Basic Information

Faculty

• Faculty of Agriculture

Email Address

• Email Address

  miyakawa.takuya.7jkyoto-u.ac.jp

Professional Memberships

• 日本農芸化学会
• 日本植物生理学会
• 植物化学調節学会
• 日本バイオイメージング学会
• 日本分子生物学会
• 日本生物物理学会
• 日本結晶学会
• 日本蛋白質科学会
• 日本食品免疫学会
• 酵素工学研究会

Academic Degree

• 23 Mar. 2004

  修士（工学）(群馬大学)
• 22 Mar. 2007

  博士（農学）(東京大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院農学生命科学研究科, 応用生命化学専攻, 博士後期課程 修了
• 群馬大学, 大学院工学研究科, 生物化学工学専攻, 博士前期課程 修了

Academic Resume (Undergraduate School/Majors)

• 群馬大学, 工学部, 生物化学工学科, 卒業

High School

• High School

  群馬県立桐生高等学校

Research History

• From Apr. 2022, To Present

  Kyoto University, Graduate School of Biostudies, 准教授
• From Apr. 2017, To Mar. 2022

  The University of Tokyo, Graduate School of Agricultural and Life Sciences, 特任准教授
• From Nov. 2010, To Mar. 2017

  The University of Tokyo, Graduate School of Agricultural and Life Sciences, 助教
• From Nov. 2007, To Oct. 2010

  The University of Tokyo, Graduate School of Agricultural and Life Sciences, 特任助教
• From Jul. 2007, To Oct. 2007

  The University of Tokyo, Graduate School of Agricultural and Life Sciences, 産学官連携研究員
• From Apr. 2007, To Jun. 2007

  The University of Tokyo, Graduate School of Agricultural and Life Sciences, 学術研究支援員

ID,URL

• ORCID ID

  0000-0001-5957-3549

• J-Global ID

  201801018117415583

• Researcher number

  50596559

researchmap URL

• https://researchmap.jp/takuya-miyakawa

Research

Research Topics, Overview of the research

• Research Topics

  Elucidation of the mechanism by which plants grow strongly while adapting to their environment and the molecular structural basis that enables control of the mechanism

• Overview of the research

  Plants produce a wide variety of bioactive substances, including phytohormones, and skillfully utilize them in their responses to the environment. Our goal is to elucidate the mechanisms of action of bioactive substances and the mechanisms of plant environmental responses and growth regulated by intracellular signaling networks and gene expression by understanding the molecular structures and dynamics that give rise to the unique functions of biological macromolecules, such as proteins and DNA. We try to approach the molecular breeding of crops with superior traits based on the new knowledge obtained from our research.

Research Interests

• シグナル伝達
• 植物ホルモン
• 構造生物学
• 分子間相互作用
• X線結晶構造解析
• クライオ電子顕微鏡
• NMR
• 有用酵素
• 蛋白質工学
• 食品
• メタボロミクス

Research Areas

• Life sciences, Applied biochemistry
• Life sciences, Structural biochemistry

Papers

• Caspase-mediated processing of TRBP regulates apoptosis during viral infection

  Keiko Shibata; Harune Moriizumi; Koji Onomoto; Yuka Kaneko; Takuya Miyakawa; Shuhei Zenno; Masaru Tanokura; Mitsutoshi Yoneyama; Tomoko Takahashi; Kumiko Ui-Tei

  Nucleic Acids Research, 19 Apr. 2024, Peer-reviewed

  
• BRZ-INSENSITIVE-LONG HYPOCOTYL8 inhibits kinase-mediated phosphorylation to regulate brassinosteroid signaling

  Zhana Chagan; Genki Nakata; Shin Suzuki; Ayumi Yamagami; Ryo Tachibana; Surina Surina; Shozo Fujioka; Minami Matsui; Tetsuo Kushiro; Takuya Miyakawa; Tadao Asami; Takeshi Nakano

  Plant Physiology, 18 Apr. 2024, Peer-reviewed

  
• BIL9 promotes both plant growth via BR signaling and drought stress resistance by binding with the transcription factor HDG11

  Surina Surina; Ayumi Yamagami; Tomoko Miyaji; Zhana Chagan; Kiwi Mi Chung; Nobutaka Mitsuda; Kaisei Nishida; Ryo Tachibana; Zhangliang Zhu; Takuya Miyakawa; Kazuo Shinozaki; Masaaki Sakuta; Tadao Asami; Takeshi Nakano

  Plant and Cell Physiology, 18 Jan. 2024, Peer-reviewed

  
• BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling

  Ryo Tachibana; Susumu Abe; Momo Marugami; Ayumi Yamagami; Rino Akema; Takao Ohashi; Kaisei Nishida; Shohei Nosaki; Takuya Miyakawa; Masaru Tanokura; Jong-Myong Kim; Motoaki Seki; Takehito Inaba; Minami Matsui; Kentaro Ifuku; Tetsuo Kushiro; Tadao Asami; Takeshi Nakano

  Nature Communications, 08 Jan. 2024, Peer-reviewed

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• Enhanced Ca2+ binding to EF-hands through phosphorylation of conserved serine residues activates MpRBOHB and chitin-triggered ROS production

  Takafumi Hashimoto; Kenji Hashimoto; Hiroki Shindo; Shoko Tsuboyama; Takuya Miyakawa; Masaru Tanokura; Kazuyuki Kuchitsu

  Physiologia Plantarum, Dec. 2023, Peer-reviewed

  
• A bHLH heterodimer regulates germ cell differentiation in land plant gametophytes

  Misaki Saito; Ryosuke Momiki; Kazuo Ebine; Yoshihiro Yoshitake; Ryuichi Nishihama; Takuya Miyakawa; Takeshi Nakano; Nobutaka Mitsuda; Takashi Araki; Takayuki Kohchi; Shohei Yamaoka

  Current Biology, 20 Nov. 2023, Peer-reviewed

  
• VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica)

  Hiroyuki Takeda; Tatsuhiko Ozawa; Hiroki Zenke; Yoh Ohnuki; Yuri Umeda; Wei Zhou; Honoka Tomoda; Akihiko Takechi; Kimiyoshi Narita; Takaaki Shimizu; Takuya Miyakawa; Yuji Ito; Tatsuya Sawasaki

  Frontiers in Bioengineering and Biotechnology, 12 Sep. 2023, Peer-reviewed

  
• Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation

  Satoshi Yamanaka; Hirotake Furihata; Yuta Yanagihara; Akihito Taya; Takato Nagasaka; Mai Usui; Koya Nagaoka; Yuki Shoya; Kohei Nishino; Shuhei Yoshida; Hidetaka Kosako; Masaru Tanokura; Takuya Miyakawa; Yuuki Imai; Norio Shibata; Tatsuya Sawasaki

  Nature Communications, 18 Aug. 2023, Peer-reviewed

  
• Identification of a new gibberellin receptor agonist, diphegaractin, by a cell-free chemical screening system

  Akira Nozawa; Ryoko Miyazaki; Yoshinao Aoki; Reina Hirose; Ryosuke Hori; Chihiro Muramatsu; Yukinori Shigematsu; Keiichirou Nemoto; Yoshinori Hasegawa; Keiko Fujita; Takuya Miyakawa; Masaru Tanokura; Shunji Suzuki; Tatsuya Sawasaki

  Communications Biology, 09 May 2023, Peer-reviewed

  
• Clock-regulated coactivators selectively control gene expression in response to different temperature stress conditions in Arabidopsis

  Satoshi Kidokoro; Izumi Konoura; Fumiyuki Soma; Takamasa Suzuki; Takuya Miyakawa; Masaru Tanokura; Kazuo Shinozaki; Kazuko Yamaguchi-Shinozaki

  Proceedings of the National Academy of Sciences of the United States of America, 18 Apr. 2023, Peer-reviewed

  
• Orally administered Lactiplantibacillus plantarum OLL2712 decreased intestinal permeability, especially in the ileum: Ingested lactic acid bacteria alleviated obesity-induced inflammation by collaborating with gut microbiota

  Yimei Wang; Tomohiro Takano; Yingyu Zhou; Rong Wang; Takayuki Toshimitsu; Toshihiro Sashihara; Masaru Tanokura; Takuya Miyakawa; Haruyo Nakajima-Adachi; Satoshi Hachimura

  Frontiers in Immunology, 23 Feb. 2023, Peer-reviewed

  
• Brassinosteroid-induced gene repression requires specific and tight promoter binding of BIL1/BZR1 via DNA shape readout

  Shohei Nosaki; Nobutaka Mitsuda; Shingo Sakamoto; Kazuki Kusubayashi; Ayumi Yamagami; Yuqun Xu; Thi Bao Chau Bui; Tohru Terada; Kenji Miura; Takeshi Nakano; Masaru Tanokura; Takuya Miyakawa

  Nature Plants, 15 Dec. 2022, Peer-reviewed, Last author, Corresponding author

  
• Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase

  Takuya Miyakawa; Jian Yang; Masato Kawasaki; Naruhiko Adachi; Ayumu Fujii; Yumiko Miyauchi; Tomonari Muramatsu; Toshio Moriya; Toshiya Senda; Masaru Tanokura

  Nature Communications, 30 Aug. 2022, Peer-reviewed, Lead author

  
• Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model

  Rong Wang; Haruyo Nakajima-Adachi; Yimei Wang; Yingyu Zhou; Wenting Gu; Erika Hiraide; Mamiko Morinaga; Ryogo Nakagawa; Shotaro Nakamura; Tomohiro Takano; Xuyang Li; Mayumi Saeki; Osamu Kaminuma; Takachika Hiroi; Kenji Uchida; Hidemasa Motoshima; Masaru Tanokura; Takuya Miyakawa; Satoshi Hachimura

