Basic Information

Email Address

• Email Address

  takeda.hiroaki.6jkyoto-u.ac.jp

Professional Memberships

• From Jun. 2024, To Present

  日本糖質学会
• From Mar. 2024, To Present

  日本脂質生化学会
• From Oct. 2020, To Present

  Japan Society for SFC
• From Apr. 2015, To Mar. 2019

  日本質量分析学会

Academic Degree

• 25 Mar. 2015

  修士(工学) (大阪大学)
• 20 Mar. 2018

  博士(理学) (九州大学)

Academic Resume (Graduate Schools)

• 九州大学, 大学院システム生命科学府, システム生命科学専攻, 修了
• 大阪大学, 大学院工学研究科, 生命先端工学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 大阪大学, 工学部応用自然科学科, 卒業

High School

• High School

  洛南高等学校

Research History

• From Apr. 2026, To Present

  Kyoto University, Multi-Omics Platform, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Program-Specific Researcher
• From Mar. 2025, To Mar. 2026

  National Institute of Advanced Industrial Science and Technology (AIST), Bioanalytical Research Group, Biomedical Research Institute, Department of Life Science and Biotechnology, Researcher
• From Apr. 2022, To Mar. 2025

  Tokyo University of Agriculture and Technology, Institute of Engineering Division of Biotechnology and Life Science, Department of Systems Biology, 産学官連携研究員
• From Jul. 2020, To Mar. 2025

  Kyushu University, Medical Institute of Bioregulation, Division of Metabolomics, 共同研究員
• From Apr. 2022, To Mar. 2024

  RIKEN, Center for Brain Science, Laboratory for Neural Cell Dynamics, 客員研究員
• From May 2019, To Mar. 2022

  RIKEN, Center for Brain Science, Laboratory for Neural Cell Dynamics, 研究員
• From Apr. 2018, To Apr. 2019

  Kyushu University, Medical Institute of Bioregulation, Division of Metabolomics, 学術研究員

ID,URL

• ORCID ID

  0000-0002-9299-4748

• J-Global ID

  201901008122531399

• External link

  https://kdb.iimc.kyoto-u.ac.jp/profile_private/ja.2fe81fd0153e733b.html

researchmap URL

• https://researchmap.jp/19900914

Research

Research Interests

• Lipidomics
• Glycolipid
• Phospholipid
• Chromatography
• Supercritical fluid
• Mass spectrometry
• Structural analysis
• Quantitative omics
• Atherosclerosis

Research Areas

• Life sciences, Pharmaceuticals - analytical and physicochemistry, 生物物理、構造解析、計算科学、情報科学
• Nanotechnology/Materials, Molecular biochemistry, Metabolome Analysis
• Life sciences, Biophysics, Systems Biology
• Life sciences, Systems genomics, Bioinformatics

Papers

• Sodium ion-assisted structural lipidomics for sphingolipid profiling

  Hiroaki Takeda; Daiki Asakawa; Manami Takeuchi; Hiroshi Tsugawa

  bioRxiv, 05 Feb. 2026, Lead author, Corresponding author

  
• Characterizing lipoprotein profiles in coronary atherosclerosis development through quantitative lipidomics and proteomics approaches

  Hiroaki Takeda; Yoshihiro Izumi; Yui Koike; Tomonari Koike; Kohta Nakatani; Kosuke Hata; Masaki Matsumoto; Masashi Shiomi; Takeshi Bamba

  npj Cardiovascular Health, 30 Oct. 2025, Peer-reviewed, Lead author

  
• Dual fragmentation via collision-induced and oxygen attachment dissociations using water and its radicals for C=C position-resolved lipidomics

  Hiroaki Takeda; Mami Okamoto; Hidenori Takahashi; Bujinlkham Buyantogtokh; Noriyuki Kishi; Hideyuki Okano; Hiroyuki Kamiguchi; Hiroshi Tsugawa

  Communications Chemistry, 13 May 2025, Peer-reviewed, Lead author, Corresponding author

  
• Data-Independent Acquisition Coupled with Electron-Activated Dissociation for In-Depth Structure Elucidation of the Fatty Acid Ester of Hydroxy Fatty Acids

  Yuto Kurizaki; Yuki Matsuzawa; Mikiko Takahashi; Hiroaki Takeda; Mayu Hasegawa; Makoto Arita; Junki Miyamoto; Hiroshi Tsugawa

