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Kobayashi, Akiko
Graduate School of Medicine Program-Specific Associate Professor
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Last Updated :2025/05/27
Basic Information
Faculty
Academic Degree
Academic Resume (Graduate Schools)
Research History
- From Apr. 2023, To PresentKyoto University, Graduate School of Medicine, Associate Professor
- From Apr. 2015, To Mar. 2023Kyoto University, Graduate School of Medicine, Assistant Professor
- From Oct. 2012, To Mar. 2015Kyoto University, Graduate School of Medicine, Assistant Professor
- From Aug. 2007, To Sep. 2012Cold Spring Harbor Laboratory, Postodoctoral Fellow
- From Apr. 2006, To Jul. 2007Tsukuba University, Graduate School of Medicine, Postodoctoral Fellow
- From Apr. 2002, To Mar. 2006University of Tokyo, Graduate School of Pharmaceutical Sciences, Graduate Student
- From Apr. 2000, To Mar. 2002University of Tokyo, Graduate School of Pharmaceutical Sciences, Graduate Student
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ORCID ID
J-Global ID
Website(s) (URL(s))
researchmap URL
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Last Updated :2025/05/27
Research
Research Topics, Overview of the research
Research Topics
Understanding the molecular mechanism underlying psychiatric/developmental disorders and screening chemical seeds for cure.Overview of the research
The overall goal of my research is to further understand the molecular mechanism underlying psychiatric/neurodevelopmental disorders, hoping to utilize the acquired findings to develop drugs to rescue the disease-related deficits.
Research Areas
Papers
- Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathwayAkiko Nakano-Kobayashi; Andres Canela; Toru Yoshihara; Masatoshi HagiwaraProceedings of the National Academy of Sciences, 15 Aug. 2023
- Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammationA. Nakano-Kobayashi; A. Fukumoto; A. Morizane; D. T. Nguyen; T. M. Le; K. Hashida; T. Hosoya; R. Takahashi; J. Takahashi; O. Hori; M. HagiwaraScience Advances, Nov. 2020, Peer-reviewed
- DYRK1A and cognition: A lifelong relationship.Arbones ML; Thomazeau A; Nakano-Kobayashi A; Hagiwara M; Delabar JMPharmacology & therapeutics, Sep. 2018, Peer-reviewed
- RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomiaKenji Ohe; Mayumi Yoshida; Akiko Nakano-Kobayashi; Motoyasu Hosokawa; Yukiya Sako; Maki Sakuma; Yukiko Okuno; Tomomi Usui; Kensuke Ninomiya; Takayuki Nojima; Naoyuki Kataoka; Masatoshi HagiwaraRNA, Sep. 2017, Peer-reviewed
- Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome miceAkiko Nakano-Kobayashi; Tomonari Awaya; Isao Kii; Yuto Sumida; Yukiko Okuno; Suguru Yoshida; Tomoe Sumida; Haruhisa Inoue; Takamitsu Hosoya; Masatoshi HagiwaraPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2017, Peer-reviewed
- The X-linked Mental Retardation Protein OPHN1 Interacts with Homer1b/c to Control Spine Endocytic Zone Positioning and Expression of Synaptic PotentiationAkiko Nakano-Kobayashi; Yilin Tai; Nael Nadif Kasri; Linda Van AelstJOURNAL OF NEUROSCIENCE, Jun. 2014, Peer-reviewed
- Rapid Synthesis of the X-Linked Mental Retardation Protein OPHN1 Mediates mGluR-Dependent LTD through Interaction with the Endocytic MachineryNael Nadif Kasri; Akiko Nakano-Kobayashi; Linda Van AelstNEURON, Oct. 2011, Peer-reviewed
- The Rho-Linked Mental Retardation Protein OPHN1 Controls Synaptic Vesicle Endocytosis via Endophilin A1Akiko Nakano-Kobayashi; Nael Nadif Kasri; Sarah E. Newey; Linda Van AelstCURRENT BIOLOGY, Jul. 2009, Peer-reviewed
- The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptorsNael Nadif Kasri; Akiko Nakano-Kobayashi; Roberto Malinow; Bo Li; Linda Van AelstGENES & DEVELOPMENT, Jun. 2009, Peer-reviewed
- Novel activation mechanism and physiological function of PIP5K gamma 661Yasunori Kanaho; Akiko Nakano-Kobayashi; Takeaki YokozekiADVANCES IN ENZYME REGULATION, VOL 48, 2008, Peer-reviewed
- The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4,5P2Yasunori Kanaho; Akiko Kobayashi-Nakano; Takeaki YokozekiBiological and Pharmaceutical Bulletin, Sep. 2007, Peer-reviewed
- Role of activation of PIP5K gamma 661 by AP-2 complex in synaptic vesicle endocytosisAkiko Nakano-Kobayashi; Masakazu Yamazaki; Takamitsu Unoki; Tsunaki Hongu; Chie Murata; Ryo Taguchi; Toshiaki Katada; Michael A. Frohman; Takeaki Yokozeki; Yasunori KanahoEMBO JOURNAL, Feb. 2007, Peer-reviewed
Misc.
- 神経新生促進によるダウン症モデルにおける脳発達障害の是正小林 亜希子; 粟屋 智就; 喜井 勲; 隅田 有人; 奥野 友紀子; 和根崎 圭子; 吉田 優; 隅田 ともえ; 井上 治久; 細谷 孝充; 萩原 正敏生命科学系学会合同年次大会, Dec. 2017
- 神経新生促進によるダウン症モデルにおける脳発達障害の是正小林亜希子; 粟屋智就; 喜井勲; 隅田有人; 奥野友紀子; 和根崎圭子; 吉田優; 隅田ともえ; 井上治久; 細谷孝充; 萩原正敏日本生化学会大会(Web), Dec. 2017
External funds: Kakenhi
- Identification of the mechanism inducing reactive astrocyte in neuroinflammatory condition as a therapeutic target.Grant-in-Aid for Scientific Research (C)Basic Section 51030:Pathophysiologic neuroscience-relatedKyoto UniversityAkiko KobayashiFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed神経炎症;アストロサイト;アストログリア
- Development of neurogenesis inducer for neurodegenerative disordersGrant-in-Aid for Scientific Research (C)Kyoto UniversityAkiko KOBAYASHIFrom 01 Apr. 2016, To 31 Mar. 2019, Project Closed神経新生;ダウン症;シーズ探索;神経発達;化合物探索
- アストロサイト形質転換の分子機序解明と創薬標的の探索Grant-in-Aid for Scientific Research (B)Basic Section 49010:Pathological biochemistry-relatedKyoto University小林 亜希子From 01 Apr. 2022, To 31 Mar. 2025, Granted神経炎症
- アストロサイト形質転換の分子機序解明と創薬標的の探索Grant-in-Aid for Scientific Research (B)Basic Section 49010:Pathological biochemistry-relatedKyoto University小林 亜希子From 01 Apr. 2022, To 31 Mar. 2025, Granted神経炎症
