Basic Information

Professional Memberships

• 日本薬学会
• 日本生化学会

Academic Degree

• 11 Jun. 2014

  東京大学博士（薬学）
• 23 Mar. 2006

  東京大学修士（薬学）

Academic Resume (Graduate Schools)

• The University of Tokyo, Graduate School of Pharmaceutical Sciences

Academic Resume (Undergraduate School/Majors)

• The University of Tokyo, Department of Pharmaceutical Sciences, Graduation

Research History

• From Apr. 2020, To Mar. 2022

  Tohoku University, Graduate School of Pharmaceutical Sciences, Associate Professor
• From Sep. 2016, To Mar. 2020

  Tohoku University, Graduate School of Pharmaceutical Sciences, Associate Professor
• From Jul. 2014, To Aug. 2016

  Tohoku University, Graduate School of Pharmaceutical Sciences, Assistant Professor
• From Aug. 2008, To Jun. 2014

  Tohoku University, Graduate School of Pharmaceutical Sciences, Research Associate
• From Apr. 2024, To Present

  Kyoto University, Graduate School of Pharmaceutical Sciences, Professor
• From Apr. 2022, To Present

  Tohoku University, Graduate School of Pharmaceutical Sciences, Professor

Language of Instruction

• English
• Japanese

ID,URL

• ORCID ID

  0000-0003-0805-4049

• J-Global ID

  200901057936608094

• External link

  https://www.pharm.kyoto-u.ac.jp/pharmacology/index.html

Website(s) (URL(s))

• https://www.pharm.kyoto-u.ac.jp
• http://www.pharm.tohoku.ac.jp/~seika/2020/index.html

researchmap URL

• https://researchmap.jp/iaska

Research

Research Topics, Overview of the research

• Research Topics

  Signal transduction of G-protein-coupled receptors

Research Interests

• GPCR

Research Areas

• Life sciences, Pharmacology
• Life sciences, Pharmaceuticals - health and biochemistry
• Life sciences, Functional biochemistry

Papers

• Characterization of Gαs and Gαolf activation by catechol and non-catechol dopamine D1 receptor agonists.

  Anh Minh Nguyen; Ana Semeano; Vianna Quach; Asuka Inoue; David E Nichols; Hideaki Yano

  iScience, 16 May 2025

  
• An integrated mechanism of Gq regulation of PLCβ enzymes.

  Kanishka Senarath; Isaac J Fisher; Wonjo Jang; Sumin Lu; Asuka Inoue; Evi Kostenis; Angeline M Lyon; Nevin A Lambert

  Proceedings of the National Academy of Sciences of the United States of America, 22 Apr. 2025

  
• Arrestin-independent internalization of the GLP-1 receptor is facilitated by a GRK, clathrin, and caveolae-dependent mechanism.

  Ee Von Moo; Thor Christian Møller; Frederikke Astrid Sørensen; Asuka Inoue; Hans Bräuner-Osborne

  The FEBS journal, Apr. 2025

  
• Structure and dynamics determine G protein coupling specificity at a class A GPCR.

  Marina Casiraghi; Haoqing Wang; Patrick C Brennan; Chris Habrian; Harald Hübner; Maximilian F Schmidt; Luis Maul; Biswaranjan Pani; Sherif M F M Bahriz; Bing Xu; Nico Staffen; Tufa E Assafa; Bohan Chen; Elizabeth White; Roger K Sunahara; Asuka Inoue; Yang K Xiang; Robert J Lefkowitz; Ehud Y Isacoff; Nathaniel Nucci; Peter Gmeiner; Michael T Lerch; Brian K Kobilka

  Science advances, 21 Mar. 2025

  
• Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration.

  Hyunggu Hahn; Carole Daly; John Little 4th; Nicole A Perry-Hauser; Emmanuel Flores-Espinoza; Asuka Inoue; Bianca Plouffe; Alex R B Thomsen

  eLife, 24 Feb. 2025

  
• GRK5 regulates endocytosis of FPR2 independent of β-arrestins.

  Christine E Jack; Emily M Cope; Laura Lemel; Meritxell Canals; Julia Drube; Carsten Hoffmann; Asuka Inoue; James N Hislop; Dawn Thompson

  The Journal of biological chemistry, Feb. 2025

  
• Role of the G protein-coupled receptor kinase 2/3 N terminus in discriminating the endocytic effects of opioid agonist drugs.

  Joy Li; Asuka Inoue; Aashish Manglik; Mark von Zastrow

  Molecular pharmacology, Jan. 2025

  
• Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction.

  Saktimayee M Roy; Erica Acquarone; Elentina K Argyrousi; Hong Zhang; Agnieszka Staniszewski; Asuka Inoue; Joshua J Ziarek; Ottavio Arancio; D Martin Watterson

  Alzheimer's & dementia (New York, N. Y.), 2025

  
• Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part I: Impact of the Morphinan Skeleton on the G-Protein-Biased DOR Agonism.

  Keita Kajino; Tomoya Sugai; Ryoji Kise; Riko Suzuki; Akihisa Tokuda; Yuki Sekiya; Tomoya Kakumoto; Risako Katamoto; Noriki Kutsumura; Yasuyuki Nagumo; Asuka Inoue; Tsuyoshi Saitoh

  Chemical & pharmaceutical bulletin, 2025

  
• Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part II: Quinoline Ring Modifications for Enhanced G-Protein Signaling and Reduced β-Arrestin Recruitment.

  Keita Kajino; Tomoya Sugai; Tomoya Kakumoto; Ryoji Kise; Riko Suzuki; Akihisa Tokuda; Yuki Sekiya; Risako Katamoto; Noriki Kutsumura; Yasuyuki Nagumo; Takatsugu Hirokawa; Asuka Inoue; Tsuyoshi Saitoh

  Chemical & pharmaceutical bulletin, 2025

  
• Detection of Human GPCR Activity in Drosophila S2 Cells Using the Tango System.

  Emil Salim; Aki Hori; Kohei Matsubara; Toshiyuki Takano-Shimizu; Andre Rizky Pratomo; Marianne Marianne; Armia Syahputra; Dadang Irfan Husori; Asuka Inoue; Maryam Aisyah Abdullah; Nur Farisya Shamsudin; Kamal Rullah; Takayuki Kuraishi

  International journal of molecular sciences, 29 Dec. 2024

  
• Design of allosteric modulators that change GPCR G protein subtype selectivity.

  Madelyn N Moore; Kelsey L Person; Abigail Alwin; Campbell Krusemark; Noah Foster; Caroline Ray; Asuka Inoue; Michael R Jackson; Michael J Sheedlo; Lawrence S Barak; Ezequiel Marron Fernandez de Velasco; Steven H Olson; Lauren M Slosky

  Research square, 11 Dec. 2024

  
• G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis.

  Srinivas Pittala; Dhanush Haspula; Yinghong Cui; Won-Mo Yang; Young-Bum Kim; Roger J Davis; Allison Wing; Yaron Rotman; Owen P McGuinness; Asuka Inoue; Jürgen Wess

  Nature communications, 19 Nov. 2024

  
• Amylin receptor subunit interactions are modulated by agonists and determine signaling.

  Sandra E Gostynska; Jordan A Karim; Bailee E Ford; Peyton H Gordon; Katie M Babin; Asuka Inoue; Nevin A Lambert; Augen A Pioszak

  bioRxiv : the preprint server for biology, 09 Oct. 2024

  
• The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation

  Samantha M. McNeill; Jessica Lu; Carlo Marion C. Carino; Asuka Inoue; Peishen Zhao; Patrick M. Sexton; Denise Wootten

  Biochemical Pharmacology, Apr. 2024

  
• Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation.

  Akiharu Uwamizu; Yuji Shinjo; Jumpei Omi; Manae Tatstumi; Kuniyuki Kano; Kumiko Makide; Hajime Kitamura; Michiyo Okudaira; Keita Satoh; Fumiya Fukami; Tasuku Kawano; Tomomitsu Miyasaka; Tomoko Takahashi; Osamu Nakajima; Tomohiko Ohwada; Asuka Inoue; Junken Aoki

  iScience, Apr. 2025

  
• Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2.

  Mai Kugawa; Kouki Kawakami; Ryoji Kise; Carl-Mikael Suomivuori; Masaki Tsujimura; Kazuhiro Kobayashi; Asato Kojima; Wakana J Inoue; Masahiro Fukuda; Toshiki E Matsui; Ayami Fukunaga; Junki Koyanagi; Suhyang Kim; Hisako Ikeda; Keitaro Yamashita; Keisuke Saito; Hiroshi Ishikita; Ron O Dror; Asuka Inoue; Hideaki E Kato

  Nature communications, 26 Mar. 2025

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• Discovering Key Activation Hotspots in the M2 Muscarinic Receptor.

  Yuya Sugiura; Tatsuya Ikuta; Yuji Sumii; Hirokazu Tsujimoto; Kohei Suzuki; Ryoji Suno; Putri Nur Arina Binti Mohd Ariff; So Iwata; Norio Shibata; Asuka Inoue; Takuya Kobayashi; Hideki Kandori; Kota Katayama

  Journal of the American Chemical Society, 14 Mar. 2025

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• Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate.

  Akiyuki Nishimura; Kazuhiro Nishiyama; Tomoya Ito; Xinya Mi; Yuri Kato; Asuka Inoue; Junken Aoki; Motohiro Nishida

  Cells, 03 Feb. 2025

  
• Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

  Suno-Ikeda C; Nishikawa R; Suzuki R; Iwata S; Takai T; Ogura T; Hirose M; Inoue A; Asai E; Kise R; Sugita Y; Kato T; Nagase H; Saitoh T; Katayama K; Suno R

  Apr. 2024

  
• Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria.

  Yusuke Hirata; Yuto Yamada; Soma Taguchi; Ryota Kojima; Haruka Masumoto; Shinnosuke Kimura; Takuya Niijima; Takashi Toyama; Ryoji Kise; Emiko Sato; Yasunori Uchida; Junya Ito; Kiyotaka Nakagawa; Tomohiko Taguchi; Asuka Inoue; Yoshiro Saito; Takuya Noguchi; Atsushi Matsuzawa

  Cell death & disease, 06 Dec. 2024, Peer-reviewed

  
• Signal profiles and spatial regulation of β-arrestin recruitment through Gβ5 and GRK3 at the μ-opioid receptor

  Carlo Marion C. Carino; Suzune Hiratsuka; Ryoji Kise; Gaku Nakamura; Kouki Kawakami; Masataka Yanagawa; Asuka Inoue

  European Journal of Pharmacology, Nov. 2024

  
• Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity.

  Kaito Arai; Yuki Ono; Natsumi Hirai; Yuki Sugiura; Keizo Kaneko; Shigeru Matsuda; Keita Iio; Keita Kajino; Tsuyoshi Saitoh; Fan-Yan Wei; Hideki Katagiri; Asuka Inoue

  Biochimica et biophysica acta. Molecular basis of disease, 12 Nov. 2024

  
• Role of the GRK2/3 N-terminus in discriminating the endocytic effects of opioid agonist drugs.

  Joy Li; Asuka Inoue; Aashish Manglik; Mark von Zastrow

  Molecular pharmacology, 06 Nov. 2024

  
• The repertoire of G-protein-coupled receptor variations in the Japanese population 54KJPN.

  Tatsuya Ikuta; Riko Suzuki; Asuka Inoue

  Genes to cells : devoted to molecular & cellular mechanisms, Nov. 2024

  
• Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells.

  Francesco De Pascali; Asuka Inoue; Jeffrey L Benovic

  The Journal of biological chemistry, 10 Oct. 2024

  
• Cell swelling enhances ligand-driven β-adrenergic signaling.

  Alexei Sirbu; Marc Bathe-Peters; Jothi L M Kumar; Asuka Inoue; Martin J Lohse; Paolo Annibale

  Nature communications, 07 Sep. 2024

  
• Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10.

  Han Yin; Nozomi Kamakura; Yu Qian; Manae Tatsumi; Tatsuya Ikuta; Jiale Liang; Zhenmei Xu; Ruixue Xia; Anqi Zhang; Changyou Guo; Asuka Inoue; Yuanzheng He

  Cell chemical biology, 29 Aug. 2024

  
• Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor.

  Shirsha Saha; Basavraj Khanppnavar; Jagannath Maharana; Heeryung Kim; Carlo Marion C Carino; Carole Daly; Shane Houston; Saloni Sharma; Nashrah Zaidi; Annu Dalal; Sudha Mishra; Manisankar Ganguly; Divyanshu Tiwari; Poonam Kumari; Gagan Deep Jhingan; Prem N Yadav; Bianca Plouffe; Asuka Inoue; Ka Young Chung; Ramanuj Banerjee; Volodymyr M Korkhov; Arun K Shukla

  Cell, 22 Aug. 2024

  
• Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling.

  Yusman Manchanda; Liliane ElEid; Affiong I Oqua; Zenouska Ramchunder; Jiyoon Choi; Maria M Shchepinova; Guy A Rutter; Asuka Inoue; Edward W Tate; Ben Jones; Alejandra Tomas

  Science signaling, 02 Jul. 2024

  
• G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling.

  András D Tóth; Bence Szalai; Orsolya T Kovács; Dániel Garger; Susanne Prokop; Eszter Soltész-Katona; András Balla; Asuka Inoue; Péter Várnai; Gábor Turu; László Hunyady

  Science signaling, 25 Jun. 2024

  
• Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes

  Sazanami Mori; Natsuki Nakamura; Ayane Fuchigami; Satoshi Yoshimoto; Moe Sakakibara; Toshiyuki Ozawa; Junken Aoki; Asuka Inoue; Hayakazu Sumida; Hideya Ando; Motonao Nakamura

  FASEB BioAdvances, 27 Aug. 2024

  
• Molecular mechanism of the endothelin receptor type B interactions with Gs, Gi, and Gq.

  Donghee Ham; Wataru Shihoya; Osamu Nureki; Asuka Inoue; Ka Young Chung

  Structure (London, England : 1993), 15 Jul. 2024

  
• Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.

  Aika Iwama; Ryoji Kise; Hiroaki Akasaka; Fumiya K Sano; Hidetaka S Oshima; Asuka Inoue; Wataru Shihoya; Osamu Nureki

  Nature communications, 19 Jun. 2024

  
• Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide

  Toshiki Yoda; Yasushi Sako; Asuka Inoue; Masataka Yanagawa

  Biophysics and Physicobiology, 2024

  
• A molecular mechanism to diversify Ca²⁺ signaling downstream of Gs protein-coupled receptors

  Julian Brands; Sergi Bravo; Lars Jürgenliemke; Lukas Grätz; Hannes Schihada; Fabian Frechen; Judith Alenfelder; Cy Pfeil; Paul Georg Ohse; Suzune Hiratsuka; Kouki Kawakami; Luna C. Schmacke; Nina Heycke; Asuka Inoue; Gabriele König; Alexander Pfeifer; Dagmar Wachten; Gunnar Schulte; Torsten Steinmetzer; Val J. Watts; Jesús Gomeza; Katharina Simon; Evi Kostenis

  Nature Communications, Dec. 2024

  
• スフィンゴシン-1-リン酸受容体におけるバイアスドアゴニズム機構

  前田 信太郎; 椎村 祐樹; 浅田 秀基; 平田 邦生; Luo Fangjia; 南後 恵理子; 井上 飛鳥; 青木 淳賢; 岩田 想; 萩原 正敏

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• 生理活性物質アンジオテンシンIIの結合によるアンジオテンシンII受容体活性化機構の構造基盤

  浅田 秀基; 井上 飛鳥; Francois Kadji M.N.; 平田 邦生; 椎村 祐樹; Dohyun Im; 青木 淳賢; 岩田 想

  日本生化学会大会プログラム・講演要旨集, Sep. 2019

  
• ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins.

  András Dávid Tóth; Eszter Soltész-Katona; Katalin Kis; Viktor Guti; Sharon Gilzer; Susanne Prokop; Roxána Boros; Ádám Misák; András Balla; Péter Várnai; Lilla Turiák; András Ács; László Drahos; Asuka Inoue; László Hunyady; Gábor Turu

  Cell reports, 16 May 2024

  
• Identification of Gα12-vs-Gα13-coupling determinants and development of a Gα12/13-coupled designer GPCR.

  Manae Tatsumi; Christian Cruz; Nozomi Kamakura; Riku Kuwabara; Gaku Nakamura; Tatsuya Ikuta; Ravinder Abrol; Asuka Inoue

  Scientific reports, 15 May 2024

  
• Therapeutic potentials of nonpeptidic V2R agonists for partial cNDI-causing V2R mutants.

  Ritsuki Kuramoto; Ryoji Kise; Mayu Kanno; Kouki Kawakami; Tatsuya Ikuta; Noriko Makita; Asuka Inoue

  PloS one, 2024

  
• Generation of Comprehensive GPCR-Transducer-Deficient Cell Lines to Dissect the Complexity of GPCR Signaling

  Ayaki Saito; Ryoji Kise; Asuka Inoue

  Pharmacological Reviews, 07 May 2024

  
• Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor.

  Motoki Hoshina; Shiomi Ojima; Atsushi Kawasaki; Kosuke Doi; Satoshi Ohta; Asuka Inoue; Hiroshi Murayama

  Journal of immunological methods, May 2024

  
• GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics.

  Davide Zecchin; Nicole Knöpfel; Anna K Gluck; Mark Stevenson; Aimie Sauvadet; Satyamaanasa Polubothu; Sara Barberan-Martin; Fanourios Michailidis; Dale Bryant; Asuka Inoue; Kate E Lines; Fadil M Hannan; Robert K Semple; Rajesh V Thakker; Veronica A Kinsler

  The Journal of investigative dermatology, Apr. 2024

  
• Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq.

  Donghee Ham; Asuka Inoue; Jun Xu; Yang Du; Ka Young Chung

  Communications biology, 23 Mar. 2024

  
• Identification of oleic acid as an endogenous ligand of GPR3.

  Yangjie Xiong; Zhenmei Xu; Xinzhi Li; Yuqin Wang; Jing Zhao; Na Wang; Yaning Duan; Ruixue Xia; Zhengbin Han; Yu Qian; Jiale Liang; Anqi Zhang; Changyou Guo; Asuka Inoue; Yu Xia; Zheng Chen; Yuanzheng He

  Cell research, Mar. 2024

  
• Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.

  Yueh-Chien Lin; Steven Swendeman; Irina S Moreira; Avishek Ghosh; Andrew Kuo; Nícia Rosário-Ferreira; Shihui Guo; Alan Culbertson; Michel V Levesque; Andreane Cartier; Takahiro Seno; Alec Schmaier; Sylvain Galvani; Asuka Inoue; Samir M Parikh; Garret A FitzGerald; David Zurakowski; Maofu Liao; Robert Flaumenhaft; Zeynep H Gümüş; Timothy Hla

  Science signaling, 20 Feb. 2024

  
• A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling.

  Pauline Raynaud; Vinesh Jugnarain; Océane Vaugrente; Amandine Vallet; Thomas Boulo; Camille Gauthier; Asuka Inoue; Nathalie Sibille; Christophe Gauthier; Frédéric Jean-Alphonse; Eric Reiter; Pascale Crépieux; Gilles Bruneau

  FEBS letters, Jan. 2024

  
• Reply to: How carvedilol does not activate β2-adrenoceptors.

  Evi Kostenis; Jesus Gomeza; Elke Miess-Tanneberg; Nina Kathleen Blum; Tobias Benkel; Andy Chevigné; Carsten Hoffmann; Peter Kolb; Viacheslav Nikolaev; Maria Waldhoer; Martyna Szpakowska; Asuka Inoue; Stefan Schulz

  Nature communications, 30 Nov. 2023

  
• Stepwise phosphorylation of BLT1 defines complex assemblies with β-arrestin serving distinct functions.

  Riko Tatsumi; Saki Aihara; Seiya Matsune; Junken Aoki; Asuka Inoue; Takao Shimizu; Motonao Nakamura

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Nov. 2023

  
• A2B adenosine receptor activation and modulation by protein kinase C.

  Zhan-Guo Gao; Ian M Levitan; Asuka Inoue; Qiang Wei; Kenneth A Jacobson

  iScience, 21 Jul. 2023

  
• Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3.

  Gergő Szanda; Tony Jourdan; Éva Wisniewski; Resat Cinar; Grzegorz Godlewski; Anikó Rajki; Jie Liu; Lee Chedester; Bence Szalai; András Dávid Tóth; Eszter Soltész-Katona; László Hunyady; Asuka Inoue; Viktória Bea Horváth; András Spät; Joseph Tam; George Kunos

  iScience, 21 Jul. 2023

  
• Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms.

  Yufang Deng; Ee Von Moo; Asuka Inoue; Hans Bräuner-Osborne

  FEBS letters, Jun. 2023

  
• Structural basis for activation of CB1 by an endocannabinoid analog.

  Kaavya Krishna Kumar; Michael J Robertson; Elina Thadhani; Haoqing Wang; Carl-Mikael Suomivuori; Alexander S Powers; Lipin Ji; Spyros P Nikas; Ron O Dror; Asuka Inoue; Alexandros Makriyannis; Georgios Skiniotis; Brian Kobilka

  Nature communications, 09 May 2023

  
• Insights into distinct signaling profiles of the µOR activated by diverse agonists.

  Qianhui Qu; Weijiao Huang; Deniz Aydin; Joseph M Paggi; Alpay B Seven; Haoqing Wang; Soumen Chakraborty; Tao Che; Jeffrey F DiBerto; Michael J Robertson; Asuka Inoue; Carl-Mikael Suomivuori; Bryan L Roth; Susruta Majumdar; Ron O Dror; Brian K Kobilka; Georgios Skiniotis

  Nature chemical biology, Apr. 2023

  
• Correction to: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.

  Vinay Kumar Sharma; Xuyu Yang; Soo-Kyung Kim; Amirhossein Mafi; Daniel Saiz-Sanchez; Patricia Villanueva-Anguita; Lan Xiao; Asuka Inoue; William A Goddard 3rd; Y Peng Loh; Leila Toulabi

  Cellular and molecular life sciences : CMLS, 20 Feb. 2023

  
• Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1).

  Fabian Bumbak; Miquel Pons; Asuka Inoue; Juan Carlos Paniagua; Fei Yan; Hongwei Wu; Scott A Robson; Ross A D Bathgate; Daniel J Scott; Paul R Gooley; Joshua J Ziarek

  Cell reports, 31 Jan. 2023

  
• How Carvedilol activates β2-adrenoceptors.

