Basic Information

Faculty

• 医学部

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Apr. 2020, To Present

  Kyoto University, 医学研究科, 教授
• From Apr. 2010, To Mar. 2020

  Hokkaido University, Institute for Genetic Medicine, 教授

ID,URL

• J-Global ID

  201301028852887314

• External link

  http://kaken.nii.ac.jp/d/r/50580974.ja.html

researchmap URL

• https://researchmap.jp/1234munc

Research

Research Interests

• 新規癌治療法
• 癌
• Cell Cometition
• 細胞培養
• 上皮細胞

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Cell biology

Papers

• Mechanical convergence in mixed populations of mammalian epithelial cells.

  Estelle Gauquelin; Keisuke Kuromiya; Toshinori Namba; Keisuke Ikawa; Yasuyuki Fujita; Shuji Ishihara; Kaoru Sugimura

  The European physical journal. E, Soft matter, 27 Mar. 2024

  
• Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.

  Shoko Ito; Keisuke Kuromiya; Miho Sekai; Hiroaki Sako; Kazuhito Sai; Riho Morikawa; Yohei Mukai; Yoko Ida; Moe Anzai; Susumu Ishikawa; Kei Kozawa; Takanobu Shirai; Nobuyuki Tanimura; Kenta Sugie; Junichi Ikenouchi; Motoyuki Ogawa; Isao Naguro; Hidenori Ichijo; Yasuyuki Fujita

  Proceedings of the National Academy of Sciences of the United States of America, 24 Oct. 2023

  
• Wnt activation-induced disturbance of cell competition causes diffuse invasion of transformed cells through upregulation of NF-κB-mediated MMP21

  Kazuki Nakai; Hancheng Lin; Shotaro Yamano; Shinya Tanaka; Sho Kitamoto; Kenta Sakuma; Junpei Kurauchi; Eilma Akter; Masamitsu Konno; Jun Koseki; Hirotaka Takahashi; Hideshi Yokoyama; Yukihiro Shiraki; Atsushi Enomoto; Sohei Abe; Yoku Hayakawa; Tetsuo Ushiku; Michihiro Mutoh; Yasuyuki Fujita; Shunsuke Kon

  Nature Communications, 15 Dec. 2022

  
• Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae

  H Kohno; K Tanaka; A Mino; M Umikawa; H Imamura; T Fujiwara; Y Fujita; K Hotta; H Qadota; T Watanabe; Y Ohya; Y Takai

  EMBO JOURNAL, Nov. 1996, Peer-reviewed

  
• Basal extrusion of single‐oncogenic mutant cells induces dome‐like structures with altered microenvironments

  Takanobu Shirai; Miho Sekai; Kei Kozawa; Nanami Sato; Nobuyuki Tanimura; Shunsuke Kon; Tomohiro Matsumoto; Takeru Murakami; Shoko Ito; Andrew Tilston‐Lunel; Xaralabos Varelas; Yasuyuki Fujita

  Cancer Science, 30 Aug. 2022, Peer-reviewed

  
• Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition

  Kentaro Kajiwara; Ping Kuan Chen; Yuichi Abe; Satoru Okuda; Shunsuke Kon; Jun Adachi; Takeshi Tomonaga; Yasuyuki Fujita; Masato Okada

  Current Biology, 22 Aug. 2022, Peer-reviewed

  
• Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.

  Nanase Igarashi; Kenichi Miyata; Tze Mun Loo; Masatomo Chiba; Aki Hanyu; Mika Nishio; Hiroko Kawasaki; Hao Zheng; Shinya Toyokuni; Shunsuke Kon; Keiji Moriyama; Yasuyuki Fujita; Akiko Takahashi

  Nature communications, 18 Jul. 2022, Peer-reviewed

  
• Non-degradable autophagic vacuoles are indispensable for cell competition

  Eilma Akter; Yukihiro Tasaki; Yusuke Mori; Kazuki Nakai; Kazuki Hachiya; Hancheng Lin; Masamitsu Konno; Tomoko Kamasaki; Kenji Tanabe; Yumi Umeda; Shotaro Yamano; Yasuyuki Fujita; Shunsuke Kon

  Cell Reports, Aug. 2022, Peer-reviewed

  
• Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells

  Keisuke Kuromiya; Kana Aoki; Kojiro Ishibashi; Moe Yotabun; Miho Sekai; Nobuyuki Tanimura; Sayuri Iijima; Susumu Ishikawa; Tomoko Kamasaki; Yuki Akieda; Tohru Ishitani; Takashi Hayashi; Satoshi Toda; Koji Yokoyama; Chol Gyu Lee; Ippei Usami; Haruki Inoue; Ichigaku Takigawa; Estelle Gauquelin; Kaoru Sugimura; Naoya Hino; Yasuyuki Fujita

  Cell Reports, Jul. 2022, Peer-reviewed

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• A novel function of the C-terminal lipid moieties of Rab3A small G protein implicated in Ca2+-dependent exocytosis - Inhibition of interaction with CTP and reduction of this inhibition by phospholipid

  Y Jinno; H Shirataki; T Senbonmatsu; T Yamamoto; Y Fujita; H Nakanishi; Y Takai

  GENES TO CELLS, Apr. 1997, Peer-reviewed

  
• Ultrastructural Characteristics of Finger-Like Membrane Protrusions in Cell Competition.

  Tomoko Kamasaki; Ryota Uehara; Yasuyuki Fujita

  Microscopy (Oxford, England), 08 Apr. 2022, Peer-reviewed

  
• Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.

  Shiyu Ayukawa; Nagisa Kamoshita; Jun Nakayama; Ryohei Teramoto; Novalia Pishesha; Kenji Ohba; Nanami Sato; Kei Kozawa; Hikari Abe; Kentaro Semba; Nobuhito Goda; Yasuyuki Fujita; Takeshi Maruyama

  Nature immunology, Nov. 2021

  
• Cell competition in vertebrates - a key machinery for tissue homeostasis.

