Basic Information

Email Address

• Email Address

  yanagawa.masataka.5zkyoto-u.ac.jp

Professional Memberships

• THE BIOPHYSICAL SOCIETY OF JAPAN
• 日本薬理学会

Academic Degree

• 24 Mar. 2008

  京都大学修士（理学）
• 23 Mar. 2011

  京都大学博士（理学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院理学研究科博士後期課程生物科学専攻, 修了
• 京都大学, 大学院理学研究科修士課程生物科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 理学部理学科, 卒業

Research History

• From Jul. 2026, To Present

  Kyoto University, Department of Biophysics, Graduate School of Science, Professor
• From Apr. 2025, To Jun. 2026

  Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor
• From Apr. 2023, To Mar. 2025

  Tohoku University, Graduate School of Pharmaceutical Sciences Division of Bio-Pharmaceutical Science, Associate Professor
• From Oct. 2021, To Mar. 2023

  日本学術振興会 卓越研究員候補者
• From Dec. 2020, To Mar. 2023

  JST, さきがけ研究員(専任)

Profile

• Profile

  2026年7月から京都大学大学院理学研究科で、細胞内1分子イメージングを用いたシグナル伝達研究を行っています。

  
  

  京都大学在学中から2013年3月までは、生化学的手法とFRET計測を用いて、代謝型グルタミン酸受容体(mGluR)や視物質ロドプシンの構造・機能相関の解析をしていました。

  
  

  2013年4月から理化学研究所佐甲細胞情報研究室で細胞内1分子イメージングに基づく薬効薬理評価系の開発を行いました。

  
  

  2024年4月から2025年3月までは東北大学大学院薬学研究科・2025年4月から2026年6月までは京都大学大学院薬学研究科で1分子計測・生化学を用いたシグナル伝達研究・教育に従事していました。

  
  

  細胞内シグナル伝達の空間的制御メカニズム・動物の進化におけるGPCRの多様性獲得の過程に興味があります。

ID,URL

• J-Global ID

  201801010828430479

• Researcher number

  70609792

researchmap URL

• https://researchmap.jp/masataka_yanagawa

Research

Research Interests

• 薬理学
• Biophysics
• Biochemistry
• Signal transduction
• Single-molecule imaging
• GPCR

Research Areas

• Life sciences, Applied biochemistry
• Life sciences, Functional biochemistry
• Life sciences, Pharmacology
• Life sciences, Biophysics

Papers

• 

  A practical guide to multicolor live-cell single-molecule imaging

  Toshiki Yoda; Ryosuke Sugioka; Asuka Inoue; Masataka Yanagawa

  Aug. 2026, Last author, Corresponding author

  
• 

  A luminescent calcium biosensor enabling endpoint measurement of GPCR-mediated calcium signaling

  Kosuke Doi; Ryoji Kise; Kota Shimizume; Masataka Yanagawa; Asuka Inoue

  Communications Biology, 29 Mar. 2026, Peer-reviewed

  Access this paper :

  
• 

  Re-evaluating Gα protein–response element specificity in GPCR signaling

  Ayaki Saito; Ryoji Kise; So Yamaguchi; Masataka Yanagawa; Asuka Inoue

  Communications Biology, 23 Jan. 2026, Peer-reviewed

  Access this paper :

  
• Single-molecule behavior and cell-growth regulation in human RTKs

  Mitsuhiro Abe; Masataka Yanagawa; Yotaro Koizumi; Ryoji Kise; Asuka Inoue; Yasushi Sako

  30 Dec. 2025, Lead author

  
• 

  Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation

  Peng Zhou; Taka A. Tsunoyama; Rinshi S. Kasai; Koichiro M. Hirosawa; Ziya Kalay; Amine Aladag; Takahiro K. Fujiwara; Tatsushi Yokoyama; Masayuki Sakamoto; Ryoji Kise; Masataka Yanagawa; Asuka Inoue; Simone Pigolotti; Akihiro Kusumi

  Nature Communications, 07 Nov. 2025, Peer-reviewed

  Access this paper :

  
• 

  Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P2 binding

  Ritsuki Kuramoto; Tatsuya Ikuta; Carlo Marion C. Carino; Kouki Kawakami; Miisha Kushiro; Chihiro Watanabe; Yasunori Uchida; Mitsuhiro Abe; Yasushi Sako; Tomohiko Taguchi; Masataka Yanagawa; Asuka Inoue

