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Nagayasu, Kazuki

Graduate School of Pharmaceutical Sciences, Division of Biomedical Sciences Assistant Professor

Nagayasu, Kazuki
list
    Last Updated :2022/08/09

    Basic Information

    Faculty

    • 薬学部

    Professional Memberships

    • 北米神経科学会
    • THE JAPAN NEUROSCIENCE SOCIETY
    • THE PHARMACEUTICAL SOCIETY OF JAPAN
    • THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
    • THE JAPANESE PHARMACOLOGICAL SOCIETY

    Academic Degree

    • 修士（薬学）(京都大学)
    • 博士（薬学）(京都大学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院薬学研究科修士課程生命薬科学専攻, 修了
    • 京都大学, 大学院薬学研究科博士後期課程生命薬科学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 薬学部総合薬学科, 卒業

    High School

    • High School

      甲陽学院高等学校

    Research History

    • From Nov. 2017, To Present
      Kyoto University, 薬学研究科, 助教
    • From Apr. 2016, To Oct. 2017
      Kyoto University, 薬学研究科, 特定助教
    • From Jun. 2013, To Mar. 2016
      大阪大学大学院, 薬学研究科附属創薬センター iPS脳神経毒性プロジェクト, 特任助教
    • From Apr. 2013, To May 2013
      日本学術振興会, 特別研究員（PD）
    • From Apr. 2012, To Mar. 2013
      日本学術振興会, 特別研究員（DC）
    • Osaka University School of Pharmaceutical Sciences, 特任助教

    Profile

    • Profile

      ・人間の心と薬物依存から中枢神経薬理の道に入り、現在は、5-HTが脳で何をしているのか、精神疾患およびその治療過程において何をしているのかに興味があります。なぜ5-HTのようなトランスミッターがヒト（以外もですが）にとって必要あるいは都合が良かったのか。


