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Nonaka, Hiroshi

Graduate School of Engineering, Division of Synthetic Chemistry and Biological Chemistry Program-Specific Associate Professor

Nonaka, Hiroshi
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    Last Updated :2024/05/23

    Basic Information

    Professional Memberships

    • 日本生化学会
    • American Chemical Society
    • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
    • THE CHEMICAL SOCIETY OF JAPAN

    Academic Degree

    • 修士(工学)(九州大学)
    • 博士(工学)(京都大学)

    Academic Resume (Graduate Schools)

    • 九州大学, 大学院工学府修士課程物質創造工学専攻, 修了
    • 京都大学, 大学院工学研究科博士後期課程合成・生物化学専攻, 修了

    Research History

    • From Mar. 2019, To Present
      Japan Science and Technology Agency, グループリーダー
    • From Mar. 2019, To Present
      Kyoto University, Graduate School of Engineering, 特定准教授
    • From Feb. 2015, To Jan. 2019
      The University of Tokyo, 工学(系)研究科(研究院), 講師
    • From Aug. 2014, To Jan. 2015
      東京大学 工学系研究科, 助教
    • From Feb. 2010, To Jul. 2014
      九州大学稲盛フロンティア研究センタ−, 特任助教

    ID,URL

    researchmap URL

    list
      Last Updated :2024/05/23

      Research

      Research Interests

      • 核偏極
      • 核磁気共鳴
      • 細胞間情報伝達物質
      • センサー
      • イメージング
      • 機能性核酸
      • 蛍光イメージング
      • 核酸
      • 伝達物質
      • アプタマー
      • アデニンヌクレオチド

      Research Areas

      • Nanotechnology/Materials, Chemical biology
      • Nanotechnology/Materials, Biochemistry