  Takeshi Maruyama; Yasuyuki Fujita

  Current opinion in genetics & development, 08 Oct. 2021

  
• Tumor-Cell Invasion Initiates at Invasion Hotspots, an Epithelial Tissue-Intrinsic Microenvironment

  Rei Kobayashi; Hiroaki Takishima; Sheng Deng; Yasuyuki Fujita; Yoichiro Tamori

  29 Sep. 2021

  
• Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis

  Yusuke Mori; Naoka Shiratsuchi; Nanami Sato; Azusa Chaya; Nobuyuki Tanimura; Susumu Ishikawa; Mugihiko Kato; Ikumi Kameda; Shunsuke Kon; Yukinari Haraoka; Tohru Ishitani; Yasuyuki Fujita

  Current Biology, May 2022, Peer-reviewed

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• Sequential oncogenic mutations influence cell competition

  Koki Kohashi; Yusuke Mori; Rika Narumi; Kei Kozawa; Tomoko Kamasaki; Susumu Ishikawa; Mihoko Kajita; Rei Kobayashi; Yoichiro Tamori; Yasuyuki Fujita

  Current Biology, Sep. 2021, Peer-reviewed

  
• Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis

  Shunsuke Kon; Yasuyuki Fujita

  Developmental Biology, Aug. 2021, Peer-reviewed

  
• Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly.

  Kazuya Tsujita; Reiko Satow; Shinobu Asada; Yoshikazu Nakamura; Luis Arnes; Keisuke Sako; Yasuyuki Fujita; Kiyoko Fukami; Toshiki Itoh

  Nature communications, 11 Oct. 2021

  
• FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

  Tomoko Kamasaki; Yumi Miyazaki; Susumu Ishikawa; Kazuya Hoshiba; Keisuke Kuromiya; Nobuyuki Tanimura; Yusuke Mori; Motosuke Tsutsumi; Tomomi Nemoto; Ryota Uehara; Shiro Suetsugu; Toshiki Itoh; Yasuyuki Fujita

  iScience, Aug. 2021, Peer-reviewed

  
• A Ca2+ wave generates a force during cell extrusion in zebrafish

  Sohei Yamada; Yasumasa Bessho; Yasuyuki Fujita; Yoichiroh Hosokawa; Takaaki Matsui

  14 Jul. 2021

  
• The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

  Kei Kozawa; Miho Sekai; Kenji Ohba; Shoko Ito; Hiroaki Sako; Takeshi Maruyama; Mai Kakeno; Takanobu Shirai; Keisuke Kuromiya; Tomoko Kamasaki; Koki Kohashi; Shinya Tanaka; Susumu Ishikawa; Nanami Sato; Shota Asano; Hironori Suzuki; Nobuyuki Tanimura; Yohei Mukai; Noriko Gotoh; Mishie Tanino; Shinya Tanaka; Ken Natsuga; Tomoyoshi Soga; Tomonori Nakamura; Yukihiro Yabuta; Mitinori Saitou; Takahiro Ito; Kenkyo Matsuura; Makoto Tsunoda; Toyone Kikumori; Tadashi Iida; Yasuyuki Mizutani; Yuki Miyai; Kozo Kaibuchi; Atsushi Enomoto; Yasuyuki Fujita

  Current Biology, Jun. 2021, Peer-reviewed

  
• PTEN is required for the migration and invasion of Ras‐transformed MDCK cells

  Lu Yan; Kazuya Tsujita; Yasuyuki Fujita; Toshiki Itoh

  FEBS Letters, May 2021, Peer-reviewed

  
• Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells

  Imen Jebri; Kazuya Tsujita; Yasuyuki Fujita; Toshiki Itoh

  Biochemical and Biophysical Research Communications, Mar. 2021, Peer-reviewed

  
• A common SNP risk variant MT1-MMP causative for Dupuytren's disease has a specific defect in collagenolytic activity

  Yoshifumi Itoh; Michael Ng; Akira Wiberg; Katsuaki Inoue; Narumi Hirata; Katiucia Batista Silva Paiva; Noriko Ito; Kim Dzobo; Nanami Sato; Valentina Gifford; Yasuyuki Fujita; Masaki Inada; Dominic Furniss

  Matrix Biology, Mar. 2021, Peer-reviewed

  
• FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

  Motoyuki Ogawa; Yosuke Kawarazaki; Yasuyuki Fujita; Isao Naguro; Hidenori Ichijo

  Current Biology, Mar. 2021, Peer-reviewed

  
• RasV12 Expression in Microglia Initiates Retinal Inflammation and Induces Photoreceptor Degeneration

  Yuta Moriuchi; Toshiro Iwagawa; Asano Tsuhako; Hideto Koso; Yasuyuki Fujita; Sumiko Watanabe

  Investigative Opthalmology & Visual Science, 24 Nov. 2020, Peer-reviewed

  
• ZAK inhibitor PLX4720 promotes extrusion of transformed cells via cell competition

  Takeshi Maruyama; Ayana Sasaki; Sayuri Iijima; Shiyu Ayukawa; Nobuhito Goda; Keisuke Tazuru; Norikazu Hashimoto; Takashi Hayashi; Kei Kozawa; Nanami Sato; Susumu Ishikawa; Tomoko Morita; Yasuyuki Fujita

  iScience, Jun. 2020, Peer-reviewed

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• The COX-2/PGE(2) pathway suppresses apical elimination of RasV12-transformed cells from epithelia

  Nanami Sato; Yuta Yako; Takeshi Maruyama; Susumu Ishikawa; Keisuke Kuromiya; Suzumi M. Tokuoka; Yoshihiro Kita; Yasuyuki Fujita

  COMMUNICATIONS BIOLOGY, Mar. 2020, Peer-reviewed

  
• Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition.

