono
        MOLECULAR PHARMACEUTICS, Apr. 2021
      • エクソソームのサブクラス分離へ向けたレクチン固定化スポンジ基材の開発
        久保 拓也; 加藤 誠也; 下田 麻子; 石川 良賀; 澤田 晋一; 佐々木 善浩; 秋吉 一成; 大塚 浩二
        分析化学, Dec. 2020
      • Identification of a dominant CD8(+) CTL epitope in the SARS-associated coronavirus 2 spike protein
        Daisuke Muraoka; Deng Situo; Shin-ichi Sawada; Kazunari Akiyoshi; Naozumi Harada; Hiroaki Ikeda
        VACCINE, Nov. 2020
      • Crosslinked nanogel-based porous hydrogel as a functional scaffold for tongue muscle regeneration
        Naoya Kinoshita; Yoshihiro Sasaki; Eriko Marukawa; Ryo Hirose; Shin-ichi Sawada; Hiroyuki Harada; Kazunari Akiyoshi
        JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Jul. 2020
      • Preparation of engineered extracellular vesicles with full-length functional PD-1 membrane proteins by baculovirus expression system
        Raga Ishikawa; Shosuke Yoshida; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2020
      • Synergistic anti-tumor efficacy by combination therapy of a self-assembled nanogel vaccine with an immune checkpoint anti-PD-1 antibody
        Risako Miura; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi
        RSC ADVANCES, Feb. 2020
      • Antigen Delivery to Antigen-Presenting Cells for Adaptive Immune Response by Self-Assembled Anionic Polysaccharide Nanogel Vaccines
        Risako Miura; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOMACROMOLECULES, Feb. 2020
      • Development of Lectin-immobilized Spongy Monoliths for Sub-classification of Exosome
        Takuya Kubo; Seiya Kato; Asako Shimoda; Raga Ishikawa; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Koji Otsuka
        BUNSEKI KAGAKU, 2020
      • Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering
        Shin-ichi Sawada; Yuko T. Sato; Riku Kawasaki; Jun-ichi Yasuoka; Ryosuke Mizuta; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOMATERIALS SCIENCE, Jan. 2020
      • Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array system
        Asako Shimoda; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        SCIENTIFIC REPORTS, Aug. 2019
      • Staphylococcus aureus-specific IgA antibody in milk suppresses the multiplication of S. aureus in infected bovine udder
        Yuya Nagasawa; Yoshio Kiku; Kazue Sugawara; Aya Hirose; Chiaki Kai; Nana Kitano; Toshihiko Takahashi; Tomonori Nochi; Hisashi Aso; Shin-ichi Sawada; Kazunari Akiyoshi; Tomohito Hayashi
        BMC VETERINARY RESEARCH, Aug. 2019
      • Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels
        Ryosuke Mizuta; Yoshihiro Sasaki; Riku Kawasaki; Kiyofumi Katagiri; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi
        BIOCONJUGATE CHEMISTRY, Aug. 2019, Peer-reviewed
      • Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery
        Shigeo Takeda; Tomoki Nishimura; Kaori Umezaki; Akiko Kubo; Michiyo Yanase; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOMATERIALS SCIENCE, Apr. 2019, Peer-reviewed
      • Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance
        Daisuke Muraoka; Naohiro Seo; Tae Hayashi; Yoshiro Tahara; Keisuke Fujii; Isao Tawara; Yoshihiro Miyahara; Kana Okamori; Hideo Yagita; Seiya Imoto; Rui Yamaguchi; Mitsuhiro Komura; Satoru Miyano; Masahiro Goto; Shin-ichi Sawada; Akira Asai; Hiroaki Ikeda; Kazunari Akiyoshi; Naozumi Harada; Hiroshi Shiku
        JOURNAL OF CLINICAL INVESTIGATION, Mar. 2019, Peer-reviewed
      • Structural effects and lymphocyte activation properties of self-assembled polysaccharide nanogels for effective antigen delivery
        Risako Miura; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        SCIENTIFIC REPORTS, Nov. 2018, Peer-reviewed
      • Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents
        Tatsuhiko Azegami; Yoshikazu Yuki; Kaori Hayashi; Akihito Hishikawa; Shin-ichi Sawada; Kazuya Ishige; Kazunari Akiyoshi; Hiroshi Kiyono; Hiroshi Itoh
        JOURNAL OF HYPERTENSION, Feb. 2018, Peer-reviewed
      • Self-Assembled Polypeptide Nanogels with Enzymatically Transformable Surface as a Small Interfering RNA Delivery Platform
        Tomoki Nishimura; Akina Yamada; Kaori Umezaki; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOMACROMOLECULES, Dec. 2017, Peer-reviewed
      • Nanogel-based nasal ghrelin vaccine prevents obesity.
