Basic Information

Faculty

• 農学部

Professional Memberships

• 日本薬学会構造活性相関部会
• アメリカ化学会(American Chemical Society)
• 日本応用動物昆虫学会
• 日本農薬学会
• 日本農芸化学会

Academic Degree

• 農学修士(京都大学)
• 農学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院農学研究科修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 京都府立大学, 農学部農芸化学科, 卒業

Research History

• From 1983

  - 京都大学大学院農学研究科

Language of Instruction

• English

ID,URL

• J-Global ID

  200901052982855215

• External link

  http://www.seicho.kais.kyoto-u.ac.jp/personal/nakagawa.html

researchmap URL

• https://researchmap.jp/read0013054

Research

Research Topics, Overview of the research

• Research Topics

  Structure-activity relationship of insect growth disruptors
  Structure activity relationship of brassinosteroids
  In silico screening of non-steroidal ecdysone and brassinolide agonists.
  Scorpion toxins

• Overview of the research

  昆虫特異的な生理現象である脱皮・変態を阻害する剤，いわゆる昆虫成育制御剤の構造活性相関研究を中心とした研究を行っている．特に，脱皮ホルモン様活性化合物については，その受容体タンパク質の遺伝子クローニングを行って，タンパク質の合成も行った．それ以外に，サソリの毒液に含まれる毒素の探索と構造決定，植物に含まれるステロイドホルモンの作用を模倣する化合物の分子設計を行っている．2013年から，昆虫のキチン合成阻害剤ベンゾイルフェニルウレアの作用機構研究を開始した．

Research Interests

• 農薬化学
• Pesticide Chemistry

Research Areas

• Life sciences, Bioorganic chemistry

Papers

• Genome-wide Identification of Tebufenozide Resistant Genes in the smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae).

  Miwa Uchibori-Asano; Akiya Jouraku; Toru Uchiyama; Kakeru Yokoi; Gaku Akiduki; Yoshitaka Suetsugu; Tetsuya Kobayashi; Akihito Ozawa; Saki Minami; Chiharu Ishizuka; Yoshiaki Nakagawa; Takaaki Daimon; Tetsuro Shinoda

  Scientific reports, 12 Mar. 2019, Peer-reviewed

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• Structure-based virtual screening for insect ecdysone receptor ligands using MM/PBSA

  NAKAGAWA Yoshiaki

  Bioorg. Med. Chem., Mar. 2019, Peer-reviewed

  
• Asymmetric synthesis of tetrahydroquinoline-type ecdysone agonists and QSAR for their binding affinity against Aedes albopictus ecdysone receptors

  NAKAGAWA Yoshiaki

  Pest Manag. Sci.,, Jan. 2019, Peer-reviewed

  
• Asymmetric synthesis of tetrahydroquinoline-type ecdysone agonists and a QSAR of their binding affinity against Aedes albopictus ecdysone receptors

  NAKAGAWA Yoshiaki

  Pest Manag. Sci., 2019, Peer-reviewed

  
• Chemical synthesis of a two-domain scorpion toxin LaIT2 and its single-domain analogs to elucidate structural factors important for insecticidal and antimicrobial activities.

  Juichi H; Ando R; Ishido T; Miyashita M; Nakagawa Y; Miyagawa H

  Journal of peptide science : an official publication of the European Peptide Society, Dec. 2018, Peer-reviewed

  
• Editorial.

  Nakagawa Y

  Journal of pesticide science, Aug. 2018, Peer-reviewed

  
• Preface to the Special Issue: Brief review of plant hormones and their utilization in agriculture.

  NAKAGAWA Yoshiaki

  Journal of Pesticide Science, Aug. 2018, Peer-reviewed, Invited

  
• Synthesis and inhibitory activity of mechanism-based 4-coumaroyl-CoA ligase inhibitors

  Bunta Watanabe; Hiroaki Kirikae; Takao Koeduka; Yoshinori Takeuchi; Tomoki Asai; Yoshiyuki Naito; Hideya Tokuoka; Shinri Horoiwa; Yoshiaki Nakagawa; Bun-ichi Shimizu; Masaharu Mizutani; Jun Hiratake

  Bioorganic and Medicinal Chemistry, 15 May 2018, Peer-reviewed

  
• Quantitative structure-activity relationship of substituted imidazothiadiazoles for their binding against the ecdysone receptor of Sf-9 cells

  Taiyo Yokoi; Yoshiaki Nakagawa; Hisashi Miyagawa

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Dec. 2017, Peer-reviewed

  
• Complete de novo sequencing of antimicrobial peptides in the venom of the scorpion Isometrus maculatus

  Masahiro Miyashita; Atsushi Kitanaka; Mao Yakio; Yuzo Yamazaki; Yoshiaki Nakagawa; Hisashi Miyagawa

  TOXICON, Dec. 2017, Peer-reviewed

  
• Brassinolide-like activity of castasterone analogs with varied side chains against rice lamina inclination

  Bunta Watanabe; Shuji Yamamoto; Taiyo Yokoi; Airi Sugiura; Shinri Horoiwa; Takanori Aoki; Hisashi Miyagawa; Yoshiaki Nakagawa

  BIOORGANIC & MEDICINAL CHEMISTRY, Sep. 2017, Peer-reviewed

  
• New reporter gene assays for detecting natural and synthetic molting hormone agonists using yeasts expressing ecdysone receptors of various insects.

  NAKAGAWA Yoshiaki

  FEBS Open Bio, 2017, Peer-reviewed

  
• Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom

  Mohammed Abdel-Wahab; Masahiro Miyashita; Yoshiyuki Ota; Hironori Juichi; Ryota Okabe; Moustafa Sarhan; Maged Fouda; Mohamed Abdel-Rahman; Samy Saber; Yoshiaki Nakagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, Peer-reviewed

  
• Discovery of a nonsteroidal brassinolide-like compound, NSBR1

  Airi Sugiura; Shinri Horoiwa; Takanori Aoki; Seisuke Takimoto; Ayumi Yamagami; Takeshi Nakano; Yoshiaki Nakagawa; Hisashi Miyagawa

  JOURNAL OF PESTICIDE SCIENCE, 2017, Peer-reviewed

  
• In silico exploration for agonists/antagonists of brassinolide

  Seisuke Takimoto; Airi Sugiura; Saki Minami; Tomohiko Tasaka; Yoshiaki Nakagawa; Hisashi Miyagawa

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Apr. 2016, Peer-reviewed

  
• Characterization of the venom of the vermivorous cone snail Conus fulgetrum

  Mohammed Abdel-Wahab; Masahiro Miyashita; Atsushi Kitanaka; Hironori Juichi; Moustafa Sarhan; Maged Fouda; Mohamed Abdel-Rahman; Samy Saber; Yoshiaki Nakagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2016, Peer-reviewed

  
• Structure-activity relationship of imidazothiadiazole analogs for the binding to the ecdysone receptor of insect cells

  Taiyo Yokoi; Saki Minami; Yoshiaki Nakagawa; Hisashi Miyagawa

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, May 2015, Peer-reviewed

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• Substituent Effect on the Thermodynamic Solubility of Structural Analogs: Relative Contribution of Crystal Packing and Hydration

  Shunsuke Ozaki; Yoshiaki Nakagawa; Osamu Shirai; Kenji Kano

  JOURNAL OF PHARMACEUTICAL SCIENCES, Nov. 2014, Peer-reviewed

  
• Crystallization and preliminary X-ray diffraction studies of La1 from Liocheles australasiae

  Saori Kamachi; Junya Nagao; Masahiro Miyashita; Yoshiaki Nakagawa; Hisashi Miyagawa; Toshiji Tada

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Jul. 2014, Peer-reviewed

  
• RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling

  Ken'ichiro Hayashi; Bunta Watanabe; Yoshiaki Nakagawa; Saki Minami; Tsuyoshi Morita

  PLOS ONE, Feb. 2014, Peer-reviewed

  
• Sorption and quantitative structure-activity relationship (QSAR)

  NAKAGAWA Yoshiaki

  ACS Symposium Series, 2014, Peer-reviewed

  
• Biodegradation and quantitative structure-activity relationship (QSAR).

  NAKAGAWA Yoshiaki

  ACS Symposium Series, 2014, Peer-reviewed

  
• cDNA cloning of ecdysone receptor (EcR) and ultraspiracle (USP) from Harmonia axyridis and Epilachna vigintioctopunctata and the evaluation of the binding affinity of ecdysone agonists to the in vitro translated EcR/USP heterodimers

  China Morishita; Chieka Minakuchi; Taiyo Yokoi; Seisuke Takimoto; Akifumi Hosoda; Miki Akamatsu; Hioto Tamura; Yoshiaki Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 2014, Peer-reviewed

  
• Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agro chemicals (vol 38, pg 112, 2013)

  Satoshi Kanaoka; Yasuhisa Kimura; Masaaki Fujikawa; Yoshiaki Nakagawa; Kazumitsu Ueda; Mild Akamatsu

  JOURNAL OF PESTICIDE SCIENCE, 2014, Peer-reviewed

  
• Structural requirement and stereospecificity of tetrahydroquinolines as potent ecdysone agonists

  S. Kitamura; T. Harada; H. Hiramatsu; R. Shimizu; H. Miyagawa; Y. Nakagawa

  Bioorganic and Medicinal Chemistry Letters, 2014, Peer-reviewed

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• A new dibenzoylhydrazine with insecticidal activity against Anopheles mosquito larvae

  Evangelia Morou; Manolis Lirakis; Nena Pavlidi; Moises Zotti; Yoshiaki Nakagawa; Guy Smagghe; John Vontas; Luc Swevers

