Basic Information

Email Address

• Email Address

  mori.mayumi.7ukyoto-u.ac.jp

Academic Degree

• 24 Mar. 2008

  東京大学修士（薬学）
• 22 Mar. 2012

  東京大学博士（医学）

Academic Resume (Graduate Schools)

• 東京大学, 大学院医学系研究科博士課程分子細胞生物学専攻, 修了
• 東京大学, 大学院薬学系研究科修士課程機能薬学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 薬学部薬学科, 卒業

Research History

• From Apr. 2022, To Sep. 2022

  神戸医療産業都市推進機構, 先端医療センター・アカデミア連携部, 客員研究員
• From Apr. 2022, To Present

  Kyoto University, Graduate School of Medicine, Senior Lecturer, Senior Lecturer (Endowed)
• From Apr. 2021, To Mar. 2022

  神戸医療産業都市推進機構, 先端医療センター・老化機構研究部, 特任主任研究員
• From Dec. 2016, To Mar. 2021

  University of Basel, Biozentrum, Postdoctoral fellow
• From Apr. 2015, To Nov. 2016

  Universitätsklinikum Hamburg-Eppendorf, Geburtshilfe und Pränatalmedizin, Post-doctoral fellow
• From May 2013, To Mar. 2015

  The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Endowed Assistant Professor
• From Apr. 2012, To Mar. 2013

  The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, 日本学術振興会 特別研究員 PD
• From Apr. 2011, To Mar. 2012

  The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, 日本学術振興会 特別研究員 DC2
• From Apr. 2008, To Mar. 2011

  The University of Tokyo, Graduate School of Medicine, グローバルCOE リサーチアシスタント

ID,URL

• ORCID ID

  0000-0001-6190-9785

• J-Global ID

  202101012471789153

researchmap URL

• https://researchmap.jp/irpamorifbri

Research

Research Areas

• Life sciences, Tumor biology, Hepatocellular carcinoma, Lymphoma
• Life sciences, Immunology, T cells, Signalling, Autoimmunity
• Life sciences, Obstetrics and gynecology, Infertility, Decidua
• Life sciences, Molecular biology, Cell cycle, Apoptosis

Papers

• Coronin 1-dependent cell density sensing and regulation of the peripheral T cell population size

  Tohnyui Ndinyanka Fabrice; Mayumi Mori; Jean Pieters

  Oxford Open Immunology, 14 Mar. 2024, Peer-reviewed

  
• An evolutionarily conserved coronin-dependent pathway defines cell population size

  Tohnyui Ndinyanka Fabrice; Christelle Bianda; Haiyan Zhang; Rajesh Jayachandran; Julie Ruer-Laventie; Mayumi Mori; Despina Moshous; Geoffrey Fucile; Alexander Schmidt; Jean Pieters

  Science Signaling, 08 Nov. 2022, Peer-reviewed

  
• Suppression of caspase 8 activity by a coronin 1–PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling

  Mayumi Mori; Julie Ruer-Laventie; Wandrille Duchemin; Philippe Demougin; Tohnyui Ndinyanka Fabrice; Matthias P. Wymann; Jean Pieters

  Science Signaling, 21 Dec. 2021, Peer-reviewed, Lead author

  
• Getting in and Staying Alive: Role for Coronin 1 in the Survival of Pathogenic Mycobacteria and Naïve T Cells

  Mayumi Mori

  Frontiers in Immunology, 10 Jul. 2018, Invited, Lead author

  
• From Phagocytes to Immune Defense: Roles for Coronin Proteins in Dictyostelium and Mammalian Immunity

  Mayumi Mori

  Frontiers in Immunology, 22 Mar. 2018, Invited, Lead author

  
• A Coronin 1–Dependent Decision Switch in Juvenile Mice Determines the Population of the Peripheral Naive T Cell Compartment

  Mathias Jakob Lang; Mayumi Mori; Julie Ruer-Laventie; Jean Pieters

  The Journal of Immunology, 01 Oct. 2017, Peer-reviewed, Lead author

  
• The decidua—the maternal bed embracing the embryo—maintains the pregnancy

  Mayumi Mori; Agnes Bogdan; Timea Balassa; Timea Csabai; Júlia Szekeres-Bartho

  Seminars in Immunopathology, 10 Jun. 2016, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures.

