Basic Information

Faculty

• Faculty of Engineering

Professional Memberships

• 日本生化学会
• JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
• THE CHEMICAL SOCIETY OF JAPAN

Academic Degree

• 修士(工学)(九州大学)
• 博士(工学)(京都大学)

Academic Resume (Graduate Schools)

• 九州大学, 大学院工学府修士課程物質創造工学専攻, 修了
• 京都大学, 大学院工学研究科博士後期課程合成･生物化学専攻, 修了

Research History

• From Feb. 2025, To Present

  Kyoto University, Graduate School of Engineering, Associate Professor
• From Apr. 2019, To Mar. 2025

  JST ERATO浜地ニューロ分子技術プロジェクト, 研究総括補佐
• From Mar. 2019, To Mar. 2025

  Japan Science and Technology Agency, グループリーダー
• From Mar. 2019, To Jan. 2025

  Kyoto University, Graduate School of Engineering, 特定准教授
• From Feb. 2015, To Jan. 2019

  The University of Tokyo, 工学(系)研究科(研究院), 講師
• From Aug. 2014, To Jan. 2015

  東京大学 工学系研究科, 助教
• From Feb. 2010, To Jul. 2014

  九州大学稲盛フロンティア研究センタ−, 特任助教

ID,URL

• ORCID ID

  0000-0003-4623-2926

• J-Global ID

  201501052546066091

researchmap URL

• https://researchmap.jp/space

Research

Research Interests

• グリア
• 脳
• タンパク質の化学標識
• 核偏極
• 核磁気共鳴
• 細胞間情報伝達物質
• センサー
• イメージング
• 機能性核酸
• 蛍光イメージング
• 核酸
• 伝達物質
• アプタマー
• アデニンヌクレオチド

Research Areas

• Nanotechnology/Materials, Chemical biology
• Nanotechnology/Materials, Biochemistry

Papers

• Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides.

  Yohei Kondo; Yutaro Saito; Tomohiro Seki; Yoichi Takakusagi; Norikazu Koyasu; Keita Saito; Jumpei Morimoto; Hiroshi Nonaka; Koichiro Miyanishi; Wataru Mizukami; Makoto Negoro; Abdelazim E Elhelaly; Fuminori Hyodo; Masayuki Matsuo; Natarajan Raju; Rolf E Swenson; Murali C Krishna; Kazutoshi Yamamoto; Shinsuke Sando

  Science advances, 18 Oct. 2024, Peer-reviewed

  
• P2Y12 receptor ligands enable design of fluorescent imaging probes for microglia

  Hiroshi Nonaka; Mengchu Wang; Itaru Hamachi

  Chemistry Letters, 04 Oct. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging.

  Takeharu Mino; Hiroshi Nonaka; Itaru Hamachi

  Current opinion in chemical biology, Aug. 2024, Peer-reviewed

  
• Photoproximity labeling of endogenous receptors in the live mouse brain in minutes.

  Mikiko Takato; Seiji Sakamoto; Hiroshi Nonaka; Fátima Yuri Tanimura Valor; Tomonori Tamura; Itaru Hamachi

  Nature chemical biology, 01 Aug. 2024, Peer-reviewed

  
• Nanoscale organization is changed in native, surface AMPARs by mouse brain region and tauopathy.

  Rohit M Vaidya; Jiahao Zhang; Duncan Nall; Yongjae Lee; Eung Chang Kim; Donghan Ma; Fang Huang; Hiroshi Nonaka; Shigeki Kiyonaka; Itaru Hamachi; Hee Jung Chung; Paul R Selvin

  bioRxiv : the preprint server for biology, 23 Jul. 2024

  
• Molecular technology for highly sensitive biomolecular analysis: Hyperpolarized NMR/MRI probes

  Shinsuke Sando; Hiroshi Nonaka

  Molecular Technology: Materials Innovation, 06 Feb. 2019

  
• Protocol to visualize the distribution of exogenously administered small molecules in the mouse brain

  Takeharu Mino; Hiroshi Nonaka; Seiji Sakamoto; Jae Hoon Oh; Itaru Hamachi

  STAR Protocols, Sep. 2023, Peer-reviewed

  Access this paper :

  
• Tyrosinase-Based Proximity Labeling in Living Cells and In Vivo

  Hao Zhu; Jae Hoon Oh; Yuna Matsuda; Takeharu Mino; Mamoru Ishikawa; Hideki Nakamura; Muneo Tsujikawa; Hiroshi Nonaka; Itaru Hamachi

  Journal of the American Chemical Society, 06 Mar. 2024, Peer-reviewed

  
• Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains.