  Analytical Chemistry, 04 Apr. 2025, Peer-reviewed

  
• MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

  Hiroaki Takeda; Yuki Matsuzawa; Manami Takeuchi; Mikiko Takahashi; Kozo Nishida; Takeshi Harayama; Yoshimasa Todoroki; Kuniyoshi Shimizu; Nami Sakamoto; Takaki Oka; Masashi Maekawa; Mi Hwa Chung; Yuto Kurizaki; Saki Kiuchi; Kanako Tokiyoshi; Bujinlkham Buyantogtokh; Misaki Kurata; Aleš Kvasnička; Ushio Takeda; Haruki Uchino; Mayu Hasegawa; Junki Miyamoto; Kana Tanabe; Shigenori Takeda; Tetsuya Mori; Ryota Kumakubo; Tsuyoshi Tanaka; Tomoko Yoshino; Mami Okamoto; Hidenori Takahashi; Makoto Arita; Hiroshi Tsugawa

  Nature Communications, 28 Nov. 2024, Peer-reviewed, Lead author

  
• A Procedure for Solid-Phase Extractions Using Metal-Oxide-Coated Silica Column in Lipidomics

  Hiroaki Takeda; Manami Takeuchi; Mayu Hasegawa; Junki Miyamoto; Hiroshi Tsugawa

  Analytical Chemistry, 16 Oct. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Using Data-Dependent and -Independent Hybrid Acquisitions for Fast Liquid Chromatography-Based Untargeted Lipidomics

  Kanako Tokiyoshi; Yuki Matsuzawa; Mikiko Takahashi; Hiroaki Takeda; Mayu Hasegawa; Junki Miyamoto; Hiroshi Tsugawa

  Analytical Chemistry, 11 Jan. 2024, Peer-reviewed

  
• Protecting-group-free glycosylation of phosphatidic acid in aqueous media.

  Koki Kano; Nozomi Ishii; Atsushi Miyagawa; Hiroaki Takeda; Yoshio Hirabayashi; Hiroyuki Kamiguchi; Peter Greimel; Ichiro Matsuo

  Organic & Biomolecular Chemistry, 09 Feb. 2023, Peer-reviewed

  
• Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.

  Takeshi Yamamoto; Yoshitsugu Takabatake; Satoshi Minami; Shinsuke Sakai; Ryuta Fujimura; Atsushi Takahashi; Tomoko Namba-Hamano; Jun Matsuda; Tomonori Kimura; Isao Matsui; Jun-Ya Kaimori; Hiroaki Takeda; Masatomo Takahashi; Yoshihiro Izumi; Takeshi Bamba; Taiji Matsusaka; Fumio Niimura; Motoko Yanagita; Yoshitaka Isaka

  Autophagy, 16 Jun. 2020, Peer-reviewed

  
• Lipidomic Analysis of Cells and Extracellular Vesicles from High- and Low-Metastatic Triple-Negative Breast Cancer.

  Nao Nishida-Aoki; Yoshihiro Izumi; Hiroaki Takeda; Masatomo Takahashi; Takahiro Ochiya; Takeshi Bamba

  Metabolites, 13 Feb. 2020, Peer-reviewed

  
• Lipid Profiling of Serum and Lipoprotein Fractions in Response to Pitavastatin Using an Animal Model of Familial Hypercholesterolemia

  Hiroaki Takeda; Yoshihiro Izumi; Shohei Tamura; Tomonari Koike; Yui Koike; Masashi Shiomi; Takeshi Bamba

  Journal of Proteome Research, 22 Jan. 2020, Peer-reviewed, Lead author

  
• Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector

  Hiroaki Takeda; Masatomo Takahashi; Takeshi Hara; Yoshihiro Izumi; Takeshi Bamba

  Journal of Lipid Research, Aug. 2019, Peer-reviewed, Lead author

  
• Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi; Hiroaki Takeda; Yasuhiro Irino; Norie Kimura; Satoshi Yamada; Nobue Kuniyoshi; Akio Kikumori; Yu Koike; Tomonari Koike; Masaru Yoshida; Yoshihiro Izumi; Masakazu Shinohara; Takeshi Bamba; Tatsuro Ishida

  Atherosclerosis, May 2019, Peer-reviewed

  
• Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry

  Hiroaki Takeda; Yoshihiro Izumi; Masatomo Takahashi; Thanai Paxton; Shohei Tamura; Tomonari Koike; Ying Yu; Noriko Kato; Katsutoshi Nagase; Masashi Shiomi; Takeshi Bamba

  Journal of Lipid Research, Jul. 2018, Peer-reviewed, Lead author

  
• Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice

  Masuko Kobori; Yumiko Takahashi; Hiroaki Takeda; Masatomo Takahashi; Yoshihiro Izumi; Yukari Akimoto; Mutsumi Sakurai; Hideaki Oike; Toshiyuki Nakagawa; Masanori Itoh; Takeshi Bamba; Toshiyuki Kimura