  PEST MANAGEMENT SCIENCE, Jul. 2013, Peer-reviewed

  
• Isolation and Characterization of an Anti-Insect beta-Toxin from the Venom of the Scorpion Isometrus maculatus

  Tomoyuki Kawachi; Masahiro Miyashita; Yoshiaki Nakagawa; Hisashi Miyagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jan. 2013, Peer-reviewed

  
• Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agro chemicals

  Satoshi Kanaoka; Yasuhisa Kimura; Masaaki Fujikawa; Yoshiaki Nakagawa; Kazumitsu Ueda; Miki Akamatsu

  JOURNAL OF PESTICIDE SCIENCE, 2013, Peer-reviewed

  
• Isolation and Characterization of a Novel Non-Selective beta-Toxin from the Venom of the Scorpion Isometrus maculatus

  Yayoi Ichiki; Tomoyuki Kawachi; Masahiro Miyashita; Yoshiaki Nakagawa; Hisashi Miyagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2012, Peer-reviewed

  
• Quantitative evaluation of the molting hormone activity in coleopteran cells established from the Colorado potato beetle, Leptinotarsa decemlineata

  Takehiko Ogura; Yoshiaki Nakagawa; Luc Swevers; Guy Smagghe; Hisashi Miyagawa

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Sep. 2012, Peer-reviewed

  
• Structure-Activity Relationships of Ecdysteroids and Non-Steroidal Ecdysone Agonists

  Laurence Dinan; Yoshiaki Nakagawa; Robert E. Hormann

  ADVANCES IN INSECT PHYSIOLOGY, VOL 43: INSECT GROWTH DISRUPTORS, 2012, Peer-reviewed

  
• LC/MS/MS identification of 20-hydroxyecdysone in a scorpion (Liocheles australasiae) and its binding affinity to in vitro-translated molting hormone receptors

  Masahiro Miyashita; Kaori Matsushita; Shunsuke Nakamura; Sho Akahane; Yoshiaki Nakagawa; Hisashi Miyagawa

  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Dec. 2011, Peer-reviewed

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• Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae

  Shoichiro Horita; Nobuto Matsushita; Tomoyuki Kawachi; Reed Ayabe; Masahiro Miyashita; Takuya Miyakawa; Yoshiaki Nakagawa; Koji Nagata; Hisashi Miyagawa; Masaru Tanokura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2011, Peer-reviewed

  
• Virtual Screening for Ligands of the Insect Molting Hormone Receptor

  Toshiyuki Harada; Yoshiaki Nakagawa; Takehiko Ogura; Yutaka Yamada; Takehiro Ohe; Hisashi Miyagawa

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, Feb. 2011, Peer-reviewed

  
• Erratum: Arthropod nuclear receptors and their role in molting (FEBS Journal (2009) 276 (6128-6157))

  Y. Nakagawa; V.C. Henrich

  FEBS Journal, 2011, Peer-reviewed

  
• Comparison of the activity of non-steroidal ecdysone agonists between dipteran and lepidopteran insects, using cell-based EcR reporter assays

  Thomas Soin; Luc Swevers; Georgia Kotzia; Kostas Iatrou; Colin R. Janssen; Pierre Rouge; Toshiyuki Harada; Yoshiaki Nakagawa; Guy Smagghe

  PEST MANAGEMENT SCIENCE, Nov. 2010, Peer-reviewed

  
• Characterization of Juvenile Hormone Epoxide Hydrolase and Related Genes in the Larval Development of the Silkworm Bombyx mori

  Atsushi Seino; Takehiko Ogura; Takuya Tsubota; Masaru Shimomura; Takayo Nakakura; Anjiang Tan; Kazuei Mita; Tetsuro Shinoda; Yoshiaki Nakagawa; Takahiro Shiotsuki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2010, Peer-reviewed

  
• Assessment of species specificity of moulting accelerating compounds in Lepidoptera: comparison of activity between Bombyx mori and Spodoptera littoralis by in vitro reporter and in vivo toxicity assays

  Thomas Soin; Ellen De Geyter; Hadi Mosallanejad; Masatoshi Iga; David Martin; Shunsuke Ozaki; Shigeki Kitsuda; Toshiyuki Harada; Hisashi Miyagawa; Dimitra Stefanou; Georgia Kotzia; Rodica Efrose; Vassiliki Labropoulou; Danny Geelen; Kostas Iatrou; Yoshiaki Nakagawa; Colin R. Janssen; Guy Smagghe; Luc Swevers

  PEST MANAGEMENT SCIENCE, May 2010, Peer-reviewed

  
• A Novel Amphipathic Linear Peptide with Both Insect Toxicity and Antimicrobial Activity from the Venom of the Scorpion Isometrus maculatus

  Masahiro Miyashita; Atsushi Sakai; Nobuto Matsushita; Yosuke Hanai; Yoshiaki Nakagawa; Hisashi Miyagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Feb. 2010, Peer-reviewed

  
• Characterization of juvenile hormone epoxide hydrolase and its telated genes in larval development of silkworm, Bombyx mori

  Seino A; Ogura T; Tsubota T; Shimomura M; Nakakura T; Tan A; Mita K; Shinoda T; Nakagawa Y; Shiotsuki T

  Biosci Biotech Biochem 74: 1421-1429, 2010, Peer-reviewed

  
• Carboxylesterases - from function to the field: an overview of carboxylesterase biochemistry, structure-activity relationship, and use in environmental field monitoring

  Craig E. Wheelock; Yoshiaki Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 2010, Peer-reviewed

  
• Purification and cDNA Cloning of LaIT2, a Novel Insecticidal Toxin from Venom of the Scorpion Liocheles australasiae

  Nobuto Matsushita; Masahiro Miyashita; Yayoi Ichiki; Takehiko Ogura; Eiji Sakuradani; Yoshiaki Nakagawa; Sakayu Shimizu; Hisashi Miyagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Dec. 2009, Peer-reviewed

  
• Purification and cDNA Cloning of LaIT2, a Novel Insecticidal Toxin from Venom of the Scorpion Liocheles australasiae

  Nobuto Matsushita; Masahiro Miyashita; Yayoi Ichiki; Takehiko Ogura; Eiji Sakuradani; Yoshiaki Nakagawa; Sakayu Shimizu; Hisashi Miyagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Dec. 2009, Peer-reviewed

  
• Mycolyltransferase from Mycobacterium leprae Excludes Mycolate-containing Glycolipid Substrates

  Hitomi Nakao; Isamu Matsunaga; Daisuke Morita; Takako Aboshi; Toshiyuki Harada; Yoshiaki Nakagawa; Naoki Mori; Masahiko Sugita

  JOURNAL OF BIOCHEMISTRY, Nov. 2009, Peer-reviewed

  
• Arthropod nuclear receptors and their role in molting

  Yoshiaki Nakagawa; Vincent C. Henrich

  FEBS JOURNAL, Nov. 2009, Peer-reviewed

  
• Evaluation of hydrogen bonds of ecdysteroids in the ligand-receptor interactions using a protein modeling system

  Toshiyuki Harada; Yoshiaki Nakagawa; Miki Akamatsu; Hisashi Miyagawa

  BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2009, Peer-reviewed

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• Properties of ecdysteroid receptors from diverse insect species in a heterologous cell culture system - a basis for screening novel insecticidal candidates

  Joshua M. Beatty; Guy Smagghe; Takehiko Ogura; Yoshiaki Nakagawa; Margarethe Spindler-Barth; Vincent C. Henrich

  FEBS JOURNAL, Jun. 2009, Peer-reviewed

  
• Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis

  Toshiyuki Harada; Yoshiaki Nakagawa; Randy M. Wadkins; Philip M. Potter; Craig E. Wheelock

  BIOORGANIC & MEDICINAL CHEMISTRY, Jan. 2009, Peer-reviewed

  
• A New Accounting System for Financial Balance Based on Personnel Cost after the Introduction of a DPC/DRG System

  Yoshiaki Nakagawa; Tadamasa Takemura; Hiroyuki Yoshihara; Yoshinobu Nakagawa

  Journal of Medical Systems; (Online), 2009, Peer-reviewed

  
• The simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a bryostatin-like PKCδ activator having the aplysiatoxin skeleton

  Nakagawa, Y; Yanagita, R. C; Hamada, N; Murakami, A; Takahashi, H; Saito, N; Nagai, H; Irie, K

  J. Am. Chem. Soc., 131(22); 7573?7579, 2009, Peer-reviewed

  
• Synthesis of ponasterone A derivatives with various steroid skeleton moieties and evaluation of their binding to the ecdysone receptor of Kc cells

  Hirokazu Arai; Bunta Watanabe; Yoshiaki Nakagawa; Hisashi Miyagawa

  STEROIDS, Dec. 2008, Peer-reviewed

  
• Trans-species activation of human T cells by rhesus macaque CD1b molecules

  Daisuke Morita; Kumiko Katoh; Toshiyuki Harada; Yoshiaki Nakagawa; Isamu Matsunaga; Tomoyuki Miura; Akio Adachi; Tatsuhiko Igarashi; Masahiko Sugita

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2008, Peer-reviewed

  
• Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I)

  Naoya Ichimaru; Masatoshi Murai; Nobuyuki Kakutani; Junko Kako; Atsushi Ishihara; Yoshiaki Nakagawa; Takaaki Nishioka; Takao Yagi; Hideto Miyoshi

  BIOCHEMISTRY, Oct. 2008, Peer-reviewed

  
• Non-steroidal ecdysteroid agonist chromafenozide: Gene induction activity, cell proliferation inhibition and larvicidal activity

  Hadi Mosallanejad; Thomas Soin; Luc Swevers; Kostas Iatrou; Yoshiaki Nakagawa; Guy Smagghe

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Oct. 2008, Peer-reviewed

  
• Multidimensional quantitative structure - Activity relationships of diacylhydrazine toxicity to lepidopteran and coleopteran insect pests

  Robert E. Hormann; Guy Smagghe; Yoshiaki Nakagawa

  QSAR & COMBINATORIAL SCIENCE, Sep. 2008, Peer-reviewed

  
• Multidimensional quantitative structure-activity relationships of diacylhydrazine toxicity in Spodoptera exigua, Chilo suppressalis, and Leptinotarsa decemlineata.