  Hiroshi Nonaka; Seiji Sakamoto; Kazuki Shiraiwa; Mamoru Ishikawa; Tomonori Tamura; Kyohei Okuno; Takumi Kondo; Shigeki Kiyonaka; Etsuo A Susaki; Chika Shimizu; Hiroki R Ueda; Wataru Kakegawa; Itaru Arai; Michisuke Yuzaki; Itaru Hamachi

  Proceedings of the National Academy of Sciences of the United States of America, 06 Feb. 2024, Peer-reviewed, Lead author

  Access this paper :

  
• Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

  Hiroshi Nonaka; Takeharu Mino; Seiji Sakamoto; Jae Hoon Oh; Yu Watanabe; Mamoru Ishikawa; Akihiro Tsushima; Kazuma Amaike; Shigeki Kiyonaka; Tomonori Tamura; A. Radu Aricescu; Wataru Kakegawa; Eriko Miura; Michisuke Yuzaki; Itaru Hamachi

  Chem, Feb. 2023, Peer-reviewed, Lead author

  Access this paper :

  
• Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state.

  Yohei Kondo; Yutaro Saito; Abdelazim Elsayed Elhelaly; Fuminori Hyodo; Tatsuya Nishihara; Marino Itoda; Hiroshi Nonaka; Masayuki Matsuo; Shinsuke Sando

  RSC advances, 17 Nov. 2021, Peer-reviewed

  
• Structure-based relaxation analysis reveals C-terminal [1-13C]glycine-d2 in peptides has long spin-lattice relaxation time that is applicable to in vivo hyperpolarized magnetic resonance studies

  Yohei Kondo; Yutaro Saito; Tomohiro Seki; Yoichi Takakusagi; Jumpei Morimoto; Hiroshi Nonaka; Koichiro Miyanishi; Wataru Mizukami; Makoto Negoro; Abdelazim Elsayed Elhelaly; Fuminori Hyodo; Masayuki Matsuo; Natarajan Raju; Rolf Swenson; Murali C. Krishna; Kazutoshi Yamamoto; Shinsuke Sando

  28 Jan. 2022

  
• Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue.

  Kento Ojima; Wataru Kakegawa; Tokiwa Yamasaki; Yuta Miura; Masayuki Itoh; Yukiko Michibata; Ryou Kubota; Tomohiro Doura; Eriko Miura; Hiroshi Nonaka; Seiya Mizuno; Satoru Takahashi; Michisuke Yuzaki; Itaru Hamachi; Shigeki Kiyonaka

  Nature communications, 16 Jun. 2022, Peer-reviewed

  Access this paper :

  
• Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging.

  Yohei Kondo; Hiroshi Nonaka; Yoichi Takakusagi; Shinsuke Sando

  Angewandte Chemie (International ed. in English), 25 Jun. 2021, Peer-reviewed

  
• Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.

  Tomoki Ota; Akinobu Senoo; Masumi Shirakawa; Hiroshi Nonaka; Yutaro Saito; Sho Ito; Go Ueno; Satoru Nagatoishi; Kouhei Tsumoto; Shinsuke Sando

  iScience, 19 Feb. 2021, Peer-reviewed

  
• Chemical Tools for Endogenous Protein Labeling and Profiling

  Shiraiwa, K.; Cheng, R.; Nonaka, H.; Tamura, T.; Hamachi, I.

  Cell Chemical Biology, 2020, Peer-reviewed

  
• ¹³C Dynamic Nuclear Polarization using SA-BDPA at 6.7 T and 1.1 K: Coexistence of Pure Thermal Mixing and Well-Resolved Solid Effect

  Radaelli, A.; Yoshihara, H.A.I.; Nonaka, H.; Sando, S.; Ardenkjaer-Larsen, J.H.; Gruetter, R.; Capozzi, A.

  Journal of Physical Chemistry Letters, 2020, Peer-reviewed

  
• Structural exploration of rhodium catalysts and their kinetic studies for efficient parahydrogen-induced polarization by side arm hydrogenation

  Itoda, M.; Naganawa, Y.; Ito, M.; Nonaka, H.; S; o, S.

  RSC Advances, Jun. 2019, Peer-reviewed

  
• Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction.

  Nonaka H; Nakanishi Y; Kuno S; Ota T; Mochidome K; Saito Y; Sugihara F; Takakusagi Y; Aoki I; Nagatoishi S; Tsumoto K; Sando S

  Nature communications, Feb. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Dynamic nuclear polarization with photo-excited triplet electrons using 6,13-diphenylpentacene

  Tateishi, K.; Negoro, M.; Nonaka, H.; Kagawa, A.; Sando, S.; Wada, S.; Kitagawa, M.; Uesaka, T.