  Tobias Benkel; Mirjam Zimmermann; Julian Zeiner; Sergi Bravo; Nicole Merten; Victor Jun Yu Lim; Edda Sofie Fabienne Matthees; Julia Drube; Elke Miess-Tanneberg; Daniela Malan; Martyna Szpakowska; Stefania Monteleone; Jak Grimes; Zsombor Koszegi; Yann Lanoiselée; Shannon O'Brien; Nikoleta Pavlaki; Nadine Dobberstein; Asuka Inoue; Viacheslav Nikolaev; Davide Calebiro; Andy Chevigné; Philipp Sasse; Stefan Schulz; Carsten Hoffmann; Peter Kolb; Maria Waldhoer; Katharina Simon; Jesus Gomeza; Evi Kostenis

  Nature communications, 19 Nov. 2022

  
• β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells.

  Raphael S Haider; Edda S F Matthees; Julia Drube; Mona Reichel; Ulrike Zabel; Asuka Inoue; Andy Chevigné; Cornelius Krasel; Xavier Deupi; Carsten Hoffmann

  Nature communications, 26 Sep. 2022

  
• Functional rewiring of G protein-coupled receptor signaling in human labor.

  Abigail R Walker; Camilla B Larsen; Samit Kundu; Christina Stavrinidis; Sung Hye Kim; Asuka Inoue; David F Woodward; Yun S Lee; Roberta Migale; David A MacIntyre; Vasso Terzidou; Francesca Fanelli; Shirin Khanjani; Phillip R Bennett; Aylin C Hanyaloglu

  Cell reports, 06 Sep. 2022

  
• Michaelis-Menten Quantification of Ligand Signaling Bias Applied to the Promiscuous Vasopressin V2 Receptor.

  Franziska Marie Heydenreich; Bianca Plouffe; Aurélien Rizk; Dalibor Milić; Joris Zhou; Billy Breton; Christian Le Gouill; Asuka Inoue; Michel Bouvier; Dmitry B Veprintsev

  Molecular pharmacology, Sep. 2022

  
• Agonist-Dependent Coupling of the Promiscuous Adenosine A2B Receptor to Gα Protein Subunits.

  Jan Hendrik Voss; Andhika B Mahardhika; Asuka Inoue; Christa E Müller

  ACS pharmacology & translational science, 13 May 2022

  
• GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.

  Wesley B Asher; Daniel S Terry; G Glenn A Gregorio; Alem W Kahsai; Alessandro Borgia; Bing Xie; Arnab Modak; Ying Zhu; Wonjo Jang; Alekhya Govindaraju; Li-Yin Huang; Asuka Inoue; Nevin A Lambert; Vsevolod V Gurevich; Lei Shi; Robert J Lefkowitz; Scott C Blanchard; Jonathan A Javitch

  Cell, 12 May 2022

  
• OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz.

  Alastair C Keen; Maria Hauge Pedersen; Laura Lemel; Daniel J Scott; Meritxell Canals; Dene R Littler; Travis Beddoe; Yuki Ono; Lei Shi; Asuka Inoue; Jonathan A Javitch; J Robert Lane

  Communications biology, 23 Mar. 2022

  
• Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes.

  Kevin Zheng; Jeffrey S Smith; Dylan S Eiger; Anmol Warman; Issac Choi; Christopher C Honeycutt; Noelia Boldizsar; Jaimee N Gundry; Thomas F Pack; Asuka Inoue; Marc G Caron; Sudarshan Rajagopal

  Science signaling, 22 Mar. 2022

  
• Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin Interaction.

  Michael Ippolito; Francesco De Pascali; Asuka Inoue; Jeffrey L Benovic

  Molecular pharmacology, Feb. 2022

  
• Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.

  Vinay Kumar Sharma; Xuyu Yang; Soo-Kyung Kim; Amirhossein Mafi; Daniel Saiz-Sanchez; Patricia Villanueva-Anguita; Lan Xiao; Asuka Inoue; William A Goddard 3rd; Y Peng Loh

  Cellular and molecular life sciences : CMLS, 29 Dec. 2021

  
• Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.

  Emma Rose McGlone; Yusman Manchanda; Ben Jones; Phil Pickford; Asuka Inoue; David Carling; Stephen R Bloom; Tricia Tan; Alejandra Tomas

  Molecular metabolism, Nov. 2021

  
• Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors.

  Jan H Voss; Jessica Nagel; Muhammad Rafehi; Ramon Guixà-González; Davide Malfacini; Julian Patt; Stefan Kehraus; Asuka Inoue; Gabriele M König; Evi Kostenis; Xavier Deupi; Vigneshwaran Namasivayam; Christa E Müller

  Pharmacological research, Nov. 2021

  
• Loss of β-Arrestins or six Gα proteins in HEK293 cells caused Warburg effect and prevented progesterone-induced rapid proteasomal degradation of progesterone receptor membrane component 1.

  Mohammad Golam Sabbir; Asuka Inoue; Carla G Taylor; Peter Zahradka

  The Journal of steroid biochemistry and molecular biology, Nov. 2021

  
• Corrigendum to "BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes" [Biochem. Pharmacol. 158 (2108) 232-242].

  Shannon L O'Brien; Elizabeth K M Johnstone; Dominic Devost; Jacinta Conroy; Melissa E Reichelt; Brooke W Purdue; Mohammed A Ayoub; Tatsuo Kawai; Asuka Inoue; Satoru Eguchi; Terence E Hébert; Kevin D G Pfleger; Walter G Thomas

  Biochemical pharmacology, Oct. 2021

  
• Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor.

  Francesco De Pascali; Mohammed Akli Ayoub; Riccardo Benevelli; Silvia Sposini; Jordan Lehoux; Nathalie Gallay; Pauline Raynaud; Flavie Landomiel; Frédéric Jean-Alphonse; Christophe Gauthier; Lucie P Pellissier; Pascale Crépieux; Anne Poupon; Asuka Inoue; Nicolas Joubert; Marie-Claude Viaud-Massuard; Livio Casarini; Manuela Simoni; Aylin C Hanyaloglu; Selva G Nataraja; Henry N Yu; Stephen S Palmer; Romain Yvinec; Eric Reiter

  International journal of molecular sciences, 12 Sep. 2021

  
• Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors.

  Ulla Seibel-Ehlert; Nicole Plank; Asuka Inoue; Guenther Bernhardt; Andrea Strasser

  International journal of molecular sciences, 09 Sep. 2021

  
• Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.

  Misa Sayama; Akiharu Uwamizu; Masaya Ikubo; Luying Chen; Ge Yan; Yuko Otani; Asuka Inoue; Junken Aoki; Tomohiko Ohwada

  Journal of medicinal chemistry, 22 Jul. 2021

  
• Heterogeneity of G protein activation by the calcium-sensing receptor.

  Hasnat Ali Abid; Asuka Inoue; Caroline M Gorvin

  Journal of molecular endocrinology, 21 Jun. 2021

  
• Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.

  Mette Trauelsen; Thomas K Hiron; Da Lin; Jacob E Petersen; Billy Breton; Anna Sofie Husted; Siv A Hjorth; Asuka Inoue; Thomas M Frimurer; Michel Bouvier; Chris A O'Callaghan; Thue W Schwartz

  Cell reports, 15 Jun. 2021

  
• Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors.

  Jeffrey S Smith; Thomas F Pack; Asuka Inoue; Claudia Lee; Kevin Zheng; Issac Choi; Dylan S Eiger; Anmol Warman; Xinyu Xiong; Zhiyuan Ma; Gayathri Viswanathan; Ian M Levitan; Lauren K Rochelle; Dean P Staus; Joshua C Snyder; Alem W Kahsai; Marc G Caron; Sudarshan Rajagopal

  Science (New York, N.Y.), 12 Mar. 2021

  
• Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2.

  Natalia V Ortiz Zacarías; Kirti K Chahal; Tereza Šimková; Cas van der Horst; Yi Zheng; Asuka Inoue; Emy Theunissen; Lloyd Mallee; Daan van der Es; Julien Louvel; Adriaan P IJzerman; Tracy M Handel; Irina Kufareva; Laura H Heitman

  Journal of medicinal chemistry, 11 Mar. 2021

  
• An experimental strategy to probe Gq contribution to signal transduction in living cells.

  Julian Patt; Judith Alenfelder; Eva Marie Pfeil; Jan Hendrik Voss; Nicole Merten; Funda Eryilmaz; Nina Heycke; Uli Rick; Asuka Inoue; Stefan Kehraus; Xavier Deupi; Christa E Müller; Gabriele M König; Max Crüsemann; Evi Kostenis

  The Journal of biological chemistry, 2021

  
• A novel luminescence-based β-arrestin recruitment assay for unmodified receptors.

  Maria Hauge Pedersen; Jennifer Pham; Helena Mancebo; Asuka Inoue; Wesley B Asher; Jonathan A Javitch

  The Journal of biological chemistry, 2021

  
• Constitutive G protein coupling profiles of understudied orphan GPCRs.

  Sumin Lu; Wonjo Jang; Asuka Inoue; Nevin A Lambert

  PloS one, 2021

  
• Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.

  Signe Mathiasen; Tiago Palmisano; Nicole A Perry; Hannah M Stoveken; Alex Vizurraga; Dyke P McEwen; Najeah Okashah; Tobias Langenhan; Asuka Inoue; Nevin A Lambert; Gregory G Tall; Jonathan A Javitch

  Nature chemical biology, Dec. 2020

  
• CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2.

  Huong Thi Nguyen; Arfaxad Reyes-Alcaraz; Hyo Jeong Yong; Lan Phuong Nguyen; Hee-Kyung Park; Asuka Inoue; Cheol Soon Lee; Jae Young Seong; Jong-Ik Hwang

  Cell & bioscience, 23 Nov. 2020

  
• Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.

  Ali Işbilir; Jan Möller; Marta Arimont; Vladimir Bobkov; Cristina Perpiñá-Viciano; Carsten Hoffmann; Asuka Inoue; Raimond Heukers; Chris de Graaf; Martine J Smit; Paolo Annibale; Martin J Lohse

  Proceedings of the National Academy of Sciences of the United States of America, 17 Nov. 2020

  
• Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release.

  Natarin Caengprasath; Noemi Gonzalez-Abuin; Maria Shchepinova; Yue Ma; Asuka Inoue; Edward W Tate; Gary Frost; Aylin C Hanyaloglu

  iScience, 25 Sep. 2020

  
• GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11.

  Dayana Abboud; Adrian F Daly; Nadine Dupuis; Mohamed Ali Bahri; Asuka Inoue; Andy Chevigné; Fabien Ectors; Alain Plenevaux; Bernard Pirotte; Albert Beckers; Julien Hanson

  Nature communications, 21 Sep. 2020

  
• A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels.

  Kosuke Doi; Kouki Kawakami; Tatsuya Ikuta; Asuka Inoue

  Scientific reports, 24 Apr. 2024

  
• GPCRとβアレスチンの結合多様性と機能的役割の解析

  中村 楽; 桑原 莉来; 川上 耕季; 井上 飛鳥

  日本生化学会大会プログラム・講演要旨集, Oct. 2023

  
• 遊離脂肪酸受容体(FFAR)の脂肪酸受容における鎖長選択性の解明

  九川 真衣; 木瀬 亮次; 福田 昌弘; 川上 耕季; 松井 俊貴; 小林 和弘; 井上 飛鳥; 加藤 英明

  日本生化学会大会プログラム・講演要旨集, Oct. 2023

  
• レポーターアッセイを用いたGPCRシグナルネットワークの解明

  齋藤 郁貴; 木瀬 亮次; 川上 耕季; 井上 飛鳥

  日本生化学会大会プログラム・講演要旨集, Oct. 2023

  
• Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.

  Keita Iio; Noriki Kutsumura; Yasuyuki Nagumo; Tsuyoshi Saitoh; Akihisa Tokuda; Kao Hashimoto; Naoshi Yamamoto; Ryoji Kise; Asuka Inoue; Hirokazu Mizoguchi; Hiroshi Nagase

  Bioorganic & Medicinal Chemistry Letters, 15 Jan. 2022, Peer-reviewed

  
• Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate.

  Masumi Oka; Sohta Akaki; Osamu Ohno; Maho Terasaki; Yuho Hamaoka-Tamura; Michiko Saito; Shinichi Kato; Asuka Inoue; Junken Aoki; Kenji Matsuno; Kazuyuki Furuta; Satoshi Tanaka

  The Journal of pharmacology and experimental therapeutics, 15 Mar. 2024

  
• Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor.

  Tharindunee Jayakody; Asuka Inoue; Srinivasaraghavan Kannan; Gaku Nakamura; Kouki Kawakami; Krishan Mendis; Thanh-Binh Nguyen; Jianguo Li; Deron R Herr; Chandra S Verma; Gavin S Dawe

  Science signaling, 13 Feb. 2024

  
• GPCR signaling bias: an emerging framework for opioid drug development

  Ryoji Kise; Asuka Inoue

  The Journal of Biochemistry, 02 Feb. 2024

  
• Basal interaction of the orphan receptor GPR101 with arrestins leads to constitutive internalization

  Dayana Abboud; Clauda Abboud; Asuka Inoue; Jean-Claude Twizere; Julien Hanson

  Biochemical Pharmacology, Feb. 2024

  
• Structural and functional characterization of the endogenous agonist for orphan receptor GPR3

  Geng Chen; Nico Staffen; Zhangsong Wu; Xinyu Xu; Jinheng Pan; Asuka Inoue; Tingyi Shi; Peter Gmeiner; Yang Du; Jun Xu

  Cell Research, 30 Jan. 2024

  
• Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

  Thor C. Møller; Ee Von Moo; Asuka Inoue; Mie F. Pedersen; Hans Bräuner-Osborne

  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Jan. 2024

  
• Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy

  Kayo Imamura; Ken-Ichi Akagi; Yohei Miyanoiri; Hirokazu Tsujimoto; Takatsugu Hirokawa; Hideo Ashida; Kaori Murakami; Asuka Inoue; Ryoji Suno; Takahisa Ikegami; Naotaka Sekiyama; So Iwata; Takuya Kobayashi; Hidehito Tochio

  Structure, Jan. 2024

  
• Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.

  Jae-Hyun Park; Kouki Kawakami; Naito Ishimoto; Tatsuya Ikuta; Mio Ohki; Toru Ekimoto; Mitsunori Ikeguchi; Dong-Sun Lee; Young-Ho Lee; Jeremy R H Tame; Asuka Inoue; Sam-Yong Park

  Nature communications, 06 Nov. 2023

  
• Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

  Valeria Burghi; Justine S. Paradis; Adam Officer; Sendi Rafael Adame-Garcia; Xingyu Wu; Edda S.F. Matthees; Benjamin Barsi-Rhyne; Dana J. Ramms; Lauren Clubb; Monica Acosta; Pablo Tamayo; Michel Bouvier; Asuka Inoue; Mark von Zastrow; Carsten Hoffmann; J. Silvio Gutkind

  Journal of Biological Chemistry, Nov. 2023

  
• G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.

  Naoto Kajitani; Mami Okada-Tsuchioka; Asuka Inoue; Kanako Miyano; Takeshi Masuda; Shuken Boku; Kazuya Iwamoto; Sumio Ohtsuki; Yasuhito Uezono; Junken Aoki; Minoru Takebayashi

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 06 Sep. 2023

  
• Eriodictyol and thymonin act as GPR35 agonists

  Fumie Nakashima; Wei Qi Loh; Mayuka Wakabayashi; Sayako Shimomura; Hiroyuki Hattori; Masaki Kita; Asuka Inoue; Koji Uchida; Takahiro Shibata

  Bioscience, Biotechnology, and Biochemistry, 04 Sep. 2023

  
• Chemogenetic activation of G12 signaling enhances adipose tissue browning.

  Yuki Ono; Ryo Ito; Kaito Arai; Gurdeep Singh; Tsuyoshi Saitoh; Robert B Russell; Francesco Raimondi; Junken Aoki; Juro Sakai; Asuka Inoue

  Signal transduction and targeted therapy, 21 Aug. 2023

  
• Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system.

  Parishmita Sarma; Carlo Marion C Carino; Deeksha Seetharama; Shubhi Pandey; Hemlata Dwivedi-Agnihotri; Xue Rui; Yubo Cao; Kouki Kawakami; Poonam Kumari; Yu-Chih Chen; Kathryn E Luker; Prem N Yadav; Gary D Luker; Stéphane A Laporte; Xin Chen; Asuka Inoue; Arun K Shukla

  Nature communications, 09 Aug. 2023

  
• GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach

  Marin Matic; Pasquale Miglionico; Manae Tatsumi; Asuka Inoue; Francesco Raimondi

  Nature Communications, 19 Jul. 2023

  
• Structural basis of CXC chemokine receptor 1 ligand binding and activation.

  Naito Ishimoto; Jae-Hyun Park; Kouki Kawakami; Michiko Tajiri; Kenji Mizutani; Satoko Akashi; Jeremy R H Tame; Asuka Inoue; Sam-Yong Park

  Nature communications, 11 Jul. 2023

  
• Transcriptome Profiling of Anhidrotic Eccrine Sweat Glands Reveals that Olfactory Receptors on Eccrine Sweat Glands Regulate Perspiration in a Ligand-Dependent Manner

  Naoya Murayama; Takafumi Miyaki; Daisuke Okuzaki; Yasuaki Shibata; Takehiko Koji; Asuka Inoue; Junken Aoki; Hideki Hayashi; Yoshimasa Tanaka; Hiroyuki Murota

  JID Innovations, Jul. 2023

  
• Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

  Fabian Bumbak; James B. Bower; Skylar C. Zemmer; Asuka Inoue; Miquel Pons; Juan Carlos Paniagua; Fei Yan; James Ford; Hongwei Wu; Scott A. Robson; Ross A. D. Bathgate; Daniel J. Scott; Paul R. Gooley; Joshua J. Ziarek

  Nature Communications, 07 Jun. 2023

  
• Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity

  Han Yin; Asuka Inoue; Zhengxiong Ma; Xinyan Zhu; Ruixue Xia; Zhenmei Xu; Na Wang; Yaning Duan; Anqi Zhang; Changyou Guo; Yuanzheng He

  Cell Research, 07 Jun. 2023

  
• Class B1 GPCR activation by an intracellular agonist.

  Kazuhiro Kobayashi; Kouki Kawakami; Tsukasa Kusakizako; Atsuhiro Tomita; Michihiro Nishimura; Kazuhiro Sawada; Hiroyuki H Okamoto; Suzune Hiratsuka; Gaku Nakamura; Riku Kuwabara; Hiroshi Noda; Hiroyasu Muramatsu; Masaru Shimizu; Tomohiko Taguchi; Asuka Inoue; Takeshi Murata; Osamu Nureki

  Nature, 07 Jun. 2023

  
• Molecular mechanism of fatty acid activation of FFAR1

  Punita Kumari; Asuka Inoue; Karen Chapman; Peng Lian; Daniel M. Rosenbaum

  Proceedings of the National Academy of Sciences, 22 May 2023

  
• Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.

  Akiko Ogawa; Seiya Ohira; Yuri Kato; Tatsuya Ikuta; Shota Yanagida; Xinya Mi; Yukina Ishii; Yasunari Kanda; Motohiro Nishida; Asuka Inoue; Fan-Yan Wei

  Communications biology, 12 May 2023

  
• Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation

  Eisho Kanemitsu; Xiangdong Zhao; Keiko Iwaisako; Asuka Inoue; Akihide Takeuchi; Shintaro Yagi; Hidetoshi Masumoto; Hiroaki Ohara; Motoyasu Hosokawa; Tomonari Awaya; Junken Aoki; Etsuro Hatano; Shinji Uemoto; Masatoshi Hagiwara

  Translational Research, May 2023

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• Design and Synthesis of Orexin 1 Receptor-Selective Agonists

  Keita Iio; Kao Hashimoto; Yasuyuki Nagumo; Mao Amezawa; Taisei Hasegawa; Naoshi Yamamoto; Noriki Kutsumura; Katsuhiko Takeuchi; Yukiko Ishikawa; Hikari Yamamoto; Akihisa Tokuda; Tetsu Sato; Yasuo Uchida; Asuka Inoue; Ryuji Tanimura; Masashi Yanagisawa; Hiroshi Nagase; Tsuyoshi Saitoh

  Journal of Medicinal Chemistry, 12 Apr. 2023

  
• Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.

  Jie Heng; Yunfei Hu; Guillermo Pérez-Hernández; Asuka Inoue; Jiawei Zhao; Xiuyan Ma; Xiaoou Sun; Kouki Kawakami; Tatsuya Ikuta; Jienv Ding; Yujie Yang; Lujia Zhang; Sijia Peng; Xiaogang Niu; Hongwei Li; Ramon Guixà-González; Changwen Jin; Peter W Hildebrand; Chunlai Chen; Brian K Kobilka

  Nature communications, 10 Apr. 2023

  
• Exploration of LPS2 agonist binding modes using the combination of a new hydrophobic scaffold and homology modeling.

  Luying Chen; Akiharu Uwamizu; Misa Sayama; Kuniyuki Kano; Yuko Otani; Sho Kondo; Asuka Inoue; Junken Aoki; Tomohiko Ohwada

  European journal of medicinal chemistry, 05 Apr. 2023

  
• Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization

  Viktoria M. S. Kjær; Viktorija Daugvilaite; Tomasz M. Stepniewski; Christian M. Madsen; Astrid S. Jørgensen; Kaustubh R. Bhuskute; Asuka Inoue; Trond Ulven; Tau Benned-Jensen; Siv A. Hjorth; Gertrud M. Hjortø; Ee Von Moo; Jana Selent; Mette M. Rosenkilde

  Science Signaling, 04 Apr. 2023

  
• Phosphorylation barcodes direct biased chemokine signaling at CXCR3.

  Dylan S Eiger; Jeffrey S Smith; Tujin Shi; Tomasz Maciej Stepniewski; Chia-Feng Tsai; Christopher Honeycutt; Noelia Boldizsar; Julia Gardner; Carrie D Nicora; Ahmed M Moghieb; Kouki Kawakami; Issac Choi; Chloe Hicks; Kevin Zheng; Anmol Warman; Priya Alagesan; Nicole M Knape; Ouwen Huang; Justin D Silverman; Richard D Smith; Asuka Inoue; Jana Selent; Jon M Jacobs; Sudarshan Rajagopal

  Cell chemical biology, 03 Apr. 2023

  
• Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors

  Jan H. Voss; Max Crüsemann; Christian R.O. Bartling; Stefan Kehraus; Asuka Inoue; Gabriele M. König; Kristian Strømgaard; Christa E. Müller

  iScience, Apr. 2023

  
• Phosphorylation barcodes direct biased chemokine signaling at CXCR3.