      ・2008年京都大学薬学部卒業、2013年京都大学大学院薬学研究科博士課程修了

    ID,URL

    researchmap URL

    list
      Last Updated :2022/08/09

      Research

      Research Areas

      • Life sciences, Pharmacology

      Papers

      • Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes.
        Hiroki Nakajima; Sayaka Fujita; Masashi Kakae; Kazuki Nagayasu; Masatsugu Oh-Hora; Hisashi Shirakawa; Shuji Kaneko
        Glia, Sep. 2022
      • Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling.
        Kaito Takayama; Shota Tobori; Chihiro Andoh; Masashi Kakae; Masako Hagiwara; Kazuki Nagayasu; Hisashi Shirakawa; Yukio Ago; Shuji Kaneko
        Biological & pharmaceutical bulletin, 2022
      • An essential role of the median raphe serotonin neurons projecting to the interpeduncular nucleus in reward processing.
        Hiroyuki Kawai; Nagai Yuma; Koda Masashi; Nishitani Naoya; Nagayasu Kazuki; Shirakawa Hisashi; Kaneko Shuji
        Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021
      • Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
        Misaki Niu; Atsushi Kasai; Masato Tanuma; Kaoru Seiriki; Hisato Igarashi; Takahiro Kuwaki; Kazuki Nagayasu; Keita Miyaji; Hiroki Ueno; Wataru Tanabe; Kei Seo; Rei Yokoyama; Jin Ohkubo; Yukio Ago; Misuzu Hayashida; Ken-Ichi Inoue; Masahiko Takada; Shun Yamaguchi; Takanobu Nakazawa; Shuji Kaneko; Hiroyuki Okuno; Akihiro Yamanaka; Hitoshi Hashimoto
        Science advances, 18 Mar. 2022
      • A selective serotonin reuptake inhibitor ameliorates obsessive–compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex
        Hikari Hatakama; Nozomi Asaoka; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        Neuropharmacology, Mar. 2022
      • Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.
        Kana Yamamoto; Toshihiko Kuriu; Kensuke Matsumura; Kazuki Nagayasu; Yoshinori Tsurusaki; Noriko Miyake; Hidenaga Yamamori; Yuka Yasuda; Michiko Fujimoto; Mikiya Fujiwara; Masayuki Baba; Kohei Kitagawa; Tomoya Takemoto; Nanaka Gotoda-Nishimura; Tomohiro Takada; Kaoru Seiriki; Atsuko Hayata-Takano; Atsushi Kasai; Yukio Ago; Satoshi Kida; Kazuhiro Takuma; Fumihito Ono; Naomichi Matsumoto; Ryota Hashimoto; Hitoshi Hashimoto; Takanobu Nakazawa
        Translational psychiatry, 25 Oct. 2021
      • Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease.
        Soni Siswanto; Hiroki Yamamoto; Haruka Furuta; Mone Kobayashi; Takuya Nagashima; Gen Kayanuma; Kazuki Nagayasu; Yumiko Imai; Shuji Kaneko
        Frontiers in pharmacology, 2021
      • Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.
        Tomoya Takemoto; Masayuki Baba; Kazumasa Yokoyama; Kohei Kitagawa; Kazuki Nagayasu; Yukio Ago; Kaoru Seiriki; Atsuko Hayata-Takano; Atsushi Kasai; Daisuke Mori; Norio Ozaki; Kazuhiro Takuma; Ryota Hashimoto; Hitoshi Hashimoto; Takanobu Nakazawa
        Molecular brain, 28 Mar. 2022
      • MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations.
        Shota Tobori; Haruka Hiyama; Takahito Miyake; Yuichi Yano; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Yasuo Mori; Shuji Kaneko
        Journal of pharmacological sciences, Aug. 2021
      • 社会的敗北ストレスによるセロトニンニューロンの変化とその役割について
        永安一樹; 金子周司
        Clinical Neuroscience, Jun. 2021, Invited, Lead author, Corresponding author
      • Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial dyskinesia.
        Koki Nagaoka; Takuya Nagashima; Nozomi Asaoka; Hiroki Yamamoto; Chihiro Toda; Gen Kayanuma; Soni Siswanto; Yasuhiro Funahashi; Keisuke Kuroda; Kozo Kaibuchi; Yasuo Mori; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        JCI insight, 24 May 2021
      • Pronociceptive Roles of Schwann Cell-Derived Galectin-3 in Taxane-Induced Peripheral Neuropathy.
        Madoka Koyanagi; Satoshi Imai; Mayuna Matsumoto; Yoko Iguma; Nobuko Kawaguchi-Sakita; Takeshi Kotake; Yuki Iwamitsu; Mpumelelo Ntogwa; Ren Hiraiwa; Kazuki Nagayasu; Mamiko Saigo; Takashi Ogihara; Atsushi Yonezawa; Tomohiro Omura; Shunsaku Nakagawa; Takayuki Nakagawa; Kazuo Matsubara
        Cancer research, 15 Apr. 2021
      • Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder.
        Kohei Kitagawa; Kensuke Matsumura; Masayuki Baba; Momoka Kondo; Tomoya Takemoto; Kazuki Nagayasu; Yukio Ago; Kaoru Seiriki; Atsuko Hayata-Takano; Atsushi Kasai; Kazuhiro Takuma; Ryota Hashimoto; Hitoshi Hashimoto; Takanobu Nakazawa
        Molecular brain, 16 Mar. 2021
      • Prediction of pharmacological activities from chemical structures with graph convolutional neural networks.
        Miyuki Sakai; Kazuki Nagayasu; Norihiro Shibui; Chihiro Andoh; Kaito Takayama; Hisashi Shirakawa; Shuji Kaneko
        Scientific reports, 12 Jan. 2021
      • Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions.
        Kana Ohashi; Koji Shibasaki; Hayaki Nakazawa; Ryotaro Kunimasa; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        Biological & pharmaceutical bulletin, 2021
      • Transient receptor potential vanilloid 4 agonist GSK1016790A improves neurological outcomes after intracerebral hemorrhage in mice.
        Yasunori Asao; Shota Tobori; Masashi Kakae; Kazuki Nagayasu; Koji Shibasaki; Hisashi Shirakawa; Shuji Kaneko
        Biochemical and biophysical research communications, 27 Aug. 2020
      • Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.
        Shintaro Wada; Junko Yanagida; Hitoki Sasase; Tong Zhang; Xueting Li; Hironori Kamii; Masaki Domoto; Satoshi Deyama; Eiichi Hinoi; Akihiro Yamanaka; Naoya Nishitani; Kazuki Nagayasu; Shuji Kaneko; Masabumi Minami; Katsuyuki Kaneda
        Neuropharmacology, Apr. 2020, Peer-reviewed
      • The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion.