  Scientific Reports, 13 Jun. 2018, Peer-reviewed

  
• Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release

  Yoshinari Obata; Shunbun Kita; Yoshihisa Koyama; Shiro Fukuda; Hiroaki Takeda; Masatomo Takahashi; Yuya Fujishima; Hirofumi Nagao; Shigeki Masuda; Yoshimitsu Tanaka; Yuto Nakamura; Hitoshi Nishizawa; Tohru Funahashi; Barbara Ranscht; Yoshihiro Izumi; Takeshi Bamba; Eiichiro Fukusaki; Rikinari Hanayama; Shoichi Shimada; Norikazu Maeda; Iichiro Shimomura

  JCI Insight, 19 Apr. 2018, Peer-reviewed

  
• Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)

  Shohei Tamura; Yui Koike; Hiroaki Takeda; Tomonari Koike; Yoshihiro Izumi; Ryosuke Nagasaka; Tetsuto Tsunoda; Motoo Tori; Kazuo Ogawa; Takeshi Bamba; Masashi Shiomi

  European Journal of Pharmacology, 05 Mar. 2018, Peer-reviewed

  
• Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950–Metabolites in Frozen Human Plasma

  John A. Bowden; Alan Heckert; Candice Z. Ulmer; Christina M. Jones; Jeremy P. Koelmel; Laila Abdullah; Linda Ahonen; Yazen Alnouti; Aaron M. Armando; John M. Asara; Takeshi Bamba; John R. Barr; Jonas Bergquist; Christoph H. Borchers; Joost Brandsma; Susanne B. Breitkopf; Tomas Cajka; Amaury Cazenave-Gassiot; Antonio Checa; Michelle A. Cinel; Romain A. Colas; Serge Cremers; Edward A. Dennis; James E. Evans; Alexander Fauland; Oliver Fiehn; Michael S. Gardner; Timothy J. Garrett; Katherine H. Gotlinger; Jun Han; Yingying Huang; Aveline Huipeng Neo; Tuulia Hyötyläinen; Yoshihiro Izumi; Hongfeng Jiang; Houli Jiang; Jiang Jiang; Maureen Kachman; Reiko Kiyonami; Kristaps Klavins; Christian Klose; Harald C. Köfeler; Johan Kolmert; Therese Koal; Grielof Koster; Zsuzsanna Kuklenyik; Irwin J. Kurland; Michael Leadley; Karen Lin; Krishna Rao Maddipati; Danielle McDougall; Peter J. Meikle; Natalie A. Mellett; Cian Monnin; M. Arthur Moseley; Renu Nandakumar; Matej Oresic; Rainey Patterson; David Peake; Jason S. Pierce; Martin Post; Anthony D. Postle; Rebecca Pugh; Yunping Qiu; Oswald Quehenberger; Parsram Ramrup; Jon Rees; Barbara Rembiesa; Denis Reynaud; Mary R. Roth; Susanne Sales; Kai Schuhmann; Michal Laniado Schwartzman; Charles N. Serhan; Andrej Shevchenko; Stephen E. Somerville; Lisa St. John-Williams; Michal A. Surma; Hiroaki Takeda; Rhishikesh Thakare; J. Will Thompson; Federico Torta; Alexander Triebl; Martin Trötzmüller; S. J. Kumari Ubhayasekera; Dajana Vuckovic; Jacquelyn M. Weir; Ruth Welti; Markus R. Wenk; Craig E. Wheelock; Libin Yao; Min Yuan; Xueqing Heather Zhao; Senlin Zhou

  Journal of Lipid Research, Dec. 2017, Peer-reviewed

  
• Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation

  Satoshi Minami; Takeshi Yamamoto; Yoshitsugu Takabatake; Atsushi Takahashi; Tomoko Namba; Jun Matsuda; Tomonori Kimura; Jun-ya Kaimori; Isao Matsui; Takayuki Hamano; Hiroaki Takeda; Masatomo Takahashi; Yoshihiro Izumi; Takeshi Bamba; Taiji Matsusaka; Fumio Niimura; Yoshitaka Isaka

  Autophagy, 08 Sep. 2017, Peer-reviewed

  
• Lipoprotein Profiling Methodology Based on Determination of Apolipoprotein Concentration

  Hiroaki Takeda; Yoshihiro Izumi; Atsumi Tomita; Tomonari Koike; Masashi Shiomi; Eiichiro Fukusaki; Fumio Matsuda; Takeshi Bamba

  Bioanalysis, 06 Dec. 2016, Peer-reviewed, Lead author

  
• Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits

  Hiroaki Takeda; Tomonari Koike; Yoshihiro Izumi; Takayuki Yamada; Masaru Yoshida; Masashi Shiomi; Eiichiro Fukusaki; Takeshi Bamba

  Journal of Bioscience and Bioengineering, Oct. 2015, Peer-reviewed, Lead author

  

Misc.

