Basic Information

Concurrent Affiliation

• Center for iPS Cell Research and Application (CiRA), iPS細胞研究所 増殖分化機構研究部門, 准教授

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

ID,URL

• J-Global ID

  201401089995727454

researchmap URL

• https://researchmap.jp/7000008886

Research

Research Topics, Overview of the research

• Research Topics

  Toward clinical applications of cardiomyocytes and hematopoietic cells derived from pluripotent stem cells

• Overview of the research

  Our lab is using iPS cells to study cardiomyocytes and blood cells with application towards regenerative medicine, drug discovery and disease modeling.
  1. Development of myocardial regenerative medicine.
  2. Disease modeling using iPS cells.
  3. Efficient generation and maturation of cardiomyocytes and blood cells for clinical application.
  4. Investigation into mechanisms determining the differentiation capacity of ES/iPS cells.

Research Areas

• Life sciences, Cardiology

Papers

• SMAD3 mediates the specification of human induced pluripotent stem cell-derived epicardium into progenitors for the cardiac pericyte lineage

  Yutaro Miyoshi; Antonio Lucena-Cacace; Yu Tian; Yasuko Matsumura; Kanae Tani; Misato Nishikawa; Megumi Narita; Takeshi Kimura; Koh Ono; Yoshinori Yoshida

  Stem Cell Reports, Sep. 2024

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• Generation of 3D-Multicellular Human iPSC-Heart Organoids for the Noninvasive Assessment of Cardiac Fibrosis

  Antonio Lucena-Cacace; Yu Tian; Yoshinori Yoshida

  Methods in Molecular Biology, 28 Apr. 2024

  
• Modelling and drug targeting of a myeloid neoplasm with atypical 3q26/MECOM rearrangement using patient-specific iPSCs.

  Momoko Nakamura; Kazuhisa Chonabayashi; Megumi Narita; Yasuko Matsumura; Misato Nishikawa; Yotaro Ochi; Yasuhito Nannya; Masakatsu Hishizawa; Daichi Inoue; Ruud Delwel; Seishi Ogawa; Akifumi Takaori-Kondo; Yoshinori Yoshida

  British journal of haematology, 26 Aug. 2024

  
• Resistance of KIR Ligand–Missing Leukocytes to NK Cells in Vivo in Patients with Acquired Aplastic Anemia

  Thi Nguyen, M.A.; Hosokawa, K.; Yoroidaka, T.; Maruyama, H.; Espinoza, J.L.; Elbadry, M.I.; Mohiuddin, M.; Tanabe, M.; Katagiri, T.; Nakagawa, N.; Chonabayashi, K.; Yoshida, Y.; Arima, N.; Kashiwase, K.; Saji, H.; Ogawa, S.; Nakao, S.

  Brazilian Business Review, 2021

  
• DDX41の病的バリアントと体細胞変異の機能的差異

  中村 桃子; 蝶名林 和久; 丹羽 諒; Woltjen Knut; 越智 陽太郎; 南谷 泰仁; 小川 誠司; 高折 晃史; 吉田 善紀

  日本血液学会学術集会, Oct. 2023

  
• ロングリードシークエンスを用いたder(1;7)(q10;p10)を伴う骨髄異形成症候群における染色体切断点の検索

  須川 正啓; 奥田 瑠璃花; 越智 陽太郎; 南谷 泰仁; 中村 航; Mateos Raul; 飯田 直子; 千葉 健一; 岡田 愛; 木村 啓佑; 辻村 太郎; 蝶名林 和久; 山本 拓也; 吉田 善紀; 高折 晃史; 加藤 元博; 小川 誠司; 白石 友一

  日本血液学会学術集会, Oct. 2023

  
• TAD boundary deletion causes PITX2-related cardiac electrical and structural defects

  Manon Baudic; Hiroshige Murata; Fernanda M. Bosada; Uirá Souto Melo; Takanori Aizawa; Pierre Lindenbaum; Lieve E. van der Maarel; Amaury Guedon; Estelle Baron; Enora Fremy; Adrien Foucal; Taisuke Ishikawa; Hiroya Ushinohama; Sean J. Jurgens; Seung Hoan Choi; Florence Kyndt; Solena Le Scouarnec; Vincent Wakker; Aurélie Thollet; Annabelle Rajalu; Tadashi Takaki; Seiko Ohno; Wataru Shimizu; Minoru Horie; Takeshi Kimura; Patrick T. Ellinor; Florence Petit; Yves Dulac; Paul Bru; Anne Boland; Jean-François Deleuze; Richard Redon; Hervé Le Marec; Thierry Le Tourneau; Jean-Baptiste Gourraud; Yoshinori Yoshida; Naomasa Makita; Claude Vieyres; Takeru Makiyama; Stephan Mundlos; Vincent M. Christoffels; Vincent Probst; Jean-Jacques Schott; Julien Barc

  Nature Communications, 20 Apr. 2024

  
• Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression

  D. Otero-Albiol; J. M. Santos-Pereira; A. Lucena-Cacace; C. Clemente-González; S. Muñoz-Galvan; Y. Yoshida; A. Carnero

  Cell Death & Disease, 28 Feb. 2024

  
• CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells.

  Misato Nakanishi-Koakutsu; Kenji Miki; Yuki Naka; Masako Sasaki; Takayuki Wakimizu; Stephanie C Napier; Chikako Okubo; Megumi Narita; Misato Nishikawa; Reo Hata; Kazuhisa Chonabayashi; Akitsu Hotta; Kenichi Imahashi; Tomoyuki Nishimoto; Yoshinori Yoshida

  Communications biology, 28 Feb. 2024

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• ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation.

  Yuya Fujiwara; Kenji Miki; Kohei Deguchi; Yuki Naka; Masako Sasaki; Ayaka Sakoda; Megumi Narita; Sachiko Imaichi; Tsukasa Sugo; Shunsuke Funakoshi; Tomoyuki Nishimoto; Kenichi Imahashi; Yoshinori Yoshida

  Stem cell reports, 21 Sep. 2023

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• Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart.

  Manabu Kasamoto; Shunsuke Funakoshi; Takeshi Hatani; Chikako Okubo; Yohei Nishi; Yuta Tsujisaka; Misato Nishikawa; Megumi Narita; Akira Ohta; Takeshi Kimura; Yoshinori Yoshida

  Stem cell reports, 27 Jun. 2023

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• Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

  Jingshan Gao; Takeru Makiyama; Yuta Yamamoto; Takuya Kobayashi; Hisaaki Aoki; Thomas L Maurissen; Yimin Wuriyanghai; Asami Kashiwa; Tomohiko Imamura; Takanori Aizawa; Hai Huang; Hirohiko Kohjitani; Misato Nishikawa; Kazuhisa Chonabayashi; Megumi Fukuyama; Hiromi Manabe; Kouichi Nakau; Tsutomu Wada; Koichi Kato; Futoshi Toyoda; Yoshinori Yoshida; Naomasa Makita; Knut Woltjen; Seiko Ohno; Nagomi Kurebayashi; Takashi Murayama; Takashi Sakurai; Minoru Horie; Takeshi Kimura

  Circulation. Arrhythmia and electrophysiology, Mar. 2023

  
• Immunosuppressants Tacrolimus and Sirolimus revert the cardiac antifibrotic properties of p38-MAPK inhibition in 3D-multicellular human iPSC-heart organoids.

  Yu Tian; Yuta Tsujisaka; Vanessa Y Li; Kanae Tani; Antonio Lucena-Cacace; Yoshinori Yoshida

  Frontiers in cell and developmental biology, 2022

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• ヒトES/iPS細胞由来心筋細胞を用いた催不整脈作用検出とその課題

  澤田光平; 松尾純子; 長田智治; 吉田善紀; 白尾智明; 佐藤薫; 諫田泰成; 関野祐子

  心電図, 20 Dec. 2014

  
• オリゴヌクレオチドを用いたcalmodulinopathyに対する治療法の開発(Development of an Oligonucleotide-Based Therapeutic Approach for Calmodulinopathy)

  Makiyama Takeru; Yamamoto Yuta; Kondoh Yoshiki; Gao Jingshan; Kashiwa Asami; Aizawa Takanori; Imamura Tomohiko; Huang Hai; Kohjitani Hirohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Makita Naomasa; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• 遺伝性不整脈に対するオーダーメイド医療の現在の概観 iPS細胞を用いたリアノジン受容体遺伝子異常による遺伝性不整脈のモデリング(Current Perspective on Precision Medicine of Inherited Arrhythmias Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells)

  Makiyama Takeru; Gao Jingshan; Yamamoto Yuta; Kashiwa Asami; Aizawa Takanori; Imamura Tomohiko; Huang Hai; Kohjitani Hirohiko; Kato Kouichi; Ishikawa Taisuke; Aoki Hisaaki; Toyoda Futoshi; Wolten Knut; Yoshida Yoshinori; Ohno Seiko; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• QT延長症候群に関連するCALM2-N98S変異はヒトiPSC由来心筋細胞におけるβ-アドレナリン刺激に対するKCNQ1チャネルの応答を損なう(CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes)

  Yamamoto Yuta; Makiyama Takeru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Gao Jingshan; Kashiwa Asami; Huang Hai; Aizawa Takanori; Imamura Tomohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• LMNA関連心筋症に特異的なiPS細胞由来の心筋細胞にアドレナリン作動性刺激を負荷すると、分化早期に加齢関連表現型を繰り返す(LMNA-Related Cardiomyopathy Specific Induced-Pluripotent Stem Cells-derived Cardiomyocytes Stressed by Adrenergic Stimulation Recapitulate the Aging-Related Phenotype in an Early-Phase of Differentiation)

  Nishiuchi Suguru; Makiyama Takeru; Sasaki Kenichi; Kohjitani Hirohiko; Yimin Wuriyanghai; Yamamoto Yuta; Harita Takeshi; Hayano Mamoru; Kamakura Tsukasa; Ohno Seiko; Yoshida Yoshinori; Doi Takahiro; Shizuta Satoshi; Aiba Takeshi; Horie Minoru; Kimura Takeshi

  Circulation Journal, Mar. 2015

  
• Disrupted Cav1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C-E1115K iPS cell model.

