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阪中 幹祥

サカナカ ミキヤス

生命科学研究科 ヒト常在性ビフィズス菌(HRB)研究講座(産学共同) 特定准教授

阪中 幹祥
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    Last Updated :2022/05/14

    基本情報

    所属学協会

    • 日本農芸化学会
    • 腸内細菌学会
    • 日本乳酸菌学会

    学位

    • 修士(農学)(北海道大学)
    • 博士(農学)(北海道大学)

    経歴

    • 自 2020年10月, 至 現在
      京都大学, 大学院生命科学研究科, 特定准教授
    • 自 2020年09月, 至 2020年09月
      京都大学, 大学院生命科学研究科, 特定研究員
    • 自 2018年09月, 至 2020年08月
      Technical University of Denmark, National Food Institute, Visiting Researcher (日本学術振興会 海外特別研究員)
    • 自 2017年04月, 至 2018年08月
      石川県立大学, 生物資源環境学部, 寄附講座助教
    • 自 2015年04月, 至 2017年03月
      石川県立大学, 生物資源環境学部, 特別研究員

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      研究

      研究キーワード

      • ビフィズス菌
      • 腸内細菌
      • 遺伝子操作
      • 糖質加水分解酵素
      • トランスポーター
      • オリゴ糖

      研究分野

      • ライフサイエンス, 分子生物学
      • ライフサイエンス, 機能生物化学
      • ライフサイエンス, 応用生物化学
      • ライフサイエンス, 応用微生物学

