Basic Information

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  201401071137439690

researchmap URL

• https://researchmap.jp/7000008832

Research

Research Topics, Overview of the research

• Research Topics

  1. Orderly differentiation system from human pluripotent stem cells (PSCs) towards mesodermal cells and various lineages of blood cells, and induction of PSC-derived hematopoietic stem cells
  
  2. Identification of Functional characters and importance of an extracellular matrix Laminin 411 during vascular endothelial differentiation, and increase in efficacy and purity of iPSC-derived endothelial differentiation.
  
  3. Elucidation of the pathology and discovery of novel therapeutic methods of intractable hematological/immunological diseases through PSC-based disease modeling.
  
  4. Exploration of the pathology and discovery of novel therapy of hematological malignancy by combining in vivo and in vitro disease models

• Overview of the research

  1. Orderly differentiation system from human pluripotent stem cells (PSCs) towards mesodermal cells and various lineages of blood cells, and induction of PSC-derived hematopoietic stem cells
  
  Discovered PET-based collagen sponges allow longer culture times of PSC-derived hematopoietic stem/progenitor cells, leading to increase in the number of them.
  
  Established a novel serum-free monolayer culture that can trace the in vivo hematopoietic pathway from ES/iPS cells to functional definitive blood cells via mesodermal progenitors. Further improved, it has been used in all projects in our laboratory to elucidate the pathologies of various diseases through PSC-based disease model.
  
  2. Identification of Functional characters and importance of an extracellular matrix Laminin 411 during vascular endothelial differentiation, and increase in efficacy and purity of iPSC-derived endothelial differentiation.
  
  Discovered LM411, a minor extracellular matrix located around blood vessels, is effective at specifying the lineage towards endothelial cells from mesoderm. Furthermore, single-cell RNA-seq study revealed that Rho signals bridge between downstream of LM411 and a common endothelial growth hormone VEGF at the specific stage of differentiation to endothelial cells.
  
  
  3. Elucidation of the pathology and discovery of novel therapeutic methods of intractable hematological/immunological diseases through PSC-based disease modeling.
  
  As a part of AMED Research Center Network for Realization of Regenerative Medicine, drove the studies to explore the pathophysiology of intractable hematological/immunological diseases including Blau syndrome, CINCA syndrome, Fanconi anemia and Severe congenital neutropenia. Contribution: designing experiments, analyzing and preparing data and writing texts.
  
  
  4. Exploration of the pathology and discovery of novel therapy of hematological malignancy by combining in vivo and in vitro disease models
  
  In collaboration with division of Pediatrics, Kyoto University, established the in vivo model of leukemia with poor prognosis to elucidate the pathophysiology especially in extramedullary sites such as liver and central nervous system, leading to discover the niche-like histology and identify the mechanisms in adaptation of leukemic cells in those organs.

Research Areas

• Life sciences, Hematology and oncology

Papers

• Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors (Scientific Reports, (2020), 10, 1, (14859), 10.1038/s41598-020-71844-8)

  Takayuki Hamabata; Katsutsugu Umeda; Kagehiro Kouzuki; Takayuki Tanaka; Tomoo Daifu; Seishiro Nodomi; Satoshi Saida; Itaru Kato; Shiro Baba; Hidefumi Hiramatsu; Mitsujiro Osawa; Akira Niwa; Megumu K. Saito; Yasuhiko Kamikubo; Souichi Adachi; Yoshiko Hashii; Akira Shimada; Hiroyoshi Watanabe; Kenji Osafune; Keisuke Okita; Tatsutoshi Nakahata; Kenichiro Watanabe; Junko Takita; Toshio Heike

  Scientific Reports, 01 Dec. 2021

  
• Erratum: Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity (PLoS ONE (2020) 15:8 (e0237030) DOI: 10.1371/journal.pone.0237030)

  Ryosuke Seki; Akira Ohta; Akira Niwa; Yoshinori Sugimine; Haruna Naito; Tatsutoshi Nakahata; Megumu K. Saito

  PLoS ONE, 01 Apr. 2021

  
• A disease-specific iPS cell resource for studying rare and intractable diseases

  Megumu K. Saito; Mitsujiro Osawa; Nao Tsuchida; Kotaro Shiraishi; Akira Niwa; Knut Woltjen; Isao Asaka; Katsuhisa Ogata; Suminobu Ito; Shuzo Kobayashi; Shinya Yamanaka

  Inflammation and Regeneration, 08 Sep. 2023

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• UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models.

  Jingxin Wang; Norikazu Saiki; Ayako Tanimura; Takafumi Noma; Akira Niwa; Tastutoshi Nakahata; Megumu K Saito

  Biochemical and biophysical research communications, 20 Dec. 2023

  
• Angiocrine factors from HUVECs amplify erythroid cells

  Ryohichi Sugimura; Ryo Ohta; Chihiro Mori; Emi Sano; Tatsuki Sugiyama; Takashi Nagasawa; Akira Niwa; Yu-suke Torisawa; Megumu K. Saito

  11 Nov. 2019

  
• A concise in vitro model for evaluating interactions between macrophage and skeletal muscle cells during muscle regeneration

  Naoya Kase; Yohko Kitagawa; Akihiro Ikenaka; Akira Niwa; Megumu K. Saito

  Frontiers in Cell and Developmental Biology, 18 May 2023

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• SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

  Akihiro Ikenaka; Yohko Kitagawa; Michiko Yoshida; Chuang-Yu Lin; Akira Niwa; Tatsutoshi Nakahata; Megumu K Saito

  Life science alliance, Mar. 2023

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• Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy.

  Takahiro Hayashi; Naoko Yano; Kengo Kora; Atsushi Yokoyama; Kanako Maizuru; Taisei Kayaki; Kinuko Nishikawa; Mitsujiro Osawa; Akira Niwa; Toshiki Takenouchi; Atsushi Hijikata; Tsuyoshi Shirai; Hisato Suzuki; Kenjiro Kosaki; Megumu K Saito; Junko Takita; Takeshi Yoshida

  Human molecular genetics, 16 Jan. 2023

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• Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/gamma c (Null) Mouse

  Kato, Itaru; Niwa, Akira; Saito, Megumu; Fujino, Hisanori; Saida, Satoshi; Hiramatsu, Hidefumi; Oshima, Koichi; Ito, Mamoru; Adachi, Souichi; Heike, Toshio; Nakahata, Tatsutoshi

  BLOOD, 19 Nov. 2010, Peer-reviewed

  
• iPS cells from Chediak-Higashi syndrome patients recapitulate the giant granules in myeloid cells.

  Shigeharu Oh; Akira Niwa; Ayako Nagahashi; Isao Asaka; Tatsutoshi Nakahata; Megumu K Saito

  Pediatrics international : official journal of the Japan Pediatric Society, 19 Oct. 2022

  
• Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs.

  Hirotsugu Maekawa; Yonghui Jin; Megumi Nishio; Shunsuke Kawai; Sanae Nagata; Takeshi Kamakura; Hiroyuki Yoshitomi; Akira Niwa; Megumu K Saito; Shuichi Matsuda; Junya Toguchida

  Orphanet journal of rare diseases, 21 Sep. 2022

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• Serological and clinical studies on an epidemic of influenza type B.

  Niwa Akira

  Journal of Nippon Medical School, 1985

  
• Blockage of SDF-1-CXCR4 Axis by AMD 3100 Can Be a Novel Therapy for Acute Lymphoblastic Leukemia by Targeting the Extramedullary Sites of Leukemic Cells

  Kato Itaru; Niwa Akira; Fujino Hisanori; Umeda Katsutsugu; Saida Satoshi; Adachi Souichi; Ito Mamoru; Heike Toshio; Nakahata Tatsutoshi

  BLOOD, 20 Nov. 2009, Peer-reviewed

  
• iPSC-Based Phenomic Screen Revealed an Impact of Uncontrolled NFkB Activity at the Initiating Stages of AML1-ETO Related Leukemia

  Niwa Akira; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 29 Nov. 2018, Peer-reviewed

  
• NK Cells from Human Pluripotent Stem Cells for Immunotherapy

  Maysubara Hiroyuki; Niwa Akira; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 29 Nov. 2018, Peer-reviewed

  
• Exogenously Added Cofilin Increases Ex Vivo Production of Functional Platelets By Stimulating Proplatelet Formation

  Haruyama Munetada; Niwa Akira; Saito Megumu K; Nakahata Tatsutoshi

  BLOOD, 07 Dec. 2017, Peer-reviewed

  
• Identification of Candidate Progenitor Populations Which Causes Transient Abnormal Myelopoiesis

  Nishinaka-Arai Yoko; Niwa Akira; Matsuo Shiori; Kazuki Yasuhiro; Yakura Yuwna; Oshimura Mitsuo; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 07 Dec. 2017, Peer-reviewed

  
• VEGFA- a New Therapeutic Target in CNS Leukemia

  Itaru Kato; Yoko Nishinaka-Arai; Masahiro Nakamura; Ayse U. Akarca; Akira Niwa; Hiroki Ozawa; Kenichi Yoshida; Makiko Mori; Dapeng Wang; Hiroo Ueno; Yusuke Shiozawa; Yuichi Shiraishi; Satoru Miyano; Rajeev Gupta; Katsutsugu Umeda; Kenichiro Watanabe; Katsuyoshi Koh; Souichi Adachi; Toshio Heike; Megumu K. Saito; Masashi Sanada; Seishi Ogawa; Teresa Marafioti; Akira Watanabe; Tatsutoshi Nakahata; Tariq Enver

  BLOOD, Dec. 2016, Peer-reviewed

  
• Induction of Natural Killer Cells from Human Pluripotent Stem Cells Under Chemically Defined Condition