• 脳特異的な新規アシル化糖脂質の責任細胞と生合成経路の解析

  清水邦善; 竹田浩章; 坂本七海; 原山武士; 津川裕司

  日本生化学会大会プログラム・講演要旨集, Nov. 2025

  
• 生命現象理解へ向けたリピドミクス技術開発

  時吉花菜子; 竹内愛美; 竹田浩章; 津川裕司

  生物物理, Oct. 2025, Peer-reviewed

  
• Characterizing lipoprotein profiles in coronary atherosclerosis development through quantitative lipidomics and proteomics approaches

  Hiroaki Takeda; Yoshihiro Izumi; Yui Koike; Tomonari Koike; Kohta Nakatani; Kosuke Hata; Masaki Matsumoto; Masashi Shiomi; Takeshi Bamba

  bioRxiv, 18 Mar. 2025, Lead author

  
• Data-independent acquisition coupled with electron-activated dissociation for in-depth structure elucidation of fatty acid ester of hydroxy fatty acids

  Yuto Kurizaki; Yuki Matsuzawa; Mikiko Takahashi; Hiroaki Takeda; Mayu Hasegawa; Makoto Arita; Junki Miyamoto; Hiroshi Tsugawa

  bioRxiv, 13 Dec. 2024

  
• Dual fragmentation via collision-induced and oxygen attachment dissociations using water and its radicals for C=C position-resolved lipidomics

  Hiroaki Takeda; Mami Okamoto; Hidenori Takahashi; Bujinlkham Buyantogtokh; Noriyuki Kishi; Hideyuki Okano; Hiroyuki Kamiguchi; Hiroshi Tsugawa

  bioRxiv, 03 Nov. 2024, Lead author, Corresponding author

  
• 【脂質多様性の生物学と疾患制御】脂質多様性の解明や定量化を可能にする最先端リピドミクス技術

  竹田浩章; 和泉自泰; 馬場健史

  医学のあゆみ, Jun. 2024

  
• 脂質多様性の解明に向けた高深度リピドミクス技術の展開

  竹田浩章; 松沢佑紀; 建田潮; 高橋みき子; 竹内愛美; 栗崎優斗; 長谷川真由; 宮本潤基; 津川裕司

  脂質生化学研究, May 2024

  
• MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

  Hiroaki Takeda; Yuki Matsuzawa; Manami Takeuchi; Mikiko Takahashi; Kozo Nishida; Takeshi Harayama; Yoshimasa Todoroki; Kuniyoshi Shimizu; Nami Sakamoto; Takaki Oka; Masashi Maekawa; Mi Hwa Chung; Yuto Kurizaki; Saki Kiuchi; Kanako Tokiyoshi; Bujinlkham Buyantogtokh; Misaki Kurata; Aleš Kvasnička; Ushio Takeda; Haruki Uchino; Mayu Hasegawa; Junki Miyamoto; Kana Tanabe; Shigenori Takeda; Tetsuya Mori; Ryota Kumakubo; Tsuyoshi Tanaka; Tomoko Yoshino; Makoto Arita; Hiroshi Tsugawa

  bioRxiv, 08 Feb. 2024, Lead author

  
• In-depth profiling of sphingolipids by electron activated dissociation mass spectrometry

  竹田浩章; 建田潮; 竹内愛美; 松沢佑紀; 清水邦善; 長谷川真由; 宮本潤基; 津川裕司

  日本糖質学会年会要旨集, 2024

  
• A procedure for solid phase extractions using metal oxide coated silica column in lipidomics

  Hiroaki Takeda; Manami Takeuchi; Mayu Hasegawa; Junki Miyamoto; Hiroshi Tsugawa

  bioRxiv, 18 Oct. 2023, Lead author, Corresponding author

  
• Using data-dependent and independent hybrid acquisitions for fast liquid chromatography-based untargeted lipidomics

  Kanako Tokiyoshi; Yuki Matsuzawa; Mikiko Takahashi; Hiroaki Takeda; Mayu Hasegawa; Junki Miyamoto; Hiroshi Tsugawa

  bioRxiv, 17 Oct. 2023

  
• 質量分析計によるホスファチジルグルコシドとその分子種の解析法の確立 低酸素による小胞体ストレス応答への関わり

  花房慶; 竹田浩章; 洪慧馨; 柳田光昭; 梅津綾子; 狩野航輝; 松尾一郎; 中山仁志; 平林義雄; 岩渕和久

  脂質生化学研究, May 2023

  
• Toward the Next Generation of Lipidomics by Using Electron Activated Dissociation