        T Azegami; Y Yuki; S Sawada; M Mejima; K Ishige; K Akiyoshi; H Itoh; H Kiyono
        Mucosal immunology, Sep. 2017, Peer-reviewed
      • Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells
        Asako Shimoda; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2017, Peer-reviewed
      • 黄色ブドウ球菌死菌を抗原とした鼻腔粘膜感作による乳房炎防除効果
        長澤 裕哉; 菊 佳男; 菅原 和恵; 甲斐 千暁; 澤田 晋一; 秋吉 一成; 林 智人
        日本獣医学会学術集会講演要旨集, Aug. 2017
      • ナノゲル架橋マイクロスフェアの設計と機能
        秋吉 一成; 田原 義朗; 澤田 晋一; 向井 貞篤; 佐々木 善浩
        日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2017
      • Self-assembled nanogel of cholesterol-bearing xyloglucan as a drug delivery nanocarrier
        Shin-ichi Sawada; Hiroko Yukawa; Shigeo Takeda; Yoshihiro Sasaki; Kazunari Akiyoshi
        JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2017, Peer-reviewed
      • Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials
        Yoshiro Tahara; Mizuki Sakiyama; Shigeo Takeda; Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        LANGMUIR, Nov. 2016, Peer-reviewed
      • Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor
        Takahiro Arakawa; Yusuke Kuroki; Hiroki Nitta; Prem Chouhan; Koji Toma; Shin-ichi Sawada; Shuhei Takeuchi; Toshiaki Sekita; Kazunari Akiyoshi; Shunsuke Minakuchi; Kohji Mitsubayashi
        BIOSENSORS & BIOELECTRONICS, Oct. 2016, Peer-reviewed
      • Magnetically Guided Protein Transduction by Hybrid Nanogel Chaperones with Iron Oxide Nanoparticles
        Riku Kawasaki; Yoshihiro Sasaki; Kiyofumi Katagiri; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2016, Peer-reviewed
      • Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types
        Fumiyasu Momose; Naohiro Seo; Yasushi Akahori; Shin-ichi Sawada; Naozumi Harada; Toru Ogura; Kazunari Akiyoshi; Hiroshi Shiku
        PLOS ONE, Apr. 2016, Peer-reviewed
      • Advanced Artificial Extracellular Matrices Using Amphiphilic Nanogel-Cross-Linked Thin Films To Anchor Adhesion Proteins and Cytokines
        Yoshihide Hashimoto; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        ACS BIOMATERIALS SCIENCE & ENGINEERING, Mar. 2016, Peer-reviewed
      • Engineering hybrid exosomes by membrane fusion with liposomes.
        Yuko T Sato; Kaori Umezaki; Shinichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Naozumi Harada; Hiroshi Shiku; Kazunari Akiyoshi
        Scientific reports, 25 Feb. 2016, Peer-reviewed
      • Liposome chaperon in cell-free membrane protein synthesis: one-step preparation of KcsA-integrated liposomes and electrophysiological analysis by the planar bilayer method.
        M Ando; M Akiyama; D Okuno; M Hirano; T Ide; S Sawada; Y Sasaki; K Akiyoshi
        Biomaterials science, Feb. 2016, Peer-reviewed
      • Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA
        Asako Shimoda; Koji Ueda; Shin Nishiumi; Naoko Murata-Kamiya; Sada-atsu Mukai; Shin-ichi Sawada; Takeshi Azuma; Masanori Hatakeyama; Kazunari Akiyoshi
        SCIENTIFIC REPORTS, Jan. 2016, Peer-reviewed
      • Direct Measurement of Gaseous Formaldehyde from Food with a Fiber-Optic Biochemical Gas Sensor (Bio-sniffer)
        Koji Toma; Kumiko Miyajima; Shin-ichi Sawada; Takahiro Arakawa; Hiroyuki Kudo; Kazunari Akiyoshi; Kohji Mitsubayashi
        SENSORS AND MATERIALS, 2016, Peer-reviewed
      • A light sensitive self-assembled nanogel as a tecton for protein patterning materials
        Tomoki Nishimura; Masahiro Takara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed
      • Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system.
        Tatsuya Niwa; Yoshihiro Sasaki; Eri Uemura; Shugo Nakamura; Minato Akiyama; Mitsuru Ando; Shinichi Sawada; Sada-atu Mukai; Takuya Ueda; Hideki Taguchi; Kazunari Akiyoshi
        Scientific reports, 15 Dec. 2015, Peer-reviewed
      • Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques.
