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Shimoda, Asako
The HAKUBI Center for Advanced Research Program-Specific Assistant Professor
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Last Updated :2024/09/17
Research
Research Areas
Papers
- Surface Glycan Profiling of Extracellular Vesicles by Lectin Microarray and Glycoengineering for Control of Cellular InteractionsAsako Shimoda; Kazunari AkiyoshiPHARMACEUTICAL RESEARCH, Apr. 2023
- Classification of Extracellular Vesicles Based on Surface Glycan Structures by Spongy-like Separation Media.Eisuke Kanao; Shuntaro Wada; Hiroshi Nishida; Takuya Kubo; Tetsuya Tanigawa; Koshi Imami; Asako Shimoda; Kaori Umezaki; Yoshihiro Sasaki; Kazunari Akiyoshi; Jun Adachi; Koji Otsuka; Yasushi IshihamaAnalytical chemistry, 27 Dec. 2022
- CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinomaHaruki Odaka; Keiko Hiemori; Asako Shimoda; Kazunari Akiyoshi; Hiroaki TatenoBMC GASTROENTEROLOGY, Mar. 2022
- Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange methodNaohiro Seo; Junko Nakamura; Tsuguhiro Kaneda; Hiroaki Tateno; Asako Shimoda; Takanori Ichiki; Koichi Furukawa; Jun Hirabayashi; Kazunari Akiyoshi; Hiroshi ShikuJOURNAL OF EXTRACELLULAR VESICLES, Mar. 2022
- Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery ApplicationsAsako Shimoda; Risako Miura; Hiroaki Tateno; Naohiro Seo; Hiroshi Shiku; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari AkiyoshiSMALL METHODS, Feb. 2022
- New Lipophilic Fluorescent Dyes for Labeling Extracellular Vesicles: Characterization and Monitoring of Cellular UptakeTakashi Shimomura; Ryo Seino; Kaori Umezaki; Asako Shimoda; Takatoshi Ezoe; Munetaka Ishiyama; Kazunari AkiyoshiBIOCONJUGATE CHEMISTRY, Apr. 2021
- Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assaysHaruki Odaka; Keiko Hiemori; Asako Shimoda; Kazunari Akiyoshi; Hiroaki TatenoFEBS OPEN BIO, Mar. 2021
- Murine CD8+T cell EV that prevents tumor metastasis is classified into exosome of late endosome originNaohiro Seo; Junko Nakamura; Tsuguhiro Kaneda; Asako Shimoda; Kazunari Akiyoshi; Hiroshi ShikuCANCER SCIENCE, Feb. 2021
- Development of Lectin-immobilized Spongy Monoliths for Sub-classification of ExosomeTakuya Kubo; Seiya Kato; Asako Shimoda; Raga Ishikawa; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Koji OtsukaBUNSEKI KAGAKU, 2020
- Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array systemAsako Shimoda; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari AkiyoshiSCIENTIFIC REPORTS, Aug. 2019
- Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cellsAsako Shimoda; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari AkiyoshiBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2017
- Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagAAsako Shimoda; Koji Ueda; Shin Nishiumi; Naoko Murata-Kamiya; Sada-atsu Mukai; Shin-ichi Sawada; Takeshi Azuma; Masanori Hatakeyama; Kazunari AkiyoshiSCIENTIFIC REPORTS, Jan. 2016