  Erika Ishihara; Yuya Nagaoka; Toshiaki Okuno; Satoshi Kofuji; Mari Ishigami-Yuasa; Hiroyuki Kagechika; Kenya Kamimura; Shuji Terai; Takehiko Yokomizo; Yukihiko Sugimoto; Yasuyuki Fujita; Akira Suzuki; Hiroshi Nishina

  Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2020, Peer-reviewed

  
• Calcium Wave Promotes Cell Extrusion.

  Yasuto Takeuchi; Rika Narumi; Ryutaro Akiyama; Elisa Vitiello; Takanobu Shirai; Nobuyuki Tanimura; Keisuke Kuromiya; Susumu Ishikawa; Mihoko Kajita; Masazumi Tada; Yukinari Haraoka; Yuki Akieda; Tohru Ishitani; Yoichiro Fujioka; Yusuke Ohba; Sohei Yamada; Yoichiroh Hosokawa; Yusuke Toyama; Takaaki Matsui; Yasuyuki Fujita

  Current biology : CB, 24 Feb. 2020, Peer-reviewed

  
• Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex

  Nargess Khalilgharibi; Jonathan Fouchard; Nina Asadipour; Ricardo Barrientos; Maria Duda; Alessandra Bonfanti; Amina Yonis; Andrew Harris; Payman Mosaffa; Yasuyuki Fujita; Alexandre Kabla; Yanlan Mao; Buzz Baum; José J Muñoz; Mark Miodownik; Guillaume Charras

  Nature Physics, Aug. 2019, Peer-reviewed

  
• Flower power as human cancer cells compete with normal cells.

  Fujita Y

  Nature, Aug. 2019, Peer-reviewed

  
• Epithelial defense against cancer (EDAC).

  Tanimura N; Fujita Y

  Seminars in cancer biology, Jul. 2019, Peer-reviewed

  
• Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.

  Miki Nishio; Yousuke Miyachi; Junji Otani; Shoji Tane; Hirofumi Omori; Fumihito Ueda; Hideru Togashi; Takehiko Sasaki; Tak Wah Mak; Kazuwa Nakao; Yasuyuki Fujita; Hiroshi Nishina; Tomohiko Maehama; Akira Suzuki

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Apr. 2019, Peer-reviewed

  
• Spontaneous Spatial Correlation of Elastic Modulus in Jammed Epithelial Monolayers Observed by AFM.

  Yuki Fujii; Yuki Ochi; Masahiro Tuchiya; Mihoko Kajita; Yasuyuki Fujita; Yukitaka Ishimoto; Takaharu Okajima

  Biophysical journal, 19 Mar. 2019, Peer-reviewed

  
• Ras activation in retinal progenitor cells induces tumor formation in the eye.

  Koso H; Tsuhako A; Matsubara D; Fujita Y; Watanabe S

  Experimental eye research, Mar. 2019, Peer-reviewed

  
• Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility.

  Søgaard PP; Ito N; Sato N; Fujita Y; Matter K; Itoh Y

  Life science alliance, Feb. 2019, Peer-reviewed

  
• Accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cells

  Mikio Takagi; Masaya Ikegawa; Takashi Shimada; Susumu Ishikawa; Mihoko Kajita; Takeshi Maruyama; Tomoko Kamasaki; Yasuyuki Fujita

  GENES TO CELLS, Nov. 2018, Peer-reviewed

  
• Src-transformed cells hijack mitosis to extrude from the epithelium.

  Anton KA; Kajita M; Narumi R; Fujita Y; Tada M

  Nature communications, Nov. 2018, Peer-reviewed

  
• Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.

  Hirotaka Watanabe; Kojiro Ishibashi; Hiroki Mano; Sho Kitamoto; Nanami Sato; Kazuya Hoshiba; Mugihiko Kato; Fumihiko Matsuzawa; Yasuto Takeuchi; Takanobu Shirai; Susumu Ishikawa; Yuka Morioka; Toshiaki Imagawa; Kazuyasu Sakaguchi; Suguru Yonezawa; Shunsuke Kon; Yasuyuki Fujita

  Cell reports, 26 Jun. 2018, Peer-reviewed

  
• ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells.

  Yako Y; Hayashi T; Takeuchi Y; Ishibashi K; Kasai N; Sato N; Kuromiya K; Ishikawa S; Fujita Y

  Scientific reports, Jun. 2018, Peer-reviewed

  
• The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation

  Nobuhiro Kasai; Ailijiang Kadeer; Mihoko Kajita; Sayaka Saitoh; Susumu Ishikawa; Takeshi Maruyama; Yasuyuki Fujita

  SCIENTIFIC REPORTS, Feb. 2018, Peer-reviewed

  
• The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation

  Nobuhiro Kasai; Ailijiang Kadeer; Mihoko Kajita; Sayaka Saitoh; Susumu Ishikawa; Takeshi Maruyama; Yasuyuki Fujita

  SCIENTIFIC REPORTS, Feb. 2018, Peer-reviewed

  
• Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

  Ayana Sasaki; Takahiro Nagatake; Riku Egami; Guoqiang Gu; Ichigaku Takigawa; Wataru Ikeda; Tomoya Nakatani; Jun Kunisawa; Yasuyuki Fujita

  Cell Reports, 2018, Peer-reviewed

  
• Local cellular neighborhood controls proliferation in cell competition

  Anna Bove; Daniel Gradeci; Yasuyuki Fujita; Shiladitya Banerjee; Guillaume Charras; Alan R. Lowe