        Y Fukuyama; Y Yuki; Y Katakai; N Harada; H Takahashi; S Takeda; M Mejima; S Joo; S Kurokawa; S Sawada; H Shibata; E J Park; K Fujihashi; D E Briles; Y Yasutomi; H Tsukada; K Akiyoshi; H Kiyono
        Mucosal immunology, Sep. 2015, Peer-reviewed
      • Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems
        Yoshiro Tahara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        ADVANCED MATERIALS, Sep. 2015, Peer-reviewed
      • Glyco Star Polymers as Helical Multivalent Host and Biofunctional Nano-Platform
        Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi
        ACS MACRO LETTERS, Apr. 2015, Peer-reviewed
      • Protein nanogelation using vitamin B-6-bearing pullulan: effect of zinc ions
        Yuji Tsuchido; Yoshihiro Sasaki; Shin-ichi Sawada; Kazunari Akiyoshi
        POLYMER JOURNAL, Feb. 2015, Peer-reviewed
      • Effective CpG DNA delivery using amphiphilic cycloamylose nanogels.
        Y Tahara; J Yasuoka; S Sawada; Y Sasaki; K Akiyoshi
        Biomaterials science, Feb. 2015, Peer-reviewed
      • Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold
        Yoshihide Hashimoto; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        BIOMATERIALS, Jan. 2015, Peer-reviewed
      • 多糖ナノゲル架橋ハイブリッド材料の設計と機能
        秋吉 一成; 橋本 良秀; 澤田 晋一
        日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2015
      • A Fluorometric Biochemical Gas Sensor (Biosniffer) for Acetaldehyde Vapor Based on Catalytic Reaction of Aldehyde Dehydrogenase
        Yuki Suzuki; Ming Ye; Kumiko Miyajima; Takahiro Arakawa; Shin-ichi Sawada; Hiroyuki Kudo; Kazunari Akiyoshi; Kohji Mitsubayashi
        SENSORS AND MATERIALS, 2015
      • Amylose-Based Cationic Star Polymers for siRNA Delivery
        Tomoki Nishimura; Kaori Umezaki; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi
        BIOMED RESEARCH INTERNATIONAL, 2015, Peer-reviewed
      • Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
        Hidetaka Fujii; Masaharu Shin-Ya; Shigeo Takeda; Yoshihide Hashimoto; Sada-atsu Mukai; Shin-ichi Sawada; Tetsuya Adachi; Kazunari Akiyoshi; Tsuneharu Miki; Osam Mazda
        CANCER SCIENCE, Dec. 2014, Peer-reviewed
      • Nanogel-based pneumococcal surface protein A (PspA) intranasal vaccine: the effective delivery system of antigen across the nasal mucosal barrier
        Kong, I; A. Sato; S. Sato; T. Nochi; E. J. Park; Y. Yuki; H. Takahashi; S. Sawada; D. E. Briles; M. Yamamoto; K. Akiyoshi; H. Kiyono
        ALLERGY, Sep. 2014, Peer-reviewed
      • Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Antitumor Immunity
        Daisuke Muraoka; Naozumi Harada; Tae Hayashi; Yoshiro Tahara; Fumiyasu Momose; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi; Hiroshi Shiku
        ACS NANO, Sep. 2014, Peer-reviewed
      • 8pPSB-15 非平衡状態を利用したコロイド分散液の乾燥パターン制御(8pPSB 領域12ポスターセッション,領域12(ソフトマター物理・化学物理・生物物理))
        向井 貞篤; 橋本 良秀; 田原 義朗; 澤田 晋一; 秋吉 一成
        日本物理学会講演概要集, Jan. 2014
      • Proteo–liposome Engineering: Chaperoning Science for Preparationof Membrane Protein–reconstituted Liposomes
        Ando Mitsuru; Yoshida Shosuke; Sawada Shin-ichi; Akiyoshi Kazunari
        MEMBRANE, 2014
      • ナノゲル―リポソームハイブリッドゲルの設計とバイオ応用
        佐々木 善浩; 澤田 晋一; 秋吉 一成
        日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2014
      • Proteo–liposome Engineering: Chaperoning Science for Preparationof Membrane Protein–reconstituted Liposomes
        Ando Mitsuru; Yoshida Shosuke; Sawada Shin-ichi; Akiyoshi Kazunari
        MEMBRANE, 2014
      • 細胞外ベクシルの構造特性と機能制御 (特集 エクソソームとDDS)
        下田 麻子; 澤田 晋一; 秋吉 一成
        Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System, Jan. 2014
      • Nanogel bottom-up gel biomaterials for protein delivery: Photopolymerization of an acryloyl-modified polysaccharide nanogel macromonomer
        Yoshiro Tahara; Satoshi Kosuge; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        REACTIVE & FUNCTIONAL POLYMERS, Jul. 2013, Peer-reviewed
      • Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae.