  Nature Chemical Biology, 06 Aug. 2025, Peer-reviewed

  Access this paper :

  
• 

  Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R

  Fumiya K. Sano; Kota Shimizume; Kazuhiro Kobayashi; Toshikuni Awazu; Kouki Kawakami; Hiroaki Akasaka; Takaaki A. Kobayashi; Tatsuki Tanaka; Hiroyuki H. Okamoto; Hisato Hirano; Tsukasa Kusakizako; Wataru Shihoya; Yoshiaki Kise; Yuzuru Itoh; Ryuichiro Ishitani; Yasushi Okada; Yasushi Sako; Masataka Yanagawa; Asuka Inoue; Osamu Nureki

  Nature Chemical Biology, 26 Jun. 2025, Peer-reviewed, Corresponding author

  Access this paper :

  
• 

  Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy

  Mitsuhiro Abe; Masataka Yanagawa; Michio Hiroshima; Toshihide Kobayashi; Yasushi Sako

  eLife, 08 Nov. 2024, Peer-reviewed

  
• 

  Signal profiles and spatial regulation of β-arrestin recruitment through Gβ5 and GRK3 at the μ-opioid receptor

  Carlo Marion C. Carino; Suzune Hiratsuka; Ryoji Kise; Gaku Nakamura; Kouki Kawakami; Masataka Yanagawa; Asuka Inoue

  European Journal of Pharmacology, Nov. 2024, Peer-reviewed

  
• 

  Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide

  Toshiki Yoda; Yasushi Sako; Asuka Inoue; Masataka Yanagawa

  Biophysics and Physicobiology, Sep. 2024, Peer-reviewed, Last author, Corresponding author

  Access this paper :

  
• 

  Convergent mechanism underlying the acquisition of vertebrate scotopic vision

  Keiichi Kojima; Masataka Yanagawa; Yasushi Imamoto; Yumiko Yamano; Akimori Wada; Yoshinori Shichida; Takahiro Yamashita

  Journal of Biological Chemistry, Mar. 2024, Peer-reviewed

  Access this paper :

  
• 

  TRPV4-dependent Ca2+ influx determines cholesterol dynamics at the plasma membrane

  Yutaro Kuwashima; Masataka Yanagawa; Masashi Maekawa; Mitsuhiro Abe; Yasushi Sako; Makoto Arita

  Biophysical Journal, Mar. 2024, Peer-reviewed

  
• 

  Multi-dimensional condensation of intracellular biomolecules

  Masataka Yanagawa; Shunsuke F Shimobayashi

  The Journal of Biochemistry, 22 Nov. 2023, Peer-reviewed, Lead author, Corresponding author

  
• 

  Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids

  Ryo Maeda; Hiroko Tamagaki-Asahina; Takeshi Sato; Masataka Yanagawa; Yasushi Sako

  Journal of Cell Science, 01 Aug. 2022, Peer-reviewed

  
• 

  Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

  Kouki Kawakami; Masataka Yanagawa; Suzune Hiratsuka; Misaki Yoshida; Yuki Ono; Michio Hiroshima; Masahiro Ueda; Junken Aoki; Yasushi Sako; Asuka Inoue

  Nature Communications, Jan. 2022, Peer-reviewed, Lead author

  
• 

  PMP2/FABP8 induces PI(4,5)P2-dependent transbilayer reorganization of sphingomyelin in the plasma membrane

  Mitsuhiro Abe; Asami Makino; Motohide Murate; Françoise Hullin-Matsuda; Masataka Yanagawa; Yasushi Sako; Toshihide Kobayashi

  Cell Reports, Nov. 2021, Peer-reviewed

  
• 

  Evolutionary adaptation of visual pigments in geckos for their photic environment

  Keiichi Kojima; Yuki Matsutani; Masataka Yanagawa; Yasushi Imamoto; Yumiko Yamano; Akimori Wada; Yoshinori Shichida; Takahiro Yamashita

  Science Advances, Oct. 2021, Peer-reviewed

  Access this paper :