        Yuma Nagai; Kaito Takayama; Naoya Nishitani; Chihiro Andoh; Masashi Koda; Hisashi Shirakawa; Takayuki Nakagawa; Kazuki Nagayasu; Akihiro Yamanaka; Shuji Kaneko
        International journal of molecular sciences, 21 Mar. 2020, Peer-reviewed
      • 光遺伝学的計測と操作を用いた報酬関連行動における正中縫線核セロトニン神経の役割の解明
        河合 洋幸; 永井 佑茉; 好田 匡志; 永安 一樹; 白川 久志; 金子 周司
        日本薬学会年会要旨集, Mar. 2020
      • 慢性脳低灌流による認知機能低下への反応性アストロサイトの関与
        抱 将史; 森嶋 美沙; 戸堀 翔太; 永安 一樹; 白川 久志; 金子 周司
        日本薬学会年会要旨集, Mar. 2020
      • 急性社会的敗北ストレス負荷によるコカイン欲求行動増強におけるノルアドレナリンおよびドパミン伝達の役割
        李 雪てい; 柳田 淳子; 初 金玲; 本野 芽衣; 出山 諭司; 山中 章弘; 西谷 直也; 永安 一樹; 金子 周司; 金田 勝幸
        日本薬学会年会要旨集, Mar. 2020
      • 急性社会的敗北ストレス負荷によるコカイン欲求行動増強におけるノルアドレナリンおよびドパミン伝達の役割
        李 雪てい; 柳田 淳子; 初 金玲; 本野 芽衣; 出山 諭司; 山中 章弘; 西谷 直也; 永安 一樹; 金子 周司; 金田 勝幸
        日本薬学会年会要旨集, Mar. 2020
      • Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
        Kensuke Matsumura; Kaoru Seiriki; Shota Okada; Masashi Nagase; Shinya Ayabe; Ikuko Yamada; Tamio Furuse; Hirotoshi Shibuya; Yuka Yasuda; Hidenaga Yamamori; Michiko Fujimoto; Kazuki Nagayasu; Kana Yamamoto; Kohei Kitagawa; Hiroki Miura; Nanaka Gotoda-Nishimura; Hisato Igarashi; Misuzu Hayashida; Masayuki Baba; Momoka Kondo; Shigeru Hasebe; Kosei Ueshima; Atsushi Kasai; Yukio Ago; Atsuko Hayata-Takano; Norihito Shintani; Tokuichi Iguchi; Makoto Sato; Shun Yamaguchi; Masaru Tamura; Shigeharu Wakana; Atsushi Yoshiki; Ayako M Watabe; Hideyuki Okano; Kazuhiro Takuma; Ryota Hashimoto; Hitoshi Hashimoto; Takanobu Nakazawa
        Nature communications, 26 Feb. 2020, Peer-reviewed
      • Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.
        Tong Zhang; Junko Yanagida; Hironori Kamii; Shintaro Wada; Masaki Domoto; Hitoki Sasase; Satoshi Deyama; Takeshi Takarada; Eiichi Hinoi; Kenji Sakimura; Akihiro Yamanaka; Takashi Maejima; Michihiro Mieda; Takeshi Sakurai; Naoya Nishitani; Kazuki Nagayasu; Shuji Kaneko; Masabumi Minami; Katsuyuki Kaneda
        Addiction biology, Jan. 2020, Peer-reviewed
      • Myelin Oligodendrocyte Glycoprotein 35-55 (MOG 35-55)-induced Experimental Autoimmune Encephalomyelitis: A Model of Chronic Multiple Sclerosis.
        Sakie Miyamura; Nagisa Matsuo; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        Bio-protocol, 20 Dec. 2019
      • Autism-associated protein kinase D2 regulates embryonic cortical neuron development.
        Kensuke Matsumura; Masayuki Baba; Kazuki Nagayasu; Kana Yamamoto; Momoka Kondo; Kohei Kitagawa; Tomoya Takemoto; Kaoru Seiriki; Atsushi Kasai; Yukio Ago; Atsuko Hayata-Takano; Norihito Shintani; Toshihiko Kuriu; Tokuichi Iguchi; Makoto Sato; Kazuhiro Takuma; Ryota Hashimoto; Hitoshi Hashimoto; Takanobu Nakazawa
        Biochemical and biophysical research communications, 12 Nov. 2019, Peer-reviewed
      • Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.
        Masayuki Baba; Kazumasa Yokoyama; Kaoru Seiriki; Yuichiro Naka; Kensuke Matsumura; Momoka Kondo; Kana Yamamoto; Misuzu Hayashida; Atsushi Kasai; Yukio Ago; Kazuki Nagayasu; Atsuko Hayata-Takano; Akinori Takahashi; Shun Yamaguchi; Daisuke Mori; Norio Ozaki; Tadashi Yamamoto; Kazuhiro Takuma; Ryota Hashimoto; Hitoshi Hashimoto; Takanobu Nakazawa
        Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Nov. 2019, Peer-reviewed
      • Identification of neuron-type specific promoters in monkey genome and their functional validation in mice.
        Yuma Nagai; Naoya Nishitani; Masaharu Yasuda; Yasumasa Ueda; Yuto Fukui; Chihiro Andoh; Hisashi Shirakawa; Takayuki Nakagawa; Ken-Ichi Inoue; Kazuki Nagayasu; Sergey Kasparov; Kae Nakamura; Shuji Kaneko
        Biochemical and biophysical research communications, 22 Oct. 2019, Peer-reviewed
      • CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice.
        Naoya Nishitani; Yu Ohmura; Kazuki Nagayasu; Norihiro Shibui; Shuji Kaneko; Akiko Ohashi; Takayuki Yoshida; Akihiro Yamanaka; Mitsuhiro Yoshioka
        Brain research, 15 Sep. 2019, Peer-reviewed
      • Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model.
        Masashi Kakae; Shota Tobori; Misa Morishima; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        Biochemical and biophysical research communications, 05 Jul. 2019, Peer-reviewed
      • Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.
        Masashi Kakae; Jun Miyanohara; Misa Morishima; Kazuki Nagayasu; Yasuo Mori; Hisashi Shirakawa; Shuji Kaneko
        Neuroscience, 01 Jun. 2019, Peer-reviewed
      • Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.
        Atsuko Hayata-Takano; Toshihiko Kamo; Harui Kijima; Kaoru Seiriki; Katsuya Ogata; Yukio Ago; Takanobu Nakazawa; Yusuke Shintani; Kosuke Higashino; Kazuki Nagayasu; Norihito Shintani; Atsushi Kasai; James A Waschek; Hitoshi Hashimoto
        The Journal of neuroscience : the official journal of the Society for Neuroscience, 29 May 2019, Peer-reviewed
      • Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.
        Naoya Nishitani; Kazuki Nagayasu; Nozomi Asaoka; Mayumi Yamashiro; Chihiro Andoh; Yuma Nagai; Haruko Kinoshita; Hiroyuki Kawai; Norihiro Shibui; Beihui Liu; James Hewinson; Hisashi Shirakawa; Takayuki Nakagawa; Hitoshi Hashimoto; Sergey Kasparov; Shuji Kaneko
        Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Mar. 2019, Peer-reviewed
      • TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.
        Chihiro Andoh; Naoya Nishitani; Emina Hashimoto; Yuma Nagai; Keizo Takao; Tsuyoshi Miyakawa; Takayuki Nakagawa; Yasuo Mori; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        Brain research, 01 Feb. 2019, Peer-reviewed
      • An Adenosine A2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis.