  Hiroyuki Matsubara; Akira Niwa; Tatsutoshi Nakahata; Megumu K. Saito

  BLOOD, Dec. 2016, Peer-reviewed

  
• Hepatoma-Derived Growth Factor Is a Novel Factor to Promote the Proliferation of Hematopoietic Stem Cells

  Munetada Haruyama; Kozo Yamaichi; Akira Niwa; Megumu K. Saito; Tatsutoshi Nakahata

  BLOOD, Dec. 2016, Peer-reviewed

  
• PSC-Derived Hematopoietic System to Elucidate the Cooperation Between Gene Alterations and Cell Lineages in Leukemogenesis

  Akira Niwa; Megumu K. Saito; Tatsutoshi Nakahata

  BLOOD, Dec. 2016, Peer-reviewed

  
• Exploring the Pathogenesis of Down Syndrome-Related Myeloproliferative Disorders Using iPSCs

  Nishinaka Yoko; Akira Niwa; Mitsujiro Osawa; Akira Watanabe; Tatsutoshi Nakahata; Megumu K. Saito

  BLOOD, Dec. 2014, Peer-reviewed

  
• Reduced Production of Mature Neutrophils From Induced Pluripotent Stem Cells Derived From a Severe Congenital Neutropenia Patient with HAX1 Gene Deficiency

  Tatsuya Morishima; Ken-ichiro Watanabe; Akira Niwa; Takayuki Tanaka; Katsutsugu Umeda; Hidefumi Hiramatsu; Kousaku Matsubara; Souichi Adachi; Tatsutoshi Nakahata; Toshio Heike

  BLOOD, Nov. 2011, Peer-reviewed

  
• Induction of Human Natural Killer Cells Under Defined Conditions by Seamless Transition from Maintenance Culture of Pluripotent Stem Cells.

  Akira Niwa; Megumu K Saito

  Methods in molecular biology (Clifton, N.J.), 2022

  
• PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Ph+ Leukemia with T315I Mutation in Bcr-Abl; In Vivo Analysis Using Xenograft Mice Model

  Saida Satoshi; Kato Itaru; Inukai Takeshi; Nemoto Atsushi; Sugita Kanji; Maeda Yasuhiro; Niwa Akira; Watanabe Ken-ichiro; Nakahata Tatsutoshi; Heike Toshio

  BLOOD, 18 Nov. 2011, Peer-reviewed

  
• iPS細胞由来エリスロポエチン産生細胞を用いた腎性貧血に対する細胞療法開発

  人見 浩史; 笠原 朋子; 片桐 直子; 保科 あずさ; 前 伸一; 小高 真希; 豊原 敬文; Rahman Asadur; 中野 大介; 丹羽 明; 齋藤 潤; 中畑 龍俊; 西山 成; 長船 健二

  日本腎臓学会誌, Apr. 2018

  
• Analyzing the Stepwise Developmental Pathway From ES/IPS Cells to Functional Mature Erythrocytes

  Niwa Akira; Fukatsu Tomoki; Umeda Katsutsugu; Kato Itaru; Sakai Hiromi; Morishima Tatsuya; Okita Keisuke; Yamanaka Shinya; Heike Toshio; Nakahata Tatsutoshi

  BLOOD, 20 Nov. 2009, Peer-reviewed

  
• Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification

  Matsuo S; Nishinaka-Arai Y; Kazuki Y; Oshimura M; Nakahata T; Niwa A; Megumu K. Saito

  PloS One, 29 Mar. 2021, Peer-reviewed, Corresponding author

  
• Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.

  Anfeng Mu; Asuka Hira; Akira Niwa; Mitsujiro Osawa; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Kazuko Inoue; Keita Kondo; Masato T Kanemaki; Tomonari Matsuda; Etsuro Ito; Seiji Kojima; Tatsutoshi Nakahata; Seishi Ogawa; Keigo Tanaka; Keitaro Matsuo; Megumu K Saito; Minoru Takata

  Blood, 12 Jan. 2021

  
• Bidirectional myofiber transition through altering the photobiomodulation condition.

  Chuang-Yu Lin; Akira Niwa; Chun-Yin Hou; Chung-Min Tsai; Hsi Chang

  Journal of photochemistry and photobiology. B, Biology, Nov. 2020

  
• Pluripotent stem cell-based screening identifies CUDC-907 as an effective compound for restoring the in vitro phenotype of Nakajo-Nishimura syndrome.

  Naoya Kase; Madoka Terashima; Akira Ohta; Akira Niwa; Fumiko Honda-Ozaki; Yuri Kawasaki; Tatsutoshi Nakahata; Nobuo Kanazawa; Megumu K Saito

  Stem cells translational medicine, 14 Oct. 2020

  
• Pluripotent stem cell model of Shwachman-Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors.

  Takayuki Hamabata; Katsutsugu Umeda; Kagehiro Kouzuki; Takayuki Tanaka; Tomoo Daifu; Seishiro Nodomi; Satoshi Saida; Itaru Kato; Shiro Baba; Hidefumi Hiramatsu; Mitsujiro Osawa; Akira Niwa; Megumu K Saito; Yasuhiko Kamikubo; Souichi Adachi; Yoshiko Hashii; Akira Shimada; Hiroyoshi Watanabe; Kenji Osafune; Keisuke Okita; Tatsutoshi Nakahata; Kenichiro Watanabe; Junko Takita; Toshio Heike

  Scientific reports, 09 Sep. 2020

  
• Biomimetic aorta-gonad-Mesonephros-on-a-Chip to study human developmental hematopoiesis.

  Ryohichi Sugimura; Ryo Ohta; Chihiro Mori; Alina Li; Takafumi Mano; Emi Sano; Kaori Kosugi; Tatsutoshi Nakahata; Akira Niwa; Megumu K Saito; Yu-Suke Torisawa

  Biomedical microdevices, 06 May 2020, Peer-reviewed

  
• Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.

  Yoko Nishinaka-Arai; Akira Niwa; Shiori Matsuo; Yasuhiro Kazuki; Yuwna Yakura; Takehiko Hiroma; Tsutomu Toki; Tetsushi Sakuma; Takashi Yamamoto; Etsuro Ito; Mitsuo Oshimura; Tatsutoshi Nakahata; Megumu K Saito

  Haematologica, 30 Apr. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity.

  Ryosuke Seki; Akira Ohta; Akira Niwa; Yoshinori Sugimine; Haruna Naito; Tatsutoshi Nakahata; Megumu K Saito

  PloS one, 2020

  
• Induction of human pluripotent stem cell-derived natural killer cells for immunotherapy under chemically defined conditions.

  Hiroyuki Matsubara; Akira Niwa; Tatsutoshi Nakahata; Megumu K Saito

  Biochemical and biophysical research communications, 12 Jul. 2019, Peer-reviewed, Corresponding author

  
• Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition.

  Ryo Ohta; Ryohichi Sugimura; Akira Niwa; Megumu K Saito

  Journal of visualized experiments : JoVE, 16 Jun. 2019, Peer-reviewed

  
• Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.

  Kazuki Taoka; Shunya Arai; Keisuke Kataoka; Masataka Hosoi; Masashi Miyauchi; Sho Yamazaki; Akira Honda; Wei Aixinjueluo; Takashi Kobayashi; Keiki Kumano; Akihide Yoshimi; Makoto Otsu; Akira Niwa; Tatsutoshi Nakahata; Hiromitsu Nakauchi; Mineo Kurokawa

  Scientific reports, 26 Oct. 2018, Peer-reviewed

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• Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.

  Hiroaki Ono; Ryo Ohta; Yuri Kawasaki; Akira Niwa; Hidetoshi Takada; Tatsutoshi Nakahata; Shouichi Ohga; Megumu K Saito

  Inflammation research : official journal of the European Histamine Research Society ... [et al.], Oct. 2018, Peer-reviewed

  
• Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress.

  Fumiko Honda-Ozaki; Madoka Terashima; Akira Niwa; Norikazu Saiki; Yuri Kawasaki; Haruna Ito; Akitsu Hotta; Ayako Nagahashi; Koichi Igura; Isao Asaka; Hongmei Lisa Li; Masakatsu Yanagimachi; Fukumi Furukawa; Nobuo Kanazawa; Tatsutoshi Nakahata; Megumu K Saito

  Stem cell reports, 05 Jun. 2018, Peer-reviewed

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• Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.

  Koichi Oshima; Norikazu Saiki; Michihiro Tanaka; Hiromi Imamura; Akira Niwa; Ayako Tanimura; Ayako Nagahashi; Akiyoshi Hirayama; Keisuke Okita; Akitsu Hotta; Shuichi Kitayama; Mitsujiro Osawa; Shin Kaneko; Akira Watanabe; Isao Asaka; Wataru Fujibuchi; Kohsuke Imai; Hiromasa Yabe; Yoshiro Kamachi; Junichi Hara; Seiji Kojima; Masaru Tomita; Tomoyoshi Soga; Takafumi Noma; Shigeaki Nonoyama; Tatsutoshi Nakahata; Megumu K Saito

  Biochemical and biophysical research communications, 04 Mar. 2018, Peer-reviewed

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• Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.

  Sanami Takada; Naotomo Kambe; Yuri Kawasaki; Akira Niwa; Fumiko Honda-Ozaki; Kazuki Kobayashi; Mitsujiro Osawa; Ayako Nagahashi; Katsunori Semi; Akitsu Hotta; Isao Asaka; Yasuhiro Yamada; Ryuta Nishikomori; Toshio Heike; Hiroyuki Matsue; Tatsutoshi Nakahata; Megumu K Saito

  The Journal of allergy and clinical immunology, Jan. 2018, Peer-reviewed

  
• Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice.