  
• 

  Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells

  Yutaro Kuwashima; Masataka Yanagawa; Mitsuhiro Abe; Michio Hiroshima; Masahiro Ueda; Makoto Arita; Yasushi Sako

  International Journal of Molecular Sciences, 06 Aug. 2021, Peer-reviewed, Invited, Corresponding author

  
• DNA‐Based Synthetic Growth Factor Surrogates with Fine‐Tuned Agonism

  Momoko Akiyama; Ryosuke Ueki; Masataka Yanagawa; Mitsuhiro Abe; Michio Hiroshima; Yasushi Sako; Shinsuke Sando

  Angewandte Chemie International Edition, 29 Jul. 2021, Peer-reviewed

  
• Workflows of the Single-Molecule Imaging Analysis in Living Cells: Tutorial Guidance to the Measurement of the Drug Effects on a GPCR

  Masataka Yanagawa; Yasushi Sako

  Methods in Molecular Biology, May 2021, Invited, Lead author, Corresponding author

  
• Resolvin E3 attenuates allergic airway inflammation via the interleukin-23-interleukin-17A pathway.

  Makiko Sato; Haruka Aoki-Saito; Hayato Fukuda; Hiroyuki Ikeda; Yasuhiko Koga; Masakiyo Yatomi; Hiroaki Tsurumaki; Toshitaka Maeno; Tsugumichi Saito; Takashi Nakakura; Tetsuya Mori; Masataka Yanagawa; Mitsuhiro Abe; Yasushi Sako; Kunio Dobashi; Tamotsu Ishizuka; Masanobu Yamada; Satoshi Shuto; Takeshi Hisada

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Nov. 2019, Peer-reviewed

  
• 

  Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates

  Keita Sato; Takahiro Yamashita; Keiichi Kojima; Kazumi Sakai; Yuki Matsutani; Masataka Yanagawa; Yumiko Yamano; Akimori Wada; Naoyuki Iwabe; Hideyo Ohuchi; Yoshinori Shichida

  Communications Biology, Oct. 2018, Peer-reviewed

  Access this paper :

  
• Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors.

  Masataka Yanagawa; Michio Hiroshima; Yuichi Togashi; Mitsuhiro Abe; Takahiro Yamashita; Yoshinori Shichida; Masayuki Murata; Masahiro Ueda; Yasushi Sako

  Science signaling, 18 Sep. 2018, Peer-reviewed

  
• 

  Lipid-Protein Interplay in Dimerization of Juxtamembrane Domains of Epidermal Growth Factor Receptor

  Ryo Maeda; Takeshi Sato; Kenji Okamoto; Masataka Yanagawa; Yasushi Sako

  Biophysical Journal, 27 Feb. 2018, Peer-reviewed

  
• 

  Adaptation of cone pigments found in green rods for scotopic vision through a single amino acid mutation

  Keiichi Kojima; Yuki Matsutani; Takahiro Yamashita; Masataka Yanagawa; Yasushi Imamoto; Yumiko Yamano; Akimori Wada; Osamu Hisatomi; Kanto Nishikawa; Keisuke Sakurai; Yoshinori Shichida

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2017, Peer-reviewed

  
• 

  Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral.

  Yoshizawa R; Umeki N; Yanagawa M; Murata M; Sako Y

  Biophysics and physicobiology, 2017, Peer-reviewed

  
• 

  Origin of the low thermal isomerization rate of rhodopsin chromophore

  Masataka Yanagawa; Keiichi Kojima; Takahiro Yamashita; Yasushi Imamoto; Take Matsuyama; Koji Nakanishi; Yumiko Yamano; Akimori Wada; Yasushi Sako; Yoshinori Shichida

  SCIENTIFIC REPORTS, Jun. 2015, Peer-reviewed

  Access this paper :

  
• 

  Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  Journal of Biological Chemistry, 05 Apr. 2013, Peer-reviewed

  
• 

  Comparative Fluorescence Resonance Energy Transfer Analysis of Metabotropic Glutamate Receptors IMPLICATIONS ABOUT THE DIMERIC ARRANGEMENT AND REARRANGEMENT UPON LIGAND BINDINGS

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2011, Peer-reviewed, Lead author

  
• 

  Activation Switch in the Transmembrane Domain of Metabotropic Glutamate Receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  MOLECULAR PHARMACOLOGY, Jul. 2009, Peer-reviewed

  

Misc.

