Basic Information

Affiliated programs (koza)

• Graduate School of Biostudies, 高次生命科学専攻 生体動態制御学, 准教授
• Graduate School of Medicine, 医学専攻 分子ウイルス学, 特定助教
• Graduate School of Medicine, 医科学専攻 分子ウイルス学, 特定助教

Academic Degree

• 博士（医学）(東京大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院医学系研究科博士課程病因・病理学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 農学部獣医学科, 卒業

High School

• High School

  愛知県立半田高等学校

Research History

• From Apr. 2024, To Present

  東京大学 国際高等研究所 新世代感染症センター, 客員准教授
• From Apr. 2022, To Present

  京都大学医生物学研究所, 准教授
• From Mar. 2018, To Present

  京都大学ウイルス・再生医科学研究所, 助教
• From Nov. 2012, To Feb. 2018

  京都大学ウイルス・再生医科学研究所, 特定助教
• From Apr. 2012, To Nov. 2012

  Kyoto University, Institute for Virus Research, 特定研究員
• From Apr. 2009, To Mar. 2012

  Kobe University, Graduate School of Medicine, GCOE研究員
• From Apr. 2006, To Mar. 2009

  日本学術振興会, 特別研究員DC1

ID,URL

• J-Global ID

  201101063743556575

• Researcher number

  30571145

researchmap URL

• https://researchmap.jp/akkmkn

Research

Research Topics, Overview of the research

• Research Topics

  ボルナウイルスベクターの応用

• Overview of the research

  持続的にタンパク質や低分子RNAを発現するボルナウイルスベクターの応用を目指し、人工的にウイルスを合成する系を用いて高力価のウイルス作製、ウイルスを効率的に産生する細胞の構築をおこなっている。

Research Areas

• Life sciences, Virology

Papers

• Distribution of lesions in psittacine birds naturally infected with parrot bornavirus in Japan

  Chinatsu FUJIWARA; Naoyuki AIHARA; Motokazu YOSHINO; Takanori SHIGA; Kan FUJINO; Ryo KOMORIZONO; Akiko MAKINO; Keizo TOMONAGA; Reiko SOGA; Junichi KAMIIE

  Journal of Veterinary Medical Science, 2024

  
• An Infection Model for SARS-CoV-2 Using Rat Transplanted with hiPSC-Airway Epithelial Cells.

  Masayuki Kitano; Hiroe Ohnishi; Akiko Makino; Tatsuo Miyamoto; Yasuyuki Hayashi; Keisuke Mizuno; Shinji Kaba; Yoshitaka Kawai; Tsuyoshi Kojima; Yo Kishimoto; Norio Yamamoto; Keizo Tomonaga; Koichi Omori

  Tissue engineering. Part A, 27 Jun. 2024

  
• A single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activity

  Yusa Akiba; Hiromichi Matsugo; Takehiro Kanda; Modoka Sakai; Akiko Makino; Keizo Tomonaga

  22 May 2024

  
• Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.

  Kozue Murata; Akiko Makino; Keizo Tomonaga; Hidetoshi Masumoto

  iScience, 19 Jan. 2024

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• Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation

  Ryo Komorizono; Kan Fujino; Susanne Kessler; Solveig Runge; Takehiro Kanda; Masayuki Horie; Akiko Makino; Dennis Rubbenstroth; Keizo Tomonaga

  Journal of Virology, 31 Aug. 2023

  
• Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection

  Junya Sunagawa; Ryo Komorizono; Hyeongki Park; William S. Hart; Robin N. Thompson; Akiko Makino; Keizo Tomonaga; Shingo Iwami; Ryo Yamaguchi

  PLOS Computational Biology, 30 May 2023

  
• Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model

  Sumio Minamiyama; Madoka Sakai; Yuko Yamaguchi; Makiko Kusui; Hideki Wada; Ryota Hikiami; Yoshitaka Tamaki; Megumi Asada-Utsugi; Akemi Shodai; Akiko Makino; Noriko Fujiwara; Takashi Ayaki; Takakuni Maki; Hitoshi Warita; Masashi Aoki; Keizo Tomonaga; Ryosuke Takahashi; Makoto Urushitani

  Molecular Therapy - Methods and Clinical Development, 09 Mar. 2023

  
• Genome-scale CRISPR‒Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection

  Madoka Sakai; Yoshie Masuda; Yusuke Tarumoto; Naoyuki Aihara; Yugo Tsunoda; Michiko Iwata; Yumiko Kamiya; Ryo Komorizono; Takeshi Noda; Kosuke Yusa; Keizo Tomonaga; Akiko Makino

  07 Mar. 2023

  
• 外来蛋白質を持続発現するボルナウイルスベクターの新たなアルツハイマー病治療戦略

  上田 紗希帆; 酒井 まどか; 大東 卓史; 浅田 めぐみ; 小松 弓子; 眞木 崇州; 葛谷 聡; 木下 彩栄; 高橋 良輔; 牧野 晶子; 朝長 啓造

  Dementia Japan, Sep. 2018

  
• Gingyo Gedokusan vs Oseltamivir for the Treatment of Uncomplicated Influenza and Influenza-like illness : An Open-label Prospective Study

  Iwata Kentaro; Igarashi Wataru; Honjo Midori; Nishimoto Takashi; Shinya Kyoko; Makino Akiko; Mitani Kazuo; Tatsumi Yoshiko; Ninomiya Hiroyuki; Higasa Kumi; Usuki Seiichiro; Kagawa Hiroki; Uchida Daisuke; Takimoto Kohei; Suganaga Rei; Matsuo Hiroo; Oba Yuichiro; Horigome Mami; Oka Hideaki; Ohji Goh; Abe Yasuhisa; Yoshida Hiroyuki; Kinoshita Shohiro; Hirai Midori

  Gen. Med., 2013

  
• A multicenter study to investigate the positive rate of SARS-CoV-2 in middle ear and mastoid specimens from otologic surgery patients.

  Hiroshi Yamazaki; Norio Yamamoto; Toru Sonoyama; Hayato Maruoka; Seiko Nasu; Akiko Makino; Keizo Tomonaga; Norifumi Shigemoto; Hiroki Ohge; Keizo Fujiwara; Shogo Shinohara; Sachio Takeno; Koichi Omori; Yasushi Naito

  Auris, nasus, larynx, 29 Jul. 2022

  
• Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1

  Takehiro Kanda; Madoka Sakai; Akiko Makino; Keizo Tomonaga

  Journal of General Virology, 12 Jul. 2022

  
• Stability of Borna disease virus‐based episomal vector under physical and chemical stimulation

  Mako Yanai; Madoka Sakai; Ryo Komorizono; Akiko Makino; Keizo Tomonaga

  Microbiology and Immunology, Jan. 2022, Peer-reviewed, Corresponding author

  
• BUD23-TRMT112 interacts with the L protein of Borna disease virus and mediates the chromosomal tethering of viral ribonucleoproteins.

  Bea Clarise B Garcia; Masayuki Horie; Shohei Kojima; Akiko Makino; Keizo Tomonaga

  Microbiology and immunology, 29 Jul. 2021

  
• A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability

  Kan Fujino; Masayuki Horie; Shohei Kojima; Sae Shimizu; Aya Nabekura; Hiroko Kobayashi; Akiko Makino; Tomoyuki Honda; Keizo Tomonaga

  Journal of Virology, 24 Jun. 2021

  
• Radioligand Assay-Based Detection of Antibodies against SARS-CoV-2 in Hospital Workers Treating Patients with Severe COVID-19 in Japan

  Hidenori Matsunaga; Akiko Makino; Yasuhiro Kato; Teruaki Murakami; Yuta Yamaguchi; Atsushi Kumanogoh; Yuichiro Oba; Satoshi Fujimi; Tomoyuki Honda; Keizo Tomonaga

  Viruses, 23 Feb. 2021

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• Optimal Expression of the Envelope Glycoprotein of Orthobornaviruses Determines the Production of Mature Virus Particles

  Madoka Sakai; Yoko Fujita; Ryo Komorizono; Takehiro Kanda; Yumiko Komatsu; Takeshi Noda; Keizo Tomonaga; Akiko Makino

  Journal of Virology, 10 Feb. 2021, Last author, Corresponding author

  
• Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus

  Ryo Komorizono; Yukiko Sassa; Masayuki Horie; Akiko Makino; Keizo Tomonaga

  Viruses, 11 Nov. 2020, Corresponding author

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• ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.

