Basic Information

Faculty

• 医学部

Academic Degree

• 修士（医科学）(北海道大学)
• 博士（医学）(北海道大学)

Research History

• From Apr. 2019, To Dec. 2020

  Foundation for Biomedical Research and Innovation, Institute for Biomedical Research and Innovation, Senior Investigator
• From Jun. 2017, To Dec. 2020

  Kyoto University, Graduate School of Medicine, Assistant Professor
• From Jun. 2017, To Mar. 2019

  Foundation for Biomedical Research and Innovation, Institute of Biomedical Research and Innovation, Researcher
• From May 2012, To May 2017

  National Institutes for Health, National Institute of Allergy and Infectious Diseases, Visiting fellow
• From Jan. 2014, To Dec. 2015

  National Institutes of Health, National Institute of Allergy and Infectious Diseases, Postdoctoral Fellowships of Japan Society for the Promotion of Science (NIH)
• From Apr. 2009, To Mar. 2012

  Hokkaido University, Graduate School of Medicine, JSPS Research Fellowship for Young Scientists

ID,URL

• ORCID ID

  0000-0003-3407-0229

• J-Global ID

  202001001580073436

• Researcher number

  50815032

researchmap URL

• https://researchmap.jp/masakitajima

Research

Research Interests

• Oncology
• Metabolism
• Immunology

Papers

• Purine salvage pathway protects CD8+ T cells from metabolic stress

  Masaki Tajima; He Hao; Baihao Zhang; Yuta Matsuoka; Kazuhiro Sonomura; Koshi Imami; Yosuke Isobe; Rae Maeda; Yu-Hsien Lin; Akihiro Shimba; Ryoma Kato; Pedro Henrique Costa Cruz; Sayaka Washizu; Yosuke Ikejiri; Akiyo Morinibu; Clive Steven Barker; Jun Seita; Yibo Wu; Satomi Ito; Seiko Narushima; Rei Nakano; Mikako Maruya; Wakana Kobayashi; Sai Shanmukha Priya Narayanan; Jumana Shaheen; Hiroyuki Neyama; Ken-ichi Yamada; Makoto Arita; Yuki Sugiura; Sidonia Fagarasan

  Nature Immunology, 13 Apr. 2026, Peer-reviewed, Lead author, Corresponding author

  
• Monitoring ferroptosis in vivo: Iron-driven volatile oxidized lipids as breath biomarkers.

  Yuta Matsuoka; Yoshinori Katsumata; Po-Sung Chu; Rei Morikawa; Nobuhiro Nakamoto; Kohta Iguchi; Ken Takahashi; Tadayuki Kou; Ryo Ito; Kojiro Taura; Shujiro Yazumi; Hiroaki Terajima; Gen Honjo; Genki Ichihara; Yuki Muramoto; Kazuki Sato; Rae Maeda; Kazuhiro Hata; Naoya Toriu; Motoko Yanagita; Masaki Tajima; Sidonia Fagarasan; Ken-Ichi Yamada; Yuki Sugiura

  Redox biology, Oct. 2025, Peer-reviewed

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• Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells.

  Akihiro Shimba; Guangwei Cui; Shinya Abe; Keiji Hirota; Eiji Miyauchi; Daichi Takami; Shizue Tani-Ichi; Ryoma Kato; Masaki Tajima; Toru Kanahashi; Masaki Miyazaki; Hans-Reimer Rodewald; Hiroyuki Yoshitomi; Hideki Ueno; Hiroshi Ohno; Koichi Ikuta

  Cell reports, 26 Aug. 2025, Peer-reviewed

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• Prediction of postoperative delirium by blood metabolome analysis.

  Naohiro Arai; Yuki Sugiura; Shinichiro Nakajima; Masataka Wada; Sotaro Moriyama; Yu Mimura; Kanta Niinomi; Kousuke Takayama; Rae Maeda; Seri Kitada; Sidonia Fagarasan; Masaki Tajima; Shuken Boku; Minoru Takebayashi; Jungo Kato; Minoru Kitago; Yuko Kitagawa; Tatsuo Takahashi; Hideyuki Shimizu; Hiroyuki Uchida; Makoto Suematsu; Masaru Mimura; Yoshihiro Noda

  Journal of psychiatric research, Apr. 2025, Peer-reviewed

  
• Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells

  Siwakorn Punyawatthananukool; Ryuma Matsuura; Thamrong Wongchang; Nao Katsurada; Tatsuaki Tsuruyama; Masaki Tajima; Yutaka Enomoto; Toshio Kitamura; Masahiro Kawashima; Masakazu Toi; Koji Yamanoi; Junzo Hamanishi; Shigeo Hisamori; Kazutaka Obama; Varodom Charoensawan; Dean Thumkeo; Shuh Narumiya