      Papers

      • Tyrosinase-Based Proximity Labeling in Living Cells and In Vivo
        Hao Zhu; Jae Hoon Oh; Yuna Matsuda; Takeharu Mino; Mamoru Ishikawa; Hideki Nakamura; Muneo Tsujikawa; Hiroshi Nonaka; Itaru Hamachi
        Journal of the American Chemical Society, 06 Mar. 2024
      • Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains.
        Hiroshi Nonaka; Seiji Sakamoto; Kazuki Shiraiwa; Mamoru Ishikawa; Tomonori Tamura; Kyohei Okuno; Takumi Kondo; Shigeki Kiyonaka; Etsuo A Susaki; Chika Shimizu; Hiroki R Ueda; Wataru Kakegawa; Itaru Arai; Michisuke Yuzaki; Itaru Hamachi
        Proceedings of the National Academy of Sciences of the United States of America, 06 Feb. 2024
      • Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
        Hiroshi Nonaka; Takeharu Mino; Seiji Sakamoto; Jae Hoon Oh; Yu Watanabe; Mamoru Ishikawa; Akihiro Tsushima; Kazuma Amaike; Shigeki Kiyonaka; Tomonori Tamura; A. Radu Aricescu; Wataru Kakegawa; Eriko Miura; Michisuke Yuzaki; Itaru Hamachi
        Chem, Feb. 2023
      • Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state.
        Yohei Kondo; Yutaro Saito; Abdelazim Elsayed Elhelaly; Fuminori Hyodo; Tatsuya Nishihara; Marino Itoda; Hiroshi Nonaka; Masayuki Matsuo; Shinsuke Sando
        RSC advances, 17 Nov. 2021
      • Structure-based relaxation analysis reveals C-terminal [1-13C]glycine-d2 in peptides has long spin-lattice relaxation time that is applicable to in vivo hyperpolarized magnetic resonance studies
        Yohei Kondo; Yutaro Saito; Tomohiro Seki; Yoichi Takakusagi; Jumpei Morimoto; Hiroshi Nonaka; Koichiro Miyanishi; Wataru Mizukami; Makoto Negoro; Abdelazim Elsayed Elhelaly; Fuminori Hyodo; Masayuki Matsuo; Natarajan Raju; Rolf Swenson; Murali C. Krishna; Kazutoshi Yamamoto; Shinsuke Sando
        28 Jan. 2022
      • Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue.
        Kento Ojima; Wataru Kakegawa; Tokiwa Yamasaki; Yuta Miura; Masayuki Itoh; Yukiko Michibata; Ryou Kubota; Tomohiro Doura; Eriko Miura; Hiroshi Nonaka; Seiya Mizuno; Satoru Takahashi; Michisuke Yuzaki; Itaru Hamachi; Shigeki Kiyonaka
        Nature communications, 16 Jun. 2022
      • Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging.
        Yohei Kondo; Hiroshi Nonaka; Yoichi Takakusagi; Shinsuke Sando
        Angewandte Chemie (International ed. in English), 25 Jun. 2021
      • Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.
        Tomoki Ota; Akinobu Senoo; Masumi Shirakawa; Hiroshi Nonaka; Yutaro Saito; Sho Ito; Go Ueno; Satoru Nagatoishi; Kouhei Tsumoto; Shinsuke Sando
        iScience, 19 Feb. 2021
      • Chemical Tools for Endogenous Protein Labeling and Profiling
        Shiraiwa, K.; Cheng, R.; Nonaka, H.; Tamura, T.; Hamachi, I.
        Cell Chemical Biology, 2020
      • 13C Dynamic Nuclear Polarization using SA-BDPA at 6.7 T and 1.1 K: Coexistence of Pure Thermal Mixing and Well-Resolved Solid Effect
        Radaelli, A.; Yoshihara, H.A.I.; Nonaka, H.; Sando, S.; Ardenkjaer-Larsen, J.H.; Gruetter, R.; Capozzi, A.
        Journal of Physical Chemistry Letters, 2020
      • Structural exploration of rhodium catalysts and their kinetic studies for efficient parahydrogen-induced polarization by side arm hydrogenation
        Itoda, M.; Naganawa, Y.; Ito, M.; Nonaka, H.; S; o, S.
        RSC Advances, Jun. 2019, Peer-reviewed
      • Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction.
        Nonaka H; Nakanishi Y; Kuno S; Ota T; Mochidome K; Saito Y; Sugihara F; Takakusagi Y; Aoki I; Nagatoishi S; Tsumoto K; Sando S
        Nature communications, Feb. 2019, Peer-reviewed
      • Dynamic nuclear polarization with photo-excited triplet electrons using 6,13-diphenylpentacene
        Tateishi, K.; Negoro, M.; Nonaka, H.; Kagawa, A.; Sando, S.; Wada, S.; Kitagawa, M.; Uesaka, T.
        Physical Chemistry Chemical Physics, 2019
      • Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection.
        Tatsuya Nishihara; Satoshi Kuno; Hiroshi Nonaka; Sho Tabata; Natsumi Saito; Shinji Fukuda; Masaru Tomita; Shinsuke Sando; Tomoyoshi Soga
        Chemical communications (Cambridge, England), 16 Oct. 2018, Peer-reviewed
      • Rational Design of [13C,D14]Tert-butylbenzene as a Scaffold Structure for Designing Long-lived Hyperpolarized 13C Probes
        Yuki Imakura; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Nesmine R. Maptue; Alexander M. Funk; Chalermchai Khemtong; Shinsuke Sando
        Chemistry - An Asian Journal, 02 Feb. 2018, Peer-reviewed
      • A Strategy to Design Hyperpolarized C-13 Magnetic Resonance Probes Using [1-C-13]-Amino Acid as a Scaffold Structure
        Nishihara, Tatsuya; Kameyama, Yutaka; Nonaka, Hiroshi; Takakusagi, Yoichi; Hyodo, Fuminori; Ichikawa, Kazuhiro; Sando, Shinsuke
        CHEMISTRY-AN ASIAN JOURNAL, May 2017, Peer-reviewed
      • Design of a N-15 Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
        Hiroshi Nonaka; Masashi Hirano; Yuki Imakura; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando
        SCIENTIFIC REPORTS, Jan. 2017, Peer-reviewed
      • Direct Monitoring of -Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized C-13-Labeled Molecular Probe
        Nishihara, Tatsuya; Yoshihara, Hikari A. I.; Nonaka, Hiroshi; Takakusagi, Yoichi; Hyodo, Fuminori; Ichikawa, Kazuhiro; Can, Emine; Bastiaansen, Jessica A. M.; Takado, Yuhei; Comment, Arnaud; Sando, Shinsuke
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Aug. 2016, Peer-reviewed
      • Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity
        Ryunosuke Hata; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jan. 2016, Peer-reviewed
      • Phenylboronic Acid-based F-19 MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change
        Hiroshi Nonaka; Qi An; Fuminori Sugihara; Tomohiro Doura; Akira Tsuchiya; Yoshichika Yoshioka; Shinsuke Sando
        ANALYTICAL SCIENCES, Apr. 2015, Peer-reviewed
      • Design of a hyperpolarized N-15 NMR probe that induces a large chemical-shift change upon binding of calcium ions
        Ryunosuke Hata; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando
        CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed
      • Design of Triple-resonance NMR Reporter Assay
        Tatsuya Nishihara; Hiroshi Nonaka; Shinsuke Sando
        CHEMISTRY LETTERS, Dec. 2014
      • In-cell covalent labeling of reactive His-tag fused proteins
        Shohei Uchinomiya; Hiroshi Nonaka; Sho Wakayama; Akio Ojida; Itaru Hamachi
        CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed
      • An adhesive F-19 MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment
        Tomohiro Doura; Ryunosuke Hata; Hiroshi Nonaka; Fuminori Sugihara; Yoshichika Yoshioka; Shinsuke Sando
        CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed
      • A platform for designing hyperpolarized magnetic resonance chemical probes
        Hiroshi Nonaka; Ryunosuke Hata; Tomohiro Doura; Tatsuya Nishihara; Keiko Kumagai; Mai Akakabe; Masashi Tsuda; Kazuhiro Ichikawa; Shinsuke Sando
        Nature Communications, 2013, Peer-reviewed
      • H-1 NMR Probe for in Situ Monitoring of Dopamine Metabolism and Its Application to Inhibitor Screening
        Ryosuke Ueki; Koya Yamaguchi; Hiroshi Nonaka; Shinsuke Sando
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012, Peer-reviewed
      • Cell Surface-Anchored Fluorescent Aptamer Sensor Enables Imaging of Chemical Transmitter Dynamics
        Takeshi Tokunaga; Shigeyuki Namiki; Katsuhiro Yamada; Takahiro Imaishi; Hiroshi Nonaka; Kenzo Hirose; Shinsuke Sando
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2012, Peer-reviewed
      • Mouse lactate dehydrogenase X: A promising magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative Y