  Hormann RE; Smagghe G; Nakagawa Y

  QSAR Comb. Sci. 27: 1098-1112, 2008, Peer-reviewed

  
• Molecular cloning of the ecdysone receptor and the retinoid X receptor from the scorpion Liocheles australasiae

  Yoshiaki Nakagawa; Atsushi Sakai; Fumie Magata; Takehiko Ogura; Masahiro Miyashita; Hisashi Miyagawa

  FEBS JOURNAL, Dec. 2007, Peer-reviewed

  
• Purification and characterization of a novel short-chain insecticidal toxin with two disulfide bridges from the venom of the scorpion Liocheles australasiae

  Nobuto Matsushita; Masahiro Miyashita; Atsushi Sakai; Yoshiaki Nakagawa; Hisashi Miyagawa

  TOXICON, Nov. 2007, Peer-reviewed

  
• Characterization of peptide components in the venom of the scorpion Liocheles australasiae (Hemiscorpiidae)

  Masahiro Miyashita; Junko Otsuki; Yosuke Hanai; Yoshiaki Nakagawa; Hisashi Miyagawa

  TOXICON, Sep. 2007, Peer-reviewed

  
• Effects of the structures of ecdysone receptor (EcR) and ultraspiracle (USP) on the ligand-binding activity of the EcR/USP heterodimer

  Chieka Minakuchi; Takehiko Ogura; Hisashi Miyagawa; Yoshiaki Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 2007, Peer-reviewed

  
• Structure-activity relationship and mode of action study of insect growth regulators

  Yoshiaki Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 2007, Peer-reviewed

  
• QSAR and mode of action studies of insecticidal ecdysone agonists

  T. Fujita; Y. Nakagawa

  SAR AND QSAR IN ENVIRONMENTAL RESEARCH, Jan. 2007, Peer-reviewed

  
• Corrigendum to "estimation of the hydrophobicity of 2,4-diphenyl-1,3-oxazoline analogs and QSAR analysis of their ovicidal activity against Tetranychus urticae". [Bioorg. Med. Chem. Lett. 16 (2006) 4080-4084] (DOI:10.1016/j.bmcl.2006.04.089)

  Chieka Minakuchi; Junji Suzuki; Kazuya Toda; Miki Akamatsu; Yoshiaki Nakagawa

  Bioorganic and Medicinal Chemistry Letters, 15 Oct. 2006, Peer-reviewed

  
• Estimation of the hydrophobicity of 2,4-diphenyl-1,3-oxazoline analogs and QSAR analysis of their ovicidal activity against Tetranycus urticae

  Chieka Minakuchi; Junji Suzuki; Kazuya Toda; Miki Akamatsu; Yoshiaki Nakagawa

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2006, Peer-reviewed

  
• Synthesis of 26,27-bisnorcastasterone analogs and analysis of conformation-activity relationship for brassinolide-like activity

  S Yamamoto; B Watanabe; J Otsuki; Y Nakagawa; M Akamatsu; H Miyagawa

  BIOORGANIC & MEDICINAL CHEMISTRY, Mar. 2006, Peer-reviewed

  
• High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity

  CE Wheelock; Y Nakagawa; T Harada; N Oikawa; M Akamatsu; G Smagghe; D Stefanou; K Iatrou; L Swevers

  BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2006, Peer-reviewed

  
• QSAR of 2,4-diphenyl-1,3-oxazolines for ovicidal activity against the two-spotted spider mite Tetranychus urticae

  Junji Suzuki; Isao Tanji; Yasuhiro Ota; Kazuya Toda; Yoshiaki Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 2006, Peer-reviewed

  
• Molecular cloning, expression analysis and functional confirmation of ecdysone receptor and ultraspiracle from the Colorado potato beetle Leptinotarsa decemlineata

  T Ogura; C Minakuchi; Y Nakagawa; G Smagghe; H Miyagawa

  FEBS JOURNAL, Aug. 2005, Peer-reviewed

  
• Classical and three-dimensional QSAR for the inhibition of [H-3]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells

  Y Nakagawa; K Takahashi; H Kishikawa; T Ogura; C Minakuchi; H Miyagawa

  BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2005, Peer-reviewed

  
• Erratum: Molecular cloning and expression analysis of ultraspiracle (USP) from the rice stem borer Chilo suppressalis (Insect Biochemistry and Molecular Biology (2003) 33 (41-49) PII: S0965-1748(02)00165-0 and DOI: 10.1016/S0965-1748(02)00165-0)

  C. Minakuchi; Y. Nakagawa; M. Kiuchi; A. Seino; S. Tomita; M. Kamimura

  Insect Biochemistry and Molecular Biology, Feb. 2005, Peer-reviewed

  
• Nonsteroidal ecdysone agonists

  Y Nakagawa

  INSECT HORMONES, VOL 73, 2005, Peer-reviewed

  
• QSAR for binding affinity of substituted dibenzoylhydrazines to intact Sf-9 cells

  T Ogura; Y Nakagawa; C Minakuchi; H Miyagawa

  JOURNAL OF PESTICIDE SCIENCE, 2005, Peer-reviewed

  
• Stereoselective synthesis of (22R)- and (22S)-castasterone/ponasterone A hybrid compounds and evaluation of their molting hormone activity

  B Watanabe; Y Nakagawa; T Ogura; H Miyagawa

  STEROIDS, Jul. 2004, Peer-reviewed

  
• Synthesis of brassinosteroids of varying acyl side chains and evaluation of their brassinolide-like activity

  S Uesusuki; B Watanabe; S Yamamoto; J Otsuki; Y Nakagawa; H Miyagawa

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2004, Peer-reviewed

  
• A simple synthesis of 6-deoxoteasterone and its 20-epimer

  B Watanabe; S Yamamoto; K Sasaki; Y Nakagawa; H Miyagawa

  TETRAHEDRON LETTERS, Mar. 2004, Peer-reviewed

  
• A cell-based high-throughput screening system for detecting ecdysteroid agonists and antagonists in plant extracts and libraries of synthetic compounds.

  L. Swevers; L. Kravariti; S. Ciolfi; M. Xenou-Kokoletsi; N. Ragoussis; G. Smagghe; Y. Nakagawa; B. Mazomenos; K. Iatrou

  The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Peer-reviewed

  
• Preparation of functional ecdysteroid receptor proteins (EcR and USP) using a wheat germ cell-free protein synthesis system

  C Minakuchi; Y Nakagawa; Y Soya; H Miyagawa

  JOURNAL OF PESTICIDE SCIENCE, 2004, Peer-reviewed

  
• Metabolism of imidacloprid in houseflies

  H Nishiwaki; K Sato; Y Nakagawa; M Miyashita; H Miyagawa

  JOURNAL OF PESTICIDE SCIENCE, 2004, Peer-reviewed

  
• Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors

  CE Wheelock; Y Nakagawa; M Akamatsu; BD Hammock

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2003, Peer-reviewed

  
• Binding affinity of nonsteroidal ecdysone agonists against the ecdysone receptor complex determines the strength of their molting hormonal activity

  C Minakuchi; Y Nakagawa; M Kamimura; H Miyagawa

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Oct. 2003, Peer-reviewed

  
• Insecticidal activity and nicotinic acetylcholine receptor binding of dinotefuran and its analogues in the housefly, Musca domestica

  K Kiriyama; H Nishiwaki; Y Nakagawa; K Nishimura

  PEST MANAGEMENT SCIENCE, Oct. 2003, Peer-reviewed

  
• Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities

  H Nishiwaki; Y Nakagawa; M Kuwamura; K Sato; M Akamatsu; K Matsuda; K Komai; H Miyagawa

  PEST MANAGEMENT SCIENCE, Sep. 2003, Peer-reviewed

  
• Validity Analysis of a Receptor Binding Assay for Ecdysone Agonists Using Cultured Intact Insect Cells

  中川 好秋

  J. Pesticide Sci.,28, 51-53, 2003, Peer-reviewed

  
• Molecular cloning and expression analysis of ultraspiracle (USP) from the rice stem borer Chilo suppressalis

  中川 好秋

  Chieka Minakuchi, Yoshiaki Nakagawa, Makoto Kiuchi, Atsushi Seino, Shuichiro Tomita, and Manabu Kamimura. Insect Biochem. Molec. Biol.,28/ , 51-53, 2003, Peer-reviewed

  
• Validity analysis of a receptor binding assay for ecdysone agonists using cultured intact insect cells

  C Minakuchi; Y Nakagawa; H Miyagawa

  JOURNAL OF PESTICIDE SCIENCE, 2003, Peer-reviewed

  
• Erratum: Molecular cloning, expression analysis and functional confirmation of two ecdysone receptor isoforms from the rice stem borer Chilo suppressalis (Insect Biochemistry and Molecular Biology (2002) 32 (999-1008) PII: S096517480200036x)