• 

  膜受容体の細胞内1分子蛍光顕微鏡観察

  柳川 正隆

  顕微鏡, Jan. 2025, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Molecular mechanism underlying color discrimination ability of frogs and geckos in the dark

  Keiichi KOJIMA; Masataka YANAGAWA; Takahiro YAMASHITA

  Hikaku seiri seikagaku(Comparative Physiology and Biochemistry), 07 Dec. 2022

  
• 

  Single-molecule Imaging of GPCRs: An Application to the Drug Evaluation and Pharmacology

  Masataka YANAGAWA; Yasushi SAKO

  Seibutsu Butsuri, Nov. 2021, Peer-reviewed, Invited, Lead author

  
• GPCRの細胞内1分子イメージング

  柳川 正隆; 佐甲 靖志

  細胞, Apr. 2021, Invited, Lead author, Corresponding author

  
• 樹状細胞に対する炎症収束性メディエーターResolvinE3の作用の検討

  佐藤 真季子; 齋藤 悠; 鶴巻 寛朗; 矢冨 正清; 古賀 康彦; 砂長 則明; 前野 敏孝; 石塚 全; 柳川 正隆; 佐甲 靖志; 阿部 充宏; 土橋 邦生; 周東 智; 久田 剛志

  アレルギー, Oct. 2020

  
• 細胞膜受容体の1分子イメージング

  柳川 正隆; 佐甲 靖志

  生体の科学, Oct. 2017, Invited

  
• Gタンパク質共役型受容体の進化

  柳川 正隆; 七田 芳則

  生体の科学, Aug. 2013, Invited

  
• 

  Dimerization of G protein-coupled receptors: Molecular mechanism of the interprotomer communication

  Masataka Yanagawa; Yoshinori Shichida

  Seikagaku, 2011, Invited

  

Presentations

• 細胞内の分子に個性はあるか：1分子で見る薬のしくみ

  柳川 正隆

  第35回 日本バイオイメージング学会, 03 Oct. 2026, Invited

  
• Unveiling receptor dynamics with single-molecule imaging

  Masataka Yanagawa

  GIST Workshop: Bridging GPCR Signaling and Neural Dynamics, 10 Apr. 2026, Invited

  
• Unveiling receptor dynamics with single-molecule imaging

  Masataka Yanagawa

  SiMBio2026, 21 Jan. 2026, Invited

  
• GPCR signaling regulation via membrane domains

  Masataka Yanagawa

  The 98th Annual Meeting of the JBS, 04 Nov. 2025, Invited

  
• Unveiling receptor dynamics with single-molecule high-content analysis

  Masataka Yanagawa

  IUPAB 2024, 26 Jun. 2024, Invited

  
• GPCR研究における 細胞内1分子イメージングの使いどころ

  柳川 正隆; 佐甲 靖志; 井上 飛鳥

  第18回 GPCR研究会, 21 May 2024

  
• 膜受容体-脂質間相互作用の 1分子イメージング

  柳川 正隆

  第3回 京都薬科大学シナジー共同研究講演会, 22 Mar. 2024, Invited

  
• Single-molecule imaging analysis of GPCR signalosome

  Masataka Yanagawa

  OIST-JST Joint Meeting, 19 Jan. 2024

  
• Co-regulation of GPCR-mediated ERK signaling by G protein and β-arrestin

  Masataka Yanagawa

  The 61st Annual Meeting of the Biophysical Society of Japan, 15 Nov. 2023, Invited

  
• Single-molecule imaging analysis of G protein-coupled receptor signalosome

  Masataka Yanagawa

  2023 East Asian Single-Molecule Biophysics Symposium, 22 Sep. 2023, Invited

  
• 細胞内1 分子イメージングに基づく膜受容体の薬効薬理解析

  柳川 正隆

  第8回 医薬品開発研究センターシンポジウム, 07 Aug. 2023, Invited

  
• GPCRの細胞内1分子イメージング

  柳川 正隆

  シンポジウム「光といのち」, 25 Mar. 2023, Invited

  
• Single-molecule imaging analysis of G protein-coupled receptor signalosome

  Masataka Yanagawa

  NAIST Workshop, 16 Feb. 2023, Invited

  
• Single-molecule imaging analysis of G protein-coupled receptor signalosome

  Masataka Yanagawa

  2022 Chinese Biophysics Congress, 03 Dec. 2022, Invited

  
• Single-molecule imaging analysis of G protein-coupled receptor signalosome

  Masataka Yanagawa

  MBSJ2022, 01 Dec. 2022, Invited

  
• Workflows of triple-color single-molecule localization microscopy analysis to assess co-clustering of membrane receptors and lipid domains