  Journal of Functional Foods, Jul. 2022, Peer-reviewed, Corresponding author

  
• An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility

  Keita Negishi; Kenichi Aizawa; Takayuki Shindo; Toru Suzuki; Takayuki Sakurai; Yuichiro Saito; Takuya Miyakawa; Masaru Tanokura; Yosky Kataoka; Mitsuyo Maeda; Shota Tomida; Hiroyuki Morita; Norifumi Takeda; Issei Komuro; Kazuomi Kario; Ryozo Nagai; Yasushi Imai

  Scientific Reports, 25 May 2022, Peer-reviewed

  
• Comparison of Peanut Compounds during Roasting and the Effect of Peanut Shells

  Wanyi Chiu; Tomonari Muramatsu; Yingyu Zhou; Takuya Miyakawa; Masaru Tanokura

  ACS Food Science & Technology, 23 Mar. 2022, Peer-reviewed, Corresponding author

  
• β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway

  Yingyu Zhou; TomohiroTakano; Xuyang Li; Yimei Wang; Rong Wang; Zhangliang Zhu; Masaru Tanokura; Takuya Miyakawa; Satoshi Hachimura

  Communications Biology, 31 May 2022, Peer-reviewed, Corresponding author

  
• Physical and chemical properties of nabak (Zizyphus spina‐christi) seed kernel and sweet pepper (Capsicum annuum L.) seed oils

  Hassan Elsayed Embaby; Takuya Miyakawa; Satoshi Hachimura; Tomonari Muramatsu; Masayuki Nara; Masaru Tanokura

  Journal of the Science of Food and Agriculture, May 2022, Peer-reviewed

  
• Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation

  Yingyu Zhou; Xuyang Li; Yuki Morita; Satoshi Hachimura; Takuya Miyakawa; Sachiko Takahashi; Masaru Tanokura

  Frontiers in Oncology, 14 Sep. 2021, Peer-reviewed

  
• Gene co-expression network analysis identifies BEH3 as a stabilizer of secondary vascular development in Arabidopsis

  Tomoyuki Furuya; Masato Saito; Haruka Uchimura; Akiko Satake; Shohei Nosaki; Takuya Miyakawa; Shunji Shimadzu; Wataru Yamori; Masaru Tanokura; Hiroo Fukuda; Yuki Kondo

  The Plant Cell, 31 Aug. 2021, Peer-reviewed

  
• Different DNA-binding specificities of NLP and NIN transcription factors underlie nitrate-induced control of root nodulation.

  Hanna Nishida; Shohei Nosaki; Takamasa Suzuki; Momoyo Ito; Takuya Miyakawa; Mika Nomoto; Yasuomi Tada; Kenji Miura; Masaru Tanokura; Masayoshi Kawaguchi; Takuya Suzaki

  The Plant Cell, 13 Aug. 2021, Peer-reviewed

  
• Crystallization and melting properties studied by DSC and FTIR spectroscopy of goldenberry (Physalis peruviana) oil.

  Hassan Elsayed Embaby; Takuya Miyakawa; Satoshi Hachimura; Tomonari Muramatsu; Masayuki Nara; Masaru Tanokura

  Food Chemistry, 01 Jan. 2022, Peer-reviewed

  
• β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis

  Yingyu Zhou; Wanyi Qiu; Yimei Wang; Rong Wang; Tomohiro Takano; Xuyang Li; Zhangliang Zhu; Haruyo Nakajima-Adachi; Masaru Tanokura; Satoshi Hachimura; Takuya Miyakawa

  Biomedicines, 22 Jun. 2021, Peer-reviewed, Last author, Corresponding author

  
• Evaluation of spice and herb as phyto-derived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method

  Thi Bao Chau Bui; Shohei Nosaki; Mito Kokawa; Yuqun Xu; Yutaka Kitamura; Masaru Tanokura; Satoshi Hachimura; Takuya Miyakawa

  Bioscience Reports, 28 May 2021, Peer-reviewed, Last author, Corresponding author

  
• Antioxidant properties and inhibition of angiotensin-converting enzyme by highly active peptides from wheat gluten

  Wen-Ying Liu; Jiang-Tao Zhang; Takuya Miyakawa; Guo-Ming Li; Rui-Zeng Gu; Masaru Tanokura

  Scientific Reports, 04 Mar. 2021, Peer-reviewed

  
• Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten.

  Wen-Ying Liu; Takuya Miyakawa; Jun Lu; Yun Hua Hsieh; Ruizeng Gu; Yumiko Miyauchi; Kana Katsuno; Mu-Yi Cai; Masaru Tanokura

  Journal of Food Science and Technology, 24 Feb. 2021, Peer-reviewed

  
• Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex

  Shohei Nosaki; Tohru Terada; Akira Nakamura; Kei Hirabayashi; Yuqun Xu; Thi Bao Chau Bui; Takeshi Nakano; Masaru Tanokura; Takuya Miyakawa

  Scientific Reports, 16 Feb. 2021, Peer-reviewed, Last author, Corresponding author

  
• Intestinal regulatory T cell induction by β-elemene alleviates the formation of fat tissue-related inflammation

  Yingyu Zhou; Tomohiro Takano; Yimei Wang; Xuyang Li; Rong Wang; Yoshio Wakatsuki; Haruyo Nakajima-Adachi; Masaru Tanokura; Takuya Miyakawa; Satoshi Hachimura

  iScience, 30 Nov. 2020, Peer-reviewed, Corresponding author

  
• NIGT1 family proteins exhibit dual mode DNA recognition to regulate nutrient response-associated genes in Arabidopsis

  Yoshiaki Ueda; Shohei Nosaki; Yasuhito Sakuraba; Takuya Miyakawa; Takatoshi Kiba; Masaru Tanokura; Shuichi Yanagisawa

  PLoS Genetics, 02 Nov. 2020, Peer-reviewed

  
• Low-molecular-weight peptides with potential cardiovascular regulatory functions from Atlantic salmon skin

  Wen Ying Liu; Takuya Miyakawa; Jun Lu; Rui Zeng Gu; Yun Hua Hsieh; Yumiko Miyauchi; Kana Katsuno; Mu Yi Cai; Masaru Tanokura

  International Journal of Food Engineering, 01 Nov. 2020, Peer-reviewed

  
• Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

  Hirotake Furihata; Satoshi Yamanaka; Toshiaki Honda; Yumiko Miyauchi; Atsuko Asano; Norio Shibata; Masaru Tanokura; Tatsuya Sawasaki; Takuya Miyakawa

  Nature Communications, 14 Sep. 2020, Peer-reviewed, Last author, Corresponding author

  
• Molecular basis for substrate recognition and catalysis by a marine bacterial laminarinase

  Jian Yang; Yuqun Xu; Takuya Miyakawa; Lijuan Long; Masaru Tanokura

  Applied and Environmental Microbiology, 11 Sep. 2020, Peer-reviewed

  
• Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells

  Tomohiro Takano; Ryutaro Kotaki; Jihyun Park; Tadashi Yoshida; Yoshio Wakatsuki; Masaru Tanokura; Takuya Miyakawa; Kyoko Takahashi; Haruyo Nakajima-Adachi; Satoshi Hachimura

  Frontiers in Immunology, 11 Aug. 2020, Peer-reviewed

  
• Improved preparation of group-specific component (Gc) protein to derive macrophage activating factor

  Yuki Morita; Rong Wang; Xuyang Li; Tomonari Muramatsu; Masumi Ueda; Satoshi Hachimura; Sachiko Takahashi; Takuya Miyakawa; Masaru Tanokura

  Protein Expression and Purification, 29 Jul. 2020, Peer-reviewed, Corresponding author

  
• Functional production of human antibody by the filamentous fungus Aspergillus oryzae

  Hung Hiep Huynh; Naoki Morita; Toshihiro Sakamoto; Takuya Katayama; Takuya Miyakawa; Masaru Tanokura; Yasunori Chiba; Reiko Shinkura; Jun-Ichi Maruyama

  Fungal Biology and Biotechnology, 28 May 2020, Peer-reviewed

  
• Induction of Oral Tolerance by Pepsin-Digested Gliadin Retaining T Cell Reactivity in a Mouse Model of Wheat Allergy

  Xuyang Li; Takuya Miyakawa; Tomohiro Takano; Haruyo Nakajima-Adachi; Masaru Tanokura; Satoshi Hachimura

  International Archives of Allergy and Immunology, 16 Apr. 2020, Peer-reviewed

  
• Structural comparisons of phosphoenolpyruvate carboxykinases reveal the evolutionary trajectories of these phosphodiester energy conversion enzymes

  Yoko Chiba; Takuya Miyakawa; Yasuhiro Shimane; Ken Takai; Masaru Tanokura; Tomoyoshi Nozaki

  The Journal of Biological Chemistry, 13 Dec. 2019, Peer-reviewed

  
• NMR-based metabolic profiling and comparison of Japanese persimmon cultivars

  Shoraku Ryu; Tomonari Muramatsu; Kazuo Furihata; Feifei Wei; Masanori Koda; Takuya Miyakawa; Masaru Tanokura

  Scientific Reports, 18 Oct. 2019, Peer-reviewed

  
• GSTA4 mediates reduction of cisplatin ototoxicity in female mice

  Hyo-Jin Park; Mi-Jung Kim; Christina Rothenberger; Ashok Kumar; Edith M. Sampson; Dalian Ding; Chul Han; Karessa White; Kevin Boyd; Senthilvelan Manohar; Yong-Hwan Kim; Maria S. Ticsa; Aaron S. Gomez; Isabela Caicedo; Upal Bose; Paul J. Linser; Takuya Miyakawa; Masaru Tanokura; Thomas C. Foster; Richard Salvi; Shinichi Someya

  Nature Communications, 12 Sep. 2019, Peer-reviewed

  
• Metabolic profiling of natural and cultured Cordyceps by NMR spectroscopy

  Yi Lu; Yuee Zhi; Takuya Miyakawa; Masaru Tanokura

  Scientific Reports, 22 May 2019, Peer-reviewed

  
• Comprehensive NMR analysis of two kinds of post-fermented tea and their anti-glycation activities in vitro

  Mimin Zhang; Kenichiro Otake; Yumiko Miyauchi; Masayuki Yagi; Yoshikazu Yonei; Takuya Miyakawa; Masaru Tanokura

  Food Chemistry, 30 Mar. 2019, Peer-reviewed, Corresponding author

  
• Characterization of the Ca2+-coordination structures of L- and T-plastins in combination with their synthetic peptide analogs by FTIR spectroscopy.