  Hirofumi Hitomi; Tomoko Kasahara; Naoko Katagiri; Azusa Hoshina; Shin-Ichi Mae; Maki Kotaka; Takafumi Toyohara; Asadur Rahman; Daisuke Nakano; Akira Niwa; Megumu K Saito; Tatsutoshi Nakahata; Akira Nishiyama; Kenji Osafune

  Science translational medicine, 27 Sep. 2017, Peer-reviewed

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• Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.

  Itaru Kato; Yoko Nishinaka; Masahiro Nakamura; Ayse U Akarca; Akira Niwa; Hiroki Ozawa; Kenichi Yoshida; Makiko Mori; Dapeng Wang; Makiko Morita; Hiroo Ueno; Yusuke Shiozawa; Yuichi Shiraishi; Satoru Miyano; Rajeev Gupta; Katsutsugu Umeda; Kenichiro Watanabe; Katsuyoshi Koh; Souichi Adachi; Toshio Heike; Megumu K Saito; Masashi Sanada; Seishi Ogawa; Teresa Marafioti; Akira Watanabe; Tatsutoshi Nakahata; Tariq Enver

  Blood, 08 Jun. 2017, Peer-reviewed

  
• Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.

  Yuri Kawasaki; Hirotsugu Oda; Jun Ito; Akira Niwa; Takayuki Tanaka; Atsushi Hijikata; Ryosuke Seki; Ayako Nagahashi; Mitsujiro Osawa; Isao Asaka; Akira Watanabe; Shigeo Nishimata; Tsuyoshi Shirai; Hisashi Kawashima; Osamu Ohara; Tatsutoshi Nakahata; Ryuta Nishikomori; Toshio Heike; Megumu K Saito

  Arthritis & rheumatology (Hoboken, N.J.), Feb. 2017, Peer-reviewed

  
• A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges.

  Yoshinori Sugimine; Akira Niwa; Hiroyuki Matsubara; Kazuki Kobayashi; Yasuhiko Tabata; Toshio Heike; Tatsutoshi Nakahata; Megumu K Saito

  International journal of hematology, Dec. 2016, Peer-reviewed

  
• Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.

  Ryo Ohta; Akira Niwa; Yukimasa Taniguchi; Naoya M Suzuki; Junko Toga; Emiko Yagi; Norikazu Saiki; Yoko Nishinaka-Arai; Chihiro Okada; Akira Watanabe; Tatsutoshi Nakahata; Kiyotoshi Sekiguchi; Megumu K Saito

  Scientific reports, 02 Nov. 2016, Peer-reviewed

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• Hematological disorders

  Megumu K. Saito; Akira Niwa

  Human iPS Cells in Disease Modelling, 01 Jan. 2016, Peer-reviewed

  
• Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.

  Atsushi Nemoto; Satoshi Saida; Itaru Kato; Jiro Kikuchi; Yusuke Furukawa; Yasuhiro Maeda; Koshi Akahane; Hiroko Honna-Oshiro; Kumiko Goi; Keiko Kagami; Shinya Kimura; Yuko Sato; Seiichi Okabe; Akira Niwa; Kenichiro Watanabe; Tatsutoshi Nakahata; Toshio Heike; Kanji Sugita; Takeshi Inukai

  Molecular cancer therapeutics, Jan. 2016, Peer-reviewed

  
• 患者由来iPS細胞を用いたcancer genomics情報に基づく新規治療法創出

  中村 英二郎; 室伏 善照; 木我 敬太; 今村 恵子; 杉山 愛子; 木下 和生; 大澤 光次郎; 丹羽 明; 斎藤 潤; 柴崎 昇; 神波 大己; 井上 治久; 小川 修

  日本癌学会総会記事, Oct. 2015

  
• Prognostic significance of aminopeptidase-N (CD13) in hepatoblastoma.

  Satoshi Saida; Ken-ichiro Watanabe; Itaru Kato; Hisanori Fujino; Katsutsugu Umeda; Shinya Okamoto; Shinji Uemoto; Tomoro Hishiki; Hideo Yoshida; Shiro Tanaka; Souichi Adachi; Akira Niwa; Tatsutoshi Nakahata; Toshio Heike

  Pediatrics international : official journal of the Japan Pediatric Society, Aug. 2015, Peer-reviewed

  
• Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.

  Naoya M Suzuki; Akira Niwa; Miharu Yabe; Asuka Hira; Chihiro Okada; Naoki Amano; Akira Watanabe; Ken-Ichiro Watanabe; Toshio Heike; Minoru Takata; Tatsutoshi Nakahata; Megumu K Saito

  Stem cells translational medicine, Apr. 2015, Peer-reviewed

  
• Phenomic Screen in Vivo and in Vitro to Explore Novel Pathogenesis of AML1-ETO-Positive Leukemia Using PSC-Derived Hematopoietic Cells

  Akira Niwa; Akitsu Hotta; Megumu K Saito; Tatsutoshi Nakahata

  Blood, 06 Dec. 2014

  
• Unique multipotent cells in adult human mesenchymal cell populations (vol 107, pg 8639, 2014)

  Kuroda Yasumasa; Kitada Masaaki; Wakao Shohei; Nishikawa Kouki; Tanimura Yukihiro; Makinoshima Hideki; Goda Makoto; Akashi Hideo; Inutsuka Ayumu; Niwa Akira; Shigemoto Taeko; Nabeshima Yoko; Nakahata Tatsutoshi; Nabeshima Yo-ichi; Fujiyoshi Yoshinori; Dezawa Mari

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 03 Jun. 2014, Peer-reviewed

  
• Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.

  Tatsuya Morishima; Ken-ichiro Watanabe; Akira Niwa; Hideyo Hirai; Satoshi Saida; Takayuki Tanaka; Itaru Kato; Katsutsugu Umeda; Hidefumi Hiramatsu; Megumu K Saito; Kousaku Matsubara; Souichi Adachi; Masao Kobayashi; Tatsutoshi Nakahata; Toshio Heike

  Haematologica, Jan. 2014, Peer-reviewed

  
• Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.

  Takayuki Sato; Toshio Kitawaki; Haruyuki Fujita; Makoto Iwata; Tomonori Iyoda; Kayo Inaba; Toshiaki Ohteki; Suguru Hasegawa; Kenji Kawada; Yoshiharu Sakai; Hiroki Ikeuchi; Hiroshi Nakase; Akira Niwa; Akifumi Takaori-Kondo; Norimitsu Kadowaki

  Journal of immunology (Baltimore, Md. : 1950), 15 Sep. 2013, Peer-reviewed

  
• Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions.

  Masakatsu D Yanagimachi; Akira Niwa; Takayuki Tanaka; Fumiko Honda-Ozaki; Seiko Nishimoto; Yuuki Murata; Takahiro Yasumi; Jun Ito; Shota Tomida; Koichi Oshima; Isao Asaka; Hiroaki Goto; Toshio Heike; Tatsutoshi Nakahata; Megumu K Saito

  PloS one, 2013, Peer-reviewed

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• Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.

  Takayuki Tanaka; Kazutoshi Takahashi; Mayu Yamane; Shota Tomida; Saori Nakamura; Koichi Oshima; Akira Niwa; Ryuta Nishikomori; Naotomo Kambe; Hideki Hara; Masao Mitsuyama; Nobuhiro Morone; John E Heuser; Takuya Yamamoto; Akira Watanabe; Aiko Sato-Otsubo; Seishi Ogawa; Isao Asaka; Toshio Heike; Shinya Yamanaka; Tatsutoshi Nakahata; Megumu K Saito

  Blood, 09 Aug. 2012, Peer-reviewed

  
• Disease-associated iPS cell lines representing hematological and immunological disorders

  SAITO Megumu K; NIWA Akira

  Inflamm Regen (Web), 2012, Peer-reviewed

  
• Morphologic and gene expression criteria for identifying human induced pluripotent stem cells.

  Shohei Wakao; Masaaki Kitada; Yasumasa Kuroda; Fumitaka Ogura; Toru Murakami; Akira Niwa; Mari Dezawa

  PloS one, 2012, Peer-reviewed

  
• Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells.

  Tomonari Awaya; Takeo Kato; Yuta Mizuno; Hsi Chang; Akira Niwa; Katsutsugu Umeda; Tatsutoshi Nakahata; Toshio Heike

  PloS one, 2012, Peer-reviewed

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• Successful cord blood transplantation using a reduced-intensity conditioning regimen for advanced childhood-onset cerebral adrenoleukodystrophy.

  Tomonari Awaya; Takeo Kato; Akira Niwa; Hidefumi Hiramatsu; Katsutsugu Umeda; Ken-Ichiro Watanabe; Minoru Shibata; Yasunari Yamanaka; Etsuko Maruya; Hiroh Saji; Tatsutoshi Nakahata; Souichi Adachi

  Pediatric transplantation, Sep. 2011, Peer-reviewed

  
• Neutrophil differentiation from human-induced pluripotent stem cells.

  Tatsuya Morishima; Ken-ichiro Watanabe; Akira Niwa; Hisanori Fujino; Hiroshi Matsubara; Souichi Adachi; Hirofumi Suemori; Tatsutoshi Nakahata; Toshio Heike

  Journal of cellular physiology, May 2011, Peer-reviewed

  
• Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.

  Itaru Kato; Akira Niwa; Toshio Heike; Hisanori Fujino; Megumu K Saito; Katsutsugu Umeda; Hidefumi Hiramatsu; Mamoru Ito; Makiko Morita; Yoko Nishinaka; Souichi Adachi; Fumihiko Ishikawa; Tatsutoshi Nakahata

  PloS one, 2011, Peer-reviewed

  
• A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.