  Masataka Yanagawa; Mitsuhiro Abe; Yasushi Sako

  第60回日本生物物理学会年会, 30 Sep. 2022

  
• CMOS カメラを用いた次世代ハイコンテント解析システムへの展望

  柳川 正隆

  第60回日本生物物理学会年会 浜松ホトニクス株式会社BP セミナー, 28 Sep. 2022, Invited

  
• Toward Next Generation High-Content Analysis with Automated Multicolor Single-Molecule Imaging in Living Cells

  Masataka Yanagawa

  The 95th Annual Meeting of the Japanese Pharmacological Society, 09 Mar. 2022, Invited

  
• Comparative analysis of single-molecule dynamics of TRPV1 and TRPV4 channels in living cells

  Masataka Yanagawa; Yutaro Kuwashima; Mitsuhiro Abe; Michio Hiroshima; Masahiro Ueda; Makoto Arita; Yasushi Sako

  The 59th Annual Meeting of The Biophysical Society of Japan, 26 Nov. 2021, Invited

  
• 膜受容体の細胞内1分子計測を 薬効薬理評価に応用する

  柳川 正隆

  第13回光塾, 28 Sep. 2021, Invited

  
• GPCRの細胞膜中の拡散動態計測を薬効薬理評価に応用する

  柳川 正隆

  機能物性研究セミナー, 11 Jul. 2021, Invited

  
• GPCRの細胞内1分子計測に基づく薬効薬理評価

  柳川 正隆

  第2回 マルチNGSオミクス解析研究会, 23 Mar. 2021, Invited

  
• Single-molecule imaging of GPCR signalosome in living cell

  Masataka Yanagawa

  第94回 日本薬理学会年会, 10 Mar. 2021, Invited

  
• 脂質膜ドメイン間の分配に基づく 膜受容体のシグナル伝達制御

  柳川正隆; 桑島佑太朗; 有田誠; 佐甲靖志

  生理学研究所 研究会 「イオンチャネルと生体膜のダイナミズム： 構造生物学の先にあるもの」, 06 Oct. 2020

  
• Single-molecule imaging of GPCR signalosome in living cell membrane

  Masataka Yanagawa

  The 58th Annual Meeting of The Biophysical Society of Japan, 17 Sep. 2020, Invited

  
• Gタンパク質依存的なβアレスチン制御メカニズムの発見と解析

  川上耕季; 柳川正隆; 平塚寿々音; SHUKLA Arun K.; 佐甲靖志; 青木淳賢; 青木淳賢; 青木淳賢; 井上飛鳥; 井上飛鳥; 井上飛鳥

  日本生化学会大会(Web), 2020

  
• GPCRの細胞内1分子動態から薬効を読み解く

  柳川 正隆

  定量生物学の会 北海道キャラバン 2019, 07 Nov. 2019, Invited

  
• 膜受容体の細胞内1分子動態から薬効を読み解く

  柳川 正隆

  生理学研究所 研究会 「イオンチャネルと生体膜のダイナミズム： 構造生物学の先にあるもの」, 01 Oct. 2019

  
• Estimation of multiple drug effects on GPCR based on the single-molecule diffusion dynamics

  Masataka Yanagawa

  第57回 日本生物物理学会年会, 24 Sep. 2019, Invited

  
• GPCRの1分子動態から薬効を読み解く

  柳川 正隆

  第92回 日本生化学会大会, 18 Sep. 2019, Invited

  
• Toward single-molecule imaging-based pharmacology of G protein-coupled receptors