        Tatsuya Nishihara; Hiroshi Nonaka; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando
        CHEMICAL SCIENCE, 2012, Peer-reviewed
      • Atom arrangement strategy for designing a turn-on H-1 magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite
        Tomohiro Doura; Hiroshi Nonaka; Shinsuke Sando
        CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed
      • Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins
        Sho-hei Fujishima; Hiroshi Nonaka; Sho-hei Uchinomiya; Yoshiyuki Alex Kawase; Akio Ojida; Itaru Hamachi
        CHEMICAL COMMUNICATIONS, Jan. 2012, Peer-reviewed
      • Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit
        Tomohiro Doura; Ryunosuke Hata; Hiroshi Nonaka; Kazuhiro Ichikawa; Shinsuke Sando
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed
      • Design of Chemical Shift-Switching F-19 Magnetic Resonance Imaging Probe for Specific Detection of Human Monoamine Oxidase A
        Koya Yamaguchi; Ryosuke Ueki; Hiroshi Nonaka; Fuminori Sugihara; Tetsuya Matsuda; Shinsuke Sando
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2011, Peer-reviewed
      • Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts
        Hangxiang Wang; Yoichiro Koshi; Daishiro Minato; Hiroshi Nonaka; Shigeld Kiyonaka; Yasuo Mori; Shinya Tsukiji; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed
      • In situ analysis of [8-C-13-7-N-15]-double-labelled theophylline by a triple resonance NMR technique
        Koya Yamaguchi; Ryosuke Ueki; Hisatsugu Yamada; Yasuhiro Aoyama; Hiroshi Nonaka; Shinsuke Sando
        ANALYTICAL METHODS, Jul. 2011, Peer-reviewed
      • Rigid Luminescent Bis-Zinc(II)-Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution
        Mouchumi Bhuyan; Evgeny Katayev; Stefan Stadlbauer; Hiroshi Nonaka; Akio Ojida; Itaru Hamachi; Burkhard Koenig
        EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, May 2011
      • Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis
        Hiroshi Nonaka; Sho-hei Fujishima; Sho-hei Uchinomiya; Akio Ojida; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2010, Peer-reviewed
      • Binuclear Ni-II-DpaTyr Complex as a High Affinity Probe for an Oligo-Aspartate Tag Tethered to Proteins
        Akio Ojida; Sho-hei Fujishima; Kei Honda; Hiroshi Nonaka; Sho-hei Uchinomiya; Itaru Hamachi
        CHEMISTRY-AN ASIAN JOURNAL, 2010, Peer-reviewed
      • FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction
        Hiroshi Nonaka; Sho-hei Fujishima; Sho-hei Uchinomiya; Akio Ojida; Itaru Hamachi
        BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Dec. 2009, Peer-reviewed
      • Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(II)-NTA probe
        Sho-hei Uchinomiya; Hiroshi Nonaka; Sho-hei Fujishima; Shinya Tsukiji; Akio Ojida; Itaru Hamachi
        CHEMICAL COMMUNICATIONS, 2009, Peer-reviewed
      • Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene Zn-II-Dpa Chemosensor
        Takahiro Kohira; Ippei Takashima; Hiroshi Nonaka; Akio Ojida; Itaru Hamachi
        CHEMISTRY LETTERS, Nov. 2008
      • Turn-on fluorescence sensing of nucleoside polyphosphates using a xanthene-based Zn(II) complex chemosensor
        Akio Ojida; Ippei Takashima; Takahiro Kohira; Hiroshi Nonaka; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2008, Peer-reviewed
      • Non-enzymatic covalent protein labeling using a reactive tag
        Hiroshi Nonaka; Shinya Tsukiji; Akio Ojida; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2007, Peer-reviewed
      • Bis(Dpa-Zn-II) appended xanthone: Excitation ratiometric chemosensor for phosphate anions
        Akio Ojida; Hiroshi Nonaka; Yoshifumi Miyahara; Shun-ichi Tamaru; Kazuki Sada; Itaru Hamachi
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