  Hiroaki Takeda

  Journal of the Mass Spectrometry Society of Japan, 01 Mar. 2023

  
• Analysis of molecular species of phosphatidylglucoside composed of saturated fatty acid chains

  花房慶; 竹田浩章; HUNG Hui-Hsing; 柳田光昭; 梅津綾子; 狩野航輝; 松尾一郎; 中山仁志; 平林義雄; 岩渕和久

  日本糖質学会年会要旨集, 2023

  
• オミクスデータ科学を支えるMS-DIALワークベンチの開発

  津川裕司; 松沢佑紀; 西田孝三; 竹田浩章

  トーゴーの日2022, 05 Oct. 2022

  
• nano-LC-MS/MSによる生理活性脂質リゾホスファチジルグルコシドの高感度定量分析法の開発

  花房慶; 竹田浩章; 菅原綾乃; 柳田光昭; 狩野航輝; 松尾一郎; 中嶋和紀; 上口裕之; 中山仁志; 平林義雄; 岩渕和久

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• Separation techniques of supercritical fluid chromatography for study on sphingoglycolipids

  竹田浩章

  糖鎖科学コンソーシアムシンポジウム 第18回糖鎖研究と他領域との統合 リブート、糖鎖科学!-さらなる高みへ 令和3年, 2021

  
• Quantitative Lipidome Analysis for Separating Lipids with ω-3 Fatty Acids

  竹田浩章; 和泉自泰; 馬場健史

  月刊バイオインダストリー【特集】ω-3脂肪酸, Oct. 2020

  
• HDL機能低下と心筋梗塞発症に関与する脂質分子の探索

  小倉正恒; 竹田浩章; 和泉自泰; 馬場健史; 斯波真理子

  脂質生化学研究, 20 Jun. 2019

  
• 超臨界流体クロマトグラフィー三連四重極型質量分析によるワイドターゲット定量リピドーム分析法の開発

  高橋政友; 竹田浩章; 和泉自泰; 馬場健史

  質量分析総合討論会講演要旨集, 26 Apr. 2019

  
• Participation Report of 66th ASMS Conference on Mass Spectrometry and Allied Topics

  Hiroaki Takeda

  Journal of the Mass Spectrometry Society of Japan, 01 Dec. 2018

  
• Development of markers for progression of coronary plaques using WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi; Hiroaki Takeda; Yasuhiro Irino; Satoshi Yamada; Nobue Kuniyoshi; Yu Ying; Tomonari Koike; Yoshihiro Izumi; Masakazu Shinohara; Takeshi Bamba; Tatsuro Ishida

  Atherosclerosis, Aug. 2018

  
• WHHLMIウサギにおける冠動脈病変の発生・進行に関わる血漿マーカーの同定

  塩見雅志; 竹田浩章; 入野康宏; ユウ イン; 小池智也; 和泉自泰; 篠原正和; 石田達郎

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 25 Jun. 2018

  
• Identification of Novel Lipid Markers for Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model of Familial Hypercholesterolemia

  Masashi Shiomi; Hiroaki Takeda; Yasuhiro Irino; Satoshi Yamada; Nobue Kuniyoshi; Yui Koike; Tomonari Koike; Yoshihiro Izumi; Masakazu Shinohara; Takeshi Bamba; Tatsuro Ishida