  Dylan S Eiger; Jeffrey S Smith; Tujin Shi; Tomasz Maciej Stepniewski; Chia-Feng Tsai; Christopher Honeycutt; Noelia Boldizsar; Julia Gardner; Carrie D Nicora; Ahmed M Moghieb; Kouki Kawakami; Issac Choi; Kevin Zheng; Anmol Warman; Priya Alagesan; Nicole M Knape; Ouwen Huang; Justin D Silverman; Richard D Smith; Asuka Inoue; Jana Selent; Jon M Jacobs; Sudarshan Rajagopal

  bioRxiv : the preprint server for biology, 14 Mar. 2023

  
• Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase.

  Sho Furumura; Taro Ozaki; Akihiro Sugawara; Yohei Morishita; Kento Tsukada; Tatsuya Ikuta; Asuka Inoue; Teigo Asai

  Journal of natural products, 24 Feb. 2023

  
• Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.

  Jiale Liang; Asuka Inoue; Tatsuya Ikuta; Ruixue Xia; Na Wang; Kouki Kawakami; Zhenmei Xu; Yu Qian; Xinyan Zhu; Anqi Zhang; Changyou Guo; Zhiwei Huang; Yuanzheng He

  Nature communications, 23 Feb. 2023

  
• Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.

  Yuki Ono; Kouki Kawakami; Gaku Nakamura; Satoru Ishida; Junken Aoki; Asuka Inoue

  Communications biology, 28 Jan. 2023

  
• Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84

  Ryuji Ohue-Kitano; Hazuki Nonaka; Akari Nishida; Yuki Masujima; Daisuke Takahashi; Takako Ikeda; Akiharu Uwamizu; Miyako Tanaka; Motoyuki Kohjima; Miki Igarashi; Hironori Katoh; Tomohiro Tanaka; Asuka Inoue; Takayoshi Suganami; Koji Hase; Yoshihiro Ogawa; Junken Aoki; Ikuo Kimura

  JCI Insight, 24 Jan. 2023

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• Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.

  Jun Xu; Qinggong Wang; Harald Hübner; Yunfei Hu; Xiaogang Niu; Haoqing Wang; Shoji Maeda; Asuka Inoue; Yuyong Tao; Peter Gmeiner; Yang Du; Changwen Jin; Brian K Kobilka

  Nature communications, 23 Jan. 2023

  
• Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity.

  Masaya Ikubo; Akiharu Uwamizu; Luying Chen; Sho Nakamura; Misa Sayama; Hiroki Kawana; Yuko Otani; Kuniyuki Kano; Asuka Inoue; Junken Aoki; Tomohiko Ohwada

  Chemical & pharmaceutical bulletin, 2023

  
• Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.

  Manae Tatsumi; Takayuki Kishi; Satoru Ishida; Hiroki Kawana; Akiharu Uwamizu; Yuki Ono; Kouki Kawakami; Junken Aoki; Asuka Inoue

  PloS one, 2023

  
• Constitutively active GPR43 is crucial for proper leukocyte differentiation.

  Sosuke Miyasato; Kurumi Iwata; Reika Mura; Shou Nakamura; Keisuke Yanagida; Hideo Shindou; Yosuke Nagata; Masahiro Kawahara; Satoshi Yamaguchi; Junken Aoki; Asuka Inoue; Teruyuki Nagamune; Takao Shimizu; Motonao Nakamura

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan. 2023

  
• Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

  Mithu Baidya; Madhu Chaturvedi; Hemlata Dwivedi-Agnihotri; Ashutosh Ranjan; Dominic Devost; Yoon Namkung; Tomasz Maciej Stepniewski; Shubhi Pandey; Minakshi Baruah; Bhanupriya Panigrahi; Parishmita Sarma; Manish K. Yadav; Jagannath Maharana; Ramanuj Banerjee; Kouki Kawakami; Asuka Inoue; Jana Selent; Stéphane A. Laporte; Terence E. Hébert; Arun K. Shukla

  Nature Communications, Dec. 2022

  
• Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

  Kouki Kawakami; Masataka Yanagawa; Suzune Hiratsuka; Misaki Yoshida; Yuki Ono; Michio Hiroshima; Masahiro Ueda; Junken Aoki; Yasushi Sako; Asuka Inoue

  Nature Communications, 25 Jan. 2022

  
• Control of Gαq signaling dynamics and GPCR cross-talk by GRKs.

  Guoqing Xiang; Amanda Acosta-Ruiz; Arthur Radoux-Mergault; Melanie Kristt; Jihye Kim; Jared D Moon; Johannes Broichhagen; Asuka Inoue; Francis S Lee; Miriam Stoeber; Jeremy S Dittman; Joshua Levitz

  Science advances, 25 Nov. 2022

  
• Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

  John Janetzko; Ryoji Kise; Benjamin Barsi-Rhyne; Dirk H. Siepe; Franziska M. Heydenreich; Kouki Kawakami; Matthieu Masureel; Shoji Maeda; K. Christopher Garcia; Mark von Zastrow; Asuka Inoue; Brian K. Kobilka

  Cell, 23 Nov. 2022

  
• Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890.

  Clinita E Randolph; Morgan B Dwyer; Jenna L Aumiller; Alethia J Dixon; Asuka Inoue; Patrick Osei-Owusu; Philip B Wedegaertner

  The Journal of biological chemistry, Nov. 2022

  
• マルチレイヤー解析技術によるシグナル伝達-生命現象の解読 オピオイド受容体のシグナル解読とバイアス型リガンドによる自在制御

  川上 耕季; 生田 達也; 井上 飛鳥

  日本生化学会大会プログラム・講演要旨集, Nov. 2022

  
• PTH1受容体における内在性リガンドの認識機構と構造ダイナミクス

  小林 和弘; 川上 耕季; 草木迫 司; 郷野 弘剛; 富田 敦弘; 小林 幹; 志甫谷 渉; 山下 恵太郎; 西澤 知宏; 加藤 英明; 井上 飛鳥; 濡木 理

  日本生化学会大会プログラム・講演要旨集, Nov. 2022

  
• Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex

  Ryoji Suno; Yukihiko Sugita; Kazushi Morimoto; Hiroko Takazaki; Hirokazu Tsujimoto; Mika Hirose; Chiyo Suno-Ikeda; Norimichi Nomura; Tomoya Hino; Asuka Inoue; Kenji Iwasaki; Takayuki Kato; So Iwata; Takuya Kobayashi

  Cell Reports, Sep. 2022

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• Endogenous ligand recognition and structural transition of a human PTH receptor.

  Kazuhiro Kobayashi; Kouki Kawakami; Tsukasa Kusakizako; Hirotake Miyauchi; Atsuhiro Tomita; Kan Kobayashi; Wataru Shihoya; Keitaro Yamashita; Tomohiro Nishizawa; Hideaki E Kato; Asuka Inoue; Osamu Nureki

  Molecular cell, 04 Aug. 2022

  
• クライオ電子顕微鏡によるヒト由来メラトニン受容体シグナル伝達複合体の立体構造解析(Cryo-EM structure of the human MT1-Gi signaling complex)

  Okamoto Hiroyuki; Miyauchi Hirotake; Inoue Asuka; Raimondi Francesco; Tsujimoto Hirokazu; Kusakizako Tsukasa; Shihoya Wataru; Yamashita Keitaro; Suno Ryoji; Nomura Norimichi; Kobayashi Takuya; Iwata So; Nishizawa Tomohiro; Nureki Osamu

  生物物理, Aug. 2022

  
• Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.

  Yunseok Heo; Naito Ishimoto; Ye-Eun Jeon; Ji-Hye Yun; Mio Ohki; Yuki Anraku; Mina Sasaki; Shunsuke Kita; Hideo Fukuhara; Tatsuya Ikuta; Kouki Kawakami; Asuka Inoue; Katsumi Maenaka; Jeremy R H Tame; Weontae Lee; Sam-Yong Park

  PLoS biology, Aug. 2022

  
• Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol.

  Ikko Nureki; Kazuhiro Kobayashi; Tatsuki Tanaka; Kanae Demura; Asuka Inoue; Wataru Shihoya; Osamu Nureki

  Biochemical and biophysical research communications, 30 Jun. 2022

  
• Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble.

  Austin D Dixon; Asuka Inoue; Scott A Robson; Kelly J Culhane; Jonathan C Trinidad; Sivaraj Sivaramakrishnan; Fabian Bumbak; Joshua J Ziarek

  Journal of the American Chemical Society, 15 Jun. 2022

  
• PRECOGx: exploring GPCR signaling mechanisms with deep protein representations.

  Marin Matic; Gurdeep Singh; Francesco Carli; Natalia De Oliveira Rosa; Pasquale Miglionico; Lorenzo Magni; J Silvio Gutkind; Robert B Russell; Asuka Inoue; Francesco Raimondi

  Nucleic acids research, 26 May 2022

  
• Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.

  Chayma El Khamlichi; Flora Reverchon; Nadège Hervouet-Coste; Elodie Robin; Nicolas Chopin; Emmanuel Deau; Fahima Madouri; Cyril Guimpied; Cyril Colas; Arnaud Menuet; Asuka Inoue; Andrzej J Bojarski; Gérald Guillaumet; Franck Suzenet; Eric Reiter; Séverine Morisset-Lopez

  Proceedings of the National Academy of Sciences of the United States of America, 24 May 2022

  
• Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish.

  Takeaki Shibata; Hiroki Kawana; Yuri Nishino; Yoshiko Ito; Hiroyasu Sato; Hirofumi Onishi; Kuniyuki Kano; Asuka Inoue; Yoshitaka Taketomi; Makoto Murakami; Satoshi Kofuji; Hiroshi Nishina; Atsuo Miyazawa; Nozomu Kono; Junken Aoki

  Scientific reports, 04 May 2022

  
• Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.

  Geng Chen; Jun Xu; Asuka Inoue; Maximilian F Schmidt; Chen Bai; Qiuyuan Lu; Peter Gmeiner; Zheng Liu; Yang Du

  Nature communications, 02 May 2022

  
• Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non-redundant chemokine signaling

  Dylan S. Eiger; Jeffrey Smith; Tujin Shi; Tomasz M. Stepniewski; Christopher Honeycutt; Noelia Boldizsar; Julia Gardner; Chia Feng Tsai; Carrie Nicora; Ahmed Moghieb; Kouki Kawakami; Issac Choi; Richard Smith; Asuka Inoue; Jana Selent; Jon Jacobs; Sudarshan Rajagopal

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 01 May 2022

  
• Phenotypic evaluation of constitutive GPCR/G-protein signaling in zebrafish embryos and larvae

  Takeaki Shibata; Kouki Kawakami; Hiroki Kawana; Junken Aoki; Asuka Inoue

  Biochemical and Biophysical Research Communications, Apr. 2022

  
• Common coupling map advances GPCR-G protein selectivity.

  Alexander S Hauser; Charlotte Avet; Claire Normand; Arturo Mancini; Asuka Inoue; Michel Bouvier; David E Gloriam

  eLife, 18 Mar. 2022

  
• Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma

  Kai Kudo; Yoshimi Miki; Joaquim Carreras; Shunya Nakayama; Yasushi Nakamoto; Masatoshi Ito; Etsuko Nagashima; Kei Yamamoto; Hiroshi Higuchi; Shin-ya Morita; Asuka Inoue; Junken Aoki; Kiyoshi Ando; Naoya Nakamura; Makoto Murakami; Ai Kotani

  Cell Metabolism, Mar. 2022

  
• βアレスチンの結合様式と機能の包括的理解

  倉本 律輝; 川上 耕季; 生田 達也; 桑原 莉来; 吉田 美沙紀; 井上 飛鳥

  日本薬学会年会要旨集, Mar. 2022

  
• Author Correction: Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism (Nature Chemical Biology, (2022), 18, 3, (281-288), 10.1038/s41589-021-00930-3)

  Zhenmei Xu; Tatsuya Ikuta; Kouki Kawakami; Ryoji Kise; Yu Qian; Ruixue Xia; Ming Xia Sun; Anqi Zhang; Changyou Guo; Xue Hui Cai; Zhiwei Huang; Asuka Inoue; Yuanzheng He

  Nature Chemical Biology, Mar. 2022

  
• Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.

  Takahiro Nagatake; Shigenobu Kishino; Emiko Urano; Haruka Murakami; Nahoko Kitamura; Kana Konishi; Harumi Ohno; Prabha Tiwari; Sakiko Morimoto; Eri Node; Jun Adachi; Yuichi Abe; Junko Isoyama; Kento Sawane; Tetsuya Honda; Asuka Inoue; Akiharu Uwamizu; Takashi Matsuzaka; Yoichi Miyamoto; So-Ichiro Hirata; Azusa Saika; Yuki Shibata; Koji Hosomi; Ayu Matsunaga; Hitoshi Shimano; Makoto Arita; Junken Aoki; Masahiro Oka; Akira Matsutani; Takeshi Tomonaga; Kenji Kabashima; Motohiko Miyachi; Yasuhiro Yasutomi; Jun Ogawa; Jun Kunisawa

  Mucosal immunology, Feb. 2022

  
• Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.

  Rieko Suenaga; Mizuki Takemoto; Asuka Inoue; Ryuichiro Ishitani; Osamu Nureki

  PloS one, 2022

  
• Structural transition of human PTH1R revealed distinct molecular recognition and molecular switch for sustainable activation

  Kazuhiro Kobayashi; Kawakami Kouki; Kusakizako Tshukasa; Gono Hirotake; Tomita Atsuhiro; Kobayashi Kan; Shihoya Wataru; Yamashita Keitaro; Nishizawa Tomohiro; Kato Hideaki; Inoue Asuka; Nureki Osamu

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022

  
• An intrabody sensor to monitor conformational activation of β-arrestins

  Hemlata Dwivedi-Agnihotri; Parishmita Sarma; S. Deeksha; Kouki Kawakami; Asuka Inoue; Arun K. Shukla

  Methods in Cell Biology, 2022

  
• Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism

  Zhenmei Xu; Tatsuya Ikuta; Kouki Kawakami; Ryoji Kise; Yu Qian; Ruixue Xia; Ming-Xia Sun; Anqi Zhang; Changyou Guo; Xue-Hui Cai; Zhiwei Huang; Asuka Inoue; Yuanzheng He

  Nature Chemical Biology, 22 Dec. 2021

  
• Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R).

  Kota Katayama; Kohei Suzuki; Ryoji Suno; Ryoji Kise; Hirokazu Tsujimoto; So Iwata; Asuka Inoue; Takuya Kobayashi; Hideki Kandori

  Communications biology, 23 Nov. 2021

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• An ATX-LPA6-Gα13-ROCK axis shapes and maintains caudal vein plexus in zebrafish.

  Ryohei Okasato; Kuniyuki Kano; Ryoji Kise; Asuka Inoue; Shigetomo Fukuhara; Junken Aoki

  iScience, 19 Nov. 2021

  
• 選択的薬剤が結合したbeta3アドレナリン受容体の構造

  志甫谷 渉; 名切 千彩恵; 井上 飛鳥; 濡木 理

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics

  John Janetzko; Ryoji Kise; Benjamin Barsi-Ryne; Dirk H. Siepe; Franziska M. Heydenreich; Matthieu Masureel; Kouki Kawakami; K. Christopher Garcia; Mark von Zastrow; Asuka Inoue; Brian K. Kobilka

  10 Oct. 2021

  
• Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.

  Chisae Nagiri; Kazuhiro Kobayashi; Atsuhiro Tomita; Masahiko Kato; Kan Kobayashi; Keitaro Yamashita; Tomohiro Nishizawa; Asuka Inoue; Wataru Shihoya; Osamu Nureki

  Molecular cell, 05 Aug. 2021

  
• Cryo-EM structure of the human MT1–Gi signaling complex

  Hiroyuki H. Okamoto; Hirotake Miyauchi; Asuka Inoue; Francesco Raimondi; Hirokazu Tsujimoto; Tsukasa Kusakizako; Wataru Shihoya; Keitaro Yamashita; Ryoji Suno; Norimichi Nomura; Takuya Kobayashi; So Iwata; Tomohiro Nishizawa; Osamu Nureki

  Nature Structural & Molecular Biology, 05 Aug. 2021

  
• Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.

  Shintaro Maeda; Yuki Shiimura; Hidetsugu Asada; Kunio Hirata; Fangjia Luo; Eriko Nango; Nobuo Tanaka; Masayasu Toyomoto; Asuka Inoue; Junken Aoki; So Iwata; Masatoshi Hagiwara

  Science advances, Jun. 2021

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• Smoothened transduces hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

  Corvin D. Arveseth; John T. Happ; Danielle S. Hedeen; Ju Fen Zhu; Jacob L. Capener; Dana Klatt Shaw; Ishan Deshpande; Jiahao Liang; Jiewei Xu; Sara L. Stubben; Isaac B. Nelson; Madison F. Walker; Kouki Kawakami; Asuka Inoue; Nevan J. Krogan; David J. Grunwald; Ruth Hüttenhain; Aashish Manglik; Benjamin R. Myers

  PLoS Biology, Apr. 2021

  
• N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand.

  Akiko Ogawa; Chisae Nagiri; Wataru Shihoya; Asuka Inoue; Kouki Kawakami; Suzune Hiratsuka; Junken Aoki; Yasuhiro Ito; Takeo Suzuki; Tsutomu Suzuki; Toshihiro Inoue; Osamu Nureki; Hidenobu Tanihara; Kazuhito Tomizawa; Fan-Yan Wei

  Molecular cell, 18 Feb. 2021

  
• Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

  Shubhi Pandey; Punita Kumari; Mithu Baidya; Ryoji Kise; Yubo Cao; Hemlata Dwivedi-Agnihotri; Ramanuj Banerjee; Xaria X. Li; Cedric S. Cui; John D. Lee; Kouki Kawakami; Madhu Chaturvedi; Ashutosh Ranjan; Stéphane A. Laporte; Trent M. Woodruff; Asuka Inoue; Arun K. Shukla

  Molecular cell, 02 Feb. 2021

  
• S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell chemical biology, 02 Feb. 2021

  
• Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359.

  Cornelia Hermes; René Richarz; Daniel A Wirtz; Julian Patt; Wiebke Hanke; Stefan Kehraus; Jan Hendrik Voß; Jim Küppers; Tsubasa Ohbayashi; Vigneshwaran Namasivayam; Judith Alenfelder; Asuka Inoue; Peter Mergaert; Michael Gütschow; Christa E Müller; Evi Kostenis; Gabriele M König; Max Crüsemann

  Nature communications, 08 Jan. 2021

  
• Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors

  Ben Jones; Emma Rose McGlone; Zijian Fang; Phil Pickford; Ivan R. Corrêa; Atsuro Oishi; Ralf Jockers; Asuka Inoue; Sunil Kumar; Frederik Görlitz; Chris Dunsby; Paul M.W. French; Guy A. Rutter; Tricia Tan; Alejandra Tomas; Stephen R. Bloom

  Journal of Biological Chemistry, Jan. 2021

  
• Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

  Eva Marie Pfeil; Julian Brands; Nicole Merten; Timo Vögtle; Maddalena Vescovo; Ulrike Rick; Ina Maria Albrecht; Nina Heycke; Kouki Kawakami; Yuki Ono; Francois Marie Ngako Kadji; Suzune Hiratsuka; Junken Aoki; Felix Häberlein; Michaela Matthey; Jaspal Garg; Stephanie Hennen; Marie Lise Jobin; Kerstin Seier; Davide Calebiro; Alexander Pfeifer; Akos Heinemann; Daniela Wenzel; Gabriele M. König; Bernhard Nieswandt; Bernd K. Fleischmann; Asuka Inoue; Katharina Simon; Evi Kostenis

  Molecular Cell, 17 Dec. 2020

  
• Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

  Dohyun Im; Asuka Inoue; Takaaki Fujiwara; Takanori Nakane; Yasuaki Yamanaka; Tomoko Uemura; Chihiro Mori; Yuki Shiimura; Kanako Terakado Kimura; Hidetsugu Asada; Norimichi Nomura; Tomoyuki Tanaka; Ayumi Yamashita; Eriko Nango; Kensuke Tono; Francois Marie Ngako Kadji; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature Communications, Dec. 2020

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• 三量体G蛋白質-GEF-GAPシグナル:受容体シグナルの時空間的選択性と多様性の生化学 GPCRバイアスリガンドのシグナル機構の理解

  川上 耕季; 平塚 寿々音; 井上 飛鳥

  日本生化学会大会プログラム・講演要旨集, Sep. 2020

  
• Agonist-induced formation of unproductive receptor-G12 complexes

  Najeah Okashah; Shane C. Wright; Kouki Kawakami; Signe Mathiasen; Joris Zhou; Sumin Lu; Jonathan A. Javitch; Asuka Inoue; Michel Bouvier; Nevin A. Lambert

  Proceedings of the National Academy of Sciences of the United States of America, 01 Sep. 2020

  
• 新たな酸化脂質研究の潮流 酸化リン脂質とそのGPCR型受容体を介した痒みの知覚

  岸 貴之; 可野 邦行; 大村谷 昌樹; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2020

  
• G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.

  Signe Mathiasen; Tiago Palmisano; Nicole A Perry; Hannah M Stoveken; Alex Vizurraga; Dyke P McEwen; Najeah Okashah; Tobias Langenhan; Asuka Inoue; Nevin A Lambert; Gregory G Tall; Jonathan A Javitch

  Nature chemical biology, 10 Aug. 2020, Peer-reviewed

  
• Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs.

  Michael W Boesgaard; Kasper Harpsøe; Michelle Malmberg; Christina R Underwood; Asuka Inoue; Jesper M Mathiesen; Gabriele M König; Evi Kostenis; David E Gloriam; Hans Bräuner-Osborne

  The Journal of biological chemistry, 04 Aug. 2020, Peer-reviewed

  
• Structural insights into differences in G protein activation by family A and family B GPCRs.

  Daniel Hilger; Kaavya Krishna Kumar; Hongli Hu; Mie Fabricius Pedersen; Evan S O'Brien; Lise Giehm; Christine Jennings; Gözde Eskici; Asuka Inoue; Michael Lerch; Jesper Mosolff Mathiesen; Georgios Skiniotis; Brian K Kobilka

  Science (New York, N.Y.), 31 Jul. 2020, Peer-reviewed

  
• Non-naturally-occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity Towards G Protein-coupled Receptors.

  Sho Nakamura; Misa Sayama; Akiharu Uwamizu; Sejin Jung; Masaya Ikubo; Yuko Otani; Kuniyuki Kano; Jumpei Omi; Asuka Inoue; Junken Aoki; Tomohiko Ohwada

  Journal of medicinal chemistry, 28 Jul. 2020, Peer-reviewed

  
• Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation.

  Mithu Baidya; Punita Kumari; Hemlata Dwivedi-Agnihotri; Shubhi Pandey; Madhu Chaturvedi; Tomasz Maciej Stepniewski; Kouki Kawakami; Yubo Cao; Stéphane A Laporte; Jana Selent; Asuka Inoue; Arun K Shukla

  EMBO reports, 26 Jul. 2020, Peer-reviewed

  
• Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.

