Basic Information

Faculty

• 医学部

Academic Degree

• 博士（医学）(東京大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院医学研究科博士課程病因・病理学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 群馬大学, 医学部医学科, 卒業

ID,URL

• J-Global ID

  201401042855785784

researchmap URL

• https://researchmap.jp/7000008668

Research

Research Topics, Overview of the research

• Research Topics

  Molecular mechanisms of genome maintenance, molecular carcinogenesis, and a molecular basis of cancer precision medicine
  

• Overview of the research

  Cells possess mechanisms that sense and respond to various types of DNA damage in the genome. Such mechanisms, collectively called DNA damage response (DDR), are not only the major barriers but also the mediators of pathogenic mutations. My research focuses on uncovering the molecular mechanisms of genome maintenance and thereby facilitating understanding of the molecular carcinogenesis steps and providing a basis for cancer precision medicine.
  

Research Areas

• Life sciences, Molecular biology

Papers

• クロマチンリモデリング因子BAZ1A/ACF1は、MLL1依存的にUV損傷部位を標的としてヌクレオチド除去修復を促進する(Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate NER)

  丹伊田 浩行; 小谷内 敬史; 茂木 章; 酒井 聡; 内田 千晴; 大畑 達也; 飯島 健太; 横山 明彦; 須田 隆文; 北川 雅敏

  日本癌学会総会記事, Sep. 2022

  
• Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair.

  Takafumi Koyauchi; Hiroyuki Niida; Akira Motegi; Satoshi Sakai; Chiharu Uchida; Tatsuya Ohhata; Kenta Iijima; Akihiko Yokoyama; Takafumi Suda; Masatoshi Kitagawa

  Biochimica et biophysica acta. Molecular cell research, 05 Aug. 2022

  
• HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation.

  Koji Nishimoto; Hiroyuki Niida; Chiharu Uchida; Tatsuya Ohhata; Kyoko Kitagawa; Akira Motegi; Takafumi Suda; Masatoshi Kitagawa

  Molecular cancer research : MCR, 11 Jun. 2020, Peer-reviewed

  
• Aberrations in DNA repair pathways in cancer and therapeutic significances.

  Motegi A; Masutani M; Yoshioka KI; Bessho T

  Seminars in cancer biology, Mar. 2019, Peer-reviewed

  
• Erratum: Author Correction: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair (Nature communications (2017) 8 (16102))

  Niida H; Matsunuma R; Horiguchi R; Uchida C; Nakazawa Y; Motegi A; Nishimoto K; Sakai S; Ohhata T; Kitagawa K; Moriwaki S; Nishitani H; Ui A; Ogi T; Kitagawa M

  Nature communications, 2018, Peer-reviewed

  
• PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice

  Ayako L. Mochizuki; Ami Katanaya; Eri Hayashi; Mihoko Hosokawa; Emiko Moribe; Akira Motegi; Masamichi Ishiai; Minoru Takata; Gen Kondoh; Hitomi Watanabe; Norio Nakatsuji; Shinichiro Chuma

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2017, Peer-reviewed

  
• Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair

  Hiroyuki Niida; Ryoichi Matsunuma; Ryo Horiguchi; Chiharu Uchida; Yuka Nakazawa; Akira Motegi; Koji Nishimoto; Satoshi Sakai; Tatsuya Ohhata; Kyoko Kitagawa; Shinichi Moriwaki; Hideo Nishitani; Ayako Ui; Tomoo Ogi; Masatoshi Kitagawa

  NATURE COMMUNICATIONS, Jul. 2017, Peer-reviewed

  
• Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors

  Junhui Wang; Qianshan Ding; Hiroaki Fujimori; Akira Motegi; Yoshio Miki; Mitsuko Masutani