  C. Minakuchi; Y. Nakagawa; M. Kiuchi; S. Tomita; M. Kamimura

  Insect Biochemistry and Molecular Biology, 2003, Peer-reviewed

  
• Molecular cloning and expression analysis of ultraspiracle (USP) from the rice stem borer Chilo suppressalis

  C Minakuchi; Y Nakagawa; M Kiuchi; A Seino; S Tomita; M Kamimura

  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Jan. 2003, Peer-reviewed

  
• Synthesis of a castasterone/ponasterone hybrid compound and evaluation of its molting hormone-like activity

  B Watanabe; Y Nakagawa; H Miyagawa

  JOURNAL OF PESTICIDE SCIENCE, 2003, Peer-reviewed

  
• Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors

  CE Wheelock; ME Colvin; Uemura, I; MM Olmstead; Sanborn, JR; Y Nakagawa; AD Jones; BD Hammock

  JOURNAL OF MEDICINAL CHEMISTRY, Dec. 2002, Peer-reviewed

  
• Molecular cloning, expression analysis and functional confirmation of two ecdysone receptor isoforms from the rice stem borer Chilo suppressalis

  C Minakuchi; Y Nakagawa; M Kiuchi; S Tomita; M Kamimura

  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Sep. 2002, Peer-reviewed

  
• Nicotinic acetylcholine receptor binding of imidacloprid-related diaza compounds with various ring sizes and their insecticidal activity against Musca domestica

  S Kagabu; H Nishiwaki; K Sato; M Hibi; N Yamaoka; Y Nakagawa

  PEST MANAGEMENT SCIENCE, May 2002, Peer-reviewed

  
• Inhibition of [H-3]ponasterone A binding by ecdysone agonists in the intact Kc cell line

  Y Nakagawa; C Minakuchi; K Takahashi; T Ueno

  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Feb. 2002, Peer-reviewed

  
• Quantitative structure-activity studies of insect growth regulators: XIX. Effects of substituents on the aromatic moiety of dibenzoylhydrazines on larvicidal activity against the beet armyworm Spodoptera exigua

  Y Nakagawa; G Smagghe; L Tirry; T Fujita

  PEST MANAGEMENT SCIENCE, Feb. 2002, Peer-reviewed

  
• QSAR of insect molting hormone agonists – Classical QSAR.

  中川 好秋

  Yoshiaki Nakagawa. SAR News,3, 5-9, 2002, Peer-reviewed

  
• Insecticidal and binding activities of N3-substituted imidacloprid derivatives against the housefly Musca domestica and the alpha-bungarotoxin binding sites of nicotinic acetylcholine receptors

  H Nishiwaki; Y Nakagawa; T Ueno; S Kagabu; K Nishimura

  PEST MANAGEMENT SCIENCE, Sep. 2001, Peer-reviewed

  
• Quantitative structure-activity studies of insect growth regulators: XVIII. Effects of substituents on the aromatic moiety of dibenzoylhydrazines on larvicidal activity against the Colorado potato beetle Leptinotarsa decemlineata

  Y Nakagawa; G Smagghe; M Van Paemel; L Tirry; T Fujita

  PEST MANAGEMENT SCIENCE, Sep. 2001, Peer-reviewed

  
• Book review of “Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor (ed. I. Yamamoto and J. E. Casida)

  中川 好秋

  Yoshiaki Nakagawa Pest Manag. Sci.,57, 102, 2001, Peer-reviewed

  
• Erratum: 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues (Bioorg. Med. Chem. 8 (2000) 2663) PII: S096808960000198X)

  Yoshiaki Nakagawa; Craig E. Wheelock; Christophe Morisseau; Marvin H. Goodrow; Bruce G. Hammock; Bruce D. Hammock

  Bioorganic and Medicinal Chemistry, 2001, Peer-reviewed

  
• Effects of synergists on the insecticidal activity of chloronicotinyl-related benzyl compounds against houseflies

  H Nishiwaki; Y Nakagawa; T Ueno; K Nishimura

  JOURNAL OF PESTICIDE SCIENCE, 2001, Peer-reviewed

  
• Binding affinity of the methyl ester of AK-toxin I to membrane fractions from Japanese pear leaves

  M Okada; H Miyagawa; Y Nakagawa; T Ueno

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2000, Peer-reviewed

  
• 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues

  Y Nakagawa; CE Wheelock; C Morisseau; MH Goodrow; BG Hammock; BD Hammock

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2000, Peer-reviewed

  
• Binding activity of substituted benzyl derivatives of chloronicotinyl insecticides to housefly-head membranes, and its relationship to insecticidal activity against the housefly Musca domestica

  H Nishiwaki; Y Nakagawa; DY Takeda; A Okazawa; M Akamatsu; H Miyagawa; T Ueno; K Nishimura

  PEST MANAGEMENT SCIENCE, Oct. 2000, Peer-reviewed

  
• Inhibition of [H-3]ponasterone A binding by ecdysone agonists in the intact Sf-9 cell line

  Y Nakagawa; C Minakuchi; T Ueno

  STEROIDS, Sep. 2000, Peer-reviewed

  
• Three-dimensional quantitative structure-activity relationship analysis of acyclic and cyclic chloronicotinyl insecticides

  A Okazawa; M Akamatsu; H Nishiwaki; Y Nakagawa; H Miyagawa; K Nishimura; T Ueno

  PEST MANAGEMENT SCIENCE, Jun. 2000, Peer-reviewed

  
• Relationships between structure and molting hormonal activity of tebufenozide, methoxyfenozide, and their analogs in cultured integument system of Chilo suppressalis Walker

  Y Nakagawa; K Hattori; C Minakuchi; S Kugimiya; T Ueno

  STEROIDS, Mar. 2000, Peer-reviewed

  
• Erratum to “3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues”: [Bioorg. Med. Chem. 8 (2000) 2663].

  中川 好秋

  Yoshiaki Nakagawa, Craig E. Wheelock, Christophe Morisseau, Marvin H. Goodrow, Bruce G. Hammock, and Bruce D. Hammock. Bioorg. Med. Chem.,9, 1941, 2000, Peer-reviewed

  
• Comparison of the binding activities of chloronicotinyl insecticides toward the nicotinic acetylcholine receptors from rats and houseflies

  A Okazawa; Y Nakagawa; M Akamatsu; T Ueno; K Nishimura

  JOURNAL OF PESTICIDE SCIENCE, 2000, Peer-reviewed

  
• Comparison of the binding activities of chloronicotinyl insecticides including imidacloprid, acetamiprid and nitenpyram toward the nicotinic acetylcholine receptors from rats and houseflies.

  中川 好秋

  Atsushi Okazawa, Yoshiaki Nakagawa, Miki Akamatsu, Tamio Ueno and Keiichirou Nishimura. J. Pesticide Sci.,25, 40-43, 2000, Peer-reviewed

  
• Structure-activity relationships of RGD mimetics as fibrinogen-receptor antagonists

  M Miyashita; M Akamatsu; H Ueno; Y Nakagawa; K Nishimura; Y Hayashi; Y Sato; T Ueno

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 1999, Peer-reviewed

  
• Quantitative structure-activity studies of insect growth regulators: XVI. Substituent effects of dibenzoylhydrazines on the insecticidal activity to Colorado potato beetle Leptinotarsa decemlineata

  Y Nakagawa; G Smagghe; S Kugimiya; K Hattori; T Ueno; L Tirry; T Fujita

  PESTICIDE SCIENCE, Sep. 1999, Peer-reviewed

  
• Comparative ecdysteroid action of ring-substituted dibenzoylhydrazines in Spodoptera exigua

  G Smagghe; Y Nakagawa; B Carton; AK Mourad; T Fujita; L Tirry

  ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1999, Peer-reviewed

  
• Prediction of the binding mode of imidacloprid and related compounds to house-fly head acetylcholine receptors using three-dimensional QSAR analysis

  A Okazawa; M Akamatsu; A Ohoka; H Nishiwaki; WJ Cho; Y Nakagawa; K Nishimura; T Ueno

  PESTICIDE SCIENCE, Oct. 1998, Peer-reviewed

  
• Quantitative structure-activity studies of insect growth regulators XIV. Three-dimensional quantitative structure-activity relationship of ecdysone agonists including dibenzoylhydrazine analogs

  Y Nakagawa; K Hattori; B Shimizu; M Akamatsu; H Miyagawa; T Ueno

  PESTICIDE SCIENCE, Aug. 1998, Peer-reviewed

  
• News ----- Report of 9th International Congress of Pesticide Chemistry (In Japanese)

  中川 好秋

  Yoshiaki Nakagawa, Nippon Nogeikagaku Kaishi,72(12), 1475-1476, 1998, Peer-reviewed

  
• Structures and biological activities of phytotoxins produced by the plant pathogenic fungus Bipolaris cynodontis cynA

  CH Lim; H Miyagawa; M Akamatsu; Y Nakagawa; T Ueno

  JOURNAL OF PESTICIDE SCIENCE, 1998, Peer-reviewed

  
• Rapid purification and molecular modeling of AalT peptides from venom of Androctonus australis

  Y Nakagawa; M Sadilek; E Lehmberg; R Herrmann; R Herrmann; H Moskowitz; YM Lee; BA Thomas; R Shimizu; M Kuroda; AD Jones; BD Hammock

  ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1998, Peer-reviewed

  
• Molting hormonal and larvicidal activities of aliphatic acyl analogs of dibenzoylhydrazine insecticides

  B Shimizu; Y Nakagawa; K Hattori; K Nishimura; N Kurihara; T Ueno

  STEROIDS, Oct. 1997, Peer-reviewed

  
• Anti-insect toxin 5 (AaIT5) from Androctonus australis

  Y Nakagawa; YM Lee; E Lehmberg; R Herrmann; R Herrmann; H Moskowitz; AD Jones; BD Hammock