  Shoji Maeda; Jun Xu; Francois Marie N Kadji; Mary J Clark; Jiawei Zhao; Naotaka Tsutsumi; Junken Aoki; Roger K Sunahara; Asuka Inoue; K Christopher Garcia; Brian K Kobilka

  Science (New York, N.Y.), 10 Jul. 2020, Peer-reviewed

  
• G protein-regulated endocytic trafficking of adenylyl cyclase type 9.

  André M Lazar; Roshanak Irannejad; Tanya A Baldwin; Aparna B Sundaram; J Silvio Gutkind; Asuka Inoue; Carmen W Dessauer; Mark Von Zastrow

  eLife, 09 Jun. 2020, Peer-reviewed

  
• Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.

  Viktoriya Lukasheva; Dominic Devost; Christian Le Gouill; Yoon Namkung; Ryan D Martin; Jean-Michel Longpré; Mohammad Amraei; Yuji Shinjo; Mireille Hogue; Monique Lagacé; Billy Breton; Junken Aoki; Jason C Tanny; Stéphane A Laporte; Graciela Pineyro; Asuka Inoue; Michel Bouvier; Terence E Hébert

  Scientific reports, 29 May 2020, Peer-reviewed

  
• 免疫応答におけるリゾリン脂質シグナルの機能解明

  近江 純平; 新上 雄司; 可野 邦行; 上水 明治; 井上 飛鳥; 青木 淳賢

  脂質生化学研究, May 2020

  
• The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.

  Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Kunio Hirata; Yuki Shiimura; Dohyun Im; Tatsuro Shimamura; Norimichi Nomura; Hiroko Iwanari; Takao Hamakubo; Osamu Kusano-Arai; Hiromi Hisano; Tomoko Uemura; Chiyo Suno; Junken Aoki; So Iwata

  Structure (London, England : 1993), 07 Apr. 2020, Peer-reviewed

  
• Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

  Markus Kuschak; Vigneshwaran Namasivayam; Muhammad Rafehi; Jan H Voss; Jaspal Garg; Jonathan G Schlegel; Aliaa Abdelrahman; Stefan Kehraus; Raphael Reher; Jim Küppers; Katharina Sylvester; Sonja Hinz; Michaela Matthey; Daniela Wenzel; Bernd K Fleischmann; Alexander Pfeifer; Asuka Inoue; Michael Gütschow; Gabriele M König; Christa E Müller

  British journal of pharmacology, Apr. 2020, Peer-reviewed

  
• Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR.

  Alex D White; Frederic G Jean-Alphonse; Fei Fang; Karina A Peña; Shi Liu; Gabriele M König; Asuka Inoue; Despoina Aslanoglou; Samuel H Gellman; Evi Kostenis; Kunhong Xiao; Jean-Pierre Vilardaga

  Proceedings of the National Academy of Sciences of the United States of America, 31 Mar. 2020, Peer-reviewed

  
• Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.

  Misa Sayama; Akiharu Uwamizu; Yuko Otani; Asuka Inoue; Junken Aoki; Masakazu Sekijima; Tomohiko Ohwada

  Biochemistry, 24 Mar. 2020, Peer-reviewed

  
• クライオ電子顕微鏡を用いたメラトニン受容体シグナル伝達複合体の立体構造解析

  岡本 紘幸; 宮内 弘剛; 井上 飛鳥; 志甫谷 渉; 山下 恵太郎; 草木迫 司; 西澤 知宏; 濡木 理

  日本薬学会年会要旨集, Mar. 2020

  
• Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.

  Kazuhiro Kobayashi; Wataru Shihoya; Tomohiro Nishizawa; Francois Marie Ngako Kadji; Junken Aoki; Asuka Inoue; Osamu Nureki

  Nature structural & molecular biology, Mar. 2020, Peer-reviewed

  
• Structure of the neurotensin receptor 1 in complex with β-arrestin 1.

  Weijiao Huang; Matthieu Masureel; Qianhui Qu; John Janetzko; Asuka Inoue; Hideaki E Kato; Michael J Robertson; Khanh C Nguyen; Jeffrey S Glenn; Georgios Skiniotis; Brian K Kobilka

  Nature, Mar. 2020, Peer-reviewed

  
• Structural insight into small molecule action on Frizzleds.

  Paweł Kozielewicz; Ainoleena Turku; Carl-Fredrik Bowin; Julian Petersen; Jana Valnohova; Maria Consuelo Alonso Cañizal; Yuki Ono; Asuka Inoue; Carsten Hoffmann; Gunnar Schulte

  Nature communications, 21 Jan. 2020, Peer-reviewed

  
• Activation of the GLP-1 receptor by a non-peptidic agonist.

  Peishen Zhao; Yi-Lynn Liang; Matthew J Belousoff; Giuseppe Deganutti; Madeleine M Fletcher; Francis S Willard; Michael G Bell; Michael E Christe; Kyle W Sloop; Asuka Inoue; Tin T Truong; Lachlan Clydesdale; Sebastian G B Furness; Arthur Christopoulos; Ming-Wei Wang; Laurence J Miller; Christopher A Reynolds; Radostin Danev; Patrick M Sexton; Denise Wootten

  Nature, Jan. 2020, Peer-reviewed

  
• Spatial regulation of GPR64/ADGRG2 signaling by β-arrestins and GPCR kinases.

  Pedram Azimzadeh; Sarah C Talamantez-Lyburn; Katarina T Chang; Asuka Inoue; Nariman Balenga

  Annals of the New York Academy of Sciences, Nov. 2019, Peer-reviewed

  
• High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node.

  Szandor Simmons; Naoko Sasaki; Eiji Umemoto; Yutaka Uchida; Shigetomo Fukuhara; Yusuke Kitazawa; Michiyo Okudaira; Asuka Inoue; Kazuo Tohya; Keita Aoi; Junken Aoki; Naoki Mochizuki; Kenjiro Matsuno; Kiyoshi Takeda; Masayuki Miyasaka; Masaru Ishii

  eLife, 01 Oct. 2019, Peer-reviewed

  
• 新規酸化リン脂質受容体の呼吸制御機構の解析

  岸 貴之; 可野 邦行; 井上 飛鳥; 吉田 美沙紀; 大村谷 昌樹; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2019

  
• リゾホスファチジルセリンはオートクライン/パラクライン的に作用し活性化B細胞の凝集塊形成を抑制する

  上水 明治; 新上 雄司; 井上 飛鳥; 可野 邦行; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2019

  
• Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.

  Francesco Raimondi; Asuka Inoue; Francois M N Kadji; Ni Shuai; Juan-Carlos Gonzalez; Gurdeep Singh; Alicia Alonso de la Vega; Rocio Sotillo; Bernd Fischer; Junken Aoki; J Silvio Gutkind; Robert B Russell

  Oncogene, Sep. 2019, Peer-reviewed

  
• WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins.

  Carl-Fredrik Bowin; Asuka Inoue; Gunnar Schulte

  The Journal of biological chemistry, 02 Aug. 2019, Peer-reviewed

  
• Conformational transitions of a neurotensin receptor 1-Gi1 complex.

  Hideaki E Kato; Yan Zhang; Hongli Hu; Carl-Mikael Suomivuori; Francois Marie Ngako Kadji; Junken Aoki; Kaavya Krishna Kumar; Rasmus Fonseca; Daniel Hilger; Weijiao Huang; Naomi R Latorraca; Asuka Inoue; Ron O Dror; Brian K Kobilka; Georgios Skiniotis

  Nature, Aug. 2019, Peer-reviewed

  
• Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

  Teresa Buenaventura; Stavroula Bitsi; William E Laughlin; Thomas Burgoyne; Zekun Lyu; Affiong I Oqua; Hannah Norman; Emma R McGlone; Andrey S Klymchenko; Ivan R Corrêa Jr; Abigail Walker; Asuka Inoue; Aylin Hanyaloglu; Jak Grimes; Zsombor Koszegi; Davide Calebiro; Guy A Rutter; Stephen R Bloom; Ben Jones; Alejandra Tomas

  PLoS biology, Aug. 2019, Peer-reviewed

  
• Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy.

  Victoria Wu; Huwate Yeerna; Nijiro Nohata; Joshua Chiou; Olivier Harismendy; Francesco Raimondi; Asuka Inoue; Robert B Russell; Pablo Tamayo; J Silvio Gutkind

  The Journal of biological chemistry, 19 Jul. 2019, Peer-reviewed

  
• PRECOG: PREdicting COupling probabilities of G-protein coupled receptors.

  Gurdeep Singh; Asuka Inoue; J Silvio Gutkind; Robert B Russell; Francesco Raimondi

  Nucleic acids research, 02 Jul. 2019, Peer-reviewed

  
• An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases.

  Hiroki Kawana; Kuniyuki Kano; Hideo Shindou; Asuka Inoue; Takao Shimizu; Junken Aoki

  Biochimica et biophysica acta. Molecular and cell biology of lipids, Jul. 2019, Peer-reviewed

  
• Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes.

  Yu Hisano; Mari Kono; Andreane Cartier; Eric Engelbrecht; Kuniyuki Kano; Kouki Kawakami; Yanbao Xiong; Wenji Piao; Sylvain Galvani; Keisuke Yanagida; Andrew Kuo; Yuki Ono; Satoru Ishida; Junken Aoki; Richard L Proia; Jonathan S Bromberg; Asuka Inoue; Timothy Hla

  The Journal of experimental medicine, 01 Jul. 2019, Peer-reviewed

  
• Illuminating G-Protein-Coupling Selectivity of GPCRs.

  Asuka Inoue; Francesco Raimondi; Francois Marie Ngako Kadji; Gurdeep Singh; Takayuki Kishi; Akiharu Uwamizu; Yuki Ono; Yuji Shinjo; Satoru Ishida; Nadia Arang; Kouki Kawakami; J Silvio Gutkind; Junken Aoki; Robert B Russell

  Cell, 13 Jun. 2019, Peer-reviewed

  
• Variable G protein determinants of GPCR coupling selectivity.

  Najeah Okashah; Qingwen Wan; Soumadwip Ghosh; Manbir Sandhu; Asuka Inoue; Nagarajan Vaidehi; Nevin A Lambert

  Proceedings of the National Academy of Sciences of the United States of America, 11 Jun. 2019, Peer-reviewed

  
• Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity.

  Davide Malfacini; Julian Patt; Suvi Annala; Kasper Harpsøe; Funda Eryilmaz; Raphael Reher; Max Crüsemann; Wiebke Hanke; Hang Zhang; Daniel Tietze; David E Gloriam; Hans Bräuner-Osborne; Kristian Strømgaard; Gabriele M König; Asuka Inoue; Jesus Gomeza; Evi Kostenis

  The Journal of biological chemistry, 12 Apr. 2019, Peer-reviewed

  
• Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.

  Amanda E Mackenzie; Tezz Quon; Li-Chiung Lin; Alexander S Hauser; Laura Jenkins; Asuka Inoue; Andrew B Tobin; David E Gloriam; Brian D Hudson; Graeme Milligan

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Apr. 2019, Peer-reviewed

  
• Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.

  Suvi Annala; Xiaodong Feng; Naveen Shridhar; Funda Eryilmaz; Julian Patt; JuHee Yang; Eva M Pfeil; Rodolfo Daniel Cervantes-Villagrana; Asuka Inoue; Felix Häberlein; Tanja Slodczyk; Raphael Reher; Stefan Kehraus; Stefania Monteleone; Ramona Schrage; Nina Heycke; Ulrike Rick; Sandra Engel; Alexander Pfeifer; Peter Kolb; Gabriele König; Moritz Bünemann; Thomas Tüting; José Vázquez-Prado; J Silvio Gutkind; Evelyn Gaffal; Evi Kostenis

  Science signaling, 19 Mar. 2019, Peer-reviewed

  
• Non-Edg型LPA受容体LPA4-6及びGPR55の作動薬創製

  金藤 奨; 井上 飛鳥; 可野 邦行; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2019

  
• Gαiファミリー欠損細胞を用いたGPCR-Gαiサブタイプの共役の解析

  小野 雄基; 井上 飛鳥; 石田 覚; 川上 耕季; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2019

  
• Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism.

  Seigo Usuki; Noriko Tamura; Tomohiro Tamura; Shigeki Higashiyama; Kunikazu Tanji; Susumu Mitsutake; Asuka Inoue; Junken Aoki; Katsuyuki Mukai; Yasuyuki Igarashi

  Biochemistry and biophysics reports, Mar. 2019, Peer-reviewed

  
• Identification and biochemical characterization of a second zebrafish autotaxin gene.

  Ryoji Kise; Ryohei Okasato; Kuniyuki Kano; Asuka Inoue; Atsuo Kawahara; Junken Aoki

  Journal of biochemistry, 01 Mar. 2019, Peer-reviewed

  
• Efficacy of iguratimod vs. salazosulfapyridine as the first-line csDMARD for rheumatoid arthritis.

  Nozaki Y; Inoue A; Kinoshita K; Funauchi M; Matsumura I

  Modern rheumatology, Mar. 2019, Peer-reviewed

  
• Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells.

  Masahiro Kita; Yasuhisa Ano; Asuka Inoue; Junken Aoki

  Scientific reports, 28 Feb. 2019, Peer-reviewed

  
• Molecular mechanism of lysophosphatidic acid-induced hypertensive response.

  Kuniyuki Kano; Hirotaka Matsumoto; Asuka Inoue; Hiroshi Yukiura; Motomu Kanai; Jerold Chun; Satoshi Ishii; Takao Shimizu; Junken Aoki

  Scientific reports, 25 Feb. 2019, Peer-reviewed

  
• GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.

  Naoki Morita; Eiji Umemoto; Setsuko Fujita; Akio Hayashi; Junichi Kikuta; Ikuo Kimura; Takeshi Haneda; Toshio Imai; Asuka Inoue; Hitomi Mimuro; Yuichi Maeda; Hisako Kayama; Ryu Okumura; Junken Aoki; Nobuhiko Okada; Toshiyuki Kida; Masaru Ishii; Ryusuke Nabeshima; Kiyoshi Takeda

  Nature, Feb. 2019, Peer-reviewed

  
• Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine.

  Kanako Terakado Kimura; Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Dohyun Im; Chihiro Mori; Takatoshi Arakawa; Kunio Hirata; Yayoi Nomura; Norimichi Nomura; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature structural & molecular biology, Feb. 2019, Peer-reviewed

  
• Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis.

  Bradley L Hoare; Shoni Bruell; Ashish Sethi; Paul R Gooley; Michael J Lew; Mohammed A Hossain; Asuka Inoue; Daniel J Scott; Ross A D Bathgate

  iScience, 25 Jan. 2019, Peer-reviewed

  
• Asymmetric Recruitment of β-Arrestin1/2 by the Angiotensin II Type I and Prostaglandin F2α Receptor Dimer.

  Dany Fillion; Dominic Devost; Rory Sleno; Asuka Inoue; Terence E Hébert

  Frontiers in endocrinology, 2019, Peer-reviewed

  
• Combining Conformational Profiling of GPCRs with CRISPR/Cas9 Gene Editing Approaches.

  Kyla Bourque; Dominic Devost; Asuka Inoue; Terence E Hébert

  Methods in molecular biology (Clifton, N.J.), 2019, Peer-reviewed

  
• Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500.

  Chisae Nagiri; Wataru Shihoya; Asuka Inoue; Francois Marie Ngako Kadji; Junken Aoki; Osamu Nureki

  Communications biology, 2019, Peer-reviewed

  
• BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes.

  Shannon L O'Brien; Elizabeth K M Johnstone; Dominic Devost; Jacinta Conroy; Melissa E Reichelt; Brooke W Purdue; Mohammed A Ayoub; Tatsuo Kawai; Asuka Inoue; Satoru Eguchi; Terence E Hébert; Kevin D G Pfleger; Walter G Thomas

  Biochemical pharmacology, Dec. 2018, Peer-reviewed

  
• Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation.

  Wataru Shihoya; Tamaki Izume; Asuka Inoue; Keitaro Yamashita; Francois Marie Ngako Kadji; Kunio Hirata; Junken Aoki; Tomohiro Nishizawa; Osamu Nureki

  Nature communications, 09 Nov. 2018, Peer-reviewed

  
• The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids.

  Bryan Kuo; Erzsébet Szabó; Sue Chin Lee; Andrea Balogh; Derek Norman; Asuka Inoue; Yuki Ono; Junken Aoki; Gábor Tigyi

  Cellular signalling, Nov. 2018, Peer-reviewed

  
• Toward Structural Understanding of Ligand Recognition by Lysophosphatidic Acid Receptor Lpa6

  Taniguchi Reiya; Inoue Asuka; Sayama Misa; Yamashita Keitaro; Hirata Kunio; Yoshida Masahito; Nakada-Nakura Yoshiko; Otani Yuko; Kato Hideaki; Nishizawa Tomohiro; Doi Takayuki; Ohwada Tomohiko; Ishitani Ryuichiro; Aoki Junken; Nureki Osamu

  PROTEIN SCIENCE, Nov. 2018, Peer-reviewed

  
• Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2.

  Yoshimi Matsuo; Yuhki Yanase; Reiko Irifuku; Shunsuke Takahagi; Shoji Mihara; Kaori Ishii; Tomoko Kawaguchi; Akio Tanaka; Kazumasa Iwamoto; Haruka Watanuki; Kazuyuki Furuta; Satoshi Tanaka; Asuka Inoue; Junken Aoki; Michihiro Hide

  Allergy, Nov. 2018, Peer-reviewed

  
• Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor.

  Adam L Valkovic; Miranda B Leckey; Alice R Whitehead; Mohammed A Hossain; Asuka Inoue; Martina Kocan; Ross A D Bathgate

  Pharmacology research & perspectives, Oct. 2018, Peer-reviewed

  
• Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4.

  Yoshimitsu Nakanishi; Modong Tan; Takako Ichiki; Asuka Inoue; Jun-Ichi Yoshihara; Naoto Maekawa; Itsuki Takenoshita; Keisuke Yanagida; Shinya Yamahira; Satoshi Yamaguchi; Junken Aoki; Teruyuki Nagamune; Takehiko Yokomizo; Takao Shimizu; Motonao Nakamura

  Science signaling, 21 Aug. 2018, Peer-reviewed

  
• The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.

  Takahiro Nagatake; Yumiko Shiogama; Asuka Inoue; Junichi Kikuta; Tetsuya Honda; Prabha Tiwari; Takayuki Kishi; Atsushi Yanagisawa; Yosuke Isobe; Naomi Matsumoto; Michiko Shimojou; Sakiko Morimoto; Hidehiko Suzuki; So-Ichiro Hirata; Pär Steneberg; Helena Edlund; Junken Aoki; Makoto Arita; Hiroshi Kiyono; Yasuhiro Yasutomi; Masaru Ishii; Kenji Kabashima; Jun Kunisawa

  The Journal of allergy and clinical immunology, Aug. 2018, Peer-reviewed

  
• Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice

  Hideyuki Yanai; Shiho Chiba; Sho Hangai; Kohei Kometani; Asuka Inoue; Yoshitaka Kimura; Takaya Abe; Hiroshi Kiyonari; Junko Nishio; Naoko Taguchi-Atarashi; Yu Mizushima; Hideo Negishi; Rudolf Grosschedl; Tadatsugu Taniguchi

  Proceedings of the National Academy of Sciences of the United States of America, 15 May 2018, Peer-reviewed

  
• Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells.

  Qingwen Wan; Najeah Okashah; Asuka Inoue; Rony Nehmé; Byron Carpenter; Christopher G Tate; Nevin A Lambert

  The Journal of biological chemistry, 11 May 2018, Peer-reviewed

  
• On the G protein-coupling selectivity of the native A2B adenosine receptor.

  Zhan-Guo Gao; Asuka Inoue; Kenneth A Jacobson

  Biochemical pharmacology, May 2018, Peer-reviewed

  
• Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways.

  Graeme Milligan; Asuka Inoue

  Trends in pharmacological sciences, May 2018, Peer-reviewed

  
• Targeting GLP-1 receptor trafficking to improve agonist efficacy.

  Ben Jones; Teresa Buenaventura; Nisha Kanda; Pauline Chabosseau; Bryn M Owen; Rebecca Scott; Robert Goldin; Napat Angkathunyakul; Ivan R Corrêa Jr; Domenico Bosco; Paul R Johnson; Lorenzo Piemonti; Piero Marchetti; A M James Shapiro; Blake J Cochran; Aylin C Hanyaloglu; Asuka Inoue; Tricia Tan; Guy A Rutter; Alejandra Tomas; Stephen R Bloom

  Nature communications, 23 Apr. 2018, Peer-reviewed

  
• Receptor- and cellular compartment-specific activation of the cAMP/PKA pathway by α1-adrenergic and ETA endothelin receptors.

  Ryan D Martin; Yalin Sun; Kyla Bourque; Nicolas Audet; Asuka Inoue; Jason C Tanny; Terence E Hébert

  Cellular signalling, Apr. 2018, Peer-reviewed

  
• Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors.

  Maria Buur Nordskov Gabe; Alexander Hovard Sparre-Ulrich; Mie Fabricius Pedersen; Lærke Smidt Gasbjerg; Asuka Inoue; Hans Bräuner-Osborne; Bolette Hartmann; Mette Marie Rosenkilde

  Biochemical pharmacology, Apr. 2018, Peer-reviewed

  
• CRISPR/Cas9-mediated Knockout of G Proteins and beta-arrestins Determines Transducer Specific Contributions to Dopamine D1 Receptor Signaling

  Jain Manish K; Nilson Ashley N; Felsing Daniel E; Inoue Asuka; Allen John A

  FASEB JOURNAL, Apr. 2018, Peer-reviewed

  
• The Role of Distal Helix 5 as a Determinant of GPCR-G protein Coupling Selectivity

  Okashah Najeah; Wan Qingwen; Inoue Asuka; Lambert Nevin

  FASEB JOURNAL, Apr. 2018, Peer-reviewed

  
• G protein-dependent signaling triggers a β-arrestin-scaffolded p70S6K/ rpS6 module that controls 5'TOP mRNA translation.

  Aurélie Tréfier; Astrid Musnier; Flavie Landomiel; Thomas Bourquard; Thomas Boulo; Mohammed Akli Ayoub; Kelly León; Gilles Bruneau; Manon Chevalier; Guillaume Durand; Marie-Claire Blache; Asuka Inoue; Joël Fontaine; Christophe Gauthier; Sophie Tesseraud; Eric Reiter; Anne Poupon; Pascale Crépieux

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Mar. 2018, Peer-reviewed

  
• Lack of beta-arrestin signaling in the absence of active G proteins.

