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Mu, Anfeng

Graduate School of Biostudies, Division of Systemic Life Science Assistant Professor

Mu, Anfeng
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    Last Updated :2025/04/23

    Basic Information

    Professional Memberships

    • 日本放射線影響学会
    • 日本分子生物学会

    Academic Degree

    • 博士（医学）(京都大学)
    • 修士（農学）(京都工芸繊維大学)

    Research History

    • From Jan. 2024, To Present
      Kyoto University, Graduate School of Biostudies, Assistant Professor
    • From Apr. 2020, To Mar. 2021
      Kyoto University, Graduate School of Biostudies, 教務補佐員
    • From Jan. 2022, To Dec. 2023
      Kyoto University, Graduate School of Biostudies, 特定助教
    • From Apr. 2021, To Dec. 2021
      Kyoto University, Graduate School of Biostudies, 研究員

    ID,URL

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    list
      Last Updated :2025/04/23

      Research

      Research Areas

      • Life sciences, Genomics
      • Life sciences, Medical biochemistry
      • Life sciences, Genetics
      • Life sciences, Molecular biology

      Papers

      • The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway
        Anfeng Mu; Yusuke Okamoto; Yoko Katsuki; Minoru Takata
        DNA Repair, Jul. 2024, Peer-reviewed, Invited, Lead author, Corresponding author
      • Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response
        Erin Alvi; Ayako L. Mochizuki; Yoko Katsuki; Minori Ogawa; Fei Qi; Yusuke Okamoto; Minoru Takata; Anfeng Mu
        Communications Biology, 13 Oct. 2023, Peer-reviewed, Last author, Corresponding author
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      • Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model
        Anfeng Mu; Zimu Cao; Denggao Huang; Hiroshi Hosokawa; Shingo Maegawa; Minoru Takata
        Molecular Biology Reports, 24 Aug. 2023, Peer-reviewed, Lead author, Corresponding author
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      • Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome: metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA Damage
        Anfeng Mu; Asuka Hira; Minako Mori; Yusuke Okamoto; Minoru Takata
        DNA Repair, Aug. 2023, Peer-reviewed, Invited, Lead author
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      • The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response
        Fei Qi; Erin Alvi; Minori Ogawa; Junya Kobayashi; Anfeng Mu; Minoru Takata
        Genes to Cells, 19 Jul. 2023, Peer-reviewed, Corresponding author
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      • Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers
        Tomoharu Mori; Yusuke Okamoto; Anfeng Mu; Yoshimi Ide; Akiyo Yoshimura; Noriko Senda; Yukiko Inagaki‐Kawata; Masahiro Kawashima; Hiroyuki Kitao; Eriko Tokunaga; Yasuo Miyoshi; Shozo Ohsumi; Koichiro Tsugawa; Tomohiko Ohta; Toyomasa Katagiri; Shigeru Ohtsuru; Kaoru Koike; Seishi Ogawa; Masakazu Toi; Hiroji Iwata; Seigo Nakamura; Keitaro Matsuo; Minoru Takata
        Cancer Medicine, 07 Nov. 2022, Peer-reviewed
      • Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency
        Anfeng Mu; Asuka Hira; Akira Niwa; Mitsujiro Osawa; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Kazuko Inoue; Keita Kondo; Masato T. Kanemaki; Tomonari Matsuda; Etsuro Ito; Seiji Kojima; Tatsutoshi Nakahata; Seishi Ogawa; Keigo Tanaka; Keitaro Matsuo; Megumu K. Saito; Minoru Takata
        Blood, 15 Apr. 2021, Peer-reviewed, Lead author
      • SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells
        Yusuke Okamoto; Masako Abe; Anfeng Mu; Yasuko Tempaku; Colette B. Rogers; Ayako L. Mochizuki; Yoko Katsuki; Masato T. Kanemaki; Akifumi Takaori-Kondo; Alexandra Sobeck; Anja-Katrin Bielinsky; Minoru Takata
        Blood, 21 Jan. 2021, Peer-reviewed
      • [Aldehyde degradation deficiency (ADD) syndrome: discovery of a novel fanconi anemia-like inherited BMF syndrome due to combined ADH5/ALDH2 deficiency].
        Anfeng Mu; Asuka Hira; Keitaro Matsuo; Minoru Takata
        [Rinsho ketsueki] The Japanese journal of clinical hematology, 2021, Peer-reviewed, Lead author
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      • Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans
        Felix A. Dingler; Meng Wang; Anfeng Mu; Christopher L. Millington; Nina Oberbeck; Sam Watcham; Lucas B. Pontel; Ashley N. Kamimae-Lanning; Frederic Langevin; Camille Nadler; Rebecca L. Cordell; Paul S. Monks; Rui Yu; Nicola K. Wilson; Asuka Hira; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Yusuke Okuno; Hideki Muramatsu; Yuichi Shiraishi; Masayuki Kobayashi; Toshinori Moriguchi; Tomoo Osumi; Motohiro Kato; Satoru Miyano; Etsuro Ito; Seiji Kojima; Hiromasa Yabe; Miharu Yabe; Keitaro Matsuo; Seishi Ogawa; Berthold Göttgens; Michael R.G. Hodskinson; Minoru Takata; Ketan J. Patel
        Molecular Cell, Nov. 2020, Peer-reviewed, Lead author
      • Enhancements of the production of bilirubin and the expression of β-globin by carbon monoxide during erythroid differentiation
        Anfeng Mu; Ming Li; Masakazu Tanaka; Yasushi Adachi; Tran Tien Tai; Pham Hieu Liem; Shingo Izawa; Kazumichi Furuyama; Shigeru Taketani
        FEBS Letters, May 2016, Peer-reviewed, Lead author
      • A simple and highly sensitive method of measuring heme oxygenase activity
        Pham Hieu Liem; Anfeng Mu; Shun-ichi Kikuta; Kazushi Ohta; Sakihito Kitajima; Shigeru Taketani
        Biological Chemistry, 01 Nov. 2015, Peer-reviewed
      • Continuous de novo biosynthesis of haem and its rapid turnover to bilirubin are necessary for cytoprotection against cell damage
        Taka-aki Takeda; Anfeng Mu; Tran Tien Tai; Sakihito Kitajima; Shigeru Taketani
        Scientific Reports, Sep. 2015, Peer-reviewed
      • p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron
        Rina Shimizu; Nguyen Ngoc Lan; Tran Tien Tai; Yuka Adachi; Asako Kawazoe; Anfeng Mu; Shigeru Taketani
        Gene, Nov. 2014, Peer-reviewed
      • Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells
        Tai Tien Tran; Anfeng Mu; Yuka Adachi; Yasushi Adachi; Shigeru Taketani
        Photochemistry and Photobiology, Sep. 2014, Peer-reviewed
      • Imaging of heme/hemeproteins in nucleus of the living cells expressing heme‐binding nuclear receptors
        Ryuhei Itoh; Ken-ichi Fujita; Anfeng Mu; Dao Hoang Thien Kim; Tran Tien Tai; Ikuko Sagami; Shigeru Taketani
        FEBS Letters, 11 Jul. 2013, Peer-reviewed