        Il Gyu Kong; Ayuko Sato; Yoshikazu Yuki; Tomonori Nochi; Haruko Takahashi; Shinichi Sawada; Mio Mejima; Shiho Kurokawa; Kazunari Okada; Shintaro Sato; David E Briles; Jun Kunisawa; Yusuke Inoue; Masafumi Yamamoto; Kazunari Akiyoshi; Hiroshi Kiyono
        Infection and immunity, May 2013, Peer-reviewed
      • A polyion complex nanogel.
        Masafumi Takeo; Takeshi Mori; Takuro Niidome; Shinichi Sawada; Kazunari Akiyoshi; Yoshiki Katayama
        Journal of colloid and interface science, 15 Jan. 2013, Peer-reviewed
      • 多糖ナノボールの機能化とバイオ応用 (特別記念号)
        秋吉 一成; 澤田 晋一
        日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2013
      • シャペロン機能工学による新規バイオ材料の創製
        澤田 晋一; 秋吉 一成
        化学と工業 = Chemistry and chemical industry, Jan. 2013
      • 29aPS-22 多糖ナノゲル架橋ゲルの設計と構造特性(29aPS 領域12ポスターセッション,領域12(ソフトマター物理,化学物理,生物物理))
        向井 貞篤; 橋本 良秀; 田原 義朗; 澤田 晋一; 秋吉 一成
        日本物理学会講演概要集, Jan. 2013
      • 27aKP-6 ナノゲル架橋ゲルの構造と力学特性(ゲル,領域12(ソフトマター物理,化学物理,生物物理))
        向井 貞篤; 橋本 良秀; 田原 義朗; 澤田 晋一; 秋吉 一成
        日本物理学会講演概要集, Jan. 2013
      • Nanogel-based antigen-delivery system for nasal vaccines
        Yoshikazu Yuki; Tomonori Nochi; Il Gyu Kong; Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi; Hiroshi Kiyono
        BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 2013, Peer-reviewed
      • Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effective protein refolding
        Shigeo Takeda; Haruko Takahashi; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
        RSC ADVANCES, 2013, Peer-reviewed
      • Cyclodextrin triggered dimensional changes of polysaccharide nanogel integrated hydrogels at nanometer resolution
        Ming Gao; Sayaka Toita; Shin-ichi Sawada; Kazunari Akiyoshi; Bjorn Torger Stokke
        SOFT MATTER, 2013, Peer-reviewed
      • Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation
        Haruko Takahashi; Yoshiro Tahara; Shin-ichi Sawada; Kazunari Akiyoshi
        BIOMATERIALS SCIENCE, 2013, Peer-reviewed
      • Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery
        Asako Shimoda; Shin-ichi Sawada; Arihiro Kano; Atsushi Maruyama; Alexandre Moquin; Francoise M. Winnik; Kazunari Akiyoshi
        COLLOIDS AND SURFACES B-BIOINTERFACES, Nov. 2012, Peer-reviewed
      • Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups
        Yoshihiro Sasaki; Setsuko Yamane; Kei Kurosu; Shin-Ichi Sawada; Kazunari Akiyoshi
        POLYMERS, Jun. 2012, Peer-reviewed
      • Biodegradable nanogel-integrated hydrogels for sustained protein delivery
        Asako Shimoda; Yuka Yamamoto; Shin-ichi Sawada; Kazunari Akiyoshi
        MACROMOLECULAR RESEARCH, Mar. 2012, Peer-reviewed
      • Shear flow-induced nanotubulation of surface-immobilized liposomes
        Yurina Sekine; Keita Abe; Akitaka Shimizu; Yoshihiro Sasaki; Shin-ichi Sawada; Kazunari Akiyoshi
        RSC ADVANCES, 2012, Peer-reviewed
      • Artificial chaperone polysaccharide nanogels for protein delivery: a thermodynamic study of protein-nanogel interactions using fluorescence correlation spectroscopy.