  Nature Communications, 01 Nov. 2024, Peer-reviewed

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• PD-1 negatively regulates helper T cell differentiation into Th2

  Masaki Tajima; Naoko Ikuta; Yuka Nakajima; Kensuke Suzuki; Yosuke Tokumaru; Peng Li; Hiroshi Kiyonari; Tasuku Honjo; Akio Ohta

  eLife, 08 Oct. 2024, Peer-reviewed, Lead author

  
• Blocking S100A9-signaling is detrimental to the initiation of anti-tumor immunity.

  Melike Fusun Demir; Yu-Hsien Lin; Pedro Henrique Costa Cruz; Masaki Tajima; Tasuku Honjo; Elisabeth Müller

  Frontiers in immunology, 2024, Peer-reviewed, Corresponding author

  
• Spermidine – an old molecule with a new age-defying immune function

  Kenji Chamoto; Baihao Zhang; Masaki Tajima; Tasuku Honjo; Sidonia Fagarasan

  Trends in Cell Biology, Sep. 2023

  
• Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

  Kenji Chamoto; Tomonori Yaguchi; Masaki Tajima; Tasuku Honjo

  Nature Reviews Immunology, 25 Apr. 2023, Peer-reviewed, Lead author

  
• Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases.

  Kensuke Suzuki; Masaki Tajima; Yosuke Tokumaru; Yuya Oshiro; Satoshi Nagata; Haruhiko Kamada; Miho Kihara; Kohei Nakano; Tasuku Honjo; Akio Ohta

  Science immunology, 13 Jan. 2023, Peer-reviewed, Lead author

  
• Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

  Muna Al-Habsi; Kenji Chamoto; Ken Matsumoto; Norimichi Nomura; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Aprilia Maharani; Yuka Nakajima; Yibo Wu; Yayoi Nomura; Rosemary Menzies; Masaki Tajima; Koji Kitaoka; Yasuharu Haku; Sara Delghandi; Keiko Yurimoto; Fumihiko Matsuda; So Iwata; Toshihiko Ogura; Sidonia Fagarasan; Tasuku Honjo

  Science, 28 Oct. 2022, Peer-reviewed

  
• Evaluation of Glutaminolysis in T Cells.

  Masaki Tajima; Warren Strober

  Current protocols, Sep. 2022, Peer-reviewed, Lead author

  
• STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T-cell sensitivity to PD-1-dependent immunoregulation.

  Guanning Wang; Masaki Tajima; Tasuku Honjo; Akio Ohta

  International immunology, 29 Oct. 2021, Peer-reviewed

  
• Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events.

  Matin Dokht Ashoori; Kensuke Suzuki; Yosuke Tokumaru; Naoko Ikuta; Masaki Tajima; Tasuku Honjo; Akio Ohta

  Frontiers in immunology, 2020, Peer-reviewed

  
• RICK/RIP2 is a NOD2-independent nodal point of gut inflammation.

  Tomohiro Watanabe; Kosuke Minaga; Ken Kamata; Toshiharu Sakurai; Yoriaki Komeda; Tomoyuki Nagai; Atsushi Kitani; Masaki Tajima; Ivan J Fuss; Masatoshi Kudo; Warren Strober

  International immunology, 18 Sep. 2019, Peer-reviewed

  
• An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.

  Tetsuya Takagawa; Atsushi Kitani; Ivan Fuss; Beth Levine; Steven R Brant; Inga Peter; Masaki Tajima; Shiro Nakamura; Warren Strober

  Science translational medicine, 06 Jun. 2018, Peer-reviewed

  
• Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.

  Yasuyuki Arai; Uimook Choi; Cristina I Corsino; Sherry M Koontz; Masaki Tajima; Colin L Sweeney; Mary A Black; Steven A Feldman; Mary C Dinauer; Harry L Malech

  Molecular therapy : the journal of the American Society of Gene Therapy, 02 May 2018, Peer-reviewed

  
• The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.

  Takayuki Satoh; Masaki Tajima; Daiko Wakita; Hidemitsu Kitamura; Takashi Nishimura

  European journal of immunology, Sep. 2012, Peer-reviewed, Lead author

  
• IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.

  Masaki Tajima; Daiko Wakita; Takayuki Satoh; Hidemitsu Kitamura; Takashi Nishimura

  International immunology, Dec. 2011, Peer-reviewed, Lead author

  
• Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen.