  Physical Chemistry Chemical Physics, 2019, Peer-reviewed

  
• Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection.

  Tatsuya Nishihara; Satoshi Kuno; Hiroshi Nonaka; Sho Tabata; Natsumi Saito; Shinji Fukuda; Masaru Tomita; Shinsuke Sando; Tomoyoshi Soga

  Chemical communications (Cambridge, England), 16 Oct. 2018, Peer-reviewed

  
• Rational Design of [13C,D14]Tert-butylbenzene as a Scaffold Structure for Designing Long-lived Hyperpolarized 13C Probes

  Yuki Imakura; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Nesmine R. Maptue; Alexander M. Funk; Chalermchai Khemtong; Shinsuke Sando

  Chemistry - An Asian Journal, 02 Feb. 2018, Peer-reviewed, Corresponding author

  
• A Strategy to Design Hyperpolarized C-13 Magnetic Resonance Probes Using [1-C-13]-Amino Acid as a Scaffold Structure

  Nishihara, Tatsuya; Kameyama, Yutaka; Nonaka, Hiroshi; Takakusagi, Yoichi; Hyodo, Fuminori; Ichikawa, Kazuhiro; Sando, Shinsuke

  CHEMISTRY-AN ASIAN JOURNAL, May 2017, Peer-reviewed

  
• Design of a N-15 Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

  Hiroshi Nonaka; Masashi Hirano; Yuki Imakura; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando

  SCIENTIFIC REPORTS, Jan. 2017, Peer-reviewed, Lead author, Corresponding author

  
• Direct Monitoring of -Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized C-13-Labeled Molecular Probe

  Nishihara, Tatsuya; Yoshihara, Hikari A. I.; Nonaka, Hiroshi; Takakusagi, Yoichi; Hyodo, Fuminori; Ichikawa, Kazuhiro; Can, Emine; Bastiaansen, Jessica A. M.; Takado, Yuhei; Comment, Arnaud; Sando, Shinsuke

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Aug. 2016, Peer-reviewed

  
• Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity

  Ryunosuke Hata; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jan. 2016, Peer-reviewed

  
• Phenylboronic Acid-based F-19 MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

  Hiroshi Nonaka; Qi An; Fuminori Sugihara; Tomohiro Doura; Akira Tsuchiya; Yoshichika Yoshioka; Shinsuke Sando

  ANALYTICAL SCIENCES, Apr. 2015, Peer-reviewed, Lead author

  
• Design of a hyperpolarized N-15 NMR probe that induces a large chemical-shift change upon binding of calcium ions

  Ryunosuke Hata; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando

  CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed

  
• Design of Triple-resonance NMR Reporter Assay

  Tatsuya Nishihara; Hiroshi Nonaka; Shinsuke Sando

  CHEMISTRY LETTERS, Dec. 2014, Peer-reviewed

  
• In-cell covalent labeling of reactive His-tag fused proteins

  Shohei Uchinomiya; Hiroshi Nonaka; Sho Wakayama; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• An adhesive F-19 MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment

  Tomohiro Doura; Ryunosuke Hata; Hiroshi Nonaka; Fuminori Sugihara; Yoshichika Yoshioka; Shinsuke Sando

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• A platform for designing hyperpolarized magnetic resonance chemical probes

  Hiroshi Nonaka; Ryunosuke Hata; Tomohiro Doura; Tatsuya Nishihara; Keiko Kumagai; Mai Akakabe; Masashi Tsuda; Kazuhiro Ichikawa; Shinsuke Sando

  Nature Communications, 2013, Peer-reviewed, Lead author

  
• H-1 NMR Probe for in Situ Monitoring of Dopamine Metabolism and Its Application to Inhibitor Screening

  Ryosuke Ueki; Koya Yamaguchi; Hiroshi Nonaka; Shinsuke Sando

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012, Peer-reviewed

  
• Cell Surface-Anchored Fluorescent Aptamer Sensor Enables Imaging of Chemical Transmitter Dynamics

  Takeshi Tokunaga; Shigeyuki Namiki; Katsuhiro Yamada; Takahiro Imaishi; Hiroshi Nonaka; Kenzo Hirose; Shinsuke Sando

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2012, Peer-reviewed

  
• Mouse lactate dehydrogenase X: A promising magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative Y

  Tatsuya Nishihara; Hiroshi Nonaka; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando

  CHEMICAL SCIENCE, 2012, Peer-reviewed

  
• Atom arrangement strategy for designing a turn-on H-1 magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite

  Tomohiro Doura; Hiroshi Nonaka; Shinsuke Sando

  CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed

  
• Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

  Sho-hei Fujishima; Hiroshi Nonaka; Sho-hei Uchinomiya; Yoshiyuki Alex Kawase; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, Jan. 2012, Peer-reviewed

  
• Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit

  Tomohiro Doura; Ryunosuke Hata; Hiroshi Nonaka; Kazuhiro Ichikawa; Shinsuke Sando

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Design of Chemical Shift-Switching F-19 Magnetic Resonance Imaging Probe for Specific Detection of Human Monoamine Oxidase A

  Koya Yamaguchi; Ryosuke Ueki; Hiroshi Nonaka; Fuminori Sugihara; Tetsuya Matsuda; Shinsuke Sando

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2011, Peer-reviewed

  
• Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts

  Hangxiang Wang; Yoichiro Koshi; Daishiro Minato; Hiroshi Nonaka; Shigeld Kiyonaka; Yasuo Mori; Shinya Tsukiji; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed

  
• In situ analysis of [8-C-13-7-N-15]-double-labelled theophylline by a triple resonance NMR technique

  Koya Yamaguchi; Ryosuke Ueki; Hisatsugu Yamada; Yasuhiro Aoyama; Hiroshi Nonaka; Shinsuke Sando

  ANALYTICAL METHODS, Jul. 2011, Peer-reviewed

  
• Rigid Luminescent Bis-Zinc(II)-Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution

  Mouchumi Bhuyan; Evgeny Katayev; Stefan Stadlbauer; Hiroshi Nonaka; Akio Ojida; Itaru Hamachi; Burkhard Koenig

  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, May 2011, Peer-reviewed

  
• Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis

  Hiroshi Nonaka; Sho-hei Fujishima; Sho-hei Uchinomiya; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2010, Peer-reviewed, Lead author

  Access this paper :

  
• Binuclear Ni-II-DpaTyr Complex as a High Affinity Probe for an Oligo-Aspartate Tag Tethered to Proteins

  Akio Ojida; Sho-hei Fujishima; Kei Honda; Hiroshi Nonaka; Sho-hei Uchinomiya; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, 2010, Peer-reviewed

  Access this paper :

  
• FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction

  Hiroshi Nonaka; Sho-hei Fujishima; Sho-hei Uchinomiya; Akio Ojida; Itaru Hamachi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Dec. 2009, Peer-reviewed, Lead author

  Access this paper :

  
• Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(II)-NTA probe

  Sho-hei Uchinomiya; Hiroshi Nonaka; Sho-hei Fujishima; Shinya Tsukiji; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2009, Peer-reviewed

  Access this paper :

  
• Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene Zn-II-Dpa Chemosensor

  Takahiro Kohira; Ippei Takashima; Hiroshi Nonaka; Akio Ojida; Itaru Hamachi

  CHEMISTRY LETTERS, Nov. 2008, Peer-reviewed

  Access this paper :

  
• Turn-on fluorescence sensing of nucleoside polyphosphates using a xanthene-based Zn(II) complex chemosensor

  Akio Ojida; Ippei Takashima; Takahiro Kohira; Hiroshi Nonaka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2008, Peer-reviewed

  Access this paper :

  
• Non-enzymatic covalent protein labeling using a reactive tag

  Hiroshi Nonaka; Shinya Tsukiji; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2007, Peer-reviewed, Lead author

  Access this paper :

  
• Bis(Dpa-Zn-II) appended xanthone: Excitation ratiometric chemosensor for phosphate anions

  Akio Ojida; Hiroshi Nonaka; Yoshifumi Miyahara; Shun-ichi Tamaru; Kazuki Sada; Itaru Hamachi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

  Access this paper :

  

Misc.

