Basic Information

Academic Degree

• 修士（生命科学）(山口大学)
• 博士（医学）(京都大学)

Research History

• From Dec. 2022, To Present

  RIKEN, BDR, 研究員
• From Apr. 2020, To Nov. 2022

  京都大学医学部附属病院, 心臓血管外科, 助教
• From Apr. 2018, To Mar. 2020

  RIKEN, BDR

ID,URL

• J-Global ID

  202001015752762523

• Researcher number

  80884329

researchmap URL

• https://researchmap.jp/kozuemurata

Research

Research Interests

• ボルナ病ウイルス
• 再生医学
• 心臓血管外科学
• 臨床橋渡し研究
• 幹細胞生物学
• ティッシュエンジニアリング

Papers

• Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin.

  Jun Iida; Kazuki Kotani; Kozue Murata; Keisuke Hakamada; Wusiman Maihemuti; Yoshinobu Mandai; Yosuke Hiraoka; Kenji Minatoya; Hidetoshi Masumoto

  Scientific reports, 07 Feb. 2025

  
• Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells

  Wusiman Maihemuti; Kozue Murata; Mosha Abulaiti; Kenji Minatoya; Hidetoshi Masumoto

  Biochemical and Biophysical Research Communications, Nov. 2024, Peer-reviewed

  
• miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes.

  Qiaoke Yang; Kozue Murata; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto

  Scientific reports, 27 Jun. 2024, Peer-reviewed

  
• Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.

  Kozue Murata; Akiko Makino; Keizo Tomonaga; Hidetoshi Masumoto

  iScience, 19 Jan. 2024, Peer-reviewed, Lead author

  
• Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.

  Shoichi Kyo; Kozue Murata; Masahide Kawatou; Kenji Minatoya; Genshiro A Sunagawa; Hidetoshi Masumoto

  JTCVS open, Dec. 2022, Peer-reviewed

  
• Development of a bioassay system to evaluate the pulsatile function of human heart tissue using a cellular micropump on-chip and a biomimetic human iPS cell-derived heart tissue sheet technology

  Abulaiti Mosha; Kozue Murata; Yalikun Yaxiaer; Yo Tanaka; Hidetoshi Masumoto

  22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, 2018

  
• Bifidobacterium breve MCC-117 Induces Tolerance in Porcine Intestinal Epithelial Cells: Study of the Mechanisms Involved in the Immunoregulatory Effect.

  Kozue Murata; Yohsuke Tomosada; Julio Villena; Eriko Chiba; Tomoyuki Shimazu; Hisashi Aso; Noriyuki Iwabuchi; Jin-Zhong Xiao; Tadao Saito; Haruki Kitazawa

  Bioscience of microbiota, food and health, 2014

  
• Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation.

  Naoya Takanashi; Yohsuke Tomosada; Julio Villena; Kozue Murata; Takuya Takahashi; Eriko Chiba; Masanori Tohno; Tomoyuki Shimazu; Hisashi Aso; Yoshihito Suda; Shuji Ikegami; Hiroyuki Itoh; Yasushi Kawai; Tadao Saito; Susana Alvarez; Haruki Kitazawa

  BMC microbiology, 07 Mar. 2013, Peer-reviewed

  
• Bifidobacteria Upregulate Expression of Toll-Like Receptor Negative Regulators Counteracting Enterotoxigenic Escherichia coli Mediated Inflammation in Bovine Intestinal Epitheliocytes.

  Kozue Murata; Julio Villena; Yohsuke Tomosada; Risa Hara; Eriko Chiba; Tomoyuki Shimazu; Hisashi Aso; Yoshihito Suda; Noriyuki Iwabuchi; Jin-Zhong Xiao; Tadao Saito; Haruki Kitazawa

  Open Journal of Veterinary Medicine, 03 Mar. 2013, Peer-reviewed

  
• A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture.

  Wen-Jin Ho; Mako Kobayashi; Kozue Murata; Yoshihide Hashimoto; Kenji Izumi; Tsuyoshi Kimura; Hideo Kanemitsu; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto

  Scientific reports, 24 Dec. 2022, Peer-reviewed

  
• Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction.

  Yasushi Konegawa; Toshie Kuwahara; Jun-Ichiro Jo; Kozue Murata; Takahide Takeda; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto; Yasuhiko Tabata

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 04 Oct. 2022, Peer-reviewed

  
• Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells.

  Kozue Murata; Hidetoshi Masumoto

  Stem cells (Dayton, Ohio), 22 Jun. 2022, Peer-reviewed

  
• In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model.

  Shunji Kurokawa; Yoshihide Hashimoto; Seiichi Funamoto; Kozue Murata; Akitatsu Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto

  PloS one, 22 Jul. 2021, Peer-reviewed

  
• Strategies for immune regulation in iPS cell-based cardiac regenerative medicine.

  Kozue Murata; Masaya Ikegawa; Kenji Minatoya; Hidetoshi Masumoto

  Inflammation and regeneration, Dec. 2020, Lead author

  
• Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.