      論文

      • Diversification of a fucosyllactose transporter within the genus Bifidobacterium.
        Miriam N Ojima; Yuya Asao; Aruto Nakajima; Toshihiko Katoh; Motomitsu Kitaoka; Aina Gotoh; Junko Hirose; Tadasu Urashima; Satoru Fukiya; Atsushi Yokota; Maher Abou Hachem; Mikiyasu Sakanaka; Takane Katayama
        Applied and Environmental Microbiology, 2021年11月, 査読有り
      • Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut.
        Martin F Laursen; Mikiyasu Sakanaka; Nicole von Burg; Urs Mörbe; Daniel Andersen; Janne Marie Moll; Ceyda T Pekmez; Aymeric Rivollier; Kim F Michaelsen; Christian Mølgaard; Mads Vendelbo Lind; Lars O Dragsted; Takane Katayama; Henrik L Frandsen; Anne Marie Vinggaard; Martin I Bahl; Susanne Brix; William Agace; Tine R Licht; Henrik M Roager
        Nature Microbiology, 2021年10月, 査読有り
      • Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile
        Rika Hirano; Mikiyasu Sakanaka; Kazuto Yoshimi; Naohisa Sugimoto; Syogo Eguchi; Yuko Yamauchi; Misaki Nara; Shingo Maeda; Yuta Ami; Aina Gotoh; Takane Katayama; Noriho Iida; Tamotsu Kato; Hiroshi Ohno; Satoru Fukiya; Atsushi Yokota; Mamoru Nishimoto; Motomitsu Kitaoka; Hiroyuki Nakai; Shin Kurihara
        Gut Microbes, 2021年09月, 査読有り
      • Evolution of milk oligosaccharides: Origin and selectivity of the ratio of milk oligosaccharides to lactose among mammals
        Tadasu Urashima; Takane Katayama; Mikiyasu Sakanaka; Kenji Fukuda; Michael Messer
        Biochimica et Biophysica Acta (BBA) - General Subjects, 2021年09月, 査読有り
      • Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics.
        Miriam N Ojima; Keisuke Yoshida; Mikiyasu Sakanaka; Lin Jiang; Toshitaka Odamaki; Takane Katayama
        Current Opinion in Biotechnology, 2021年08月, 査読有り
      • Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter
        Keisuke Yoshida; Rika Hirano; Yohei Sakai; Moonhak Choi; Mikiyasu Sakanaka; Shin Kurihara; Hisakazu Iino; Jin-zhong Xiao; Takane Katayama; Toshitaka Odamaki
        Communications Biology, 2021年05月, 査読有り
      • Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways
        Michael Jakob Pichler; Chihaya Yamada; Bashar Shuoker; Camila Alvarez-Silva; Aina Gotoh; Maria Louise Leth; Erwin Schoof; Toshihiko Katoh; Mikiyasu Sakanaka; Takane Katayama; Chunsheng Jin; Niclas G. Karlsson; Manimozhiyan Arumugam; Shinya Fushinobu; Maher Abou Hachem
        Nature Communications, 2020年07月, 査読有り
      • Development of a new chromogenic method for putrescine quantification using coupling reactions involving putrescine oxidase
        Yuta Sugiyama; Hirokazu Ohta; Rika Hirano; Hiromi Shimokawa; Mikiyasu Sakanaka; Takashi Koyanagi; Shin Kurihara
        Analytical Biochemistry, 2020年03月, 査読有り
      • Application of Recombinase-Based In Vivo Expression Technology to Bifidobacterium longum subsp. longum for Identification of Genes Induced in the Gastrointestinal Tract of Mice
        Hiroka Koguchi; Natsumi Ishigami; Mikiyasu Sakanaka; Kako Yoshida; Sayaka Hiratou; Mina Shimada; Satoru Fukiya; Kei Sonoyama; Atsushi Yokota
        Microorganisms, 2020年03月, 査読有り
      • Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules
        Toshihiko Katoh; Miriam N. Ojima; Mikiyasu Sakanaka; Hisashi Ashida; Aina Gotoh; Takane Katayama
        Microorganisms, 2020年03月, 査読有り
      • Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation
        Mikiyasu Sakanaka; Aina Gotoh; Keisuke Yoshida; Toshitaka Odamaki; Hiroka Koguchi; Jin-zhong Xiao; Motomitsu Kitaoka; Takane Katayama
        Nutrients, 2019年12月, 査読有り
      • Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis
        Mikiyasu Sakanaka; Morten Ejby Hansen; Aina Gotoh; Toshihiko Katoh; Keisuke Yoshida; Toshitaka Odamaki; Hiroyuki Yachi; Yuta Sugiyama; Shin Kurihara; Junko Hirose; Tadasu Urashima; Jin-zhong Xiao; Motomitsu Kitaoka; Satoru Fukiya; Atsushi Yokota; Leila Lo Leggio; Maher Abou Hachem; Takane Katayama
        Science Advances, 2019年08月, 査読有り
      • Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum
        Aina Gotoh; Toshihiko Katoh; Mikiyasu Sakanaka; Yiwei Ling; Chihaya Yamada; Sadaki Asakuma; Tadasu Urashima; Yusuke Tomabechi; Ayako Katayama-Ikegami; Shin Kurihara; Kenji Yamamoto; Gaku Harata; Fang He; Junko Hirose; Motomitsu Kitaoka; Shujiro Okuda; Takane Katayama
        Scientific Reports, 2018年12月, 査読有り
      • Analysis of polyamine biosynthetic- and transport ability of human indigenous Bifidobacterium
        Yuta Sugiyama; Misaki Nara; Mikiyasu Sakanaka; Aya Kitakata; Shujiro Okuda; Shin Kurihara
        Bioscience, Biotechnology, and Biochemistry, 2018年09月, 査読有り
      • A Transposon Mutagenesis System forBifidobacterium longumsubsp.longumBased on an IS3Family Insertion Sequence, ISBlo11
        Mikiyasu Sakanaka; Shingo Nakakawaji; Shin Nakajima; Satoru Fukiya; Arisa Abe; Wataru Saburi; Haruhide Mori; Atsushi Yokota
        Applied and Environmental Microbiology, 2018年06月, 査読有り
      • Functional analysis of arginine decarboxylase gene speA of Bacteroides dorei by markerless gene deletion
        Mikiyasu Sakanaka; Yuta Sugiyama; Misaki Nara; Aya Kitakata; Shin Kurihara
        FEMS Microbiology Letters, 2018年02月, 査読有り
      • Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes
        Yuta Sugiyama; Misaki Nara; Mikiyasu Sakanaka; Aina Gotoh; Aya Kitakata; Shujiro Okuda; Shin Kurihara
        The International Journal of Biochemistry & Cell Biology, 2017年12月, 査読有り
      • Use of Gifu Anaerobic Medium for culturing 32 dominant species of human gut microbes and its evaluation based on short-chain fatty acids fermentation profiles
        Aina Gotoh; Misaki Nara; Yuta Sugiyama; Mikiyasu Sakanaka; Hiroyuki Yachi; Aya Kitakata; Akira Nakagawa; Hiromichi Minami; Shujiro Okuda; Toshihiko Katoh; Takane Katayama; Shin Kurihara
        Bioscience, Biotechnology, and Biochemistry, 2017年10月, 査読有り
      • Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum
        Chihaya Yamada; Aina Gotoh; Mikiyasu Sakanaka; Mitchell Hattie; Keith A. Stubbs; Ayako Katayama-Ikegami; Junko Hirose; Shin Kurihara; Takatoshi Arakawa; Motomitsu Kitaoka; Shujiro Okuda; Takane Katayama; Shinya Fushinobu
        Cell Chemical Biology, 2017年04月, 査読有り
      • A Novel Putrescine Exporter SapBCDF ofEscherichia coli
        Yuta Sugiyama; Atsuo Nakamura; Mitsuharu Matsumoto; Ayaka Kanbe; Mikiyasu Sakanaka; Kyohei Higashi; Kazuei Igarashi; Takane Katayama; Hideyuki Suzuki; Shin Kurihara
        Journal of Biological Chemistry, 2016年12月, 査読有り
      • Carboxyspermidine decarboxylase of the prominent intestinal microbiota species Bacteroides thetaiotaomicron is required for spermidine biosynthesis and contributes to normal growth
        Mikiyasu Sakanaka; Yuta Sugiyama; Aya Kitakata; Takane Katayama; Shin Kurihara
        Amino Acids, 2016年10月, 査読有り
      • Isolation and transposition properties of ISBlo11, an active insertion sequence belonging to the IS3 family, from Bifidobacterium longum 105-A
        Mikiyasu Sakanaka; Satoru Fukiya; Ryoko Kobayashi; Arisa Abe; Yosuke Hirayama; Yasunobu Kano; Atsushi Yokota
        FEMS Microbiology Letters, 2015年04月01日, 査読有り
      • Complete Genome Sequence of Bifidobacterium longum 105-A, a Strain with High Transformation Efficiency
        Y. Kanesaki; H. Masutani; M. Sakanaka; Y. Shiwa; T. Fujisawa; Y. Nakamura; A. Yokota; S. Fukiya; T. Suzuki; H. Yoshikawa
        Genome Announcements, 2014年12月, 査読有り
      • Functional analysis of bifidobacterial promoters in Bifidobacterium longum and Escherichia coli using the α-galactosidase gene as a reporter
        Mikiyasu Sakanaka; Saki Tamai; Yosuke Hirayama; Ai Onodera; Hiroka Koguchi; Yasunobu Kano; Atsushi Yokota; Satoru Fukiya
        Journal of Bioscience and Bioengineering, 2014年11月, 査読有り
      • Development of a Double-Crossover Markerless Gene Deletion System in Bifidobacterium longum: Functional Analysis of the α-Galactosidase Gene for Raffinose Assimilation
        Yosuke Hirayama; Mikiyasu Sakanaka; Hidenori Fukuma; Hiroki Murayama; Yasunobu Kano; Satoru Fukiya; Atsushi Yokota
        Applied and Environmental Microbiology, 2012年07月, 査読有り
      • Technological Advances in Bifidobacterial Molecular Genetics: Application to Functional Genomics and Medical Treatments
        Satoru FUKIYA; Yosuke HIRAYAMA; Mikiyasu SAKANAKA; Yasunobu KANO; Atsushi YOKOTA
        Bioscience of Microbiota, Food and Health, 2012年04月, 査読有り