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2017, Peer-reviewed

  
• Cell competition in mammals - novel homeostatic machinery for embryonic development and cancer prevention

  Takeshi Maruyama; Yasuyuki Fujita

  CURRENT OPINION IN CELL BIOLOGY, Oct. 2017, Peer-reviewed

  
• Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

  Shunsuke Kon; Kojiro Ishibashi; Hiroto Katoh; Sho Kitamoto; Takanobu Shirai; Shinya Tanaka; Mihoko Kajita; Susumu Ishikawa; Hajime Yamauchi; Yuta Yako; Tomoko Kamasaki; Tomohiro Matsumoto; Hirotaka Watanabe; Riku Egami; Ayana Sasaki; Atsuko Nishikawa; Ikumi Kameda; Takeshi Maruyama; Rika Narumi; Tomoko Morita; Yoshiteru Sasaki; Ryosuke Enoki; Sato Honma; Hiromi Imamura; Masanobu Oshima; Tomoyoshi Soga; Jun-ichi Miyazaki; Michael R. Duchen; Jin-Min Nam; Yasuhito Onodera; Shingo Yoshioka; Junichi Kikuta; Masaru Ishii; Masamichi Imajo; Eisuke Nishida; Yoichiro Fujioka; Yusuke Ohba; Toshiro Sato; Yasuyuki Fujita

  NATURE CELL BIOLOGY, May 2017, Peer-reviewed

  
• Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells

  Sayaka Saitoh; Takeshi Maruyama; Yuta Yako; Mihoko Kajita; Yoichiro Fujioka; Yusuke Ohba; Nobuhiro Kasai; Natsu Sugama; Shunsuke Kon; Susumu Ishikawa; Takashi Hayashi; Tomohiro Yamazaki; Masazumi Tada; Yasuyuki Fujita

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2017, Peer-reviewed

  
• Plectin is a novel regulator for apical extrusion of RasV12-transformed cells

  Ailijiang Kadeer; Takeshi Maruyama; Mihoko Kajita; Tomoko Morita; Ayana Sasaki; Atsuko Ohoka; Susumu Ishikawa; Masaya Ikegawa; Takashi Shimada; Yasuyuki Fujita

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

  
• EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors

  Sean Porazinski; Joaquin de Navascues; Yuta Yako; William Hill; Matthew Robert Jones; Robert Maddison; Yasuyuki Fujita; Catherine Hogan

  CURRENT BIOLOGY, Dec. 2016, Peer-reviewed

  
• MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status

  Takanori Chiba; Erika Ishihara; Norio Miyamura; Rika Narumi; Mihoko Kajita; Yasuyuki Fujita; Akira Suzuki; Yoshihiro Ogawa; Hiroshi Nishina

  SCIENTIFIC REPORTS, Jun. 2016, Peer-reviewed

  
• 【細胞競合の基本原理とその破綻】Ras変異細胞と正常上皮細胞間に生じる細胞競合

  釜崎 とも子; 藤田 恭之

  医学のあゆみ, Apr. 2016

  
• A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).

  Sayaka Yamamoto; Yuta Yako; Yoichiro Fujioka; Mihoko Kajita; Takeshi Kameyama; Shunsuke Kon; Susumu Ishikawa; Yusuke Ohba; Yusuke Ohno; Akio Kihara; Yasuyuki Fujita

  Molecular biology of the cell, 01 Feb. 2016, Peer-reviewed

  
• The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia

  Hajime Yamauchi; Takanori Matsumaru; Tomoko Morita; Susumu Ishikawa; Katsumi Maenaka; Ichigaku Takigawa; Kentaro Semba; Shunsuke Kon; Yasuyuki Fujita

  SCIENTIFIC REPORTS, Oct. 2015, Peer-reviewed

  
• EDAC: Epithelial defence against cancer-cell competition between normal and transformed epithelial cells in mammals

  Mihoko Kajita; Yasuyuki Fujita

  JOURNAL OF BIOCHEMISTRY, Jul. 2015, Peer-reviewed

  
• EPLIN is a crucial regulator for extrusion of RasV12-transformed cells

  Atsuko Ohoka; Mihoko Kajita; Junichi Ikenouchi; Yuta Yako; Sho Kitamoto; Shunsuke Kon; Masaya Ikegawa; Takashi Shimada; Susumu Ishikawa; Yasuyuki Fujita

  JOURNAL OF CELL SCIENCE, Feb. 2015, Peer-reviewed

  
• Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture

  Laura P. Ivers; Brendan Cummings; Funke Owolabi; Katarzyna Welzel; Rut Klinger; Sayaka Saitoh; Darran O'Connor; Yasuyuki Fujita; Dimitri Scholz; Nobue Itasaki

  CANCER CELL INTERNATIONAL, Oct. 2014, Peer-reviewed

  
• PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium

  Katarzyna A. Anton; John Sinclair; Atsuko Ohoka; Mihoko Kajita; Susumu Ishikawa; Peter M. Benz; Thomas Renne; Maria Balda; Claus Jorgensen; Karl Matter; Yasuyuki Fujita

  JOURNAL OF CELL SCIENCE, Aug. 2014, Peer-reviewed

  
• Filamin acts as a key regulator in epithelial defence against transformed cells

  Mihoko Kajita; Kaoru Sugimura; Atsuko Ohoka; Jemima Burden; Hitomi Suganuma; Masaya Ikegawa; Takashi Shimada; Tetsuya Kitamura; Masanobu Shindoh; Susumu Ishikawa; Sayaka Yamamoto; Sayaka Saitoh; Yuta Yako; Ryosuke Takahashi; Takaharu Okajima; Junichi Kikuta; Yumiko Maijima; Masaru Ishii; Masazumi Tada; Yasuyuki Fujita

