Basic Information

Faculty

• 医学部
• 国際高等教育院

Email Address

• Email Address

  candeias.marcomarques.8rkyoto-u.ac.jp

ID,URL

• J-Global ID

  201601017485646462

Website(s) (URL(s))

• areap53.com

researchmap URL

• https://researchmap.jp/7000015494

Research

Research Topics, Overview of the research

• Research Topics

  p53; p53 mRNA; p53 isoforms; mRNA functions in cancer pathways

Papers

• Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition

  Ana Marques-Ramos; Marco M. Candeias; Juliane Menezes; Rafaela Lacerda; Margaret Willcocks; Alexandre Teixeira; Nicolas Locker; Luisa Romao

  RNA, Nov. 2017, Peer-reviewed

  
• Cancer-specific mutations in p53 induce the translation of 160p53 promoting tumorigenesis

  Marco M. Candeias; Masatoshi Hagiwara; Michiyuki Matsuda

  EMBO REPORTS, Nov. 2016, Peer-reviewed

  
• Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells

  Yasuhiko Sumitomo; Hiroaki Higashitsuji; Hisako Higashitsuji; Yu Liu; Takanori Fujita; Toshiharu Sakurai; Marco M. Candeias; Katsuhiko Itoh; Tsutomu Chiba; Jun Fujita

  BMC BIOTECHNOLOGY, Oct. 2012, Peer-reviewed

  
• The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

  Madhavsai Gajjar; Marco M. Candeias; Laurence Malbert-Colas; Anne Mazars; Jun Fujita; Vanesa Olivares-Illana; Robin Fahraeus

  CANCER CELL, Jan. 2012, Peer-reviewed

  
• The can and can't dos of p53 RNA

  Marco M. Candeias

  BIOCHIMIE, Nov. 2011, Peer-reviewed

  
• Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47

  Karima Bourougaa; Nadia Naski; Cedric Boularan; Coraline Mlynarczyk; Marco M. Candeias; Stefano Marullo; Robin Fahraeus

  MOLECULAR CELL, Apr. 2010, Peer-reviewed

  
• Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes.

  Bruzzoni-Giovanelli H; Fernandez P; Veiga L; Podgorniak MP; Powell DJ; Candeias MM; Mourah S; Calvo F; Marín M

  Journal of experimental & clinical cancer research : CR, Feb. 2010, Peer-reviewed

  
• p53 and little brother p53/47: linking IRES activities with protein functions

  R. Grover; M. M. Candeias; R. Fahraeus; S. Das

  ONCOGENE, Jul. 2009, Peer-reviewed

  
• The p53 mRNA-Mdm2 interaction.

  Naski N; Gajjar M; Bourougaa K; Malbert-Colas L; Fåhraeus R; Candeias MM

  Cell cycle (Georgetown, Tex.), Jan. 2009, Peer-reviewed

  
• Gly-Ala Repeats Induce Position-and Substrate-specific Regulation of 26 S Proteasome-dependent Partial Processing

  Chrysoula Daskalogianni; Sebastien Apcher; Marco M. Candeias; Nadia Naski; Fabien Calvo; Robin Fahraeus

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2008, Peer-reviewed

  
• p53 mrNA controls p53 activity by managing Mdm2 functions

  Marco M. Candeias; Laurence Malbert-Colas; Darren J. Powell; Chrysoula Daskalogianni; Magda M. Maslon; Nadia Naski; Karima Bourougaa; Fabien Calvo; Robin Fahraeus

  NATURE CELL BIOLOGY, Sep. 2008, Peer-reviewed

  
• Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47.

  Powell DJ; Hrstka R; Candeias M; Bourougaa K; Vojtesek B; Fåhraeus R

  Cell cycle (Georgetown, Tex.), Apr. 2008, Peer-reviewed

  
• The novel platinum(IV) complex LA-12 induces p53 and p53/47 responses that differ from the related drug, cisplatin

  Roman Hrstka; Darren J. Powell; Veronika Kvardova; Eva Roubalova; Karima Bourougaa; Marco M. Candeias; Petr Sova; Frantisek Zak; Robin Fahraeus; Borivoj Vojtesek

  ANTI-CANCER DRUGS, Apr. 2008, Peer-reviewed

  
• Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation

  M. M. Candeias; D. J. Powell; E. Roubalova; S. Apcher; K. Bourougaa; B. Vojtesek; H. Bruzzoni-Giovanelli; R. Fahraeus

  ONCOGENE, Nov. 2006, Peer-reviewed

  

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Biochemistry-E2

  N490, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Medical English

  E001, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Biochemistry-E2

  N490, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Medical English

  E001, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Biochemistry-E2

  N490, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical English

  E001, Fall, Graduate School of Medicine, 2
• From Apr. 2016, To Mar. 2017

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Introduction to Biochemistry-E2

  Fall, 全学共通科目
• From Apr. 2017, To Mar. 2018

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Biochemistry-E2

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Biochemistry-E2

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  ILAS Seminar-E2

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Introduction to Biochemistry-E2

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  ILAS Seminar-E2 :Introduction to Human Genetics and Genetic Disease

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  ILAS Seminar-E2 :Introduction to Stem and iPS Cells

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Introduction to Biochemistry-E2

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Medical English

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  ILAS Seminar-E2 :Introduction to Human Genetics and Genetic Disease

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  ILAS Seminar-E2 :Introduction to Stem and iPS Cells

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Introduction to Biochemistry-E2

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Medical English

  Fall, 医学研究科

Participation in PhD Defenses (other than KU)

• Master

  Cristina Maria Botelho da Rocha Barbosa, University of Lisbon, Portugal, Chief Examiner

  16 Dec. 2013