  Masataka Yanagawa

  第56回日本生物物理学会年会, 17 Sep. 2018, Invited

  
• 1分子拡散動態を指標にしたGPCRの活性評価

  柳川 正隆

  蛋白研セミナー：生体膜上の生物化学2018, Mar. 2018, Invited

  
• ピノプシンは薄明視を担う視物質として進化してきた光受容タンパク質である

  佐藤恵太; 山下高廣; 小島慧一; 松谷優樹; 酒井佳寿美; 柳川正隆; 山野由美子; 和田昭盛; 岩部直之; 大内淑代; 七田芳則; 七田芳則

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• 細胞内1分子イメージングによるGPCRの活性推定

  柳川 正隆

  第34回 理研イブニングセミナー, 08 Nov. 2017, Invited

  
• 1分子拡散動態を指標にしたGPCRの活性評価

  柳川 正隆

  研究会「理論と実験」2017, Oct. 2017

  
• Single-molecule imaging-based estimation of GPCR activity

  Masataka Yanagawa; Michio Hiroshima; Yuichi Togashi; Takahiro Yamashita; Yoshinori Shichida; Masayuki Murata; Masahiro Ueda; Yasushi Sako

  日本生物物理学会第55回年会, Sep. 2017

  
• 1分子イメージングによるGPCRの活性評価システム

  柳川 正隆

  DSANJ Biz Meeting, Aug. 2017, Invited

  
• Single-molecule pharmacology of a G protein-coupled receptor

  Masataka Yanagawa

  International Symposium on Biophysics of Rhodopsins, May 2017, Invited

  
• Single-molecule pharmacology of a GPCR

  Masataka Yanagawa

  Behavior & Logic of Cellular Systems IX, Riken Symposium, Apr. 2017

  
• Single-molecule pharmacology of a GPCR

  Masataka Yanagawa

  University of Strasbourg-RIKEN Workshop on Membrane Lipidology, Mar. 2017

  
• Comparative analysis of diffusion-function relationship of G protein-coupled receptors on the living cell surface

  Masataka Yanagawa; Michio Hiroshima; Yuichi Togashi; Takahiro Yamashita; Yoshinori Shichida; Masayuki Murata; Masahiro Ueda; Yasushi Sako

  日本生物物理学会第54回年会, Nov. 2016

  
• 1分子動態を指標としたClass C GPCRの活性推定

  柳川正隆; 廣島通夫; 冨樫祐一; 山下高廣; 七田芳則; 村田昌之; 上田昌宏; 佐甲靖志

  第13回GPCR研究会, May 2016

  
• Ras‐RalGDS相互作用の1分子蛍光イメージング

  梅木伸久; 吉澤亮; 中村由樹; 稲葉岳彦; 前田亮; 柳川正隆; 佐甲靖志

  日本生化学会大会(Web), Dec. 2015, (公社)日本生化学会

  
• 生細胞膜上の1分子拡散動態に基づくGPCRの活性推定

  柳川 正隆; 廣島通夫; 山下 高廣; 七田 芳則; 佐甲靖志

  研究会「理論と実験」2015, Oct. 2015

  
• Single-molecule imaging of GPCR oligomerization followed by internalization

  Masataka Yanagawa; Michio Hiroshima; Takahiro Yamashita; Yoshinori Shichida; Yasushi Sako

  日本生物物理学会第53回年会, Sep. 2015, Invited

  
• 全反射蛍光顕微鏡による代謝型グルタミン酸受容体の 1 分子動態解析

  柳川 正隆; 廣島通夫; 山下 高廣; 七田 芳則; 佐甲靖志

  生理研研究会「膜システムの機能的・構造的統合」, Aug. 2015

  
• 1分子イメージングでみる代謝型グルタミン酸受容体の高次多量体形成と内在化

  柳川 正隆; 廣島通夫; 山下 高廣; 七田 芳則; 佐甲靖志

  第12回GPCR研究会, May 2015

  
• １分子イメージングでみる代謝型グルタミン酸受容体の高次多量体化とエンドサイトーシス

  柳川 正隆; 廣島通夫; 山下 高廣; 七田 芳則; 佐甲靖志

  理研シンポジウム「細胞システムの動態と論理VII」, Apr. 2015

  
• 1分子蛍光イメージングで見る生細胞膜中で集まるGPCR

  柳川 正隆

  第87回日本生化学会大会, Oct. 2014, Invited

  
• Single-molecule imaging analysis of higher-order oligomerization and internalization of metabotropic glutamate receptor