  Atherosclerosis Supplements, Jun. 2018

  
• WHHLMIウサギにおける冠動脈病変の発生・進行に関わる血漿マーカー

  塩見雅志; 竹田浩章; 入野康宏; ユウ イン; 小池智也; 和泉自泰; 篠原正和; 馬場健史; 石田達郎

  日本実験動物学会総会講演要旨集, 27 Apr. 2018

  
• 質量分析技術を基盤とした動脈硬化性心血管疾患のリポタンパク質代謝解析

  竹田浩章

  九州大学博士学位論文, Mar. 2018

  
• 超臨界流体テクノロジーの新展開 超臨界流体クロマトグラフィーを用いた代謝物プロファイリング技術の開発と応用

  竹田浩章; 和泉自泰; 馬場健史

  生物工学会誌, 25 Jul. 2016

  
• 超臨界流体クロマトグラフィー三連四重極型質量分析によるワイドターゲット定量リピドミクス手法の開発

  竹田浩章; 和泉自泰; PAXTON Thanai; 加藤紀子; 堀江真之介; 長瀬勝敏; 馬場健史

  質量分析総合討論会講演要旨集, 09 May 2016

  
• Report of the 9th Summer School of Mass Spectrometry

  Hiroaki Takeda

  Journal of the Mass Spectrometry Society of Japan, 01 Feb. 2015

  
• Lipid profiling by supercritical fluid chromatography/mass spectrometry

  竹田浩章; 福崎英一郎; 馬場健史

  JSBMS Letters, 25 Jun. 2014

  
• 心筋梗塞自然発症モデルウサギのリポプロテイン脂質プロファイリング

  竹田浩章; 小池智也; 山田貴之; 和泉自泰; 塩見雅志; 吉田優; 福崎英一郎; 馬場健史

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  

Presentations

• High-Throughput and Sensitive Metabolite Analysis of Water-in-oil Droplets using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry

  Hiroaki Takeda; Ryogo Takai; Masamune Morita; Satoko Matsukura; Satoshi Matsuoka; Masaki Kanai; Koretsugu Ogata; Naohiro Noda; Daisuke Miura

  2025 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2025), 17 Dec. 2025

  
• Normal-Phase Supercritical Fluid Chromatography for Advanced Lipidomics: Quantitative Analysis and Glycolipid Separation

  Hiroaki Takeda; Manami Takeuchi; Masatomo Takahashi; Motonao Nakao; Daisuke Miura; Yoshihiro Izumi; Hiroshi Tsugawa; Takeshi Bamba

  2025 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2025), 16 Dec. 2025

  
• リピドミクスのà la carte ~高深度プロファイリングと構造解析、解析手法を添えて~

  竹田浩章

  第9回メタボロームシンポジウム若手会, 17 Oct. 2025, Invited

  
• クロマトグラフィーと質量分析のブレイクスルーによるリピドミクスの展望

  竹田浩章; 高橋政友; 竹内愛美; 和泉自泰; 馬場健史; 津川裕司

  第18回メタボロームシンポジウム, 24 Oct. 2024

  
• 電子励起解離搭載型の質量分析計を活用した糖脂質プロファイリングの高深度化

  竹田浩章; 建田潮; 竹内愛美; 松沢佑紀; 清水邦善; 長谷川真由; 宮本潤基; 津川裕司

  第43回日本糖質学会年会, 13 Sep. 2024

  
• In-depth structural lipidomics using solid-phase extraction and electron activated dissociation-based tandem mass spectrometry techniques

  Manami Takeuchi; Hiroaki Takeda; Yuki Matsuzawa; Takeshi Harayama; Masashi Maekawa; Mayu Hasegawa; Junki Miyamoto; Makoto Arita; Hiroshi Tsugawa

  20th Annual Conference of the Metabolomics Society (Metabolomics 2024), 20 Jun. 2024

  
• MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

  Hiroshi Tsugawa; Hiroaki Takeda; Yuki Matsuzawa; Manami Takeuchi; Mikiko Takahashi; Kozo Nishida; Takeshi Harayama; Makoto Arita

  20th Annual Conference of the Metabolomics Society (Metabolomics 2024), 19 Jun. 2024

  
• Elucidating the responsible cell- and genes for brain-specific acylated cerebroside

  Kuniyoshi Shimizu; Hiroaki Takeda; Manami Takeuchi; Nami Sakamoto; Takeshi Harayama; Hiroshi Tsugawa

  20th Annual Conference of the Metabolomics Society (Metabolomics 2024), 19 Jun. 2024

  
• 脂質多様性の解明に向けた高深度リピドミクス技術の展開

  竹田浩章; 松沢佑紀; 建田潮; 高橋みき子; 竹内愛美; 栗崎優斗; 長谷川真由; 宮本潤基; 津川裕司

  第66回日本脂質生化学会, 07 Jun. 2024

  
• 脂質の生化学的意義の解明につながる質量分析の最新データ

  竹田浩章; 建田潮

  第66回日本脂質生化学会 SCIEXランチョンセミナー, 07 Jun. 2024, Invited

  
• MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

  Hiroshi Tsugawa; Hiroaki Takeda; Yuki Matsuzawa; Manami Takeuchi; Mikiko Takahashi; Kozo Nishida; Takeshi Harayama; Makoto Arita

  72rd Conference on Mass Spectrometry and Allied Topics (ASMS 2024), 04 Jun. 2024

  
• リピドミクスの高深度化や定量化を加速させるクロマトグラフィー質量分析の最新技術

  竹田浩章

  群馬大学桐生キャンパス 第8回生体分子化学セミナー, 17 May 2024, Invited

  
• In-depth structural omics approaches for understanding lipid diversity

  竹田浩章

  第1回有田リピドームアトラス公開シンポジウム, 17 Oct. 2023

  
• 構造多様性の解析と個々の定量化を目指したマルチリピドーム計測技術の開発

  竹田浩章; 高橋政友; 和泉自泰; 馬場健史; 津川裕司

  第16回メタボロームシンポジウム, 15 Sep. 2022

  
• Quantitative lipidomics by supercritical fluid chromatography mass spectrometry and its latest applications