  Asami Kashiwa; Takeru Makiyama; Hirohiko Kohjitani; Thomas L Maurissen; Taisuke Ishikawa; Yuta Yamamoto; Yimin Wuriyanghai; Jingshan Gao; Hai Huang; Tomohiko Imamura; Takanori Aizawa; Misato Nishikawa; Kazuhisa Chonabayashi; Hiroyuki Mishima; Seiko Ohno; Futoshi Toyoda; Seiichi Sato; Koh-Ichiro Yoshiura; Kazuhiro Takahashi; Yoshinori Yoshida; Knut Woltjen; Minoru Horie; Naomasa Makita; Takeshi Kimura

  Heart rhythm, 23 Aug. 2022

  
• Hematopoietic stem progenitor cells with malignancy-related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4.

  Takamasa Katagiri; Jorge Luis Espinoza; Mizuho Uemori; Honoka Ikeda; Kohei Hosokawa; Ken Ishiyama; Takeshi Yoroidaka; Tatsuya Imi; Hiroyuki Takamatsu; Tatsuhiko Ozawa; Hiroyuki Kishi; Yasuhiko Yamamoto; Mahmoud Ibrahim Elbadry; Yoshinori Yoshida; Kazuhisa Chonabayashi; Katsuto Takenaka; Koichi Akashi; Yasuhito Nannya; Seishi Ogawa; Shinji Nakao

  EJHaem, Aug. 2022

  
• CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells.

  Julia Junghof; Yuta Kogure; Tian Yu; Eva María Verdugo-Sivianes; Megumi Narita; Antonio Lucena-Cacace; Yoshinori Yoshida

  NPJ Regenerative medicine, 02 Feb. 2022

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• A versatile and robust cell purification system with an RNA-only circuit composed of microRNA-responsive ON and OFF switches.

  Yoshihiko Fujita; Moe Hirosawa; Karin Hayashi; Takeshi Hatani; Yoshinori Yoshida; Takuya Yamamoto; Hirohide Saito

  Science advances, 07 Jan. 2022

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• Recent progress of iPSC technology in cardiac diseases.

  Shunsuke Funakoshi; Yoshinori Yoshida

  Archives of toxicology, Dec. 2021

  
• Making Cardiomyocytes from Pluripotent Stem Cells.

  Peter Karagiannis; Yoshinori Yoshida

  Methods in molecular biology (Clifton, N.J.), 2021

  
• Efficient Method to Dissociate Induced Pluripotent Stem Cell-Derived Cardiomyocyte Aggregates into Single Cells.

  Emiko Ito; Shigeru Miyagawa; Yoshinori Yoshida; Yoshiki Sawa

  Methods in molecular biology (Clifton, N.J.), 2021

  
• Application of FluoVolt Membrane Potential Dye for Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Differentiated via Embryoid Bodies.

  Tadashi Takaki; Yoshinori Yoshida

  Methods in molecular biology (Clifton, N.J.), 2021

  
• RNA-Sequencing Analysis of Differentially Expressed Genes in Human iPSC-Derived Cardiomyocytes.

  Chikako Okubo; Megumi Narita; Takuya Yamamoto; Yoshinori Yoshida

  Methods in molecular biology (Clifton, N.J.), 2021

  
• Analysis of Transcriptional Profiling of Chamber-Specific Human Cardiac Myocytes Derived from Pluripotent Stem Cells.

  Antonio Lucena-Cacace; Yoshinori Yoshida

  Methods in molecular biology (Clifton, N.J.), 2021

  
• Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Mouse Myocardial Infarction Model.

  Takeshi Hatani; Yoshinori Yoshida

  Methods in molecular biology (Clifton, N.J.), 2021

  
• Erratum: Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack (Blood Adv) (2018) 2:4 (390-400) DOI: 10.1182/bloodadvances.201701334)

  Espinoza, J.L.; Elbadry, M.I.; Chonabayashi, K.; Yoshida, Y.; Katagiri, T.; Harada, K.; Nakagawa, N.; Zaimoku, Y.; Imi, T.; Takamatsu, H.; Ozawa, T.; Maruyama, H.; Hassanein, H.A.; Noreldin, A.K.A.; Takenaka, K.; Akashi, K.; Hamana, H.; Kishi, H.; Akatsuka, Y.; Nakao, S.

  Blood Advances, 2018, Peer-reviewed

  
• 5Fr.ステロイド溶出カラー付き心房screw-in leadの有用性について

  山田 貴之; 貝谷 和昭; 静田 聡; 酒井 孝裕; 安藤 献児; 西山 慶; 白井 伸一; 土井 孝浩; 吉田 善紀; 中川 義久; 延吉 正清

  不整脈, Apr. 2002

  
• たこつぼ型心筋症(心筋障害)を検証する たこつぼ型心筋症の臨床経過と長期予後 冠動脈造影,左室造影からの検証

  吉田 善紀; 木村 剛; 静田 聡; 貝谷 和昭; 岩淵 成志; 中川 義久; 横井 宏佳; 浜崎 直也; 野坂 秀之; 井上 勝美

  日本心臓核医学会ニュースレター, Mar. 2002

  
• Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting.

  Yuta Tsujisaka; Takeshi Hatani; Chikako Okubo; Ryo Ito; Azuma Kimura; Megumi Narita; Kazuhisa Chonabayashi; Shunsuke Funakoshi; Antonio Lucena-Cacace; Taro Toyoda; Kenji Osafune; Takeshi Kimura; Hirohide Saito; Yoshinori Yoshida

  Stem cell reports, 12 Jul. 2022

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• Azacitidine is a potential therapeutic drug for pyridoxine-refractory female X-linked sideroblastic anemia

  Yuki Morimoto; Kazuhisa Chonabayashi; Hiroshi Kawabata; Chikako Okubo; Makiko Yamasaki-Morita; Misato Nishikawa; Megumi Narita; Azusa Inagaki; Kayoko Nakanishi; Miki Nagao; Akifumi Takaori-Kondo; Yoshinori Yoshida

  Blood Advances, 22 Feb. 2022

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• Elucidating the pathophysiology of AML with atypical 3q26 translocations using patient-derived iPSCs(和訳中)

  中村 桃子; 蝶名林 和久; 森本 有紀; 越智 陽太郎; 南谷 泰仁; 北脇 年雄; 菱澤 方勝; 小川 誠司; 高折 晃史; 吉田 善紀

  日本血液学会学術集会, Sep. 2021

  
• The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-β.

  Mikoto Tanabe; Kohei Hosokawa; Mai Anh Thi Nguyen; Noriharu Nakagawa; Kana Maruyama; Noriaki Tsuji; Ryota Urushihara; Luis Espinoza; Mahmoud I Elbadry; Md Mohiuddin; Takamasa Katagiri; Masanori Ono; Hiroshi Fujiwara; Kazuhisa Chonabayashi; Yoshinori Yoshida; Hirohito Yamazaki; Atsushi Hirao; Shinji Nakao

  Leukemia, 06 Nov. 2021

  
• ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

  Kenji Miki; Kohei Deguchi; Misato Nakanishi-Koakutsu; Antonio Lucena-Cacace; Shigeru Kondo; Yuya Fujiwara; Takeshi Hatani; Masako Sasaki; Yuki Naka; Chikako Okubo; Megumi Narita; Ikue Takei; Stephanie C. Napier; Tsukasa Sugo; Sachiko Imaichi; Taku Monjo; Tatsuya Ando; Norihisa Tamura; Kenichi Imahashi; Tomoyuki Nishimoto; Yoshinori Yoshida

  Nature Communications, Dec. 2021

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• Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation.

  Chikako Okubo; Megumi Narita; Azusa Inagaki; Misato Nishikawa; Akitsu Hotta; Shinya Yamanaka; Yoshinori Yoshida

  Stem cell reports, 10 Aug. 2021

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• Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy.

  Minas Nalbandian; Mingming Zhao; Mitsuru Sasaki-Honda; Tatsuya Jonouchi; Antonio Lucena-Cacace; Takuma Mizusawa; Masahiko Yasuda; Yoshinori Yoshida; Akitsu Hotta; Hidetoshi Sakurai

  Stem cell reports, 13 Apr. 2021

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• Overview of the 84th Annual Scientific Meeting of the Japanese Circulation Society - Change Practice!

  Koh Ono; Satoshi Shizuta; Erika Yamamoto; Naritatsu Saito; Neiko Ozasa; Takao Kato; Eri Kato; Takahiro Horie; Junichi Tazaki; Hiroki Shiomi; Shin Watanabe; Hirotoshi Watanabe; Yugo Yamashita; Yusuke Yoshikawa; Hideyuki Kinoshita; Takeru Makiyama; Yoshinori Yoshida; Noboru Ashida; Yasuaki Nakagawa; Yasuhiro Nakashima; Osamu Baba; Hirohiko Kohjitani; Masahiro Kimura; Hideaki Inazumi; Takashi Yoshizawa; Akihiro Komasa; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 25 Feb. 2021

  
• of Derived from Human Pluripotent Stem Using

  Kenji Miki; Hirohide Saito; Yoshinori Yoshida

  Methods in Molecular Biology, 2021

  
• Characterization of Ventricular and Atrial Subtypes from Human-

  Misato Nakanishi-Koakutsu; Tadashi Takaki; Kenji Miki; Yoshinori Yoshida

  Methods in Molecular Biology, 2021

  
• A Method for Contraction Force Measurement of hiPSC-Derived Engineered

  Yuya Fujiwara; Kohei Deguchi; Kenji Miki; Tomoyuki Nishimoto; Yoshinori Yoshida

  Methods in Molecular Biology, 2021

  
• Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload.

  Yasuhide Kuwabara; Shuhei Tsuji; Masataka Nishiga; Masayasu Izuhara; Shinji Ito; Kazuya Nagao; Takahiro Horie; Shin Watanabe; Satoshi Koyama; Hisanori Kiryu; Yasuhiro Nakashima; Osamu Baba; Tetsushi Nakao; Tomohiro Nishino; Naoya Sowa; Yui Miyasaka; Takeshi Hatani; Yuya Ide; Fumiko Nakazeki; Masahiro Kimura; Yoshinori Yoshida; Tsukasa Inada; Takeshi Kimura; Koh Ono

  Communications biology, 13 Aug. 2020

  
• Resistance of KIR Ligand-Missing Leukocytes to NK Cells In Vivo in Patients with Acquired Aplastic Anemia.