  NATURE COMMUNICATIONS, Jul. 2014, Peer-reviewed

  
• Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours

  Dorothy Kuipers; Aida Mehonic; Mihoko Kajita; Loic Peter; Yasuyuki Fujita; Tom Duke; Guillaume Charras; Jonathan E. Gale

  JOURNAL OF CELL SCIENCE, Mar. 2014, Peer-reviewed

  
• 1SCA-03 Toward Understanding the Integration of Mechanical and Chemical Control of Epithelial Development and Maintenance(1SCA Beyond Biophysics!: Up-and-coming biophysical science achieved by physical, chemical and micromechanical control of a cell-sized space,Symposium,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Sugimura Kaoru; Kajita Mihoko; Fujita Yasuyuki; Ishihara Shuji

  Seibutsu Butsuri, 2014

  
• Spatiotemporal control of gene expression using microfluidics

  Alexandre Benedetto; Giovanni Accetta; Yasuyuki Fujita; Guillaume Charras

  LAB ON A CHIP, 2014, Peer-reviewed

  
• Basolateral BMP Signaling in Polarized Epithelial Cells

  Masao Saitoh; Takuya Shirakihara; Akira Fukasawa; Kana Horiguchi; Kei Sakamoto; Hiroshi Sugiya; Hideyuki Beppu; Yasuyuki Fujita; Ikuo Morita; Kohei Miyazono; Keiji Miyazawa

  PLOS ONE, May 2013, Peer-reviewed

  
• Competition between normal anc transformed epithelial cells-a novel dimension of cancer heterogeneity

  Kajita, M; Fujita, Y

  Jikkenigaku, Jan. 2013, Invited

  
• Epithelial self-defense against cancer

  Hajime Yamauchi; Yasuyuki Fujita

  CELL RESEARCH, Nov. 2012, Peer-reviewed

  
• [Interactions between normal and transformed epithelial cells: their clinical applications].

  Kajita M; Fujita Y

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Aug. 2012, Peer-reviewed

  
• Epithelial Homeostasis: Elimination by Live Cell Extrusion

  Hiroto Katoh; Yasuyuki Fujita

  CURRENT BIOLOGY, Jun. 2012, Peer-reviewed

  
• Loss of Scribble causes cell competition in mammalian cells

  Mark Norman; Katarzyna A. Wisniewska; Kate Lawrenson; Pablo Garcia-Miranda; Masazumi Tada; Mihoko Kajita; Hiroki Mano; Susumu Ishikawa; Masaya Ikegawa; Takashi Shimada; Yasuyuki Fujita

  JOURNAL OF CELL SCIENCE, Jan. 2012, Peer-reviewed

  
• Interface between normal and transformed epithelial cells: A road to a novel type of cancer prevention and treatment

  Yasuyuki Fujita

  CANCER SCIENCE, Oct. 2011, Peer-reviewed

  
• A Positive Role of Cadherin in Wnt/beta-Catenin Signalling during Epithelial-Mesenchymal Transition

  Sara Howard; Tom Deroo; Yasuyuki Fujita; Nobue Itasaki

  PLOS ONE, Aug. 2011, Peer-reviewed

  
• Interactions between normal and transformed epithelial cells: Their contributions to tumourigenesis

  Catherine Hogan; Mihoko Kajita; Kate Lawrenson; Yasuyuki Fujita

  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Apr. 2011, Peer-reviewed

  
• Interactions between normal and transformed epithelial cells

  Sophie Dupre-Crochet; Catherine Hogan; Yasuyuki Fujita

  M S-MEDECINE SCIENCES, May 2010, Peer-reviewed

  
• Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells

  Mihoko Kajita; Catherine Hogan; Andrew R. Harris; Sophie Dupre-Crochet; Nobue Itasaki; Koichi Kawakami; Guillaume Charras; Masazumi Tada; Yasuyuki Fujita

  JOURNAL OF CELL SCIENCE, Jan. 2010, Peer-reviewed

  
• [Interface between normal and transformed epithelial cells].

  Fujita Y; Kajita M

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jan. 2010, Peer-reviewed

  
• Hacking RNA Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF

  Angelica Figueroa; Yasuyuki Fujita; Myriam Gorospe

  CELL CYCLE, Nov. 2009, Peer-reviewed

  
• Novel Roles of Hakai in Cell Proliferation and Oncogenesis

  Angelica Figueroa; Hirokazu Kotani; Yoshinobu Toda; Krystyna Mazan-Mamczarz; Eva-Christina Mueller; Albrecht Otto; Lena Disch; Mark Norman; Rasika Mohan Ramdasi; Mohammed Keshtgar; Myriam Gorospe; Yasuyuki Fujita

  MOLECULAR BIOLOGY OF THE CELL, Aug. 2009, Peer-reviewed

  
• Characterization of the interface between normal and transformed epithelial cells

  Catherine Hogan; Sophie Dupre-Crochet; Mark Norman; Mihoko Kajita; Carola Zimmermann; Andrew E. Pelling; Eugenia Piddini; Luis Alberto Baena-Lopez; Jean-Paul Vincent; Yoshifumi Itoh; Hiroshi Hosoya; Franck Pichaud; Yasuyuki Fujita

  NATURE CELL BIOLOGY, Apr. 2009, Peer-reviewed

  
• [Interaction between normal and transformed epithelial cells].