  Manuel Grundmann; Nicole Merten; Davide Malfacini; Asuka Inoue; Philip Preis; Katharina Simon; Nelly Rüttiger; Nicole Ziegler; Tobias Benkel; Nina Katharina Schmitt; Satoru Ishida; Ines Müller; Raphael Reher; Kouki Kawakami; Ayumi Inoue; Ulrike Rick; Toni Kühl; Diana Imhof; Junken Aoki; Gabriele M König; Carsten Hoffmann; Jesus Gomeza; Jürgen Wess; Evi Kostenis

  Nature communications, 23 Jan. 2018, Peer-reviewed

  
• AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.

  Caroline M Gorvin; Angela Rogers; Benoit Hastoy; Andrei I Tarasov; Morten Frost; Silvia Sposini; Asuka Inoue; Michael P Whyte; Patrik Rorsman; Aylin C Hanyaloglu; Gerda E Breitwieser; Rajesh V Thakker

  Cell reports, 23 Jan. 2018, Peer-reviewed

  
• Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174.

  Yuji Shinjo; Kumiko Makide; Keita Satoh; Fumiya Fukami; Asuka Inoue; Kuniyuki Kano; Yuko Otani; Tomohiko Ohwada; Junken Aoki

  Biochemical and biophysical research communications, 09 Dec. 2017, Peer-reviewed

  
• The Calcium-Sensing Receptor, a Class C GPCR, Spatially-Directs G-protein Selectivity via Endosomal Signaling.

  Caroline Gorvin; Angela Rogers; Benoit Hastoy; Andrei Tarasov; Morten Frost; Asuka Inoue; Michael Whyte; Patrik Rorsman; Aylin Hanyaloglu; Gerda Breitwieser; Rajesh Thakker

  JOURNAL OF BONE AND MINERAL RESEARCH, Dec. 2017, Peer-reviewed

  
• A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.

  Eugenia Sergeev; Anders Højgaard Hansen; Daniele Bolognini; Kouki Kawakami; Takayuki Kishi; Junken Aoki; Trond Ulven; Asuka Inoue; Brian D Hudson; Graeme Milligan

  Scientific reports, 23 Oct. 2017, Peer-reviewed

  
• Genetic variants affecting equivalent protein family positions reflect human diversity.

  Francesco Raimondi; Matthew J Betts; Qianhao Lu; Asuka Inoue; J Silvio Gutkind; Robert B Russell

  Scientific reports, 06 Oct. 2017, Peer-reviewed

  
• X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog.

  Wataru Shihoya; Tomohiro Nishizawa; Keitaro Yamashita; Asuka Inoue; Kunio Hirata; Francois Marie Ngako Kadji; Akiko Okuta; Kazutoshi Tani; Junken Aoki; Yoshinori Fujiyoshi; Tomoko Doi; Osamu Nureki

  Nature structural & molecular biology, Sep. 2017, Peer-reviewed

  
• Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.

  Reiya Taniguchi; Asuka Inoue; Misa Sayama; Akiharu Uwamizu; Keitaro Yamashita; Kunio Hirata; Masahito Yoshida; Yoshiki Tanaka; Hideaki E Kato; Yoshiko Nakada-Nakura; Yuko Otani; Tomohiro Nishizawa; Takayuki Doi; Tomohiko Ohwada; Ryuichiro Ishitani; Junken Aoki; Osamu Nureki

  Nature, 17 Aug. 2017, Peer-reviewed

  
• Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.

  Susanne Prokop; Nicole A Perry; Sergey A Vishnivetskiy; Andras D Toth; Asuka Inoue; Graeme Milligan; Tina M Iverson; Laszlo Hunyady; Vsevolod V Gurevich

  Cellular signalling, Aug. 2017, Peer-reviewed

  
• C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways.

  Jeffrey S Smith; Priya Alagesan; Nimit K Desai; Thomas F Pack; Jiao-Hui Wu; Asuka Inoue; Neil J Freedman; Sudarshan Rajagopal

  Molecular pharmacology, Aug. 2017, Peer-reviewed

  
• Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis.

  Misa Sayama; Asuka Inoue; Sho Nakamura; Sejin Jung; Masaya Ikubo; Yuko Otani; Akiharu Uwamizu; Takayuki Kishi; Kumiko Makide; Junken Aoki; Takatsugu Hirokawa; Tomohiko Ohwada

  Journal of medicinal chemistry, 27 Jul. 2017, Peer-reviewed

  
• Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.

  Rory Sleno; Dominic Devost; Darlaine Pétrin; Alice Zhang; Kyla Bourque; Yuji Shinjo; Junken Aoki; Asuka Inoue; Terence E Hébert

  The Journal of biological chemistry, 21 Jul. 2017, Peer-reviewed

  
• Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.

  Shizu Aikawa; Kuniyuki Kano; Asuka Inoue; Jiao Wang; Daisuke Saigusa; Takeshi Nagamatsu; Yasushi Hirota; Tomoyuki Fujii; Soken Tsuchiya; Yoshitaka Taketomi; Yukihiko Sugimoto; Makoto Murakami; Makoto Arita; Makoto Kurano; Hitoshi Ikeda; Yutaka Yatomi; Jerold Chun; Junken Aoki

  The EMBO journal, 14 Jul. 2017, Peer-reviewed

  
• Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

  Morgan O'Hayre; Kelsie Eichel; Silvia Avino; Xuefeng Zhao; Dana J Steffen; Xiaodong Feng; Kouki Kawakami; Junken Aoki; Karen Messer; Roger Sunahara; Asuka Inoue; Mark von Zastrow; J Silvio Gutkind

  Science signaling, 20 Jun. 2017, Peer-reviewed

  
• Identification and pharmacological characterization of succinate receptor agonists.

  Pierre Geubelle; Julie Gilissen; Sébastien Dilly; Laurence Poma; Nadine Dupuis; Céline Laschet; Dayana Abboud; Asuka Inoue; François Jouret; Bernard Pirotte; Julien Hanson

  British journal of pharmacology, May 2017, Peer-reviewed

  
• Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells.

  Wayne Stallaert; Emma T van der Westhuizen; Anne-Marie Schönegge; Bianca Plouffe; Mireille Hogue; Viktoria Lukashova; Asuka Inoue; Satoru Ishida; Junken Aoki; Christian Le Gouill; Michel Bouvier

  Molecular pharmacology, May 2017, Peer-reviewed

  
• Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context.

  Dominic Devost; Rory Sleno; Darlaine Pétrin; Alice Zhang; Yuji Shinjo; Rakan Okde; Junken Aoki; Asuka Inoue; Terence E Hébert

  The Journal of biological chemistry, 31 Mar. 2017, Peer-reviewed

  
• Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

  Thomas J Cahill 3rd; Alex R B Thomsen; Jeffrey T Tarrasch; Bianca Plouffe; Anthony H Nguyen; Fan Yang; Li-Yin Huang; Alem W Kahsai; Daniel L Bassoni; Bryant J Gavino; Jane E Lamerdin; Sarah Triest; Arun K Shukla; Benjamin Berger; John Little 4th; Albert Antar; Adi Blanc; Chang-Xiu Qu; Xin Chen; Kouki Kawakami; Asuka Inoue; Junken Aoki; Jan Steyaert; Jin-Peng Sun; Michel Bouvier; Georgios Skiniotis; Robert J Lefkowitz

  Proceedings of the National Academy of Sciences of the United States of America, 07 Mar. 2017, Peer-reviewed

  
• Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling.

  Shizu Aikawa; Kuniyuki Kano; Asuka Inoue; Junken Aoki

  Biochemical and biophysical research communications, 26 Feb. 2017, Peer-reviewed

  
• Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.

  Kelly L Roszko; Ruiye Bi; Caroline M Gorvin; Hans Bräuner-Osborne; Xiao-Feng Xiong; Asuka Inoue; Rajesh V Thakker; Kristian Strømgaard; Thomas Gardella; Michael Mannstadt

  JCI insight, 09 Feb. 2017, Peer-reviewed

  
• Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.

  Stine Jørgensen; Christian Theil Have; Christina Rye Underwood; Lars Dan Johansen; Petrine Wellendorph; Anette Prior Gjesing; Christinna V Jørgensen; Shi Quan; Gao Rui; Asuka Inoue; Allan Linneberg; Niels Grarup; Wang Jun; Oluf Pedersen; Torben Hansen; Hans Bräuner-Osborne

  The Journal of biological chemistry, 27 Jan. 2017, Peer-reviewed

  
• 1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells.

  Yohei Manabe; Marie Yoshimura; Kazuma Sakamaki; Asuka Inoue; Aya Kakinoki; Satoshi Hokari; Mariko Sakanaka; Junken Aoki; Hiroyuki Miyachi; Kazuyuki Furuta; Satoshi Tanaka

  European journal of immunology, Jan. 2017, Peer-reviewed

  
• Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

  Colleen L Doçi; Constantinos M Mikelis; Juan Luis Callejas-Valera; Karina K Hansen; Alfredo A Molinolo; Asuka Inoue; Stefan Offermanns; J Silvio Gutkind

  PloS one, 2017, Peer-reviewed

  
• Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.

  Elisa Alvarez-Curto; Asuka Inoue; Laura Jenkins; Sheikh Zahir Raihan; Rudi Prihandoko; Andrew B Tobin; Graeme Milligan

  The Journal of biological chemistry, 30 Dec. 2016, Peer-reviewed

  
• Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation.

  Takayuki Kishi; Hiroki Kawana; Misa Sayama; Kumiko Makide; Asuka Inoue; Yuko Otani; Tomohiko Ohwada; Junken Aoki

  Biochemistry and biophysics reports, Dec. 2016, Peer-reviewed

  
• Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

  Sebastian George Barton Furness; Yi-Lynn Liang; Cameron James Nowell; Michelle Louise Halls; Peter John Wookey; Emma Dal Maso; Asuka Inoue; Arthur Christopoulos; Denise Wootten; Patrick Michael Sexton

  Cell, 20 Oct. 2016, Peer-reviewed

  
• Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction

  Y. Nagura; N. H. Tsuno; K. Kano; A. Inoue; J. Aoki; Y. Hirowatari; M. Kaneko; M. Kurano; M. Matsuhashi; R. Ohkawa; M. Tozuka; Y. Yatomi; H. Okazaki

  Transfusion Medicine, 01 Oct. 2016, Peer-reviewed

  
• Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: A tumor suppressor function for the Gα13/RhoA axis in B cells

  M. O'Hayre; A. Inoue; I. Kufareva; Z. Wang; C. M. Mikelis; R. A. Drummond; S. Avino; K. Finkel; K. W. Kalim; G. Dipasquale; F. Guo; J. Aoki; Y. Zheng; M. S. Lionakis; A. A. Molinolo; J. S. Gutkind

  Oncogene, 21 Jul. 2016, Peer-reviewed

  
• Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.

  Sejin Jung; Asuka Inoue; Sho Nakamura; Takayuki Kishi; Akiharu Uwamizu; Misa Sayama; Masaya Ikubo; Yuko Otani; Kuniyuki Kano; Kumiko Makide; Junken Aoki; Tomohiko Ohwada

  Journal of medicinal chemistry, 28 Apr. 2016, Peer-reviewed

  
• A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

  Jianxin Hu; Matthew Stern; Luis E Gimenez; Lizzy Wanka; Lu Zhu; Mario Rossi; Jaroslawna Meister; Asuka Inoue; Annette G Beck-Sickinger; Vsevolod V Gurevich; Jürgen Wess

  The Journal of biological chemistry, 08 Apr. 2016, Peer-reviewed

  
• ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.

  Tatsuji Nishioka; Naoaki Arima; Kuniyuki Kano; Kotaro Hama; Eriko Itai; Hiroshi Yukiura; Ryoji Kise; Asuka Inoue; Seok-Hyung Kim; Lilianna Solnica-Krezel; Wouter H Moolenaar; Jerold Chun; Junken Aoki

  Scientific reports, 23 Mar. 2016, Peer-reviewed

  
• Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.

  Akira Takeda; Daichi Kobayashi; Keita Aoi; Naoko Sasaki; Yuki Sugiura; Hidemitsu Igarashi; Kazuo Tohya; Asuka Inoue; Erina Hata; Noriyuki Akahoshi; Haruko Hayasaka; Junichi Kikuta; Elke Scandella; Burkhard Ludewig; Satoshi Ishii; Junken Aoki; Makoto Suematsu; Masaru Ishii; Kiyoshi Takeda; Sirpa Jalkanen; Masayuki Miyasaka; Eiji Umemoto

  eLife, 02 Feb. 2016, Peer-reviewed

  
• The experimental power of FR900359 to study Gq-regulated biological processes.

  Ramona Schrage; Anna-Lena Schmitz; Evelyn Gaffal; Suvi Annala; Stefan Kehraus; Daniela Wenzel; Katrin M Büllesbach; Tobias Bald; Asuka Inoue; Yuji Shinjo; Ségolène Galandrin; Naveen Shridhar; Michael Hesse; Manuel Grundmann; Nicole Merten; Thomas H Charpentier; Matthew Martz; Adrian J Butcher; Tanja Slodczyk; Sylvain Armando; Maike Effern; Yoon Namkung; Laura Jenkins; Velten Horn; Anne Stößel; Harald Dargatz; Daniel Tietze; Diana Imhof; Céline Galés; Christel Drewke; Christa E Müller; Michael Hölzel; Graeme Milligan; Andrew B Tobin; Jesús Gomeza; Henrik G Dohlman; John Sondek; T Kendall Harden; Michel Bouvier; Stéphane A Laporte; Junken Aoki; Bernd K Fleischmann; Klaus Mohr; Gabriele M König; Thomas Tüting; Evi Kostenis

  Nature communications, 14 Dec. 2015, Peer-reviewed

  
• Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids.

  Makoto Kurano; Tomotaka Dohi; Takahiro Nojiri; Tamaki Kobayashi; Yuji Hirowatari; Asuka Inoue; Kuniyuki Kano; Hirotaka Matsumoto; Koji Igarashi; Masako Nishikawa; Katsumi Miyauchi; Hiroyuki Daida; Hitoshi Ikeda; Junken Aoki; Yutaka Yatomi

  BBA clinical, Dec. 2015, Peer-reviewed

  
• LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells.

  Hiroshi Yukiura; Kuniyuki Kano; Ryoji Kise; Asuka Inoue; Junken Aoki

  Journal of cell science, 01 Nov. 2015, Peer-reviewed

  
• NEURONAL DEVELOPMENT. Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord.

  Adam T Guy; Yasuko Nagatsuka; Noriko Ooashi; Mariko Inoue; Asuka Nakata; Peter Greimel; Asuka Inoue; Takuji Nabetani; Akiho Murayama; Kunihiro Ohta; Yukishige Ito; Junken Aoki; Yoshio Hirabayashi; Hiroyuki Kamiguchi

  Science (New York, N.Y.), 28 Aug. 2015, Peer-reviewed

  
• Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis.

  Yu Hisano; Asuka Inoue; Kiyohito Taimatsu; Satoshi Ota; Rie Ohga; Hirohito Kotani; Michiko Muraki; Junken Aoki; Atsuo Kawahara

  Genes to cells : devoted to molecular & cellular mechanisms, Aug. 2015, Peer-reviewed

  
• Novel roles for GNA13 and RHOA as tumor suppressor genes

  Morgan O'hayre; Asuka Inoue; Katiuchia Sales; Irina Kufareva; Juan Luis Callejas Valera; Fukun Guo; Constantinos Mikelis; Giovanni DiPasquale; Kira Finkel; Junken Aoki; Yi Zheng; Thomas H. Bugge; J. Silvio Gutkind

  CANCER RESEARCH, Aug. 2015, Peer-reviewed

  
• Quantitative evaluation of G protein coupling with GPCRs

  Inoue Asuka; Aoki Junken

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Peer-reviewed

  
• Maternal and Zygotic Sphingosine Kinase 2 Are Indispensable for Cardiac Development in Zebrafish.

  Yu Hisano; Asuka Inoue; Michiyo Okudaira; Kiyohito Taimatsu; Hirotaka Matsumoto; Hirohito Kotani; Rie Ohga; Junken Aoki; Atsuo Kawahara

  The Journal of biological chemistry, 12 Jun. 2015, Peer-reviewed

  
• Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6.

  Ryota Hayashi; Asuka Inoue; Yasushi Suga; Junken Aoki; Yutaka Shimomura

  Journal of dermatological science, Jun. 2015, Peer-reviewed

  
• Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174.

  Masaya Ikubo; Asuka Inoue; Sho Nakamura; Sejin Jung; Misa Sayama; Yuko Otani; Akiharu Uwamizu; Keisuke Suzuki; Takayuki Kishi; Akira Shuto; Jun Ishiguro; Michiyo Okudaira; Kuniyuki Kano; Kumiko Makide; Junken Aoki; Tomohiko Ohwada

  Journal of medicinal chemistry, 28 May 2015, Peer-reviewed

  
• Lysophosphatidylserine analogues differentially activate three LysoPS receptors.

  Akiharu Uwamizu; Asuka Inoue; Kensuke Suzuki; Michiyo Okudaira; Akira Shuto; Yuji Shinjo; Jun Ishiguro; Kumiko Makide; Masaya Ikubo; Sho Nakamura; Sejin Jung; Misa Sayama; Yuko Otani; Tomohiko Ohwada; Junken Aoki

  Journal of biochemistry, Mar. 2015, Peer-reviewed

  
• Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.

  Yuuki Iida; Eiji Sunami; Hiroharu Yamashita; Masaya Hiyoshi; Soichiro Ishihara; Hironori Yamaguchi; Asuka Inoue; Kumiko Makide; Nelson H Tsuno; Junken Aoki; Joji Kitayama; Toshiaki Watanabe

  Anticancer research, Mar. 2015, Peer-reviewed

  
• Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.

  Makoto Kurano; Akiko Suzuki; Asuka Inoue; Yasunori Tokuhara; Kuniyuki Kano; Hirotaka Matsumoto; Koji Igarashi; Ryunosuke Ohkawa; Kazuhiro Nakamura; Tomotaka Dohi; Katsumi Miyauchi; Hiroyuki Daida; Kazuhisa Tsukamoto; Hitoshi Ikeda; Junken Aoki; Yutaka Yatomi

  Arteriosclerosis, thrombosis, and vascular biology, Feb. 2015, Peer-reviewed

  
• Detection of Physiological Activities of G Protein-Coupled Receptor-Acting Pharmaceuticals in Wastewater

  Masaru Ihara; Asuka Inoue; Seiya Hanamoto; Han Zhang; Junken Aoki; Hiroaki Tanaka

  ENVIRONMENTAL SCIENCE & TECHNOLOGY, Feb. 2015, Peer-reviewed

  
• Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic Acid in acute coronary syndrome.

  Makoto Kurano; Akiko Suzuki; Asuka Inoue; Yasunori Tokuhara; Kuniyuki Kano; Hirotaka Matsumoto; Koji Igarashi; Ryunosuke Ohkawa; Kazuhiro Nakamura; Tomotaka Dohi; Katsumi Miyauchi; Hiroyuki Daida; Kazuhisa Tsukamoto; Hitoshi Ikeda; Junken Aoki; Yutaka Yatomi

  Arterioscler. Thromb. Vasc. Biol., Feb. 2015, Peer-reviewed

  
• Autotaxin overexpression causes embryonic lethality and vascular defects.

  Hiroshi Yukiura; Kuniyuki Kano; Ryoji Kise; Asuka Inoue; Junken Aoki

  PloS one, 2015, Peer-reviewed

  
• Measuring Activation of Lipid G Protein- Coupled Receptors Using the TGF-á Shedding Assay

  Asuka Inoue; Junken Aoki

  Bioactive Lipid Mediators: Current Reviews and Protocols, 01 Jan. 2015, Peer-reviewed

  
• Novel lysophosphoplipid receptors: their structure and function.

  Kumiko Makide; Akiharu Uwamizu; Yuji Shinjo; Jun Ishiguro; Michiyo Okutani; Asuka Inoue; Junken Aoki

  Journal of lipid research, Oct. 2014, Peer-reviewed

  
• Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS.

  Michiyo Okudaira; Asuka Inoue; Akira Shuto; Keita Nakanaga; Kuniyuki Kano; Kumiko Makide; Daisuke Saigusa; Yoshihisa Tomioka; Junken Aoki

  Journal of lipid research, Oct. 2014, Peer-reviewed

  
• Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.

  Jun Kunisawa; Eri Hashimoto; Asuka Inoue; Risa Nagasawa; Yuji Suzuki; Izumi Ishikawa; Shiori Shikata; Makoto Arita; Junken Aoki; Hiroshi Kiyono

  Journal of immunology (Baltimore, Md. : 1950), 15 Aug. 2014, Peer-reviewed

  
• Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.

  Keita Nakanaga; Kotaro Hama; Kuniyuki Kano; Takanao Sato; Hiroshi Yukiura; Asuka Inoue; Daisuke Saigusa; Hidetoshi Tokuyama; Yoshihisa Tomioka; Hiroshi Nishina; Atsuo Kawahara; Junken Aoki

  Journal of biochemistry, Apr. 2014, Peer-reviewed

  
• [TGFalpha shedding assay is useful for identifying ligands for orphan GPCRs].

  Asuka Inoue; Junken Aoki

  Seikagaku. The Journal of Japanese Biochemical Society, Nov. 2013, Peer-reviewed

  
• A novel mutation, c.699C > G (p.C233W), in the LIPH gene leads to a loss of the hydrolytic activity and the LPA(6) activation ability of PA-PLA(1)alpha in autosomal recessive wooly hair/hypotrichosis

  Mayuko Yoshizawa; Motonobu Nakamura; Muhammad Farooq; Asuka Inoue; Junken Aoki; Yutaka Shimomura

  JOURNAL OF DERMATOLOGICAL SCIENCE, Oct. 2013, Peer-reviewed

  
• A novel heterozygous deletion-insertion mutation in the mouse Krt71 gene underlies wavy coat phenotype

  A. Fujimoto; A. Inoue; M. Farooq; H. Fujikawa; J. Aoki; M. Ito; Y. Shimomura

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2013, Peer-reviewed

  
• Mitochondria-type GPAT is required for mitochondrial fusion

  Yohsuke Ohba; Takeshi Sakuragi; Eriko Kage-Nakadai; Naoko H. Tomioka; Nozomu Kono; Rieko Imae; Asuka Inoue; Junken Aoki; Naotada Ishihara; Takao Inoue; Shohei Mitani; Hiroyuki Arai

  EMBO JOURNAL, May 2013, Peer-reviewed

  
• Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): Metabolically stabilized LPA receptor agonists

  Guowei Jiang; Asuka Inoue; Junken Aoki; Glenn D. Prestwich

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 2013, Peer-reviewed

  
• Pharmacological characterization of zebrafish Ca2+-mobilizing prostanoid receptors

  Ryo Iwasaki; Atsuo Kawahara; Asuka Inoue; Junken Aoki; Soken Tsuchiya; Yukihiko Sugimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Peer-reviewed

  
• TGFα shedding assay: an accurate and versatile method for detecting GPCR activation.