  Hiroaki Takeda

  第13回JBFシンポジウム, 28 Feb. 2022, Invited

  
• Separation techniques of supercritical fluid chromatography for study on sphingoglycolipids

  Hiroaki Takeda

  第18回糖鎖科学コンソーシアムシンポジウム, 08 Dec. 2021, Invited

  
• Development of a widely-targeted quantitative lipidomics methodology by supercritical fluid chromatography coupled with triple quadrupole mass spectrometry

  Hiroaki Takeda; Yoshihiro Izumi; Masatomo Takahashi; Motonao Nakao; Takeshi Bamba

  17th Annual Conference of the Metabolomics Society (Metabolomics 2021), 22 Jun. 2021

  
• 超臨界流体クロマトグラフィーの分離特性を利用した生体脂質の定量分析

  竹田浩章

  第21回SFC研究会, 29 Jan. 2021, Invited

  
• Lipidomic analysis for the prediction of cholesterol efflux capacity and atherosclerotic cardiovascular disease

  Masatsune Ogura; Hiroaki Takeda; Yoshihiro Izumi; Mika Hori; Kota Matsuki; Masashi Yamamoto; Takeshi Bamba; Mariko Harada-Shiba

  60th International Conference on the Bioscience of Lipids (ICBL 2019), Jun. 2019

  
• 脂質代謝の理解を目指した生体脂質分子の一斉定量分析法の構築

  竹田浩章; 和泉自泰; Thanai Paxton; 田村翔平; 小池智也; Ying Yu; 加藤紀子; 長瀬勝敏; 塩見雅志; 馬場健史

  第5回日本ウサギバイオサイエンス研究会学術集会・WHHLMIウサギ研究発表会, 20 Jul. 2018

  
• Analysis of lipoprotein metabolism in atherosclerotic cardiovascular disease based on lipidomics and targeted proteomics combined approach

  Hiroaki Takeda; Yoshihiro Izumi; Kohta Nakatani; Kosuke Hata; Tomonari Koike; Ying Yu; Fumio Matsuda; Masaki Matsumoto; Masashi Shiomi; Takeshi Bamba

  66rd Conference on Mass Spectrometry and Allied Topics (ASMS 2018), Jun. 2018

  
• Identification of novel lipid markers for coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi; Hiroaki Takeda; Yasuhiro Irino; Satoshi Yamada; Nobue Kuniyoshi; Yu Ying; Tomonari Koike; Norie Tsukada; Yoshihiro Izumi; Masakazu Shinohara; Takeshi Bamba; Tatsuro Ishida

  13th International Symposium on Atherosclerosis, Jun. 2018

  
• Development of markers for progression of coronary plaques using WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi; Hiroaki Takeda; Yasuhiro Irino; Satoshi Yamada; Nobue Kuniyoshi; Yu Ying; Tomonari Koike; Yoshihiro Izumi; Masakazu Shinohara; Takeshi Bamba; Tatsuro Ishida

  86th European Atherosclerosis Society Congress, May 2018

  
• オミクス解析に基づく血中リポタンパク質脂質解析法の開発

  竹田浩章; 和泉自泰; Thanai Paxton; 加藤紀子; 堀江真之介; 長瀬勝敏; 小池智也; 塩見雅志; 松田史生; 福崎英一郎; 馬場健史

  第7回学際的脂質創生研究部会講演会, 27 Jan. 2017

  
• Development of a wide-targeted quantitative lipidomics methodology by supercritical fluid chromatography coupled with fast-scanning triple quadrupole mass spectrometry

  Hiroaki Takeda; Yoshihiro Izumi; Thanai Paxton; Noriko Kato; Shinnosuke Horie; Katsutoshi Nagase; Takeshi Bamba

  64rd Conference on Mass Spectrometry and Allied Topics (ASMS 2016), Jun. 2016

  
• Lipidome analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits

  Hiroaki Takeda; Tomonari Koike; Yoshihiro Izumi; Takayuki Yamada; Masaru Yoshida; Masashi Shiomi; Eiichiro Fukusaki; Takeshi Bamba

