Basic Information

Academic Degree

• 30 Nov. 2008

  筑波大学博士（行動科学）

Academic Resume (Undergraduate School/Majors)

• 筑波大学, 第二学群人間学類心理学専攻, 卒業

Research History

• From Sep. 2023, To Present

  Kyoto University, 大学院医学研究科附属動物実験施設, 特定講師
• From Apr. 2019, To Aug. 2023

  Waseda University, Faculty of Human Sciences, 講師
• From Aug. 2011, To Mar. 2019

  Gunma University, 大学院医学系研究科, Assistant Professor
• From Dec. 2008, To Jul. 2011

  The University of Tokyo, 大学院医学系研究科疾患生命工学センター健康環境医工学部門, 特任研究員

ID,URL

• J-Global ID

  201601013819708965

researchmap URL

• https://researchmap.jp/7000016468

Research

Papers

• Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice.

  Ayane Ninomiya; Izuki Amano; Hiraku Suzuki; Yuki Fujiwara; Asahi Haijima; Noriyuki Koibuchi

  The journal of physiological sciences : JPS, 05 Mar. 2024

  
• Motor coordination is partially impaired in neonatal mice with moderate hypothyroidism but not with mild hypothyroidism

  Michifumi Kokubo; Izuki Amano; Hiroyuki Yajima; Wataru Miyazaki; Yusuke Takatsuru; Asahi Haijima; Shogo Haraguchi; Noriyuki Koibuchi

  Thyroid Science, Feb. 2024

  
• The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice.

  Ayane Ninomiya; Abdallah Mshaty; Asahi Haijima; Hiroyuki Yajima; Michifumi Kokubo; Miski Aghnia Khairinisa; Winda Ariyani; Yuki Fujiwara; Sumiyasu Ishii; Nobutake Hosoi; Hirokazu Hirai; Izuki Amano; Noriyuki Koibuchi

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Jan. 2022, Peer-reviewed

  
• Neurotoxic effects of lactational exposure to perfluorooctane sulfonate on learning and memory in adult male mouse

  Abdallah Mshaty; Asahi Haijima; Yusuke Takatsuru; Ayane Ninomiya; Hiroyuki Yajima; Michifumi Kokubo; Miski Aghnia Khairinisa; Wataru Miyazaki; Izuki Amano; Noriyuki Koibuchi

  Food and Chemical Toxicology, Nov. 2020, Peer-reviewed, Corresponding author

  
• A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development

  Shin‐ichiro Horigane; Yukihiro Ozawa; Jun Zhang; Hiroe Todoroki; Pan Miao; Asahi Haijima; Yuchio Yanagawa; Shuhei Ueda; Shigeo Nakamura; Masaki Kakeyama; Sayaka Takemoto‐Kimura

  FEBS Open Bio, 19 Jul. 2020, Peer-reviewed

  
• In utero and postnatal propylthiouracil-induced mild hypothyroidism impairs maternal behavior in mice

  Miski Aghnia Khairinisa; Yusuke Takatsuru; Izuki Amano; Michifumi Kokubo; Asahi Haijima; Wataru Miyazaki; Noriyuki Koibuchi

  Frontiers in Endocrinology, 14 May 2018, Peer-reviewed

  
• Early-life stress induces cognitive disorder in middle-aged mice

  Hiroyuki Yajima; Asahi Haijima; Miski Aghnia Khairinisa; Noriaki Shimokawa; Izuki Amano; Yusuke Takatsuru

  Neurobiology of Aging, 01 Apr. 2018, Peer-reviewed

  
• Inhibitory neuron-specific Cre-dependent red fluorescent labeling using VGAT BAC-based transgenic mouse lines with identified transgene integration sites

  Ryosuke Kaneko; Yusuke Takatsuru; Ayako Morita; Izuki Amano; Asahi Haijima; Itaru Imayoshi; Nobuaki Tamamaki; Noriyuki Koibuchi; Masahiko Watanabe; Yuchio Yanagawa

  Journal of Comparative Neurology, 15 Feb. 2018, Peer-reviewed

  
• Effects of Mild Perinatal Hypothyroidism on Cognitive Function of Adult Male Offspring

  Amano, Izuki; Takatsuru, Yusuke; Khairinisa; Miski Aghnia; Kokubo, Michifumi; Haijima, Asahi; Koibuchi, Noriyuki

  ENDOCRINOLOGY, 2018, Peer-reviewed

  
• Differential neurotoxic effects of in utero and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mice

  Asahi Haijima; Ronny Lesmana; Noriaki Shimokawam; Izuki Amano; Yusuke Takatsuru; Noriyuki Koibuchi

  JOURNAL OF TOXICOLOGICAL SCIENCES, Aug. 2017, Peer-reviewed, Lead author, Corresponding author

  
• Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors

  Izuki Amano; Yusuke Takatsuru; Syutaro Toya; Asahi Haijima; Toshiharu Iwasaki; Helmut Grasberger; Samuel Refetoff; Noriyuki Koibuchi

  THYROID, May 2016, Peer-reviewed

  
• The role of the retrosplenial cortex and hippocampus in long-term memory in rats