  ONCOTARGET, Feb. 2016, Peer-reviewed

  
• Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining

  S. Kobayashi; Y. Kasaishi; S. Nakada; T. Takagi; S. Era; A. Motegi; R. K. Chiu; S. Takeda; K. Hirota

  ONCOGENE, Aug. 2015, Peer-reviewed

  
• Third Report on Chicken Genes and Chromosomes 2015

  Michael Schmid; Jacqueline Smith; David W. Burt; Bronwen L. Aken; Parker B. Antin; Alan L. Archibald; Chris Ashwell; Perry J. Blackshear; Clarissa Boschiero; C. Titus Brown; Shane C. Burgess; Hans H. Cheng; William Chow; Derrick J. Coble; Amanda Cooksey; Richard P. M. A. Crooijmans; Joana Damas; Richard V. N. Davis; Dirk-Jan de Koning; Mary E. Delany; Thomas Derrien; Takele T. Desta; Ian C. Dunn; Matthew Dunn; Hans Ellegren; Lel Eoery; Ionas Erb; Marta Farre; Mario Fasold; Damarius Fleming; Paul Flicek; Katie E. Fowler; Laure Fresard; David P. Froman; Valerie Garceau; Paul P. Gardner; Almas A. Gheyas; Darren K. Griffin; Martien A. M. Groenen; Thomas Haaf; Olivier Hanotte; Alan Hart; Julien Haesler; S. Blair Hedges; Jana Hertel; Kerstin Howe; Allen Hubbard; David A. Hume; Pete Kaiser; Darek Kedra; Stephen J. Kemp; Christophe Klopp; Kalmia E. Kniel; Richard Kuo; Sandrine Lagarrigue; Susan J. Lamont; Denis M. Larkin; Raman A. Lawal; Sarah M. Markland; Fiona McCarthy; Heather A. McCormack; Marla C. McPherson; Akira Motegi; Stefan A. Muljo; Andrea Muensterberg; Rishi Nag; Indrajit Nanda; Michael Neuberger; Anne Nitsche; Cedric Notredame; Harry Noyes; Rebecca O'Connor; Elizabeth A. O'Hare; Andrew J. Oler; Sheila C. Ommeh; Helio Pais; Michael Persia; Frederique Pitel; Likit Preeyanon; Pablo Prieto Barja; Elizabeth M. Pritchett; Douglas D. Rhoads; Charmaine M. Robinson; Michael N. Romanov; Max Rothschild; Pierre-Francois Roux; Carl J. Schmidt; Alisa-Sophia Schneider; Matthew G. Schwartz; Steve M. Searle; Michael A. Skinner; Craig A. Smith; Peter F. Stadler; Tammy E. Steeves; Claus Steinlein; Liang Sun; Minoru Takata; Igor Ulitsky; Qing Wang; Ying Wang; Wesley C. Warren; Jonathan M. D. Wood; David Wragg; Huaijun Zhou

  CYTOGENETIC AND GENOME RESEARCH, 2015, Peer-reviewed

  
• Multiple genetic manipulations of DT40 cell line

  Akira Motegi; Minoru Takata

  Methods in Molecular Biology, 01 Jan. 2014, Peer-reviewed

  
• The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment

  Saho Era; Takuya Abe; Hiroshi Arakawa; Shunsuke Kobayashi; Barnabas Szakal; Yusuke Yoshikawa; Akira Motegi; Shunichi Takeda; Dana Branzei

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2012, Peer-reviewed

  
• Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

  Susanne M. Germann; Vibe H. Oestergaard; Caroline Haas; Pauline Salis; Akira Motegi; Michael Lisby

  DNA REPAIR, Feb. 2011, Peer-reviewed

  
• Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.

  Kouji Hirota; Eiichiro Sonoda; Takuo Kawamoto; Akira Motegi; Chikahide Masutani; Fumio Hanaoka; Dávid Szüts; Shigenori Iwai; Julian E Sale; Alan Lehmann; Shunichi Takeda

  PLoS genetics, 07 Oct. 2010, Peer-reviewed

  Access this paper :

  
• Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions

  Kouji Hirota; Eiichiro Sonoda; Takuo Kawamoto; Akira Motegi; Chikahide Masutani; Fumio Hanaoka; David Szuets; Shigenori Iwai; Julian E. Sale; Alan Lehmann; Shunichi Takeda

  PLOS GENETICS, Oct. 2010, Peer-reviewed

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• The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy

  Akira Motegi; Yasuhiro Murakawa; Shunichi Takeda

  CANCER LETTERS, Sep. 2009, Peer-reviewed

  
• [Function of homologous recombination-mediated DNA repair].

  A. Motegi; S. Takeda

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2009, Peer-reviewed

  
• Maintenance of genome stability though ubcl3-dependent ubiquitination

  Akira Motegi

  Seikagaku, 2009, Peer-reviewed

  
• Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

  Akira Motegi; Hung-Jiun Liaw; Kyoo-Young Lee; Henk P. Roest; Alex Maas; Xiaoli Wu; Helen Moinova; Sanford D. Markowitz; Hao Ding; Jan H. J. Hoeijmakers; Kyungjae Myung

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2008, Peer-reviewed

  
• Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination

  Soma Banerjee; Stephanie Smith; Ji-Hyun Oum; Hung-Jiun Liaw; Ji-Young Hwang; Nilabja Sikdar; Akira Motegi; Sang Eun Lee; Kyungjae Myung

  JOURNAL OF CELL BIOLOGY, Jun. 2008, Peer-reviewed

  
• Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer

  Akira Motegi; Kyungjae Myung

  METHODS, Feb. 2007, Peer-reviewed

  
• Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164SUMOylation and ubiquitination