  Kajita M; Fujita Y

  Seikagaku. The Journal of Japanese Biochemical Society, Apr. 2009, Peer-reviewed

  
• Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation

  Filipa Carreira-Barbosa; Mihiko Kajita; Veronique Morel; Hironori Wada; Hitoshi Okamoto; Alfonso Martinez Arias; Yasuyuki Fujita; Stephen W. Wilson; Masazumi Tada

  DEVELOPMENT, Feb. 2009, Peer-reviewed

  
• A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus

  Emma C. Ferber; Mihoko Kajita; Anthony Wadlow; Lara Tobiansky; Carien Niessen; Hiroyoshi Ariga; Juliet Daniel; Yasuyuki Fujita

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2008, Peer-reviewed

  
• p32 is a novel mammalian Lgl binding protein that enhances the activity of protein kinase C zeta and regulates cell polarity

  Carl U. Bialucha; Emma C. Ferber; Franck Pichaud; Sew Y. Peak-Chew; Yasuyuki Fujita

  JOURNAL OF CELL BIOLOGY, Aug. 2007, Peer-reviewed

  
• The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

  Catherine Rose Hosking; Fausto Ulloa; Catherine Hogan; Emma C. Ferber; Anglica Figueroa; Kris Gevaert; Walter Birchmeier; James Briscoe; Yasuyuki Fujita

  MOLECULAR BIOLOGY OF THE CELL, May 2007, Peer-reviewed

  
• Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts

  Sophie Dupre-Crochet; Angelica Figueroa; Catherine Hogan; Emma C. Ferber; Carl Uli Bialucha; Joanna Adams; Emily C. N. Richardson; Yasuyuki Fujita

  MOLECULAR AND CELLULAR BIOLOGY, May 2007, Peer-reviewed

  
• Regulated and polarized Ptdlns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells

  N Pinal; DCI Goberdhan; L Collinson; Y Fujita; IM Cox; C Wilson; F Pichaud

  CURRENT BIOLOGY, Jan. 2006, Peer-reviewed

  
• Regulation of cell-cell adhesion by Rap1

  Yasuyuki Fujita; Catherine Hogan; Vania M. M. Braga

  REGULATORS AND EFFECTORS OF SMALL GTPASES: RAS FAMILY, 2006, Peer-reviewed

  
• Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions

  F Palacios; JS Tushir; Y Fujita; C D'Souza-Schorey

  MOLECULAR AND CELLULAR BIOLOGY, Jan. 2005, Peer-reviewed

  
• Epithelial cell shape and Rho small GTPases.

  Fujita Y; Braga V

  Novartis Foundation symposium, 2005, Peer-reviewed

  
• Rap1 regulates the formation of E-cadherin-based cell-cell contacts

  C Hogan; N Serpente; P Cogram; CR Hosking; CU Bialucha; SM Feller; VMM Braga; W Birchmeier; Y Fujita

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 2004, Peer-reviewed

  
• A novel interaction between kinesin and p120 modulates p120 localization and function

  M Yanagisawa; IN Kaverina; AX Wang; Y Fujita; AB Reynolds; PZ Anastasiadis

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2004, Peer-reviewed

  
• beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

  D Zechner; Y Fujita; J Hulsken; T Muller; Walther, I; MM Taketo; EB Crenshaw; W Birchmeier; C Birchmeier

  DEVELOPMENTAL BIOLOGY, Jun. 2003, Peer-reviewed

  
• Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

  Y Fujita; G Krause; M Scheffner; D Zechner; HEM Leddy; J Behrens; T Sommer; W Birchmeier

  NATURE CELL BIOLOGY, Mar. 2002, Peer-reviewed

  
• Tomosyn: A syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process

  Yasuyuki Fujita; Hiromichi Shirataki; Toshiaki Sakisaka; Takeshi Asakura; Takeshi Ohya; Hirokazu Kotani; Shigekazu Yokoyama; Hideo Nishioka; Yoshiharu Matsuura; Akira Mizoguchi; Richard H. Scheller; Yoshimi Takai

  Neuron, May 1998

  
• Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: Its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin

  Yasuyuki Fujita; Takuya Sasaki; Koji Fukui; Hirokazu Kotani; Toshihiro Kimura; Yutaka Hata; Thomas C. Südhof; Richard H. Scheller; Yoshimi Takait

  Journal of Biological Chemistry, 29 Mar. 1996, Peer-reviewed

  
• GDP/GTP exchange reaction-stimulating activity of Rabphilin-3A for Rab3A small GTP-binding protein

  Yasuyuki Fujita; Takuya Sasaki; Keishi Araki; Kazuo Takahashi; Katsunori Imazumi; Masaki Kato; Yoshiharu Matsuura; Yoshimi Takai

  FEBS Letters, 10 Oct. 1994

  
• The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated

  Fujita Yasuyuki

  Peer-reviewed

  

Misc.

• Isolation of a novel syntaxin-binding protein from rat brain.

  Y Fujita; H Kotani; T Kimura; T Sasaki; Y Takai

  MOLECULAR BIOLOGY OF THE CELL, Dec. 1996

  
• Signal propagation in short-range extrudes abnormal cells from epithelial sheets in animals

  山田壮平; 別所康全; 藤田恭之; 細川陽一郎; 松井貴輝

  日本分子生物学会年会プログラム・要旨集(Web), 2021

  
• EDAC (epithelial defense against cancer)

  丸山 剛; 藤田 恭之

  生体の科学, Mar. 2016

  
• 細胞競合と補償的細胞成長による組織恒常性維持

  田守洋一郎; 藤田恭之

  生化学, 2019

  
• 細胞競合の基本原理とその破綻 Ras変異細胞と正常上皮細胞間に生じる細胞競合

  釜崎とも子; 藤田恭之

  医学のあゆみ, 2016

  
• Interactions between normal and transformed epithelial cells : their clinical applications

  KAJITA Mihoko; FUJITA Yasuyuki

  Folia Pharmacologica Japonica, 01 Aug. 2012

  
• Interface between normal and transformed epithelial cells: A road to a novel type of cancer prevention and treatment