        Yoshihiro Sasaki; Daisuke Iida; Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi
        Current drug discovery technologies, 01 Dec. 2011, Peer-reviewed
      • Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A(2)
        Sayaka Toita; Shin-ichi Sawada; Kazunari Akiyoshi
        JOURNAL OF CONTROLLED RELEASE, Oct. 2011, Peer-reviewed
      • The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate
        Kozo Watanabe; Yumiko Tsuchiya; Yoshinori Kawaguchi; Shin-ichi Sawada; Hirohito Ayame; Kazunari Akiyoshi; Takeshi Tsubata
        BIOMATERIALS, Sep. 2011
      • Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents
        MingXing Chu; Takayuki Shirai; Daishi Takahashi; Takahiro Arakawa; Hiroyuki Kudo; Kenji Sano; Shin-ichi Sawada; Kazuyoshi Yano; Yasuhiko Iwasaki; Kazunari Akiyoshi; Manabu Mochizuki; Kohji Mitsubayashi
        BIOMEDICAL MICRODEVICES, Aug. 2011
      • ナノゲル工学による新規DDSの開発
        澤田 晋一; 秋吉 一成
        膜, Jul. 2011
      • Cell Specific Peptide-Conjugated Polysaccharide Nanogels for Protein Delivery
        Asako Shimoda; Shin-ichi Sawada; Kazunari Akiyoshi
        MACROMOLECULAR BIOSCIENCE, Jul. 2011, Peer-reviewed
      • Amphiphilic Polysaccharide Nanogels as Artificial Chaperones in Cell-Free Protein Synthesis
        Yoshihiro Sasaki; Wakiko Asayama; Tatsuya Niwa; Shin-ichi Sawada; Takuya Ueda; Hideki Taguchi; Kazunari Akiyoshi
        MACROMOLECULAR BIOSCIENCE, Jun. 2011, Peer-reviewed
      • ナノゲルタンパク質デリバリーを用いた経鼻ワクチンの開発
        幸 義和; 清野 宏; 澤田 晋一; 秋吉 一成
        バイオマテリアル : 生体材料 : journal of Japanese Society for Biomaterials, Apr. 2011
      • Cyclodextrin-responsive nanogel as an artificial chaperone for horseradish peroxidase
        Shin-ichi Sawada; Yoshihiro Sasaki; Yuta Nomura; Kazunari Akiyoshi
        COLLOID AND POLYMER SCIENCE, Apr. 2011, Peer-reviewed
      • Metal Coordinative-crosslinked Polysaccharide Nanogels with Redox Sensitivity
        Yoshihiro Sasaki; Tai Hirakura; Shin-ichi Sawada; Kazunari Akiyoshi
        CHEMISTRY LETTERS, Feb. 2011, Peer-reviewed
      • Amphiphilic Polysaccharide Nanoballs: A New Building Block for Nanogel Biomedical Engineering and Artificial Chaperones
        Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi
        ACS NANO, Jan. 2011, Peer-reviewed
      • Construction of protein-crosslinked nanogels with vitamin B-6 bearing polysaccharide
        Yoshihiro Sasaki; Yuji Tsuchido; Shin-ichi Sawada; Kazunari Akiyoshi
        POLYMER CHEMISTRY, 2011, Peer-reviewed
      • Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment
        Ming Xing Chu; Kumiko Miyajima; Daishi Takahashi; Takahiro Arakawa; Kenji Sano; Shin-ichi Sawada; Hiroyuki Kudo; Yasuhiko Iwasaki; Kazunari Akiyoshi; Manabu Mochizuki; Kohji Mitsubayashi
        TALANTA, Jan. 2011
      • Polysaccharide nanogel-cyclodextrin system as an artificial chaperone for in vitro protein synthesis of green fluorescent protein
        Yoshihiro Sasaki; Yuta Nomura; Shin-ichi Sawada; Kazunari Akiyoshi
        POLYMER JOURNAL, Oct. 2010, Peer-reviewed
      • Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines
        Tomonori Nochi; Yoshikazu Yuki; Haruko Takahashi; Shin-ichi Sawada; Mio Mejima; Tomoko Kohda; Norihiro Harada; Il Gyu Kong; Ayuko Sato; Nobuhiro Kataoka; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Hideo Tsukada; Shunji Kozaki; Kazunari Akiyoshi; Hiroshi Kiyono