  Clark C. Chen; Akira Motegi; Yuko Hasegawa; Kyungjae Myung; Richard Kolodner; Alan D'Andrea

  DNA REPAIR, Dec. 2006, Peer-reviewed

  
• Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

  Akira Motegi; Raman Sood; Helen Moinova; Sanford D. Markowitz; Pu Paul Liu; Kyungjae Myung

  JOURNAL OF CELL BIOLOGY, Dec. 2006, Peer-reviewed

  
• Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae

  A Motegi; K Kuntz; A Majeed; S Smith; K Myung

  MOLECULAR AND CELLULAR BIOLOGY, Feb. 2006, Peer-reviewed

  
• Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways

  Clark Chen; Akira Motegi; Yuko Hasegawa; Richard Kolodner; Kyungjae Myung; Alan D’Andrea

  DNA Repair 5:1475-1488 (2006), 2006, Peer-reviewed

  
• ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

  A Motegi; J Fujimoto; M Kotani; H Sakuraba; T Yamamoto

  JOURNAL OF CELL SCIENCE, Jul. 2004, Peer-reviewed

  
• PRAC2: A new gene expressed in human prostate and prostate cancer

  P Olsson; A Motegi; TK Bera; B Lee; Pastan, I

  PROSTATE, Jul. 2003, Peer-reviewed

  

Misc.

• NAD+-poly(ADP-ribose)代謝を標的とした創薬研究の新展開 基礎から臨床応用まで PARP-1及びPARGはDNA二本鎖切断末端のリゼクション制御によりゲノム安定性を促進する

  茂木 章; Wang Junhui; 藤森 浩彰; 三木 義男; 益谷 美都子

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• PARP-1とPARGは放射線応答において53BP1の制御に関与する(PARP-1 and PARG are both required for the regulation of 53BP1 after IR)

  Wang Junhui; 茂木 章; 藤森 浩彰; 三木 義男; 益谷 美都子

  日本癌学会総会記事, Sep. 2014

  
• PARP-1は5'-及び3'-ブロック2本鎖切断端からのCtIPが関与する過剰なエンドリセクションを抑制する(PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP)

  Wang Junhui; 茂木 章; 藤森 浩彰; 三木 義男; 益谷 美都子

  日本癌学会総会記事, Oct. 2013

  
• 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」

  足立淳; 鳴海良平; 佐野聖三; 久家貴寿; 白水崇; 松本雅記; 中山敬一; 茂木章; 井倉毅; 高田穣; 朝長毅

  第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月, 2010, Peer-reviewed

  
• ユビキチン化によるDNA修復の制御機構

  茂木章; 村川泰裕; 武田俊一

  実験医学, 2008

  
• ユビキチン化によるDNA修復の制御機構

  茂木章; 村川泰裕; 武田俊一

  細胞工学, 2007

  

Awards

• 2005

  2005 Keystone Symposia Scholarship Award

External funds: Kakenhi

• English title

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akira Motegi

  From 01 Apr. 2017, To 31 Mar. 2022, Project Closed

  DNA損傷トレランス;複製後修復;相同組換え;ユビキチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K00548/
• Analysis of DNA-damage-tolerance mechanisms that facilitate restart of stalled DNA replication

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  AKIRA MOTEGI

  From 01 Apr. 2013, To 31 Mar. 2017, Project Closed

  DNA損傷トレランス;複製後修復;組換え修復;ユビキチン;相同組換え;DNA修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25340030/
• Analysis of regulatory mechanisms of DNA repair by ubiquitination

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akira MOTEGI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  DNA修復;複製後修復;相同組換え;ユビキチン;Rad5

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22510059/
• Analysis of DNA damage response using gene-disrupted DT40 clones.

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Shunichi TAKEDA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  DNA組換え;標的組換え;遺伝子治療;DT40;ニワトリBリンパ細胞;DNA組み換え;標的組み換え;DNA修復;変異;化審法;有害化学物質;ハイスループットスクリーニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20241012/
• Ubiquitin-dependent regulation of DNA replication arrest

  Grant-in-Aid for Young Scientists (Start-up)

  Kyoto University

  Akira MOTEGI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  組換え修復;複製後修復;ユビキチン化;組み替え修復;組替え修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19810007/

Administration

School management (title, position)

• 京都大学無機廃液処理装置（KMS）指導員
• エネルギー管理要員
• From 01 Apr. 2017, To 31 Mar. 2019

  放射線障害予防小委員会

Faculty management (title, position)

• To 31 Mar. 2019

  医学図書館連絡委員
• 放射線障害防止委員会