  Mosha Abulaiti; Yaxiaer Yalikun; Kozue Murata; Asako Sato; Mustafa M Sami; Yuko Sasaki; Yasue Fujiwara; Kenji Minatoya; Yuji Shiba; Yo Tanaka; Hidetoshi Masumoto

  Scientific reports, 05 Nov. 2020, Peer-reviewed

  
• Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder

  Tomoyuki Honda; Kozue Sofuku; Hidenori Matsunaga; Masaya Tachibana; Ikuko Mohri; Masako Taniike; Keizo Tomonaga

  Microbiology and Immunology, Jul. 2018, Peer-reviewed

  
• Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells

  Tomoyuki Honda; Kozue Sofuku; Shohei Kojima; Yusuke Yamamoto; Naohiro Ohtaki; Keizo Tomonaga

  Virology, 01 Oct. 2017, Peer-reviewed

  
• Detection of antibodies against borna disease virus proteins in an autistic child and her mother

  Tomoyuki Honda; Kozue Sofuku; Hidenori Matsunaga; Masaya Tachibana; Ikuko Mohri; Masako Taniike; Keizo Tomonaga

  Japanese Journal of Infectious Diseases, 2017, Peer-reviewed

  
• Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother

  Tomoyuki Honda; Kozue Sofuku; Hidenori Matsunaga; Masaya Tachibana; Ikuko Mohri; Masako Taniike; Keizo Tomonaga

  Japanese Journal of Infectious Diseases, 2017, Peer-reviewed

  
• Lentiavidins: Novel avidin-like proteins with low isoelectric points from shiitake mushroom (Lentinula edodes)

  Yoshimitsu Takakura; Kozue Sofuku; Masako Tsunashima; Shigeru Kuwata

  Journal of Bioscience and Bioengineering, 01 Apr. 2016, Peer-reviewed

  
• Transcription Profiling Demonstrates Epigenetic Control of Non-retroviral RNA Virus-Derived Elements in the Human Genome

  Kozue Sofuku; Nicholas F. Parrish; Tomoyuki Honda; Keizo Tomonaga

  Cell Reports, 08 Sep. 2015, Peer-reviewed, Lead author

  
• Tamavidin 2-REV: An engineered tamavidin with reversible biotin-binding capability

  Yoshimitsu Takakura; Kozue Sofuku; Masako Tsunashima

  Journal of Biotechnology, Mar. 2013, Peer-reviewed

  
• Detection of co- and posttranslational protein N-myristoylation by metabolic labeling in an insect cell-free protein synthesis system

  Nagisa Sakurai; Koko Moriya; Takashi Suzuki; Kozue Sofuku; Hiroyuki Mochiki; Osamu Nishimura; Toshihiko Utsumi

  Analytical Biochemistry, 15 Mar. 2007, Peer-reviewed

  

Presentations

• Development of a cardiotoxicity evaluation system using a Heart-on-a-Chip Microdevice with aligned fiber device

  Kozue Murata; Mosha Abulaiti; Yoshikazu Nagakaki; Kensuke Kato; Hidetoshi Masumoto

  ESC2024 London, 30 Aug. 2024

  
• 配向性ファイバーデバイスを用いた改良型ハートオンチップ型マイクロデバイスによる心毒性評価系の開発

  村田 梢; アブラティ モシャ; 長垣 良和; 加藤 謙介; 升本 英利

  第23回日本再生医療学会総会, 21 Mar. 2024

  
• ヒトiPS細胞由来マイクロ心臓組織を用いた SARS-CoV-2持続感染系の確立

  村田 梢; 牧野 晶子; 朝長 啓造; 升本 英利

  第22回 日本再生医療学会総会, 25 Mar. 2023

  
• ヒト心臓組織機能評価のためのヒトiPS細胞を用いたハートオンチップ型マイクロデバイスの開発

  村田 梢; Mosha Abulaiti; 佐藤 麻子; 佐々木 裕子; 柴 祐司; 田中 陽; 升本 英利

  第20回日本再生医療学会総会, 11 Mar. 2021

  
• DEVELOPMENT OF A BIOASSAY SYSTEM TO EVALUATE THE PULSATILE FUNCTION OF HUMAN HEART TISSUE USING A CELLULAR MICROPUMP ON-CHIP AND A BIOMIMETIC HUMAN IPS CELL-DERIVED HEART TISSUE SHEET TECHNOLOGY

  Abulaiti Mosha; Kozue Murata; Yalikun Yaxiaer; Yo Tanaka; Hidetoshi Masumoto

  The Twenty Second International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2018)