        Asaoka N; Nishitani N; Kinoshita H; Nagai Y; Hatakama H; Nagayasu K; Shirakawa H; Nakagawa T; Kaneko S
        eNeuro, Jan. 2019, Peer-reviewed
      • [The biological basis and application of lentiviral vector and adeno-associated viral vector in pharmacological research].
        Kazuki Nagayasu
        Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2019, Peer-reviewed
      • The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain.
        Koichi Isami; Satoshi Imai; Asami Sukeishi; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        Brain, behavior, and immunity, Nov. 2018, Peer-reviewed
      • TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
        Masato Tsutsui; Ryo Hirase; Sakie Miyamura; Kazuki Nagayasu; Takayuki Nakagawa; Yasuo Mori; Hisashi Shirakawa; Shuji Kaneko
        The Journal of neuroscience : the official journal of the Society for Neuroscience, 26 Sep. 2018, Peer-reviewed
      • Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons.
        Hiroyuki Kawai; Nozomi Asaoka; Takahito Miyake; Kazuki Nagayasu; Takayuki Nakagawa; Hisashi Shirakawa; Shuji Kaneko
        Journal of pharmacological sciences, Jul. 2018, Peer-reviewed
      • TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.
        Kana Ohashi; Ayane Deyashiki; Takahito Miyake; Kazuki Nagayasu; Koji Shibasaki; Hisashi Shirakawa; Shuji Kaneko
        Pflugers Archiv : European journal of physiology, May 2018, Peer-reviewed
      • TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion.
        Miyanohara J; Kakae M; Nagayasu K; Nakagawa T; Mori Y; Arai K; Shirakawa H; Kaneko S
        The Journal of neuroscience : the official journal of the Society for Neuroscience, Apr. 2018, Peer-reviewed
      • 多角的視点から膜タンパク質機能とその創薬への応用を探究する 強迫性障害モデル動物の作成と治療ターゲット探索
        浅岡 希美; 西谷 直也; 木ノ下 晴子; 永井 佑茉; 永安 一樹; 白川 久志; 中川 貴之; 金子 周司
        日本薬学会年会要旨集, Mar. 2018
      • Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus.
        Haruko Kinoshita; Naoya Nishitani; Yuma Nagai; Chihiro Andoh; Nozomi Asaoka; Hiroyuki Kawai; Norihiro Shibui; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        The international journal of neuropsychopharmacology, 01 Mar. 2018, Peer-reviewed
      • Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.
        Tong Zhang; Satoshi Deyama; Masaki Domoto; Shintaro Wada; Junko Yanagida; Hitoki Sasase; Eiichi Hinoi; Naoya Nishitani; Kazuki Nagayasu; Shuji Kaneko; Katsuyuki Kaneda
        Biological & pharmaceutical bulletin, 2018, Peer-reviewed
      • TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy.
        Hiyama H; Yano Y; So K; Imai S; Nagayasu K; Shirakawa H; Nakagawa T; Kaneko S
        Molecular pain, Jan. 2018, Peer-reviewed
      • Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages
        Asami Sukeishi; Koichi Isami; Haruka Hiyama; Satoshi Imai; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        MOLECULAR PAIN, Nov. 2017, Peer-reviewed
      • Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin
        Takahito Miyake; Saki Nakamura; Zhao Meng; Satoshi Hamano; Keisuke Inoue; Tomohiro Numata; Nobuaki Takahashi; Kazuki Nagayasu; Hisashi Shirakawa; Yasuo Mori; Takayuki Nakagawa; Shuji Kaneko
        FRONTIERS IN PHYSIOLOGY, Nov. 2017, Peer-reviewed
      • Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide
        Shohei Oyama; Koji Dogishi; Mizuki Kodera; Masashi Kakae; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        FRONTIERS IN PHYSIOLOGY, Nov. 2017, Peer-reviewed
      • Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABA(B) receptor-mediated inhibition of L-type calcium channels
        Nozomi Asaoka; Naoya Nishitani; Haruko Kinoshita; Hiroyuki Kawai; Norihiro Shibui; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        SCIENTIFIC REPORTS, Oct. 2017, Peer-reviewed
      • ラットにおいて光遺伝学的操作を可能とする神経種特異的ウイルスベクターを用いたセロトニン神経機能の解析
        西谷 直也; 浅岡 希美; 木ノ下 晴子; 河合 洋幸; 澁井 紀宏; 永安 一樹; 白川 久志; 中川 貴之; 金子 周司
        日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017
      • Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes
        Hisashi Shirakawa; Rumi Katsumoto; Shota Iida; Takahito Miyake; Takuya Higuchi; Takuya Nagashima; Kazuki Nagayasu; Takayuki Nakagawa; Shuji Kaneko
        GLIA, Jun. 2017, Peer-reviewed
      • High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates
        Kaoru Seiriki; Atsushi Kasai; Takeshi Hashimoto; Wiebke Schulze; Misaki Niu; Shun Yamaguchi; Takanobu Nakazawa; Ken-ichi Inoue; Shiori Uezono; Masahiko Takada; Yuichiro Naka; Hisato Igarashi; Masato Tanuma; James A. Waschek; Yukio Ago; Kenji F. Tanaka; Atsuko Hayata-Takano; Kazuki Nagayasu; Norihito Shintani; Ryota Hashimoto; Yasuto Kunii; Mizuki Hino; Junya Matsumoto; Hirooki Yabe; Takeharu Nagai; Katsumasa Fujita; Toshio Matsuda; Kazuhiro Takuma; Akemichi Baba; Hitoshi Hashimoto
        NEURON, Jun. 2017, Peer-reviewed
      • Elucidation of the Role of Dorsal Raphe Serotonergic Neurons in Mood Regulation Using Pharmacological and Viral Vector-based Approaches
        Kazuki Nagayasu
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Mar. 2017, Peer-reviewed
      • Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells frommonozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine
        Takanobu Nakazawa; Masataka Kikuchi; Mitsuru Ishikawa; Hidenaga Yamamori; Kazuki Nagayasu; Takuya Matsumoto; Michiko Fujimoto; Yuka Yasuda; Mikiya Fujiwara; Shota Okada; Kensuke Matsumura; Atsushi Kasai; Atsuko Hayata-Takano; Norihito Shintani; Shusuke Numata; Kazuhiro Takuma; Wado Akamatsu; Hideyuki Okano; Akihiro Nakaya; Hitoshi Hashimoto; Ryota Hashimoto