  Akira Niwa; Toshio Heike; Katsutsugu Umeda; Koichi Oshima; Itaru Kato; Hiromi Sakai; Hirofumi Suemori; Tatsutoshi Nakahata; Megumu K Saito

  PloS one, 2011, Peer-reviewed

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• Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.

  Yuta Mizuno; Hsi Chang; Katsutsugu Umeda; Akira Niwa; Toru Iwasa; Tomonari Awaya; So-ichiro Fukada; Hiroshi Yamamoto; Shinya Yamanaka; Tatsutoshi Nakahata; Toshio Heike

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jul. 2010, Peer-reviewed

  
• Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximab.

  Itaru Kato; Katsutsugu Umeda; Tomonari Awaya; Yoshihiro Yui; Akira Niwa; Hisanori Fujino; Hiroshi Matsubara; Ken-Ichiro Watanabe; Toshio Heike; Naoto Adachi; Fumio Endo; Tomoyuki Mizukami; Hiroyuki Nunoi; Tatsutoshi Nakahata; Souichi Adachi

  Pediatric blood & cancer, Feb. 2010, Peer-reviewed

  
• Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors.

  Akira Niwa; Katsutsugu Umeda; Hsi Chang; Megumu Saito; Keisuke Okita; Kazutoshi Takahashi; Masato Nakagawa; Shinya Yamanaka; Tatsutoshi Nakahata; Toshio Heike

  Journal of cellular physiology, Nov. 2009, Peer-reviewed

  
• The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.

  Noritaka Yokoo; Shiro Baba; Shinji Kaichi; Akira Niwa; Takahiro Mima; Hiraku Doi; Shinya Yamanaka; Tatsutoshi Nakahata; Toshio Heike

  Biochemical and biophysical research communications, 25 Sep. 2009, Peer-reviewed

  
• Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

  Makoto Miyara; Yumiko Yoshioka; Akihiko Kitoh; Tomoko Shima; Kajsa Wing; Akira Niwa; Christophe Parizot; Cécile Taflin; Toshio Heike; Dominique Valeyre; Alexis Mathian; Tatsutoshi Nakahata; Tomoyuki Yamaguchi; Takashi Nomura; Masahiro Ono; Zahir Amoura; Guy Gorochov; Shimon Sakaguchi

  Immunity, 19 Jun. 2009, Peer-reviewed

  
• Frequent inactivation of A20 in B-cell lymphomas

  Motohiro Kato; Masashi Sanada; Itaru Kato; Yasuharu Sato; Junko Takita; Kengo Takeuchi; Akira Niwa; Yuyan Chen; Kumi Nakazaki; Junko Nomoto; Yoshitaka Asakura; Satsuki Muto; Azusa Tamura; Mitsuru Iio; Yoshiki Akatsuka; Yasuhide Hayashi; Hiraku Mori; Takashi Igarashi; Mineo Kurokawa; Shigeru Chiba; Shigeo Mori; Yuichi Ishikawa; Koji Okamoto; Kensei Tobinai; Hitoshi Nakagama; Tatsutoshi Nakahata; Tadashi Yoshino; Yukio Kobayashi; Seishi Ogawa

  NATURE, Jun. 2009, Peer-reviewed

  
• Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

  Atsuko Yoshioka Higashi; Tomokatsu Ikawa; Masamichi Muramatsu; Aris N Economides; Akira Niwa; Tomohiko Okuda; Andrew J Murphy; Jose Rojas; Toshio Heike; Tatsutoshi Nakahata; Hiroshi Kawamoto; Toru Kita; Motoko Yanagita

  Journal of immunology (Baltimore, Md. : 1950), 01 May 2009, Peer-reviewed

  
• Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation.

  Akira Niwa; Katsutsugu Umeda; Tomonari Awaya; Yoshihiro Yui; Hiroshi Matsubara; Hidefumi Hiramatsu; Ken-Ichiro Watanabe; Souichi Adachi; Takashi Itoh; Shinji Uemoto; Tatsutoshi Nakahata

  Pediatric transplantation, Mar. 2009, Peer-reviewed

  
• Functional delineation and differentiation dynamics \nof FoxP3-expressing subpopulation of CD4＋ T cell in humans

  Makoto Miyara; Tomoko Shima; Akihiko Kitoh; Yumiko Yosioka; Akira Niwa; Cecile Taflin; Toshio Heike; DominiqueValeyre; Alexis Mathian; Zahir Amoura; Tatsutoshi Nakahata; Tomoyuki Yamaguchi; Takashi Nomura; Kajsa Wing; Guy Gorochov; Masahiro Ono; Shimon Sakaguchi

  World Immune Regulation Meeting-II (2008.3.17-20 Davos Switzerland), 2008, Peer-reviewed

  
• Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion.

  Hisanori Fujino; Hidefumi Hiramatsu; Atsunori Tsuchiya; Akira Niwa; Haruyoshi Noma; Mitsutaka Shiota; Katsutsugu Umeda; Momoko Yoshimoto; Mamoru Ito; Toshio Heike; Tatsutoshi Nakahata

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Nov. 2007, Peer-reviewed

  
• Diabetes mellitus after stem cell transplantation in a patient with acute lymphoblastic leukemia: possible association with tacrolimus.

  Akira Niwa; Hiroshi Matsubara; Soichi Adachi; Hisanori Fujino; Yuri Higashi; Katsutsugu Umeda; Mitsutaka Shiota; Hidefumi Hiramatsu; Michihiro Kobayashi; Ken-ichiro Watanabe; Toru Yorifuji; Tatsutoshi Nakahata

  Pediatrics international : official journal of the Japan Pediatric Society, Aug. 2007, Peer-reviewed

  
• alpha 4-integrin(+) endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells

  Gen Shinoda; Katsutsugu Umeda; Toshio Heike; Masato Arai; Akira Niwa; Feng Ma; Hirofumi Suemori; Hong Yuan Luo; David H. K. Chui; Ryuzo Torii; Masabumi Shibuya; Norio Nakatsuji; Tatsutoshi Nakahata

  BLOOD, Mar. 2007, Peer-reviewed

  
• Sequential analysis of alpha- and beta-globin gene expression during erythropoietic differentiation from primate embryonic stem cells

  Katsutsugu Umeda; Toshio Heike; Mami Nakata-Hizume; Akira Niwa; Masato Arai; Gen Shinoda; Feng Ma; Hirofumi Suemori; Hong Yuan Luo; David H. K. Chui; Ryuzo Torii; Masabumi Shibuya; Norio Nakatsuji; Tatsutoshi Nakahata

  STEM CELLS, Dec. 2006, Peer-reviewed

  
• Different kinetics and function of vascular endothelial growth factor recepotor-1 and-2 during hemangioblast development from primate embryonic stem cells.

  Umeda Katsutsugu; Heike Toshio; Shinoda Gen; Niwa Akira; Arai Masato; Matsubara Hiroshi; Ma Feng; Adachi Souichi; Suemori Hirofumi; Torii Ryuzo; Shibuya Masabumi; Nakatsuji Norio; Nakahata Tatsutoshi

  BLOOD, 16 Nov. 2006, Peer-reviewed

  
• NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia.

  Masanori Yoshida; Kazuhiko Nakabayashi; Wentao Yang; Aiko Sato-Otsubo; Shin-Ichi Tsujimoto; Hiroko Ogata-Kawata; Tomoko Kawai; Keisuke Ishiwata; Mika Sakamoto; Kohji Okamura; Kaoru Yoshida; Ryota Shirai; Tomoo Osumi; Takaya Moriyama; Rina Nishii; Hiroyuki Takahashi; Chikako Kiyotani; Yoko Shioda; Keita Terashima; Sae Ishimaru; Yuki Yuza; Masatoshi Takagi; Yuki Arakawa; Akitoshi Kinoshita; Moeko Hino; Toshihiko Imamura; Daisuke Hasegawa; Yozo Nakazawa; Mayuko Okuya; Harumi Kakuda; Nao Takasugi; Akiko Inoue; Kentaro Ohki; Takako Yoshioka; Shuichi Ito; Daisuke Tomizawa; Katsuyoshi Koh; Kimikazu Matsumoto; Masashi Sanada; Nobutaka Kiyokawa; Akira Ohara; Seishi Ogawa; Atsushi Manabe; Akira Niwa; Kenichiro Hata; Jun J Yang; Motohiro Kato

  Blood advances, 14 Dec. 2021

  
• N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21.

  Hiromitsu Toshikawa; Akihiro Ikenaka; Li Li; Yoko Nishinaka-Arai; Akira Niwa; Akira Ashida; Yasuhiro Kazuki; Tatsutoshi Nakahata; Hiroshi Tamai; David W Russell; Megumu K Saito

  Scientific reports, 30 Aug. 2021

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• High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells.

  Di Cui; Alexandra Franz; Sophie A Fillon; Linda Jannetti; Timo Isambert; Katrin Fundel-Clemens; Heinrich J Huber; Coralie Viollet; Alexander Ghanem; Akira Niwa; Bernd Weigle; Stefan Pflanz

  Frontiers in cell and developmental biology, 2021

  

Misc.