  Yasuyuki Fujita

  Cancer Science, Oct. 2011

  
• 組織構築とがん化を制御する細胞競合の分子機構 マージャンによる細胞競合

  田守 洋一郎; 藤田 恭之; Deng Wu-Min

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• Involvement of Lgl and Mahjong/VprBP in Cell Competition

  Yoichiro Tamori; Carl Uli Bialucha; Ai-Guo Tian; Mihoko Kajita; Yi-Chun Huang; Mark Norman; Nicholas Harrison; John Poulton; Kenzo Ivanovitch; Lena Disch; Tao Liu; Wu-Min Deng; Yasuyuki Fujita

  PLOS BIOLOGY, Jul. 2010, Peer-reviewed

  
• マージャンによる細胞競合

  田守洋一郎; 藤田恭之; DENG Wu‐Min

  生化学, 2010

  
• Interaction between normal and transformed epithelial cells

  KAJITA Mihoko; FUJITA Yasuyuki

  生化學, 25 Apr. 2009

  
• Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation (vol 136, pg 383, 2009)

  Filipa Carreira-Barbosa; Mihoko Kajita; Veronique Morel; Hironori Wada; Hitoshi Okamoto; Alfonso Martinez Arias; Yasuyuki Fujita; Stephen W. Wilson; Masazumi Tada

  DEVELOPMENT, Mar. 2009

  
• Regulated and polarized Ptdins(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells (vol 16, pg 140, 2006)

  N Pinal; DCI Goberdhan; L Collinson; Y Fujita; IM Cox; C Wilson; F Pichaud

  CURRENT BIOLOGY, Feb. 2006

  
• 細胞内シグナル伝達 G蛋白質 Rab3Aと神経伝達物質の放出機構

  藤田恭之; 高井義美

  蛋白質 核酸 酵素, Feb. 1997

  
• 多段階発がんにおける細胞競合現象の勝者・敗者の入れ替わり

  小橋功紀; 鳴海利香; 釜崎とも子; 藤田恭之

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  

Awards

• 17 Apr. 2024

  科学技術分野の文部科学大臣表彰科学技術賞(研究部門)(令和6年度)
• 17 Apr. 2024

  科学技術分野の文部科学大臣表彰科学技術賞(研究部門)(令和6年度)
• 17 Apr. 2024

  令和６年度科学技術分野の文部科学大臣表彰科学技術賞

External funds: Kakenhi

• 細胞競合の普遍的制御分子の同定とその動作機序の解明

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  藤田 恭之

  From 10 Sep. 2021, To 31 Mar. 2026, Granted

  細胞競合;接触阻害;多細胞生命システムの自律性;synNotchシステム;空間オミクス解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05285/
• Elucidation of prevalent molecular mechanisms for cell competition

  Grant-in-Aid for Scientific Research (S)

  Broad Section G

  Kyoto University

  藤田 恭之

  From 05 Jul. 2021, To 31 Mar. 2026, Granted

  細胞競合

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H05039/
• Integrated understanding of intercellular communication and contraction forces

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University

  Yasuyuki Fujita

  From 30 Jul. 2020, To 31 Mar. 2022, Project Closed

  細胞競合;収縮力;牽引力顕微鏡;カルシウムスパーク;TRPC1;細胞内カルシウム;細胞間コミュニケーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21411/
• Elucidation of molecular mechanisms regulating cell competition and contact inhibition

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University;Hokkaido University

  Yasuyuki Fujita

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  接触阻害;上皮多層化;COL17A1;CD44;細胞競合;細胞間コミュニケーション;ファージ抗体ディスプレイスクリーニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03994/
• International netoworking on cell competition for the next generation

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Hokkaido University

  Yasuyuki Fujita

  From 06 Nov. 2015, To 31 Mar. 2019, Project Closed

  細胞競合

  https://kaken.nii.ac.jp/grant/KAKENHI-INTERNATIONAL-15K21757/
• Cell competition: a mechanism for survival of the fittest in the multi-cellular community

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  From 10 Jul. 2014, To 31 Mar. 2019

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-3605/
• Molecular mechanisms of EDAC (Epithelial Defense Against Cancer)

  Grant-in-Aid for Scientific Research (A)

  Hokkaido University

  Yasuyuki Fujita

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  細胞競合

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26250026/
• Molecular mechanisms of cell competition between normal and transformed cells

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Hokkaido University

  Yasuyuki Fujita

  From 10 Jul. 2014, To 31 Mar. 2019, Project Closed

  細胞競合

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-26114008/
• Cell competition: a mechanism for survival of the fittest in the multi-cellular community

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Hokkaido University

  Yasuyuki Fujita

  From 10 Jul. 2014, To 31 Mar. 2019, Project Closed

  細胞競合

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-26114001/
• 正常上皮細胞と癌細胞の相互作用ー新規な癌治療法の開発を目指してー

  Grant-in-Aid for Scientific Research (A)

  Hokkaido University

  藤田 恭之

  From 01 Apr. 2011, To 31 Mar. 2012, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23247032/
• 正常上皮細胞と癌細胞の相互作用

  Grant-in-Aid for Research Activity Start-up

  Hokkaido University

  藤田 恭之

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  癌;上皮細胞;Cell Cometition;細胞培養;新規癌治療法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22890002/
• Understanding multicellular autonomy by competitive cell-cell communications

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  井垣 達吏

  From 10 Sep. 2021, To 31 Mar. 2026, Granted

  細胞競合;多細胞生命システム;自律性;自己最適化;自己組織化

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-21H05283/

External funds: others

• 細胞競合の包括的理解を目指して (2022年度分)

  Japan Society for the Promotion of Science (JSPS), 二国間交流事業共同研究・セミナー

  From 01 Apr. 2022, To 31 Mar. 2023

  代表者
• 細胞競合の包括的理解を目指して (2021年度分)