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Jun. 1997, Peer-reviewed

  
• Mode of Action of Benzoylphenylureas(Agrochemistry and Biology Series)

  NAKAGAWA Yoshiaki

  Journal of pesticide science, 20 Nov. 1996, Peer-reviewed

  
• Diflubenzuron stimulates phosphorylation of a 39 kDa integumental protein from newly molted American cockroach (Periplaneta americana)

  Y Nakagawa; S Ishii; F Matsumura

  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Sep. 1996, Peer-reviewed

  
• 昆虫脱皮阻害剤の定量的構造活性相関

  中川 好秋

  日本農薬学会誌, 20 Aug. 1996, Peer-reviewed

  
• Effect of the insect growth regulators, N-tert-butyl-N,N'-dibenzoylhydrazines, on neural activity of the American cockroach

  K Nishimura; T Tada; Y Nakagawa

  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, Jun. 1996, Peer-reviewed

  
• Structural effects of N-arylcarbamoylpyrazolines on calcium uptake in rat brain synaptosomes

  R Hasan; K Nishimura; Y Nakagawa; N Kurihara; T Ueno

  PESTICIDE SCIENCE, Mar. 1996, Peer-reviewed

  
• Quantitative structure-activity relationships of molting inhibitors

  Y Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 1996, Peer-reviewed

  
• Quantitative structure-activity relationships of larvicidal N-[5-(substituted phenyl)-1,3,4-thiadiazol-2-yl]benzamides in the inhibition of N-acetylglucosamine incorporation into a cultured integument system

  Y Nakagawa; K Nishimura; K Izumi; K Kinoshita; T Kimura; N Kurihara; T Fujita

  JOURNAL OF PESTICIDE SCIENCE, 1996, Peer-reviewed

  
• Mode of action of benzoylphenylureas

  Y Nakagawa

  JOURNAL OF PESTICIDE SCIENCE, 1996, Peer-reviewed

  
• QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS AND DESIGNED SYNTHESIS OF LARVICIDAL N,N'-DIBENZOYL-N-TERT-BUTYLHYDRAZINES AGAINST CHILO-SUPPRESSALIS

  Y NAKAGAWA; N OIKAWA; K NISHIMURA; T UENO; T FUJITA

  PESTICIDE SCIENCE, May 1995, Peer-reviewed

  
• ACTIVITY OF ECDYSONE ANALOGS IN ENHANCING N-ACETYLGLUCOSAMINE INCORPORATION INTO THE CULTURED INTEGUMENT OF CHILO-SUPPRESSALIS

  Y NAKAGAWA; K NISHIMURA; N OIKAWA; N KURIHARA; T UENO

  STEROIDS, May 1995, Peer-reviewed

  
• QUANTITATIVE STRUCTURE-ACTIVITY STUDIES OF INSECT GROWTH-REGULATORS .11. STIMULATION AND INHIBITION OF N-ACETYLGLUCOSAMINE INCORPORATION IN A CULTURED INTEGUMENT SYSTEM BY SUBSTITUTED N-TERT-BUTYL-N,N'-DIBENZOYLHYDRAZINES

  Y NAKAGAWA; Y SOYA; K NAKAI; N OIKAWA; K NISHIMURA; T UENO; T FUJITA; N KURIHARA

  PESTICIDE SCIENCE, Apr. 1995, Peer-reviewed

  
• ニュース／藤田稔夫先生のアメリカ化学会農薬化学研究国際賞受賞および受賞記念シンポジウム

  中川 好秋

  中川好秋，日本農芸化学会誌,69(1), 71-73, 1995, Peer-reviewed

  
• News ---- Report of 208th ACS-meeting (In Japanese)

  中川 好秋

  Yoshiaki Nakagawa, Nippon Nogeikagaku Kaishi,69(1), 71-73, 1995, Peer-reviewed

  
• DIFLUBENZURON AFFECTS GAMMA-THIOGTP STIMULATED CA2+ TRANSPORT IN-VITRO IN INTRACELLULAR VESICLES FROM THE INTEGUMENT OF THE NEWLY MOLTED AMERICAN COCKROACH, PERIPLANETA-AMERICANA L

  Y NAKAGAWA; F MATSUMURA

  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Dec. 1994, Peer-reviewed

  
• QUANTITATIVE STRUCTURE-ACTIVITY STUDIES OF INSECT GROWTH-REGULATORS .10. SUBSTITUENT EFFECTS ON LARVICIDAL ACTIVITY OF 1-TERT-BUTYL-1-(2-CHLOROBENZOYL)-2-(SUBSTITUTED BENZOYL)HYDRAZINES AGAINST CHILO-SUPPRESSALIS AND DESIGN SYNTHESIS OF POTENT DERIVATIVES

  N OIKAWA; Y NAKAGAWA; K NISHIMURA; T UENO; T FUJITA

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Feb. 1994, Peer-reviewed

  
• Main Topic 1: Synthesis

  中川 好秋

  中川好秋、平井憲次、竹柴英雄、保原智、桑野栄一、大沢貫寿. 日本農薬学会誌,19, S275-S300, 1994, Peer-reviewed

  
• Main Topic 1: Synthesis.

  中川 好秋

  Yoshiaki Nakagawa, Kenji Hirai, Hideo Takeshiba, Satoshi Hobara, Eiichi Kuwano, and Kanjyu Osawa\tJ. Pesticide Sci.,19, S275-S300, 1994, Peer-reviewed

  
• Classical and 3-dimensional QSAR analysis of insecticidal ecdysone agonists (In Japanese).

  中川 好秋

  Yoshiaki Nakagawa. Molec. Design,16, 25-34, 1994, Peer-reviewed

  
• Quantitative structure-activity analysis of larvicidal 1-(substituted benzoyl)-2-benzoyl-1-tert-butylhydrazines against Chilo suppressalis

  N. Oikawa; Y. Nakagawa; K. Nishimura; T. Ueno; T. Fujita

  Pesticide Science, 1994, Peer-reviewed

  
• Effect of diflubenzuron on incorporation of [³H]-N-acetylglucosamine ([³H]NAGA) into chitin in the intact integument from the newly molted American cockroach Periplaneta americana

  Y. Nakagawa; F. Matsumura; Y. Hashino

  Comparative Biochemistry and Physiology. Part C: Comparative, Nov. 1993, Peer-reviewed

  
• キチン生合成に影響をおよぼす化合物の生物検定系

  中川 好秋

  Radioisotopes, Nov. 1993, Peer-reviewed

  
• Effect of diflubenzuron on the incorporation of UDP-N-acetyl-[³H]glucosamine (UDP-[³H]NAGA) to chitin in permeabilized, and isolated integuments from the newly molted American cockroach Periplaneta americana

  Y. Nakagawa; F. Matsumura

  Comparative Biochemistry and Physiology. Part C: Comparative, Nov. 1993, Peer-reviewed

  
• ENHANCEMENT OF N-ACETYLGLUCOSAMINE INCORPORATION INTO THE CULTURED INTEGUMENT OF CHILO-SUPPRESSALIS BY MOLTING HORMONE AND DIBENZOYLHYDRAZINE INSECTICIDES

  N OIKAWA; Y NAKAGAWA; Y SOYA; K NISHIMURA; N KURIHARA; T UENO; T FUJITA

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Nov. 1993, Peer-reviewed

  
• Bioassay systems for chitin synthesis modulators. (in Japanese)

  中川 好秋

  Yoshiaki Nakagawa. Radioisotopes,42, 665-666, 1993, Peer-reviewed

  
• QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-[4-(THIAZOL-2-YL)PHENYL]-PROPIONIC ACID-DERIVATIVES INHIBITING CYCLOOXYGENASE

  Y NAITO; Y YAMAURA; Y INOUE; C FUKAYA; K YOKOYAMA; Y NAKAGAWA; T FUJITA

  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, Oct. 1992, Peer-reviewed

  
• ANALYSIS AND PREDICTION OF HYDROPHOBICITY PARAMETERS OF SUBSTITUTED ACETANILIDES, BENZAMIDES AND RELATED AROMATIC-COMPOUNDS

  Y NAKAGAWA; K IZUMI; N OIKAWA; T SOTOMATSU; M SHIGEMURA; T FUJITA

  ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Jul. 1992, Peer-reviewed

  
• Quantitative structure-activity studies of benzoylphenylurea larvicides. VIII. Inhibition of N-acetylglucosamine incorporation into the cultured integument of Chilo suppressalis Walker

  Y. Nakagawa; M. Matsutani; N. Kurihara; K. Nishimura; T. Fujita

  Pesticide Biochemistry and Physiology, Jun. 1992, Peer-reviewed

  
• INHIBITION OF N-ACETYLGLUCOSAMINE INCORPORATION INTO THE CULTURED INTEGUMENT OF CHILO-SUPPRESSALIS BY DIFLUBENZURON

  Y NAKAGAWA; M MATSUTANI; N KURIHARA; K NISHIMURA; T FUJITA

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Mar. 1992, Peer-reviewed

  
• QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF LIGHT-DEPENDENT HERBICIDAL 4-PYRIDONE-3-CARBOXANILIDE DERIVATIVES .2. SUBSTITUENT EFFECTS OF ANILIDE AND PYRIDONE MOIETIES

  H OSABE; Y MORISHIMA; Y GOTO; K MASAMOTO; Y NAKAGAWA; T FUJITA

  PESTICIDE SCIENCE, 1992, Peer-reviewed

  
• QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF LIGHT-DEPENDENT HERBICIDAL 4-PYRIDONE-3-CARBOXANILIDES .1. EFFECT OF BENZENE-RING SUBSTITUENTS AT THE ANILIDE MOIETY

  H OSABE; Y MORISHIMA; Y GOTO; K MASAMOTO; Y NAKAGAWA; T FUJITA

  PESTICIDE SCIENCE, 1992, Peer-reviewed

  
• QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP OF CATECHOL DERIVATIVES INHIBITING 5-LIPOXYGENASE

  Y NAITO; M SUGIURA; Y YAMAURA; C FUKAYA; K YOKOYAMA; Y NAKAGAWA; T IKEDA; M SENDA; T FUJITA

  CHEMICAL & PHARMACEUTICAL BULLETIN, Jul. 1991, Peer-reviewed

  
• Quantitative structure-activity relationships of benzoylphenylurea larvicides. VII. Separation of effects of substituents in the multisubstituted anilide moiety on the larvicidal activity against Chilo suppressalis

  Y. Nakagawa; K. Izumi; N. Oikawa; A. Kurozumi; H. Iwamura; T. Fujita

  Pesticide Biochemistry and Physiology, May 1991, Peer-reviewed

  
• QSAR approaches in pesticide metabolism studies: An example in benzoylphenylurea larvicides.