• 赤芽球癆を呈したADA2欠損症の一例

  仁平 寛士; 伊佐 真彦; 芝 剛; 本田 吉孝; 下寺 佐栄子; 柴田 洋史; 田中 孝之; 井澤 和司; 八角 高裕; 西小森 隆太; 丹羽 明; 滝田 順子

  日本小児科学会雑誌, Feb. 2019

  
• 生体肝移植後に肺転移をきたし自家末梢血幹細胞移植を施行した肝芽腫の1例

  粟屋 智就; 丹羽 明; 由井 理洋; 梅田 雄嗣; 平松 英文; 渡邉 健一郎; 足立 壮一; 中畑 龍俊; 伊藤 幸司; 尾池 文隆; 阪本 靖介; 江川 裕人

  日本小児科学会雑誌, Jun. 2007

  
• 赤芽球癆を呈したADA2欠損症の一例

  仁平 寛士; 伊佐 真彦; 芝 剛; 本田 吉孝; 下寺 佐栄子; 柴田 洋史; 田中 孝之; 井澤 和司; 八角 高裕; 西小森 隆太; 丹羽 明; 滝田 順子

  日本小児科学会雑誌, Feb. 2019

  
• 小児血液・腫瘍の疾患モデル-病態解明に向けて ヒトES/iPS細胞を用いた血液・腫瘍疾患の病態解析

  丹羽 明

  日本小児血液・がん学会雑誌, Oct. 2018

  
• iPS細胞を用いた中條-西村症候群の病態解明と治療薬開発の試み

  金澤 伸雄; 尾崎 富美子; 寺嶋 聖佳; 丹羽 明; 柳町 昌克; 古川 福実; 中畑 龍俊; 斎藤 潤

  日本皮膚科学会雑誌, May 2018

  
• iPS細胞由来エリスロポエチン産生細胞を用いた腎性貧血に対する細胞療法開発

  人見 浩史; 笠原 朋子; 片桐 直子; 保科 あずさ; 前 伸一; 小高 真希; 豊原 敬文; Rahman Asadur; 中野 大介; 丹羽 明; 齋藤 潤; 中畑 龍俊; 西山 成; 長船 健二

  日本腎臓学会誌, Apr. 2018

  
• 【疾患特異的iPS細胞を用いた病態研究と創薬】 疾患特異的iPS細胞研究を支える先進技術 血液細胞の分化誘導

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  血液フロンティア, Feb. 2018

  
• ヒトiPS細胞由来エリスロポエチン産生細胞を用いた新規腎性貧血治療法の開発

  片桐直子; 人見浩史; 人見浩史; 笠原朋子; 保科あずさ; 前伸一; 豊原敬文; 小高真希; 丹羽明; 斎藤潤; 中畑龍俊; 西山成; 長船健二

  日本再生医療学会総会(Web), 2018

  
• 患者由来iPS細胞を用いたShwachman‐Diamond症候群の病態解明

  梅田雄嗣; 濱端隆行; 上月景弘; 田中孝之; 加藤格; 馬場志郎; 平松英文; 丹羽明; 齋藤潤; 上久保靖彦; 足立壯一; 長船健二; 中畑龍俊; 渡邉健一郎; 平家俊男

  日本再生医療学会総会(Web), 2018

  
• 疾患特異的iPS細胞を用いた中條‐西村症候群(NNS)の病態解析と治療法の探索

  尾崎(本田; 富美子; 寺嶋聖佳; 丹羽明; 金澤伸雄; 中畑龍俊; 斎藤潤

  日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集, 2018

  
• 【日常化するシングルセル遺伝子発現解析】 単一細胞レベルでの血管内皮分化過程の解析

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  細胞, May 2017

  
• ヒトiPS細胞由来エリスロポエチン産生細胞を用いた腎性貧血に対する細胞療法の開発

  人見浩史; 人見浩史; 笠原朋子; 片桐直子; 保科あずさ; 前伸一; 小高真希; 豊原敬文; ASADUR Rahman; 中野大介; 丹羽明; 斉藤潤; 中畑龍俊; 西山成; 長船健二

  日本薬理学会近畿部会プログラム・要旨集, 2016

  
• ヒトiPS細胞由来EPO産生細胞を用いた腎性貧血に対する細胞療法の開発

  人見 浩史; 笠原 朋子; 保科 あずさ; 前 伸一; 豊原 敬文; 小高 真希; 丹羽 明; Rahman Asadur; 齋藤 潤; 中畑 龍俊; 西山 成; 長船 健二

  日本腎臓学会誌, Apr. 2015

  
• ヒト多能牲幹細胞を用いた,完全無血清条件下での成体型ヘモグロビン産生赤芽球への効率的分化誘導法の開発

  丹羽明; 伊藤潤; 西中瑶子; 鈴木直也; 斎藤潤; 中畑龍俊

  再生医療, 01 Feb. 2015

  
• 末梢血Natural Killer細胞を用いた人工多能性幹細胞の樹立

  桐野浩輔; 尾崎富美子; 丹羽明; 中畑龍俊; 平家勇司; 斎藤潤

  再生医療, 01 Feb. 2015

  
• ヒトiPS細胞由来エリスロポエチン産生細胞を用いた腎性貧血に対する細胞療法の開発

  人見浩史; 笠原朋子; 保科あずさ; 前伸一; 豊原敬文; 小高真希; 丹羽明; RAHMAN Asadur; 斎藤潤; 中畑龍俊; 西山成; 長船健二

  再生医療, 01 Feb. 2015

  
• 【白血病幹細胞】 小児白血病の髄外病態形成機構の解明

  中畑 龍俊; 丹羽 明

  血液フロンティア, Nov. 2014

  
• 遺伝性腫瘍 基礎と臨床の架け橋 患者由来iPS細胞を用いた家族性腫瘍疾患VHL病に対する新規治療法創出の試み(Hereditary cancer: bridges between bench and bedside Development of new therapeutic strategy for VHL hereditary cancer disease by using patient-derived iPS cells)

  中村 英二郎; 室伏 善照; 今村 恵子; 丹羽 明; 杉山 愛子; 木下 和生; 新垣 隆一郎; 柴崎 昇; 山崎 俊成; 神波 大己; 斎藤 潤; 井上 治久; 小川 修

  日本癌学会総会記事, Sep. 2014

  
• ポリエチレンテレフタレート繊維で補強したコラーゲンスポンジを用いたES/iPS細胞の血球分化系の開発

  杉峰啓憲; 丹羽明; 齋藤潤; 田畑泰彦; 中畑龍俊

  再生医療, 27 Jan. 2014

  
• 血液免疫系細胞分化障害による疾患の診断と治療に関する調査研究 細網異形成症患者および重症先天性好中球減少症患者由来iPS細胞樹立およびそれを用いた病態解析

  中畑龍俊; 丹羽明; 斎藤潤; 森嶋達也; 平家俊男

  血液免疫系細胞分化障害による疾患の診断と治療に関する調査研究 平成25年度 総括・分担研究報告書, 2014

  
• 【iPS細胞への期待】 iPS細胞からの血球分化系の開発

  丹羽 明

  血液フロンティア, Jan. 2014

  
• iPS細胞由来エリスロポエチン産生細胞の腎性貧血改善効果の検討

  RAHMAN Asadur; 人見浩史; 笠原朋子; 保科あずさ; 小高真希; 丹羽明; 齋藤潤; 中畑龍俊; 西山成; 長船健二

  日本高血圧学会総会プログラム・抄録集, 24 Oct. 2013

  
• 神経細胞運動の動き解析による可視化と機能評価の可能性

  大島 志織; 中川 和博; 松居 恵理子; 矢田 博昭; 吉田 路子; 丹羽 明; 齋藤 潤; 中畑 龍俊

  The Journal of Toxicological Sciences, Jun. 2013

  
• iPS細胞およびES細胞を用いたエリスロポエチン産生細胞分化誘導法の確立

  人見 浩史; 笠原 朋子; 前 伸一; 保科 あずさ; 小高 真希; 丹羽 明; 齋藤 潤; 中畑 龍俊; 西山 成; 長船 健二

  日本内分泌学会雑誌, Apr. 2013

  
• iPS細胞およびES細胞を用いたエリスロポエチン産生細胞分化誘導法の確立

  人見 浩史; 笠原 朋子; 前 伸一; 保科 あずさ; 小高 真希; 丹羽 明; 齋藤 潤; 中畑 龍俊; 西山 成; 長船 健二

  日本腎臓学会誌, Apr. 2013

  
• iPS細胞を用いた先天性好中球減少症 （HAX1 遺伝子異常）の疾患モデル

  森嶋達也; 渡邉健一郎; 丹羽明; 平位秀世; 田中孝之; 才田聡; 加藤格; 梅田雄嗣; 平松英文; 松原康策; 足立壯一; 小林正夫; 中畑龍俊; 平家俊男

  第8回 Kyoto Hematology Forum (京都), Mar. 2013

  
• ヒトiPS細胞およびES細胞を用いたエリスロポエチン産生細胞分化誘導法の確立

  人見浩史; 笠原朋子; 前伸一; 保科あずさ; 小高真希; 丹羽明; 齋藤潤; 中畑龍俊; 西山成; 長船健二

  日本腎臓リハビリテーション学会学術集会プログラム・抄録集, 2013

  
• 特発性造血障害に関する調査研究 Fanconi貧血患者iPS細胞由来血液・血管内皮細胞はALDH2酵素活性により影響を受ける

  中畑龍俊; 前川直也; 丹羽明; 斎藤潤; 矢部みはる; 矢部普正

  特発性造血障害に関する調査研究 平成24年度 総括・分担研究報告書, 2013

  
• 原発性免疫不全症に対する造血幹細胞移植法の確立 iPS細胞を用いた血球分化系の構築およびX連鎖性血小板減少症に対する造血幹細胞移植成績の後方視的検討

  中畑龍俊; 大嶋宏一; 丹羽明; 斎藤潤

  原発性免疫不全症に対する造血幹細胞移植法の確立 平成24年度 総括・分担研究報告書, 2013

  
• 血液免疫系細胞分化障害による疾患の診断と治療に関する調査研究 細網異形成症患者および重症先天性好中球減少症患者由来iPS細胞樹立およびそれを用いた病態解析

  中畑龍俊; 大嶋宏一; 丹羽明; 斎藤潤; 森嶋達也; 平家俊男

  血液免疫系細胞分化障害による疾患の診断と治療に関する調査研究 平成24年度 総括・分担研究報告書, 2013

  
• NOGマウスを用いたTAMの病態解析

  才田 聡; 渡邉 健一郎; 佐藤 亜以子; 照井 君典; 吉田 健一; 奥野 友介; 土岐 力; 王 汝南; 白石 友一; 宮野 悟; 加藤 格; 森嶋 達也; 梅田 雄嗣; 平松 英文; 藤野 寿典; 足立 壮一; 丹羽 明; 中畑 龍俊; 伊藤 悦朗; 小川 誠司; 平家 俊男