  Daisuke Noguchi; Daiko Wakita; Takayuki Ohkuri; Masaki Tajima; Kenji Chamoto; Hidemitsu Kitamura; Takashi Nishimura

  Immunology letters, May 2011, Peer-reviewed

  
• IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.

  Masaki Tajima; Daiko Wakita; Daisuke Noguchi; Kenji Chamoto; Zhang Yue; Kazunori Fugo; Harumichi Ishigame; Yoichiro Iwakura; Hidemitsu Kitamura; Takashi Nishimura

  The Journal of experimental medicine, 12 May 2008, Peer-reviewed, Lead author

  
• Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner.

  Daisuke Noguchi; Daiko Wakita; Masaki Tajima; Shigeru Ashino; Yoichiro Iwakura; Yue Zhang; Kenji Chamoto; Hidemitsu Kitamura; Takashi Nishimura

  International immunology, Dec. 2007, Peer-reviewed

  

Presentations

• Metabolic stress causes persistent susceptibility to ferroptosis in CD8 T cells

  Masaki Tajima

  Kyoto University CCII-China Medical University Joint Mini-symposium, 19 May 2025, Invited

  
• 新たな免疫疾患治療法の開発に向けたPD-1アゴニスト抗体の創薬戦略

  但馬正樹

  第34回日本リウマチ学会近畿支部学術集会, 23 Sep. 2025, Invited

  
• 代謝ストレスの刷り込みが免疫細胞のフェロプトーシス感受性に与える時空間的影響

  但馬正樹

  生理研研究会 病気につながる血管周囲の微小炎症を標的とする量子技術、ニューロモデュレーション医療による未病時治療法の開発, 29 Nov. 2024, Invited

  
• Past history of high-fat diet causes persistent susceptibility to ferroptosis in CD8 T cells

  Masaki Tajima

  1st CCII International Symposium on Immunotherapy and Immunobiology, 14 Nov. 2024, Invited

  
• PD-1シグナルを活性化するアゴニスト抗体による免疫制御法の開発

  但馬正樹

  生理研 村上ムーンショット研究会, 27 Oct. 2023, Invited

  

Books and Other Publications

• PD-1 をターゲットとした免疫治療への挑戦

  但馬正樹; 太田明夫; 茶本健司, Joint work

  炎症と免疫, 20 Oct. 2023

  
• 新しい細胞傷害性T細胞のサブセット Tc17/IFN-γの産生制御機構と疾病における役割

  佐藤崇之; 但馬正樹; 北村秀光; 西村孝司, Joint work

  臨床免疫・アレルギー科, 2013

  
• 自己免疫性大腸炎におけるIL-17産生CD8+ T細胞の役割

  但馬正樹; 西村孝司, Joint work

  Medical Science Digest, 2010

  
• 活性型ビタミンD3とall-transレチノイン酸(ATRA)によるTh17細胞の分化制御とその免疫病治療への応用

  池田詩子; 但馬正樹; 芦野滋; 脇田大功; 北村秀光; 西村孝司, Joint work

  臨床免疫・アレルギー科, 2010

  

Industrial Property Rights

• 特開WO/2022/239820, 特願PCT/JP2022/020011, 炎症性疾患を治療又は予防するための抗ヒトPD-1アゴニスト抗体及びこれを含有する医薬組成物

  本庶 佑; 太田 明夫; 但馬 正樹; 鎌田 春彦; 永田 諭志; 鈴木 健介; 福島 崇恵; 徳丸 陽介

  
• 特開WO/2021/241523, 特願PCT/JP2021/019676, PD-1 AGONIST-CONTAINING PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING Th2-MEDIATED DISEASE

  本庶 佑、太田 明夫、但馬 正樹、鎌田 春彦、永田 諭志、鈴木 健介、大城 裕也、徳丸 陽介

  

External funds: Kakenhi

• Evaluation of Tr2 cells to maximize the efficiency of PD-1 blockade in tumor immunity

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University;Foundation for Biomedical Research and Innovation at Kobe

  Masaki Tajima

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  腫瘍免疫;免疫代謝;IL-10;Dectin-1;グルタミン代謝;免疫チェックポイント阻害;免疫関連副作用;1型糖尿病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16881/
• Spatiotemporal Effect of Metabolic Imprinting on Immune System

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  但馬 正樹

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  腫瘍免疫;代謝ストレス;核酸代謝;オミックス;メタボローム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10092/