Basic Information

Professional Memberships

• Society for Neuroscience
• 日本分子生物学会
• Society for Neuroscience

Academic Degree

• 博士（理学）(東京大学)

Research History

• The University of Tokyo The Institute of Medical Science, Division of Oncology, Division of Oncology, Department of Cancer Biology, Div. Genetics, Inst. Med Sci., Univ. Tokyo

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  200901064796827366

researchmap URL

• https://researchmap.jp/read0213396

Research

Research Topics, Overview of the research

• Research Topics

  Roles and mechanism of the ubiquitination system

• Overview of the research

  Many proteins are involved in protein ubiquitination events, but roles of these proteins are not well understood. I will elucidate the mechanisms underlying various physiological functions through the analysis of ubiquitination-related proteins.

Research Interests

• 神経系
• ユビキチン化
• チロシンキナーゼ
• Tyrosine kinase

Research Areas

• Life sciences, Cell biology
• Life sciences, Functional biochemistry
• Life sciences, Neuroscience - general

Papers

• DOK7 gene therapy enhances motor activity and life span in ALS model mice

  Sadanori Miyoshi; Tohru Tezuka; Sumimasa Arimura; Taro Tomono; Takashi Okada; Yuji Yamanashi

  EMBO MOLECULAR MEDICINE, Jul. 2017, Peer-reviewed

  
• The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation

  Ryo Ueta; Tohru Tezuka; Yosuke Izawa; Sadanori Miyoshi; Satoru Nagatoishi; Kouhei Tsumoto; Yuji Yamanashi

  JOURNAL OF BIOCHEMISTRY, Mar. 2017, Peer-reviewed

  
• [Molecular mechanisms underlying the formation and maintenance of neuromuscular junctions and a possible therapeutic approach.]

  Eguchi T; Tezuka T; Miyoshi S; Yamanashi Y

  Clinical calcium, 2017, Peer-reviewed

  
• Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology

  Takahiro Eguchi; Tohru Tezuka; Sadanori Miyoshi; Yuji Yamanashi

  GENES TO CELLS, Jun. 2016, Peer-reviewed

  
• The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses

  Tohru Tezuka; Akane Inoue; Taisuke Hoshi; Scott D. Weatherbee; Robert W. Burgess; Ryo Ueta; Yuji Yamanashi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2014, Peer-reviewed

  
• DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction

  Sumimasa Arimura; Takashi Okada; Tohru Tezuka; Tomoko Chiyo; Yuko Kasahara; Toshiro Yoshimura; Masakatsu Motomura; Nobuaki Yoshida; David Beeson; Shin'ichi Takeda; Yuji Yamanashi

  SCIENCE, Sep. 2014, Peer-reviewed

  
• Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes

  Taisuke Hoshi; Tohru Tezuka; Kazumasa Yokoyama; Shun-Ichiro Iemura; Tohru Natsume; Yuji Yamanashi

  FEBS Letters, 29 Nov. 2013, Peer-reviewed

  
• Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits

  Naosuke Hoshina; Asami Tanimura; Miwako Yamasaki; Takeshi Inoue; Ryoji Fukabori; Teiko Kuroda; Kazumasa Yokoyama; Tohru Tezuka; Hiroshi Sagara; Shinji Hirano; Hiroshi Kiyonari; Masahiko Takada; Kazuto Kobayashi; Masahiko Watanabe; Masanobu Kano; Takanobu Nakazawa; Tadashi Yamamoto

  NEURON, Jun. 2013, Peer-reviewed

  
• Adaptor protein complex of FRS2 beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation

  Yuriko Minegishi; Yoshio Shibagaki; Anna Mizutani; Koji Fujita; Tohru Tezuka; Masao Kinoshita; Masahiko Kuroda; Seisuke Hattori; Noriko Gotoh

  CANCER SCIENCE, Mar. 2013, Peer-reviewed

  
• Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c

  Kohei Takeshita; Tohru Tezuka; Yukari Isozaki; Eiki Yamashita; Mamoru Suzuki; Minsoo Kim; Yuji Yamanashi; Tadashi Yamamoto; Atsushi Nakagawa