- Nanogel containing electrospun nanofibers as a platform for stable loading of proteinsAsako Shimoda; Yong Chen; Kazunari AkiyoshiRSC ADVANCES, 2016
- Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption modelToshimi Sato; Neil Alles; Masud Khan; Kenichi Nagano; Mariko Takahashi; Yukihiko Tamura; Asako Shimoda; Keiichi Ohya; Kazunari Akiyoshi; Kazuhiro AokiINTERNATIONAL JOURNAL OF NANOMEDICINE, 2015
- Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release deliveryAsako Shimoda; Shin-ichi Sawada; Arihiro Kano; Atsushi Maruyama; Alexandre Moquin; Francoise M. Winnik; Kazunari AkiyoshiCOLLOIDS AND SURFACES B-BIOINTERFACES, Nov. 2012
- Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineeringMasako Fujioka-Kobayashi; Masato S. Ota; Asako Shimoda; Ken-ichi Nakahama; Kazunari Akiyoshi; Youji Miyamoto; Sachiko IsekiBIOMATERIALS, Oct. 2012
- Exploitation of a novel polysaccharide nanogel cross-linking membrane for guided bone regeneration (GBR)Takayuki Miyahara; Myat Nyan; Asako Shimoda; Yuka Yamamoto; Shinji Kuroda; Makoto Shiota; Kazunari Akiyoshi; Shohei KasugaiJOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Aug. 2012
- Biodegradable nanogel-integrated hydrogels for sustained protein deliveryAsako Shimoda; Yuka Yamamoto; Shin-ichi Sawada; Kazunari AkiyoshiMACROMOLECULAR RESEARCH, Mar. 2012
- The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-alpha-induced bone resorption lacunae on mouse calvariaeKenichi Nagano; Neil Alles; Anower Hussain Mian; Asako Shimoda; Nobuyuki Morimoto; Yukihiko Tamura; Hitoyata Shimokawa; Kazunari Akiyoshi; Keiichi Ohya; Kazuhiro AokiJOURNAL OF BONE AND MINERAL METABOLISM, Nov. 2011
- Cell Specific Peptide-Conjugated Polysaccharide Nanogels for Protein DeliveryAsako Shimoda; Shin-ichi Sawada; Kazunari AkiyoshiMACROMOLECULAR BIOSCIENCE, Jul. 2011
- Suppression of NF-kappa B Increases Bone Formation and Ameliorates Osteopenia in Ovariectomized MiceNeil Alles; Niroshani S. Soysa; Juri Hayashi; Masud Khan; Asako Shimoda; Hitoyata Shimokawa; Olaf Ritzeler; Kazunari Akiyoshi; Kazuhiro Aoki; Keiichi OhyaENDOCRINOLOGY, Oct. 2010
- The effects of anti-bone resorptive peptide with nanogel sheet as a peptide carrier: comparison to a nanogel cross-linking hydrogelKazuhiro Aoki; Neil Alles; Masud Kahn; Asako Shimoda; Kenichi Nagano; Kazunari Akiyoshi; Keiichi OhyaJOURNAL OF PHARMACOLOGICAL SCIENCES, 2010
- The control release of TNF-alpha is necessary to mimic the LPS-induced bone resorption on calvariaKenichi Nagano; Kazuhiro Aoki; Hussain Mian; Neil Alles; Asako Shimoda; Nobuyuki Morimoto; Kazunari Akiyoshi; Keiichi OhyaJOURNAL OF PHARMACOLOGICAL SCIENCES, 2009
Misc.
- Diversity analysis of exosomes by their glycan profiling for controlling cellular interactionsShimoda Asako; Tateno Hiroaki; Akiyoshi Kazunari生化学, 25 Apr. 2023