  Mai Anh Thi Nguyen; Kohei Hosokawa; Takeshi Yoroidaka; Hiroyuki Maruyama; J Luis Espinoza; Mahmoud I Elbadry; Md Mohiuddin; Mikoto Tanabe; Takamasa Katagiri; Noriharu Nakagawa; Kazuhisa Chonabayashi; Yoshinori Yoshida; Nobuyoshi Arima; Koichi Kashiwase; Hiroh Saji; Seishi Ogawa; Shinji Nakao

  ImmunoHorizons, 17 Jul. 2020, Peer-reviewed

  
• CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes(和訳中)

  Yamamoto Yuta; Makiyama Takeru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Gao Jingshan; Kashiwa Asami; Huang Hai; Aizawa Takanori; Imamura Tomohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.

  Hiroki Mizumaki; Kazuyoshi Hosomichi; Kohei Hosokawa; Takeshi Yoroidaka; Tatsuya Imi; Yoshitaka Zaimoku; Takamasa Katagiri; Mai Anh Thi Nguyen; Dung Cao Tran; Mahmoud Ibrahim Yousef Elbadry; Kazuhisa Chonabayashi; Yoshinori Yoshida; Hiroyuki Takamatsu; Tatsuhiko Ozawa; Fumihiro Azuma; Hiroyuki Kishi; Yoichi Fujii; Seishi Ogawa; Atsushi Tajima; Shinji Nakao

  Haematologica, 21 May 2020, Peer-reviewed

  
• Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model.

  Sayako Hirose; Takeru Makiyama; Dario Melgari; Yuta Yamamoto; Yimin Wuriyanghai; Fumika Yokoi; Suguru Nishiuchi; Takeshi Harita; Mamoru Hayano; Hirohiko Kohjitani; Jingshan Gao; Asami Kashiwa; Misato Nishikawa; Jie Wu; Jun Yoshimoto; Kazuhisa Chonabayashi; Seiko Ohno; Yoshinori Yoshida; Minoru Horie; Takeshi Kimura

  Frontiers in cell and developmental biology, 2020

  
• Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish.

  Ryuji Okamoto; Itaru Goto; Yuhei Nishimura; Issei Kobayashi; Ryotaro Hashizume; Yoshinori Yoshida; Rie Ito; Yuhko Kobayashi; Misato Nishikawa; Yusuf Ali; Shunsuke Saito; Toshio Tanaka; Yoshiki Sawa; Masaaki Ito; Kaoru Dohi

  PloS one, 2020

  
• Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells.

  Hiroyuki Fukushima; Miki Yoshioka; Masahide Kawatou; Víctor López-Dávila; Masafumi Takeda; Yasunari Kanda; Yuko Sekino; Yoshinori Yoshida; Jun K Yamashita

  PloS one, 2020

  
• Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis.

  Kazuhisa Chonabayashi; Yoshinori Yoshida; Toshio Kitawaki; Yasuhito Nannya; Momoko Nakamura; Shinichiro Oshima; Masakatsu Hishizawa; Kouhei Yamashita; Seishi Ogawa; Akifumi Takaori-Kondo

  Annals of hematology, Dec. 2019, Peer-reviewed

  
• Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.

  Mahmoud I Elbadry; Hiroki Mizumaki; Kohei Hosokawa; J Luis Espinoza; Noriharu Nakagawa; Kazuhisa Chonabayashi; Yoshinori Yoshida; Takamasa Katagiri; Kazuyoshi Hosomichi; Yoshitaka Zaimoku; Tatsuya Imi; Mai Anh Thi Nguyen; Youichi Fujii; Atsushi Tajima; Seishi Ogawa; Katsuto Takenaka; Koichi Akashi; Shinji Nakao

  Haematologica, Oct. 2019, Peer-reviewed

  
• Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.

  Joseph C Wu; Priyanka Garg; Yoshinori Yoshida; Shinya Yamanaka; Lior Gepstein; Jean-Sébastien Hulot; Björn C Knollmann; Peter J Schwartz

  Circulation research, 30 Aug. 2019, Peer-reviewed

  
• Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility.

  Huaigeng Xu; Bo Wang; Miyuki Ono; Akihiro Kagita; Kaho Fujii; Noriko Sasakawa; Tatsuki Ueda; Peter Gee; Misato Nishikawa; Masaki Nomura; Fumiyo Kitaoka; Tomoko Takahashi; Keisuke Okita; Yoshinori Yoshida; Shin Kaneko; Akitsu Hotta

  Cell stem cell, 04 Apr. 2019, Peer-reviewed

  
• Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients.

  Tadashi Takaki; Azusa Inagaki; Kazuhisa Chonabayashi; Keiji Inoue; Kenji Miki; Seiko Ohno; Takeru Makiyama; Minoru Horie; Yoshinori Yoshida

  Stem cells international, 2019, Peer-reviewed

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• Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.

  Karagiannis P; Takahashi K; Saito M; Yoshida Y; Okita K; Watanabe A; Inoue H; Yamashita JK; Todani M; Nakagawa M; Osawa M; Yashiro Y; Yamanaka S; Osafune K

  Physiological reviews, Jan. 2019, Peer-reviewed

  
• Nano-structural analysis of engrafted human induced pluripotent stem cell-derived cardiomyocytes in mouse hearts using a genetic-probe APEX2.

  Hatani T; Funakoshi S; Deerinck TJ; Bushong EA; Kimura T; Takeshima H; Ellisman MH; Hoshijima M; Yoshida Y

  Biochemical and biophysical research communications, Nov. 2018, Peer-reviewed

  
• Complex aberrant splicing in the induced pluripotent stem cell-derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation.

  Yimin Wuriyanghai; Takeru Makiyama; Kenichi Sasaki; Tsukasa Kamakura; Yuta Yamamoto; Mamoru Hayano; Takeshi Harita; Suguru Nishiuchi; Jiarong Chen; Hirohiko Kohjitani; Sayako Hirose; Fumika Yokoi; Jingshan Gao; Kazuhisa Chonabayashi; Ken Watanabe; Seiko Ohno; Yoshinori Yoshida; Takeshi Kimura; Minoru Horie

  Heart rhythm, Oct. 2018, Peer-reviewed

  
• QT延長症候群3型の患者特異的幹細胞モデルにおいてpropranololにより遅延ナトリウム電流が減弱する(Propranolol Attenuates Late Sodium Current in Patient-specific Stem Cell Model of Long-QT Syndrome Type 3)

  Hirose Sayako; Makiyama Takeru; Melgari Dario; Wu Jie; Yokoi Fumika; Wuriyanghai Yimin; Yamamoto Yuta; Kohjitani Hirohiko; Nishiuchi Suguru; Harita Takeshi; Hayano Mamoru; Yoshimoto Jun; Ohno Seiko; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2018

  
• Lamin A/C関連心筋症の病態生理学的メカニズム分析のためのホモ接合性Lamin A/C欠損ヒト人工多能性幹細胞モデルの開発(Development of Homozygous LaminA/C Deficient Human Induced Pluripotent Stem Cell Model for Analyzing the Pathophysiological Mechanism of Lamin A/C-related Cardiomyopathy)

  Wuriyanghai Yimin; Makiyama Takeru; Nishiuchi Suguru; Yamamoto Yuta; Hirose Sayako; Hayano Mamoru; Harita Takeshi; Kohjitani Hirohiko; Yokoi Fumika; Chonabayashi Kazuhisa; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2018

  
• CALM2-D134H変異を有するQT延長症候群のヒトiPS細胞モデルではL型Ca2+チャネル不活性化がみられなかった(The Inactivation of L-type Ca2+ Cannel was Impaired in Human iPS Cell Model of Long-QT Syndrome with CALM2-D134H Mutation)

  Yamamoto Yuta; Makiyama Takeru; Harita Takeshi; Hayano Mamoru; Nishiuchi Suguru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Yokoi Fumika; Ishikawa Taisuke; Ohno Seiko; Chonabayashi Kazuhisa; Suda Kenji; Yoshida Yoshinori; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2018

  
• Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack.

  Espinoza JL; Elbadry MI; Chonabayashi K; Yoshida Y; Katagiri T; Harada K; Nakagawa N; Zaimoku Y; Imi T; Hassanein HA; Khalifa A Noreldin A; Takenaka K; Akashi K; Hamana H; Kishi H; Akatsuka Y; Nakao S

  Blood Advances, Feb. 2018, Peer-reviewed

  
• Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82

  Masafumi Takeda; Yasuharu Kanki; Hidetoshi Masumoto; Shunsuke Funakoshi; Takeshi Hatani; Hiroyuki Fukushima; Akashi Izumi-Taguchi; Yusuke Matsui; Teppei Shimamura; Yoshinori Yoshida; Jun K. Yamashita

  Cell Reports, 2018, Peer-reviewed

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• Induction of Human Induced Pluripotent Stem Cells to Cardiomyocytes Using Embryoid Bodies.

  Hatani T; Miki K; Yoshida Y

  Methods in molecular biology (Clifton, N.J.), 2018, Peer-reviewed

  
• Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy

  Mamoru Hayano; Takeru Makiyama; Tsukasa Kamakura; Hiroshi Watanabe; Kenichi Sasaki; Shunsuke Funakoshi; Yimin Wuriyanghai; Suguru Nishiuchi; Takeshi Harita; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Fumika Yokoi; Jiarong Chen; Osamu Baba; Takahiro Horie; Kazuhisa Chonabayashi; Seiko Ohno; Futoshi Toyoda; Yoshinori Yoshida; Koh Ono; Minoru Horie; Takeshi Kimura

  CIRCULATION JOURNAL, Dec. 2017, Peer-reviewed

  
• 【iPS細胞技術を駆使したがん、感染症のあらたな制御】 疾患iPS細胞 血液疾患の病態解明への応用

  吉田 善紀

  医学のあゆみ, Dec. 2017

  
• iPS細胞と血液分化

  梅田 雅之; 吉田 善紀

  臨床免疫・アレルギー科, Sep. 2017

  
• Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model.