  Japan Society for the Promotion of Science (JSPS), 二国間交流事業共同研究・セミナー

  From 01 Apr. 2021, To 31 Mar. 2022

  代表者

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamentals of Cell and Molecular Biology

  N486, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamentals of Cell and Molecular Biology

  N486, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamentals of Cell and Molecular Biology

  N486, Spring, Institute for Liberal Arts and Sciences, 2
• From Apr. 2020, To Mar. 2021

  Fundamentals of Cell and Molecular Biology

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Fundamentals of Cell and Molecular Biology

  Spring, 全学共通科目

Participation in PhD Defense

• Combination therapy with EGFR tyrosine kinase inhibitors and TEAD inhibitor increases tumor suppression effects in EGFR mutation-positive lung cancer

  OGIMOTO TATSUYA, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis

  MASUDA TOMONORI, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Ferroptosis-related Gene Glutathione Peroxidase 4 Promotes Reprogramming of Glucose Metabolism via Akt-mTOR Axis in Intrahepatic Cholangiocarcinoma

  HORI YUTARO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

  OMATSU MAYUKI, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway

  NAMIKAWA MIO, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice

  WEI Heng, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Extracellular vesicles secreted from bone metastatic renal cell carcinoma promote angiogenesis and endothelial gap formation in bone marrow in a time-dependent manner in a preclinical mouse model

  TAKEDA MASASHI, Graduate School of Medicine, Chief Examiner

  24 Jul. 2023
• Efficacious Combination Drug Treatment for Colorectal Cancer that Overcomes Resistance to KRAS G12C Inhibitors

  MATSUBARA HIROYUKI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Chlorambucil-conjugated PI-polyamides (Chb-M’), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation

  MATSUI YASUZUMI, Graduate School of Medicine, Chief Examiner

  23 May 2023
• Novel and efficient method for culturing patient-derived gastric cancer stem cells

  MORIMOTO TOMONORI, Graduate School of Medicine, Sub-chief Examiner

  25 Sep. 2023
• Bmal1 Regulates Prostate Growth via Cell-Cycle Modulation

  UEDA MASAKATSU, Graduate School of Medicine, Chief Examiner

  25 Sep. 2023
• Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation

  MARUI SAIKO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Inhibition of Dopamine Receptor D1 Signaling Promotes Human Bile Duct Cancer Progression via WNT signaling

  YOGO AKITADA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer

  UKITA MASAYO, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2

  MASUO KENJI, Graduate School of Medicine, Chief Examiner

  25 Jul. 2022
• Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice

  NAGAO MUNEMASA, Graduate School of Medicine, Chief Examiner

  24 Nov. 2022
• Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia

  UMEDA　MASAYUKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Brg1 is required to maintain colorectal cancer stem cells

  YOSHIKAWA TAKAAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Colorectal cancer-derived CAT1-positive extracellular vesicles alter nitric oxide metabolism in endothelial cells and promote angiogenesis

  IKEDA ATSUSHI, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains

  AKIFUJI CHIAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Epithelial expressions of Gata4 and Sox2 regulate specification of the squamous-columnar junction via MAPK/ERK signaling in mice

  SANKODA NAO, Graduate School of Medicine, Chief Examiner

  24 May 2021
• Trp53 Mutation in Keratin 5 (Krt5)-Expressing Basal Cells Facilitates the Development of Basal Squamous-Like Invasive Bladder Cancer in the Chemical Carcinogenesis of Mouse Bladder

  MASUDA NORIHIKO, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• Extracellular vesicles synchronize cellular phenotypes of differentiating cells

  MINAKAWA TOMOHIRO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations

  NIKAIDO MITSUHIRO, Graduate School of Medicine, Sub-chief Examiner

  24 Sep. 2021

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  大学院教育支援機構 大学院共通・横断教育企画評価専門委員会 研究科横断教育特別部会
• From 01 Apr. 2023

  大学院横断教育プログラム運営委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2024

  大学院教育支援機構 大学院共通・横断教育企画評価専門委員会 研究科横断教育特別部会 委員
• From 27 Dec. 2022, To 03 Feb. 2023

  国際卓越研究大学構想検討委員会　研究等体制強化計画検討タスクフォース　「学部教育の将来像」検討小委員会 委員

Faculty management (title, position)

• From 01 Oct. 2023, To 30 Sep. 2025

  関係病院人事連絡委員会_委員
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科・医学部将来計画検討委員会委員
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科・医学部国際交流委員会委員
• From 01 Oct. 2022, To 30 Sep. 2024

  京都大学医学研究科・医学部動物実験委員会
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科産学共同講座等検討委員会委員
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科・医学部財務委員会委員
• From 01 Oct. 2022, To 30 Sep. 2024

  医学研究科教員人事活性化委員会委員
• From 01 Oct. 2022, To 30 Sep. 2024

  部局業績評価委員会委員
• From 01 Apr. 2023, To 31 Mar. 2025

  医学図書館運営委員会委員
• From 01 Nov. 2022, To 31 Oct. 2024

  医学研究科期限付特定教員採用審査委員会委員
• From 01 Nov. 2022

  社会健康医学系専攻アドバイザリーボード委員
• From 01 Apr. 2020, To 31 Mar. 2022

  動物実験施設管理委員会
• From 01 Oct. 2020, To 30 Sep. 2021

  国際交流委員会委員
• From 01 Oct. 2020, To 30 Sep. 2022

  動物実験委員会委員
• From 01 Oct. 2020, To 30 Sep. 2022

  産学共同講座等検討委員会委員
• From 01 Nov. 2020, To 31 Oct. 2022

  期限付特定教員採用審査委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  医学研究科・医学部将来計画検討委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  入学者選抜方法検討委員会委員