  Masayuki Nara; Hisayuki Morii; Takashi Shimizu; Hiroto Shinomiya; Yuka Furuta; Kenichi Miyazono; Takuya Miyakawa; Masaru Tanokura

  Scientific Reports, 12 Mar. 2019, Peer-reviewed

  
• Structural basis of different substrate preferences of two old yellow enzymes from yeasts in the asymmetric reduction of enone compounds

  Shoichiro Horita; Michihiko Kataoka; Nahoko Kitamura; Takuya Miyakawa; Jun Ohtsuka; Yuko Maejima; Kenju Shimomura; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Bioscience, Biotechnology, and Biochemistry, Mar. 2019, Peer-reviewed

  
• Triazole Ureas Covalently Bind to Strigolactone Receptor and Antagonize Strigolactone Responses

  Hidemitsu Nakamura; Kei Hirabayashi; Takuya Miyakawa; Ko Kikuzato; Wenqian Hu; Yuqun Xu; Kai Jiang; Ikuo Takahashi; Ruri Niiyama; Naoshi Dohmae; Masaru Tanokura; Tadao Asami

  Molecular Plant, 07 Jan. 2019, Peer-reviewed

  
• Structural basis for brassinosteroid response by BIL1/BZR1

  Shohei Nosaki; Takuya Miyakawa; Yuqun Xu; Akira Nakamura; Kei Hirabayashi; Tadao Asami; Takeshi Nakano; Masaru Tanokura

  Nature Plants, 01 Oct. 2018, Peer-reviewed

  
• Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

  Xu Y; Miyakawa T; Nosaki S; Nakamura A; Lyu Y; Nakamura H; Ohto U; Ishida H; Shimizu T; Asami T; Tanokura M

  Nature Communications, 26 Sep. 2018, Peer-reviewed

  
• Rationally Designed Strigolactone Analogs as Antagonists of the D14 Receptor

  Jun Takeuchi; Kai Jiang; Kei Hirabayashi; Yusaku Imamura; Yashan Wu; Yuqun Xu; Takuya Miyakawa; Hidemitsu Nakamura; Masaru Tanokura; Tadao Asami

  Plant & Cell Physiology, 01 Aug. 2018, Peer-reviewed

  
• Quantification of terpene trilactones in Ginkgo biloba with a 1H NMR method

  Tingfu Liang; Takuya Miyakawa; Jinwei Yang; Tsutomu Ishikawa; Masaru Tanokura

  Journal of Natural Medicines, 22 May 2018, Peer-reviewed

  
• Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

  Karessa White; Mi-Jung Kim; Chul Han; Hyo-Jin Park; Dalian Ding; Kevin Boyd; Logan Walker; Paul Linser; Zaimary Meneses; Cole Slade; Jonathan Hirst; Katherine Santostefano; Naohiro Terada; Takuya Miyakawa; Masaru Tanokura; Richard Salvi; Shinichi Someya

  Scientific Reports, 22 Mar. 2018, Peer-reviewed

  
• Real-Time Monitoring of Chemical Changes in Three Kinds of Fermented Milk Products during Fermentation Using Quantitative Difference Nuclear Magnetic Resonance Spectroscopy

  Yi Lu; Hiroto Ishikawa; Yeondae Kwon; Fangyu Hu; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 14 Feb. 2018, Peer-reviewed

  
• BC-Box Motif-Mediated Neuronal Differentiation of Somatic Stem Cells.

  Hiroshi Kanno; Yuqun Xu; Takuya Miyakawa; Atsuhiko Kubo; Tetsuhiro Higashida; Nahoko Baily Kobayashi; Tetsuhiko Yoshida; Masaru Tanokura

  International Journal of Molecular Sciences, Feb. 2018, Peer-reviewed

  
• Crystal structure of a Ca2+-dependent regulator of flagellar motility reveals the open-closed structural transition

  Tomoki Shojima; Feng Hou; Yusuke Takahashi; Yoshitaka Matsumura; Masahiko Okai; Akira Nakamura; Katsutoshi Mizuno; Kazuo Inaba; Masaki Kojima; Takuya Miyakawa; Masaru Tanokura

  Scientific Reports, 31 Jan. 2018, Peer-reviewed

  
• Structural basis for controlling the enzymatic properties of polymannuronate preferred alginate lyase FlAlyA from the PL-7 family

  Hui-Min Qin; Takuya Miyakawa; Akira Inoue; Ryuji Nishiyama; Akira Nakamura; Atsuko Asano; Takao Ojima; Masaru Tanokura

  Chemical Communications, 11 Jan. 2018, Peer-reviewed

  
• Quantitation of Minor Components in Mango Juice with Band-Selective Excitation NMR Spectroscopy

  Shoraku Ryu; Masanori Koda; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 01 Nov. 2017, Peer-reviewed

  
• Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S, 3R, 4S)-4-hydroxyisoleucine with three asymmetric centers

  Xuan Shi; Takuya Miyakawa; Akira Nakamura; Feng Hou; Makoto Hibi; Jun Ogawa; Yeondae Kwon; Masaru Tanokura

  Scientific Reports, 20 Oct. 2017, Peer-reviewed

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• Laminarinase from Flavobacterium sp reveals the structural basis of thermostability and substrate specificity

  Hui-Min Qin; Takuya Miyakawa; Akira Inoue; Akira Nakamura; Ryuji Nishiyama; Takao Ojima; Masaru Tanokura

  Scientific Reports, 12 Sep. 2017, Peer-reviewed

  
• Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics

  Yuqun Xu; Lingwen Liu; Akira Nakamura; Shinichi Someya; Takuya Miyakawa; Masaru Tanokura

  Scientific Reports, 29 Aug. 2017, Peer-reviewed

  
• NMR-based metabolomics for simultaneously evaluating multiple determinants of primary beef quality in Japanese Black cattle

  Yoshinori Kodani; Takuya Miyakawa; Tomohiko Komatsu; Masaru Tanokura

  Scientific reports, 02 May 2017, Peer-reviewed

  
• Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates

  Narae Shin; Kenjiro Hanaoka; Wen Piao; Takuya Miyakawa; Tomotsumi Fujisawa; Satoshi Takeuchi; Shodai Takahashi; Torn Komatsu; Tasuku Ueno; Takuya Terai; Tahei Tahara; Masaru Tanokura; Tetsuo Nagano; Yasuteru Urao

  ACS Chemical Biology, 17 Feb. 2017, Peer-reviewed

  
• Structure and Polymannuronate Specificity of a Eukaryotic Member of Polysaccharide Lyase Family 14

  Hui-Min Qin; Takuya Miyakawa; Akira Inoue; Ryuji Nishiyama; Akira Nakamura; Atsuko Asano; Yoriko Sawano; Takao Ojima; Masaru Tanokura

  The Journal of Biological Chemistry, 10 Feb. 2017, Peer-reviewed

  
• Preparation of the Extracellular Domain of Recombinant Human Toll-like Receptor 6

  Takuya Miyakawa; Ayane Kumazawa; Yoko Fuke; Toshiro Noshita; Yumiko Miyauchi; Masahiro Okada; Masaru Tanokura

  The Protein Journal, 04 Feb. 2017, Peer-reviewed

  
• Use of NMR-Based Metabolomics To Chemically Characterize the Roasting Process of Chicory Root

  Feifei Wei; Kazuo Furihata; Mimin Zhang; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 16 Aug. 2016, Peer-reviewed

  
• Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold

  Hai Zheng; Takuya Miyakawa; Yoriko Sawano; Atsuko Asano; Akinori Okumura; Satoshi Yamagoe; Masaru Tanokura

  The Journal of Biological Chemistry, 12 Aug. 2016, Peer-reviewed

  
• Structural basis of unique ligand specificity of KAI2-like protein from parasitic weed Striga hermonthica

  Yuqun Xu; Takuya Miyakawa; Hidemitsu Nakamura; Akira Nakamura; Yusaku Imamura; Tadao Asami; Masaru Tanokura

  Scientific Reports, 10 Aug. 2016, Peer-reviewed

  
• Complex mixture analysis of organic compounds in yogurt by NMR spectroscopy

  Yi Lu; Fangyu Hu; Takuya Miyakawa; Masaru Tanokura

  Metabolites, 16 Jun. 2016, Peer-reviewed

  
• Functional heterologous expression and characterization of mannuronan C5-epimerase from the brown alga Saccharina japonica