  Masashi Kawamura; Shigeru Miyagawa; Satsuki Fukushima; Atsuhiro Saito; Kenji Miki; Shunsuke Funakoshi; Yoshinori Yoshida; Shinya Yamanaka; Tatsuya Shimizu; Teruo Okano; Takashi Daimon; Koichi Toda; Yoshiki Sawa

  Scientific reports, 18 Aug. 2017, Peer-reviewed

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• Induced Pluripotent Stem Cells 10 Years Later For Cardiac Applications

  Yoshinori Yoshida; Shinya Yamanaka

  CIRCULATION RESEARCH, Jun. 2017, Peer-reviewed, Invited

  
• Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides

  Yi Kuang; Kenji Miki; Callum J. C. Parr; Karin Hayashi; Ikue Takei; Jie Li; Mio Iwasaki; Masato Nakagawa; Yoshinori Yoshida; Hirohide Saito

  CELL CHEMICAL BIOLOGY, Jun. 2017, Peer-reviewed

  
• Monitoring and visualizing microRNA dynamics during live cell differentiation using microRNA-responsive non-viral reporter vectors

  Hideyuki Nakanishi; Kenji Miki; Kaoru R. Komatsu; Masayuki Umeda; Megumi Mochizuki; Azusa Inagaki; Yoshinori Yoshida; Hirohide Saito

  BIOMATERIALS, Jun. 2017, Peer-reviewed

  
• Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation

  Yuta Yamamoto; Takeru Makiyama; Takeshi Harita; Kenichi Sasaki; Yimin Wuriyanghai; Mamoru Hayano; Suguru Nishiuchi; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Fumika Yokoi; Taisuke Ishikawa; Seiko Ohno; Kazuhisa Chonabayashi; Hideki Motomura; Yoshinori Yoshida; Minoru Horie; Naomasa Makita; Takeshi Kimura

  HUMAN MOLECULAR GENETICS, May 2017, Peer-reviewed

  
• 【日常化するシングルセル遺伝子発現解析】 心筋分化過程を描写するシングルセル遺伝子発現解析

  中村 正裕; 吉田 善紀; 渡辺 亮

  細胞, May 2017

  
• L型Ca2+チャネル遺伝子変異によるQT延長症候群iPS細胞モデルにおいて、l-cis-DiltiazemはCaチャネル不活性化を改善した(l-cis-diltiazem rescues impaired calcium channel inactivation in an iPSC-model of CACNA1Cassociated long-QT syndrome)

  Harita Takeshi; Makiyama Takeru; Toyoda Futoshi; Sasaki Kenichi; Nishiuchi Suguru; Hayano Mamoru; Yamamoto Yuta; Kohjitani Hirohiko; Wuriyanghai Yimin; Hirose Sayako; Chen Jiarong; Fukuyama Megumi; Chonabayashi Kazuhisa; Ohno Seiko; Yoshida Yoshinori; Ueyama Takeshi; Shimizu Akihiko; Matsuura Hiroshi; Horie Minoru; Kimura Takeshi

  The Journal of Physiological Sciences, Mar. 2017

  
• Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability

  Junko Ueki; Masayuki Nakamori; Masahiro Nakamura; Misato Nishikawa; Yoshinori Yoshida; Azusa Tanaka; Asuka Morizane; Masayoshi Kamon; Toshiyuki Araki; Masanori P. Takahashi; Akira Watanabe; Nobuya Inagaki; Hidetoshi Sakurai

  SCIENTIFIC REPORTS, Feb. 2017, Peer-reviewed

  
• Reprogramming technology reveals genetic and functional diversity of subclones in myelodysplastic syndromes.

  Chonabayashi K; Yoshida Y; Takaori-Kondo A

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2017, Peer-reviewed

  
• Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia

  Kenichi Sasaki; Takeru Makiyama; Yoshinori Yoshida; Yimin Wuriyanghai; Tsukasa Kamakura; Suguru Nishiuchi; Mamoru Hayano; Takeshi Harita; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Mihoko Kawamura; Seiko Ohno; Hideki Itoh; Ayako Takeuchi; Satoshi Matsuoka; Masaru Miura; Naokata Sumitomo; Minoru Horie; Shinya Yamanaka; Takeshi Kimura

  PLOS ONE, Oct. 2016, Peer-reviewed

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• MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells

  Callum J. C. Parr; Shota Katayama; Kenji Miki; Yi Kuang; Yoshinori Yoshida; Asuka Morizane; Jun Takahashi; Shinya Yamanaka; Hirohide Saito

  SCIENTIFIC REPORTS, Sep. 2016, Peer-reviewed

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• Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity

  Masatoshi Nishizawa; Kazuhisa Chonabayashi; Masaki Nomura; Azusa Tanaka; Masahiro Nakamura; Azusa Inagaki; Misato Nishikawa; Ikue Takei; Akiko Oishi; Koji Tanabe; Mari Ohnuki; Hidaka Yokota; Michiyo Koyanagi-Aoi; Keisuke Okita; Akira Watanabe; Akifumi Takaori-Kondo; Shinya Yamanaka; Yoshinori Yoshida

  CELL STEM CELL, Sep. 2016, Peer-reviewed

  
• Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives

  Fabian Oceguera-Yanez; Shin-Il Kim; Tomoko Matsumoto; Ghee Wan Tan; Long Xiang; Takeshi Hatani; Takayuki Kondo; Makoto Ikeya; Yoshinori Yoshida; Haruhisa Inoue; Knut Woltjen

  METHODS, May 2016, Peer-reviewed

  
• Lamin A/C関連心筋症特異的人工多能性幹細胞由来心筋細胞における心臓イオンチャネル関連遺伝子の異常発現(Abnormal Expressions of Cardiac Ion Channels-associated Genes in Lamin A/C-related Cardiomyopathy-specific Induced Pluripotent Stem Cell-derived Cardiomyocytes)

  Nishiuchi Suguru; Makiyama Takeru; Sasaki Kenichi; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Yamamoto Yuta; Harita Takeshi; Hayano Mamoru; Ohno Seiko; Shizuta Satoshi; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  Circulation Journal, Mar. 2016

  
• SCN5A-D1275N変異を保有する患者特異的なヒト人工多能性幹細胞由来心筋細胞の電気生理学的特徴(Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation)

  Hayano Mamoru; Makiyama Takeru; Sasaki Kenichi; Kamakura Tsukasa; Wuriyanghai Yimin; Chen Jiarong; Nishiuchi Suguru; Harita Takeshi; Yamamoto Yuta; Kohjitani Hirohiko; Hirose Sayako; Ohno Seiko; Toyoda Futoshi; Watanabe Hiroshi; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  Circulation Journal, Mar. 2016

  
• Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

  Takuji Kawamura; Shigeru Miyagawa; Satsuki Fukushima; Akira Maeda; Noriyuki Kashiyama; Ai Kawamura; Kenji Miki; Keisuke Okita; Yoshinori Yoshida; Takashi Shiina; Kazumasa Ogasawara; Shuji Miyagawa; Koichi Toda; Hiroomi Okuyama; Yoshiki Sawa

  STEM CELL REPORTS, Mar. 2016, Peer-reviewed

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• Sall1 transiently marks undifferentiated heart precursors and regulates their fate

  Yuika Morita; Peter Andersen; Akitsu Hotta; Yuko Tsukahara; Noriko Sasagawa; Naoko Hayashida; Chizuko Koga; Misato Nishikawa; Yumiko Saga; Sylvia M. Evans; Kazuko Koshiba-Takeuchi; Ryuichi Nishinakamura; Yoshinori Yoshida; Chulan Kwon; Jun K. Takeuchi

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Mar. 2016, Peer-reviewed

  
• 【再生医学と血管】 iPS細胞を用いた血管再生研究の展望と課題

  吉田 善紀

  血管医学, Mar. 2016

  
• Understanding Intracellular Signaling Advances Cardiac Reprogramming Technology Toward Clinical Applications

  Yoshinori Yoshida; Shinya Yamanaka

  CIRCULATION RESEARCH, Feb. 2016, Peer-reviewed, Invited

  
• Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes

  Shunsuke Funakoshi; Kenji Miki; Tadashi Takaki; Chikako Okubo; Takeshi Hatani; Kazuhisa Chonabayashi; Misato Nishikawa; Ikue Takei; Akiko Oishi; Megumi Narita; Masahiko Hoshijima; Takeshi Kimura; Shinya Yamanaka; Yoshinori Yoshida

  SCIENTIFIC REPORTS, Jan. 2016, Peer-reviewed

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• 心臓運命をプログラムする因子とその発展性

  森田 唯加; 堀田 秋津; Andersen Peter; 小川 英知; 吉田 善紀; 塚原 由布子; 黒川 洵子; 相賀 裕美子; Evans Sylvia; 西中村 隆一; 小柴 和子; Kwon Chulan; 竹内 純

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Peer-reviewed

  
• 日本のパイオニア 日本で開発された細胞 iPS細胞

  舟越 俊介; 山中 伸弥; 吉田 善紀

  循環器専門医, Sep. 2015

  
• Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches

  Kenji Miki; Kei Endo; Seiya Takahashi; Shunsuke Funakoshi; Ikue Takei; Shota Katayama; Taro Toyoda; Maki Kotaka; Tadashi Takaki; Masayuki Umeda; Chikako Okubo; Misato Nishikawa; Akiko Oishi; Megumi Narita; Ito Miyashita; Kanako Asano; Karin Hayashi; Kenji Osafune; Shinya Yamanaka; Hirohide Saito; Yoshinori Yoshida

  CELL STEM CELL, Jun. 2015, Peer-reviewed

  
• 【iPS細胞を用いた難病研究-臨床病態解明と創薬に向けた研究の最新知見】 (第4章)血液・免疫疾患 リプログラミング技術を用いた骨髄異形成症候群の病態解明と新規治療の可能性