  Asuka Inoue; Jun Ishiguro; Hajime Kitamura; Naoaki Arima; Michiyo Okutani; Akira Shuto; Shigeki Higashiyama; Tomohiko Ohwada; Hiroyuki Arai; Kumiko Makide; Junken Aoki

  Nature methods, Oct. 2012, Peer-reviewed

  
• A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis.

  Atsushi Fujimoto; Muhammad Farooq; Hiroki Fujikawa; Asuka Inoue; Manabu Ohyama; Ritsuko Ehama; Jotaro Nakanishi; Motofumi Hagihara; Tokuro Iwabuchi; Junken Aoki; Masaaki Ito; Yutaka Shimomura

  The Journal of investigative dermatology, Oct. 2012, Peer-reviewed

  
• The beta 9 Loop Domain of PA-PLA(1)alpha Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis

  Satoru Shinkuma; Asuka Inoue; Junken Aoki; Wataru Nishie; Ken Natsuga; Hideyuki Ujiie; Toshifumi Nomura; Riichiro Abe; Masashi Akiyama; Hiroshi Shimizu

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Aug. 2012, Peer-reviewed

  
• Synthesis and biological evaluation of optically active Ki16425.

  Takanao Sato; Kenji Sugimoto; Asuka Inoue; Shinichi Okudaira; Junken Aoki; Hidetoshi Tokuyama

  Bioorganic & medicinal chemistry letters, 01 Jul. 2012, Peer-reviewed

  
• Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.

  Daisuke Saigusa; Kanako Shiba; Asuka Inoue; Kotaro Hama; Michiyo Okutani; Nagisa Iida; Masayoshi Saito; Kaori Suzuki; Tohru Kaneko; Naoto Suzuki; Hiroaki Yamaguchi; Nariyasu Mano; Junichi Goto; Takanori Hishinuma; Junken Aoki; Yoshihisa Tomioka

  Analytical and bioanalytical chemistry, Jun. 2012, Peer-reviewed

  
• GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.

  Hajime Kitamura; Kumiko Makide; Akira Shuto; Masaya Ikubo; Asuka Inoue; Kensuke Suzuki; Yusuke Sato; Sho Nakamura; Yuko Otani; Tomohiko Ohwada; Junken Aoki

  Journal of biochemistry, May 2012, Peer-reviewed

  
• A missense mutation within the helix initiation motif of the keratin 71 (KRT71) gene underlies autosomal dominant woolly hair/hypotrichosis

  A. Fujimoto; A. Inoue; M. Ohyama; H. Fujikawa; M. Farooq; R. Ehama; J. Nakanishi; M. Hagihara; T. Iwabuchi; J. Aoki; M. Ito; Y. Shimomura

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2012, Peer-reviewed

  
• The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

  Shigetomo Fukuhara; Szandor Simmons; Shunsuke Kawamura; Asuka Inoue; Yasuko Orba; Takeshi Tokudome; Yuji Sunden; Yuji Arai; Kazumasa Moriwaki; Junji Ishida; Akiyoshi Uemura; Hiroshi Kiyonari; Takaya Abe; Akiyoshi Fukamizu; Masanori Hirashima; Hirofumi Sawa; Junken Aoki; Masaru Ishii; Naoki Mochizuki

  JOURNAL OF CLINICAL INVESTIGATION, Apr. 2012, Peer-reviewed

  
• Surface loops of extracellular phospholipase A(1) determine both substrate specificity and preference for lysophospholipids.

  Naoaki Arima; Asuka Inoue; Kumiko Makide; Takamasa Nonaka; Junken Aoki

  Journal of lipid research, Mar. 2012, Peer-reviewed

  
• Regulation of Peroxisomal Lipid Metabolism by Catalytic Activity of Tumor Suppressor H-rev107

  Toru Uyama; Ikuyo Ichi; Nozomu Kono; Asuka Inoue; Kazuhito Tsuboi; Xing-Hua Jin; Nobukazu Araki; Junken Aoki; Hiroyuki Arai; Natsuo Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2012, Peer-reviewed

  
• Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.

  Hiroshi Yukiura; Kotaro Hama; Keita Nakanaga; Masayuki Tanaka; Yoichi Asaoka; Shinichi Okudaira; Naoaki Arima; Asuka Inoue; Takafumi Hashimoto; Hiroyuki Arai; Atsuo Kawahara; Hiroshi Nishina; Junken Aoki

  The Journal of biological chemistry, 23 Dec. 2011, Peer-reviewed

  
• LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling.

  Asuka Inoue; Naoaki Arima; Jun Ishiguro; Glenn D Prestwich; Hiroyuki Arai; Junken Aoki

  The EMBO journal, 19 Aug. 2011, Peer-reviewed

  
• [Physiological functions of lysophosphatidylserine].

  Asuka Inoue; Michiyo Okutani; Junken Aoki

  Seikagaku. The Journal of Japanese Biochemical Society, Jun. 2011, Peer-reviewed

  
• Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.

  Hiroshi Nishimasu; Shinichi Okudaira; Kotaro Hama; Emiko Mihara; Naoshi Dohmae; Asuka Inoue; Ryuichiro Ishitani; Junichi Takagi; Junken Aoki; Osamu Nureki

  Nature structural & molecular biology, Feb. 2011, Peer-reviewed

  
• Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

  Hiroshi Nishimasu; Shinichi Okudaira; Kotaro Hama; Emiko Mihara; Naoshi Dohmae; Asuka Inoue; Ryuichiro Ishitani; Junichi Takagi; Junken Aoki; Osamu Nureki

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Feb. 2011, Peer-reviewed

  
• Prevalent LIPH Founder Mutations Lead to Loss of P2Y5 Activation Ability of PA-PLA(1)alpha in Autosomal Recessive Hypotrichosis

  Satoru Shinkuma; Masashi Akiyama; Asuka Inoue; Junken Aoki; Ken Natsuga; Toshifumi Nomura; Ken Arita; Riichiro Abe; Kei Ito; Hideki Nakamura; Hideyuki Ujiie; Akihiko Shibaki; Hiraku Suga; Yuichiro Tsunemi; Wataru Nishie; Hiroshi Shimizu

  HUMAN MUTATION, May 2010, Peer-reviewed

  
• Two pathways for lysophosphatidic acid production.

  Junken Aoki; Asuka Inoue; Shinichi Okudaira

  Biochimica et biophysica acta, Sep. 2008, Peer-reviewed

  
• Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice

  Kotaro Hama; Junken Aoki; Asuka Inoue; Tomoko Endo; Tomokazu Amano; Rie Motoki; Motomu Kanai; Xiaoqin Ye; Jerold Chun; Norio Matsuki; Hiroshi Suzuki; Masakatsu Shibasaki; Hiroyuki Arai

  BIOLOGY OF REPRODUCTION, Dec. 2007, Peer-reviewed

  
• Structure and function of extracellular phospholipase A(1) belonging to the pancreatic lipase gene family

  Junken Aoki; Asuka Inoue; Kumiko Makide; Naoya Saiki; Hiroyuki Arai

  BIOCHIMIE, Feb. 2007, Peer-reviewed

  
• Phospholipase A(1): structure, distribution and function

  Asuka Inoue; Junken Aoki

  FUTURE LIPIDOLOGY, Dec. 2006, Peer-reviewed

  
• Lysophosphatidic receptor, LPA(3), is positively and negatively regulated by progesterone and estrogen in the mouse uterus

  Kotaro Hama; Junken Aoki; Koji Bandoh; Asuka Inoue; Tomoko Endo; Tomokazu Amano; Hiroshi Suzuki; Hiroyuki Arai

  LIFE SCIENCES, Sep. 2006, Peer-reviewed

  
• LPA(3)-mediated lysophosphatidic acid signalling in embryo implantation and spacing

  XQ Ye; K Hama; JJA Contos; B Anliker; A Inoue; MK Skinner; H Suzuki; T Amano; G Kennedy; H Arai; J Aoki; J Chun

  NATURE, May 2005, Peer-reviewed

  

Misc.

• 14-3-3とGPCRの相互作用の制御機構とその機能解析

  CARINO Carlo Marion Codog; 桑原莉来; 川上耕季; 柳川正隆; 井上飛鳥; 井上飛鳥

  日本分子生物学会年会プログラム・要旨集(Web), 2024

  
• Analysis of the Molecular Basis of Adverse Effects of Mu-opioid Receptor Agonists

  CARINO Carlo Marion Codog; 平塚寿々音; 中村楽; 川上耕季; 柳川正隆; 井上飛鳥

  日本薬学会年会要旨集(Web), 2024

  
• Ligand recognition and activation mechanisms of Free Fatty Acid Receptor 2

  九川真衣; 木瀬亮次; 福田昌弘; 福田昌弘; 川上耕季; 川上耕季; 川上耕季; 松井俊貴; 小林和弘; 小林和弘; 井上飛鳥; 加藤英明; 加藤英明

  日本薬学会年会要旨集(Web), 2024

  
• β-arrestinのPIP₂新規結合部位の機能解析

  倉本律輝; 生田達也; コドック カリニョ・カーロ・マリオン; 川上耕季; 内田安則; 田口友彦; 柳川正隆; 井上飛鳥

  GPCR研究会プログラム・抄録集, 2024

  
• ニューロテンシン受容体によるGタンパク質活性化過程の可視化

  川上耕季; 小林和弘; 松井俊貴; 福田昌弘; 新井大輝; 辰己茉菜絵; 小柳淳暉; 草木迫司; JANETZKO John; 山下恵太郎; 濡木理; KOBILKA Brian; 井上飛鳥; 加藤英明

  GPCR研究会プログラム・抄録集, 2024

  
• ヒトアセチルコリン受容体M2Rの活性化を制御するホットスポット残基の特定

  杉浦勇也; 生田達也; 住井裕司; 寿野良二; 岩田想; 柴田哲男; 井上飛鳥; 井上飛鳥; 小林拓也; 神取秀樹; 神取秀樹; 片山耕大; 片山耕大

  GPCR研究会プログラム・抄録集, 2024

  
• GPCRとβアレスチンの結合多様性と機能的役割の解析

  中村楽; 桑原莉来; 川上耕季; 井上飛鳥

  日本生化学会大会(Web), 2023

  
• 遊離脂肪酸受容体(FFAR)の脂肪酸受容における鎖長選択性の解明

  九川真衣; 木瀬亮次; 福田昌弘; 川上耕季; 松井俊貴; 小林和弘; 井上飛鳥; 加藤英明; 加藤英明; 加藤英明

  日本生化学会大会(Web), 2023

  
• 構造生物学から見たバソプレシン・オキシトシンの分子理解

  福永彩美; 川上耕季; 小柳淳暉; 福田昌弘; 小林和弘; 松井俊貴; SCOTT Daniel J.; 井上飛鳥; 加藤英明; 加藤英明

  バソプレシン・オキシトシン研究会プログラム・抄録集, 2023

  
• Analysis of αN helix function in Gα protein activation

  新井大輝; 辰己茉菜絵; 生田達也; 川上耕季; 井上飛鳥

  日本薬学会年会要旨集(Web), 2023

  
• Analysis of biased-signal creation substrates and mechanisms in GPCRs

  中村楽; 川上耕季; 生田達也; 井上飛鳥

  日本薬学会年会要旨集(Web), 2023

  
• Novel PIP₂ binding site of β arrestin and its function

  CARINO Carlo Marion Codog; 生田達也; 倉本律輝; 川上耕季; 内田安則; 田口友彦; 井上飛鳥

  日本薬学会年会要旨集(Web), 2023

  
• 短鎖脂肪酸受容体FFAR2のリガンド認識機構と活性化機構の解明

  九川真衣; 木瀬亮次; 福田昌弘; 川上耕季; 松井俊貴; 小林和弘; 井上飛鳥; 加藤英明; 加藤英明

  日本蛋白質科学会年会プログラム・要旨集, 2023

  
• バソプレシン受容体1aによる神経ペプチドホルモン認識の構造基盤

  福永彩美; 小柳淳暉; 福田昌弘; 川上耕季; 松井俊貴; 小林和弘; SCOTT Daniel J.; 井上飛鳥; 加藤英明; 加藤英明

  日本蛋白質科学会年会プログラム・要旨集, 2023

  
• PTH1受容体における内在性リガンドの認識機構と構造ダイナミクス

  小林和弘; 川上耕季; 草木迫司; 郷野弘剛; 富田敦弘; 小林幹; 志甫谷渉; 山下恵太郎; 山下恵太郎; 西澤知宏; 加藤英明; 加藤英明; 井上飛鳥; 濡木理

  日本生化学会大会(Web), 2022

  
• Gαタンパク質を起点したGRK-βアレスチン機能制御機構

  川上耕季; 柳川正隆; 平塚寿々音; 佐甲靖志; 井上飛鳥

  GPCR研究会プログラム・抄録集, 2022

  
• 第三の結合様式におけるβアレスチンの機能の解明

  桑原莉来; 川上耕季; 倉本律輝; 生田達也; 井上飛鳥

  GPCR研究会プログラム・抄録集, 2022

  
• Discovering GPCR genomic variants unique to Japanese people

  鈴木璃子; 生田達也; 川上耕季; 井上飛鳥

  日本分子生物学会年会プログラム・要旨集(Web), 2022

  
• 分子から迫る神経薬理学 Gタンパク質共役型受容体のシグナル伝達-バイアスシグナル創薬の黎明

  川上耕季; 井上飛鳥

  Clinical Neuroscience, 2022

  
• 分子から迫る神経薬理学 GPCRシグナル検出系の開発

  川上耕季; 井上飛鳥

  Clinical Neuroscience, 2022

  
• Toward understanding the role of G-protein signaling

  Ryoji Kise; Yuki Ono; Kouki Kawakami; Asuka Inoue

  Current Opinion in Endocrine and Metabolic Research, Feb. 2021

  
• ヒトメラトニン受容体シグナル伝達複合体のクライオ電子顕微鏡による単粒子解析

  岡本紘幸; 宮内弘剛; 井上飛鳥; RAIMONDI Francesco; 辻本浩一; 草木迫司; 志甫谷渉; 山下恵太郎; 山下恵太郎; 寿野良二; 小林拓也; 岩田想; 岩田想; 西澤知宏; 濡木理

  日本生化学会大会(Web), 2021

  
• Molecular mechanisms underlying μ-opioid receptor agonist-induced adverse effects

  平塚寿々音; 川上耕季; 吉田美沙紀; 青木淳賢; 青木淳賢; 井上飛鳥; 井上飛鳥

  日本薬学会年会要旨集(Web), 2021

  
• NanoBiT-BRET法によるGPCRシグナル複合体解析

  川上耕季; 平塚寿々音; 桑原莉来; 吉田美沙紀; 井上飛鳥

  日本生化学会大会(Web), 2021

  
• GRK3選択的活性化機構の生化学的解析

  カリニョ カーロマリオンコドッグ; 生田達也; 志甫谷渉; 川上耕季; 平塚寿々音; 濡木理; 井上飛鳥

  日本生化学会大会(Web), 2021

  
• ミューオピオイド受容体作動薬の副作用発現を担うシグナル制御因子

  平塚寿々音; 川上耕季; 井上飛鳥

  日本生化学会大会(Web), 2021

  
• バソプレシンV2受容体に対するβアレスチンの結合様式と構造変化

  倉本律輝; 生田達也; 川上耕季; 井上飛鳥

  日本生化学会大会(Web), 2021

  
• βアレスチンの機能多様性の分子機構の解析

  川上耕季; 井上飛鳥

  GPCR研究会プログラム・抄録集, 2021

  
• RNA修飾代謝物のN6-methyladenosine(m6A)は受容体応答を引き起こす新規液性因子である

  小川亜希子; 小川亜希子; 名切千彩恵; 志甫谷渉; 井上飛鳥; 川上耕季; 平塚寿々音; 青木淳賢; 青木淳賢; 伊藤康裕; 鈴木健夫; 鈴木勉; 井上俊洋; 濡木理; 富澤一仁; 魏范研; 魏范研

  日本生化学会大会(Web), 2021

  
• βアレスチンのGPCRへの結合様式の違いによる機能の差異の解明

  桑原莉来; 川上耕季; 吉田美沙紀; 平塚寿々音; 辰己茉菜絵; 井上飛鳥

  日本生化学会大会(Web), 2021

  
• GPCRバイアスリガンドのシグナル機構の理解

  川上耕季; 平塚寿々音; 井上飛鳥; 井上飛鳥

  日本生化学会大会(Web), 2020

  
• Gタンパク質依存的なβアレスチン制御メカニズムの発見と解析

  川上耕季; 柳川正隆; 平塚寿々音; SHUKLA Arun K.; 佐甲靖志; 青木淳賢; 青木淳賢; 青木淳賢; 井上飛鳥; 井上飛鳥; 井上飛鳥

  日本生化学会大会(Web), 2020

  
• μオピオイド受容体におけるGPCRキナーゼの選択的活性化機構の解明

  平塚寿々音; 川上耕季; 吉田美沙紀; 青木淳賢; 青木淳賢; 井上飛鳥; 井上飛鳥

  日本生化学会大会(Web), 2020

  
• NanoBiTを用いたGαq-PLCβ相互作用解析手法の開発とGq共役型受容体の機能解析

  西郷雄貴; 川上耕季; 平塚寿々音; 青木淳賢; 青木淳賢; 井上飛鳥; 井上飛鳥; 井上飛鳥

  日本生化学会大会(Web), 2020

  
• βアレスチン構造センサーを用いたバイアスリガンドとシグナル伝達の解明

  吉田美沙紀; 川上耕季; 平塚寿々音; SHUKLA Arun K.; 青木淳賢; 青木淳賢; 井上飛鳥; 井上飛鳥

  日本生化学会大会(Web), 2020

  
• リゾリン脂質の疎水性部は膜受容体結合時にどこに位置するか

  佐山 美紗; 上水 明治; 井上 飛鳥; 青木 淳賢; 関嶋 政和; 尾谷 優子; 大和田 智彦

  日本薬学会年会要旨集, Mar. 2019

  
• Gαiファミリー欠損細胞を用いたGPCR-Gαiサブタイプの共役の解析

  小野 雄基; 井上 飛鳥; 石田 覚; 川上 耕季; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2019

  
• Non-Edg型LPA受容体LPA4-6及びGPR55の作動薬創製

  金藤 奨; 井上 飛鳥; 可野 邦行; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2019

  
• かゆみや呼吸を制御する酸化リン脂質とその受容体の同定

  吉田美沙紀; 岸貴之; 川名裕己; 川名裕己; 可野邦行; 可野邦行; 仲川清隆; 井上飛鳥; 井上飛鳥; 井上飛鳥; 青木淳賢; 青木淳賢

  次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 2019

  
• GRK欠損HEK293細胞の作製と各種リガンドのGRKサプタイプ選択性評価

  平塚寿々音; 川上耕季; 井上飛鳥; 井上飛鳥; 青木淳賢; 青木淳賢

  日本生化学会大会(Web), 2019

  
• GPCRキナーゼ解析ツールの開発とバイアス型リガンドの解析

  川上耕季; 川上耕季; 井上飛鳥; 井上飛鳥; 井上飛鳥; 平塚寿々音; 青木淳賢; 青木淳賢

  日本生化学会大会(Web), 2019

  
• GRK解析ツールの開発とバイアス型リガンドの理解

  川上耕季; 川上耕季; 井上飛鳥; 井上飛鳥; 平塚寿々音; 青木淳賢; 青木淳賢

  GPCR研究会プログラム・抄録集, 2019

  
• Gタンパク質共役選択性の理解

  井上飛鳥; 井上飛鳥; 井上飛鳥; RAIMONDI Francesco; KADJI Francois Marie Ngako; SINGH Gurdeep; 岸貴之; 上水明治; 小野雄基; 新上雄司; 石田覚; ARANG Nadia; 川上耕季; GUTKIND J.Silvio; 青木淳賢; 青木淳賢; RUSSELL Robert B.

  GPCR研究会プログラム・抄録集, 2019

  
• GPCR-Gタンパク質共役データベースを利用したG12選択的DREADDの作製

  小野雄基; 井上飛鳥; 井上飛鳥; 井上飛鳥; RAIMONDI Francesco; KADJI Francois Marie Ngako; SINGH Gurdeep; 岸孝之; 上水明治; 新上雄司; 石田覚; ARANG Nadia; 川上耕季; GUTKIND J Silvio; 青木淳賢; RUSSELL Roberet B.