  Mako Yanai; Shohei Kojima; Madoka Sakai; Ryo Komorizono; Keizo Tomonaga; Akiko Makino

  Journal of virology, 28 Feb. 2020, Peer-reviewed

  
• Development of a reverse transcription-loop-mediated isothermal amplification assay for the detection of parrot bornavirus 4.

  Komorizono R; Tomonaga K; Makino A

  J Virol Methods, 2020, Peer-reviewed

  
• RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs.

  Yumiko Komatsu; Dan Takeuchi; Tomoya Tokunaga; Hidetoshi Sakurai; Akiko Makino; Tomoyuki Honda; Yasuhiro Ikeda; Keizo Tomonaga

  Molecular therapy. Methods & clinical development, 13 Sep. 2019, Peer-reviewed

  
• Intracellular dynamics of actin affects Borna disease virus replication in the nucleus.

  Hirai Y; Domae E; Yoshikawa Y; Okamura H; Makino A; Tomonaga K

  Virus research, Apr. 2019, Peer-reviewed

  
• Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector

  Sakai, M; Ueda, S; Daito, T; Asada-Utsugi, M; Komatsu, Y; Kinoshita, A; Maki, T; Kuzuya, A; Takahashi, R; Makino, A; Tomonaga, K

  Microbiol Immunol, May 2018, Peer-reviewed

  
• Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes

  Kan Fujino; Yusuke Yamamoto; Takuji Daito; Akiko Makino; Tomoyuki Honda; Keizo Tomonaga

  MICROBIOLOGY AND IMMUNOLOGY, Sep. 2017, Peer-reviewed

  
• Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein

  Mako Yanai; Madoka Sakai; Akiko Makino; Keizo Tomonaga

  VIROLOGY JOURNAL, Jul. 2017, Peer-reviewed

  
• Sequence determination of a new parrot bornavirus-5 strain in Japan: implications of clade-specific sequence diversity in the regions interacting with host factors

  Ryo Komorizono; Akiko Makino; Masayuki Horie; Tomoyuki Honda; Keizo Tomonaga

  MICROBIOLOGY AND IMMUNOLOGY, Jun. 2016, Peer-reviewed

  
• Long-term expression of miRNA for RNA interference using a novel vector system based on a negative-strand RNA virus

  Tomoyuki Honda; Yusuke Yamamoto; Takuji Daito; Yusuke Matsumoto; Akiko Makino; Keizo Tomonaga

  SCIENTIFIC REPORTS, May 2016, Peer-reviewed

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• A novel intranuclear RNA vector system for long-term stem cell modification

  Y. Ikeda; A. Makino; W. E. Matchett; S. J. Holditch; B. Lu; A. B. Dietz; K. Tomonaga

  GENE THERAPY, Mar. 2016, Peer-reviewed

  
• ボルナウイルスとバイオセーフティ

  牧野晶子; 朝長 啓造

  日本バイオセーフティ学会ニュースレター, 2016, Peer-reviewed, Invited

  
• X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories

  Yuya Hirai; Tomoyuki Honda; Akiko Makino; Yuzo Watanabe; Keizo Tomonaga

  JOURNAL OF GENERAL VIROLOGY, Oct. 2015, Peer-reviewed

  
• piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals

  Nicholas F. Parrish; Kan Fujino; Yusuke Shiromoto; Yuka W. Iwasaki; Hongseok Ha; Jinchuan Xing; Akiko Makino; Satomi Kuramochi-Miyagawa; Toru Nakano; Haruhiko Siomi; Tomoyuki Honda; Keizo Tomonaga

  RNA, Oct. 2015, Peer-reviewed

  
• Intranuclear persistent infection of Borna disease virus

  Makino A; Tomonaga K

  ANTIBIOTICS & CHEMOTHERAPY, Sep. 2015, Invited

  
• Borna disease virus possesses an NF-kappa B inhibitory sequence in the nucleoprotein gene

  Akiko Makino; Kan Fujino; Nicholas F. Parrish; Tomoyuki Honda; Keizo Tomonaga

  SCIENTIFIC REPORTS, Mar. 2015, Peer-reviewed

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• Protease-Dependent Hemagglutinin Cleavage Contributes to Alteration in Chicken Hemagglutination by the H3N2 Influenza A Virus