  Akira Inoue; Aya Satoh; Mio Morishita; Yuko Tokunaga; Takuya Miyakawa; Masaru Tanokura; Takao Ojima

  Algal Research, Jun. 2016, Peer-reviewed

  
• Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein

  Kenji Nishi; Tomoko Takahashi; Masataka Suzawa; Takuya Miyakawa; Tatsuya Nagasawa; Yvelt Ming; Masaru Tanokura; Kumiko Ui-Tei

  Nucleic Acids Research, 16 Nov. 2015, Peer-reviewed

  
• Expression, purification, refolding, and enzymatic characterization of two secretory phospholipases A(2) from Neurospora crassa

  Ayumi Takayanagi; Takuya Miyakawa; Atsuko Asano; Jun Ohtsuka; Masaru Tanokura; Manabu Arioka

  Protein Expression and Purification, 11 Nov. 2015, Peer-reviewed

  
• Electron microscopic recording of myosin head power stroke in hydrated myosin filaments

  Haruo Sugi; Shigeru Chaen; Tsuyoshi Akimoto; Hiroki Minoda; Takuya Miyakawa; Yumiko Miyauchi; Masaru Tanokura; Seiryo Sugiura

  Scientific Reports, 26 Oct. 2015, Peer-reviewed

  
• NMR-based analysis of the chemical composition of Japanese persimmon aqueous extracts

  Shoraku Ryu; Kazuo Furihata; Masanori Koda; Feifei Wei; Takuya Miyakawa; Masaru Tanokura

  Magnetic Resonance in Chemistry, 19 Oct. 2015, Peer-reviewed

  
• A new target region for changing the substrate specificity of amine transaminases

  Li-Jun Guan; Jun Ohtsuka; Masahiko Okai; Takuya Miyakawa; Tomoko Mase; Yuehua Zhi; Feng Hou; Noriyuki Ito; Akira Iwasaki; Yoshihiko Yasohara; Masaru Tanokura

  Scientific Reports, 01 Jun. 2015, Peer-reviewed

  
• Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria

  Hidetomo Kobayashi; Toru Yoshida; Takuya Miyakawa; Mitsuru Tashiro; Keinosuke Okamoto; Hiroyasu Yamanaka; Masaru Tanokura; Hideaki Tsuge

  The Journal of Biological Chemistry, 24 Apr. 2015, Peer-reviewed

  
• Structure and reaction mechanism of a novel enone reductase

  Feng Hou; Takuya Miyakawa; Nahoko Kitamura; Michiki Takeuchi; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Masaru Tanokura

  The FEBS Journal, 18 Mar. 2015, Peer-reviewed

  
• Yam Tuber Storage Protein Reduces Plant Oxidants Using the Coupled Reactions as Carbonic Anhydrase and Dehydroascorbate Reductase

  You-Lin Xue; Takuya Miyakawa; Akira Nakamura; Ken-ichi Hatano; Yoriko Sawano; Masaru Tanokura

  Molecular Plant, 05 Mar. 2015, Peer-reviewed

  
• An engineered old yellow enzyme that enables efficient synthesis of (4R,6R)-Actinol in a one-pot reduction system

  Shoichiro Horita; Michihiko Kataoka; Nahoko Kitamura; Takuya Nakagawa; Takuya Miyakawa; Jun Ohtsuka; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Chembiochem, 09 Feb. 2015, Peer-reviewed

  
• Comprehensive NMR analysis of compositional changes of black garlic during thermal processing

  Tingfu Liang; Feifei Wei; Yi Lu; Yoshinori Kodani; Mitsuhiko Nakada; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 21 Jan. 2015, Peer-reviewed

  
• Structural basis for the Ca2+-enhanced thermostability and activity of PET-degrading cutinase-like enzyme from Saccharomonospora viridis AHK190

  Takuya Miyakawa; Hiroki Mizushima; Jun Ohtsuka; Masayuki Oda; Fusako Kawai; Masaru Tanokura

  Applied Microbiology and Biotechnology, 11 Dec. 2014, Peer-reviewed

  
• Analysis of Weak Affinity of beta-D-Fructofuranosyl-(2↔1)-2-acetamido-2-deoxy-alpha-D-glucopyranoside for Yeast beta-Fructofuranosidase Using NMR Spectroscopy

  Chiseko Sakuma; Kazuo Furihata; Toshiyuki Nishio; Takuya Miyakawa; Masaru Tanokura; Mitsuru Tashiro

  Journal of Carbohydrate Chemistry, 15 Oct. 2014, Peer-reviewed

  
• A secreted protein with plant-specific cysteine-rich motif functions as a mannose-binding lectin that exhibits antifungal activity

  Takuya Miyakawa; Ken-ichi Hatano; Yumiko Miyauchi; You-ichi Suwa; Yoriko Sawano; Masaru Tanokura

  Plant Physiology, 19 Aug. 2014, Peer-reviewed

  
• Structural optimization of SadA, an Fe(II)- and alpha-ketoglutarate-dependent dioxygenase targeting biocatalytic synthesis of N-succinyl-L-threo-3, 4-dimethoxyphenylserine

  Hui-Min Qin; Takuya Miyakawa; Akira Nakamura; Makoto Hibi; Jun Ogawa; Masaru Tanokura

  Biochemical and Biophysical Research Communications, 08 Aug. 2014, Peer-reviewed

  
• A novel Ca2+-activated, thermostabilized polyesterase capable of hydrolyzing polyethylene terephthalate from Saccharomonospora viridis AHK190

  Fusako Kawai; Masayuki Oda; Tomonari Tamashiro; Tomonori Waku; Naoki Tanaka; Masaki Yamamoto; Hiroki Mizushima; Takuya Miyakawa; Masaru Tanokura

  Applied Microbiology and Biotechnology, 15 Jun. 2014, Peer-reviewed

  
• Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid, and RALDH expression compared to young mice

  Jihyun Park; Takuya Miyakawa; Aya Shiokawa; Haruyo Nakajima-Adachi; Masaru Tanokura; Satoshi Hachimura

  Bioscience, Biotechnology, and Biochemistry, 13 Jun. 2014, Peer-reviewed

  
• Definite differences between in vitro actin-myosin sliding and muscle contraction as revealed using antibodies to myosin head

  Haruo Sugi; Shigeru Chaen; Takakazu Kobayashi; Takahiro Abe; Kazushige Kimura; Yasutake Saeki; Yoshiki Ohnuki; Takuya Miyakawa; Masaru Tanokura; Seiryo Sugiura

  PLoS One, 11 Jun. 2014, Peer-reviewed

  
• A pilot study of NMR-based sensory prediction of roasted coffee bean extracts

  Feifei Wei; Kazuo Furihata; Takuya Miyakawa; Masaru Tanokura

  Food Chemistry, 01 Jun. 2014, Peer-reviewed

  
• L-allo-Threonine aldolase with an H128Y/S292R mutation from Aeromonas jandaei DK-39 reveals the structural basis of changes in substrate stereoselectivity

  Hui-Min Qin; Fabiana Lica Imai; Takuya Miyakawa; Michihiko Kataoka; Nahoko Kitamura; Nobuyuki Urano; Koji Mori; Hiroshi Kawabata; Masahiko Okai; Jun Ohtsuka; Feng Hou; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Acta Crystallographica. Section D, Biological Crystallography, 30 May 2014, Peer-reviewed

  
• Structural basis for high substrate-binding affinity and enantioselectivity of 3-quinuclidinone reductase AtQR

  Feng Hou; Takuya Miyakawa; Michihiko Kataoka; Daijiro Takeshita; Shoko Kumashiro; Atsuko Uzura; Nobuyuki Urano; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Biochemical and Biophysical Research Communications, 18 Apr. 2014, Peer-reviewed

  
• Broadband WET: a novel technique for quantitative characterization of minor components in foods

  Kazuo Furihata; Jing Zhang; Masanori Koda; Takuya Miyakawa; Masaru Tanokura

  Magnetic Resonance in Chemistry, 10 Apr. 2014, Peer-reviewed

  
• Splenic stromal cells from aged mice produce higher levels of IL-6 compared to young mice

  Jihyun Park; Takuya Miyakawa; Aya Shiokawa; Haruyo Nakajima-Adachi; Masaru Tanokura; Satoshi Hachimura

  Mediators of Inflammation, 04 Mar. 2014, Peer-reviewed

  
• Structural basis of stereospecific reduction by quinuclidinone reductase

  Daijiro Takeshita; Michihiko Kataoka; Takuya Miyakawa; Ken-ichi Miyazono; Shoko Kumashiro; Takahiro Nagai; Nobuyuki Urano; Atsuko Uzura; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  AMB Express, 07 Feb. 2014, Peer-reviewed

  
• A sequence-specific DNA glycosylase mediates restriction-modification in Pyrococcus abyssi

  Ken-ichi Miyazono; Yoshikazu Furuta; Miki Watanabe-Matsui; Takuya Miyakawa; Tomoko Ito; Ichizo Kobayashi; Masaru Tanokura

  Nature Communications, 24 Jan. 2014, Peer-reviewed

  
• Calcium-dependent structural changes in human reticulocalbin-1

  Nanao Suzuki; Syoko Ban; Eriko Itoh; Sisi Chen; Fabiana L. Imai; Yoriko Sawano; Takuya Miyakawa; Masaru Tanokura; Naoto Yonezawa