  Mayumi Mori

  Cell Adhesion and Migration, 03 Mar. 2016, Peer-reviewed

  
• Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice.

  Satoko Arai; Kento Kitada; Tomoko Yamazaki; Ryosuke Takai; Xizhong Zhang; Yoji Tsugawa; Ryoichi Sugisawa; Ayaka Matsumoto; Mayumi Mori; Yasunori Yoshihara; Kent Doi; Natsumi Maehara; Shunsuke Kusunoki; Akiko Takahata; Eisei Noiri; Yusuke Suzuki; Naoki Yahagi; Akira Nishiyama; Lakshman Gunaratnam; Tomoko Takano; Toru Miyazaki

  Nature Medicine, Feb. 2016, Peer-reviewed

  
• Circulating AIM as an indicator of liver damage and hepatocellular carcinoma in humans.

  Yamazaki T; Mori M; Arai S; Tateishi R; Abe M; Ban M; Nishijima A; Maeda M; Asano T; Kai T; Izumino K; Takahashi J; Aoyama K; Harada S; Takebayashi T; Gunji T; Ohnishi S; Seto S; Yoshida Y; Hiasa Y; Koike K; Yamamura K; Inoue K; Miyazaki T

  PLoS One, 10 Oct. 2014, Peer-reviewed

  
• Circulating AIM prevents hepatocellular carcinoma through complement activation.

  Natsumi Maehara; Satoko Arai; Mayumi Mori; Yoshihiro Iwamura; Jun Kurokawa; Toshihiro Kai; Shunsuke Kusunoki; Kaori Taniguchi; Kazutaka Ikeda; Osamu Ohara; Ken-ichi Yamamura; Toru Miyazaki

  Cell Reports, 09 Oct. 2014, Peer-reviewed, Lead author

  
• Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.

  Satoko Arai; Natsumi Maehara; Yoshihiro Iwamura; Shin-ichiro Honda; Katsuhiko Nakashima; Toshihiro Kai; Masato Ogishi; Kumiko Morita; Jun Kurokawa; Mayumi Mori; Yuji Motoi; Kensuke Miyake; Nobuyuki Matsuhashi; Ken-ichi Yamamura; Osamu Ohara; Akira Shibuya; Edward K. Wakel; Quan-Zhen Li; Toru Miyazaki

  Cell Reports, 25 Apr. 2013, Peer-reviewed

  
• Modification of N-glycosylation modulates the secretion and lipolytic function of Apoptosis Inhibitor of Macrophage (AIM).

  Mayumi Mori; Hiroki Kimura; Yoshihiro Iwamura; Satoko Arai; Toru Miyazaki

  FEBS Letters, 19 Oct. 2012, Peer-reviewed, Lead author

  
• Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes.

  Yoshihiro Iwamura; Mayumi Mori; Katsuhiko Nakashima; Toshiyuki Mikami; Katsuhisa Murayama; Satoko Arai; Toru Miyazaki

  Biochemical and Biophysical Research Communications, 08 Jun. 2012, Peer-reviewed

  
• Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.

  Mayumi Mori; Miwako Kitazume; Rui Ose; Jun Kurokawa; Kaori Koga; Yutaka Osuga; Satoko Arai; Toru Miyazaki

  Journal of Clinical Investigation, Jan. 2011, Peer-reviewed, Lead author

  
• AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.

  Jun Kurokawa; Satoko Arai; Katsuhiko Nakashima; Hiromichi Nagano; Akemi Nishijima; Keishi Miyata; Rui Ose; Mayumi Mori; Naoto Kubota; Takashi Kadowaki; Yuichi Oike; Hisashi Koga; Maria Febbraio; Toshihiko Iwanaga; Toru Miyazaki

  Cell Metabolism, 09 Jun. 2010, Peer-reviewed

  
• The Death Effector Domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.

  Nobuya Kurabe; Mayumi Mori; Jun Kurokawa; Kaori Taniguchi; Hisatoshi Aoyama; Kazuhiro Atsuda; Akemi Nishijima; Nariaki Odawara; Saori Harada; Katsuhiko Nakashima; Satoko Arai; Toru Miyazaki

  Biochemical and Biophysical Research Communications, 22 Jan. 2010, Peer-reviewed

  
• The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.