- エクソソームのサブクラス分離へ向けたレクチン固定化スポンジ基材の開発久保 拓也; 加藤 誠也; 下田 麻子; 石川 良賀; 澤田 晋一; 佐々木 善浩; 秋吉 一成; 大塚 浩二分析化学, Dec. 2020
- Glycomics of extracellular vesicles, exosomesShimoda Asako; Akiyoshi Kazunari生化学, 25 Jun. 2020, Peer-reviewed
- 【エクソソーム最前線】エクソソーム糖鎖とその機能下田 麻子; 秋吉 一成炎症と免疫, Jun. 2018
- エクソソームによる異種生物間のコミュニケーションと疾患—Cell-to-cell communications among different species by exosomes and their roles in diseases—特集 エクソソームと疾患 : そして臨床応用ヘ下田 麻子; 秋吉 一成細胞, Jan. 2016
- Development and Function of Exosomes as Bio–nanotransportersSawada Shinichi; Shimoda Asako; Sato Yuko; Seo Naohiro; Shiku Hiroshi; Akiyoshi KazunariMEMBRANE, 2015
- Characterization and Functional Modification of Extracellular VesiclesShimoda Asako; Sawada Shin-ichi; Akiyoshi KazunariDrug Delivery System, 2014
- 学会印象記 第26回日本DDS学会—Meeting report: 26th annual meeting of the Japan Society of Drug Delivery System山下 恵子; 下田 麻子; 安永 正浩Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System / 日本DDS学会 編, Jul. 2010
Books and Other Publications
- EVs : 細胞外小胞の生物学 : エクソソームをはじめとする多様な小胞の生理・病理の理解と新しい解析法中野, 明彦; 吉森, 保; 華山, 力成, 糖鎖解析による細胞外小胞の多様性と機能性評価羊土社, Dec. 2021
- AI・ナノ・量子による超高感度・迅速バイオセンシング : 超早期パンデミック検査・超早期診断・POCTから健康長寿社会へ馬場, 嘉信; 柳田, 剛; 加地, 範匡, 細胞外小胞による超早期がん診断シーエムシー出版, Aug. 2021
- 決定版エクソソーム実験ガイド : 世界に通用するプロトコールで高精度なデータを得る!吉岡, 祐亮; 落谷, 孝広, レクチンアレイによるエクソソーム表層糖鎖解析羊土社, Oct. 2020
- 医療を変えるエクソソーム : 生体機能から疾患メカニズム、臨床応用まで落谷, 孝広; 吉岡, 祐亮, 細菌が分泌するエクソソーム化学同人, Aug. 2018
- 炎症と免疫 2018年7月号 (Vol.26 No.4)宮坂 信之, エクソソーム糖鎖とその機能先端医学社, Jul. 2018
- パラダイムシフトをもたらすエクソソーム機能研究最前線 : シグナル伝達からがん、免疫、神経疾患との関わり、創薬利用まで落谷, 孝広, エクソソームによるピロリ菌病原タンパク質の輸送エヌ・ティー・エス, Mar. 2017
- 先端バイオマテリアルハンドブック秋吉, 一成; 石原, 一彦 ( 工学); 山岡, 哲ニ, 再生医療のためのナノゲル基盤ヒドロゲルエヌ・ティー・エス, Jun. 2012
- ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術田畑, 泰彦, インジェクタブル高分子メディカルドゥ, Aug. 2009
External funds: Kakenhi
- 骨芽細胞由来細胞外小胞の糖鎖による分類と細胞応答Grant-in-Aid for Scientific Research (C)Basic Section 90120:Biomaterials-relatedKyoto University下田 麻子From 01 Apr. 2020, To 31 Mar. 2024, Granted細胞外小胞;糖鎖解析;レクチンマイクロアレイ;基質小胞;糖鎖;レクチンアレイ
- Elucidation of the interaction of exosome surface glycans and target cellsGrant-in-Aid for Young Scientists (B)Kyoto UniversityAsako ShimodaFrom 01 Apr. 2017, To 31 Mar. 2019, Project Closed細胞外微粒子;エクソソーム;糖鎖;レクチンアレイ
- MSC exosome-polysaccharide nanogel hybrid for bone regenerationGrant-in-Aid for Young Scientists (B)Kyoto UniversityAsako ShimodaFrom 01 Apr. 2015, To 31 Mar. 2017, Project Closedエクソソーム;マトリックスベシクル;間葉系幹細胞;骨再生;糖鎖;生体材料
- Analysis on the possibility of various tissue regeneration with the Nanogel possesing a molecular chaperone functionGrant-in-Aid for Research Activity Start-upTokyo Medical and Dental UniversityTakayuki MiyaharaFrom 29 Aug. 2014, To 31 Mar. 2016, Project Closed骨再生;GBR;Nanogel;membrane;collagen;nano gel;再生医療;メンブレン;軟組織再生;硬組織再生;ドラッグデリバリーシステム(DDS);ナノキャリアー;分子シャペロン機能;骨組織再生;神経組織再生;Guided Bone Regeneration;国際情報交換