  The Journal of Biological Chemistry, 21 Jan. 2014, Peer-reviewed

  
• Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures

  Dalian Ding; Weidong Qi; Dongzhen Yu; Haiyan Jiang; Chul Han; Mi-Jung Kim; Kana Katsuno; Yun Hua Hsieh; Takuya Miyakawa; Richard Salvi; Masaru Tanokura; Shinichi Someya

  PLoS One, 06 Nov. 2013, Peer-reviewed

  
• Molecular mechanism of strigolactone perception by DWARF14

  Nakamura, Hidemitsu; Xue, You-Lin; Miyakawa, Takuya; Hou, Feng; Qin, Hui-Min; Fukui, Kosuke; Shi, Xuan; Ito, Emi; Ito, Shinsaku; Park, Seung-Hyun; Miyauchi, Yumiko; Asano, Atsuko; Totsuka, Naoya; Ueda, Takashi; Tanokura, Masaru; Asami, Tadao

  Nature Communications, 17 Oct. 2013, Peer-reviewed

  
• Evaluation of nonionic adsorbent resins for removal of inhibitory compounds from corncob hydrolysate for ethanol fermentation

  Ken-ichi Hatano; Naokazu Aoyagi; Takuya Miyakawa; Masaru Tanokura; Kenji Kubota

  Bioresource Technology, 15 Sep. 2013, Peer-reviewed

  
• Crystal structure of conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 complexed with NADPH

  Hui-Min Qin; Akihiro Yamamura; Takuya Miyakawa; Michihiko Kataoka; Shintaro Maruoka; Jun Ohtsuka; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Proteins, 23 Aug. 2013, Peer-reviewed

  
• A thermoacidophile-specific protein family, DUF3211, functions as a fatty acid carrier with novel binding mode

  Takuya Miyakawa; Yoriko Sawano; Ken-ichi Miyazono; Yumiko Miyauchi; Ken-ichi Hatano; Masaru Tanokura

  Journal of Bacteriology, 08 Jul. 2013, Peer-reviewed

  
• Structure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding

  Hui-Min Qin; Akihiro Yamamura; Takuya Miyakawa; Michihiko Kataoka; Takahiro Nagai; Nahoko Kitamura; Nobuyuki Urano; Shintaro Maruoka; Jun Ohtsuka; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Applied Microbiology and Biotechnology, 05 Jul. 2013, Peer-reviewed

  
• The flavoenzyme azobenzene reductase AzoR from Escherichia coli binds roseoflavin mononucleotide (RoFMN) with high affinity and is less active in its RoFMN form

  Simone Langer; Shinobu Nakanishi; Tilo Mathes; Tanja Knaus; Alexandra Binter; Peter Macheroux; Tomoko Mase; Takuya Miyakawa; Masaru Tanokura; Matthias Mack

  Biochemistry, 25 Jun. 2013, Peer-reviewed

  
• Crystal structure of a novel N-substituted L-amino acid dioxygenase from Burkholderia ambifaria AMMD

  Hui-Min Qin; Takuya Miyakawa; Min Ze Jia; Akira Nakamura; Jun Ohtsuka; You-Lin Xue; Takashi Kawashima; Takuya Kasahara; Makoto Hibi; Jun Ogawa; Masaru Tanokura

  PLoS One, 28 May 2013, Peer-reviewed

  
• Distinguishable in vitro binding mode of monomeric TRBP and dimeric PACT with siRNA

  Tomoko Takahashi; Takuya Miyakawa; Shuhei Zenno; Kenji Nishi; Masaru Tanokura; Kumiko Ui-Tei

  PLoS One, 02 May 2013, Peer-reviewed

  
• Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein

  Akinori Okumura; Takehiro Suzuki; Hideyuki Miyatake; Tomoya Okabe; Yuki Hashimoto; Takuya Miyakawa; Hai Zheng; Hiroyuki Unoki-Kubota; Hideaki Ohno; Naoshi Dohmae; Yasushi Kaburagi; Yoshitsugu Miyazaki; Masaru Tanokura; Satoshi Yamagoe

  FEBS Letters, 01 Mar. 2013, Peer-reviewed

  
• Crystallization and preliminary X-ray analysis of human leukocyte cell-derived chemotaxin 2 (LECT2)

  Hai Zheng; Takuya Miyakawa; Yoriko Sawano; Satoshi Yamagoe; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Mar. 2013, Peer-reviewed

  
• Expression, high-pressure refolding and purification of human leukocyte cell-derived chemotaxin 2 (LECT2)

  Hai Zheng; Takuya Miyakawa; Yoriko Sawano; Satoshi Yamagoe; Masaru Tanokura

  Protein Expression and Purification, 19 Jan. 2013, Peer-reviewed

  
• Different Ca2+-sensitivities between the EF-hands of T- and L-plastins

  Takuya Miyakawa; Hiroto Shinomiya; Fumiaki Yumoto; Yumiko Miyauchi; Hiroyuki Tanaka; Takao Ojima; Yusuke S. Kato; Masaru Tanokura

  Biochemical and Biophysical Research Communications, 14 Dec. 2012, Peer-reviewed

  
• Structure of the Ca(2+)-saturated C-terminal domain of scallop troponin C in complex with a troponin I fragment

  Yusuke S Kato; Fumiaki Yumoto; Hiroyuki Tanaka; Takuya Miyakawa; Yumiko Miyauchi; Daijiro Takeshita; Yoriko Sawano; Takao Ojima; Iwao Ohtsuki; Masaru Tanokura

  Biological Chemistry, 04 Dec. 2012, Peer-reviewed

  
• (13)C NMR-based metabolomics for the classification of green coffee beans according to variety and origin

  Feifei Wei; Kazuo Furihata; Masanori Koda; Fangyu Hu; Rieko Kato; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 10 Oct. 2012, Peer-reviewed

  
• Expression, purification, crystallization and X-ray analysis of 3-quinuclidinone reductase from Agrobacterium tumefaciens

  Feng Hou; Takuya Miyakawa; Daijiro Takeshita; Michihiko Kataoka; Atsuko Uzura; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Oct. 2012, Peer-reviewed

  
• Expression, purification, crystallization and preliminary X-ray analysis of a novel N-substituted branched-chain l-amino-acid dioxygenase from Burkholderia ambifaria AMMD

  Hui-Min Qin; Takuya Miyakawa; Akira Nakamura; You-Lin Xue; Takashi Kawashima; Takuya Kasahara; Makoto Hibi; Jun Ogawa; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Sep. 2012, Peer-reviewed

  
• Expression, purification, crystallization and preliminary X-ray analysis of 4-hydroxy-3-methyl-2-keto-pentanoate aldolase (asHPAL) from Arthrobacter simplex strain AKU 626

  Linjun Guo; Masahiko Okai; Tomoko Mase; Fabiana Lica Imai; Takuya Miyakawa; Koji Nagata; Hiroyuki Yamanaka; Hidemi Fujii; Makoto Hibi; Jun Ogawa; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Aug. 2012, Peer-reviewed

  
• High pressure refolding, purification, and crystallization of flavin reductase from Sulfolobus tokodaii strain 7

  Masahiko Okai; Jun Ohtsuka; Atsuko Asano; Linjun Guo; Takuya Miyakawa; Ken-ichi Miyazono; Akira Nakamura; Akitoshi Okada; Hai Zheng; Kenzo Kimura; Koji Nagata; Masaru Tanokura

  Protein Expression and Purification, 19 Jun. 2012, Peer-reviewed

  
• NMR-based metabolic profiling of rice wines by F(2)-selective total correlation spectra

  Masanori Koda; Kazuo Furihata; Feifei Wei; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 16 May 2012, Peer-reviewed

  
• Expression, purification, crystallization and preliminary X-ray analysis of carbonyl reductase S1 from Candida magnoliae

  Yoichi Suwa; Jun Ohtsuka; Takuya Miyakawa; Fabiana Lica Imai; Masahiko Okai; Yoriko Sawano; Yoshihiko Yasohara; Michihiko Kataoka; Sakayu Shimizu; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 May 2012, Peer-reviewed

  
• Metabolic discrimination of mango juice from various cultivars by band-selective NMR spectroscopy

  Masanori Koda; Kazuo Furihata; Feifei Wei; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 08 Feb. 2012, Peer-reviewed

  
• Roasting process of coffee beans as studied by nuclear magnetic resonance: time course of changes in composition

  Feifei Wei; Kazuo Furihata; Masanori Koda; Fangyu Hu; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 01 Feb. 2012, Peer-reviewed

  
• Crystallization and preliminary X-ray crystallographic analysis of dioscorin from Dioscorea japonica

  You-Lin Xue; Takuya Miyakawa; Yoriko Sawano; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Feb. 2012, Peer-reviewed

  
• Cloning of genes and enzymatic characterizations of novel dioscorin isoforms from Dioscorea japonica

  You-Lin Xue; Takuya Miyakawa; Yoriko Sawano; Masaru Tanokura

  Plant Science, 04 Nov. 2011, Peer-reviewed

  
• F2-selective two-dimensional NMR spectroscopy for the analysis of minor components in foods

  Masanori Koda; Kazuo Furihata; Feifei Wei; Takuya Miyakawa; Masaru Tanokura

  Magnetic Resonance in Chemistry, 17 Oct. 2011, Peer-reviewed

  
• Two-dimensional 1H-13C nuclear magnetic resonance (NMR)-based comprehensive analysis of roasted coffee bean extract

  Feifei Wei; Kazuo Furihata; Fangyu Hu; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 14 Sep. 2011, Peer-reviewed