      Misc.

      • aldehyde degradation deficiency（ADD）症候群：アルデヒド代謝酵素ADH5/ALDH2欠損による新規遺伝性再生不良性貧血
        牟 安峰; 高田 穣
        生化学, Jan. 2022, Invited, Lead author
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      • iPS細胞を用いたファンコニ貧血研究の新展開
        牟 安峰; 高田 穣
        血液内科, Dec. 2021, Invited, Lead author

      Presentations

      • Insights into the Schlafen gene family—Functional parallels in mice and humans
        Anfeng Mu; Minoru Takata; Takaaki Yasuhara
        Cold Spring Harbor Asia-2024 DNA Metabolism, Genomic Stability & Human Diseases, 04 Jun. 2024
      • SLFN11 promotes fork degradation during the replication stress
        牟 安峰; 髙田 穣
        第46回日本分子生物学会年会, 06 Dec. 2023, Invited
      • Fanconi anemia and Aldehyde Degradation Deficiency (ADD) Syndrome.
        Anfeng Mu
        The 19th Ataxia-Telangiectasia workshop., 05 Mar. 2023
      • Fanconi anemia and Aldehyde Degradation Deficiency (ADD) Syndrome: DNA repair and metabolism together protect the genome and hematopoiesis.
        Anfeng Mu
        Sussex Japan Genome Stability Meeting, 20 Jan. 2023
      • 新規骨髄不全症ADDSの発見とモデルiPS細胞による病態・治療法検討
        牟 安峰
        第17回血液学若手研究者勉強会（麒麟塾）, 23 Jul. 2022, Invited
      • 新規遺伝性骨髄不全症アルデヒド分解不全(ADD)症候群の発見：代謝異常によって引き起こされるゲノム不安定性
        牟 安峰; 平 明日; 丹羽 明; 大澤 光次郎; 森 美奈子; 岡本 裕介; 齋藤 潤; 高田 穣
        第44回日本分子生物学会年会, 03 Dec. 2021
      • Discovery of a novel FA-like disorder Aldehyde Degradation Deficiency (ADD) Syndrome caused by ADH5/ALDH2 mutations
        Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Minako Mori, Yusuke Okamoto, Megumu K. Saito, Minoru Takata
        33rd Fanconi Anemia Scientific Symposium, 16 Jul. 2021
      • Aldehyde clearance by ADH5 and ALDH2 is essential for human hematopoiesis.
        Anfeng Mu; Asuka Hira; Minako Mori; Yusuke Okamoto; Minoru Takata
        2020 NTU-KU-UT Virtual-Physical students mini-symposium on Cancer Biology and Medicine., 19 Dec. 2020, Invited

      External funds: Kakenhi

      • 骨髄不全症モデルiPS細胞におけるADH5/ALDH2に着目した病態・治療法検討
        Grant-in-Aid for Early-Career Scientists
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        牟 安峰
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        Fanconi anemia;ADH5;ALDH2;UBE2T;iPSC;造血分化;ADD;ホルムアルデヒド;formaldehyde;骨髄不全
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15362/
      • Genome-stabilizing activity of aldehyde catalyzing enzymes that support epigenetic reprogramming
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Kyoto University
        高田 穣
        From 30 Jul. 2020, To 31 Mar. 2024, Granted
        ADH5;ALDH2;ADD syndrome;Fanconi anemia;iPS cells;reprogramming;エピゲノム再構成;フォルムアルデヒド;ゲノム損傷;iPS細胞;リプログラミング;アルデヒド;エピジェネティックリプログラミング;脱メチル化酵素
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21394/
      • The role of SLFN11 gene that determines DNA damage sensitivity at the stalled replication forks
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49010:Pathological biochemistry-related
        Kyoto University
        Minoru Takata
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        SLFN11;複製ストレス;複製フォーク;RAD51;DNA2;MRE11;癌化学療法;DNAファイバー法;SLFNファミリー;ファンコニ貧血;複製フォーク分解;FANCD2;複製フォーク停止;DNA損傷
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03450/
      • Fanconi anemia経路に着目したiPS細胞における高レベル複製ストレスの原因解明
        Grant-in-Aid for Early-Career Scientists
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        牟 安峰
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        Fanconi anemia;FANCD2;UBE2T;複製ストレス;ゲノム不安定性
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14452/

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