      講演・口頭発表等

      • 母乳オリゴ糖利用戦略から見えてきたビフィズス菌と宿主の共進化の軌跡
        阪中幹祥
        酪農科学シンポジウム2021, 2021年09月, 招待有り
      • 人乳成分の代謝から考えるビフィズス菌の適応進化戦略
        阪中幹祥
        ビフィズス菌研究会設立記念第一回シンポジウム, 2021年03月, 招待有り
      • Adaptive evolution strategy of bifidobacteria found from the characterization of human milk oligosaccharide transporters
        Mikiyasu Sakanaka
        The 43rd Annual Meeting of the Molecular Biology Society of Japan, 2020年12月, 招待有り
      • 乳児腸内で優勢なビフィズス菌の母乳オリゴ糖の資化戦略
        阪中幹祥
        第10回北陸合同バイオシンポジウム, 2017年11月, 招待有り

      外部資金:科学研究費補助金

      • ヒト腸内における初期定着細菌のオリゴ糖利用メカニズムの解明
        若手研究
        小区分38020:応用微生物学関連
        京都大学
        阪中 幹祥
        自 2021年04月01日, 至 2023年03月31日, 交付
        腸内細菌;ビフィズス菌;オリゴ糖;分子機構
      • ユニークな糖代謝から紐解くビフィズス菌と乳児の共生機構
        若手研究
        小区分38020:応用微生物学関連
        京都大学;石川県立大学
        阪中 幹祥
        自 2018年04月01日, 至 2021年03月31日, 完了
        ビフィズス菌;母乳オリゴ糖;トランスポーター;遺伝子操作;共生;遺伝子破壊

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