  
• Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae

  Shoichiro Horita; Nobuto Matsushita; Tomoyuki Kawachi; Reed Ayabe; Masahiro Miyashita; Takuya Miyakawa; Yoshiaki Nakagawa; Koji Nagata; Hisashi Miyagawa; Masaru Tanokura

  Biochemical and Biophysical Research Communications, 12 Aug. 2011, Peer-reviewed

  
• Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion

  You-Lin Xue; Tomoyuki Ahiko; Takuya Miyakawa; Hisako Amino; Fangyu Hu; Kazuo Furihata; Kiyoshi Kita; Takuji Shirasawa; Yoriko Sawano; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 08 Jun. 2011, Peer-reviewed

  
• Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki

  You-Lin Xue; Takuya Miyakawa; Yasuna Hayashi; Kyoko Okamoto; Fangyu Hu; Nobuhito Mitani; Kazuo Furihata; Yoriko Sawano; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 08 Jun. 2011, Peer-reviewed

  
• Electron microscopic evidence for the myosin head lever arm mechanism in hydrated myosin filaments using the gas environmental chamber

  Hiroki Minoda; Tatsuhiro Okabe; Yuhri Inayoshi; Takuya Miyakawa; Yumiko Miyauchi; Masaru Tanokura; Eisaku Katayama; Takeyuki Wakabayashi; Tsuyoshi Akimoto; Haruo Sugi

  Biochemical and Biophysical Research Communications, 25 Feb. 2011, Peer-reviewed

  
• One-week antihypertensive effect of Ile-Gln-Pro in spontaneously hypertensive rats

  Jun Lu; Yoriko Sawano; Takuya Miyakawa; You-Lin Xue; Mu-Yi Cai; Yukari Egashira; Di-Feng Ren; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 26 Jan. 2011, Peer-reviewed

  
• Isolation, cDNA cloning, and structure-based functional characterization of oryctin, a hemolymph protein from the coconut rhinoceros beetle, Oryctes rhinoceros, as a novel serine protease inhibitor

  Shoichiro Horita; Jun Ishibashi; Koji Nagata; Takuya Miyakawa; Minoru Yamakawa; Masaru Tanokura

  The Journal of Biological Chemistry, 24 Sep. 2010, Peer-reviewed

  
• Complex mixture analysis of organic compounds in green coffee bean extract by two-dimensional NMR spectroscopy

  Feifei Wei; Kazuo Furihata; Fangyu Hu; Takuya Miyakawa; Masaru Tanokura

  Magnetic Resonance in Chemistry, 05 Sep. 2010, Peer-reviewed

  
• Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice

  Asimina Hiona; Alberto Sanz; Gregory C. Kujoth; Reinald Pamplona; Arnold Y. Seo; Tim Hofer; Shinichi Someya; Takuya Miyakawa; Chie Nakayama; Alejandro K. Samhan-Arias; Stephane Servais; Jamie L. Barger; Manuel Portero-Otin; Masaru Tanokura; Tomas A. Prolla; Christiaan Leeuwenburgh

  PLoS One, 07 Jul. 2010, Peer-reviewed

  
• Isolation of an antihypertensive peptide from alcalase digest of Spirulina platensis

  Jun Lu; Di-Feng Ren; You-Lin Xue; Yoriko Sawano; Takuya Miyakawa; Masaru Tanokura

  Journal of Agricultural and Food Chemistry, 23 Jun. 2010, Peer-reviewed

  
• Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1

  E. Fujita; H. Dai; Y. Tanabe; Y. Zhiling; T. Yamagata; T. Miyakawa; M. Tanokura; M. Y. Momoi; T. Momoi

  Cell Death & Disease, 03 Jun. 2010, Peer-reviewed

  
• Structural basis of abscisic acid signalling

  Ken-ichi Miyazono; Takuya Miyakawa; Yoriko Sawano; Keiko Kubota; Hee-Jin Kang; Atsuko Asano; Yumiko Miyauchi; Mihoko Takahashi; Yuehua Zhi; Yasunari Fujita; Takuya Yoshida; Ken-Suke Kodaira; Kazuko Yamaguchi-Shinozaki; Masaru Tanokura

  Nature, 03 Dec. 2009, Peer-reviewed

  
• Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain

  Takeshi Katayama; Masaru Watanabe; Hideyuki Tanaka; Mizuki Hino; Takuya Miyakawa; Takashi Ohki; Li-Hong Ye; Ce Xie; Shinji Yoshiyama; Akio Nakamura; Ryoki Ishikawa; Masaru Tanokura; Kazuhiro Oiwa; Kazuhiro Kohama

  American Journal of Physiology - Heart and Circulatory Physiology, 20 Nov. 2009, Peer-reviewed

  
• Expression, purification, crystallization and preliminary X-ray analysis of conjugated polyketone reductase C2 (CPR-C2) from Candida parapsilosis IFO 0708

  Akihiro Yamamura; Shintaro Maruoka; Jun Ohtsuka; Takuya Miyakawa; Koji Nagata; Michihiko Kataoka; Nahoko Kitamura; Sakayu Shimizu; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Nov. 2009, Peer-reviewed

  
• Crystal structure of ginkbilobin-2 with homology to the extracellular domain of plant cysteine-rich receptor-like kinases

  Takuya Miyakawa; Ken-ichi Miyazono; Yoriko Sawano; Ken-ichi Hatano; Masaru Tanokura

  Proteins, 02 Jun. 2009, Peer-reviewed

  
• Crystallization and preliminary X-ray analysis of the NADPH-dependent 3-quinuclidinone reductase from Rhodotorula rubra

  Daijiro Takeshita; Michihiko Kataoka; Takuya Miyakawa; Ken-ichi Miyazono; Atsuko Uzura; Koji Nagata; Sakayu Shimizu; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Jun. 2009, Peer-reviewed

  
• Absolute side-chain structure at position 13 is required for the inhibitory activity of bromein

  Yoriko Sawano; Ken-ichi Hatano; Takuya Miyakawa; Masaru Tanokura

  The Journal of Biological Chemistry, 26 Dec. 2008, Peer-reviewed

  
• Direct demonstration of the cross-bridge stroke in muscle thick filaments in recovery aqueous solution by using the hydration chamber

  Haruo Sugi; Hiroki Minoda; Yuhri Lnayoshi; Fumiaki Yumoto; Takuya Miyakawa; Yumiko Miyaluchi; Masaru Tanokura; Tsuyoshi Akimoto; Takakazu Kobayashi; Shigeru Chaen; Seiryo Sugiura

  Proceedings of the National Academy of Sciences of the United States of America, 05 Nov. 2008, Peer-reviewed

  
• Spectroscopic and ITC study of the conformational change upon Ca2+-binding in TnC Globe and TO peptide complex from Akazara scallop striated muscle

  Fumiaki Yumoto; Hiroyuki Tanaka; Koji Nagata; Yumiko Miyauchi; Takuya Miyakawa; Takao Ojima; Masaru Tanokura

  Biochemical and Biophysical Research Communications, 25 Apr. 2008, Peer-reviewed

  
• Proteinase inhibitor from ginkgo seeds is a member of the plant nonspecific lipid transfer protein gene family

  Yoriko Sawano; Ken-ichi Hatano; Takuya Miyakawa; Hideki Komagata; Yumiko Miyauchi; Hiroshi Yamazaki; Masaru Tanokura

  Plant Physiology, 27 Feb. 2008, Peer-reviewed

  
• Separation and characterization of the colored material from sugarcane molasses

  Ken-ichi Hatano; Satoshi Kikuchi; Takuya Miyakawa; Masaru Tanokura; Kenji Kubota

  Chemosphere, 11 Feb. 2008, Peer-reviewed

  
• Crystallization and preliminary X-ray analysis of ginkbilobin-2 from Ginkgo biloba seeds: a novel antifungal protein with homology to the extracellular domain of plant cysteine-rich receptor-like kinases

  Takuya Miyakawa; Yoriko Sawano; Ken-ichi Miyazono; Ken-ichi Hatano; Masaru Tanokura

  Acta Crystallographica. Section D, Biological Crystallography, 01 Sep. 2007, Peer-reviewed

  
• Purification, characterization, and molecular gene cloning of an antifungal protein from Ginkgo biloba seeds

  Yoriko Sawano; Takuya Miyakawa; Hiroshi Yamazaki; Masaru Tanokura; Ken-ichi Hatano

  Biological Chemistry, 01 Mar. 2007, Peer-reviewed

  
• Structure of FBP11WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains

  Yusuke Kato; Takuya Miyakawa; Jun-ichi Kurita; Masaru Tanokura

  The Journal of Biological Chemistry, 29 Dec. 2006, Peer-reviewed

  
• Crystal structure of the YjgF/YER057c/UK114 family protein from the hyperthermophilic Archaeon Sulfolobus tokodaii strain 7

  Takuya Miyakawa; Woo Cheol Lee; Ken-ichi Hatano; Yusuke Kato; Yoriko Sawano; Ken-ichi Miyazono; Koji Nagata; Masaru Tanokura

  Proteins, 01 Feb. 2006, Peer-reviewed

  
• Characterization of the acidic and basic limbs of a bell-shaped pH profile in the inhibitory activity of bromelain inhibitor VI

  Ken-ichi Hatano; Yoriko Sawano; Takuya Miyakawa; Masaru Tanokura

  Biopolymers, 28 Nov. 2005, Peer-reviewed

  
• Crystallization and preliminary X-ray analysis of the YjgF/YER057c/UK114-family protein ST0811 from Sulfolobus tokodaii strain 7

  Takuya Miyakawa; Ken Ichi Hatano; Woo Cheol Lee; Yusuke Kato; Yoriko Sawano; Fumiaki Yumoto; Koji Nagata; Masaru Tanokura

  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 01 Sep. 2005, Peer-reviewed

  

Misc.