        NATURE MATERIALS, Jul. 2010
      • Nano-Encapsulation of Lipase by Self-Assembled Nanogels: Induction of High Enzyme Activity and Thermal Stabilization
        Shin-ichi Sawada; Kazunari Akiyoshi
        MACROMOLECULAR BIOSCIENCE, Apr. 2010, Peer-reviewed
      • ナノゲルエンジニアリングによるタンパク質DDSの開発
        秋吉 一成; 佐々木 善浩; 澤田 晋一
        生体材料工学研究所年報, Jan. 2010
      • ナノゲル工学による新規DDSの設計
        澤田 晋一; 秋吉 一成
        薬剤学 = The archives of practical pharmacy, Jan. 2010
      • Raspberry-like assembly of cross-linked nanogels for protein delivery
        Urara Hasegawa; Shin-ichi Sawada; Takeshi Shimizu; Tsunao Kishida; Eigo Otsuji; Osam Mazda; Kazunari Akiyoshi
        JOURNAL OF CONTROLLED RELEASE, Dec. 2009
      • Self-Assembled Nanogel of Hydrophobized Dendritic Dextrin for Protein Delivery
        Yayoi Ozawa; Shin-ichi Sawada; Nobuyuki Morimoto; Kazunari Akiyoshi
        MACROMOLECULAR BIOSCIENCE, Jul. 2009
      • Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone
        Nobuyuki Morimoto; Junko Tamada; Shin-ichi Sawada; Naohiko Shimada; Arihiro Kano; Atsushi Maruyama; Kazunari Akiyoshi
        CHEMISTRY LETTERS, May 2009
      • Interfacing biomembrane mimetic polymer surfaces with living cells - Surface modification for reliable bioartificial liver
        Yasuhiko Iwasaki; Utae Takami; Shin-Ichi Sawada; Kazunari Akiyoshi
        APPLIED SURFACE SCIENCE, Nov. 2008
      • Comparison of refolding activities between nanogel artificial chaperone and GroEL systems
        Wakiko Asayama; Shin-Ichi Sawada; Hideki Taguchi; Kazunari Akiyoshi
        INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Apr. 2008
      • Stress response of adherent cells on a polymer blend surface composed of a segmented polyurethane and MPC copolymers
        Shin-Ichi Sawada; Yasuhiko Iwasaki; Nobuo Nakabayashi; Kazuhiko Ishihara
        JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Dec. 2006
      • Inhibition of the formation of amyloid beta-protein fibrils using biocompatible nanogels as artificial chaperones
        Keisuke Ikeda; Takuma Okada; Shin-ichi Sawada; Kazunari Akiyoshi; Katsumi Matsuzaki
        FEBS LETTERS, Dec. 2006, Peer-reviewed
      • Heat shock protein-like activity of a nanogel artificial chaperone for citrate synthase
        Shin-Ichi Sawada; Yuta Nomura; Yasuhiro Aoyama; Kazunari Akiyoshi
        JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, Nov. 2006
      • Participant's Report on the 1st Integrated Meeting on Thermal Physiology and Pharmacology of Thermoregulation (PPTR2004)
        Sawada Shinichi
        JAPANESE JOURNAL OF BIOMETEOROLOGY, 2004
      • Suppression of the inflammatory response from adherent cells on phospholipid polymers
        S Sawada; S Sakaki; Y Iwasaki; N Nakabayashi; K Ishihara
        JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Mar. 2003
      • Reduction of surface-induced inflammatory reaction on PLGA/MPC polymer blend
        Y Iwasaki; S Sawada; K Ishihara; G Khang; HB Lee
        BIOMATERIALS, Sep. 2002
      • The effect of the chemical structure of the phospholipid polymer on fibronectin adsorption and fibroblast adhesion on the gradient phospholipid surface
        Y Iwasaki; S Sawada; N Nakabayashi; G Khang; HB Lee; K Ishihara
        BIOMATERIALS, Nov. 1999

      Misc.