  中川 好秋

  Toshio Fujita and Yoshiaki Nakagawa, In "Pesticide Chemistry : Advances in international research, development, and legislation," (Ed, by Helmut Frehse), VCH, Weinheim,297-304, 1991, Peer-reviewed

  
• DEVELOPMENT OF N,O-DISUBSTITUTED HYDROXYLAMINES AND N,N-DISUBSTITUTED AMINES AS INSECT JUVENILE-HORMONE MIMETICS AND THE ROLE OF THE NITROGENOUS FUNCTION FOR ACTIVITY

  A NIWA; H IWAMURA; Y NAKAGAWA; T FUJITA

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Feb. 1990, Peer-reviewed

  
• Development of N, O-disubstituted hydroxylamines and N,N-disubstituted amines as insect juvenile hormone mimetics and the role of the nitrogenous function for activity. Atsushi Niwa, Hajime Iwamura, Yoshiaki Nakagawa, and Toshio Fujita.

  中川 好秋

  J. Agric. Food Chem.,38, 514-520, 1990, Peer-reviewed

  
• DEVELOPMENT OF (4-ALKOXYPHENOXY)ALKANALDOXIME AND (4-ALKYLPHENOXY)ALKANALDOXIME O-ETHERS AS POTENT INSECT JUVENILE-HORMONE MIMICS AND THEIR STRUCTURE ACTIVITY RELATIONSHIPS

  T HAYASHI; H IWAMURA; Y NAKAGAWA; T FUJITA

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Mar. 1989, Peer-reviewed

  
• DEVELOPMENT OF (PHENOXYPHENOXY)PROPYL AND (BENZYLPHENOXY)PROPYL ETHERS AS POTENT INSECT JUVENILE-HORMONE MIMETICS

  A NIWA; H IWAMURA; Y NAKAGAWA; T FUJITA

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Mar. 1989, Peer-reviewed

  
• Quantitative structure-activity studies of benzoylphenylurea larvicides. VI. Comparison of substituent effects among activities against different insect species

  Y. Nakagawa; T. Akagi; H. Iwamura; T. Fujita

  Pesticide Biochemistry and Physiology, Feb. 1989, Peer-reviewed

  
• DEVELOPMENT OF (PHENOXYPHENOXY)ALKANALDOXIME AND (BENZYLPHENOXY)ALKANALDOXIME O-ETHERS AS POTENT INSECT JUVENILE-HORMONE MIMICS AND THEIR QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP

  A NIWA; H IWAMURA; Y NAKAGAWA; T FUJITA

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Mar. 1988, Peer-reviewed

  
• Quantitative structure-Activity studies of benzoylphenylurea larvicides. V. Substituted pyridyloxyphenyl and related derivatives

  Y. Nakagawa; T. Akagi; H. Iwamura; T. Fujita

  Pesticide Biochemistry and Physiology, Jan. 1988, Peer-reviewed

  
• Quantitative structure-activity studies of benzoylphenylurea larvicides. IV. Benzoyl Ortho substituent effects and molecular conformation

  T. Sotomatsu; Y. Nakagawa; T. Fujita

  Pesticide Biochemistry and Physiology, Feb. 1987, Peer-reviewed

  
• Quantitative structure-activity studies of benzoylphenylurea larvicides. III. Effects of substituents at the benzoyl moiety

  Y. Nakagawa; T. Sotomatsu; K. Irie; K. Kitahara; H. Iwamura; T. Fujita

  Pesticide Biochemistry and Physiology, Feb. 1987, Peer-reviewed

  
• 昆虫の脱皮を阻害する殺虫剤 中川好秋、藤田稔夫.

  中川 好秋

  化学,41, 194-195, 1986, Peer-reviewed

  
• Molting inhibitors to insects [in Japanese].

  中川 好秋

  Yoshiaki Nakagawa and Toshio Fujita. Kagaku,41, 194-195, 1986, Peer-reviewed

  
• Development of insect juvenile hormone active oxime O-ethers and carbamates. Akira Nakayama, Hajime Iwamura, Atsushi Niwa, Yoshiaki Nakagawa, and Toshio Fujita.

  中川 好秋

  J. Agric. Food Chem.,33, 1034-1041, 1985, Peer-reviewed

  
• DEVELOPMENT OF INSECT JUVENILE-HORMONE ACTIVE OXIME O-ETHERS AND CARBAMATES

  A NAKAYAMA; H IWAMURA; A NIWA; Y NAKAGAWA; T FUJITA

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1985, Peer-reviewed

  
• EFFECTS OF INSECT GROWTH REGULATORY BENZIMIDAZOLE DERIVATIVES ON CULTURED INTEGUMENT OF THE RICE STEM BORER AND MITOCHONDRIA FROM RAT-LIVER

  Y NAKAGAWA; E KUWANO; M ETO; T FUJITA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, Peer-reviewed

  
• Quantitative structure-activity studies of benzoylphenylurea larvicides. II. Effect of benzyloxy substituents at aniline moiety against Chilo suppressalis Walker

  Y. Nakagawa; H. Iwamura; T. Fujita

  Pesticide Biochemistry and Physiology, 1985, Peer-reviewed

  
• Quantitative structure-activity studies of benzoylphenylurea larvicides. I. Effect of substituents at aniline moiety against Chilo suppressalis walker

  Y. Nakagawa; K. Kitahara; T. Nishioka; H. Iwamura; T. Fujita

  Pesticide Biochemistry and Physiology, 1984, Peer-reviewed

  
• Cultured integument of Chilo suppressalis as a bioassay system of insect growth regulators. Katsuhiko Kitahara, Yoshiaki Nakagawa, Takaaki Nishioka, and Toshio Fujita.

  中川 好秋

  Agric. Biol. Chem.,47, 1583-1589, 1983, Peer-reviewed

  
• CULTURED INTEGUMENT OF CHILO-SUPPRESSALIS AS A BIOASSAY SYSTEM OF INSECT GROWTH-REGULATORS

  K KITAHARA; Y NAKAGAWA; T NISHIOKA; T FUJITA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1983, Peer-reviewed

  
• Biosynthesis of parinaric acid (9,11,13,15-octadecatetraenoic acid) Manjiro Noda, Kumiko Ohga, Yoshiaki Nakagawa and Ken-ichi Ichihara.

  中川 好秋

  Dev. Plant Biol.,6, 215-218, 1980, Peer-reviewed

  
• Genome-wide identification of tebufenozide resistance genes in the smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae)

  NAKAGAWA Yoshiaki

  Scientific Report, Peer-reviewed

  

Misc.

• Native Chemical Ligation法によるサソリ毒素ペプチドLaIT1の効率的合成

  中川好秋

  日本農芸化学会関西支部大会第466回講演会, 2010, Peer-reviewed

  
• ヤエヤマサソリ毒液由来殺虫性ペプチドLaIT1の構造と活性

  中川好秋

  第25回農薬デザイン研究会, 2010, Peer-reviewed

  
• 昆虫脱皮ホルモン受容体とリガンドとの相互作用

  中川好秋

  第38回構造活性相関シンポジウム, 2010, Peer-reviewed

  
• ヤエヤマサソリ毒液由来の殺虫性ペプチドLaIT1の構造活性相関

  中川好秋

  日本農芸化学会2010年度大会, 2010, Peer-reviewed

  
• マダラサソリ毒液に含まれる殺虫性ペプチド Im-3 の単離と同定

  中川好秋

  日本農薬学会第35回大会, 2010, Peer-reviewed

  
• Native Chemical Ligation 法を用いた殺虫性ペプチド LaIT1 の効率的合成

  中川好秋

  日本農薬学会第35回大会, 2010, Peer-reviewed

  
• 昆虫脱皮ホルモン受容体リガンドの分子設計

  中川好秋

  日本農薬学会第35回大会, 2010, Peer-reviewed

  
• Characterization of insect toxins isolated from the venom of the scorpion Liocheles australasiae

  Yoshiaki Nakagawa

  12th IUPAC International Congress of Pesticide Chemitry, 2010, Peer-reviewed

  
• Virtual Screening for Novel Ligands of Molting Hormonal Receptor

  Yoshiaki Nakagawa

  12th IUPAC International Congress of Pesticide Chemitry, 2010, Peer-reviewed

  
• Comparison of the activity of various ecdysone agonists evaluated against intact insect cells and in vitro translated EcR/USP proteins