  Masaoki Yamaoka; Akiko Makino; Kenji Sasahara; Aldise Mareta Nastri; Luh Ade Wilan Krisna; Edith Frederika Purhito; Emmanuel Djoko Poetranto; Laksmi Wulandari; Resti Yudhawati; Landia Setiawati; Retno Asih Setyoningrum; Kyoko Shinya

  JAPANESE JOURNAL OF INFECTIOUS DISEASES, Nov. 2013, Peer-reviewed

  
• Integrated Clinical, Pathologic, Virologic, and Transcriptomic Analysis of H5N1 Influenza Virus-Induced Viral Pneumonia in the Rhesus Macaque

  Kyoko Shinya; Yuwei Gao; Cristian Cilloniz; Yasuhiro Suzuki; Masahiro Fujie; Guohua Deng; Qiyun Zhu; Shufang Fan; Akiko Makino; Yukiko Muramoto; Satoshi Fukuyama; Daisuke Tamura; Takeshi Noda; Arnie J. Eisfeld; Michael G. Katze; Hualan Chen; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, Jun. 2012, Peer-reviewed

  
• Amino Acid Changes in Hemagglutinin Contribute to the Replication of Oseltamivir-Resistant H1N1 Influenza Viruses

  Teridah Ernala Ginting; Kyoko Shinya; Yukihiro Kyan; Akiko Makino; Naomi Matsumoto; Satoko Kaneda; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, Jan. 2012, Peer-reviewed

  
• Emergence of HA mutants during influenza virus pneumonia

  Maria Eugenia Vazquez Manriquez; Akiko Makino; Motoko Tanaka; Yasuhisa Abe; Hiroyuki Yoshida; Ichiro Morioka; Soichi Arakawa; Yasuhiro Takeshima; Kentaro Iwata; Jin Takasaki; Toshie Manabe; Takaaki Nakaya; Shota Nakamura; Anjarath Lorena Higuera Iglesias; Rosa Maria Rivera Rossales; Erika Pena Mirabal; Tateki Ito; Toshio Kitazawa; Teruaki Oka; Makoto Yamashita; Koichiro Kudo; Kyoko Shinya

  INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2012, Peer-reviewed

  
• The TLR4-TRIF Pathway Protects against H5N1 Influenza Virus Infection

  Kyoko Shinya; Mutsumi Ito; Akiko Makino; Motoko Tanaka; Kensuke Miyake; Amie J. Eisfeld; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, Jan. 2012, Peer-reviewed

  
• Avian-Type Receptor-Binding Ability Can Increase Influenza Virus Pathogenicity in Macaques

  Tokiko Watanabe; Kyoko Shinya; Shinji Watanabe; Masaki Imai; Masato Hatta; Chengjun Li; Ben F. Wolter; Gabriele Neumann; Anthony Hanson; Makoto Ozawa; Shinya Yamada; Hirotaka Imai; Saori Sakabe; Ryo Takano; Kiyoko Iwatsuki-Horimoto; Maki Kiso; Mutsumi Ito; Satoshi Fukuyama; Eiryo Kawakami; Takeo Gorai; Heather A. Simmons; Daniel Schenkman; Kevin Brunner; Saverio V. Capuano; Jason T. Weinfurter; Wataru Nishio; Yoshimasa Maniwa; Tatsuhiko Igarashi; Akiko Makino; Emily A. Travanty; Jieru Wang; Anette Kilander; Susanne G. Dudman; M. Suresh; Robert J. Mason; Olav Hungnes; Thomas C. Friedrich; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, Dec. 2011, Peer-reviewed

  
• Identification of Amino Acids in Marburg Virus VP40 That Are Important for Virus-Like Particle Budding

  Akiko Makino; Seiya Yamayoshi; Kyoko Shinya; Takeshi Noda; Yoshihiro Kawaoka

  JOURNAL OF INFECTIOUS DISEASES, Nov. 2011, Peer-reviewed

  
• Identification of Amino Acids in Marburg Virus VP40 That Are Important for Virus-Like Particle Budding

  Akiko Makino; Seiya Yamayoshi; Kyoko Shinya; Takeshi Noda; Yoshihiro Kawaoka

  JOURNAL OF INFECTIOUS DISEASES, Nov. 2011, Peer-reviewed

  
• An H5N1 highly pathogenic avian influenza virus isolated from a local tree sparrow in Indonesia