  蝶名林 和久; 吉田 善紀; 高折 晃史

  遺伝子医学MOOK, Feb. 2015

  
• 【シングルセル生物学】 幹細胞・発生研究におけるシングルセル遺伝子発現解析

  中村 正裕; 野村 真樹; 溝曽路 祥孝; 吉田 善紀; 渡辺 亮

  実験医学, Jan. 2015

  
• 【循環器疾患と再生医療】 ES細胞とiPS細胞

  吉田 善紀

  心臓, Dec. 2014

  
• Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells

  Kazuaki Tokunaga; Noriko Saitoh; Ilya G. Goldberg; Chiyomi Sakamoto; Yoko Yasuda; Yoshinori Yoshida; Shinya Yamanaka; Mitsuyoshi Nakao

  SCIENTIFIC REPORTS, Nov. 2014, Peer-reviewed

  
• 【医学・医療のいまがわかるキーワード2014】 再生医学 iPS細胞

  吉田 善紀; 山中 伸弥

  医学のあゆみ, May 2014

  
• A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

  Masato Nakagawa; Yukimasa Taniguchi; Sho Senda; Nanako Takizawa; Tomoko Ichisaka; Kanako Asano; Asuka Morizane; Daisuke Doi; Jun Takahashi; Masatoshi Nishizawa; Yoshinori Yoshida; Taro Toyoda; Kenji Osafune; Kiyotoshi Sekiguchi; Shinya Yamanaka

  SCIENTIFIC REPORTS, Jan. 2014, Peer-reviewed

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• Making Steady Progress on Direct Cardiac Reprogramming Toward Clinical Application

  Kenji Miki; Yoshinori Yoshida; Shinya Yamanaka

  CIRCULATION RESEARCH, Jun. 2013, Peer-reviewed, Invited

  
• Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture

  Tsukasa Kamakura; Takeru Makiyama; Kenichi Sasaki; Yoshinori Yoshida; Yimin Wuriyanghai; Jiarong Chen; Tetsuhisa Hattori; Seiko Ohno; Toru Kita; Minoru Horie; Shinya Yamanaka; Takeshi Kimura

  CIRCULATION JOURNAL, May 2013, Peer-reviewed

  
• An Emerging Strategy of Gene Therapy for Cardiac Disease

  Yoshinori Yoshida; Shinya Yamanaka

  CIRCULATION RESEARCH, Oct. 2012, Peer-reviewed, Invited

  
• Labor pains of new technology: direct cardiac reprogramming.

  Y. Yoshida; S. Yamanaka

  Circulation research, Jun. 2012, Peer-reviewed, Invited

  
• iPS細胞を用いた遺伝性心疾患の分子病態の解明と創薬研究

  吉田善紀

  遺伝子医学MOOK 22: 133-136, 2012, Peer-reviewed, Invited

  
• iPS cells: A source of cardiac regeneration

  Yoshinori Yoshida; Shinya Yamanaka

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Feb. 2011, Peer-reviewed, Invited

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• Recent Stem Cell Advances: Induced Pluripotent Stem Cells for Disease Modeling and Stem Cell-Based Regeneration

  Yoshinori Yoshida; Shinya Yamanaka

  CIRCULATION, Jul. 2010, Peer-reviewed, Invited

  
• The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5 gene targeting

  Yasuhiro Nakashima; Koh Ono; Yoshinori Yoshida; Yoji Kojima; Toru Kita; Makoto Tanaka; Takeshi Kimura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2009, Peer-reviewed

  
• Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

  Yoshinori Yoshida; Kazutoshi Takahashi; Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka

  CELL STEM CELL, Sep. 2009, Peer-reviewed

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• Progranulin expression in advanced human atherosclerotic plaque

  Yoji Kojima; Koh Ono; Katsumi Inoue; Yasushi Takagi; Ken-ichiro Kikuta; Masaki Nishimura; Yoshinori Yoshida; Yasuhiro Nakashima; Hironobu Matsumae; Yutaka Furukawa; Nobuhiro Mikuni; Masakiyo Nobuyoshi; Takeshi Kimura; Toru Kita; Makoto Tanaka

  ATHEROSCLEROSIS, Sep. 2009, Peer-reviewed

  
• CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model

  Hironobu Matsumae; Yoshinori Yoshida; Koh Ono; Kiyonori Togi; Katsumi Inoue; Yutaka Furukawa; Yasuhiro Nakashima; Yoji Kojima; Masakiyo Nobuyoshi; Toru Kita; Makoto Tanaka

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jun. 2008, Peer-reviewed

  
• CCN1 protects cardiac myocytes from oxidative stress via beta 1 integrin-Akt pathway

  Yoshinori Yoshida; Kiyonori Togi; Hironobu Matsumae; Yasuhiro Nakashima; Yoji Kojima; Hiromi Yamamoto; Koh Ono; Tomoyuki Nakamura; Toru Kita; Makoto Tanaka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2007, Peer-reviewed

  
• Endothelin-1 activates Homer 1a expression via mitogen-activated protein kinase in cardiac myocytes

  T Kawamoto; K Togi; R Yamauchi; Y Yoshida; Y Nakashima; T Kita; M Tanaka

  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Jul. 2006, Peer-reviewed

  
• Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development

  K Togi; Y Yoshida; H Matsumae; Y Nakashima; T Kita; M Tanaka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2006, Peer-reviewed

  
• Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart

  K Togi; T Kawamoto; R Yamauchi; Y Yoshida; T Kita; M Tanaka

  MOLECULAR AND CELLULAR BIOLOGY, Jun. 2004, Peer-reviewed

  
• Long-term (three-year) outcomes after stenting of unprotected left main coronary artery stenosis in patients with normal left ventricular function

  SJ Park; SW Park; MK Hong; CW Lee; JH Lee; JJ Kim; YS Jang; EK Shin; Y Yoshida; T Tamura; T Kimura; M Nobuyoshi

  AMERICAN JOURNAL OF CARDIOLOGY, Jan. 2003, Peer-reviewed

  
• Long-term clinical and angiographic follow-up after coronary stent placement in native coronary arteries

  T Kimura; K Abe; S Shizuta; K Odashiro; Y Yoshida; K Sakai; K Kaitani; K Inoue; Y Nakagawa; H Yokoi; M Iwabuchi; N Hamasaki; H Nosaka; M Nobuyoshi

  CIRCULATION, Jun. 2002, Peer-reviewed

  
• Complications of Percutaneous Coronary Intervention : From 1984 to 1998 at Kokura Memorial Hospital

  NOSAKA Hideyuki; SHIRAI Sinichi; KIMURA Takeshi; HAMASAKI Naoya; NAKAGAWA Yoshihisa; YOKOI Hiroyoshi; IWABUCHI Seishi; KAITANI Kazuaki; SAKAI Takahiro; SHIZUTA Satoshi; ANDO Kenji; NISHIYAMA Kei; YAMADA Takayuki; DOI Takahiro; HATA Yoshiki; ODASHIRO Keita; HIRAMATSU Shinichi; ANDO Jiro; TAMURA Toshihiro; SAKAMOTO Keishi; YOSHIDA Yoshinori; INOUE Katsumi; NOBUYOSHI Masakiyo

  Japanese journal of cardiovascular catheter therapeutics = 日本心血管カテーテル治療学会誌 : JACCT, 01 Sep. 2001

  

Misc.

• Hypertrophic stimuli induce association of mineralocorticoid receptor with a transcriptional coactivator p300 in cardiac myocytes

  T Kawamura; K Ono; T Morimoto; Y Yoshida; Y Abe; N Sowa; K Hasegawa

  CIRCULATION, Oct. 2004

  
• Nuclear acetylation of GATA-4 as well as of histone is involved in the differentiation of emryonic stem cells into cardiac myocytes

  T Kawamura; K Hasegawa; M Hirai; Y Yoshida; H Wada; T Morimoto; K Hidaka; T Morisaki; T Heike; T Nakahata; T Kita

  CIRCULATION, Oct. 2003

  
• Novel CPVT-Associated Calmodulin Mutation Activating RyR2 Channels Causes Robust Arrhythmogenicity in iPS Cell Model

  GAO Jingshan; MAKIYAMA Takeru; YAMAMOTO Yuta; KOBAYASHI Takuya; AOKI Hisaaki; MAURISSEN L Thomas; KASHIWA Asami; IMAMURA Tomohiko; AIZAWA Takanori; HUANG Hai; KOHJITANI Hirohiko; KATO Koichi; YOSHIDA Yoshinori; MAKITA Naomasa; WOLTJEN Knut; OHNO Seiko; KUREBAYASHI Nagomi; MURAYAMA Takashi; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2022

  
• Antisense-Mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy

  YAMAMOTO Yuta; MAKIYAMA Takeru; KONDO Yoshiki; IRIYAMA Yusuke; WURIYANGHAI Yimin; KOHJITANI Hirohiko; GAO Jingshan; KASHIWA Asami; HUANG Hai; AIZAWA Takanori; IMAMURA Tomohiko; ISHIKAWA Taisuke; YOSHIDA Yoshinori; OHNO Seiko; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2021

  
• Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells

  MAKIYAMA Takeru; GAO Jingshan; YAMAMOTO Yuta; KASHIWA Asami; AIZAWA Takanori; IMAMURA Tomohiko; HUANG Hai; KOHJITANI Hirohiko; KATO Kouichi; ISHIKAWA Taisuke; AOKI Hisaaki; TOYODA Futoshi; WOLTEN Knut; YOSHIDA Yoshinori; OHNO Seiko; MAKITA Naomasa; KIMURA Takeshi

  日本循環器学会学術集会(Web), 2021

  
• Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System

  YAMAMOTO Yuta; MAKIYAMA Takeru; WURIYANGHAI Yimin; KOHJITANI Hirohiko; HIROSE Sayako; GAO Jingshan; KASHIWA Asami; HUANG Hai; ISHIKAWA Taisuke; OHNO Seiko; CHONABAYASHI Kazuhisa; SUDA Kenji; YOSHIDA Yoshinori; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2019