• 非典型的な二量体構造をとるbHLH様転写因子BIL1/BZR1によるブラシノステロイド応答性遺伝子の発現調節機構

  宮川拓也; 野﨑翔平; 中野雄司

  植物の生長調節, 31 May 2024

  
• 植物特異的転写因子のDNA形状読み取りによる遺伝子発現制御

  宮川拓也; 中野雄司

  化学と生物, 01 Apr. 2024

  
• ブラシノステロイド応答遺伝子を発現制御する転写因子のDNA形状認識機構

  宮川拓也; 中野雄司

  バイオサイエンスとインダストリー, 10 Jul. 2023

  
• MEATabolomics: Muscle and Meat Metabolomics in Domestic Animals

  Susumu Muroya; Shuji Ueda; Tomohiko Komatsu; Takuya Miyakawa; Per Ertbjerg

  Metabolites, 11 May 2020, Peer-reviewed

  
• ３つの不斉中心を同時に制御する酵素触媒の開発

  日比慎; 宮川拓也; 田之倉優; 小川順

  バイオサイエンスとインダストリー, 09 Nov. 2019

  
• Molecular basis of strigolactone perception in root-parasitic plants: aiming to control its germination with strigolactone agonists/antagonists

  Takuya Miyakawa; Yuqun Xu; Masaru Tanokura

  Cellular and Molecular Life Sciences, 05 Oct. 2019, Peer-reviewed

  
• 老化の分子基盤. 食と老化

  宮川拓也

  医学のあゆみ, 25 Aug. 2018

  
• Overview of the mechanism of cytoskeletal motors based on structure

  Yusuke Kato; Takuya Miyakawa; Masaru Tanokura

  Biophysical Reviews, 10 Apr. 2018, Peer-reviewed

  
• カロリー制限 VS 断食．カロリー制限

  宮川拓也; 染谷慎一; 白川太郎; 田之倉優

  アンチ・エイジング医学, 2018

  
• Structural basis for the regulation of phytohormone receptors

  Takuya Miyakawa; Masaru Tanokura

  Bioscience, Biotechnology, and Biochemistry, 18 Apr. 2017

  
• 運動と加齢性難聴

  染谷慎一; 宮川拓也; 田之倉優

  化学と教育, 2017

  
• シンポジウム記録 水圏生物タンパク質科学の新展開 Ⅱ l. 水圏生物タンパク質の構造生物学

  宮川拓也; 田之倉優

  水産学会誌, 2017

  
• 和牛肉の肉質・熟成評価のためのNMRメタボロミクス

  宮川拓也; 田之倉優

  平成28年度低温センター年報, 2017

  
• NMRメタボリックプロファイリング－食品の迅速評価への応用と期待

  宮川拓也; 田之倉優

  化学, 01 Sep. 2016

  
• Enzymes useful for chiral compound synthesis: structural biology, directed evolution, and protein engineering for industrial use

  Michihiko Kataoka; Takuya Miyakawa; Sakayu Shimizu; Masaru Tanokura

  Applied Microbiology and Biotechnology, 17 May 2016

  
• 用語解説 NMRメタボリックプロファイリング

  宮川拓也; 田之倉優

  畜産技術, 2016

  
• Structural analysis of enzymes used for bioindustry and bioremediation

  Masaru Tanokura; Takuya Miyakawa; Lijun Guan; Feng Hou

  Bioscience, Biotechnology, and Biochemistry, 15 Jun. 2015

  
• ミトコンドリアと老化 (第5土曜特集 老化と老年疾患 : 研究・臨床の最前線) -- (老化の分子機構)

  宮川拓也; 染谷慎一; 田之倉優

  医学のあゆみ, 30 May 2015

  
• ストリゴラクトン受容体の構造とシグナル伝達のしくみ

  中村 英光; 宮川 拓也; 田之倉 優; 浅見 忠男

  化学と生物, 15 Feb. 2015

  
• アブシシン酸受容体の構造に基づく植物の乾燥ストレス応答制御の理解

  宮川 拓也; 田之倉優

  生化学, 25 Oct. 2014

  
• NMRプロファイリングによる食品の加工・品質・機能性の総合評価

  小谷 良徳; 宮川 拓也; 田之倉優

  Bioindustry, 12 Aug. 2014

  
• NMRによるコーヒー豆抽出物の非破壊分析

  魏 菲菲; 宮川 拓也; 田之倉優

  平成24年度低温センター年報, 2014

  
• Structure and function of abscisic acid receptors

  Takuya Miyakawa; Yasunari Fujita; Kazuko Yamaguchi-Shinozaki; Masaru Tanokura

  Trends in Plant Science, 22 Dec. 2012, Peer-reviewed

  
• 高分解能構造決定のための微小重力環境を利用したタンパク質結晶化

  宮川拓也; 田之倉優

  日本結晶成長学会誌, 2012

  
• Regulatory mechanism of abscisic acid signaling

  Takuya Miyakawa; Masaru Tanokura

  Biophysics, 23 Nov. 2011

  
• 植物が乾燥ストレスに応答する仕組み：アブシジン酸シグナル伝達の制御機構

  宮川拓也; 田之倉優

  日本結晶学会誌, 30 Jun. 2011

  
• アブシジン酸受容体研究の進展

  田之倉優; 宮川拓也

  生物物理, 2011

  
• Molecular basis of the core regulatory network in ABA responses: sensing, signaling and transport

  Taishi Umezawa; Kazuo Nakashima; Takuya Miyakawa; Takashi Kuromori; Masaru Tanokura; Kazuo Shinozaki; Kazuko Yamaguchi-Shinozaki

  Plant & Cell Physiology, 26 Oct. 2010

  
• アブシシン酸シグナル伝達の構造基盤

  宮川拓也

  バイオイメージング, 2010

  
• 近年の酵素・タンパク質結晶構造解析の進歩と展開

  田之倉優; 永田宏次; 宮園健一; 宮川拓也; 岡井公彦

  日本結晶学会誌, 2010

  
• 放線菌における有用物質生産制御因子の構造・機能解析

  宮川拓也; 大西康夫; 田之倉優; 堀之内末治

  蛋白質核酸酵素, 10 Sep. 2009

  

Books and Other Publications

• 生物の寿命延長 ～老化・長寿命の基盤研究最前線～

  宮川拓也; 田之倉優, Contributor, pp.85-93

  エヌ・ティー・エス, 22 Mar. 2022

  
• e-水産学シリーズ1 水圏生物タンパク質科学の新展開

  宮川拓也; 田之倉優, Contributor, pp.184-202, 269-276

  恒星社厚生閣, 30 Oct. 2020

  
• Nuts & Seeds in Health and Disease Prevention (2nd edition)

  Ken-ichi Hatano; Takuya Miyakawa; Masaru Tanokura, Contributor, pp.241-254

  Academic Press, 24 Apr. 2020

  
• 膜タンパク質工学ハンドブック

  宮川拓也; 田之倉優, Contributor, pp.465-475

  エヌ・ティー・エス, 24 Apr. 2020

  
• Green Coffee Bean Extract in Human Health

  Anh Hong Phan; Takuya Miyakawa; Masaru Tanokura, Contributor, pp.217-231

  CRC Press, 05 Aug. 2016, Not refereed

  
• Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods

  Takuya Miyakawa; Tingfu Liang; Masaru Tanokura, Contributor, pp.379-387

  Wiley Blacwell, 14 Aug. 2015, Not refereed

  
• ドラッグデザイン 構造とリガンドに基づくアプローチ

  田之倉優; 宮川拓也, Joint translation, pp.93-104

  東京化学同人, 01 Apr. 2014, Not refereed

  
• 21世紀のバイオサイエンス 実験農芸化学

  宮川拓也, Contributor, pp.135–139, 150–151

  朝倉書店, 10 Apr. 2013, Not refereed

  
• Magnetic Resonance in Food Science: Food for Thought

  Feifei Wei; Kazuo Furihata; Takuya Miyakawa; Masanori Koda; Fangyu Hu; Masaru Tanokura, Contributor, pp.183-192

  RSC Publishing, 2013, Not refereed

  
• Nuts & Seeds in Health and Disease Prevention

  Ken-ichi Hatano; Takuya Miyakawa; Yoriko Sawano; Masaru Tanokura, Contributor, pp.527-534

  Academic Press, 2011, Not refereed

  
• 入門 構造生物学－放射光X線と中性子で最新の生命現象を読み解く－

  田之倉優; 永田宏次; 宮園健一; 竹下大二郎; 工藤紀雄; 染谷慎一; 宮川拓也, Contributor, pp.165-172

  共立出版, 2010, Not refereed

  

Industrial Property Rights

• 特開2020-152644, VNARのリフォールディング方法およびVNARの製造方法

  竹田 浩之; 澤崎 達也; 宮川 拓也; 田之倉 優

  
• 特許6325978, 特願2013-265666, 新規なクチナーゼ、クチナーゼをコードする遺伝子、及びクチナーゼを用いたポリエステル又はエステル化合物の分解方法

  宮川 拓也; 水嶋 裕樹; 河合 富佐子; 田之倉 優

  
• WO2017-119514 A1, 4-ヒドロキシイソロインの(2S,3R,4S)体及び(2S,3S,4R)体の製造方法

  田之倉 優; 宮川 拓也; 石 玄

  
• WO2015-137501 A1, レチノイン酸産生剤

  浅見 幸夫; 狩野 宏; 牧野 聖也; 伊藤 裕之; 八村 敏志; 田之倉 優; 宮川 拓也; 朴 知賢

  