  Emmanuel Djoko Poetranto; Masaoki Yamaoka; Aldise Mareta Nastri; Luh Ade Wilan Krisna; Maulana Hanief Rahman; Laksmi Wulandari; Resti Yudhawati; Teridah Ernala Ginting; Akiko Makino; Kyoko Shinya; Yoshihiro Kawaoka

  MICROBIOLOGY AND IMMUNOLOGY, Sep. 2011, Peer-reviewed

  
• Virological surveillance of human influenza in Indonesia, October 2008-March 2010

  Masaoki Yamaoka; Justinus F. Palilingan; Jusuf Wibisono; Resti Yudhawati; Reviany V. Nidom; Muhamad Y. Alamudi; Teridah E. Ginting; Akiko Makino; Chairul A. Nidom; Kyoko Shinya; Yoshihiro Kawaoka

  MICROBIOLOGY AND IMMUNOLOGY, Jul. 2011, Peer-reviewed

  
• Systemic Dissemination of H5N1 Influenza A Viruses in Ferrets and Hamsters after Direct Intragastric Inoculation

  Kyoko Shinya; Akiko Makino; Hiroji Tanaka; Masato Hatta; Tokiko Watanabe; Mai Q. Le; Hirotaka Imai; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, May 2011, Peer-reviewed

  
• Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection

  Kyoko Shinya; Akiko Makino; Masato Hatta; Shinji Watanabe; Jin Hyun Kim; Yasuko Hatta; Peng Gao; Makoto Ozawa; Quynh Mai Le; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, May 2011, Peer-reviewed

  
• Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

  Kyoko Shinya; Tadashi Okamura; Setsuko Sueta; Noriyuki Kasai; Motoko Tanaka; Teridah E. Ginting; Akiko Makino; Amie J. Eisfeld; Yoshihiro Kawaoka

  VIROLOGY JOURNAL, Mar. 2011, Peer-reviewed

  
• Characteristics of influenza virus genome mutations

  Motoko Tanaka; Kyoko Tsumura; Hiroshi Ito; Toshihiro Ito; Etsuro Ono; Akiko Makino; Yoshihiro Kawaoka; Kyoko Shinya

  Kobe Journal of Medical Sciences, 2011, Peer-reviewed

  
• A case of pandemic 2009 influenza A (H1N1) in a patient with HIV infection

  Kentaro Iwata; Kyoko Shinya; Akiko Makino; Hiroyuki Yoshida; Shohiro Kinoshita; Goh Ohji; Ken Kato

  JOURNAL OF INFECTION AND CHEMOTHERAPY, Aug. 2010, Peer-reviewed

  
• A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage

  Kyoko Shinya; Akiko Makino; Masato Hatta; Shinji Watanabe; Jin Hyun Kim; Yoshihiro Kawaoka

  JOURNAL OF GENERAL VIROLOGY, Jun. 2010, Peer-reviewed

  
• Emerging and reemerging influenza virus infections

  Kyoko Shinya; A. Makino; Y. Kawaoka

  Veterinary Pathology, 2010, Peer-reviewed

  
• Ostrich Involvement in the Selection of H5N1 Influenza Virus Possessing Mammalian-Type Amino Acids in the PB2 Protein

  Kyoko Shinya; Akiko Makino; Makoto Ozawa; Jin Hyun Kim; Yuko Sakai-Tagawa; Mutsumi Ito; Quynh Mai Le; Yoshihiro Kawaoka

  JOURNAL OF VIROLOGY, Dec. 2009, Peer-reviewed

  
• In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

  Yasushi Itoh; Kyoko Shinya; Maki Kiso; Tokiko Watanabe; Yoshihiro Sakoda; Masato Hatta; Yukiko Muramoto; Daisuke Tamura; Yuko Sakai-Tagawa; Takeshi Noda; Saori Sakabe; Masaki Imai; Yasuko Hatta; Shinji Watanabe; Chengjun Li; Shinya Yamada; Ken Fujii; Shin Murakami; Hirotaka Imai; Satoshi Kakugawa; Mutsumi Ito; Ryo Takano; Kiyoko Iwatsuki-Horimoto; Masayuki Shimojima; Taisuke Horimoto; Hideo Goto; Kei Takahashi; Akiko Makino; Hirohito Ishigaki; Misako Nakayama; Masatoshi Okamatsu; Kazuo Takahashi; David Warshauer; Peter A. Shult; Reiko Saito; Hiroshi Suzuki; Yousuke Furuta; Makoto Yamashita; Keiko Mitamura; Kunio Nakano; Morio Nakamura; Rebecca Brockman-Schneider; Hiroshi Mitamura; Masahiko Yamazaki; Norio Sugaya; M. Suresh; Makoto Ozawa; Gabriele Neumann; James Gern; Hiroshi Kida; Kazumasa Ogasawara; Yoshihiro Kawaoka