  JOURNAL OF BIOCHEMISTRY, Nov. 2012, Peer-reviewed

  
• NMDAR2B tyrosine phosphorylation is involved in thermal nociception

  Mina Delawary; Tohru Tezuka; Yuji Kiyama; Kazumasa Yokoyama; Etsuko Wada; Keiji Wada; Toshiya Manabe; Tadashi Yamamoto; Takanobu Nakazawa

  NEUROSCIENCE LETTERS, May 2012, Peer-reviewed

  
• Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment

  Yuji Yamanashi; Tohru Tezuka; Kazumasa Yokoyama

  JOURNAL OF BIOCHEMISTRY, Apr. 2012, Peer-reviewed

  
• NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons

  Kazumasa Yokoyama; Tohru Tezuka; Masaharu Kotani; Takanobu Nakazawa; Naosuke Hoshina; Yasushi Shimoda; Shigeru Kakuta; Katsuko Sudo; Kazutada Watanabe; Yoichiro Iwakura; Tadashi Yamamoto

  EMBO JOURNAL, Nov. 2011, Peer-reviewed

  
• NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala

  Mina Delawary; Tohru Tezuka; Yuji Kiyama; Kazumasa Yokoyama; Takeshi Inoue; Satoko Hattori; Ryota Hashimoto; Hisashi Umemori; Toshiya Manabe; Tadashi Yamamoto; Takanobu Nakazawa

  MOLECULAR BRAIN, 2010, Peer-reviewed

  
• Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

  Sachiko Taniguchi; Takanobu Nakazawa; Asami Tanimura; Yuji Kiyama; Tohru Tezuka; Ayako M. Watabe; Norikazu Katayama; Kazumasa Yokoyama; Takeshi Inoue; Hiroko Izumi-Nakaseko; Shigeru Kakuta; Katsuko Sudo; Yoichiro Iwakura; Hisashi Umemori; Takafumi Inoue; Niall P. Murphy; Kouichi Hashimoto; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto

  EMBO JOURNAL, Dec. 2009, Peer-reviewed

  
• The roles of Dok family adapters in immunoreceptor signaling

  Ryuichi Mashima; Yukihiro Hishida; Tohru Tezuka; Yuji Yamanashi

  IMMUNOLOGICAL REVIEWS, Nov. 2009, Peer-reviewed

  
• Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-gamma 1

  Yutaka Harita; Hidetake Kurihara; Hidetaka Kosako; Tohru Tezuka; Takashi Sekine; Takashi Igarashi; Ikuroh Ohsawa; Shigeo Ohta; Seisuke Hattori

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2009, Peer-reviewed

  
• Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development

  June Goto; Tohru Tezuka; Takanobu Nakazawa; Hiroshi Sagara; Tadashi Yamamoto

  MOLECULAR AND CELLULAR NEUROSCIENCE, Jun. 2008, Peer-reviewed

  
• Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP

  Takanobu Nakazawa; Toshihiko Kuriu; Tohru Tezuka; Hisashi Umemori; Shigeo Okabe; Tadashi Yamamoto

  JOURNAL OF NEUROCHEMISTRY, May 2008, Peer-reviewed

  
• Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2

  Yutaka Harita; Hidetake Kurihara; Hidetaka Kosako; Tohru Tezuka; Takashi Sekine; Takashi Igarashi; Seisuke Hattori

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2008, Peer-reviewed

  
• Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury

  Makoto Tsuda; Hidetoshi Tozaki-Saitoh; Takahiro Masuda; Emika Toyomitsu; Tohru Tezuka; Tadashi Yamamoto; Kazuhide Inoue

  GLIA, Jan. 2008, Peer-reviewed

  
• Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth

  Naosuke Hoshina; Tohru Tezuka; Kazumasa Yokoyama; Hiroko Kozuka-Hata; Masaaki Oyama; Tadashi Yamamoto

  GENES TO CELLS, Nov. 2007, Peer-reviewed

  
• Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA2

  Takeshi Inukai; Kanako Uno; Kikuyo Taniguchi; Kumiko Goi; Toru Tezuka; Atsushi Nemoto; Kazuya Takahashi; Hiroki Sato; Koshi Akahane; Kinuko Hirose; Hiroko Honna; Keiko Kagami; Asako Hiraoka; Misae Tanihiro; Shinpei Nakazawa; Kanji Sugita