  GPCR研究会プログラム・抄録集, 2019

  
• 【リゾリン脂質メディエーター研究の最前線】生理活性脂質LysoPSの受容体と代謝酵素

  井上 飛鳥; 上水 明治; 青木 淳賢

  生化学, Oct. 2018

  
• スプリットルシフェラーゼを用いた三量体Gタンパク質活性化の検出法の確立とGPCR研究への応用

  井上 飛鳥; Kadji Francois; Marie Ngako; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• 脂質酸化を起点とするバイオロジーの新展開 酸化リン脂質の新規薬理作用とその受容体

  岸 貴之; 井上 飛鳥; 石黒 純; 大村谷 昌樹; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• ロイコトリエンB4受容体のリン酸化修飾に関する解析 昨年からの続報

  竹之下 逸樹; 相原 咲希; 井上 飛鳥; 青木 淳賢; 中村 元直

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• オーファンGPCRに対するGαタンパク質共役解析

  川上 耕季; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• Gαi欠損HEK293細胞の作製と評価

  小野 雄基; 井上 飛鳥; 石田 覚; 川上 耕季; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• ATX-LPAシグナルによる内分細胞間接着制御機構の解析

  木瀬 亮次; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• LPAによる昇圧作用メカニズムの解析

  可野 邦行; 松本 宏隆; 井上 飛鳥; 雪浦 弘志; Chun Jerold; 石井 聡; 清水 孝雄; 青木 淳賢

  脂質生化学研究, May 2018

  
• LPA6およびPA‐PLA1aは毛包の特定の層に発現し正常な体毛形成に寄与する

  片寄愛望; 可野邦行; 可野邦行; 井上飛鳥; 井上飛鳥; 青木淳賢; 青木淳賢; 青木淳賢

  日本薬学会年会要旨集(CD-ROM), Mar. 2018

  
• 脂質リガンドのGPCRへの結合機構の解明のための誘導体合成と計算科学の融合研究

  佐山 美紗; 井上 飛鳥; 青木 淳賢; 広川 貴次; 関嶋 政和; 尾谷 優子; 大和田 智彦

  日本薬学会年会要旨集, Mar. 2018

  
• アミノ酸点変異導入による新規GPCR活性化手法の開発

  柴田 剛明; 井上 飛鳥; 川上 耕季; 木瀬 亮次; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2018

  
• 初代培養リンパ球を用いたリゾホスファチジルセリン産生機構の解析

  佐藤 慧太; 新上 雄司; 尾谷 優子; 大和田 智彦; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2018

  
• LPA6およびPA-PLA1aは毛包の特定の層に発現し正常な体毛形成に寄与する

  片寄 愛望; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2018

  
• 全Giファミリー分子欠損細胞の作製とGi共役型受容体シグナルの解析

  小野雄基; 井上飛鳥; 石田覚; 川上耕季; 青木淳賢

  次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 2018

  
• TGFα切断アッセイ系を活用したロイコトリエンB4受容体のシグナル伝達解析について

  瀬川 美奈; 井上 飛鳥; 青木 淳賢; 中村 元直

  生命科学系学会合同年次大会, Dec. 2017

  
• Gαi欠損HEK293細胞の作成

  小野 雄基; 井上 飛鳥; 石田 覚; 川上 耕季; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• Non-Edg型LPA受容体LPA4-6の作動薬創製

  金藤 奨; 井上 飛鳥; 尾谷 優子; 大和田 智彦; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• ゼブラフィッシュにおけるGPCR活性化検出系の確立

  柴田 剛明; 井上 飛鳥; 木瀬 亮次; 川上 耕季; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• ATX-LPAシグナルは細胞間接着の形成に重要である

  木瀬 亮次; 新上 雄司; 可野 邦行; 井上 飛鳥; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• がん細胞の代謝がもたらす組織微小環境を標的にしたがん治療

  豊本 雅靖; 井上 飛鳥; 飯田 慶; 出縄 政嗣; 喜井 勲; 林 佳子; 岸 貴之; 小野木 博; 吉田 優; 細谷 孝充; 青木 淳賢; 萩原 正敏

  生命科学系学会合同年次大会, Dec. 2017

  
• 三量体Gタンパク質の活性化センサーの開発

  井上 飛鳥; Francois Marie Kadji; 川上 耕季; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• 酸化脂質に応答する霊長類特異的受容体、MRGX4のマウス機能的ホモログの同定

  岸 貴之; 井上 飛鳥; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• 3.43Q変異に起因する恒常活性化GPCRの性状解析

  川上 耕季; 井上 飛鳥; 柴田 剛明; 青木 淳賢

  生命科学系学会合同年次大会, Dec. 2017

  
• LPAシグナルは細胞形態の維持に重要である

  木瀬 亮次; 川上 耕季; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本細胞生物学会大会講演要旨集, May 2017

  
• 常染色体劣性縮毛症/乏毛症(ARWH/H)の遺伝子解析 診断に有用なアッセイ系の確立

  林 良太; 阿部 理一郎; 下村 裕; 井上 飛鳥; 青木 淳賢; 須賀 康; 赤坂 俊英

  日本皮膚科学会雑誌, Apr. 2017

  
• 酸化脂質に応答するオーファンGPCR、MRGX4のマウスにおける機能的ホモログの同定

  岸 貴之; 井上 飛鳥; 石黒 純; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2017

  
• ATX-LPAシグナルはVE-cadherin機能調節を介して血管新生を制御する

  木瀬 亮次; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2017

  
• PA-PLA1aおよびLPA6は毛包の特定の層に発現し正常な体毛形成に寄与する

  片寄 愛望; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2017

  
• 恒常活性がみられるGPCRの発現解析

  柴田 剛明; 井上 飛鳥; 川上 耕季; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2017

  
• 多数のGPCRを共通に活性化させる変異の解析

  川上 耕季; 井上 飛鳥; 柴田 剛明; 金藤 奨; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2017

  
• ポストGPCRシグナル創薬全盛期世代の研究戦略 GPCRシグナルを基軸とした創薬基礎研究

  井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2017

  
• 3.43Q変異に起因する恒常活性化GPCRの解析

  川上耕季; 井上飛鳥; 井上飛鳥; 井上飛鳥; 柴田剛明; 青木淳賢; 青木淳賢

  GPCR研究会プログラム・抄録集, 2017

  
• 恒常活性化変異GPCRの性状解析

  川上耕季; 井上飛鳥; 井上飛鳥; 井上飛鳥; 柴田剛明; 青木淳賢; 青木淳賢

  次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 2017

  
• 高輝度スプリットルシフェラーゼを用いたGタンパク質センサー

  井上飛鳥; 井上飛鳥; 井上飛鳥; KADJI Francois Marie; 川上耕季; 青木淳賢; 青木淳賢

  GPCR研究会プログラム・抄録集, 2017

  
• 恒常活性がみられる点変異GPCRの発現解析

  柴田剛明; 井上飛鳥; 井上飛鳥; 井上飛鳥; 川上耕季; 青木淳賢; 青木淳賢

  GPCR研究会プログラム・抄録集, 2017

  
• 酸化リン脂質により活性化する3種のオーファンGPCRの同定

  岸 貴之; 井上 飛鳥; 石黒 純; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• アカデミア発創薬探索研究 GPCR解析ツールの開発とGPCRを標的とするアカデミア創薬

  井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• 全LPA受容体欠損細胞の作製とLPA研究への応用

  川上 耕季; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• PA-PLA1αおよびLPA6は毛包の特定の層に発現し正常な体毛形成に寄与する

  片寄 愛望; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• LPA6の欠損は精原細胞の減少を引き起こす

  岸田 真輝; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• 新規LysoPS受容体の抗体産生における役割

  新上 雄司; 巻出 久美子; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• 腫瘍免疫におけるリゾホスファチジルセリンの役割

  巻出 久美子; 新上 雄司; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• 腸内細菌の長鎖不飽和脂肪酸代謝物によるGPR120活性化の検討

  本郷 翔子; 森本 育美; 山上 小百合; 古田 美咲; 滝澤 祥恵; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 岸野 重信; 小川 順; 中田 理恵子; 井上 裕康

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• 生命科学研究の必要条件としての構造生物学 オートタキシン-ENPP2シグナリングの構造と機能、そして構造に基づいた創薬

  濡木 理; 谷口 怜哉; 加藤 一希; 西増 弘志; 井上 飛鳥; 青木 淳賢; 石谷 隆一郎

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• GPR35を介したマスト細胞の脱顆粒応答抑制機構の解明

  水粉 翔也; 古田 和幸; 井上 飛鳥; 青木 淳賢; 田中 智之

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• リゾホスファチジルセリン受容体LPS1/GPR34に対する強力且つ選択的アゴニストの開発とその応用

  上水 明治; 巻出 久美子; 中村 翔; 井上 飛鳥; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• Implications of Spns2-deficiency on S1P-driven lymphocytes egress, HEV-integrity and immunity

  S. Simmons; N. Sasaki; E. Umemoto; N. Yoshizumi; S. Fukuhara; Y. Kitazawa; M. Okudaira; A. Inoue; D. Motooka; S. Nakamura; T. Iida; J. Aoki; N. Mochizuki; K. Matsuno; K. Takeda; M. Miyasaka; M. Ishii

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• 長鎖不飽和脂肪酸とその腸内細菌代謝物によるGPR120活性化の検討

  本郷 翔子; 森本 育美; 山上 小百合; 古田 美咲; 滝澤 祥恵; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 岸野 重信; 小川 順; 中田 理恵子; 井上 裕康

  脂質生化学研究, May 2016

  
• 内皮細胞におけるATX-LPAシグナルの解析

  木瀬 亮次; 可野 邦行; 井上 飛鳥; 青木 淳賢

  脂質生化学研究, May 2016

  
• ヒト先天性乏毛症患者由来の変異LPA6受容体の機能解析

  上水 明治; 井上 飛鳥; 下村 裕; 青木 淳賢

  脂質生化学研究, May 2016

  
• マスト細胞上のLysoPS受容体探索ツールの開発

  岸 貴之; 佐山 美沙; 巻出 久美子; 川名 裕己; 井上 飛鳥; 尾谷 優子; 大和田 知彦; 青木 淳賢

  脂質生化学研究, May 2016

  
• 「疾患代謝」から解明される生命現象と創薬研究への応用 代謝物が作用するGPCRの同定と機能解析

  井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2016

  
• リゾリン脂質のGPCRへの結合様式解明のための誘導体合成

  佐山 美紗; ジョン・セジン; 中村 翔; 井久保 仁也; 尾谷 優子; 上水 明治; 岸 貴之; 井上 飛鳥; 巻出 久美子; 青木 淳賢; 広川 貴次; 大和田 智彦

  日本薬学会年会要旨集, Mar. 2016

  
• β-arrestin欠損細胞の作製とGPCR研究への応用

  川上耕季; 井上飛鳥; 井上飛鳥; 石田覚; 青木淳賢

  GPCR研究会プログラム・抄録集, 2016

  
• 【GPCR研究の最前線2016】GPCR研究のあらたな基盤と視点 構造・機能解析の進歩 オーファンGPCRのリガンド同定と新規GPCR活性化検出法

  井上 飛鳥; 青木 淳賢

  医学のあゆみ, Jan. 2016

  
• CRISPR/Cas9システムを用いたLysoPS受容体TKOマウスの作製

  新上 雄司; 井上 飛鳥; 巻出 久美子; 中島 修; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• TGFα切断アッセイを用いたGPCRリガンドスクリーニング

  岸 貴之; 井上 飛鳥; 石黒 純; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• LysoPS受容体のサブタイプ選択的アゴニストの開発

  上水 明治; 井上 飛鳥; 井久保 仁也; 中村 翔; ジョン・セジン; 佐山 美紗; 岸 貴之; 巻出 久美子; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• ATX-LPAシグナルによる血管形成制御機構の解析

  木瀬 亮次; 可野 邦行; 井上 飛鳥; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• GPR120活性化を指標とする新規食品機能評価系の検討

  森本 育美; 滝澤 祥恵; 本郷 翔子; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 中田 理恵子; 井上 裕康

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• GPCRの共役するGタンパク質の網羅的解析とその応用

  井上 飛鳥; 新上 雄司; 岸 貴之; 石田 覚; 上水 明治; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• リゾホスファチジン酸の昇圧作用メカニズムの解析

  可野 邦行; 井上 飛鳥; 松本 宏隆; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• GPCRシグナル解析ツールの開発

  石田 覚; 井上 飛鳥; 新上 雄司; 川上 耕季; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• 第二世代の脂質メディエーター・リゾリン脂質の生理・病態機能

  青木淳賢; 青木淳賢; 可野邦行; 井上飛鳥; 井上飛鳥

  生体膜と薬物の相互作用シンポジウム講演要旨集, 19 Nov. 2015

  
• 【代謝疾患とメタボローム】代謝物が作用するGPCRをどのように同定するか?

  岸 貴之; 井上 飛鳥; 青木 淳賢

  内分泌・糖尿病・代謝内科, Nov. 2015

  
• 【脂質疾患学 なぜ"あぶら"の異常が病気を引き起こすのか?その質的量的変化と肥満、がん、不妊症、免疫・皮膚・神経疾患】(第2章)多彩な疾患における脂質の量的・質的変化 皮膚疾患 リゾホスファチジン酸と先天性乏毛症

  下村 裕; 井上 飛鳥; 青木 淳賢

  実験医学, Sep. 2015

  
• 酸化リン脂質に応答するGPCRの同定および機能解析

  青木 淳賢; 石黒 純; 井上 飛鳥

  ビタミン, Jul. 2015

  
• ATX-LPAシグナルによる血管形成制御機構の解析

  木瀬 亮次; 雪浦 弘志; 可野 邦行; 井上 飛鳥; 青木 淳賢

  脂質生化学研究, May 2015

  
• 4価型人工ペプチドを用いたホスファチジン酸結合プローブの開発

  小川 莉奈; 長尾 耕治郎; 原 雄二; 田村 朋則; 浜地 格; 井上 飛鳥; 青木 淳賢; 高橋 美帆; 西川 喜代孝; 梅田 真郷

  脂質生化学研究, May 2015

  
• TGFα切断アッセイを用いたω-3系脂肪酸によるGPR120活性化

  森本 育美; 滝澤 祥恵; 本郷 翔子; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 中田 理恵子; 井上 裕康

  ビタミン, Apr. 2015

  
• リゾホスファチジルセリン分解系の解析

  川名 裕己; 奥平 倫世; 井上 飛鳥; 巻出 久美子; 三枝 大輔; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2015

  
• Gタンパク質欠損細胞を用いたGPCR-Gαサブユニットの共役の解析

  岸 貴之; 井上 飛鳥; 新上 雄司; 上水 明治; 石田 覚; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2015

  
• リゾホスファチジルセリン特異的GPCR-リガンド結合モデルの構築と合成リガンドによる検証

  佐山美紗; ジョン セジン; 中村翔; 井久保仁也; 尾谷優子; 上水明治; 岸貴之; 井上飛鳥; 巻出久美子; 青木淳賢; 広川貴次; 大和田智彦

  日本薬学会年会要旨集(CD-ROM), 2015

  
• β-arrestin欠損細胞の作製

  川上耕季; 井上飛鳥; 井上飛鳥; 石田覚; 青木淳賢; 青木淳賢

  日本薬学会東北支部大会講演要旨集, 2015

  
• Lysophospholipid mediators: Their receptors and synthetic pathways

  Kuniyuki Kano; Kumiko Makide; Jun Ishiguro; Hiroshi Yukiura; Shizu Aikawa; Akiharu Uwamizu; Yuji Shinjo; Kahori Namiki; Hiroki Kawana; Saki Nemoto; Hirotaka Matsumoto; Ryoji Kise; Asuka Inoue; Junken Aoki

  Bioactive Lipid Mediators: Current Reviews and Protocols, 01 Jan. 2015

  
• ヒト先天性脱毛症モデルマウスLPA6KOマウスにおける毛包の解析

  片寄愛望; 可野邦行; 可野邦行; 井上飛鳥; 青木淳賢; 青木淳賢

  日本薬学会東北支部大会講演要旨集, 2015

  
• LPA₆欠損マウスにおける精巣の形成不全の解析

  岸田真輝; 可野邦行; 可野邦行; 井上飛鳥; 青木淳賢; 青木淳賢

  日本薬学会東北支部大会講演要旨集, 2015

  
• 下水からの医薬品生理活性の検出

  井原 賢; 井上 飛鳥; 花本 征也; Zhang Han; 青木 淳賢; 田中 宏明

  環境ホルモン学会研究発表会要旨集, Dec. 2014

  
• LysoPS受容体アゴニストの探索 LysoPS類似体を用いたアプローチ

  上水 明治; 井上 飛鳥; 井久保 仁也; 中村 翔; セジン・ジョン; 佐山 美紗; 岸 貴之; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• CRISPR-Cas9システムを用いたLysoPS受容体変異Jurkat T cellの作製

  新上 雄司; 井上 飛鳥; 石黒 純; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• TALENによるLPA4欠損ゼブラフィッシュの作製

  木瀬 亮次; 雪浦 弘志; 可野 邦行; 井上 飛鳥; 久野 悠; 川原 敦雄; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• リゾホスファチジルセリンはTリンパ球の活性化を抑制する

  石黒 純; 新上 雄司; 北村 一; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• 自己免疫性リンパ球増殖症におけるP2Y10の機能解析

  奥平 倫世; 根本 祥李; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• 三量体Gタンパク質欠損細胞を用いたGPCRのシグナル解析手法の確立

  井上 飛鳥; 新上 雄司; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• コンカナバリンA誘発性肝炎におけるリゾホスファチジルセリン産生機構の解析

  丹羽 祐介; 鈴木 健介; 奥平 倫世; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Oct. 2014

  
• 【GPCR研究の熱い潮流】新しいGPCR活性化測定法"TGFα切断アッセイ" その発見の経緯と薬学研究における応用

  井上 飛鳥; 青木 淳賢

  ファルマシア, Sep. 2014

  
• Lipase H(LIPH)の新しい遺伝子変異c.699C>G(p.C233W)による先天性縮毛症・乏毛症の1例

  吉岡 学; 吉澤 真裕子; 日野 亮介; 小林 美和; 中村 元信; Muhammmmad Farooq; 下村 裕; 井上 飛鳥; 青木 淳賢

  西日本皮膚科, Jun. 2014

  
• コンカナバリンA誘発性肝炎におけるリゾホスファチジルセリンの役割

  巻出 久美子; 鈴木 健介; 奥平 倫世; 井上 飛鳥; 青木 淳賢

  脂質生化学研究, May 2014

  
• 血小板活性化の血漿リゾフォスファチジルセリン上昇への関与

  蔵野 信; 廣渡 祐史; 徳原 康哲; 土肥 智貴; 宮内 克己; 代田 浩之; 五十嵐 浩二; 井上 飛鳥; 青木 淳賢; 矢冨 裕

  日本血栓止血学会誌, Apr. 2014

  
• Physiological roles of lysophosphatidic acid (LPA)

  井上 飛鳥

  医学のあゆみ, 29 Mar. 2014

  
• 創薬標的分子の同定を目指す新しい脂質マシナリー研究 免疫系を制御する新たな脂質メディエーターリゾホスファチジルセリン

  青木 淳賢; 巻出 久美子; 井上 飛鳥

  日本薬学会年会要旨集, Mar. 2014

  
• TGFα切断アッセイのハイスループットスクリーニングへの応用

  上水 明治; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2014

  
• 血中におけるリゾホスファチジルセリンの安定性の解析

  奥平 倫世; 飯田 奈紀沙; 井上 飛鳥; 巻出 久美子; 中村 翔; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2014

  
• リゾリン脂質受容体における疎水性ポケット構造の推定

  佐山美紗; セジン ジョン; 中村翔; 井久保仁也; 尾谷優子; 上水明治; 井上飛鳥; 巻出久美子; 青木淳賢; 広川貴次; 大和田智彦

  日本薬学会関東支部大会講演要旨集, 2014

  
• 新規GPCR活性化検出法を利用したオーファン受容体のリガンドの同定

  井上 飛鳥; 青木 淳賢

  生化学, Nov. 2013

  
• 【ホスホリパーゼの機能・応用】ホスホリパーゼA1の構造と機能

  中永 景太; 井上 飛鳥; 青木 淳賢

  オレオサイエンス, Oct. 2013

  
• 細胞内型ホスホリパーゼA1の機能解析

  中永 景太; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• 軟骨形成におけるATX-LPA-LPA1 axisの役割

  西岡 達二; 板井 恵理子; 有馬 直明; 井上 飛鳥; Chun Jerold; Moolenaar Wouter; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• コンカナバリンA誘導肝炎におけるリゾホスファチジルセリンの機能解析

  鈴木 健介; 奥谷 倫世; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• LysoPSはGPR174を介してIL-2産生を抑制する

  新上 雄司; 北村 一; 石黒 純; 奥谷 倫世; 井上 飛鳥; 巻出 久美子; 井久保 仁也; 大和田 智彦; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• リゾホスファチジルセリンは活性化リンパ球の増殖を抑制する

  石黒 純; 北村 一; 首藤 啓明; 新上 雄司; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• LPAはLPA6を介してVE-cadherinによる血管内皮細胞間接着を抑制する

  雪浦 弘志; 中永 景太; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• 生体膜におけるリン脂質分子種の非対称分布

  石川 真実; 加藤 詩子; 芦本 徹; 井上 飛鳥; 青木 淳賢; 梅田 真郷

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• オートファゴソーム形成とグリセロリン脂質生合成系の密接な関係

  西村 多喜; 田村 律人; 中永 景太; 井上 飛鳥; 青木 淳賢; 水島 昇

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• TGFα切断アッセイのハイスループットスクリーニングへの応用

  上水 明治; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• 血中におけるリゾホスファチジルセリンの安定性の解析

  奥平 倫世; 飯田 奈紀沙; 井上 飛鳥; 巻出 久美子; 中村 翔; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• 機能性酸化脂質研究の新展開 酸化リン脂質によるGタンパク質共役型受容体の活性化とその意義

  井上 飛鳥; 石黒 純; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• 細胞内型ホスホリパーゼA1の機能解析

  中永 景太; 井上 飛鳥; 青木 淳賢

  生化学, Aug. 2013

  
• LysoPSはGPR174を介してT細胞のIL-2産生を抑制する

  新上 雄司; 奥谷 倫世; 石黒 純; 北村 一; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  生化学, Aug. 2013

  
• LRATにホモロジーを示す新規リン脂質代謝酵素による細胞内ペルオキシソーム含量の調節

  宇山 徹; 坪井 一人; 金 星華; 上田 夏生; 市 育代; 河野 望; 新井 洋由; 井上 飛鳥; 青木 淳賢; 荒木 伸一

  ビタミン, Jun. 2013

  
• Close Up実験法(Series 238) TGFα切断を用いたGPCRの高感度・高精度な活性化検出法

  井上 飛鳥; 青木 淳賢

  実験医学, May 2013

  
• 【最新生理活性脂質研究-実験手法、基礎的知識とその応用-】(第1章)技術編 リゾリン脂質の質量分析解析

  奥平 倫世; 井上 飛鳥; 青木 淳賢

  遺伝子医学MOOK, May 2013

  
• 【最新生理活性脂質研究-実験手法、基礎的知識とその応用-】(第3章)基礎編 リゾリン脂質に対する受容体

  可野 邦行; 井上 飛鳥; 石黒 純; 青木 淳賢

  遺伝子医学MOOK, May 2013

  
• 酸化脂質研究の最前線 疾患シグナルとしての酸化リン脂質と新たな解析法 酸化リン脂質を認識するGタンパク質共役型受容体

  井上 飛鳥; 石黒 純; 青木 淳賢

  脂質生化学研究, May 2013

  
• 細胞内型ホスホリパーゼA1の機能解析

  中永 景太; 井上 飛鳥; 青木 淳賢

  脂質生化学研究, May 2013

  
• LysoPSの検出系の確立と生体内におけるLysoPSの検出

  奥平 倫世; 井上 飛鳥; 三枝 大輔; 富岡 佳久; 巻出 久美子; 青木 淳賢

  脂質生化学研究, May 2013

  
• LRATに相同性を示す新規リン脂質代謝酵素によるペルオキシソームの機能調節

  宇山 徹; 市 育代; 河野 望; 井上 飛鳥; 坪井 一人; 荒木 伸一; 青木 淳賢; 新井 洋由; 上田 夏生

  ビタミン, Apr. 2013

  
• keratin71遺伝子に病的変異を同定し得た常染色体優性縮毛症/乏毛症(autosomal dominant woolly hair/hypotrichosis)の1家系

  藤本 篤; 藤川 大基; 伊藤 雅章; ファルーク・モハメド; 下村 裕; 井上 飛鳥; 青木 淳賢; 大山 学; 江浜 律子; 仲西 城太郎; 萩原 基文; 岩渕 徳郎