  NATURE, Aug. 2009, Peer-reviewed

  
• Generation of Vero Cells Expressing Ebola Virus Glycoprotein

  Akiko Makino; Yoshihiro Kawaoka

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Apr. 2009, Peer-reviewed

  
• Binding Properties of GP1 Protein of Borna Disease Virus

  Akiko Makino; Taisuke Horimoto; Yoshihiro Kawaoka

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Feb. 2009, Peer-reviewed

  
• Junctional adhesion molecule 1 is a functional receptor for feline calicivirus

  A Makino; M Shimojima; T Miyazawa; K Kato; Y Tohya; H Akashi

  JOURNAL OF VIROLOGY, May 2006, Peer-reviewed

  
• [Avian influenza virus].

  Makino A; Kawaoka Y

  Nihon rinsho. Japanese journal of clinical medicine, Dec. 2005, Peer-reviewed

  

Misc.

• Genome-wide CRISPR screening for host factors involved in bornavirus cell entry

  松郷宙倫; 松郷宙倫; 遊佐宏介; 牧野晶子; 牧野晶子; 朝長啓造; 朝長啓造; 朝長啓造

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2024

  
• トリボルナウイルス自然感染鳥における皮膚病変とウイルス局在の解析

  芳野素一; 相原尚之; 志賀崇徳; 曽我玲子; 牧野晶子; 朝長啓造; 上家潤一

  日本獣医学会学術集会講演要旨集, 2022

  
• Genome-wide CRISPR screening for host factors involved in persistent bornavirus infection

  MATSUGO Hiromichi; YUSA Kosuke; MAKINO Akiko; TOMONAGA Keizo

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• ゲノムワイドCRISPRスクリーニングによるボルナウイルスの転写・複製・持続感染に関わる宿主因子の探索

  松郷宙倫; 遊佐宏介; 牧野晶子; 朝長啓造; 松郷宙倫; 牧野晶子; 朝長啓造; 朝長啓造

  日本獣医学会学術集会講演要旨集, 2023

  
• オウム目におけるトリボルナウイルス感染症の病理学的検索

  藤原千夏; 相原尚之; 小森園亮; 牧野晶子; 朝長啓造; 曽我玲子; 上家潤一

  日本獣医学会学術集会講演要旨集, 2019

  
• 鳥ボルナウイルスParrot bornavirus4のリバースジェネティクス法の確立

  小森園亮; 小森園亮; 藤野寛; 堀江真行; 堀江真行; KESSLER Susanne; RUNGE Solveig; 神田雄大; 神田雄大; 牧野晶子; 牧野晶子; RUBBENSTROTH Dennis; 朝長啓造; 朝長啓造; 朝長啓造

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2019

  
• 日本国内の愛玩鳥繁殖場における鳥ボルナウイルス感染症の流行

  小森園亮; 小森園亮; 竹前喜洋; 上家潤一; 曽我玲子; 牧野晶子; 牧野晶子; 朝長啓造; 朝長啓造

  日本獣医学会学術集会講演要旨集, 2018

  
• Development of Borna Disease Virus Vector for Differentiation of Human iPSCs into Skeletal Muscle Cells

  Yumiko Komatsu; Dan Takeuchi; Hidetoshi Sakurai; Yasuhiro Ikeda; Yusuke Yamamoto; Tomoyuki Honda; Akiko Makino; Keizo Tomonaga

  MOLECULAR THERAPY, May 2017

  
• Improvement of the production of Borna disease virus vector

  A. Makino; R. Komorizono; M. Sakai; K. Tomonaga

  HUMAN GENE THERAPY, Nov. 2016

  
• A novel intranuclear RNA vector system for long-term stem cell modification

  Y. Ikeda; A. Makino; W. E. Matchett; S. J. Holditch; B. Lu; A. B. Dietz; K. Tomonaga

  GENE THERAPY, Mar. 2016, Peer-reviewed

  
• A novel RNA virus-based episomal vector system for long-term stem cell modification