  BRITISH JOURNAL OF HAEMATOLOGY, Oct. 2007, Peer-reviewed

  
• Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression

  Shin-ichiro Kina; Tohru Tezuka; Shinji Kusakawa; Yasushi Kishimoto; Sho Kakizawa; Koichi Hashimoto; Miho Ohsugi; Yuji Kiyama; Reiko Horai; Katsuko Sudo; Shigeru Kakuta; Yoichiro Iwakura; Masamitsu Iino; Masanobu Kano; Toshiya Manabe; Tadashi Yamamoto

  EUROPEAN JOURNAL OF NEUROSCIENCE, Oct. 2007, Peer-reviewed

  
• Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans

  Mina Delawary; Takanobu Nakazawa; Tohru Tezuka; Mariko Sawa; Yuichi Iino; Tadaomi Takenawa; Tadashi Yamamoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2007, Peer-reviewed

  
• Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels

  Yoshiaki Kise; Kei Takenaka; Tohru Tezuka; Tadashi Yamamoto; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2006, Peer-reviewed

  
• Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene

  Seiji Kawa; Chizuru Ito; Yoshiro Toyama; Mamiko Maekawa; Tohru Tezuka; Takahisa Nakamura; Takanobu Nakazawa; Kazumasa Yokoyama; Nobuaki Yoshida; Kiyotaka Toshimori; Tadashi Yamamoto

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2006, Peer-reviewed

  
• Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases

  Kazumasa Yokoyama; Tohru Tezuka; Naosuke Hoshina; Takanobu Nakazawa; Tadashi Yamamoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2006, Peer-reviewed

  
• Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP

  Hui Liu; Takanobu Nakazawa; Tohru Tezuka; Tadashi Yamamoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2006, Peer-reviewed

  
• NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

  Takanobu Nakazawa; Shoji Komai; Ayako M. Watabe; Yuji Kiyama; Masahiro Fukaya; Fumiko Arima-Yoshida; Reiko Horai; Katsuko Sudo; Kazumi Ebine; Mina Delawary; June Goto; Hisashi Umemori; Tohru Tezuka; Yoichiro Iwakura; Masahiko Watanabe; Tadashi Yamamoto; Toshiya Manabe

  EMBO JOURNAL, Jun. 2006, Peer-reviewed

  
• Fc epsilon RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

  K Nishida; S Yamasaki; Y Ito; K Kabu; K Hattori; T Tezuka; H Nishizumi; D Kitamura; R Goitsuka; RS Geha; T Yamamoto; T Yagi; T Hirano

  JOURNAL OF CELL BIOLOGY, Jul. 2005, Peer-reviewed

  
• Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1

  S Suetsugu; T Tezuka; T Morimura; M Hattori; K Mikoshiba; T Yamamoto; T Takenawa

  BIOCHEMICAL JOURNAL, Nov. 2004, Peer-reviewed

  
• [Prevention of hepatic veno-occlusive disease by a combination of heparin and prostaglandin E1 in children undergoing hematopoietic stem cell transplantation]

  Inukai T; Sugita K; Goi K; Akahane K; Hirose K; Nemoto A; Takahashi K; Sato H; Uno K; Furuichi Y; Nakamura M; Miyamoto N; Yamakawa N; Shiraishi K; Kojika S; Tezuka T; Iijima K; Nakazawa S

  [Rinsho ketsueki] The Japanese journal of clinical hematology, Apr. 2004, Peer-reviewed

  
• [Spontaneous recovery from pancytopenia in a young female patient with paroxysmal nocturnal hemoglobinuria(PNH): changes in the GPI-anchor expression on peripheral blood cells]

  Inukai T; Sugita K; Goto M; Nakamura M; Tezuka T; Goi K; Iijima K; Ishihara T; Kagami K; Noji H; Shichishima T; Nakazawa S

  [Rinsho ketsueki] The Japanese journal of clinical hematology, Mar. 2004, Peer-reviewed

  
• Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation

  M Kim; T Tezuka; K Tanaka; T Yamamoto

  ONCOGENE, Mar. 2004, Peer-reviewed

  
• Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling.