  Kurabe N; Arai S; Nishijima A; Kubota N; Suizu F; Mori M; Kurokawa J; Kondo-Miyazaki M; Ide T; Murakami K; Miyake K; Ueki K; Koga H; Yatomi Y; Tashiro F; Noguchi M; Kadowaki T; Miyazaki T

  The Journal of Biological Chemistry, 20 Feb. 2009, Peer-reviewed

  

Misc.

• A Novel View for the Mechanism of Female Infertility in the Context of Metabolism Within Decidual Cells

  Mayumi Mori; Toru Miyazaki

  BIOLOGY OF REPRODUCTION, Jul. 2011

  
• The Death Effector Domain-Containing DEDD Is Required for Uterine Decidualization and Female Fertility During Early Pregnancy

  Mayumi Mori; Satoko Arai; Tom Miyazaki

  BIOLOGY OF REPRODUCTION, 2010

  
• Faculty Opinions recommendation of CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.

  Jean Pieters; Mayumi Mori

  Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 09 May 2017, Last author

  
• 不妊症の新しいメカニズム ―初期妊娠の子宮環境における DEDD 分子の重要性―

  森 真弓; 新井 郷子; 宮崎 徹

  日本生殖内分泌学会雑誌, 2011, Lead author

  

Presentations

• T細胞の生存シグナル

  森 真弓

  金沢大学がん進展制御研究所 中央実験施設セミナー, 10 Jun. 2022, Invited

  

Books and Other Publications

• Series モデル動物利⽤マニュアル: 脂質代謝異常と関連疾患

  森 真弓; 宮崎 徹, Contributor, 第４章 ２節 AIM

  エル・アイ・シー, Jan. 2015

  Find Kyoto University's collection of books :

  

Awards

• 24 Sep. 2011

  鈴木紘一メモリアル賞(日本生化学会)
• 21 Nov. 2010

  日本生殖内分泌学会学術奨励賞

External funds: Kakenhi

• ビタミンDによる免疫老化におけるエピジェネティック制御機構

  Grant-in-Aid for Scientific Research (C)

  Basic Section 59040:Nutrition science and health science-related

  Kyoto University

  森 真弓

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  ビタミンD;免疫老化;DNAメチル化;エピジェネティクス;免疫;老化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K11745/
• Roles for senescence factors of the cellular metabolism in the anti-cancer T-cell immunity

  Grant-in-Aid for Research Activity Start-up

  0702:Biology at cellular to organismal levels, and related fields

  Kyoto University;Foundation for Biomedical Research and Innovation at Kobe

  Mayumi Mori

  From 30 Aug. 2021, To 31 Mar. 2024, Project Closed

  老化;がん免疫;代謝;免疫老化;T細胞;免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K20670/
• 不妊症の新しい病態　―胎盤形成前の子宮組織における血管のダイナミズム―

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  森 真弓

  From 01 Apr. 2014, To 31 Mar. 2015, Discontinued

  不妊症;血管内皮;DEDD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26861314/

External funds: others

• Analysis of the role for coronin 1-dependent cell density signalling in T-cell homeostasis

  Immunology

  European Commission, Marie Skłodowska-Curie Actions Individual Fellowships

  From 01 Jan. 2019, To 02 Mar. 2021
• 脂肪肝から肝癌へと導く NASH の新規病態メカニズム解明と予防・治療戦略

  腫瘍生物学

  公益財団法人 小野医学研究財団, 研究奨励助成

  From 01 Apr. 2014, To 31 Mar. 2015
• 脂肪肝から肝癌へと導く NASH の新規病態メカニズム解明と予防・治療戦略

  腫瘍生物学

  公益財団法人 武田科学振興財団, 医学系研究助成

  From 01 Sep. 2013, To 31 Mar. 2018
• 脂肪肝から起こる肝細胞がんに対する血中 AIM 分子の予防的効果

  腫瘍生物学

  公益財団法人東京生化学研究会, 研究助成

  From 01 Apr. 2013, To 31 Mar. 2014

Academic, Social Contribution

Committee Memberships

• From Apr. 2021, To Present

  Editorial Board member, Journal of Autoimmunity