  Yoshiaki Nakagawa

  12th IUPAC International Congress of Pesticide Chemitry, 2010, Peer-reviewed

  
• Virtual screening for the ligands of molting hormonal receptor

  HARADA Toshiyuki; NAKAGAWA Yoshiaki; YAMADA Yutaka; OHE Takehiro; MIYAGAWA Hisashi

  構造活性相関シンポジウム講演要旨集, 05 Nov. 2009, Peer-reviewed

  
• マダラサソリ毒液に含まれる殺虫性ペプチドの単離・同定 (第2報)

  中川好秋

  日本農芸化学会2010年度大会, 2009, Peer-reviewed

  
• ヤエヤマサソリにおける脱皮ホルモンの探索

  中川好秋

  日本農芸化学会2009年度大会, 2009, Peer-reviewed

  
• マダラサソリ(Isometrus maculatus)より単離したペプチド毒素Im-1の昆虫毒性ならびに抗菌活性の評価

  中川好秋

  日本農芸化学会関西支部第462回講演会, 2009, Peer-reviewed

  
• サソリ毒液由来殺虫性ペプチド LaIT1 の昆虫中枢神経系に対する作用

  中川好秋

  日本農薬学会第34回大会, 2009, Peer-reviewed

  
• ヤエヤマサソリ毒液に含まれる殺虫性ペプチド毒素 LaIT2の単離と同定

  中川好秋

  日本農薬学会第34回大会, 2009, Peer-reviewed

  
• マダラサソリ毒液に含まれる殺虫性ペプチドIm-2の構造決定

  中川好秋

  日本農薬学会第34回大会, 2009, Peer-reviewed

  
• In silico screening for the ligand of molting hormonal receptor

  Yoshiaki Nakagawa

  1st China-Japan-Korea Workshop on Pesticide Science, 2009, Peer-reviewed

  
• A203 テトラヒドロキノリン類縁体の合成および脱皮ホルモン受容体との結合親和性測定

  中川好秋

  講演要旨集, 11 Mar. 2008, Peer-reviewed

  
• マダラサソリ毒液に含まれる殺虫性ペプチドの単離・同定

  坂井暖; 花井陽介; 宮下正弘; 中川好秋; 宮川恒

  日本農芸化学会大会講演要旨集, 05 Mar. 2008, Peer-reviewed

  
• マダラサソリ毒液に含まれる殺虫性ペプチドの単離・同定

  中川好秋

  日本農薬学会第33回大会, 2008, Peer-reviewed

  
• バーチャルスクリーニングを用いた新規脱皮ホルモンアゴニストの探索

  中川好秋

  第23回農薬デザイン研究会, 2008, Peer-reviewed

  
• 薬物排出に関わるP-糖タンパク質の基質認識機構－さまざまな農薬の構造とATPase活性との関係－

  中川好秋

  日本農薬学会第33回大会, 2008, Peer-reviewed

  
• ネッタイシマカ脱皮ホルモン受容体を用いたエクダイソンアゴニストのスクリーニング

  中川好秋

  日本農薬学会第33回大会, 2008, Peer-reviewed

  
• Virtual screening and structural development for insect molting hormonal agonists

  Yoshiaki Nakagawa

  第36回構造活性相関シンポジウム, 2008, Peer-reviewed

  
• Measurement of receptor-binding activity of non-steroidal ecdysone agonists using in vitro expressed receptor proteins (EcR/USP complex) of Chilo suppressalis and Drosophila melanogaster

  C Minakuchi; Y Nakagawa; M Kamimura; H Miyagawa

  NEW DISCOVERIES IN AGROCHEMICALS, 2005, Peer-reviewed

  

Presentations

• Calculation of ligand-receptor binding energy of brassinosteroids and molecular design of brassinnosteroid-like compounds

  NAKAGAWA Yoshiaki

  日本農芸化学会2019年度大会, 24 Mar. 2019

  
• Synthesis and biological evaluation of the antimicrobial peptide LaCT1 from the venom of the scorpion Liocheles australasiae

  OKABE Ryota

  The 44th Annual meeting of PSSJ, 12 Mar. 2019

  
• Structure development of tetrahydroquinoline-typ ecdysone agonists

  UENO Minori

  44th Annual meeting of PSSJ, 12 Mar. 2019

  
• 脱皮の分子メカニズムとその阻害剤の構造活性相関

  農薬バイオフロンティアシンポジウム, 2010

  
• Nuclear receptors in caterpillars and aphids: towards selective targets for pest control

  12th IUPAC International Congress of Pesticide Chemitry, 2010

  

Books and Other Publications

• 新版 農薬の科学

  中川 好秋, Joint work, 脱皮・変態を攪乱する薬剤

  朝倉書店, Feb. 2019, Not refereed

  
• 農薬の創製研究の動向

  中川好秋; 赤松美紀, Joint work, 第14章 農薬の構造活性相関研究ー新規農薬の創製を目指して

  シーエムシー出版, 2018, Not refereed

  
• Non-First Order Degradation and Time-Dependent Sorption of Organic Chemicals in Soil

  Aleksandar Sabljic; Yoshiaki Nakagawa, Contributor, Sorption and Quantitative Structure-Activity Relationship (QSAR)

  American Chemical Society, 2014, Not refereed

  
• Advanced screening to identify novel pesticides, In "Advanced Technologies for Managing Insect Pests

  Nakagawa Y; Harada T

  Springer, 2012, Not refereed

  
• 昆虫成長制御剤概論，「脱皮と変態の生物学」

  中川好秋

  東海大学出版会, 2011, Not refereed

  
• エクジステロイド受容体の構造と機能，「脱皮と変態の生物学」

  中川好秋

  東海大学出版会, 2011, Not refereed

  
• 『分子昆虫学』書評

  中川好秋

  日本農薬学会誌 35巻，213, 2010, Not refereed

  
• SAR and QSAR Analyses of Substituted Dibenzoylhydrazines for Their Mode of Action as Ecdysone Agonists

  Fujita T; Nakagawa Y

  In: Endocrine Disruption Modeling”, (Ed. J. Devillers), pp. 357-377, CRC Press, Taylor & Francis Group LLC,, 2009, Not refereed

  
• SAR and QSAR studies for in vivo and in vitro activities of ecdysone agonists.

  Nakagawa Y; Hormann R; Smagghe G

  In: Ecdysones: Structures and Functions (ed. G. Smagghe), pp. 475-509, Springer,, 2009, Not refereed

  
• 日本に生息するサソリの持つ毒素の研究．昆虫科学が拓く未来

  宮下正弘; 中川好秋

  京都大学学術出版会, 2009, Not refereed

  
• 昆虫脱皮の分子メカニズムー新たな害虫防除手法を探るー，昆虫科学が拓く未来．

  中川好秋

  京都大学学術出版会, 2009, Not refereed

  
• 昆虫脱皮の分子メカニズムー新たな害虫防除手法を探るー

  中川好秋

  昆虫科学が拓く未来（藤崎憲二，西田律夫，佐久間正幸編），京都大学学術出版会，pp.271-298,, 2009, Not refereed

  
• 日本に生息するサソリの持つ毒素の研究

  宮下正弘; 中川好秋

  昆虫科学が拓く未来（藤崎憲二，西田律夫，佐久間正幸編），京都大学学術出版会，pp.304-306,, 2009, Not refereed

  
• 新しい殺虫剤

  中川好秋; 宮川恒

  植物を守る 21世紀の農学第３巻（佐久間正幸編），京都大学学術出版会，pp.304-306,, 2008, Not refereed

  
• 脱皮ホルモン類縁体，ホルモンハンドブック新訂e-Book版，

  中川好秋

  南江堂，, 2007, Not refereed

  
• 脱皮ホルモン

  中川 好秋

  朝倉書店「農芸化学の事典」,/ , 168-171, 2003, Not refereed

  
• 成育制御剤

  中川 好秋

  ソフトサイエンス社「次世代の農薬開発」,/ , 119-113, 2003, Not refereed

  

Industrial Property Rights

• 特願PCT/JP2018, 「植物ステロイドホルモン（ブラシノライド）様活性をもつ非ステロイド化合物の創製」

  中川好秋; 杉浦愛理; 瀧本征佑; 幌岩真理; 宮川恒; 松尾美登理

  

Awards

• 1996

  日本農薬学会奨励賞
• 1996

  日本農薬学会奨励賞受賞
• 2007

  日本農薬学会業績賞受賞
• 11 Mar. 2019

  Pesticide Science Society of Japan, Best Paper Award 2019

External funds: Kakenhi

• Drug discovery against retinal degenerative diseases based on the functional regulation of myofibroblasts.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48040:Medical biochemistry-related

  Yamaguchi University;Osaka University

  Kenichiro Hayashi

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  加齢黄斑変性;網膜色素上皮細胞;筋線維芽細胞;瘢痕;血管新生;血管内皮細胞;Benzoylphenyl urea (BPU);CRP2;網膜変性疾患;Benzoylphenyl urea;瘢痕形成;創薬研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07351/
• Molecular design of non-steroidal ecdysone-like compounds

  Grant-in-Aid for Scientific Research (C)

  Basic Section 39040:Plant protection science-related

  Kyoto University

  Yoshiaki Nakagawa

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  ecdysone;ecdysone receptor;dibenzoylhydrazine;in silico screening;receptor binding;molting hormone;ponasterone;20-hydroxyecdysone;brassinosteroid;sf9;steroid;virtual screening;dacryhainansterone;ajugasterone;ponasterone A;steroids;pharmacophore;Ecdysone;In silico;EcR;Ponasterone;Insect cell