  
• Impaired response of KCNQ1 channel to beta-adrenergic stimulation in human iPSC-derived cardiomyocytes carrying a CALM2-N98S mutation associated with long QT syndrome

  YAMAMOTO Yuta; MAKIYAMA Takeru; WURIYANGHAI Yimin; KOHJITANI Hirohiko; HIROSE Sayako; GAO Jingshan; KASHIWA Asami; HAI Huang; AIZAWA Takanori; IMAMURA Tomohiko; ISHIKAWA Taisuke; MOTOMURA Hideki; YOSHIDA Yoshinori; OHNO Seiko; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  Journal of Arrhythmia (Web), 2019

  
• ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes

  奥田瑠璃花; 南谷泰人; 越智陽太郎; 蝶名林和久; 蝶名林和久; 牧島秀樹; 吉里哲一; 永田安伸; 竹田淳恵; 吉田健一; 眞田昌; 眞田昌; 昆彩奈; 白石雄一; 宮野悟; 熱田由子; 笠原千嗣; 半田寛; 千葉滋; 大屋敷一馬; 吉田善紀; 小川誠司; 小川誠司; 小川誠司

  日本血液学会学術集会抄録(Web), 2021

  
• Der(1;7) 陽性骨髄異形成症候群における人種,臨床像,遺伝学的観点からみた特徴

  奥田瑠璃花; 南谷泰仁; 越智陽太郎; 蝶名林和久; 蝶名林和久; 牧島秀樹; 吉里哲一; 永田安伸; 竹田淳恵; 吉田健一; 真田昌; 真田昌; 昆彩奈; 白石友一; 宮野悟; 宮野悟; KERN Wolfgang; BAER Constance; NADARAJAH Niroshan; ALPERMANN Tamara; HAFERLACH Claudia; 熱田由子; 笠原千嗣; 半田寛; 千葉滋; 大屋敷一馬; HAFERLACH Torsten; 吉田善紀; 小川誠司; 小川誠司; 小川誠司

  日本血液学会学術集会抄録(Web), 2020

  
• 心筋細胞移植を目的としたiPS細胞の心筋細胞分化誘導および経皮的カテーテルデバイスを用いた心筋細胞投与方法の開発研究

  齋藤 成達; 吉田 善紀; 川瀬 世史明

  福田記念医療技術振興財団情報, Dec. 2012

  
• Inhibition of Aldosterone Suppresses PDGF-and Basic FGF-Induced Proliferative Change in Vascular Smooth Muscle Cells

  Yoshida Yoshinori; Hasegawa Koji; Abe Mitsuru; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

  
• Inhibition of Cardiac Aldosterone System by Spironolactone Blocks Gq Protein Coupled Agonist-Induced Hypertrophic Responses in Cardiac Myocytes

  Yoshida Yoshinori; Hasegawa Koji; Abe Mitsuru; Kihara Yasuki; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

  
• PROGRANULIN IN ADVANCED HUMAN ATHEROSCLEROTIC PLAQUE

  Yoji Kojima; Koh Ono; Katsumi Inoue; Yasushi Takagi; Ken-Ichiro Kikuta; Masaki Nishimura; Yoshinori Yoshida; Yasuhiro Nakashima; Hironobu Matsumae; Yutaka Furukawa; Nobuhiro Mikuni; Masakiyo Nobuyoshi; Takeshi Kimura; Toru Kita; Makoto Tanaka

  JOURNAL OF VASCULAR RESEARCH, 2009

  
• PE-533 CCN1 Protects Cardiac Myocytes from Oxidative Stress via β 1 Integrin-Akt Pathway(Molecular biology, myocardium-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Yoshida Yoshinori; Tanaka Makoto; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• 19) ロータブレーターの初期及び遠隔成績,時代区分による検討

  吉田 善紀; 横井 宏佳; 斉藤 仁知; 静田 聡; 酒井 孝裕; 貝谷 和昭; 阿部 健一; 小田代 敬太; 田村 崇; 岩淵 成志; 中川 義久; 濱崎 直也; 木村 剛; 野坂 秀行; 延吉 正清

  Japanese circulation journal, 20 Oct. 2000

  
• Long-term outcomes after unprotected left main coronay artery stenting

  Yoshida Yoshinori; Kimura Takeshi; Shirai Shinichi; Yokoi Hiroyoshi; Nakagawa Yoshihisa; Iwabuchi Masashi; Hamasaki Naoya; Inoue Katsumi; Nosaka Hideyuki; Nobuyoshi Masakiyo; Tamura Takashi

  Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002

  
• Role of Embryonic Epicardial Cells in Cardiomyocyte Proliferation and Coronary Vessel Formation during Cardiac Development(Cardiovascular Development, The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Tanaka Makoto; Yoshida Yoshinori; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• 140) 右室心尖部ペーシングから両室ペーシングにstep-upすることによりIABPから離脱し得た拡張型心筋症の一例(第96回日本循環器学会近畿地方会)

  牛呂 幸司; 静田 聡; 土井 孝裕; 田村 俊寛; 斉藤 成達; 吉田 善紀; 神原 直樹; 大庭 宗夫; 細川 了平; 当麻 正直; 古川 裕; 佐藤 幸人; 木村 剛; 北 徹

  Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2004

  
• Elucidating the pathophysiology of AML with atypical 3q26 translocations using patient-derived iPSCs

  中村桃子; 中村桃子; 蝶名林和久; 蝶名林和久; 森本有紀; 森本有紀; 越智陽太郎; 越智陽太郎; 南谷泰仁; 北脇年雄; 菱澤方勝; 菱澤方勝; 小川誠司; 高折晃史; 吉田善紀

  日本血液学会学術集会抄録(Web), 2021

  
• OE-392 Progranulin Expression in Advanced Human Atherosclerotic Plaque(OE66,Atherosclerosis (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Kojima Yoji; Ono Koh; Inoue Katsumi; Yoshida Yoshinori; Nakashima Yasuhiro; Matsumae Hironobu; Furukawa Yutaka; Nobuyoshi Masakiyo; Kimura Takeshi; Kita Toru; Tanaka Makoto

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• KCNQ1 Channel Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated With Long QT Syndrome

  Yuta Yamamoto; Takeru M. Makiyama; Yimin Wuriyanghai; Hirohiko Kohjitani; Sayako Hirose; Jingshan Gao; Asami Kashiwa; Huang Hai; Takanori Aizawa; Tomohiko Imamura; Taisuke Ishikawa; Seiko Ohno; Kazuhisa Chonabayashi; Hideki Motomura; Yoshinori Yoshida; Minoru Horie; Naomasa Makita; Takeshi Kimura

  CIRCULATION, Nov. 2019

  
• Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

  Kohei Hosokawa; Mahmoud Ibrahim Elbadry; Hiroki Mizumaki; Luis Espinoza; Noriharu Nakagawa; Kazuhisa Chonabayashi; Yoshinori Yoshida; Takamasa Katagiri; Yoshitaka Zaimoku; Tatsuya Imi; Nguyen Thi Mai Anh; Yoichi Fujii; Seishi Ogawa; Katsuto Takenaka; Koichi Akashi; Shinji Nakao

  BLOOD, Nov. 2018

  
• 疾患iPS細胞を用いたX連鎖性鉄芽球性貧血の病態解明(Modeling X-linked sideroblastic anemia with patient-derived human induced pluripotent stem cells)

  森本 有紀; 蝶名林 和久; 川端 浩; 高折 晃史; 吉田 善紀

  臨床血液, Sep. 2018

  
• CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める(l-cis-Diltiazem Enhances Slowed L-type Calcium Channel Inactivation in CALM2-associated Long-QT Syndrome iPSC Model)

  横井 文香; 牧山 武; 山本 雄大; 張田 健志; Wuriyanghai Yimin; 早野 護; 西内 英; 糀谷 泰彦; 廣瀬 紗也子; 高 景山; 大野 聖子; 豊田 太; 吉田 善紀; 蒔田 直昌; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2018

  
• SCN5A-D1275N関連性心筋ナトリウムチャネロパチーのヒトiPSC由来心筋細胞モデルから、蛋白質分解の亢進によってナトリウム電流が低下することが判明した(Human iPSC-Derived Myocyte Model of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting from Enhanced Protein Degradation)

  早野 護; 牧山 武; 鎌倉 令; 渡部 裕; 伊敏 烏日揚海; 西内 英; 張田 健志; 山本 雄大; 糀谷 泰彦; 廣瀬 紗也子; 横井 文香; 大野 聖子; 豊田 太; 吉田 善紀; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2018

  
• CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める(l-cis-Diltiazem Enhances Slowed L-type Calcium Channel Inactivation in CALM2-associated Long-QT Syndrome iPSC Model)

  横井 文香; 牧山 武; 山本 雄大; 張田 健志; Wuriyanghai Yimin; 早野 護; 西内 英; 糀谷 泰彦; 廣瀬 紗也子; 高 景山; 大野 聖子; 豊田 太; 吉田 善紀; 蒔田 直昌; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2018

  
• SCN5A-D1275N関連性心筋ナトリウムチャネロパチーのヒトiPSC由来心筋細胞モデルから、蛋白質分解の亢進によってナトリウム電流が低下することが判明した(Human iPSC-Derived Myocyte Model of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting from Enhanced Protein Degradation)

  早野 護; 牧山 武; 鎌倉 令; 渡部 裕; 伊敏 烏日揚海; 西内 英; 張田 健志; 山本 雄大; 糀谷 泰彦; 廣瀬 紗也子; 横井 文香; 大野 聖子; 豊田 太; 吉田 善紀; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2018

  
• リプログラミング技術を用いた骨髄異形成症候群の腫瘍内遺伝的・機能的多様性の解明

  蝶名林 和久; 吉田 善紀; 高折 晃史

  臨床血液, Jul. 2017

  
• I-cis-diltiazem rescues impaired calcium channel inactivation in an iPSC-model of CACNA1C-associated long-QT syndrome