        SCHIZOPHRENIA RESEARCH, Mar. 2017, Peer-reviewed
      • セロトニン神経機能の光/化学遺伝学的解析の現状
        永安一樹
        精神科, Jan. 2017, Invited, Lead author, Last author, Corresponding author
      • Pharmacological approach for elucidating the role of dorsal raphe serotonin neurons in mood/emotion regulation.
        Nagayasu K; Kaneko S
        Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2017, Peer-reviewed
      • A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons
        Nozomi Asaoka; Hiroyuki Kawai; Naoya Nishitani; Haruko Kinoshita; Norihiro Shibui; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko
        JOURNAL OF TOXICOLOGICAL SCIENCES, Dec. 2016, Peer-reviewed
      • Prostaglandin D-2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction
        Yusuke Onaka; Norihito Shintani; Takanobu Nakazawa; Takuya Kanoh; Yukio Ago; Toshio Matsuda; Ryota Hashimoto; Kazutaka Ohi; Hiroyuki Hirai; Kin-ya Nagata; Masataka Nakamura; Atsushi Kasai; Atsuko Hayata-Takano; Kazuki Nagayasu; Kazuhiro Takuma; Asao Ogawa; Akemichi Baba; Hitoshi Hashimoto
        BEHAVIOURAL BRAIN RESEARCH, Nov. 2016, Peer-reviewed
      • Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder
        Ryota Hashimoto; Takanobu Nakazawa; Yoshinori Tsurusaki; Yuka Yasuda; Kazuki Nagayasu; Kensuke Matsumura; Hitoshi Kawashima; Hidenaga Yamamori; Michiko Fujimoto; Kazutaka Ohi; Satomi Umeda-Yano; Masaki Fukunaga; Haruo Fujino; Atsushi Kasai; Atsuko Hayata-Takano; Norihito Shintani; Masatoshi Takeda; Naomichi Matsumoto; Hitoshi Hashimoto
        JOURNAL OF HUMAN GENETICS, Mar. 2016, Peer-reviewed
      • De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.
        Matsumura K; Nakazawa T; Nagayasu K; Gotoda-Nishimura N; Kasai A; Hayata-Takano A; Shintani N; Yamamori H; Yasuda Y; Hashimoto R; Hashimoto H
        Journal of molecular psychiatry, 2016, Peer-reviewed
      • Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT6 receptors in the dorsal raphe nucleus
        Nozomi Asaoka; Kazuki Nagayasu; Naoya Nishitani; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        NEUROPHARMACOLOGY, Aug. 2015, Peer-reviewed
      • Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice
        Kazuya Ikeda; Shuhei Tomimoto; Soken Tsuchiya; Ken-Ichi Hamagami; Norihito Shintani; Yukihiko Sugimoto; Atsushi Ichikawa; Atsushi Kasai; Takanobu Nakazawa; Kazuki Nagayasu; Atsuko Hayata-Takano; Akemichi Baba; Hitoshi Hashimoto
        Biochemistry and Biophysics Reports, 01 Jul. 2015, Peer-reviewed
      • ATOMOXETINE REVERSES LOCOMOTOR HYPERACTIVITY, IMPAIRED NOVEL OBJECT RECOGNITION, AND PREPULSE INHIBITION IMPAIRMENT IN MICE LACKING PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE
        Y. Shibasaki; A. Hayata-Takano; K. Hazama; T. Nakazawa; N. Shintani; A. Kasai; K. Nagayasu; R. Hashimoto; M. Tanida; T. Katayama; S. Matsuzaki; K. Yamada; M. Taniike; Y. Onaka; Y. Ago; J. A. Waschek; K. Koeves; D. Regloedi; A. Tamas; T. Matsuda; A. Baba; H. Hashimoto
        NEUROSCIENCE, Jun. 2015, Peer-reviewed
      • p13 overexpression in pancreatic beta-cells ameliorates type 2 diabetes in high-fat-fed mice
        Shintaro Higashi; Kazuhiko Katagi; Norihito Shintani; Kazuya Ikeda; Yukihiko Sugimoto; Soken Tsuchiya; Naoki Inoue; Shota Tanaka; Mai Koumoto; Atsushi Kasai; Takanobu Nakazawa; Atsuko Hayata-Takano; Ken-Ichi Hamagami; Shuhei Tomimoto; Takuya Yoshida; Tadayasu Ohkubo; Kazuki Nagayasu; Yukio Ago; Yusuke Onaka; Ryota Hashimoto; Atsushi Ichikawa; Akemichi Baba; Hitoshi Hashimoto
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2015, Peer-reviewed
      • CRTH2, a prostaglandin D-2 receptor, mediates depression-related behavior in mice
        Yusuke Onaka; Norihito Shintani; Takanobu Nakazawa; Ryota Haba; Yukio Ago; Hyper Wang; Takuya Kanoh; Atsuko Hayata-Takano; Hiroyuki Hirai; Kin-ya Nagata; Masataka Nakamura; Ryota Hashimoto; Toshio Matsuda; James A. Waschek; Atsushi Kasai; Kazuki Nagayasu; Akemichi Baba; Hitoshi Hashimoto
        BEHAVIOURAL BRAIN RESEARCH, May 2015, Peer-reviewed
      • Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus
        Yuki Imoto; Toshihiko Kira; Mamiko Sukeno; Naoya Nishitani; Kazuki Nagayasu; Takayuki Nakagawa; Shuji Kaneko; Katsunori Kobayashi; Eri Segi-Nishida
        MOLECULAR BRAIN, May 2015, Peer-reviewed
      • Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures
        Nozomi Asaoka; Kazuki Nagayasu; Naoya Nishitani; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        NEUROSCIENCE LETTERS, Apr. 2015, Peer-reviewed
      • Utility of organotypic raphe slice cultures to investigate the effects of psychotropic drugs on the function of serotoninergic neurons
        Takayuki Nakagawa; Kazuki Nagayasu; Shuji Kaneko
        JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Apr. 2015, Peer-reviewed
      • Simultaneous neuron- and astrocyte-specific fluorescent marking
        Wiebke Schulze; Atsuko Hayata-Takano; Toshihiko Kamo; Takanobu Nakazawa; Kazuki Nagayasu; Atsushi Kasai; Kaoru Seiriki; Norihito Shintani; Yukio Ago; Camille Farfan; Ryota Hashimoto; Akemichi Baba; Hitoshi Hashimoto
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2015, Peer-reviewed
      • PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF
        Katsuya Ogata; Norihito Shintani; Atsuko Hayata-Takano; Toshihiko Kamo; Shintaro Higashi; Kaoru Seiriki; Hisae Momosaki; David Vaudry; Hubert Vaudry; Ludovic Galas; Atsushi Kasai; Kazuki Nagayasu; Takanobu Nakazawa; Ryota Hashimoto; Yukio Ago; Toshio Matsuda; Akemichi Baba; Hitoshi Hashimoto
        PLOS ONE, Mar. 2015, Peer-reviewed
      • A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells
        Sergey Malchenko; Simone Treiger Sredni; Hitoshi Hashimoto; Atsushi Kasai; Kazuki Nagayasu; Jianping Xie; Naira V. Margaryan; Kaoru Seiriki; Rishi R. Lulla; Richard E. B. Seftor; Lauren M. Pachman; Herbert Y. Meltzer; Mary J. C. Hendrix; Marcelo B. Soares
        PLOS ONE, Mar. 2015, Peer-reviewed
      • Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro
        Atsushi Yamasaki; Atsushi Kasai; Akihiro Toi; Maki Kurita; Saki Kimoto; Atsuko Hayata-Takano; Takanobu Nakazawa; Kazuki Nagayasu; Norihito Shintani; Ryota Hashimoto; Akira Ito; Herbert Y. Meltzer; Yukio Ago; James A. Waschek; Yusuke Onaka; Toshio Matsuda; Akemichi Baba; Hitoshi Hashimoto
        JOURNAL OF NEUROCHEMISTRY, Feb. 2015, Peer-reviewed
      • 縫線核脳切片培養系の特徴と向精神薬によるセロトニン神経機能変化の作用解析
        中川貴之; 永安一樹; 金子周司
        日本神経精神薬理学雑誌, 2015, Peer-reviewed, Invited
      • ケタミンは縫線核AMPA受容体及びニコチン性アセチルコリン受容体を介して前頭前皮質5-HT遊離を引き起こす
        西谷 直也; 永安 一樹; 浅岡 希美; 山城 茉弓; 白川 久志; 中川 貴之; 金子 周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2014
      • Behavioral characterization of mice overexpressing human dysbindin-1
        Norihito Shintani; Yusuke Onaka; Ryota Hashimoto; Hironori Takamura; Tsuyoshi Nagata; Satomi Umeda-Yano; Akihiro Mouri; Takayoshi Mamiya; Ryota Haba; Shinsuke Matsuzaki; Taiichi Katayama; Hidenaga Yamamori; Takanobu Nakazawa; Kazuki Nagayasu; Yukio Ago; Yuki Yagasaki; Toshitaka Nabeshima; Masatoshi Takeda; Hitoshi Hashimoto
        MOLECULAR BRAIN, Oct. 2014, Peer-reviewed
      • Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex
        Naoya Nishitani; Kazuki Nagayasu; Nozomi Asaoka; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Aug. 2014, Peer-reviewed
      • Control of Intermale Aggression by Medial Prefrontal Cortex Activation in the Mouse
        Aki Takahashi; Kazuki Nagayasu; Naoya Nishitani; Shuji Kaneko; Tsuyoshi Koide
        PLOS ONE, Apr. 2014, Peer-reviewed
      • Central CRTH2, a Second Prostaglandin D-2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model
        Ryota Haba; Norihito Shintani; Yusuke Onaka; Takuya Kanoh; Hyper Wang; Risa Takenaga; Atsuko Hayata; Hiroyuki Hirai; Kin-ya Nagata; Masataka Nakamura; Atsushi Kasai; Ryota Hashimoto; Kazuki Nagayasu; Takanobu Nakazawa; Hitoshi Hashimoto; Akemichi Baba
        JOURNAL OF NEUROSCIENCE, Feb. 2014, Peer-reviewed
      • Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice
        Keisuke Hazama; Atsuko Hayata-Takano; Kazuki Uetsuki; Atsushi Kasai; Naoki Encho; Norihito Shintani; Kazuki Nagayasu; Ryota Hashimoto; Dora Reglodi; Tsuyoshi Miyakawa; Takanobu Nakazawa; Akemichi Baba; Hitoshi Hashimoto
        PLOS ONE, Feb. 2014, Peer-reviewed
      • Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release
        Kazuki Nagayasu; Maiko Kitaichi; Naoya Nishitani; Nozomi Asaoka; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Nov. 2013, Peer-reviewed
      • 光遺伝学的手法を用いた背側縫線核セロトニン神経の特異的刺激による行動学的変化
        西谷 直也; 永安 一樹; 浅岡 希美; 山城 茉弓; 白川 久志; 中川 貴之; 金子 周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2013
      • セロトニン神経における光遺伝学的解析を可能とするレンチウイルスベクターの開発
        永安 一樹; 浅岡 希美; 西谷 直也; 山城 茉弓; 白川 久志; 中川 貴之; 金子 周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2013
      • Transient Receptor Potential Canonical 3 Inhibitor Pyr3 Improves Outcomes and Attenuates Astrogliosis After Intracerebral Hemorrhage in Mice
        Masaya Munakata; Hisashi Shirakawa; Kazuki Nagayasu; Jun Miyanohara; Takahito Miyake; Takayuki Nakagawa; Hiroshi Katsuki; Shuji Kaneko
        STROKE, Jul. 2013, Peer-reviewed
      • YOKUKANSAN INHIBITS MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE IN MICE: THE ROLE OF alpha(2A)-ADRENOCEPTOR
        T. Nakagawa; K. Nagayasu; N. Nishitani; H. Shirakawa; K. Sekiguchi; Y. Ikarashi; Y. Kase; S. Kaneko
        NEUROSCIENCE, Dec. 2012, Peer-reviewed
      • 抗精神薬の縫線核培養切片への処置はセロトニンの遊離を引き起こす
        永安 一樹; 北市 麻衣子; 浅岡 希美; 西谷 直也; 白川 久志; 中川 貴之; 金子 周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2012
      • 抗うつ薬持続処置が縫線核培養切片での5-HT遊離に与える影響
        北市 麻衣子; 永安 一樹; 白川 久志; 中川 貴之; 金子 周司
        日本薬理学雑誌, Oct. 2011
      • 縫線核培養切片を用いた抗うつ薬持続処置が5-HT遊離に与える影響の比較解析
        北市 麻衣子; 永安 一樹; 白川 久志; 中川 貴之; 金子 周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2011
      • Repeated Exposure to Methamphetamine, Cocaine or Morphine Induces Augmentation of Dopamine Release in Rat Mesocorticolimbic Slice Co-Cultures
        Takayuki Nakagawa; Yuichi Suzuki; Kazuki Nagayasu; Maiko Kitaichi; Hisashi Shirakawa; Shuji Kaneko
        PLOS ONE, Sep. 2011, Peer-reviewed
      • 抗うつ薬持続処置によるセロトニン遊離増強におけるAMPA受容体の関与
        更田 宏史; 永安 一樹; 北市 麻衣子; 白川 久志; 中川 貴之; 金子 周司
        日本薬理学雑誌, Mar. 2011
      • Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective 5-HT reuptake inhibitors on 5-HT release
        Kazuki Nagayasu; Yumi Yatani; Maiko Kitaichi; Yutaka Kitagawa; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2010, Peer-reviewed
      • 抗うつ薬の縫線核培養切片への持続処置はAMPA受容体依存的な開口放出によるセロトニンの遊離を増強する
        永安 一樹; 北市 麻衣子; 白川 久志; 中川 貴之; 金子 周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2010
      • Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
        Kazuki Nagayasu; Maiko Kitaichi; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Jun. 2010, Peer-reviewed
      • 縫線核セロトニン神経含有中脳冠状切片におけるSSRI持続処置によるセロトニン遊離増強現象のメカニズム
        中川 貴之; 永安 一樹; 八谷 有美; 北市 麻衣子; 白川 久志; 金子 周司
        日本薬学会年会要旨集, Mar. 2010
      • Augmentation of serotonin release by sustained exposure to MDMA and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons
        Megumi Higuchi; Yuichi Suzuki; Yumi Yatani; Yutaka Kitagawa; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        JOURNAL OF NEUROCHEMISTRY, Sep. 2008, Peer-reviewed