  A. Makino; R. Komorizono; S. J. Holditch; B. Lu; T. Honda; Y. Ikeda; K. Tomonaga

  HUMAN GENE THERAPY, Oct. 2015

  
• A novel RNA virus vector system for small RNA deliery based on Borna disease virus

  T. Honda; Y. Yamamoto; Y. Matsumoto; A. Makino; K. Tomonaga

  HUMAN GENE THERAPY, Oct. 2015

  
• The regulation of Borna disease virus production

  Akiko Makino; Tomoyuki Honda; Keizo Tomonaga

  The 14th Awaji International Forum on Infection and Immunity, Sep. 2015, Peer-reviewed

  
• IGF2 is involved in the regulation of Borna disease virus production.

  Akiko Makino; Tomoyuki Honda; Keizo Tomonaga

  Negative Strand RNA virus meeting 2015, Jun. 2015, Peer-reviewed

  
• IGF2によるボルナ病ウイルス粒子産生制御機構の解析

  牧野晶子; 藤野寛; 平井悠哉; 本田知之; 朝長啓造

  第8回日本ボルナウイルス研究会, Mar. 2015, Peer-reviewed

  
• IGF2によるボルナ病ウイルス粒子産生 制御機構の解析

  牧野晶子; 藤野寛; 平井悠哉; 惣福梢; 本田知之; 朝長啓造

  第4回Negative Strand Virus-Japan, Jan. 2015, Peer-reviewed

  
• ボルナ病ウイルス粒子産生に対する宿主因子IGF2の関与

  牧野晶子; 藤野寛; 平井悠哉; 惣福梢; 本田知之; 朝長啓造

  第62回日本ウイルス学会, Nov. 2014, Peer-reviewed

  
• ハダカデバネズミのゲノムに内在化したレトロウイルス様配列の解析

  牧野晶子; 宮沢孝幸; 鈴木善幸; 三浦恭子; 朝長啓造

  第157回日本獣医学会学術集会, Sep. 2014, Peer-reviewed

  
• Expression of IGF2 affects Borna disease virus production in infected cells

  Akiko Makino; Kan Fujino; Takuji Daito; Tomoyuki Honda; Keizo Tomonaga

  International Union of Microbiological Societies Congresses, Jul. 2014, Peer-reviewed

  
• ボルナウイルスの粒子産生制御機構の解析

  牧野晶子; 藤野寛; 大東卓史; 本田知之; 朝長啓造

  第3回Negative Strand Virus-Japan, Jan. 2014, Peer-reviewed

  
• ボルナ病ウイルスNタンパク質のアンキリン様配列を介したNF-κ B活性化阻害

  牧野晶子; 藤野寛; 惣福梢; 中村祥子; 本田知之; 朝長啓造

  第61回日本ウイルス学会, Nov. 2013, Peer-reviewed

  
• Inhibition of NF-κB activation by peptide derived from nucleoprotein of Borna disease virus.

  Akiko Makino; Kan Fujino; Kozue Sofuku; Shoko Nakamura; Tomoyuki Honda; Keizo Tomonaga