  日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, Nov. 2012

  
• 顕微鏡的多発血管炎(MPA) 特異的iPS細胞の樹立と病態解析研究

  天久 朝廷; 荒岡 利和; 田浦 大輔; 丹羽 明; 菅又 龍一; 曽根 正勝; 斎藤 潤; 浅香 勲; 武曾 惠理; 深津 敦司; 中畑 龍俊; 中尾 一和; 鈴木 和男; 長船 健二

  日本腎臓学会誌, Apr. 2012

  
• 【造血幹細胞移植の最新動向】 造血幹細胞移植のトピックス 幹細胞の体外増幅法の現状と将来

  丹羽 明; 中畑 龍俊

  医学のあゆみ, Feb. 2012

  
• 特発性造血障害に関する調査研究 造血障害を来す先天性疾患患者からの疾患特異的iPS細胞の樹立

  中畑龍俊; 前川直也; 大嶋宏一; 丹羽明; 斎藤潤; 矢部みはる; 矢部晋正

  特発性造血障害に関する調査研究 平成23年度 総括・分担研究報告書, 2012

  
• 疾患特異的iPS細胞を用いた今後の医療

  中畑 龍俊; 斎藤 潤; 丹羽 明; 田中 孝之; 平家 俊男

  日本医学会総会会誌, Oct. 2011

  
• 疾患特異的iPS細胞を用いた今後の医療

  中畑 龍俊; 斎藤 潤; 丹羽 明; 田中 孝之; 平家 俊男

  日本医学会総会会誌, Oct. 2011

  
• B細胞性悪性リンパ腫におけるA20の遺伝子変異による不活性化

  加藤元博; 真田 昌; 加藤 格; 佐藤康晴; 滝田順子; 竹内賢吾; 丹羽明; 陳 玉彦; 中崎久美; 野本順子; 朝倉義崇; 赤塚美紀; 林 泰秀; 森 啓; 五十嵐隆; 黒川峰夫; 千葉,滋; 森 茂郎; 石川雄一; 岡本康司; 飛内賢正; 中 釜斉; 中畑龍俊; 吉野 正; 小林幸夫; 小川誠司

  臨床血液, Jun. 2011, Peer-reviewed

  
• [Frequent inactivation of A20 through gene mutation in B-cell lymphomas].

  Motohiro Kato; Masashi Sanada; Itaru Kato; Yasuharu Sato; Junko Takita; Kengo Takeuchi; Akira Niwa; Yuyan Chen; Kumi Nakazaki; Junko Nomoto; Yositaka Asakura; Miki Akatsuka; Yasuhide Hayashi; Hiraku Mori; Takashi Igarashi; Mineo Kurokawa; Shigeru Chiba; Shigeo Mori; Yuichi Ishikawa; Koji Okamoto; Kensei Tobinai; Hitoshi Nakagama; Tatsutoshi Nakahata; Tadashi Yoshino; Yukio Kobayashi; Seishi Ogawa

  [Rinsho ketsueki] The Japanese journal of clinical hematology, Jun. 2011, Peer-reviewed

  
• ヒト多能性幹細胞由来造血支持細胞を用いた,二次元無血清条件における造血分化の定量評価

  丹羽明; 斎藤潤; 大嶋宏一; 加藤格; 田中孝之; 末盛博文; 平家俊男; 中畑龍俊

  再生医療, 01 Feb. 2011

  
• ヒトES/iPS細胞を用いた,二次元無血清条件における造血幹・前駆細胞および成熟血球誘導の試み

  丹羽明; 斎藤潤; 大嶋宏一; 加藤格; 田中孝之; 杉峰啓憲; 前川直也; 柳町昌克; 酒井宏水; 末盛博文; 中畑龍俊

  日本造血細胞移植学会総会プログラム・抄録集, 2011

  
• [Derivation of engraftable myogenic precursors from murine ES/iPS cells and generation of disease-specific iPS cells from patients with Duchenne muscular dystrophy (DMD) and other diseases].

  Tatsutoshi Nakahata; Tomonari Awaya; Hsi Chang; Yuta Mizuno; Akira Niwa; So-ichiro Fukada; Shin'ichi Takeda; Shinya Yamanaka; Toshio Heike

  Rinsho shinkeigaku = Clinical neurology, Nov. 2010, Peer-reviewed

  
• 組織幹細胞による臓器再生 マウス胚性幹細胞および誘導多能性幹細胞からの骨格筋幹/前駆細胞の誘導と移植効果

  粟屋 智就; 張 璽; 水野 雄太; 丹羽 明; 加藤 竹雄; 深田 宗一朗; 山元 弘; 山中 伸弥; 中畑 龍俊; 平家 俊男

  Inflammation and Regeneration, Jul. 2010

  
• ヒトES/iPS細胞からのin vitro二次元無血清造血誘導における、分化過程の経時的解析

  丹羽 明; 斉藤 潤; 加藤 格; 大嶋 宏一; 末盛 博文; 平家 俊男; 中畑 龍俊

  Inflammation and Regeneration, Jul. 2010

  
• Unique multipotent cells in adult human mesenchymal cell populations

  Yasumasa Kuroda; Masaaki Kitada; Shohei Wakao; Kouki Nishikawa; Yukihiro Tanimura; Hideki Makinoshima; Makoto Goda; Hideo Akashi; Ayumu Inutsuka; Akira Niwa; Taeko Shigemoto; Yoko Nabeshima; Tatsutoshi Nakahata; Yo-ichi Nabeshima; Yoshinori Fujiyoshi; Mari Dezawa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2010, Peer-reviewed

  
• ヒトES/iPS 細胞からの試験管内造血系を用いた分化過程の解析

  丹羽明; 斎藤潤; 加藤格; 大嶋宏一; 百瀬大; 高橋和利; 末盛博文; 中辻憲夫; 山中伸弥; 平家俊男; 中畑龍俊

  第9 回日本再生医療医学会総会 （2010.3.19 広島）, 2010, Peer-reviewed

  
• iPS細胞由来赤芽球系分化の経時的解析と成熟血球の機能評価

  丹羽明; 丹羽明; 深津智樹; 梅田雄嗣; 張璽; 森嶋達也; 才田聡; 斎藤潤; 沖田圭介; 酒井宏水; 山中伸弥; 平家俊男; 中畑龍俊

  臨床血液, 30 Sep. 2009

  
• 白血病細胞と髄外微小環境の解析

  加藤 格; 丹羽 明; 平家 俊男; 藤野 寿典; 才田 聡; 足立 壮一; 中畑 龍俊

  臨床血液, Sep. 2009

  
• B細胞性悪性リンパ腫に対する網羅的ゲノム解析によるがん抑制遺伝子A20の同定(Genome-wide analysis identifies frequent inactivation of A20 in B-cell lymphomas)

  加藤 元博; 真田 昌; 加藤 格; 佐藤 康晴; 竹内 賢吾; 丹羽 明; 野本 順子; 中釜 斉; 石川 雄一; 中畑 龍俊; 吉野 正; 小林 幸夫; 小川 誠司

  日本癌学会総会記事, Aug. 2009

  
• GENOME-WIDE ANALYSIS IDENTIFYS FREQUENT INACTIVATION OF A20 IN B-CELL TYPE MALIGNANT LYMPHOMAS

  M. Kato; M. Sanada; I. Kato; Y. Sato; J. Takita; K. Takeuchi; A. Niwa; Y. Chen; K. Nakazaki; J. Nomoto; Y. Asakura; Y. Akatsuka; Y. Hayashi; H. Mori; T. Igarashi; M. Kurokawa; S. Chiba; S. Mori; Y. Ishikawa; K. Okamoto; K. Tobinai; H. Nakagama; T. Nakahata; T. Yoshino; Y. Kobayashi; S. Ogawa

  HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Jun. 2009

  
• 網羅的ゲノム解析によるB細胞性リンパ腫における標的遺伝子A20の同定

  加藤 元博; 真田 昌; 加藤 格; 佐藤 康晴; 滝田 順子; 竹内 賢吾; 丹羽 明; 陳 玉彦; 中崎 久美; 野本 順子; 朝倉 義崇; 赤塚 美樹; 林 泰秀; 五十嵐 隆; 黒川 峰夫; 千葉 滋; 森 茂郎; 石川 雄一; 岡本 康司; 飛内 賢正; 中釜 斉; 中畑 龍俊; 吉野 正; 小林 幸夫; 小川 誠司