      Misc.

      • セロトニン神経伝達の亢進は悲観的な意思決定を改善した
        安藤千紘; 西谷直也; 西谷直也; 高山海都; 澁井紀宏; 永安一樹; 白川久志; 金子周司
        日本薬理学雑誌, 2020
      • TRPV4開口はミクログリアの活性化状態を抗炎症型へ分極させる
        桑田沙織; 富澤恵里; 三宅崇仁; 永安一樹; 白川久志; 金子周司
        日本薬理学雑誌, 2020
      • Elucidation of the role of dorsal raphe nucleus serotonergic neurons in controlling preference / aversion
        永井佑茉; 高山海都; 安藤千紘; 永安一樹; 白川久志; 金子周司
        日本薬学会年会要旨集(CD-ROM), 2020
      • TRPV4 activation enhances LPS-induced IL10 production and shifts polarization toward anti-inflammatory phenotype
        白川久志; 富澤恵里; 桑田沙織; 永安一樹; 金子周司
        日本薬学会年会要旨集(CD-ROM), 2020
      • Therapeutic potential of 5-HT2C receptor antagonism for obsessive-compulsive disorder.
        幡鎌輝; 浅岡希美; 浅岡希美; 永安一樹; 白川久志; 金子周司
        日本薬学会年会要旨集(CD-ROM), 2020
      • 中枢神経疾患および炎症反応におけるミクログリアの中心的な役割
        白川久志; 永安一樹; 金子周司
        日本薬学会年会要旨集(CD-ROM), 2019
      • コカイン関連記憶の獲得および想起における内側前頭前野グルタミン酸作動性ニューロンの役割
        Zhang Tong; 上居 寛典; 柳田 淳子; 和田 進太郎; 堂本 将輝; 出山 諭司; 宝田 剛志; 檜井 栄一; 崎村 建司; 山中 章弘; 前島 隆司; 三枝 理博; 櫻井 武; 西谷 直也; 永安 一樹; 金子 周司; 南 雅文; 金田 勝幸
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2018
      • コカイン関連記憶の獲得および想起における内側前頭前野グルタミン酸作動性ニューロンの役割
        Zhang Tong; 上居 寛典; 柳田 淳子; 和田 進太郎; 堂本 将輝; 出山 諭司; 宝田 剛志; 檜井 栄一; 崎村 建司; 山中 章弘; 前島 隆司; 三枝 理博; 櫻井 武; 西谷 直也; 永安 一樹; 金子 周司; 南 雅文; 金田 勝幸
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2018
      • ノイロトロピンは持続性Kv電流増加を介してDRGニューロンの活動を抑制する
        河合洋幸; 浅岡希美; 三宅崇仁; 永安一樹; 中川貴之; 白川久志; 金子周司
        Pain Research, 2018
      • TRPM2活性化を介したマクロファージからのCXCL2産生が多発性硬化症の病態を増悪させる
        白川久志; 平瀬僚; 筒井真人; 宮村咲映; 永安一樹; 金子周司
        日本薬理学雑誌, 2018
      • オリゴデンドロサイト前駆細胞におけるTRPV4開口は増殖を促進する
        大橋佳奈; 出屋敷綾音; 三宅崇仁; 永安一樹; 柴崎貢志; 白川久志; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2018
      • 1型糖尿病モデルで生じる感覚異常に対する血流障害およびTRPA1の関与
        緋山遥; 宗可奈子; 矢野佑一; 永安一樹; 白川久志; 中川貴之; 金子周司
        生体機能と創薬シンポジウム要旨集, 2017
      • マウス慢性脳低灌流モデルにおけるTRPM2の病態生理学的役割
        宮之原遵; 抱将史; 永安一樹; 森泰生; 白川久志; 金子周司
        生体機能と創薬シンポジウム要旨集, 2017
      • TRPV4刺激はマウス脳内出血モデルにおける神経機能障害を改善する
        白川久志; 浅尾靖仁; 抱将史; 永安一樹; 中川貴之; 金子周司
        日本薬学会年会要旨集(CD-ROM), 2017
      • 炎症性中枢疾患と単球系細胞TRPチャネル
        白川久志; 永安一樹; 金子周司
        生体機能と創薬シンポジウム要旨集, 2017
      • 糖尿病性神経障害モデルでの感覚異常と血流障害およびTRPA1の関与
        緋山遥; 宗可奈子; 矢野佑一; 永安一樹; 白川久志; 中川貴之; 金子周司
        Pain Research, 2017
      • TRPM2を介したケモカインCXCL2産生が多発性硬化症の増悪に関与する
        平瀬僚; 筒井真人; 永安一樹; 白川久志; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2017
      • グリア細胞・免疫細胞TRPチャネルの病態生理学的役割と中枢性脱髄疾患克服への応用
        白川久志; 永安一樹; 中川貴之; 金子周司
        生体膜と薬物の相互作用シンポジウム講演要旨集, 2017
      • ミクログリアにおいてTRPV4の開口はLPS誘発IL10産生を促進する
        富澤恵里; 三宅崇仁; 永安一樹; 白川久志; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2017
      • 認知機能制御におけるプロスタグランジンDP2受容体の役割(The role of prostanoid DP2 receptor in the regulation of cognitive function)
        新谷 紀人; 尾中 勇祐; 叶 拓也; 中澤 敬信; 吾郷 由希夫; 松田 敏夫; 橋本 亮太; 大井 一高; 平井 博之; 永田 欽也; 中村 正孝; 笠井 淳司; 早田 敦子; 野; 永安 一樹; 馬場 明道; 橋本 均
        日本神経精神薬理学会年会プログラム・抄録集, Jul. 2016
      • Studies on the molecular mechanism of clozapine action with iPSC technology
        Fujiwara Mikiya; Kikuchi Masataka; Nagayasu Kazuki; Nakazawa Takanobu; Yamamori Hidenaga; Kasai Atsushi; Hayata-Takano Atsuko; Shintani Norihito; Fujimoto Michiko; Yasuda Yuka; Ishikawa Mitsuru; Akamatsu Wado; Okano Hideyuki; Nakaya Akihiro; Hashimoto Hitoshi; Hashimoto Ryota
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, Peer-reviewed
      • 過酸化水素誘発膀胱炎モデルにおけるTRPA1の病態生理学的役割
        尾山翔平; 土岸広治; 小寺みずき; 永安一樹; 白川久志; 中川貴之; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2016
      • 危険ドラッグ5F-ADBのドパミン・セロトニン神経活動に対する作用
        浅岡希美; 河合洋幸; 西谷直也; 木ノ下晴子; 澁井紀宏; 永安一樹; 白川久志; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2016
      • オリゴデンドロサイト前駆細胞の増殖および分化におけるTRPV4の生理的役割
        出屋敷綾音; 三宅崇仁; 永安一樹; 白川久志; 中川貴之; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2016
      • PACAPシグナルによる精神神経機能調節におけるセロトニン2A受容体シグナルの関与
        早田敦子; 狭間啓佑; 森口啓太; 吾郷由希夫; 円丁直樹; 中澤敬信; 永安一樹; 笠井淳司; 尾中勇祐; 新谷紀人; 馬場明道; 橋本均
        日本神経精神薬理学雑誌, 2015
      • 自閉症の疾患特異的候補遺伝子の機能的スクリーニング系の確立
        松村 憲佑; 永安 一樹; 中澤 敬信; 安田 由華; 山森 英長; 梅田 知美; 大井 一高; 橋本 亮太; 武田 雅俊; 橋本 均
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2014
      • iPS細胞を用いた精神疾患の分子病態研究の現状と展望 iPS細胞関連技術を用いた統合失調症研究
        中澤 敬信; 橋本 亮太; 永安 一樹; 安田 由華; 山森 英長; 梅田 知美; 藤本 美智子; 大井 一高; 石川 充; 赤松 和土; 岡野 栄之; 武田 雅俊; 橋本 均
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Nov. 2014
      • ヒストン脱アセチル化酵素阻害薬の持続処置が縫線核セロトニン神経に与える影響
        浅岡希美; 永安一樹; 永安一樹; 永安一樹; 西谷直也; 山城茉弓; 白川久志; 中川貴之; 中川貴之; 金子周司
        日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 2014
      • セロトニン神経特異的レンチウイルスベクターの開発と光遺伝学的解析への応用
        永安一樹; 永安一樹; 西谷直也; 浅岡希美; 山城茉弓; 白川久志; 中川貴之; 金子周司
        生体機能と創薬シンポジウム要旨集, 2014
      • Optogenetic activation of the mPFC and escalated aggression
        Aki Takahashi; Kazuki Nagayasu; Shuzi Kaneko; Tsuyoshi Koide
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
      • The balance between BMP and TGF-beta signaling at an early stage steers serotonergic differentiation from ES cells
        Atsushi Yamasaki; Atsushi Kasai; Akihiro Toi; Maki Kurita; Atsuko Hayata-Takano; Kazuki Nagayasu; Norihito Shintani; Akemichi Baba; Hitoshi Hashimoto
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
      • Optogenetic stimulation of dorsal raphe serotonergic neurons produces antidepressant-like effect in mice
        Naoya Nishitani; Kazuki Nagayasu; Nozomi Asaoka; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
      • Sustained SSRI exposure induces augmentation of 5-HT release dependent on AMPA receptors in cultured serotonergic neurons
        Kazuki Nagayasu; Hiroshi Fuketa; Maiko Kitaichi; Naoya Nishitani; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012
      • 抗うつ薬持続処置が縫線核培養切片での5-HT遊離に与える影響
        北市麻衣子; 永安一樹; 白川久志; 中川貴之; 金子周司
        日本薬理学会近畿部会プログラム・要旨集, 2011
      • 縫線核セロトニン神経含有中脳冠状切片におけるSSRI持続処置によるセロトニン遊離増強現象のメカニズム
        中川貴之; 永安一樹; 八谷有美; 北市麻衣子; 白川久志; 金子周司
        日本薬学会年会要旨集, 2010
      • MECHANISMS OF SEROTONERGIC SENSITIZATION INDUCED BY SUSTAINED MDMA EXPOSURE IN RAT ORGANOTYPIC MESENCEPHALIC SLICE CULTURES
        Takayuki Nakagawa; Megumi Higuchi; Kazuki Nagayasu; Yuichi Suzuki; Yumi Yatani; Hisashi Shirakawa; Shuji Kaneko
        JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009
      • Molecular biological analyses of the augmentation of 5-HT release by sustained MDMA in organotypic raphe slice culture
        Kazuki Nagayasu; Megumi Higuchi; Yumi Yatani; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        NEUROSCIENCE RESEARCH, 2009
      • Augmentation of serotonin release by chronic exposure to selective serotonin reuptake inhibitors in rat organotypic mesencephalic slice cultures containing raphe-serotonergic neurons
        Yumi Yatani; Yutaka Kitagawa; Megumi Higuchi; Kazuki Nagayasu; Hiroshi Fuketa; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008