• Development of a Protein Labeling Method Using Small Molecular Probes

  OJIDA Akio; NONAKA Hiroshi; HAMACHI Itaru

  Bioscience & industry, 01 May 2010

  
• 生体内 β-ガラクトシダーゼ活性検出に向けた高感度-核磁気共鳴分子プローブの検討

  近藤 洋平; 坂本 大地; 野中 洋; 高草木 洋一; 山本 和俊; Murali C Krishna; 青木 伊知男; 山東 信介

  第 14 回 日本分子イメージング学会総会・学術集会, May 2019, Peer-reviewed

  
• APN 活性イメージングを目指した CEST MRI 分子プローブの設計

  森田峻平; 近藤洋平; 野中洋; 高草木洋一; 青木伊知男; 山東信介

  第 13 回 日本分子イメージング学会総会・学術集会, Jun. 2018

  
• β-ガラクトシダーゼ活性の検出を指向した化学交換飽和移動を用いる核磁気共鳴分子プローブの検討

  近藤洋平; 野中洋; 高草木洋一; 青木伊知男; 山東信介

  第 13 回 日本分子イメージング学会総会・学術集会, Jun. 2018

  
• Application of a novel 13C hyperpolarized metabolic tracer for gamma-Glutamyl transferase activity in vivo tumor xenograft

  Tomohiro Seki; Marino Itoda; Shun Kishimoto; Kazu Yamamoto; Yoichi Takakusagi; Jeffery Brender; Ronja M. Malinowski; Tatsuya Nishihara; Hikari A.I. Yoshihara; Hiroshi Nonaka; Keita Saito; Nobu Oshima; Jan H. Ardenkjær-Larsen; James B. Mitchell; Murali C. Krishna; Shinsuke Sando

  International Society for Magnetic Resonance in Medicine (ISMRM) 2018, Jun. 2018, Peer-reviewed

  
• Exploration of molecular structures having a long hyperpolarization lifetime and its application for highly sensitive magnetic resonance probe

  Hiroshi Nonaka; Ryunosuke Hata; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012

  
• Development of Ca2+ indicator for hyperpolarized C-13 MRI

  Yutaka Kameyama; Hiroshi Nonaka; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012

  
• Magnetic resonance probe for selective detection of neurological disorder-related enzyme

  Ryosuke Ueki; Hiroshi Nonaka; Shinsuke Sando

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012

  
• Mouse lactate dehydrogenase X: A new magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative

  Tatsuya Nishihara; Hiroshi Nonaka; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012

  
• Selective protein labeling using reactive-tag system

  Hiroshi Nonaka; Shohei Uchinomiya; Shohei Fujishima; Akio Ojida; Itaru Hamachi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

  

External funds: Kakenhi

• 生きたマウス脳内でのミクログリア選択的化学修飾法の開発と近傍環境解析への応用

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37010:Bio-related chemistry

  Kyoto University

  野中 洋

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  ミクログリア;化学修飾;リガンド指向性化学;受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01627/
• Development of organic chemistry targeting biomolecules in live animals

  Grant-in-Aid for Specially Promoted Research

  Science and Engineering

  Kyoto University

  浜地 格

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  分子夾雑;生命化学;脳内有機化学;リガンド指向性化学;ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H05405/
• Development of molecular probes for metabolic reaction analysis at specific environmental sites in vivo

  Grant-in-Aid for Challenging Research (Exploratory)

  The University of Tokyo

  Hiroshi Nonaka

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  人工代謝物;分子プローブ;代謝;分析化学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19193/
• Development of a highly sensitive detection method using hyperpolarized nuclear magnetic resonance and meso-spaces

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  Hiroshi Nonaka

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  核磁気共鳴;核偏極;分子プローブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K13737/
• Development of hyperpolarized molecular probes toward in vivo redox analysis

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo;Kyushu University

  Hiroshi NONAKA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  核磁気共鳴;核偏極;酸化還元;分子プローブ;核超偏極

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25620135/
• development of functional nucleic acids toward fluorescense imaging of chemical transmitter dynamics

  Grant-in-Aid for Young Scientists (B)

  Kyushu University

  Hiroshi NONAKA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  核酸;アプタマー;伝達物質;イメージング;機能性核酸;細胞間情報伝達物質;アデニンヌクレオチド;センサー;蛍光イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23750194/
• 臓器間でやり取りされるメッセージ物質の可視化・動態解析法の開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  野中 洋

  From 28 Jun. 2024, To 31 Mar. 2026, Granted

  臓器連関;蛍光イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21824/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Analytical Chemistry of Materials, Advanced

  S016, Fall, Graduate School of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Analytical Chemistry (Frontier Chemistry)

  7114, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Chemical Science and Technology

  7501, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Instrumental Analysis (Frontier Chemistry)

  7126, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Analysis and Characterization of Materials II

  H034, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Frontier Chemistry Laboratory II(Frontier Chemistry)

  7136, Fall, Faculty of Engineering, 7
• From 01 Apr. 2025, To 31 Mar. 2026

  Frontier Chemistry Laboratory I(Frontier Chemistry)

  7135, Spring, Faculty of Engineering, 7