  Masataka Yanagawa; Michio Hiroshima; Takahiro Yamashita; Yoshinori Shichida; Yasushi Sako

  日本生物物理学会第52回年会, Sep. 2014

  
• 1分子イメージングによる代謝型グルタミン酸受容体の細胞内動態解析

  柳川正隆; 廣島通夫; 山下高廣; 七田芳則; 佐甲靖志

  理研シンポジウム「細胞システムの動態と論理VI」, Apr. 2014

  
• Lateral diffusion of metabotropic glutamate receptor observed in single-molecules on the living cell surface

  柳川正隆; 廣島通夫; 山下高廣; 七田芳則; 佐甲靖志

  日本生物物理学会第51回年会, Oct. 2013

  
• GPCR の多量体化による機能調節メカニズムの解明に向けて

  柳川 正隆; 廣島通夫; 山下 高廣; 七田 芳則; 佐甲靖志

  研究会「理論と実験」2013, Oct. 2013

  
• Dimeric arrangement of metabotropic glutamate receptor and its synergistic rearrangement upon the binding of two glutamates

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  日本生物物理学会第49回年会, Sep. 2011

  
• Dimeric arrangement of metabotropic glutamate receptor and its synergistic rearrangement upon the binding of two glutamates

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  The 5th international Symposium of the Biodiversity & Evolution Global COE project, Jul. 2011

  
• Key amino acid residue linking the dimeric rearrangement to the G protein activation ability of metabotropic glutamate receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  日本生物物理学会第48回年会, Sep. 2010

  
• Comparative analyses of ligand-induced dimeric rearrangements of metabotropic glutamate receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  日本生物物理学会第47回年会, Oct. 2009

  
• An activation switch in the transmembrane domain of metabotropic glutamate receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  15th International Congress on Photobiology,, Jun. 2009

  
• A dimer interface in the transmembrane domain responsible for the activation process of metabotropic glutamate receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  日本生物物理学会第46回年会, Dec. 2008

  
• Identification of a novel conformational switch in the transmembrane domain of metabotropic glutamate receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  The 2nd International Symposium of the Biodiversity & Evolution Global COE project, Nov. 2008

  
• Amino acid interactions in the transmembrane domain responsible for the activation process of metabotropic glutamate receptor

  Masataka Yanagawa; Takahiro Yamashita; Yoshinori Shichida

  日本生物物理学会第45回年会, Dec. 2007

  
• Identification of amino acid residues responsible for the helical movement of metabotropic glutamate receptor in the activation process

  Masataka Yanagawa; Takahiro Yamashita; Akihisa Terakita; Yoshinori Shichida

  Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, Nov. 2006

  

Industrial Property Rights

• 特願2019-152455, Gタンパク質共役型受容体(GPCR)の解析方法

  柳川正隆; 廣島通夫; 阿部 充宏; 上田昌宏; 佐甲靖志

  
• 特願15/957406, METHOD FOR EVALUATING ACTIVITY OF G PROTEIN-COUPLED RECEPTOR (GPCR)

  Masataka Yanagawa; Yasushi Sako; Michio Hiroshima; Masato Yasui; Masahiro Ueda; Yuichi Togashi

  
• 特願2017-084803, Gタンパク質共役型受容体(GPCR)の活性評価方法

  柳川 正隆; 佐甲 靖志; 廣島 通夫; 安井 真人; 上田 昌宏; 冨樫 祐一

  

Awards

• 23 Mar. 2022

  桜舞賞（理化学研究所）
• 15 May 2009

  第２１回加藤記念国際交流助成(加藤記念バイオサイエンス研究振興財団)

External funds: Kakenhi

• 「1分子創薬」を加速する細胞内高速1分子イメージングの基盤技術開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  柳川 正隆

  From 26 Jun. 2026, To 31 Mar. 2028, Granted

  1分子イメージング;超解像顕微鏡;GPCR;シグナル伝達;蛍光タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K23146/
• 膜界面における分子光操作と数理的ダイナミクス解析

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  下林 俊典

  From 01 Apr. 2025, To 31 Mar. 2030, Granted

  液液相分離

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25H01328/
• 細胞内1分子計測に基づく膜受容体による形質膜リモデリングの解析