      Books and Other Publications

      External funds: Kakenhi

      • 臓器感覚入力系におけるモノアミン神経細胞の情動表現解析
        Grant-in-Aid for Scientific Research (C)
        Basic Section 51020:Cognitive and brain science-related
        Kansai Medical University
        安田 正治
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        背側縫線核;青斑核;迷走神経;サル;情動
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07266/
      • うつ病態発症・治療の決定因子の同定
        Grant-in-Aid for Scientific Research (C)
        Basic Section 47040:Pharmacology-related
        Kyoto University
        永安 一樹
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        セロトニン;うつ病;光遺伝学;TRAP
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07064/
      • 低分子から中分子に至るあらゆる化学構造のヒト作用予測モデルの開発
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Kyoto University
        永安 一樹
        From 01 Apr. 2020, To 31 Mar. 2022, Granted
        深層学習;ケミカルバイオロジー;臨床情報;セロトニン;薬理学;ビッグデータ
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H04774/
      • Drug target finding based on the analysis of real world data
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 47:Pharmaceutical sciences and related fields
        Kyoto University
        金子 周司
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        リアルワールドデータ;有害事象;ドラッグリポジショニング;レセプト;AI創薬
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00491/
      • 霊長類セロトニン系の光操作による心と体の相互関係のメカニズムの解明
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 51:Brain sciences and related fields
        Kansai Medical University
        中村 加枝
        From 28 Jun. 2019, To 31 Mar. 2022, Granted
        自律神経;扁桃体;サル;大脳基底核;光遺伝学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22582/
      • 負の情動下の意思決定行動変容の神経基盤：拡張扁桃体-大脳基底核回路の探求
        Grant-in-Aid for Scientific Research (B)
        Basic Section 51020:Cognitive and brain science-related
        Kansai Medical University
        中村 加枝
        From 01 Apr. 2019, To 31 Mar. 2024, Granted
        大脳基底核;意思決定;ストレス;自律神経反応;セロトニン;拡張扁桃体;黒質網様体;背側縫線核;負の情動;光遺伝学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03540/
      • International collaboration for the study of drug action based on real-world clinical data
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
        Medium-sized Section 47:Pharmaceutical sciences and related fields
        Kyoto University
        金子 周司
        From 09 Oct. 2018, To 31 Mar. 2023, Granted
        臨床ビッグデータ;深層学習;電子カルテ;薬物依存;有害事象;ビッグデータ;医療情報;オントロジ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0216/
      • Identification of antidepressive serotonin projection as a possible target of cell transplantation therapy
        Grant-in-Aid for Early-Career Scientists
        Basic Section 47040:Pharmacology-related
        Kyoto University
        Kazuki Nagayasu
        From 01 Apr. 2018, To 31 Mar. 2020, Project Closed
        セロトニン;抗うつ薬;光遺伝学;うつ病;ウイルスベクター;幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14919/
      • The role of serotonin projection under negative emotions.
        Grant-in-Aid for Scientific Research (C)
        Basic Section 51020:Cognitive and brain science-related
        Kansai Medical University
        Masaharu YASUDA
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        サル;情動;ストレス;背側縫線核;セロトニン;光遺伝学;黒質網様部;認知;報酬;自律神経;光遺伝学的
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07356/
      • Genetic tools for circuit-based drug discovery
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Kazuki Nagayasu
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        ウイルスベクター;セロトニン;光遺伝学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15125/
      • Identification and pharmacological control of serotonergic projection involved in decision making
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Shuji Kaneko
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        セロトニン;ウイルスベクター;うつ病;強迫性障害;精神疾患;ドパミン;意思決定;光遺伝学;神経薬理学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05091/
      • Studies on mental disorder using patient-specific iPS cells
        Grant-in-Aid for Young Scientists (B)
        Osaka University
        Kazuki Nagayasu
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        幹細胞;ウイルスベクター;精神疾患;iPS細胞;神経幹細胞;神経細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860055/
      • A research on the effects of miRNAs on serotonergic neuronal functions
        Grant-in-Aid for Challenging Exploratory Research
        Osaka University
        Hitoshi Hashimoto
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        セロトニン;miRNA;幹細胞;国際情報交換（アメリカ合衆国）
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670122/
      list
        Last Updated :2022/08/09

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology
          A905, Fall, Faculty of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology
          C905, Fall, Faculty of Pharmaceutical Sciences, 3
        • From Apr. 2017, To Mar. 2018
          Pre-Training for Clinical Clerkship
          Year-long, 薬学部
        • From Apr. 2018, To Mar. 2019
          Fundamental Chemical Experiments
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology
          Fall, 薬学部
        • From Apr. 2019, To Mar. 2020
          Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology
          Fall, 薬学部
        • From Apr. 2020, To Mar. 2021
          Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology
          Fall, 薬学部
        • From Apr. 2021, To Mar. 2022
          Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology
          Fall, 薬学部

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