  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015), Dec. 2015

  
• 心筋梗塞自然発症モデルウサギにおける血漿リポプロテイン画分のリピドーム解析

  竹田浩章; 小池智也; 和泉自泰; 山田貴之; 吉田優; 塩見雅志; 福崎英一郎; 馬場健史

  第5回学際的脂質創生研究部会講演会, 23 Jan. 2015

  
• 心筋梗塞自然発症モデルウサギのリポプロテイン脂質プロファイリング

  竹田浩章; 小池智也; 山田貴之; 和泉自泰; 塩見雅志; 吉田優; 福崎英一郎; 馬場健史

  日本農芸化学会2014年度大会

  

Books and Other Publications

• Chapter 7: Quantitative Lipidomics of Biological Samples Using Supercritical Fluid Chromatography Mass Spectrometry

  Hiroaki Takeda; Yoshihiro Izumi; Takeshi Bamba

  Methods in Molecular Biology, Metabolic Profiling, Methods and Protocols (Edited by Olga Deda, Helen G. Gika, Ian D. Wilson), Humana, New York, NY, 16 Jan. 2025

  Find Kyoto University's collection of books :

  
• 第4章 ω-3脂肪酸含有脂質を識別する定量リピドーム解析技術

  竹田浩章; 和泉自泰; 馬場健史

  オメガ3脂肪酸の技術と市場, シーエムシー出版, Apr. 2021

  
• Supercritical Fluid

  Yoshihiro Izumi; Hiroaki Takeda; Takeshi Bamba

  Encyclopedia of Lipidomics (Edited by Markus R. Wenk), Springer, Dordrecht, 20 Nov. 2016

  Find Kyoto University's collection of books :

  
• Supercritical Fluid Extraction: Carbon Dioxide

  Hiroaki Takeda; Yoshihiro Izumi; Takeshi Bamba

  Encyclopedia of Lipidomics (Edited by Markus R. Wenk), Springer, Dordrecht, 21 Jul. 2016

  Find Kyoto University's collection of books :

  
• Supercritical Fluid Extraction: Modifier

  Hiroaki Takeda; Yoshihiro Izumi; Takeshi Bamba

  Encyclopedia of Lipidomics (Edited by Markus R. Wenk), Springer, Dordrecht, 20 Jul. 2016

  Find Kyoto University's collection of books :

  
• 第3章 データの活用 2. 超臨界流体抽出分離技術を用いた代謝プロファイリング

  和泉自泰; 竹田浩章; 馬場健史

  ヘルスケアを支えるバイオ計測, シーエムシー出版, Mar. 2016, Not refereed

  

Awards

• Jul. 2018

  日本ウサギバイオサイエンス研究会, 第5回日本ウサギバイオサイエンス研究会学術集会・WHHLMIウサギ研究発表会 優秀発表賞
• May 2018

  日本質量分析学会, 2018年度 日本質量分析学会トラベルアワード
• 20 Mar. 2018

  九州大学学生表彰

Media Coverage

• 水が脂質の構造を解き明かす？ － 未知の異性体の発見とその機能を紐解く研究に貢献 －

  東京農工大学, プレスリリース, 14 May 2025, Others

  
• 複雑な脂肪酸構造を解析する新技術を開発 － 脂肪酸代謝の多様性を捉えるリピドミクス －

  東京農工大学, プレスリリース, 04 Apr. 2025, Others

  
• 複雑かつ多様な脂質代謝を解明する情報解析プログラム － マルチモーダル質量分析により脂質構造と局在を紐解く －

  東京農工大学, プレスリリース, 28 Nov. 2024, Others

  
• 生命の脂質多様性を紐解く精製技術を開発 － 分画と濃縮により未知の脂質分子の発見を加速 －

  東京農工大学, プレスリリース, 28 Oct. 2024, Others

  
• 生体の脂質多様性をより短時間で解析する手法を開発 － 計測手法と情報処理技術の改良で大規模解析研究を加速 －

  東京農工大学, プレスリリース, 11 Jan. 2024, Others

  

External funds: Kakenhi

• Charting the Spatiotemporal Landscape of Brain Gangliosides through Glycolipidomics

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  竹田 浩章

  From 26 Jun. 2026, To 31 Mar. 2028, Granted

  ガングリオシド;神経化学;神経発達;構造推定;イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K22925/

Academic, Social Contribution

Committee Memberships

• From Sep. 2014

  実行委員長, 第9回質量分析夏の学校

Academic Contribution

• 第9回メタボロームシンポジウム若手会

  Panel moderator

  From 17 Oct. 2025

  
• 第8回メタボロームシンポジウム若手会

  Panel moderator

  From 25 Oct. 2024

  
• 第66回日本脂質生化学会

  Panel moderator

  From 07 Jun. 2024

  
• Mass Spectrometry

  Peer review

  From 2023