Awards

• 26 Mar. 2015

  日本農芸化学会, 農芸化学奨励賞
• 30 Jul. 2014

  IUBMB Symposium 18th International Symposium on Flavins and Flavoproteins, Wiley FEBS Journal's Best Poster Award
• 10 Nov. 2011

  Frontiers in Agriculture Proteome Research 2011, Best Poster Award
• 02 Sep. 2011

  日本バイオイメージング学会, 奨励賞

External funds: Kakenhi

• 神経膠芽腫治療に向けた革新的な抗体医療技術の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kansai Medical University

  池田 幸樹

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  低分子抗体;ミニチュア化;神経膠芽腫;ADC

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02776/
• Elucidating integration mechanisms of plant nutritional information as a basis for Liebig's minimum law

  Grant-in-Aid for Scientific Research (S)

  Broad Section F

  The University of Tokyo

  柳澤 修一

  From 27 Apr. 2022, To 31 Mar. 2027, Granted

  植物栄養;肥料三要素;リービッヒの最小律;栄養シグナル;転写制御;シグナル伝達;遺伝子発現制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04977/
• Anti-inflammatory mechanisms of food, commensals and metabolites coordinately acting on immune cells in the small intestine

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38050:Food sciences-related

  The University of Tokyo

  八村 敏志

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  腸管;食品;免疫;炎症;腸内細菌;代謝物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02283/
• Elucidation of the cooperative DNA recognition mechanism of transcription factors in brassinosteroid-responsive gene regulation

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38030:Applied biochemistry-related

  Kyoto University;The University of Tokyo

  宮川 拓也

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  植物;ブラシノステロイド;転写調節;転写因子間相互作用;植物ホルモン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02114/
• Elucidating structural basis for the protein complex controlling photoperiod-dependent flowering pathway

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The University of Tokyo

  宮川 拓也

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  植物;花成誘導;光周期応答;蛋白質間相互作用;複合体構造解析;X線結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04855/
• Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Jichi Medical University

  Ryozo Nagai

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  平滑筋ミオシン;家族性大動脈解離;血管老化機構

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02811/
• Regulation of chronic inflammation in aging and adipose tissues via the intestinal immune system by food

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38050:Food sciences-related

  The University of Tokyo

  Satoshi HACHIMURA

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  腸管免疫系;慢性炎症;加齢性炎症;脂肪組織;樹状細胞;制御性T細胞;機能性食品;食品;マクロファージ;腸管バリア;加齢

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02152/
• 生殖過程の転写制御を担う鍵ホルダー分子DELLAと転写因子の複合体構造基盤解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The University of Tokyo

  宮川 拓也

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  植物;花成誘導;転写因子;X線結晶構造解析;蛋白質間相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H05835/
• Neuronal differentiation of MUSE cells mediated by neuronal differentiation control peptides and application to neuronal regeneration medicine

  Grant-in-Aid for Scientific Research (C)

  International University of Health and Welfare;Yokohama City University

  Hiroshi Kanno

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  MUSE細胞;幹細胞;神経分化誘導;BCボックスモチーフ;再生医療;ＢＣボックスモチーフ;ＶＨＬ;ＪＡＫ／ＳＴＡＴ;多能性組織幹細胞;皮膚由来前駆細胞;体性幹細胞;神経再生医療;VHL;神経分化誘導ペプチド;多能性体性幹細胞;BC-boxモチーフ;多能性幹細胞;神経再生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10366/
• Selective regulation of salicylic acid signaling for inducing the systemic acquired resistance of various crops

  Grant-in-Aid for Young Scientists (A)

  The University of Tokyo

  Takuya Miyakawa

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  植物ホルモン;サリチル酸;抵抗性誘導剤;X線結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05621/
• Vibrational spectroscopic studies on Ca2+-binding function of Ca2+-binding proteins

  Grant-in-Aid for Scientific Research (C)

  Tokyo Medical and Dental University

  Masayuki Nara

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  赤外分光;カルシウム結合タンパク質;合成ペプチドアナログ;配位構造;凝集;カルシウム;構造機能相関;赤外分光法;振動計算;同位体ラベル;ラマン分光法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26410005/
• Effects of Change in Purine Metabolism on Accumulation of Aggregated Proteins in the Cell

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  Takeshi NISHINO

  From 01 Apr. 2012, To 31 Mar. 2013, Project Closed

  筋萎縮性側索硬化症;キサンチン酸化還元酵素;抗痛風剤;活性酸素;抗痛風薬;プリン代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659144/
• Elucidation of aging regulatory mechanisms related to mitochondrial function and identification of anti-aging food factors

  Grant-in-Aid for Scientific Research (S)

  The University of Tokyo

  Masaru TANOKURA

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  老化;抗老化;ミトコンドリア;食品;食物質;ミトコンドリ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23228003/
• X-ray crystallography of abscisic acid transporter

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  Takuya MIYAKAWA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  X線結晶解析;生物物理;植物;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23770104/
• Multiple co-working system to regulate plant growth via brassinosteroid signaling networks

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  中野 雄司

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00502/
• 神経膠芽腫治療に向けた革新的な抗体医療技術の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University;Kansai Medical University

  池田 幸樹

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  インテグリン;VNAR抗体;ミニチュア抗体;低分子抗体;ミニチュア化;神経膠芽腫;ADC

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27467/
• Anti-inflammatory mechanisms of food, commensals and metabolites coordinately acting on immune cells in the small intestine

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38050:Food sciences-related

  The University of Tokyo

  八村 敏志

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  腸管;食品;免疫;炎症;腸内細菌;代謝物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23550/

External funds: others

• コムギ無細胞系とAirIDを基盤とした複合体生産・探索・解析技術の支援と高度化

  日本医療研究開発機構（AMED）, 生命科学・創薬研究支援基盤事業

  From 01 Apr. 2022, To 31 Mar. 2027

  澤崎 達也

  研究分担者
• サメVNAR作製プラットフォームを基盤とした次世代抗体医薬品の開発技術高度化

  日本医療研究開発機構（AMED）, 次世代治療・診断実現のための創薬基盤技術開発事業

  From 01 Apr. 2021, To 31 Mar. 2026

  竹田 浩之

  研究分担者
• コムギ無細胞系による構造解析に適した複合体タンパク質生産・調製技術と低分子抗体作製技術の創出

  日本医療研究開発機構（AMED）, 創薬等ライフサイエンス研究支援基盤事業

  From 01 Apr. 2017, To 31 Mar. 2022

  澤崎達也

  研究分担者
• 国産和牛肉の新たな差別化のための評価指標及び育種手法の開発

  農業・食品産業技術総合研究機構（NARO）, 革新的技術開発・緊急展開事業（うち先導プロジェクト包括提案型）

  From 01 Apr. 2016, To 31 Mar. 2021

  小林栄治

  研究分担者

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Biology and Life Science

  N484, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Practice of Basic Informatics (Faculty of Agriculture)

  T007, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course in Plant Biology

  1028, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Integrated Life Sciences

  5012, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Integrated Life Sciences

  5012, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Plant Biochemistry and Physiology

  5673, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Plant Biochemistry I

  5650, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Plant Biology

  1028, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Plant Biochemistry and Physiology

  5673, Year-long, Faculty of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Integrated Life Sciences

  5012, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Integrated Life Sciences

  5012, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Plant Biochemistry I

  5650, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Plant Biochemistry and Physiology

  5673, Year-long, Faculty of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Plant Biochemistry I

  5650, Fall, Faculty of Agriculture, 2

Participation in PhD Defenses (other than KU)

• TGF-βシグナル伝達系の抑制に関わるSMAD2/3-TMEPAI複合体の研究

  楠林和貴, 東京大学, Sub-chief Examiner

  09 Jan. 2024
• 炎症抑制効果を持つ酸菌の腸管バリア増強機能における腸内細菌との協調作用の解明

  王禕玫, 東京大学, Sub-chief Examiner

  10 Jan. 2023

Part-time lecturer

• From 11 Apr. 2022, To 31 Mar. 2025

  生物物理化学

  千葉大学, 理学部
• From 14 Sep. 2022, To 31 Mar. 2023

  生命科学研究法3

  学習院大学, 理学部
• From 01 Apr. 2021, To 31 Mar. 2023

  一般化学T

  東京医科歯科大学, 教養部
• From 01 Apr. 2021, To 31 Mar. 2022

  サイエンスPBL入門

  東京医科歯科大学, 教養部
• From 01 Aug. 2018, To 30 Sep. 2018

  応用化学特別講義II

  愛媛大学, 工学部
• From 06 Apr. 2015, To 27 Sep. 2015

  分子生物工学

  埼玉大学, 工学部

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  環境管理専門委員会有機廃液情報管理小委員会

Academic, Social Contribution

Committee Memberships

• From Jan. 2013, To Present

  評議員, 日本バイオイメージング学会
• From Apr. 2014, To Mar. 2020

  専門調査員, 文部科学省科学技術・学術政策研究所
• From Dec. 2017, To Feb. 2020

  2019年度大会 実行委員, 日本農芸化学会
• From May 2015, To Mar. 2016

  第11回学術大会 実行委員, 日本食品免疫学会
• From Apr. 2014, To Mar. 2015

  平成26年度年会 実行委員, 日本結晶学会
• From Oct. 2013, To Feb. 2015

  2014年度大会 実行委員, 日本農芸化学会