      • ナノ粒子による脂質膜の構造制御とバイオ機能
        佐々木善浩; 名倉百華; 井上文仁; 氏平勇樹; 澤田晋一; 向井貞篤; 秋吉一成
        高分子学会予稿集(CD-ROM), 29 Aug. 2018
      • 機能性膜タンパク質を搭載した新規ハイブリッド細胞外ベシクルの開発
        石川良賀; 吉田昭介; 澤田晋一; 向井貞篤; 佐々木善浩; 秋吉一成
        高分子学会予稿集(CD-ROM), 29 Aug. 2018
      • 音響波によるナノゲル架橋ゲルのマイクロ構造制御とその物性評価
        角田千里; 向井貞篤; 澤田晋一; 佐々木善浩; 秋吉一成
        高分子学会予稿集(CD-ROM), 29 Aug. 2018
      • 免疫チェックポイントタンパク質を発現した細胞外ベシクルの構築と機能
        石川良賀; 吉田昭介; 澤田晋一; 澤田晋一; 向井貞篤; 向井貞篤; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 08 May 2018
      • 音響波によるナノゲル架橋ゲルのマイクロ構造制御とその物性評価
        角田千里; 向井貞篤; 向井貞篤; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 08 May 2018
      • 生分解性ナノゲル架橋ポーラスゲル材料の設計と機能評価
        廣瀬諒; 澤田晋一; 澤田晋一; 向井貞篤; 向井貞篤; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 08 May 2018
      • 両親媒性グラフト型糖鎖からなるポリマーベシクルの設計と機能
        西村智貴; 西村智貴; SHEN Shishi; 澤田晋一; 澤田晋一; 向井貞篤; 向井貞篤; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 08 May 2018
      • 両親媒性多糖ナノゲルによるハイブリッド細胞スフェロイドの構築
        久保博嵩; 向井貞篤; 向井貞篤; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 08 May 2018
      • 機能性自己組織化多糖ナノゲルの設計とバイオメディカル応用
        澤田晋一; 澤田晋一; 田原義朗; 向井貞篤; 向井貞篤; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 06 Sep. 2017
      • 平衡過程を利したナノゲル架橋マイクロ構造の形成と物性評価
        向井貞篤; 向井貞篤; 藤本達也; 角田千里; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成
        高分子学会予稿集(CD-ROM), 06 Sep. 2017
      • グライコテクトニクスによる新規バイオ材料の設計と機能
        秋吉 一成; 西村 智貴; 澤田 晋一
        日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, 2016
      • Control of in vivo spatiotemporal dynamics of antigen and adjuvant by a delivery system CHP nanogel markedly improves the immunogenicity and antitumor efficacy of long peptide cancer vaccine.
        Daisuke Muraoka; Naozumi Harada; Tae Hayashi; Shin-ichi Sawada; Kazunari Akiyoshi; Hiroshi Shiku
        CANCER RESEARCH, Jan. 2013
      • 新規多糖ナノゲルの設計とバイオ応用
        秋吉 一成; 澤田 晋一
        日本化学繊維研究所講演集, Mar. 2012
      • Preparation of protein-crosslinked nanogels with pyridoxal-bearing polysaccharide for potential biomedical applications
        Yoshihiro Sasaki; Yuji Tsuchido; Shin-ichi Sawada; Kazunari Akiyoshi
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2012
      • Utilization of cell structures extracellular vesicles secreted from a cell: function and application of exosomes
        澤田晋一; 澤田晋一; 佐藤祐子; 佐藤祐子; 秋吉一成; 秋吉一成
        バイオマテリアル, 2012
      • 無細胞タンパク質発現系によるプロテオリポソームの構築と機能
        安岡潤一; 安岡潤一; 澤田晋一; 由井伸彦; 秋吉一成; 秋吉一成; 秋吉一成
        生化学, 2011
      • Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines (vol 9, pg 572, 2010)
        Tomonori Nochi; Yoshikazu Yuki; Haruko Takahashi; Shin-ichi Sawada; Mio Mejima; Tomoko Kohda; Norihiro Harada; Il Gyu Kong; Ayuko Sato; Nobuhiro Kataoka; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Hideo Tsukada; Shunji Kozaki; Kazunari Akiyoshi; Hiroshi Kiyono
        NATURE MATERIALS, Aug. 2010
      • Glycogen nano-ball for polysaccharide nanogel engineering
        Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2010
      • Nanogel antigen delivery system for adjuvant-free intranasal vaccines
        Tomonori Nochi; Yoshikazu Yuki; Haruko Takahashi; Shinichi Sawada; Mio Mejima; Tomoko Kohda; Norihiro Harada; Nobuhiro Kataoka; Il Gyu Kong; Ayuko Sato; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Hideo Tsukada; Shunji Kozaki; Kazunari Akiyoshi; Hiroshi Kiyono
        JOURNAL OF IMMUNOLOGY, Apr. 2010
      • POLY 421-Nanogel artificial chaperone: Refolding and cell-free protein synthesis of GFP
        Wakiko Asayama; Yuta Nomura; Shin-ichi Sawada; Nobuyuki Morimoto; Kazunari Akiyoshi
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006
      • Thermoregulatory characteristics and thermal loads in cold work environments.