  HARITA Takeshi; MAKIYAMA Takeru; TOYODA Futoshi; SASAKI Kenichi; NISHIUCHI Suguru; HAYANO Mamoru; YAMAMOTO Yuta; KOHJITANI Hirohiko; WURIYANGHAI Yimin; HIROSE Sayako; CHEN Jiarong; FUKUYAMA Megumi; CHONABAYASHI Kazuhisa; OHNO Seiko; YOSHIDA Yoshinori; UEYAMA Takeshi; SHIMIZU Akihiko; MATSUURA Hiroshi; HORIE Minoru; KIMURA Takeshi

  Journal of Physiological Sciences, 2017

  
• Modelling Long-QT Syndrome Type 3 Associated with Near-Miss Sudden Infant Death Syndrome Using Human-Induced Pluripotent Stem Cells

  HIROSE Sayako; MAKIYAMA Takeru; MELGARI Dario; WU Jie; WU Jie; YOKOI Fumika; WURIYANGHAI Yimin; KOHJITANI Hirohiko; YAMAMOTO Yuta; NISHIUCHI Suguru; HAYANO Mamoru; HARITA Takeshi; YOSHIMOTO Jun; OHNO Seiko; YOSHIDA Yoshinori; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2017

  
• lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation

  YOKOI Fumika; MAKIYAMA Takeru; HARITA Takeshi; YAMAMOTO Yuta; HAYANO Mamoru; NISHIUCHI Suguru; KOHJITANI Hirohiko; WURIYANGHAI Yimin; WURIYANGHAI Yimin; HIROSE Sayako; TOYODA Futoshi; YOSHIDA Yoshinori; MAKITA Naomasa; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2017

  
• Ips Technology Revealed the Genetic and Functional Diversity Present in a Secondary AML Patient

  Kazuhisa Chonabayashi; Masahiro Kawahara; Akira Watanabe; Masahiro Nakamura; Masatoshi Nishizawa; Akifumi Takaori-Kondo; Shinya Yamanaka; Yoshinori Yoshida

  BLOOD, Dec. 2016

  
• T-tubules and Dyad Formation in Engrafted iPSC-Derived Cardiomyocytes With Stable APEX2 Expression

  Takeshi Hatani; Shunsuke Funakoshi; Thomas J. Deerinck; Eric A. Bushong; Takeshi Kimura; Shinya Yamanaka; Mark H. Ellisman; Masahiko Hoshijima; Yoshinori Yoshida

  CIRCULATION, Nov. 2016

  
• Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation

  HAYANO Mamoru; MAKIYAMA Takeru; SASAKI Kenichi; KAMAKURA Tsukasa; WURIYANGHAI Yimin; CHEN Jiarong; NISHIUCHI Suguru; HARITA Takeshi; YAMAMOTO Yuta; KOHJITANI Hirohiko; HIROSE Sayako; OHNO Seiko; TOYODA Futoshi; WATANABE Hiroshi; YOSHIDA Yoshinori; HORIE Minoru; KIMURA Takeshi

  Circulation Journal, 2016

  
• The Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Long QT Syndrome Type 8 Patients without Extracardiac Phenotypes

  HARITA Takeshi; MAKIYAMA Takeru; SASAKI Kenichi; NISHIUCHI Suguru; HAYANO Mamoru; YAMAMOTO Yuta; KOHJITANI Hirohiko; HIROSE Sayako; JIARONG Chen; WURIYANGHAI Yimin; FUKUYAMA Megumi; TOYODA Futoshi; OHNO Seiko; YOSHIDA Yoshinori; UEYAMA Takeshi; SHIMIZU Akihiko; HORIE Minoru; KIMURA Takeshi

  Circulation Journal, 2016

  
• l-cis Diltiazem Rescues Impaired Calcium Channel Inactivation in a Patient-specific Stem Cell Model of Long QT Syndrome with a CACNA1C Mutation

  HARITA Takeshi; MAKIYAMA Takeru; TOYODA Futoshi; SASAKI Kenichi; NISHIUCHI Suguru; HAYANO Mamoru; YAMAMOTO Yuta; KOHJITANI Hirohiko; WURIYANGHAI Yimin; HIROSE Sayako; CHEN Jiarong; CHONABAYASHI Kazuhisa; OHNO Seiko; YOSHIDA Yoshinori; UEYAMA Takeshi; SHIMIZU Akihiko; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2016

  
• Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation

  HAYANO Mamoru; MAKIYAMA Takeru; SASAKI Kenichi; KAMAKURA Tsukasa; WURIYANGHAI Yimin; NISHIUCHI Suguru; HARITA Takeshi; YAMAMOTO Yuta; KOHJITANI Hirohiko; HIROSE Sayoko; OHNO Seiko; YOYODA Futoshi; WATANABE Hirohi; YOSHIDA Yoshinori; YAMANAKA Shinya; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2016

  
• CALM遺伝子変異によるQT延長症候群の患者由来iPS細胞を用いた疾患モデルにおける変異アレル特異的ノックアウトによる治療的アプローチ

  山本雄大; 牧山武; 張田健志; 佐々木健一; 早野護; 西内英; ウリヤンハイ イミン; 糀谷泰彦; 廣瀬紗也子; チン カヨウ; 石川泰輔; 大野聖子; 蝶名林和久; 吉田善紀; 堀江稔; 蒔田直昌; 木村剛

  日本分子生物学会年会プログラム・要旨集(Web), 2016

  
• Generation of Ips Cell-Derived Hematopoietic Progenitor Cells from Patients with Acquired Aplastic Anemia Harboring Copy Number Neutral Loss of Heterozygosity of the Short Arm of Chromosome 6

  Luis Espinoza; Yoshinori Yoshida; Kazuhisa Chonabayashi; Takamasa Katagiri; Yoshitaka Zaimoku; Shinji Nakao

  BLOOD, Dec. 2015

  
• Stably Expressed APEX2 Identifies the Integration of iPSC-derived Cardiomyocytes in a Mouse Model of Myocardial Infarction

  Takeshi Hatani; Shunsuke Funakoshi; Thomas J. Deerinck; Eric A. Bushong; Takeshi Kimura; Shinya Yamanaka; Mark H. Ellisman; Masahiko Hoshijima; Yoshinori Yoshida

  CIRCULATION, Nov. 2015

  
• Abnormal expression of cardiac ion channels-associated genes in lamin A/C-related cardiomyopathy-specific induced pluripotent stem cell derived cardiomyocytes

  S. Nishiuchi; T. Makiyama; K. Sasaki; Y. Kohjitani; S. Ohno; Y. Yoshida; T. Doi; S. Shizuta; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2015

  
• 臨床応用を目指した基礎研究 再生医療を目指した前臨床研究 心機能再生を目指した特定因子による細胞変換技術開発

  森田唯加; 藤川大地; 堀田秋津; 吉田善紀; 小柴和子; 竹内純

  日本臨床, Jun. 2015

  
• Electrophysiological Properties of L-type Calcium Channels in Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes

  HARITA Takeshi; MAKIYAMA Takeru; SASAKI Kenichi; HAYANO Mamoru; NISHIUCHI Suguru; YAMAMOTO Yuta; KOHJITANI Hirohiko; CHEN Jiarong; WURIYANGHAI Yimin; OHNO Seiko; ITO Hideki; YOSHIDA Yoshinori; HORIE Minoru; KIMURA Takeshi

  Circulation Journal, 2015

  
• 疾患特異的iPS細胞を活用した特発性造血障害の病態解析と新規治療法開発 骨髄異形成症候群に関わる研究開発

  蝶名林和久; 吉田善紀

  疾患特異的iPS細胞を活用した特発性造血障害の病態解析と新規治療法の開発 平成26年度 委託業務成果報告書, 2015

  
• Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Maturation Defect of Myelodysplastic Syndromes

  Kazuhisa Chonabayashi; Masahiro Kawahara; Keisuke Okita; Masatoshi Nishizawa; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Shinya Yamanaka; Yoshinori Yoshida

  BLOOD, Dec. 2014

  
• Single Cell RNA Sequencing Reveals Dynamic and Heterogeneous Changes of Transcriptome During Cardiac Differentiation in vitro

  Shunsuke Funakoshi; Masaki Nomura; Chikako Okubo; Kenji Miki; Takeshi Kimura; Shinya Yamanaka; Akira Watanabe; Yoshinori Yoshida

  CIRCULATION, Nov. 2014

  
• Very High Engraftment, Proliferation, and Therapeutic Potential of IPSC-Derived Cardiomycytes

  Shunsuke Funakoshi; Kenji Miki; Takeshi Kimura; Shinya Yamanaka; Yoshinori Yoshida

  CIRCULATION, Nov. 2014

  
• A Novel Purification Method for Cardiomyocytes and Endothelial Cells Derived From Human Pluripotent Stem Cells Using Micrornaresponsive Messenger Rna

  Kenji Miki; Seiya Takahashi; Shunsuke Funakoshi; Shinya Yamanaka; Hirohide Saito; Yoshinori Yoshida

  CIRCULATION, Nov. 2014

  
• Recapitulation of lamin A/C-related cardiomyopathy using patient-specific induced pluripotent stem cells: a novel splicing mutation in LMNA gene

  S. Nishiuchi; T. Makiyama; K. Sasaki; Y. Wuriyanghai; Y. Yoshida; S. Ono; T. Aiba; W. Shimizu; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Novel abnormal splicing variants identified in induced pluripotent stem cell-derived cardiomyocytes from a long-QT syndrome patient with KCNQ1-A344A

  Y. Wuriyanghai; T. Makiyama; K. Sasaki; Y. Yoshida; S. Ohno; K. Watanabe; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• iPS technology revealed the genetic and functional diversity present in a single MDS patient

  Chonabayashi K; Kawahara M; Watanabe A; Amano N; Okita K; Nishizawa M; Kadowaki N; Takaori-Kondo A; Yamanaka S; Yoshida Y

  臨床血液, Sep. 2014

  
• 致死性不整脈症候群の病態解明に関する研究―臨床・基礎研究(ヒト疾患特異的人工多能性幹(iPS)細胞を用いた解析)

  木村剛; 北徹; 堀江稔; 堀内久徳; 尾野亘; 牧山武; 吉田善紀

  医科学応用研究財団研究報告(CD-ROM), Feb. 2014

  
• 致死性不整脈症候群の病態解明に関する研究 臨床・基礎研究(ヒト疾患特異的人工多能性幹(iPS)細胞を用いた解析)

  木村 剛; 北 徹; 堀江 稔; 堀内 久徳; 尾野 亘; 牧山 武; 吉田 善紀

  医科学応用研究財団研究報告, Feb. 2014

  
• Search for pathogenesis of acquired myelodysplastic syndromes using reprogramming technology

  Chonabayashi K; Kawahara M; Watanabe A; Okita K; Nishizawa M; Kadowaki N; Takaori-Kondo A; Yamanaka S; Yoshida Y

  第75回日本血液学会学術集会, Oct. 2013

  
• iPS細胞由来の不整脈疾患モデル心筋細胞

  牧山武; 佐々木健一; 鎌倉令; 吉田善紀; 堀江稔; 木村剛

  心電図, 11 Sep. 2013

  
• One-year assessment of ultrastructural changes in human induced pluripotent stem cell-derived cardiomyocytes

  T. Kamakura; T. Makiyama; K. Sasaki; T. Hattori; S. Ohno; Y. Yoshida; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2012

  
• Labor Pains of New Technology Direct Cardiac Reprogramming

  Yoshinori Yoshida; Shinya Yamanaka

  CIRCULATION RESEARCH, Jun. 2012

  
• Analysis of differentiation capacity toward cardiomyocytes from pluripotent stem cells.