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43040:Biophysics-related

  Tohoku University

  柳川 正隆

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  GPCR;EGFR;TRPV4;1分子計測;超解像計測;脂質;PIP2;コレステロール;TRPチャネル;超解像イメージング;1分子イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01982/
• 細胞内で区画化されたGPCRシグナル伝達を司るメゾ複合体の解明

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University;Tohoku University

  柳川 正隆

  From 01 Apr. 2024, To 31 Mar. 2026, Granted

  細胞内1分子計測;シグナル伝達;GPCR;アレスチン;エンドソーム;顕微鏡;バイオイメージング;1分子計測;エンドソームシグナル;超解像計測;1分子イメージング;細胞内シグナル伝達;膜輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24H01266/
• Single-molecule imaging-based GPCRome analysis

  Grant-in-Aid for Scientific Research (C)

  Basic Section 37030:Chemical biology-related

  Institute of Physical and Chemical Research

  Masataka Yanagawa

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  GPCR;1分子イメージング;細胞内シグナル伝達;アレスチン;エンドサイトーシス;ERKシグナル;拡散機能相関;Raf;ERK;1分子薬理学;ハイコンテント解析;実験自動化;1分子計測;シグナルバイアス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K05760/
• Elucidation of the mechanisms underlying the execution of necroptosis

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49030:Experimental pathology-related

  Toho University

  Hiroyasu NAKANO

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  ネクロプトーシス;１分子イメージング;全反射顕微鏡;DAMPs;FRET;SMART;シスプラチン;in vivoイメージング;トランスジェニックマウス;HMGB1;1分子イメージング;イメージング;一分子イメージング;多光子顕微鏡;アポトーシス;MLKL;cFLIPL;MIB2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03475/
• Comparative analysis of the single-molecule diffusion-function relationships of GPCR

  Grant-in-Aid for Young Scientists (B)

  Institute of Physical and Chemical Research

  Masataka Yanagawa

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  GPCR;1分子イメージング;拡散機能相関;代謝型グルタミン酸受容体;拡散・機能相関;1分子薬理学;全反射蛍光顕微鏡;拡散動態;シグナル伝達;拡散係数;生物物理学;薬理学;生化学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18533/
• Single-molecule imaging analysis of oligomerization of GPCRs

  Grant-in-Aid for Young Scientists (B)

  Institute of Physical and Chemical Research

  Masataka Yanagawa

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  GPCR;代謝型グルタミン酸受容体;セロトニン受容体;1分子イメージング;多量体化;FRET;生物物理学;薬理学;生化学;統合失調症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26840055/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmacology 3 (Central Nervous System Pharmacology)

  A307, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pre-Training for Clinical Clerkship

  E354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmacology3

  C337, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pre-Training for Clinical Clerkship

  B354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3

Academic, Social Contribution

Committee Memberships

• From Jan. 2026, To Present

  会誌副編集委員長, 日本生物物理学会
• From Apr. 2024, To Present

  第11期 バイオ単分子研究会委員, ATFーセイコーインスツル新世代研究財団
• From 2021, To Present

  分野別専門委員(受容体), 日本生物物理学会
• From Jan. 2025, To Dec. 2025

  会誌編集委員, 日本生物物理学会
• From Apr. 2021, To Mar. 2024

  第10期バイオ単分子研究会委員, ATI新世代研究所
• From 2017, To 2017

  分野別専門委員(受容体), 日本生物物理学会

Academic Contribution

• IUPAB 2024, Symposium 15, Single Molecule Biophysics with Advanced Techniques

  Panel moderator

  Masataka Yanagawa, From 26 Jun. 2024, To 26 Jun. 2024

  
• 2022 Chinese Biophysics Congress, Session-Unconventional Membrane Trafficking, Innovative Thinking

  Panel moderator

  Anbing Shi, Masataka Yanagawa, From 03 Dec. 2022, To 03 Dec. 2022

  
• The 45th Annual Meeting of the Molecular Biology Society of Japan, Workshop: Synergetic liquid-liquid phase separation in and on cell membranes

  Panel moderator

  Shunsuke Shimobayashi, Masataka Yanagawa, From 01 Dec. 2022, To 01 Dec. 2022