Basic Information

Faculty

• 医学部

Academic Degree

• 修士（医科学）(北海道大学)
• 博士（医学）(北海道大学)

Research History

• From Apr. 2019, To Dec. 2020

  Foundation for Biomedical Research and Innovation, Institute for Biomedical Research and Innovation, Senior Investigator
• From Jun. 2017, To Dec. 2020

  Kyoto University, Graduate School of Medicine, Assistant Professor
• From Jun. 2017, To Mar. 2019

  Foundation for Biomedical Research and Innovation, Institute of Biomedical Research and Innovation, Researcher
• From May 2012, To May 2017

  National Institutes for Health, National Institute of Allergy and Infectious Diseases, Visiting fellow
• From Jan. 2014, To Dec. 2015

  National Institutes of Health, National Institute of Allergy and Infectious Diseases, Postdoctoral Fellowships of Japan Society for the Promotion of Science (NIH)
• From Apr. 2009, To Mar. 2012

  Hokkaido University, Graduate School of Medicine, JSPS Research Fellowship for Young Scientists

ID,URL

• J-Global ID

  202001001580073436

• Researcher number

  50815032

researchmap URL

• https://researchmap.jp/masakitajima

Research

Research Interests

• Oncology
• Metabolism
• Immunology

Papers

• Spermidine – an old molecule with a new age-defying immune function

  Kenji Chamoto; Baihao Zhang; Masaki Tajima; Tasuku Honjo; Sidonia Fagarasan

  Trends in Cell Biology, Sep. 2023

  
• Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

  Kenji Chamoto; Tomonori Yaguchi; Masaki Tajima; Tasuku Honjo

  Nature Reviews Immunology, 25 Apr. 2023, Peer-reviewed, Lead author

  
• Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases.

  Kensuke Suzuki; Masaki Tajima; Yosuke Tokumaru; Yuya Oshiro; Satoshi Nagata; Haruhiko Kamada; Miho Kihara; Kohei Nakano; Tasuku Honjo; Akio Ohta

  Science immunology, 13 Jan. 2023, Peer-reviewed, Lead author

  
• Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

  Muna Al-Habsi; Kenji Chamoto; Ken Matsumoto; Norimichi Nomura; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Aprilia Maharani; Yuka Nakajima; Yibo Wu; Yayoi Nomura; Rosemary Menzies; Masaki Tajima; Koji Kitaoka; Yasuharu Haku; Sara Delghandi; Keiko Yurimoto; Fumihiko Matsuda; So Iwata; Toshihiko Ogura; Sidonia Fagarasan; Tasuku Honjo

  Science, 28 Oct. 2022, Peer-reviewed

  
• Evaluation of Glutaminolysis in T Cells.

  Masaki Tajima; Warren Strober

  Current protocols, Sep. 2022, Peer-reviewed, Lead author

  
• STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T-cell sensitivity to PD-1-dependent immunoregulation.

  Guanning Wang; Masaki Tajima; Tasuku Honjo; Akio Ohta

  International immunology, 29 Oct. 2021, Peer-reviewed

  
• Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events.

  Matin Dokht Ashoori; Kensuke Suzuki; Yosuke Tokumaru; Naoko Ikuta; Masaki Tajima; Tasuku Honjo; Akio Ohta

  Frontiers in immunology, 2020, Peer-reviewed

  
• RICK/RIP2 is a NOD2-independent nodal point of gut inflammation.

  Tomohiro Watanabe; Kosuke Minaga; Ken Kamata; Toshiharu Sakurai; Yoriaki Komeda; Tomoyuki Nagai; Atsushi Kitani; Masaki Tajima; Ivan J Fuss; Masatoshi Kudo; Warren Strober

  International immunology, 18 Sep. 2019, Peer-reviewed

  
• An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.

  Tetsuya Takagawa; Atsushi Kitani; Ivan Fuss; Beth Levine; Steven R Brant; Inga Peter; Masaki Tajima; Shiro Nakamura; Warren Strober

  Science translational medicine, 06 Jun. 2018, Peer-reviewed

  
• Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.

  Yasuyuki Arai; Uimook Choi; Cristina I Corsino; Sherry M Koontz; Masaki Tajima; Colin L Sweeney; Mary A Black; Steven A Feldman; Mary C Dinauer; Harry L Malech

  Molecular therapy : the journal of the American Society of Gene Therapy, 02 May 2018, Peer-reviewed

  
• The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.

  Takayuki Satoh; Masaki Tajima; Daiko Wakita; Hidemitsu Kitamura; Takashi Nishimura

  European journal of immunology, Sep. 2012, Peer-reviewed, Lead author

  
• IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.

  Masaki Tajima; Daiko Wakita; Takayuki Satoh; Hidemitsu Kitamura; Takashi Nishimura

  International immunology, Dec. 2011, Peer-reviewed, Lead author

  
• Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen.

  Daisuke Noguchi; Daiko Wakita; Takayuki Ohkuri; Masaki Tajima; Kenji Chamoto; Hidemitsu Kitamura; Takashi Nishimura

  Immunology letters, May 2011, Peer-reviewed

  
• IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.

  Masaki Tajima; Daiko Wakita; Daisuke Noguchi; Kenji Chamoto; Zhang Yue; Kazunori Fugo; Harumichi Ishigame; Yoichiro Iwakura; Hidemitsu Kitamura; Takashi Nishimura

  The Journal of experimental medicine, 12 May 2008, Peer-reviewed, Lead author

  
• Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner.

  Daisuke Noguchi; Daiko Wakita; Masaki Tajima; Shigeru Ashino; Yoichiro Iwakura; Yue Zhang; Kenji Chamoto; Hidemitsu Kitamura; Takashi Nishimura

  International immunology, Dec. 2007, Peer-reviewed

  

Industrial Property Rights

• 特開WO/2022/239820, 特願PCT/JP2022/020011, 炎症性疾患を治療又は予防するための抗ヒトPD-1アゴニスト抗体及びこれを含有する医薬組成物

  本庶 佑; 太田 明夫; 但馬 正樹; 鎌田 春彦; 永田 諭志; 鈴木 健介; 福島 崇恵; 徳丸 陽介

  
• 特開WO/2021/241523, 特願PCT/JP2021/019676, PD-1 AGONIST-CONTAINING PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING Th2-MEDIATED DISEASE

  本庶 佑、太田 明夫、但馬 正樹、鎌田 春彦、永田 諭志、鈴木 健介、大城 裕也、徳丸 陽介

  

External funds: Kakenhi

• Evaluation of Tr2 cells to maximize the efficiency of PD-1 blockade in tumor immunity

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University;Foundation for Biomedical Research and Innovation at Kobe

  Masaki Tajima

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  腫瘍免疫;免疫代謝;IL-10;Dectin-1;グルタミン代謝;免疫チェックポイント阻害;免疫関連副作用;1型糖尿病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16881/
• Spatiotemporal Effect of Metabolic Imprinting on Immune System

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  但馬 正樹

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  腫瘍免疫;代謝ストレス;オミックス;メタボローム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10092/