  Yoshida, Y; Oishi, A; Nishikawa, M; Takei, I; Okita, K; Yamanaka, S

  ISSCR 10th annual Meeting, Jun. 2012, Peer-reviewed

  
• Progranulin is Expressed in the Human Atherosclerotic Plaque and Reduces IL-8 Secretion from Smooth Muscle Cells, Endothelial Cells, And Macrophages

  KOJIMA Yoji; ONO Koh; INOUE Katsumi; YOSHIDA Yoshinori; NAKASHIMA Yasuhiro; NOBUYOSHI Masakiyo; KITA Toru; KIMURA Takeshi; TANAKA Makoto

  Circ J, 01 Mar. 2010, Peer-reviewed

  
• The Identification of the Nkx2-5-regulated Genes Using Purified ES Cell-derived Cardiomyocytes

  Yasuhiro Nakashima; Koh Ono; Yoshinori Yoshida; Yoji Kojima; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2009

  
• Establishment of a new method for the investigation of cardiac transcription factor

  Yasuhiro Nakashima; Yoshinori Yoshida; Yohji Kojima; Makoto Tanaka; Toru Kita

  JOURNAL OF CARDIAC FAILURE, Sep. 2008

  
• Comparison of Clinical Outcomes and Renal Function after Percutaneous Coronary Intervention in Patients with and without Impaired Renal Function

  YOSHIDA Yoshinori; SAKAMOTO Keiji; NAKAGAWA Yoshihisa; IWABUCHI Masashi; NOSAKA Hideyuki; NOBUYOSHI Masakiyo

  Japanese journal of cardiovascular catheter therapeutics = 日本心血管カテーテル治療学会誌 : JACCT, 01 Jun. 2003

  
• Long-term (3-year) outcomes after stenting of unprotected left main coronary artery stenosis in patients with normal left ventricular function: Results of multi-center study

  SJ Park; SW Park; MK Hong; CW Lee; JH Lee; JJ Kim; YS Jang; EK Shin; Y Yoshida; T Tamura; T Kimura; M Nobuyoshi

  CIRCULATION, Nov. 2002

  
• Worsening of glycemic control raises frequency receiving Percutaneous Coronary Intervention

  Doi Takahiro; Nobuyoshi Masakiyo; Nosaka Hideyuki; Inoue Katsumi; Kimura Takeshi; Hamasaki Naoya; Nakagawa Yoshihisa; Yokoi Hiroyoshi; Iwabuchi Masashi; Odashiro Keita; Abe Kenichi; Kaitani Kazuaki; Shizuta Satoshi; Shirai Shinichi; Nishiyama Kei; Andoh Kenji; Yamada Takashi; Sakamoto Keiji; Yoshida Yoshinori

  Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002

  
• Impact of End Stage Renal Disease on Outcomes After Rotational Atherectomy (Rotablator)

  Nishiyama Kei; Yoshida Yoshinori; Yokoi Hiroyoshi; Nakagawa Yoshihisa; Iwabuchi Masashi; Hamasaki Naoya; Kimura Takeshi; Inoue Katsumi; Nosaka Hideyuki; Nobuyoshi Masakiyo; Nakanishi Michio

  Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002

  
• Long-term outcomes after unprotected left main coronary artery stenting

  Y Yoshida; T Kimura; T Tamura; S Shirai; K Nishiyama; K Ando; S Shizuta; K Kaitani; M Iwabuchi; H Yokoi; Y Nakagawa; N Hamasaki; K Inoue; H Nosaka; M Nobuyoshi

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2002

  
• Predictors of In-hospital Mortality in Patients with Ventricular Fibrillation after Acute Myocardial Infarction

  ANDO Kenji; NAKAGAWA Yoshihisa; SOGA Yoshimitsu; KOMURA Yasuo; TAKAMA Noriaki; KITAMURA Ryoji; YASUE Shintaro; SAITO Naritatsu; YOSHIDA Yoshinori; SAKAMOTO Keiji; HATA Yoshiki; TAMURA Toshihiro; ANDO Jiro; YAMADA Takayuki; DOI Takahiro; SHIRAI Shinichi; NISHIYAMA Kei; HIRAMATSU Shinichi; ODASHIRO Keita; ABE Kenichi; SAKAI Koyu; SHIZUTA Satoshi; KAITANI Kazuaki; INOUE Katsumi; IWABUCHI Masashi; YOKOI Hiroyoshi; HAMASAKI Naoya; KIMURA Takeshi; NOSAKA Hideyuki; NOBUYOSHI Masakiyo

  Japanese journal of cardiovascular catheter therapeutics = 日本心血管カテーテル治療学会誌 : JACCT, 01 Sep. 2001

  
• P485 NEW DEVICE時代におけるバルーン単独療法の初期及び遠隔期成績

  坂本 圭司; 土井 孝浩; 吉田 善紀; 安藤 献児; 西山 慶; 白井 伸一; 中西 道郎; 静田 聡; 酒井 孝裕; 貝谷 和昭; 阿部 健一; 田村 崇; 岩渕 成志; 小田代 啓太; 中川 義久; 浜崎 直也; 木村 剛; 野坂 秀行; 延吉 正清

  Japanese circulation journal, 01 Mar. 2000

  
• 0005 ロタブレーターの初期および遠隔成績,時代区分による検討

  吉田 善紀; 横井 宏佳; 西山 慶; 田村 嵩; 中川 義久; 木村 剛; 野坂 秀行; 延吉 正清

  Japanese circulation journal, 01 Mar. 2000

  
• 0007 ローターブレーター施行後の血管の性状変化に対する検討

  西山 慶; 藤島 槇一郎; 横井 宏佳; 斎藤 仁知; 吉田 善紀; 田村 嵩; 岩淵 成志; 中川 義久; 濱崎 直也; 木村 剛; 野坂 秀行; 延吉 正清

  Japanese circulation journal, 01 Mar. 2000

  

External funds: Kakenhi

• 心外膜細胞の増殖分化制御メカニズムの解明とその応用技術の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Kyoto University

  吉田 善紀

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  心外膜細胞;多能性幹細胞;分化;増殖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02912/
• An integrated approach for cell cycle control of pluripotent stem cell-derived cardiomyocytes

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshinori Yoshida

  From 01 Apr. 2017, To 31 Mar. 2021, Project Closed

  細胞周期;心筋細胞;iPS細胞;細胞移植;循環器;再生医療;多能性幹細胞;再生医学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04176/
• Analysis of the mechanisms underlying clonal hematopoiesis in patients with acquired aplastic anemia

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Shinji Nakao

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  再生不良性貧血;クローン性造血;HLA;細胞傷害性T細胞;自己抗原;HLAクラスIアレル欠失;HLAクラスIアレル欠失血球;CD109;HLAクラスI欠失;6pLOH;ゲノム変異;iPS細胞;T細胞レセプター;体細胞変異;HLA欠失

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05335/
• Development of a new therapy targeting CXCR4+ hematopoietic stem cells in patients with bone marrow failure

  Grant-in-Aid for Challenging Exploratory Research

  Kanazawa University

  Nakao Shinji

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  再生不良性貧血;造血幹前駆細胞;CXCR4;BRGSマウス;iPS細胞;6pLOH;CD34陽性細胞;CXCL12;造血幹細胞;造血前駆細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15360/
• Development of a new method to induce cardiomyocytes from pluripotent stem cells in vivo for regenerative cell therapy.

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yoshinori YOSHIDA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  再生医学;iPS細胞;再生医療;心筋細胞;多能性幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790277/
• Effects of insulin resistance-related factors on the stem cell functions in vivo.

  Grant-in-Aid for Scientific Research (B)

  Shiga University of Medical Science

  Takeshi IMAMURA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  幹細胞;インスリン抵抗性因子;糖尿病;幹細胞機能;iPS細胞;再生医療;幹細胞移植;カニクイザル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390056/
• Functional analysis of CCN1 in hearts and development of new therapy for heart disease

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yoshinori YOSHIDA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  細胞外マトリックス;循環器・高血圧;再生医学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790527/
• Molecular mechanisms underlying nuclear reprogramming of somatic cells

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Kyoto University

  Shinya YAMANAKA

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  再生医学;幹細胞;分化多能性;核初期化;転写因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19002014/

Administration

Faculty management (title, position)

• From 26 May 2022, To 31 Mar. 2026

  創薬技術開発室運営委員会
• From 01 Apr. 2024, To 31 Mar. 2025

  白眉センター専門委員会
• From 01 Apr. 2020, To 31 Mar. 2022

  共通機器管理運営委員会1号委員
• エネルギー管理要員
• From 01 Apr. 2016

  安全衛生委員会1号委員、委員長
• From 23 Jan. 2020, To 31 Mar. 2025

  動物実験施設運営委員会2号委員