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06051/
• Molting analysis based on the view of cell biology: mode of action of molting inhibitors and its application

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Ken'ichiro Hayashi

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  benzoyl phenyl urea;筋線維芽細胞;線維化症;ガン浸潤転移;網膜変性疾患;benzoylphenylurea;細胞運動;benzoyl phenylurea;ガン関連線維芽細胞 (CAF);がン逡巡;0-NBD;ATIC;昆虫表皮真皮細胞;ガン関連線維芽細胞(CAF);扁平上皮ガン;ガン細胞浸潤;昆虫表皮真皮細胞初代培養;細胞・組織;昆虫;有機化学;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08142/
• Development of molecular design basis for molting hormone receptor regulation

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Yoshiaki Nakagawa

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  ecdysone;molting hormone;MM/PBSA;分子動力学;結合自由エネルギー;インシリコスクリーニング;エクダイソン;ecdysone receptor;脱皮ホルモン;ジアシルヒドラジン;MM/PBSA法;インシリコスクリーング;脱皮ホルモン受容体;in silicoスクリーニング;ドッキングシミュレーション;MM-PBSA;受容体タンパク質;Ecdysone;Molting;Insect growth disruptor;Drug design;In silico screenig

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07625/
• Dry and wet approach for the disclosure of the interaction between ecdysone receptor and ligand molecule

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Yoshiaki NAKAGAWA

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  ecdysoone;ponasterone A;ecdysone receptor;diacylhydrazine;20-hydroxyecdysone;imidazole;tetrahydroquinoline;Bemisia tabaci;脱皮ホルモン;ecdysone;Ponasterone;タバココナジラミ;imidazothiadiazole;EcR;molting hormone;receptor binding;Sf-9 cell;Lepidoptera;Diptera;ponasterone;ecdysteroid;insect growth regulator;binding affinity

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25450070/
• Investigation of cell function from the point of view of the regulatory mechanism for cellular localization of myocardin family members

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Ken'ichiro HAYASHI

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  myocardin;MRTF-A/B;Crm1;importin α/β1;CCG-1423;核移行;核外移行;上皮間葉転換;細胞内局在制御;thymosinβ4;Arp5;SRF;平滑筋細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590332/
• Physiological study of adaptation to ultraviolet radiation in spider mites

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Masahiro OSAKABE

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  昆虫生理;光生物学;光回復;紫外線損傷;UVB;可視光;UVA;ダニ類;紫外線;アスタキサンチン;スカベンジャー;休眠誘起;カロテノイド;休眠色;UV-B;ミカンハダニ;カンザワハダニ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22380036/
• Ligand recognition mechanism of the ecdysone hormone receptor for the molecular design of a new pesticide

  Grant-in-Aid for Scientific Research (C)

  Osaka Prefecture University

  Toshiji TADA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  蛋白質結晶学;構造生物化学;分子認識;昆虫;構造活性相関;蛋白質;分析科学;生体機能利用;環境対応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21603011/
• 脱皮ホルモン様活性発現に必須の化学構造およびその物理化学的性質の解明

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  中川 好秋

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  脱皮ホルモン;鱗翅目昆虫;鞘翅目昆虫;殺虫活性;ポナステン;ジベンゾイルヒドラジン;受容体結合活性;疎水性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10161207/
• Design of nonsteroidal durassinosteroids

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Yoshiaki NAKAGAWA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  ブラシノステロイド;ブラシノライド;カスタステロン;エピブラシノライド;ホモブラシノライド;イネ葉身屈曲試験法;ステロイドホルモン;オキシム系化合物;脱皮ホルモン, brassinolide;brassinosteroids;castasterone;epibrassinolide;homobrassinolide;rice lamina inclination test;ecdysones;oxime compounds

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09660117/
• Elucidation of the chemical structure necessary to the molting hormonal activity and the prediction of the hormone-receptor binding mode

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Yoshiaki NAKAGAWA

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  dibenzoylhydrazine;ecdysone;脱皮ホルモン;定量的構造活性相関;ニカメイチュウ;ステロイド;CoMFA;培養表皮;エクダイソン;培養表皮系;殺虫活性;CoMFA法, dibenzoylhydrazine;ecdysone;molting hormone;quantitative structure activity relationship;rice stem borer;steroid;CoMFA;coltured integument

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07660135/
• Molecular Mechanism of Target Recognition by Insect Growth Regulators

  Grant-in-Aid for General Scientific Research (B)

  Kyoto University

  Toshio FUJITA

  From 01 Apr. 1985, To 31 Mar. 1987, Project Closed

  昆虫幼若ホルモン;構造活性相関;ピレスロイド;ベンゾイルアミノチアジアゾール;ベンゾイルフェニルウレア, Insect juvenile hormone;Quantitative structure-activity relationship;Pyrethroids;Benzoylphenylureas

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60470136/

External funds: others

• Structure-activity relationship of insect molting hormones
• Structure-activity relationship of steroidal plant hormone, brassinosteroids
• Mode of action study of chitin synthesis inhibitors
• Identification and structural determination of insecticidal peptides from scorpion venom

Education

Teaching subject(s)

• From Apr. 2011, To Mar. 2012

  有機反応機構論II

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  有機化学実験

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  生物有機化学I

  Spring, 農学部
• From Apr. 2011, To Mar. 2012

  Strategy of Modern Agriculture Sciences for the harmony of

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  生物調節化学専攻実験

  農学研究科
• From Apr. 2011, To Mar. 2012

  生物調節化学専攻演習

  農学研究科
• From Apr. 2012, To Mar. 2013

  Exercises in Information Processing Basic

  Fall, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Organic Reaction Mechanism II

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2012, To Mar. 2013

  Strategy of Modern Agriculture Sciences for the harmony of crop production with environment

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Organic Reaction Mechanism II

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2013, To Mar. 2014

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2013, To Mar. 2014

  Bioregulation Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Course of Bioregulation Chemistry

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Strategy of Modern Agriculture Sciences for the harmony of crop production with environment

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Organic Reaction Mechanism II

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2014, To Mar. 2015

  Bioregulation Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course of Bioregulation Chemistry

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Strategy of Modern Agriculture Sciences for the harmony of crop production with environment

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Organic Reaction Mechanism II

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2015, To Mar. 2016

  Experimental Course of Bioregulation Chemistry1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course of Bioregulation Chemistry

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Bioregulation Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Bioregulation Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2015, To Mar. 2016

  Strategy of Modern Agriculture Sciences for the harmony of crop production with environment

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Applied Life Sciences II

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Organic Reaction Mechanism I

  Spring, 農学部
• From Apr. 2016, To Mar. 2017

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2016, To Mar. 2017

  Experimental Course of Bioregulation Chemistry1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Bioregulation Chemistry2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Bioregulation Chemistry

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Bioregulation Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Bioregulation Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Bioregulation Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2017, To Mar. 2018

  Pesticide Chemistry

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Applied Life Sciences II

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Organic Reaction Mechanism I

  Spring, 農学部
• From Apr. 2017, To Mar. 2018

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2017, To Mar. 2018

  Experimental Course of Bioregulation Chemistry1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Bioregulation Chemistry2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Bioregulation Chemistry

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Bioregulation Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Bioregulation Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Bioregulation Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2018, To Mar. 2019

  Pesticide Chemistry

  Fall, 農学研究科
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences II

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences II

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Organic Reaction Mechanism I

  Spring, 農学部
• From Apr. 2018, To Mar. 2019

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2018, To Mar. 2019

  Experimental Course of Bioregulation Chemistry1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Bioregulation Chemistry2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Bioregulation Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Bioregulation Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2019, To Mar. 2020

  Pesticide Chemistry

  Fall, 農学研究科
• From Apr. 2019, To Mar. 2020

  Applied Life Sciences II

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Organic Chemistry

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Organic Reaction Mechanism I

  Spring, 農学部
• From Apr. 2019, To Mar. 2020

  Bioorganic Chemistry I

  Spring, 農学部
• From Apr. 2019, To Mar. 2020

  Experimental Course of Bioregulation Chemistry1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course of Bioregulation Chemistry2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Bioregulation Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Bioregulation Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Chemistry of Bioregulation

  Fall, 農学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Organic Chemistry

  Year-long, 農学部
• From Apr. 2020, To Mar. 2021

  Organic Reaction Mechanism I

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Experimental Course of Bioregulation Chemistry1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course of Bioregulation Chemistry2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Bioregulation Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Bioregulation Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Chemistry of Bioregulation

  Fall, 農学研究科

Part-time lecturer

• From 2008, To 2008

  後期, 京都府立大学
• From 2009, To 2009

  後期, 京都府立大学
• From 2010, To 2010

  後期, 京都府立大学
• From 2010, To 2010

  集中講義, 甲南大学

Administration

School management (title, position)

• From 01 Apr. 2013, To 31 Mar. 2015

  北部構内実験排水系管理委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  北部構内実験排水系管理委員会 委員
• From 01 Apr. 2016

  化学物質専門委員会　委員会
• From 01 Oct. 2018, To 31 Mar. 2020

  放射性同位元素総合センター共同利用検討委員会
• From 01 Apr. 2020, To 31 Mar. 2021

  放射性同位元素総合センター共同利用検討委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  環境安全保健機構化学物質専門小委員会

Faculty management (title, position)

• From 01 Apr. 2015, To 31 Mar. 2021

  男女共同参画推進委員会　委員
• From 11 May 2010, To 31 Mar. 2017

  放射線障害防止委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2021

  環境・安全・衛生委員会　委員

Academic, Social Contribution

Committee Memberships

• 常任幹事, 日本薬学会構造活性相関部会
• 編集委員, 日本農薬学会