      Misc.

      • Development of a Protein Labeling Method Using Small Molecular Probes
        OJIDA Akio; NONAKA Hiroshi; HAMACHI Itaru
        Bioscience & industry, 01 May 2010
      • 生体内 β-ガラクトシダーゼ活性検出に向けた高感度-核磁気共鳴分子プローブの検討
        近藤 洋平; 坂本 大地; 野中 洋; 高草木 洋一; 山本 和俊; Murali C Krishna; 青木 伊知男; 山東 信介
        第 14 回 日本分子イメージング学会総会・学術集会, May 2019, Peer-reviewed
      • APN 活性イメージングを目指した CEST MRI 分子プローブの設計
        森田峻平; 近藤洋平; 野中洋; 高草木洋一; 青木伊知男; 山東信介
        第 13 回 日本分子イメージング学会総会・学術集会, Jun. 2018
      • β-ガラクトシダーゼ活性の検出を指向した化学交換飽和移動を用いる核磁気共鳴分子プローブの検討
        近藤洋平; 野中洋; 高草木洋一; 青木伊知男; 山東信介
        第 13 回 日本分子イメージング学会総会・学術集会, Jun. 2018
      • Application of a novel 13C hyperpolarized metabolic tracer for gamma-Glutamyl transferase activity in vivo tumor xenograft
        Tomohiro Seki; Marino Itoda; Shun Kishimoto; Kazu Yamamoto; Yoichi Takakusagi; Jeffery Brender; Ronja M. Malinowski; Tatsuya Nishihara; Hikari A.I. Yoshihara; Hiroshi Nonaka; Keita Saito; Nobu Oshima; Jan H. Ardenkjær-Larsen; James B. Mitchell; Murali C. Krishna; Shinsuke Sando
        International Society for Magnetic Resonance in Medicine (ISMRM) 2018, Jun. 2018, Peer-reviewed
      • Exploration of molecular structures having a long hyperpolarization lifetime and its application for highly sensitive magnetic resonance probe
        Hiroshi Nonaka; Ryunosuke Hata; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012
      • Development of Ca2+ indicator for hyperpolarized C-13 MRI
        Yutaka Kameyama; Hiroshi Nonaka; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012
      • Magnetic resonance probe for selective detection of neurological disorder-related enzyme
        Ryosuke Ueki; Hiroshi Nonaka; Shinsuke Sando
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012
      • Mouse lactate dehydrogenase X: A new magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative
        Tatsuya Nishihara; Hiroshi Nonaka; Tatsuya Naganuma; Kazuhiro Ichikawa; Shinsuke Sando
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012
      • Selective protein labeling using reactive-tag system
        Hiroshi Nonaka; Shohei Uchinomiya; Shohei Fujishima; Akio Ojida; Itaru Hamachi
        ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

      External funds: Kakenhi

      • Development of molecular probes for metabolic reaction analysis at specific environmental sites in vivo
        Grant-in-Aid for Challenging Research (Exploratory)
        The University of Tokyo
        Hiroshi Nonaka
        From 30 Jun. 2017, To 31 Mar. 2019, Project Closed
        人工代謝物;分子プローブ;代謝;分析化学
      • Development of a highly sensitive detection method using hyperpolarized nuclear magnetic resonance and meso-spaces
        Grant-in-Aid for Challenging Exploratory Research
        The University of Tokyo
        Hiroshi Nonaka
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        核磁気共鳴;核偏極;分子プローブ
      • Development of hyperpolarized molecular probes toward in vivo redox analysis
        Grant-in-Aid for Challenging Exploratory Research
        The University of Tokyo;Kyushu University
        Hiroshi NONAKA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        核磁気共鳴;核偏極;酸化還元;分子プローブ;核超偏極
      • development of functional nucleic acids toward fluorescense imaging of chemical transmitter dynamics
        Grant-in-Aid for Young Scientists (B)
        Kyushu University
        Hiroshi NONAKA
        From 01 Apr. 2011, To 31 Mar. 2013, Project Closed
        核酸;アプタマー;伝達物質;イメージング;機能性核酸;細胞間情報伝達物質;アデニンヌクレオチド;センサー;蛍光イメージング
      • Development of organic chemistry targeting biomolecules in live animals
        Grant-in-Aid for Specially Promoted Research
        Science and Engineering
        Kyoto University
        浜地 格
        From 01 Apr. 2023, To 31 Mar. 2028, Granted
        分子夾雑;生命化学;脳内有機化学;リガンド指向性化学;ケミカルバイオロジー
      • 生きたマウス脳内でのミクログリア選択的化学修飾法の開発と近傍環境解析への応用
        Grant-in-Aid for Scientific Research (B)
        Basic Section 37010:Bio-related chemistry
        Kyoto University
        野中 洋
        From 01 Apr. 2024, To 31 Mar. 2027, Adopted

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