  蓜島 旭; 一谷 幸男

  行動科学, 2016, Peer-reviewed, Lead author, Corresponding author

  
• Altered Cerebellum Development and Dopamine Distribution in a Rat Genetic Model with Congenital Hypothyroidism

  N. Shimokawa; B. Yousefi; S. Morioka; S. Yamaguchi; A. Ohsawa; H. Hayashi; A. Azuma; H. Mizuno; M. Kasagi; H. Masuda; H. Jingu; S. -I. Furudate; A. Haijima; Y. Takatsuru; T. Iwasaki; M. Umezu; N. Koibuchi

  JOURNAL OF NEUROENDOCRINOLOGY, Mar. 2014, Peer-reviewed

  
• Fluorescence laser microdissection reveals a distinct pattern of gene activation in the mouse hippocampal region

  Wataru Yoshioka; Nozomi Endo; Akie Kurashige; Asahi Haijima; Toshihiro Endo; Toshiyuki Shibata; Ryutaro Nishiyama; Masaki Kakeyama; Chiharu Tohyama

  SCIENTIFIC REPORTS, Nov. 2012, Peer-reviewed

  
• Dissociable anterograde amnesic effects of retrosplenial cortex and hippocampal lesions on spontaneous object recognition memory in rats

  Asahi Haijima; Yukio Ichitani

  HIPPOCAMPUS, Sep. 2012, Peer-reviewed

  
• Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.

  Endo T; Kakeyama M; Uemura Y; Haijima A; Okuno H; Bito H; Tohyama C

  Plos One, 2012, Peer-reviewed

  
• Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

  Toshihiro Endo; Fumihiko Maekawa; Vootele Voikar; Asahi Haijima; Yukari Uemura; Yan Zhang; Wataru Miyazaki; Shigetomo Suyama; Kuniko Shimazaki; David P. Wolfer; Toshihiko Yada; Chiharu Tohyama; Hans-Peter Lipp; Masaki Kakeyama

  BEHAVIOURAL BRAIN RESEARCH, Aug. 2011, Peer-reviewed

  
• Development of novel behavioral toxicity tests in rodents aimed for application to health risks in humans.

  Kakeyama M; Haijima A; Endo T; Tohyama C

  The Japanese Journal of Animal Psychology, 2011, Peer-reviewed

  
• In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice

  Asahi Haijima; Toshihiro Endo; Yan Zhang; Wataru Miyazaki; Masaki Kakeyama; Chiharu Tohyama

  NEUROTOXICOLOGY, Aug. 2010, Peer-reviewed

  
• Perinatal exposure to a low-dose of dioxin induces deficits in fear conditioning in mice.

  Haijima A; Endo T; Zhang Y; Kakeyama M; Tohyama C

  Organohalogen Compounds, 2009

  
• Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats

  Asahi Haijima; Yukio Ichitani

  LEARNING & MEMORY, Jul. 2008, Peer-reviewed

  

Misc.

• 運動神経発達に対する甲状腺ホルモンの役割

  小久保 倫文; 高鶴 裕介; 天野 出月; 蓜島 旭; 鯉淵 典之

  The Kitakanto medical journal = 北関東医学, 01 Aug. 2015

  

External funds: Kakenhi

• Elucidation of the mechanism of brain dysfunction caused by perinatal environmental chemicals exposure and development of methods to prevent and control the disorder

  Grant-in-Aid for Scientific Research (B)

  Basic Section 63030:Chemical substance influence on environment-related

  Hirosaki University

  Wataru Miyazaki

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  エピゲノム;環境化学物質;周産期曝露;脳発達;miRNA;エピジェネティクス;メタボローム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H04339/
• Retrieval induced forgetting in mice

  Grant-in-Aid for Scientific Research (C)

  Basic Section 10040:Experimental psychology-related

  Waseda University;Gunma University

  Asahi Haijima

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  検索誘導性忘却;記憶;マウス;物体再認記憶試験

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K03169/
• Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development.

  Grant-in-Aid for Scientific Research (B)

  Basic Section 63030:Chemical substance influence on environment-related

  Gunma University

  Noriyuki Koibuchi

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  内分泌かく乱;甲状腺ホルモン;脳発達;内分泌かく乱化学物質;エピゲノム;エストロゲン;核内受容体;遺伝子発現;エピジェネティック

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03379/
• Effects of environmental factors on small lipophilic hormone-mediated development of brain function

  Grant-in-Aid for Scientific Research (B)

  Gunma University

  Noriyuki Koibuchi

  From 01 Apr. 2013, To 31 Mar. 2017, Project Closed

  核内受容体;脳発達;脂溶性ホルモン;内分泌撹乱化学物質;環境因子;甲状腺ホルモン;グルココルチコイド;内分泌かく乱;内分泌かく乱化学物質;ホルモン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25281024/
• Developmental neurotoxic effects of perinatal exposure to flame retardants on the behavior of adult male mouse offspring

  Grant-in-Aid for Young Scientists (B)

  Gunma University

  ASAHI HAIJIMA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  発達神経毒性;PFOS;行動試験;授乳期曝露;周産期曝露

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710068/
• 終脳特異的なガングリオシド欠損が脳発達に及ぼす影響の解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  配島 旭

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  ガングリオシド;脳発達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09298/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Animal Science

  8030, Spring, Faculty of Medicine, 1