  
• Involvement of DNA damage response in Borna disease virus infection

  惣福 梢; 本田 知之; 朝長 啓造

  第 63 回日本ウイルス学会学術集会, 24 Nov. 2015

  
• Involvement of DNA damage response in Borna disease virus infection

  Kozue Sofuku; Tomoyuki Honda; Keizo Tomonaga

  XⅥ International Conference on Negative Strand Viruses, 14 Jun. 2015

  
• ヒト内在性ボルナウイルス様 N エレメントのエピジェネティック制御機構

  惣福 梢; 本田 知之; 朝長 啓造

  第 62 回日本ウイルス学会学術集会, 11 Nov. 2013

  
• ボルナ病ウイルスタンパク質とDNAダメージ修復因子の相互作用

  惣福 梢; 本田 知之; 朝長 啓造

  第61回日本ウイルス学会学術集会, 10 Nov. 2013

  
• Epigenetic regulation of the expression of an endogenous bornavirus element in the human genome

  Kozue Sofuku; Tomoyuki Honda; Keizo Tomonaga

  The 12th Awaji International Forum on Infection and Immunity, 13 Sep. 2013

  
• DNAダメージとボルナ病ウイルスとの関連性の解析

  惣福 梢; 本田 知之; 朝長 啓造

  第7回日本ボルナ病ウイルス研究会, 25 Mar. 2013

  
• 内在性ボルナウイルス様Nエレメント1の転写制御機構の解明

  惣福 梢; 本田 知之; 藤野 寛; 堀江 真行; 朝長 啓造

  第60回日本ウイルス学会学術集会, 14 Nov. 2012

  
• Tamavidin‐S:ビオチンと可逆的に結合する新規タマビジ

  惣福 梢; 綱島雅子; 高倉由光

  日本農芸化学会2010年度大会, 28 Mar. 2011

  
• アポトーシス過程で翻訳後N-ミリストイル化を生ずるタンパク質の網羅的同定法の確立

  惣福 梢; 守屋康子; 石橋直人; 八舟宏典; 鈴木崇; 内海俊彦

  第49回日本生化学会中国・四国支部例会, 17 May 2008

  
• アポトーシス過程で翻訳後N‐ミリストイル化を生ずるタンパク質の網羅的解析系の確立

  惣福 梢; 守屋康子; 石橋直人; 八舟宏典; 鈴木崇; 内海俊彦

  日本農芸化学会2007年度大会, 27 Mar. 2007

  

Industrial Property Rights

• 特許PCT/JP2020/041334, 特願PCT/JP2020/041334, ハートオンチップデバイス並びにこれを用いた心臓機能の評価方法、薬剤スクリーニング方法及び心毒性評価試験方法

  発明者; 升本英利; 田中陽; アブラティ・モシャ; 村田 梢; ヤリクン・ヤシャイラ; 佐藤麻子; 加藤謙介; 河原紀之

  
• 特願011-55827(P2011-55827A), 改変型ビオチン結合タンパク質

  惣福 梢; 高倉 由光; 綱島 雅子

  

External funds: Kakenhi

• Development of a cardiotoxicity evaluation system using a Heart-on-a-Chip Microdevice with aligned fiber device.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55030:Cardiovascular surgery-related

  Institute of Physical and Chemical Research;Kyoto University

  Kozue Murata

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  iPS細胞;心臓;オルガノイド;組織;心毒性;HMD;Organ-on-a-chip;創薬研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08861/
• Investigation of maturation mechanism of iPS cell-derived cardiac micro tissue by metabolic switch.

  Grant-in-Aid for Research Activity Start-up

  0905:Surgery of the organs maintaining homeostasis and related fields

  Kyoto University

  Kozue Murata

  From 11 Sep. 2020, To 31 Mar. 2022, Project Closed

  心臓;iPS細胞;マイクロ心臓組織;成熟化;脂肪酸;脂質代謝;心筋細胞;オルガノイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K22949/
• ヒトiPS細胞由来人工心臓組織における成熟化プロセスの理解と制御法の確立

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55030:Cardiovascular surgery-related

  Kyoto University

  長田 裕明

  From 01 Apr. 2022, To 31 Mar. 2025, Discontinued

  iPS細胞;心臓再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08934/
• ヒトiPS細胞由来マイクロ心臓組織による新規心臓再生治療法の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 55030:Cardiovascular surgery-related

  Institute of Physical and Chemical Research

  升本 英利

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  iPS細胞;心臓再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03161/
• Establishment of a protocol for maturation of human iPS cell-derived 3D cardiac microtissue using a microgravity

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55030:Cardiovascular surgery-related

  Institute of Physical and Chemical Research

  村田 梢

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  iPS細胞;心臓;成熟化;オルガノイド;微小重力

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K11982/
• 心臓血管外科領域におけるiPS細胞技術を用いた新規遺伝子治療ベクターの開発

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55030:Cardiovascular surgery-related

  Kyoto University

  池田 義

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  マイクロRNA;ドラッグデリバリーシステム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K08232/
• ヒトiPS細胞由来マイクロ心臓組織による新規心臓再生治療法の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 55030:Cardiovascular surgery-related

  Institute of Physical and Chemical Research

  升本 英利

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  iPS細胞;心臓再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24420/