  日本リンパ網内系学会会誌, Jun. 2009

  
• マウスiPS細胞からの移植可能な骨格筋前駆細胞の作成

  水野雄太; 張璽; 丹羽明; 梅田雄嗣; 粟屋智就; 深田宗一朗; 山元弘; 山中伸弥; 平家俊男; 中畑龍俊

  再生医療, 05 Feb. 2009

  
• iPS細胞からのin vitro選択的赤血球分化誘導における経時的解析と機能評価

  深津智樹; 丹羽明; 梅田雄嗣; 張璽; 森嶋達也; 沖田圭介; 酒井宏水; 山中伸弥; 平家俊男; 中畑龍俊

  再生医療, 05 Feb. 2009

  
• マウスiPS細胞からの試験管内分化誘導における,一次・二次造血の経時的分化

  丹羽明; 梅田雄嗣; 張璽; 深津智樹; 才田聡; 加藤格; 森嶋達也; 田中孝之; 沖田圭介; 高橋和則; 中川誠人; 山中伸弥; 平家俊男; 中畑龍俊

  再生医療, 05 Feb. 2009

  
• B細胞性リンパ腫における標的遺伝子A20の欠失

  加藤元博; 真田昌; 加藤格; 佐藤康晴; 滝田順子; 竹内賢吾; 丹羽明; 野本順子; 林泰秀; 五十嵐隆; 黒川峰夫; 千葉滋; 石川雄一; 岡本康司; 飛内賢正; 中釜斉; 中畑龍俊; 吉野正; 小林幸夫; 小川誠司

  日本人類遺伝学会大会プログラム・抄録集, 2009

  
• 造血幹細胞 iPS細胞からの造血分化

  丹羽 明; 中畑 龍俊

  Annual Review血液, Jan. 2009

  
• マウスiPS細胞からの試験管内造血誘導における、分化過程の経時的解析とヘマンジオブラストの同定

  丹羽 明; 梅田 雄嗣; 張 璽; 深津 智樹; 才田 聡; 粟屋 智就; 加藤 格; 森嶋 達也; 田中 孝之; 沖田 圭介; 高橋 和利; 中川 誠人; 山中 伸弥; 平家 俊男; 中畑 龍俊

  臨床血液, Sep. 2008

  
• iPS細胞を用いた一次造血・二次造血の試験管内分化誘導

  丹羽明; 梅田雄嗣; 張璽; 森嶋達也; 粟屋智就; 加藤格; 沖田圭介; 高橋和利; 山中伸弥; 平家俊男; 中畑龍俊

  Inflammation and Regeneration, 01 Jul. 2008

  
• ボリコナゾールを含めた抗真菌剤多剤併用療法が著効した骨髄移植後の重症アスペルギルス感染症の2症例

  岩田 あや; 梅田 雄嗣; 丹羽 明; 由井 理洋; 平松 英文; 渡邉 健一郎; 足立 壮一; 中畑 龍俊

  日本小児血液学会雑誌, Feb. 2008

  
• 霊長類ES細胞からのヘマンギオブラストの分化誘導におけるVEGF関連因子の作用の検討

  梅田 雄嗣; 平家 俊男; 丹羽 明; 松原 央; 横尾 憲孝; 美馬 隆宏; 足立 壮一; 末盛 博文; 鳥居 隆三; 渋谷 正史; 中辻 憲夫; 中畑 龍俊

  臨床血液, Sep. 2007

  
• 小児造血幹細胞移植におけるシクロスポリン3時間点滴静注法とC3モニタリングの有用性についての検討

  松原 央; 小林 道弘; 由井 理洋; 加藤 格; 丹羽 明; 新井 真人; 宮崎 真紀; 水嶋 康浩; 梅田 雄嗣; 平松 英文; 渡邉 健一郎; 足立 壯一; 中畑 龍俊

  臨床血液, Aug. 2007

  
• [Continuous infusion of cyclosporine A and C3 monitoring in pediatric stem cell transplantation].

  Hiroshi Matsubara; Michihiro Kobayashi; Yoshihiro Yui; Itaru Kato; Akira Niwa; Masato Arai; Maki Miyazaki; Yasuhiro Mizushima; Katsutsugu Umeda; Hidefumi Hiramatsu; Ken-ichiro Watanabe; Souichi Adachi; Tatsutoshi Nakahata

  [Rinsho ketsueki] The Japanese journal of clinical hematology, Aug. 2007, Peer-reviewed

  
• 骨髄非破壊的前処置を用いて骨髄移植を行った慢性肉芽腫症の2例

  三國 貴康; 梅田 雄嗣; 岩田 あや; 粟屋 智就; 高原 賢守; 濱本 奈央; 由井 理洋; 丹羽 明; 岡藤 郁夫; 平松 英文; 渡邉 健一郎; 足立 壮一; 平家 俊男; 中畑 龍俊; 水上 智之; 布井 博幸; 足立 尚登

  日本小児科学会雑誌, Jun. 2007

  
• ヒト臍帯血CD34陽性細胞は細胞融合を介しNOD/SCID/γ_c^nullマウスの肝臓内で肝細胞へと発育する

  藤野寿典; 平松英文; 丹羽明; 平家俊男; 中畑龍俊

  再生医療, 19 Feb. 2007

  
• 霊長類ES細胞から選択的分化誘導した赤血球の性状解析

  梅田 雄嗣; 平家 俊男; 丹羽 明; 新井 真人; 馬 峰; 末盛 博文; 鳥居 隆三; 渋谷 正史; 中辻 憲夫; 中畑 龍俊

  臨床血液, Sep. 2006

  
• ヒト臍帯血CD34陽性細胞は肝傷害無しにNOD/SCID/γcnullマウスの肝臓内で肝細胞へと発育する

  藤野 寿典; 平松 英文; 丹羽 明; 平家 俊男; 中畑 龍俊

  臨床血液, Sep. 2006

  
• DLI後の汎血球減少症に対してRituximabが著効した慢性肉芽腫症の一例

  粟屋 智就; 由井 理洋; 丹羽 明; 梅田 雄嗣; 平松 英文; 渡邉 健一郎; 足立 壮一; 中畑 龍俊; 足立 尚登; 水上 智之; 布井 博幸

  臨床血液, Sep. 2006

  
• 皮膚腫瘤で発見された小児ALLの1例

  濱本 奈央; 由井 理洋; 丹羽 明; 梅田 雄嗣; 平松 英文; 小林 道弘; 足立 壮一; 中畑 龍俊

  日本小児科学会雑誌, Jul. 2006

  
• 骨髄非破壊的前処置を用いて骨髄移植を行った慢性肉芽腫症の2例

  三國 貴康; 梅田 雄嗣; 岩田 あや; 粟屋 智就; 高原 賢守; 濱本 奈央; 由井 理洋; 丹羽 明; 岡藤 郁夫; 平松 英文; 渡邉 健一郎; 足立 壮一; 平家 俊男; 中畑 龍俊; 水上 智之; 布井 博幸; 足立 尚登

  日本小児科学会京都地方会会報, May 2006

  
• Imatinib併用化学療法後,2度目の臍帯血移植を施行したPh1陽性急性リンパ性白血病

  丹羽 明; 平松 英文; 清水 滋太; 高原 賢守; 由井 理洋; 梅田 雄嗣; 小林 道弘; 渡邊 健一郎; 足立 壮一; 中畑 龍俊

  日本小児科学会雑誌, Feb. 2006

  
• 24OP6-14 生体肝移植後に肺転移をきたし自家末梢血幹細胞移植を施行した肝芽腫の一例(ポスター 肝芽腫,第22回日本小児がん学会 第48回日本小児血液学会 第4回日本小児がん看護研究会 同時期開催)

  梅田 雄嗣; 粟屋 智就; 丹羽 明; 由井 理洋; 平松 英文; 渡邉 健一郎; 足立 壮一; 中畑 龍俊; 伊藤 幸司; 尾池 文隆; 阪本 靖介; 江川 裕人; 上本 伸二

  小児がん : 小児悪性腫瘍研究会記録, 2006

  
• 26HO8-2 造血幹細胞移植後の重症アスペルギルス感染症に対してボリコナゾールを含む抗真菌剤併用が著効した2例(口演「感染症」,第22回日本小児がん学会 第48回日本小児血液学会 第4回日本小児がん看護研究会 同時期開催)

  岩田 あや; 梅田 雄嗣; 安部 大輔; 高原 賢守; 濱本 奈央; 由井 理洋; 丹羽 明; 平松 英文; 渡邊 健一郎; 足立 壮一; 中畑 龍俊

  小児がん : 小児悪性腫瘍研究会記録, 2006

  
• 生体肝移植後に肺転移をきたし自家末梢血幹細胞移植を施行した肝芽腫の一例

  梅田雄嗣; 粟屋智就; 丹羽明; 由井理洋; 平松英文; 渡邉健一郎; 足立壮一; 中畑龍俊; 伊藤幸司; 尾池文隆; 阪本靖介; 江川裕人; 上本伸二

  日本小児血液学会、2006年20巻421頁, 2006, Peer-reviewed

  
• 造血幹細胞移植後の重症アスペルギルス感染症に対してボリコナゾールを含む抗真菌剤併用が著効した2例

  岩田あや; 梅田雄嗣; 安部大輔; 高原賢守; 濱本奈央; 由井理洋; 丹羽明; 平松英文; 渡邊健一郎; 足立壮一; 中畑龍俊

  日本小児血液学会、2006年20巻 364頁, 2006, Peer-reviewed

  
• 皮膚腫瘤で発見された小児ALLの一例

  濱本 奈央; 由井 理洋; 丹羽 明; 梅田 雄嗣; 平松 英文; 小林 道弘; 足立 壮一; 中畑 龍俊

  日本小児科学会京都地方会会報, Sep. 2005

  
• OO3-3 肝芽腫肝移植後のCMV再活性化リスクとモニタリング(口演 肝芽腫,第21回日本小児がん学会 第47回日本小児血液学会 同時期開催)

