Gan, Hilotetsu(Graduate School of Biostudies, Division of Integrated Life Science) | Activity Database on Education and Research, Kyoto University

Gan, Hilotetsu

Graduate School of Biostudies, Division of Integrated Life Science

Last Updated :2026/08/20

Basic Information

Email Address

Email Address
gan.hilotetsu.4skyoto-u.ac.jp

Research History

From Jul. 2023, To Present
Osaka University, 生殖生物学, 研究員

From Oct. 2014, To Mar. 2023
Osaka University, Graduate School of Medicine Division of Health Sciences, Assistant Professor

From Apr. 2014, To Sep. 2014
Osaka University, WPI Immunology Frontier Research Center, PostDoc

From Apr. 2011, To Mar. 2014
Osaka University, Graduate School of Medicine, Assistant Professor

ID,URL

J-Global ID
201801006554309603

researchmap URL

https://researchmap.jp/hiloyen

Last Updated :2026/08/20

Research

Research Interests

Infectious diseases, Immune responses, EPEC, EHEC, effectors, Regulation of pathogenesis

Research Areas

Life sciences, Molecular biology, 生殖細胞

Life sciences, Bacteriology

Papers

A novel toxin–antitoxin system swpAB alters gene expression patterns and reduces virulence expression in enterohemorrhagic Escherichia coli
Shinya Ebihara; Hilo Yen; Toru Tobe
Microbiology and Immunology, 24 Feb. 2023, Peer-reviewed

SlyA regulates virulence gene expressions through activation of pchA regulatory gene in enterohemorrhagic Escherichia coli.
Riho Hamamura; Hilo Yen; Toru Tobe
Microbiology and immunology, Nov. 2022, Peer-reviewed

Enterohaemorrhagic Escherichia coli activates nitrate respiration to benefit from the inflammatory response for initiation of microcolony-formation.
Risa Nada; Shinya Ebihara; Hilo Yen; Toru Tobe
BMC microbiology, 20 Aug. 2020, Peer-reviewed

Enterohaemorrhagic Escherichia coli activates nitrate respiration to benefit from the inflammatory response for acceleration of infection
Risa Nada; Shinya Ebihara; Hilo Yen; Toru Tobe
BMC Microbiology, 23 Mar. 2020, Peer-reviewed

Activation of lpxR gene through enterohaemorrhagic Escherichia coli virulence regulators mediates lipid A modification to attenuate innate immune response
Rikako Ogawa; Hilo Yen; Kiyoshi Kawasaki; Toru Tobe
CELLULAR MICROBIOLOGY, Jan. 2018, Peer-reviewed

Enterohaemorrhagic Escherichia coli produces outer membrane vesicles as an active defence system against antimicrobial peptide LL-37
Akiko Urashima; Ayano Sanou; Hilo Yen; Toru Tobe
CELLULAR MICROBIOLOGY, Nov. 2017, Peer-reviewed

Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli
Hilo Yen; Masaski Karino; Toru Tobe
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, Aug. 2016, Peer-reviewed, Invited

Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation
Hilo Yen; Nakaba Sugimoto; Toru Tobe
PLOS PATHOGENS, Sep. 2015, Peer-reviewed

LeuO enhances butyrate-induced virulence expression through a positive regulatory loop in enterohaemorrhagic Escherichia coli
Miyuki Takao; Hilo Yen; Toru Tobe
MOLECULAR MICROBIOLOGY, Sep. 2014, Peer-reviewed

Antisense Transcription Regulates the Expression of the Enterohemorrhagic Escherichia coli Virulence Regulatory Gene ler in Response to the Intracellular Iron Concentration
Toru Tobe; Hilo Yen; Hiroki Takahashi; Yoko Kagayama; Naotake Ogasawara; Taku Oshima
PLOS ONE, Jul. 2014, Peer-reviewed

DNA looping-dependent autorepression of LEE1 P1 promoters by Ler in enteropathogenic Escherichia coli (EPEC)
Abhayprasad Bhat; Minsang Shin; Jae-Ho Jeong; Hyun-Ju Kim; Hyung-Ju Lim; Joon Haeng Rhee; Soon-Young Paik; Kunio Takeyasu; Toru Tobe; Hilo Yen; Gwangrog Lee; Hyon E. Choy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2014, Peer-reviewed

NleC, a Type III Secretion Protease, Compromises NF-kappa B Activation by Targeting p65/RelA
Hilo Yen; Tadasuke Ooka; Atsushi Iguchi; Tetsuya Hayashi; Nakaba Sugimoto; Toru Tobe
PLOS PATHOGENS, Dec. 2010, Peer-reviewed

Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation
Daijiro Sugiyama; Makoto Tanaka; Kenji Kitajima; Jie Zheng; Hilo Yen; Tomotaka Murotani; Atsushi Yamatodani; Toru Nakano
BLOOD, Feb. 2008, Peer-reviewed

Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2
K Kitajima; M Tanaka; J Zheng; H Yen; A Sato; D Sugiyama; H Umehara; E Sakai; T Nakano
BLOOD, Mar. 2006, Peer-reviewed

Multipotential differentiation ability of GATA-1-null erythroid-committed cells
K Kitajima; J Zheng; HL Yen; D Sugiyama; T Nakano
GENES & DEVELOPMENT, Mar. 2006, Peer-reviewed

Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2.
Kitajima K; Tanaka M; Zheng J; Yen H; Sato A; Sugiyama D; Umehara H; Sakai E; Nakano T
Blood, Mar. 2006, Peer-reviewed

External funds: Kakenhi

Identification of EHEC virulent factors in exosome and its functional role during the infection
Grant-in-Aid for Scientific Research (C)
Basic Section 49050:Bacteriology-related
Osaka University
Hilo Yen
From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
EPEC;inflammation;exosome;effector;T3SS;エクソソーム;EHEC;感染;炎症応答;Infection;Exosome;Immune response;Effector
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07538/

The interference of host exosome releases by entropathogenic Escherichia coli
Grant-in-Aid for Young Scientists (B)
Osaka University
Hilo Yen
From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
EPEC;Effector;T3SS;Exosome;Immune response;infection;エクソソーム;EHEC;Infection;Effectors;病原性大腸菌;エフェクター;細胞外小膜;感染症;腸管出血性大腸菌
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19126/

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