  Kawa S; Fujimoto J; Tezuka T; Nakazawa T; Yamamoto T

  Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2004, Peer-reviewed

  
• Altered gene expression in the adult brain of fyn-deficient mice

  J Goto; T Tezuka; T Nakazawa; N Tsukamoto; T Nakamura; R Ajima; K Yokoyama; T Ohta; M Ohki; T Yamamoto

  CELLULAR AND MOLECULAR NEUROBIOLOGY, Feb. 2004, Peer-reviewed

  
• Transient decrease in the CD45RA expression on T lymphocytes in neonates with fetal distress

  N Mizobe; K Sugita; T Tezuka; M Sakamoto; Y Fukada; K Hoshi; S Nakazawa

  BIOLOGY OF THE NEONATE, 2004, Peer-reviewed

  
• [QOL in elderly patients with colorectal cancer]

  Inoue Y; Tezuka T; Shinohara T; Mitsunaga A; Ooi I; Takasaki K

  Nippon rinsho. Japanese journal of clinical medicine, Sep. 2003, Peer-reviewed

  
• p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-D-aspartate receptor signaling

  T Nakazawa; AM Watabe; T Tezuka; Y Yoshida; K Yokoyama; H Umemori; A Inoue; S Okabe; T Manabe; T Yamamoto

  MOLECULAR BIOLOGY OF THE CELL, Jul. 2003, Peer-reviewed

  
• Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.

  Yasuo Watanabe; Tao Song; Katsuyoshi Sugimoto; Mariko Horii; Nobukazu Araki; Hiroshi Tokumitsu; Tohru Tezuka; Tadashi Yamamoto; Masaaki Tokuda

  The Biochemical journal, 01 Jun. 2003, Peer-reviewed

  
• p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn

  S Taniguchi; H Liu; T Nakazawa; K Yokoyama; T Tezuka; T Yamamoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2003, Peer-reviewed

  
• Sustained activation of N-WASP through phosphorylation is essential for neurite extension

  S Suetsugu; M Hattori; H Miki; T Tezuka; T Yamamoto; K Mikoshiba; T Takenawa

  DEVELOPMENTAL CELL, Nov. 2002, Peer-reviewed

  
• [Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation].

  Nakazawa T; Tezuka T; Yamamoto T

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, Oct. 2002, Peer-reviewed

  
• Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma 2 in B cells

  T Yasuda; T Tezuka; A Maeda; T Inazu; Y Yamanashi; H Gu; T Kurosaki; T Yamamoto

  JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 2002, Peer-reviewed

  
• Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation - Its implication in an anti-apoptotic function

  D Kitagawa; S Tanemura; S Ohata; N Shimizu; J Seo; G Nishitai; T Watanabe; K Nakagawa; H Kishimoto; T Wada; T Tezuka; T Yamamoto; H Nishina; T Katada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2002, Peer-reviewed

  
• BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor

  K Yokoyama; Su, I; T Tezuka; T Yasuda; K Mikoshiba; A Tarakhovsky; T Yamamoto

  EMBO JOURNAL, Jan. 2002, Peer-reviewed

  

Misc.

• PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A

  Proc Natl. Acad. Sci USA, 1999

  
• PSD-95 Promotes Fyn-Mediated Tyrosine Phosphorylation of the N-Methyl D-Aspartate Receptor Subunit NR2A

  Proc Natl. Acad. Sci USA, 1999

  
• Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling

  Journal of Experimental Medicine, 1996

  
• Physical and Functional Association of the Cbl Protoonco Gene Product with an Src-Family Protein Tyrosire Kinase, p53/56lyn, in the B Cell Antigen Receptor-Mediated Signaling

  Journal of Experimental Medicine, 1996

  

External funds: Kakenhi

• Functional analysis of heritable risk factors for moyamoya disease and stroke

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  Tohru Tezuka

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  もやもや病;シグナル伝達;RNF213;血管閉塞性疾患;血管閉塞;細胞内シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03790/
• Mechanism and processe of stenoocclusive vascular diseases caused by RNF213 mutation in inflammatory cellular society

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  Akio Koizumi

  From 30 Jun. 2017, To 31 Mar. 2022, Project Closed

  遺伝疫学;もやもや病;感受性遺伝子;シグナル制御;RNF213;ER stress;Apoptosis;R4810K;細胞分裂;腸内細菌;RNF213-R4810K;Arterial-Stenosis;Mitotic failure;ウイルス抗体の保有状況;E3 ligase;AAA+;循環器疾患;脳卒中;R4810K変異;血管閉塞性病変