  丹羽 明; 小林 道弘; 由井 理洋; 新井 真人; 梅田 雄嗣; 平松 英文; 足立 壮一; 中畑 龍俊; 上田 幹子; 江川 裕人; 田中 紘一

  小児がん : 小児悪性腫瘍研究会記録, 2005

  
• 肝芽腫肝移植後のCMV再活性化リスクとモニタリング

  丹羽明; 小林道弘; 由井理洋; 新井真人; 梅田雄嗣; 平松英文; 足立壮一; 中畑龍俊; 上田幹子; 江川裕人; 田中紘一

  日本小児血液学会、2005年19巻317頁, 2005, Peer-reviewed

  
• 胃食道逆流を認めた難治性喘息の3小児例

  丹羽 明; 楠 隆; 泰永 美千穂; 田邊 卓也; 西小森 隆太; 平家 俊男; 中畑 龍俊

  アレルギーの臨床, May 2003

  
• 胃食道逆流を認めた難治性喘息の2小児例

  丹羽 明; 楠 隆; 泰永 美千穂; 田邊 卓也; 西小森 隆太; 平家 俊男; 中畑 龍俊

  アレルギー, Oct. 2002

  
• 非血縁者間同種骨髄移植後に糖尿病を発病した急性リンパ性白血病の1例

  丹羽 明; 松原 央; 前田 彰久; 藤野 寿典; 東 ゆり; 塩田 光隆; 渡邉 健一郎; 足立 壮一; 依藤 享; 中畑 龍俊

  医学と薬学, Aug. 2002

  

Presentations

• NK Cells from Human Pluripotent Stem Cells for Immunotherapy

  Maysubara Hiroyuki; Niwa Akira; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 29 Nov. 2018

  
• iPSC-Based Phenomic Screen Revealed an Impact of Uncontrolled NFkB Activity at the Initiating Stages of AML1-ETO Related Leukemia

  Niwa Akira; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 29 Nov. 2018

  
• Identification of Candidate Progenitor Populations Which Causes Transient Abnormal Myelopoiesis

  Nishinaka-Arai Yoko; Niwa Akira; Matsuo Shiori; Kazuki Yasuhiro; Yakura Yuwna; Oshimura Mitsuo; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 07 Dec. 2017

  
• Exogenously Added Cofilin Increases Ex Vivo Production of Functional Platelets By Stimulating Proplatelet Formation

  Haruyama Munetada; Niwa Akira; Saito Megumu K; Nakahata Tatsutoshi

  BLOOD, 07 Dec. 2017

  
• PSC-Derived Hematopoietic System to Elucidate the Cooperation Between Gene Alterations and Cell Lineages in Leukemogenesis

  Niwa Akira; Saito Megumu K; Nakahata Tatsutoshi

  BLOOD, 02 Dec. 2016

  
• Hepatoma-Derived Growth Factor Is a Novel Factor to Promote the Proliferation of Hematopoietic Stem Cells

  Haruyama Munetada; Yamaichi Kozo; Niwa Akira; Saito Megumu K; Nakahata Tatsutoshi

  BLOOD, 02 Dec. 2016

  
• Induction of Natural Killer Cells from Human Pluripotent Stem Cells Under Chemically Defined Condition

  Matsubara Hiroyuki; Niwa Akira; Nakahata Tatsutoshi; Saito Megumu K

  BLOOD, 02 Dec. 2016

  
• VEGFA- a New Therapeutic Target in CNS Leukemia

  Kato Itaru; Nishinaka-Arai Yoko; Nakamura Masahiro; Akarca Ayse U; Niwa Akira; Ozawa Hiroki; Yoshida Kenichi; Mori Makiko; Wang Dapeng; Ueno Hiroo; Shiozawa Yusuke; Shiraishi Yuichi; Miyano Satoru; Gupta Rajeev; Umeda Katsutsugu; Watanabe Kenichiro; Koh Katsuyoshi; Adachi Souichi; Heike Toshio; Saito Megumu K; Sanada Masashi; Ogawa Seishi; Marafioti Teresa; Watanabe Akira; Nakahata Tatsutoshi; Enver Tariq

  BLOOD, 02 Dec. 2016

  
• Recapitulation of Transient Abnormal Myelopoiesis Using Patient Derived iPSCs

  Yoko Nishinaka-Arai; Akira Niwa; Mitsujiro Osawa; Tatsutoshi Nakahata; Megumu K. Saito

  BLOOD, Dec. 2015, AMER SOC HEMATOLOGY

  
• MONOCYTES DIFFERENTIATED FROM IPS CELLS DERIVED FROM RHEUMATOID ARTHRITIS PATIENTS EXPRESS MORE M-SCF-RECEPTOR TOGETHER WITH RANK THAN THOSE FROM HEALTHY DONORS RESULTING IN THE ACCELERATED OSTEOCLASTGENESIS

  M. N. Ito; M. Murakami; M. Saito; A. Niwa; M. Osawa; T. Nakahata; N. Nishimoto

  ANNALS OF THE RHEUMATIC DISEASES, Jun. 2015, BMJ PUBLISHING GROUP

  
• PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Ph+ Leukemia with T315I Mutation in Bcr-Abl; In Vivo Analysis Using Xenograft Mice Model

  Saida Satoshi; Kato Itaru; Inukai Takeshi; Nemoto Atsushi; Sugita Kanji; Maeda Yasuhiro; Niwa Akira; Watanabe Ken-ichiro; Nakahata Tatsutoshi; Heike Toshio

  BLOOD, 18 Nov. 2011

  
• Reduced Production of Mature Neutrophils From Induced Pluripotent Stem Cells Derived From a Severe Congenital Neutropenia Patient with HAX1 Gene Deficiency

  Morishima Tatsuya; Watanabe Ken-ichiro; Niwa Akira; Tanaka Takayuki; Umeda Katsutsugu; Hiramatsu Hidefumi; Matsubara Kousaku; Adachi Souichi; Nakahata Tatsutoshi; Heike Toshio

  BLOOD, 18 Nov. 2011

  
• Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/gamma c (Null) Mouse

  Itaru Kato; Akira Niwa; Megumu Saito; Hisanori Fujino; Satoshi Saida; Hidefumi Hiramatsu; Koichi Oshima; Mamoru Ito; Souichi Adachi; Toshio Heike; Tatsutoshi Nakahata

  BLOOD, Nov. 2010, AMER SOC HEMATOLOGY

  

External funds: Kakenhi

• Investigation of new erythropoietin resistance factors and the mechanisms: with special attentions to associations between erythropoiesis and lipid metabolism

  Grant-in-Aid for Scientific Research (C)

  Basic Section 52010:General internal medicine-related

  University of Fukui

  Hideki Kimura

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  腎性腎血;エリスロポエチン;血液透析患者;アシルカルニチン;脂肪酸β酸化;血清脂質;網赤血球数;腎性貧血;エリスロポエチン抵抗性;亜鉛;CPT-1α;アディポネクチン;赤芽球;脂質因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07844/
• Study on the clonal evolution of leukemia induced with internal mutators

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akira Niwa

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  白血病;iPS細胞;疾患モデル;白血病モデル;クローン進化;癌;遺伝子;シグナル伝達;発現制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10026/
• Identification of causative genes for hemangioblastoma to elucidate the mechanisms of neovascularization and to develop novel therapeutic strategies

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  Akitake Mukasa

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  血管芽腫;VHL病;腫瘍血管新生;癌抑制遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670636/
• Induction and expansion of PSC-derived HSCs by manipulating culture microenvironment

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Tatsutoshi Nakahata

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  造血幹細胞;ES/iPS細胞;移植・再生医療;臨床応用;細胞内代謝;ストロマ細胞;ニッチ;ES／iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670498/
• Phenomic Screen to Explore Novel Pathogenesis of Leukemia Using PSC-Derived Hematopoietic Cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Akira NIWA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  白血病;造血発生;ＥＳ／ｉＰＳ細胞;順遺伝学;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860856/
• Hematopoietic stem cell potential is propagated by human pluripotent stem cell-derived endothelial stroma

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Tatsutoshi NAKAHATA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  ES細胞;iPS細胞;造血幹細胞;ストロマ細胞;ニッチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659496/
• Induction of hematopoietic stem/progenitor cells and functional blood cells from human ES/iPS cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Akira NIWA

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  造血発生;中胚葉分化;無血清培養;再生医学;ES/iPS細胞;ヒトES/iPS細胞;造血細胞分化;ヒトES細胞;ヒトiPS細胞;造血分化;造血幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790979/
• Recapitulation of phenotypes and discovery of a novel treatment with disease-specific human ES/ iPS cells from various hereditary diseases

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Tatsutoshi NAKAHATA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  遺伝性疾患;iPS細胞;遺伝子改変;疾患解析;NOGマウス;疾患特異的;創薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22249042/

External funds: others

• 小児白血病の病態の背景にある生殖細胞系列の分子遺伝学的基盤の解明

  革新的がん医療実用 化研究事業(AMED)

  From 01 Apr. 2019, To 31 Mar. 2021

  分担

Administration

School management (title, position)

• From 01 Apr. 2018, To 31 Mar. 2020

  環境管理専門委員会有機廃液情報管理小委員会

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2026

  共通機器管理運営委員会3号委員
• From 01 Apr. 2016, To 31 Mar. 2018

  動物実験委員会
• From 01 Aug. 2019

  放射線管理責任者
• From 01 Aug. 2019

  放射線障害防止委員会（放射線管理責任者）
• From 01 Sep. 2019, To 31 Aug. 2021

  特定放射性同位元素防護委員会（防護従事者）