        SAWADA Shin-ichi
        産業衛生学雑誌 = Journal of occupational health, 10 Mar. 2001
      • Analysis of thermoregulatory responses of resting of older men under different ambient temperature conditions : with special reference to the skin temperature distribution and thermoregulatory behaviour
        SAWADA Shin-ichi
        Symposium on Man-Thermal Environment System, 01 Nov. 1989
      • OBSERVATION OF THERMOREGULATORY CHARACTERISTICS IN MIDDLE-AGED WORKERS
        SAWADA Shin-ichi
        Symposium on Man-Thermal Environment System, 09 Dec. 1988
      • CHARACTERISTICS OF THERMOREGULATORY RESPONSES IN THE SPONTANEOUSLY HYPERTENSIVE RAT(SHR)
        SAWADA Shin-ichi
        Symposium on Man-Thermal Environment System, 04 Dec. 1987

      Presentations

      • The function control by construction of exosome hybrid
        澤田晋一
        The 5th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan, 11 Jul. 2019, Invited

      External funds: Kakenhi

      • 核酸クリップナノゲルのシャペロン機能
        Grant-in-Aid for Scientific Research (C)
        Basic Section 90120:Biomaterials-related
        Kyoto University
        澤田 晋一
        From 01 Apr. 2018, To 31 Mar. 2021, Granted
        自己組織化;核酸;刺激応答性;ナノゲル;タンパク質;シャペロン
      • Design and biomaterial application of nucleic acid-clipping nanogel
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Shin-ichi Sawada
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        ナノゲル;多糖;オリゴ核酸;架橋化核酸;二重鎖形成;自己組織化;核酸;温度応答性;刺激応答性;疎水化多糖
      • Development of novel technology for prevention of mastitis using nanotechnology
        Grant-in-Aid for Challenging Exploratory Research
        Tohoku University
        Tomonori Nochi
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        黄色ブドウ球菌;乳房炎;抗体;増殖阻害;in vitro;ウシポリクローナル抗体;ナノテクノロジー
      • Functionalization and DDS application of extracellular vesicles
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Shin-ichi SAWADA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        エクストラセルラーベシクル;エクソソーム;両親媒性高分子;疎水化多糖;カチオン性分子
      • Development of cancer-controlling vector conversion techniques using nano-DDS
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        Kazunari AKIYOSHI
        From 01 Apr. 2010, To 31 Mar. 2015, Project Closed
        ドラッグデリバリーシステム;がん治療;ナノゲル;ワクチン;エクソソーム;siRNA;腫瘍微小環境;細胞特異性;RGDペプチド;抗体;サイトカイン;タンパク質デリバリー;核酸デリバリー;エンドサイトーシス;遺伝子導入;シャペロン機能
      • Development ofnew nanogel-based drug delivery systems
        Grant-in-Aid for Scientific Research (A)
        Kyoto University;Tokyo Medical and Dental University
        Kazunari AKIYOSHI
        From 08 Apr. 2008, To 31 Mar. 2013, Project Closed
        ナノゲル;ヒドロゲル;タンパク質;ドラッグデリバリー;細胞機能;多糖;タンパク質デリバリー;核酸デリバリー;反応性ナノゲル;骨形成;ビタミンB6;リポソーム;Schiff塩基;ドラッグデリバリーシステム;再生医療用足場材料;ナノゲル架橋微粒子;プロスタグランジンE1;骨再生;アパタイト;有機-無機ハイブリッド
      • 機能性膜を自動生成する人工細胞モデルの構成と評価
        Grant-in-Aid for Scientific Research on Priority Areas
        Science and Engineering
        Kyoto University
        野村 慎一郎
        Project Closed
        リポソーム;膜タンパク質;人工細胞モデル;人工分子シャペロン;無細胞発現
      • Development of nanocarrier for cancer immunotherapy
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Medical and Dental University
        Kazunari AKIYOSHI
        Project Closed
        癌免疫;サイトカイン;ナノゲル;遺伝子デリバリー;分子シャペロン;カチオン性多糖;タンパク質ワクチン;トランスフェクション;サイトカン;潰伝子デリバリー
      • Design of ion complex nanogels
        Grant-in-Aid for Young Scientists (B)
        Tokyo Medical and Dental University
        Shinichi SAWADA
        Project Closed
        ナノゲル;多糖;イオン性相互作用;動的高分子ナノ組織体;イオンコンプレックス;オリゴペプチド;イオンコンプレックスナノゲル;クリック反応;オリゴリシン;オリゴグルタミン酸;プルラン
      • 癌免疫治療のための新規ナノゲルキャリアの開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Medical and Dental University
        秋吉 一成
        Project Closed
        癌免疫;ナノゲル;インターロイキン12;DDS;癌抗原;癌タンパク質ワクチン;癌免疫治療;サイトカイン;IL12
      list
        Last Updated :2022/05/14

        Education

        Teaching subject(s)

        • From Apr. 2011, To Mar. 2012
          生体機能高分子
          Spring, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2013, To Mar. 2014
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2014, To Mar. 2015
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2018, To Mar. 2019
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2020, To Mar. 2021
          Polymer Synthesis
          Spring, 工学研究科
        • From Apr. 2021, To Mar. 2022
          Polymer Synthesis
          Spring, 工学研究科

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