  日本皮膚科学会雑誌, Apr. 2013

  
• 脂質バイオロジーの最前線 Lipid phophate phosphatase 3による血管形成制御

  雪浦 弘志; 濱 弘太郎; 中永 景太; 井上 飛鳥; 奥平 真一; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2013

  
• リゾホスファチジルセリン受容体アゴニストの配座に関する研究

  中村 翔; 鄭 世珍; 井久保 仁也; 尾谷 優子; 上水 明治; 井上 飛鳥; 巻出 久美子; 青木 淳賢; 大和田 智彦

  日本薬学会年会要旨集, Mar. 2013

  
• 自己免疫性肝炎モデルにおけるリゾホスファチジルセリンの薬理作用

  巻出 久美子; 鈴木 健介; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2013

  
• TGFα切断を用いたGPCRと三量体Gタンパク質の共役活性の評価系の確立

  井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2013

  
• リゾホスファチジン酸LPAの昇圧作用メカニズムの解析

  松本宏隆; 可野邦行; 井上飛鳥; 青木淳賢

  日本薬学会東北支部大会講演要旨集, 2013

  
• 生体膜リン脂質の新たな個性に迫る セリンリゾリン脂質を認識する新規GPCRとその機能

  青木 淳賢; 巻出 久美子; 井上 飛鳥

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• 新規脂質メディエーターが制御する多彩な機能 毛髪形成メカニズムから派生したGタンパク質共役型受容体(GPCR)の新規検出系の開発とその応用

  井上 飛鳥; 石黒 純; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• 細胞内型ホスホリパーゼA1の機能解析

  中永 景太; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• Lipid phosphate phosphatase 3(LPP3)による血管形成制御機構の解析

  雪浦 弘志; 濱 弘太郎; 奥平 真一; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• PS特異的ホスホリパーゼA1(PS-PLA1)を用いた新規細胞表面ホスファチジルセリン検出系の確立

  橋本 崇史; 井上 飛鳥; 奥谷 倫世; 有馬 直明; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• Phospholipase A/Acyltransferaseファミリーによる細胞内ペルオキシソーム含量の制御

  宇山 徹; 市 育代; 河野 望; 井上 飛鳥; 井上 愛美; 坪井 一人; 金 星華; 荒木 伸一; 青木 淳賢; 徳村 彰; 新井 洋由; 上田 夏生

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• 新規リゾホスファチジルセリン受容体の発現解析

  石黒 純; 新上 雄司; 北村 一; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• ゼブラフィッシュカルシウム動員系プロスタノイド受容体の性状解析

  岩崎 亮; 川原 敦雄; 井上 飛鳥; 青木 淳賢; 土屋 創建; 杉本 幸彦

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• 軟骨形成におけるLPA signalの機能解析

  板井 恵理子; 有馬 直明; 濱 弘太郎; 井上 飛鳥; 奥平 真一; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• 急性冠症候群における血漿リゾホスファチジン酸増加機序の検討 LC/MSによるリゾリン脂質分子種解析

  蔵野 信; 鈴木 明子; 大川 龍之介; 中村 和宏; 土肥 智貴; 宮内 克己; 代田 浩之; 井上 飛鳥; 青木 淳賢; 池田 均; 矢冨 裕

  臨床病理, Oct. 2012

  
• LC/MS/MSを用いたスフィンゴシン-1-リン酸の超高感度分析法について

  高橋 友大; 三枝 大輔; 陣野 大輔; 井上 飛鳥; 奥谷 倫代; 青木 淳賢; 鈴木 直人; 富岡 佳久

  JSBMS Letters, Sep. 2012

  
• LC/MS/MSを用いたマウス脳組織中スフィンゴシン一リン酸の超高感度定量分析について

  三枝 大輔; 高橋 友大; 大宅 史織; 井上 飛鳥; 奥谷 倫代; 鈴木 直人; 眞野 成康; 青木 淳賢; 富岡 佳久

  JSBMS Letters, Sep. 2012

  
• 体毛形成に関与する生理活性脂質リゾホスファチジン酸の機能解明

  井上 飛鳥; 有馬 直明; 石黒 純; Prestwich GD; 新井 洋由; 青木 淳賢

  生化学, Jun. 2012

  
• 生理活性脂質リゾホスファチジルセリンによる免疫抑制作用

  巻出 久美子; 北村 一; 井上 飛鳥; 青木 淳賢

  生化学, Jun. 2012

  
• 新規脂質代謝酵素H-rev107の発現はペルオキシソームの機能異常を引き起こす

  宇山 徹; 市 育代; 河野 望; 井上 飛鳥; 坪井 一人; 金 星華; 荒木 伸一; 青木 淳賢; 新井 洋由; 上田 夏生

  脂質生化学研究, May 2012

  
• 細胞内リゾホスファチジン酸によるミトコンドリアの形態制御

  大場 陽介; 井上 貴雄; 櫻木 健司; 原 直子; 中臺 枝里子; 井上 飛鳥; 石原 直忠; 青木 淳賢; 三谷 昌平; 新井 洋由

  脂質生化学研究, May 2012

  
• TGFα切断を用いた脂質メディエーター受容体の検出法の開発

  井上 飛鳥; 石黒 純; 巻出 久美子; 青木 淳賢

  脂質生化学研究, May 2012

  
• 酸化リン脂質に応答する新規GPCRの同定

  石黒 純; 井上 飛鳥; 青木 淳賢

  脂質生化学研究, May 2012

  
• リゾホスファチジルセリンは自己免疫性肝炎を緩和させる

  鈴木 健介; 北村 一; 奥谷 倫世; 首藤 啓明; 巻出 久美子; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2012

  
• 酸化リン脂質に応答する新規GPCRの同定

  石黒 純; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2012

  
• 生体内におけるリゾホスファチジルセリンの検出

  奥谷 倫世; 井上 飛鳥; 巻出 久美子; 三枝 大輔; 富岡 佳久; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2012

  
• LC/MS/MSを用いた生体試料中スフィンゴ脂質同時定量法の構築

  芝 可奈子; 三枝 大輔; 井上 飛鳥; 濱 弘太郎; 奥谷 倫世; 鈴木 千登世; 佐藤 恵美子; 眞野 成康; 菱沼 隆則; 鈴木 直人; 佐藤 博; 阿部 高明; 青木 淳賢; 富岡 佳久

  日本薬学会年会要旨集, Mar. 2012

  
• 常染色体劣性乏毛症患者に高頻度に認められたLIPH founder変異とその機能解析

  新熊 悟; 秋山 真志; 夏賀 健; 乃村 俊史; 有田 賢; 西江 渉; 清水 宏; 井上 飛鳥; 青木 淳賢

  日本皮膚科学会雑誌, Feb. 2012

  
• ゼブラフィッシュプロスタノイド受容体の性状解析

  告 恭史郎; 岩崎 亮; 川原 敦雄; 井上 飛鳥; 青木 淳賢; 杉本 幸彦

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• ホスホリパーゼA1(PLA1)によって産生される2-アシル型リゾリン脂質の性状解析

  首藤 啓明; 井上 飛鳥; 奥谷 倫世; 北村 一; 有馬 直明; 巻出 久美子; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• グリセロ脂質de novo合成系で産生されるLPAはミトコンドリアの形態を制御する

  大場 陽介; 井上 貴雄; 櫻木 健司; 原 直子; 井上 飛鳥; 岡 敏彦; 石原 直忠; 中臺 枝里子; 青木 淳賢; 三谷 昌平; 新井 洋由

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• 生理活性リゾリン脂質の定量系の開発と産生機構の解析

  井上 飛鳥; 奥谷 倫世; 三枝 大輔; 奥平 真一; 鈴木 直人; 富岡 佳久; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• 新規GPCRシグナル検出法-TGFα切断アッセイ-の開発

  石黒 純; 井上 飛鳥; 有馬 直明; 首藤 啓明; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• 骨形成におけるLPAシグナリングの役割の解明

  板井 恵理子; 有馬 直明; 濱 弘太郎; 井上 飛鳥; 奥平 真一; Chun Jerold; Moolenaar Wouter; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• リゾホスファチジルセリンの細胞接着抑制作用

  北村 一; 巻出 久美子; 井上 飛鳥; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• リゾホスファチジルセリンの免疫抑制作用

  奥谷 倫世; 巻出 久美子; 井上 飛鳥; 中嶋 千紗; 椛島 健治; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• LC/MS/MSを用いた脂質関連物質分離分析系の構築

  三枝 大輔; 芝 可奈子; 井上 飛鳥; 濱 弘太郎; 青木 淳賢; 鈴木 直人; 富岡 佳久

  JSBMS Letters, Aug. 2011

  
• 【リン脂質代謝と脂質メディエーター研究の最新の成果】 (第2部)リゾリン脂質を中心とした脂質メディエーター 新しいリゾリン脂質メディエーターリゾホスファチジルセリン

  井上 飛鳥; 奥谷; 倫世; 青木 淳賢

  生化学, Jun. 2011

  
• リゾホスファチジン酸産生酵素オートタキシンの結晶構造解析

  奥平 真一; 西増 弘志; 濱 弘太郎; 三原 恵美子; 堂前 直; 井上 飛鳥; 石谷 隆一郎; 高木 淳一; 濡木 理; 青木 淳賢

  脂質生化学研究, Apr. 2011

  
• 骨形成におけるLPAシグナリングの役割の解明

  板井 恵理子; 有馬 直明; 濱 弘太郎; 井上 飛鳥; 奥平 真一; Chun Jerold; Moolenaar Wouter; 青木 淳賢

  脂質生化学研究, Apr. 2011

  
• ホスホリパーゼA1(PLA1)により産生される2-アシル型リゾリン脂質の分離とその性状解析

  首藤 啓明; 井上 飛鳥; 奥谷 倫世; 北村 一; 有馬 直明; 巻出 久美子; 青木 淳賢

  脂質生化学研究, Apr. 2011

  
• 新規GPCRシグナル検出法-TGFα切断アッセイ-の開発

  石黒 純; 井上 飛鳥; 有馬 直明; 首藤 啓明; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2011

  
• 生体内におけるリゾホスファチジルセリンの検出

  奥谷 倫世; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2011

  
• モデル生物を用いたLPAシグナルの作用機序の解析

  濱 弘太郎; 中永 景太; 雪浦 弘志; 有馬 直明; 奥平 真一; 井上 飛鳥; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2011

  
• LC-ESI-MS/MSを用いた生理活性リゾリン脂質の定量系の開発

  井上 飛鳥; 奥谷 倫世; 三枝 大輔; 奥平 真一; 鈴木 直人; 富岡 佳久; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2011

  
• 生命応答を制御する脂質マシナリー ゼブラフィッシュにおけるリゾホスファチジン酸シグナル(Lipid machineries that regulate biological responses Lysophosphatidic acid signaling in zebra fish)

  濱 弘太郎; 中永 景太; 井上 飛鳥; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• LC-ESI-MS/MSをリゾリン脂質定量系の開発

  井上 飛鳥; 三枝 大輔; 奥谷 倫世; 鈴木 直人; 富岡 佳久; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• リゾホスファチジルセリンの活性化リンパ球に対する効果

  北村 一; 巻出 久美子; 井上 飛鳥; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• LC-ESI-MS/MSを用いたリゾホスファチジルセリンおよびリゾホスファチジルスレオニンの検出

  奥谷 倫世; 井上 飛鳥; 巻出 久美子; 三枝 大輔; 富岡 佳久; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• 炎症反応のマスト細胞活性化におけるリゾホスファチジルセリンの役割

  巻出 久美子; 奥谷 倫世; 井上 飛鳥; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• PLA1型リゾリン脂質産生酵素の受容体活性化機構の解析

  首藤 啓明; 井上 飛鳥; 北村 一; 石黒 純; 有馬 直明; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• 広範なGPCRシグナルを検出する新規測定法-TGFα切断アッセイ-の開発

  石黒 純; 井上 飛鳥; 有馬 直明; 首藤 啓明; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• 胎生期骨形成におけるLPAシグナリングの役割の解明

  板井 恵理子; 有馬 直明; 濱 弘太郎; 井上 飛鳥; 奥平 真一; Chun Jerold; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• リゾ脂質受容体研究の新展開 リゾホスファチジルセリンの産生酵素と受容体

  青木 淳賢; 北村 一; 奥谷 倫世; 佐藤 侑介; 巻出 久美子; 井上 飛鳥

  脂質生化学研究, May 2010

  
• LC-ESI-MS/MSを用いたリゾリン脂質定量系の開発

  井上 飛鳥; 小野 めぐみ; 三枝 大輔; 奥谷 倫世; 奥平 真一; 鈴木 直人; 富岡 佳久; 青木 淳賢

  脂質生化学研究, May 2010

  
• TGFα切断アッセイによるGPCRシグナルの検出

  石黒 純; 井上 飛鳥; 有馬 直明; 東山 繁樹; 青木 淳賢

  脂質生化学研究, May 2010

  
• オートタキシントランスジェニックマウスの解析

  雪浦 弘志; 奥平 真一; 大上 満; 小野 めぐみ; 井上 飛鳥; 濱 弘太郎; 青木 淳賢

  脂質生化学研究, May 2010

  
• LC-ESI-MS-MSを用いたリゾホスファチジルセリンの検出

  奥谷倫世; 井上飛鳥; 巻出久美子; 三枝大輔; 富岡佳久; 青木淳賢; 青木淳賢

  日本薬学会東北支部大会講演要旨集, 2010

  
• コンディショナルノックアウトマウスを用いたオートタキシンの機能解析

  有馬 直明; 大上 満; 奥平 真一; 井上 飛鳥; Moolenaar Wouter; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• リゾホスファチジルセリン受容体P2Y10のリガンド特異性の解析

  北村 一; 巻出 久美子; 奥谷 倫世; 井上 飛鳥; 有馬 直明; 尾谷 優子; 大和田 智彦; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• 膜結合型TGFα切り出しを利用した新規GPCR活性化評価法の開発

  井上 飛鳥; 石黒 純; 有馬 直明; 東山 繁樹; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• TGFα切断アッセイによるGPCRシグナルの検出

  石黒 純; 井上 飛鳥; 有馬 直明; 東山 繁樹; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• 新規リゾホスファチジルセリン受容体の同定

  奥谷 倫世; 北村 一; 井上 飛鳥; 有馬 直明; 尾谷 優子; 巻出 久美子; 大和田 智彦; 青木 淳賢

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• 【情報伝達をつかさどる生理活性物質 脂質メディエーターの機能】 第二世代の生理活性脂質としてのリゾリン脂質

  井上 飛鳥; 青木; 淳賢

  実験医学, Aug. 2009

  
• 模型プロテアーゼ活性化を指標にした新規リゾホスファチジルセリン受容体の同定

  奥谷 倫世; 北村 一; 有馬 直明; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  生化学, Jun. 2009

  
• 体毛形成におけるホスファチジン酸特異的ホスホリパーゼA1αの機能解析

  有馬 直明; 井上 飛鳥; 新井 洋由; 青木 淳賢

  日本薬学会年会要旨集, Mar. 2009

  
• リゾリン脂質の新しい機能 体毛形成におけるリゾホスファチジン酸の機能解明

  井上 飛鳥; 有馬 直明; 新井 洋由; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

  
• ホスファチジン酸特異的ホスホリパーゼA1の体毛形成への関与

  井上 飛鳥; 有馬 直明; 新井 洋由; 青木 淳賢

  脂質生化学研究, May 2008

  
• PS-PLA1とmPA-PLA1αの基質特異性におけるループ構造の関与

  有馬 直明; 井上 飛鳥; 巻出 久美子; 青木 淳賢

  脂質生化学研究, May 2008

  
• リピッドメディエーターの最前線 育毛におけるリゾホスファチジン酸の新規機能

  青木 淳賢; 井上 飛鳥; 新井 洋由

  日本薬学会年会要旨集, Mar. 2008

  
• ホスファチジン酸特異的ホスホリパーゼA1の体毛形成への関与

  井上 飛鳥; 有馬 直明; 新井 洋由; 青木 淳賢

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2007

  
• 【脂質の新たな機能を追う】 リゾリン脂質メディエーターの作用と生理的役割

  巻出 久美子; 奥平; 真一; 井上; 飛鳥; 遠藤; 智子; 田中; 将之; 新井; 洋由; 青木 淳賢

  細胞工学, Oct. 2007

  
• 新規ホスファチジン酸特異的ホスホリパーゼA1の着床促進効果

  井上 飛鳥; 濱 弘太郎; 青木 淳賢; 新井 洋由

  脂質生化学研究, May 2006

  

Awards

• 04 Feb. 2025

  第２１回（令和６年度）日本学士院学術奨励賞
• 14 Apr. 2021

  令和３年度文部科学大臣表彰

External funds: Kakenhi

• G13共役型デザイナーGPCRの開発と遺伝薬理学論の概念実証

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  井上 飛鳥

  From 01 Apr. 2025, To 31 Mar. 2029, Granted

  GPCR;作動薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25H01016/
• 受容体分解の制御機構解明から開拓する分解誘導薬の合理的設計論

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  井上 飛鳥

  From 28 Jun. 2024, To 31 Mar. 2028, Granted

  GPCR;タンパク質分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21281/
• ミトラガイナアルカロイドを基盤とする副作用を示さないオピオイド作動性鎮痛薬の創製

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Chiba University

  石川 勇人

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  オピオイド受容体;ミトラガイナアルカロイド;構造活性相関研究;インドール;バイアス型アゴニスト;パーシャルアゴニスト;鎮痛活性;オピオイド作動薬;アルカロイド;Gバイアス型リガンド;構造シグナル相関研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18174/
• Identification of pharmacologically relevant signaling pathways at opioid receptors

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (II)

  Tohoku University

  Asuka Inoue

  From 23 Aug. 2021, To 31 Mar. 2024, Project Closed

  GPCR;オピオイド;オピオイド受容体;シグナル伝達;計算科学;バイアス

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05113/
• Multi-scale platform for untangling physiological complexity

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (II)

  University of Tsukuba

  Tsuyoshi Saitoh

  From 23 Aug. 2021, To 31 Mar. 2024, Project Closed

  オピオイド受容体;Gタンパク質共役型受容体;シグナル伝達;クライオ電子顕微鏡単粒子解析;神経回路;創薬化学;GPCR;オピオイド;構造生物学;神経科学;作動薬

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-21H05111/
• Structural dynamics of GPCR in cells

  Grant-in-Aid for Scientific Research (S)

  Broad Section G

  The University of Tokyo

  濡木 理

  From 05 Jul. 2021, To 31 Mar. 2026, Granted

  GPCR;生体膜;クライオ電子顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H05037/
• Manipulation of G12/13 signaling and and drug development strategy

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Tohoku University

  井上 飛鳥

  From 05 Apr. 2021, To 31 Mar. 2025, Granted

  GPCR;G12;DREADD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04791/
• A study of novel lysophospholipids and exploration of their targets

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43030:Functional biochemistry-related

  Tokyo Medical and Dental University

  Junya Hasegawa

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  リゾリン脂質;イノシトールリン脂質;GPCR;すい臓がん;リン脂質;質量分析;Gタンパク質共役受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03206/
• Study of drug discovery and biomarker for depression based on glial antidepressant receptor (LPA1)

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52030:Psychiatry-related

  Kumamoto University;Department of Clinical Research, National Hospital Organization Kure Medical Center

  Minoru Takebayashi

  From 01 Apr. 2018, To 31 Mar. 2023, Project Closed

  うつ病;リゾリン脂質代謝;リゾフォスファチジン酸;リゾフォスファチジン酸受容体１;抗うつ薬;創薬;栄養療法;LPA1受容体;バイオマーカー;抗うつ薬受容体;LPA受容体;抗うつ薬創薬;DHA-LPA;うつ病バイオマーカー;リゾホスファチジン酸１受容体;グリア;脂質メディエーター;リゾリン脂質;オートタキシン;リン脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02756/
• Signaling basis of GPCR-acting drugs and their therapeutic mechanisms

  Grant-in-Aid for Scientific Research (C)

  Tohoku University

  Asuka Inoue

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  GPCR;Gタンパク質共役型受容体;バイアスリガンド;シグナル;シグナル伝達;薬学;薬理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08264/
• Understanding lipid-regulated TRP channels and their roles in thermal biology

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Tohoku University

  井上 飛鳥

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  TGFα切断アッセイ;リゾリン脂質;脂質;シグナル伝達;TRPチャネル;生理活性

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01377/
• A role of lysophosphatidic acid signaling in male organ

  Grant-in-Aid for Scientific Research (C)

  Tohoku University

  Inoue Asuka

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  リゾホスファチジン酸;Lysosphatidic acid (LPA);雄性生殖器;雄性生殖;脂質メディエーター;LPA;GPCR;精巣;リゾホスファチジン酸（LPA）;Gタンパク質共役型受容体（GPCR）

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26440043/
• Screening for ligands of G protein-coupled receptors using the newly developed TGFalpha shedding assay

  Grant-in-Aid for Young Scientists (B)

  Tohoku University

  Asuka INOUE

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  Gタンパク質共役型受容体;GPCR;TGFalpha;リゾリン脂質;リゾホスファチジルセリン;CRISPR;HEK293;エクトドメイン切断;TRPチャネル;TGFα;オーファン;P2Y10;GPR174

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790064/
• Lysophosphatidic acid regulates hair follicle development

  Grant-in-Aid for Young Scientists (B)

  Tohoku University

  Asuka INOUE

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  リゾリン脂質;毛包;受容体;GPCR;リゾホスファチジン酸;産生酵素;毛根;TGFα;体毛形成;LPA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790058/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Basic Pharmacodynanic Sciences

  4208, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmacology1

  C335, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Basic Pharmacodynanic Sciences

  3208, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Pharmaceutical Sciences II

  6105, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Pharmaceutical Sciences I

  6104, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Pharmaceutical Sciences III

  6106, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar in Basic Patho-Functional Analysis

  2308, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Fall, Graduate School of Pharmaceutical Sciences, 2

Participation in PhD Defense

• 中鎖脂肪酸受容体GPR84を介した代謝調節機構の解明

  NISHIDA AKARI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  24 Mar. 2025
• バイオ高分子の細胞内取り込みに影響を与える細胞因子に関する研究

  KURIYAMA MASASHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  24 Mar. 2025
• 抗うつ薬および慢性ストレスに対するセロトニン神経の報酬応答性変化に関する研究

  KODA MASASHI, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• 感覚機能の制御における末梢・中枢神経細胞TRPチャネルの役割に関する研究

  TOBORI SHOTA, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• Regulation of daily rest timing via G-protein cAMP signaling in the brain central circadian clock

  TANAKA YOUICHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  24 Mar. 2025

Administration

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  教務委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  将来計画委員会　委員