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06397/
• Signaling in NMJ formation and its synaptopathy

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Yuji Yamanashi

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  神経筋シナプス;シグナル伝達;神経科学;細胞内シグナル伝達;運動機能障害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H01532/
• Develpment of a new method to treat neuromuscular diseases

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  Tohru Tezuka

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  神経筋接合部;神経筋疾患;神経筋シナプス;神経科学;遺伝子;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14575/
• Molecular mechanisms of the formation and maintenance of NMJs

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Tohru TEZUKA

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  神経科学;神経筋接合部;シグナル伝達;神経筋疾患;神経筋シナプス;筋無力症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460357/
• 細胞内リガンドによる受容体型チロシンキナーゼの活性化機構

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  The University of Tokyo

  手塚 徹

  From 29 May 2012, To 31 Mar. 2014, Project Closed

  チロシンキナーゼ;神経筋接合部

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24121705/
• Molecular signaling in neuromuscular synaptogenesis and myasthenia

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Yuji YAMANASHI

  From 01 Apr. 2011, To 31 Mar. 2015, Project Closed

  細胞内シグナル伝達;神経筋シナプス;シグナル伝達;神経科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23249013/
• Dysfunction of planar cell polarity signaling and its relationship with ciliopathies and cancer invasion and metastasis

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kobe University

  YASUHIRO MINAMI

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  上皮管腔組織破綻;平面細胞極性シグナル;繊毛シグナル;非古典的Wntシグナル;アダプター分子;癌の浸潤・進展;上皮管腔組織形成;組織炎症;線毛シグナル;上皮管腔組織の破綻;繊毛関連症候群・炎症;癌の浸潤;エピジェネティック制御;上皮間葉転換;癌の浸潤転移;繊毛関連症候群;頂底極性シグナル;Wnt5a-Rorシグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23112007/
• Roles of Dok-7 and MuSK in neuromuscular synaptogenesis

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  Tohru TEZUKA

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  神経筋接合部;シグナル伝達;チロシンリン酸化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790266/
• Src及びCblファミリーによるチロシンリン酸化シグナルの正負の制御と脳高次機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University;The University of Tokyo

  手塚 徹

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  チロシンリン酸化;NMDA受容体;Src;Cbl;脳・神経;蛋白質リン酸化;遺伝子;ユビキチン化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18022013/
• Elucidation of roles of Cbl-family proteins in the nervous system.

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Tohru TEZUKA

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  神経系;チロシンリン酸化;神経科学;脳・神経;ユビキチン;Cbl;シグナル伝達, Nervous System;tyrosine phosphorylation;Neuroscience

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16500237/
• Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  手塚 徹

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  脳・神経;蛋白質;行動学;神経科学;シグナル伝達;チロシンリン酸化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16015233/
• Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  手塚 徹

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  チロシンキナーゼ;Cb1;記憶・学習;リン酸化;NMDA 受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15016034/
• Elucidation of NMDAR tyrosine phosphorylation by Src.

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Tohru TEZUKA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  Src;チロシンリン酸化;NMDA受容体;遺伝子改変マウス;DNAチップ解析;チロシンキナーゼ;NR2A;NR2B;記憶・学習;リン酸化;Fyn;ノックインマウス, Src;tyrosine phosphorylation;NMDA receptor;Knock-in Mice;DNA Chip Analysis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14580738/
• 神経系におけるSrc型チロシンキナーゼの新規標的基質・遺伝子群の同定及び機能解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  手塚 徹

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  Src;脳神経;チロシンリン酸化;マイクロアレイ;標的基質;転写標的遺伝子;NMDA受容体;PSD-95

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13035009/
• 蛋白質分解を介してチロシンキナーゼシグナルを抑制するCblファミリーの機能解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  The University of Tokyo

  手塚 徹

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  Cbl;チロシンキナーゼ;ユビキチン化;DT40;Src

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12780465/

External funds: others

• ゲノム編集疾患iPS細胞を用いた閉塞性血管疾患のモデル樹立と病態解明

  日本医療研究開発機構

  From 26 May 2021, To 31 Mar. 2024

  峰晴 陽平

Education

Teaching subject(s)

• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目