  15th International Negative Strand Virus Meeting, Jun. 2013, Peer-reviewed

  
• ウイルスタンパク質内のTLRシグナル伝達阻害ペプチドの探索と評価

  牧野晶子; 藤野寛; 惣福梢; 中村祥子; 伊藤睦美; 本田知之; 新矢恭子; 河岡義裕; 朝長啓造

  第六回ボルナウイルス研究会, Mar. 2013, Peer-reviewed

  
• 内在性ボルナ病ウイルス様エレメントによるボルナ病ウイルスの新しい制御機構

  本田知之; 小嶋将平; 牧野晶子; 藤野寛; 惣福梢; 朝長啓造

  日本ウイルス学会学術集会プログラム・抄録集, 2013

  
• A型インフルエンザウイルス感染におけるムチン型糖転移酵素GALNT3の機能解析

  中村祥子; 堀江真行; 安木真世; 大道寺智; 久野敦; 奥崎大介; 牧野晶子; 本田知之; 成松久; 中屋隆明; 朝長啓造

  日本ウイルス学会学術集会プログラム・抄録集, 2013

  
• A型インフルエンザウイルス感染におけるムチン型糖転移酵素GALNT3の機能解析

  中村祥子; 堀江真行; 安木真世; 大道寺智; 久野敦; 奥崎大介; 牧野晶子; 本田知之; 成松久; 中屋隆明; 朝長啓造

  日本分子生物学会年会プログラム・要旨集(Web), 2013

  
• ハダカデバネズミを用いた内在性ウイルス様配列の検出とウイルス感受性の解析

  牧野晶子; 三浦恭子; 岡野栄之; 朝長啓造

  第60回日本ウイルス学会, Nov. 2012, Peer-reviewed

  
• A型インフルエンザウイルス感染によるムチン型糖転移酵素GALNT3の発現制御機序と意義の解析

  中村祥子; 堀江真行; 安木真世; 奥崎大介; 牧野晶子; 本田知之; 朝長啓造

  日本ウイルス学会学術集会プログラム・抄録集, 2012

  
• A型インフルエンザウイルス感染によるムチン型糖転移酵素GALNT3の発現制御機序と意義の解析

  中村祥子; 中村祥子; 堀江真行; 安木真世; 奥崎大介; 牧野晶子; 本田知之; 朝長啓造

  日本生化学会大会(Web), 2012

  
• ボルナウイルス 感染細胞における核内ウイルスRNP の制御機構の解明

  本田知之; 松本祐介; 牧野晶子; 藤野 寛; 惣福 梢; 中村祥子; 朝長啓造

  第35回日本分子生物学会年会. 福岡 2012 年12月11-14日, 2012, Peer-reviewed

  
• ボルナ病ウイル ス核内構造物の存在意義の解明

  本田知之; 松本祐介; 牧野晶子; 藤野 寛; 惣福 梢; 中村祥子; 朝長啓造

  第60回日本ウイルス学会学術集会. 大阪 2012 年 11月13-15日, 2012, Peer-reviewed

  
• Characterization of Borna disease virus-induced RNA speckles in the nucleus.

  Honda T; Matsumoto Y; Makino A; Fujino K; Sofiiku K; Nakamura S; Tomonaga K

  The 11th Awaji International Forum on Infection and Immunity. 11-14 September 2012, 2012, Peer-reviewed

  

Presentations

• Development of borna disease virus vector system.

  Akiko Makino

  Special seminar at Mayo clinic, 24 Jul. 2014, Invited

  

Awards

• 17 Sep. 2015

  European Society of Gene and Cell Therapy, Travel Grant for ESGCT Congress 2015

External funds: Kakenhi

• エマージングリスクであるボルナ病ウイルスの制御法確立

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49060:Virology-related

  Kyoto University

  牧野 晶子

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  エマージングリスク;人獣共通感染症;抗ウイルス化合物;RNA;ウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07053/
• ボルナウイルスの核内持続感染が解き明かすウイルス進化戦略の多様性

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  牧野 晶子

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  ウイルス進化;多様性;核内複製

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04834/
• Risk assessment and pathogenicity of highly pathogenic emerging bornavirus

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42020:Veterinary medical science-related

  Kyoto University

  Akiko Makino

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  人獣共通感染症;高病原性;RNAウイルス;ウイルス;リバースジェネティクス;病原性;ボルナウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K05991/
• Generation of episomal RNA viral vector for stem cell gene therapy

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Akiko Makino

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ウイルスベクター;幹細胞;RNAウイルスベクター;遺伝子治療;幹細胞遺伝子治療;ボルナウイルスベクター;X-SCID;エピソーマル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19069/

External funds: others

• 先端的順逆遺伝学手法を用いたSARS-CoV-2の伝播機構解明

  新興・再興感染症研究基盤創生事業 多分野融合研究領域

  From 15 Jun. 2020, To 31 Mar. 2022

  牧野　晶子

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course in Immunology and Human Disorders

  1031, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar

  2005, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Immunology and Human Disorders

  1031, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar

  2005, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar

  2005, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From Apr. 2015, To Mar. 2016

  The Front Line of Life Science Research II

  Spring, 全学共通科目

Administration

Faculty management (title, position)

• From 01 Apr. 2024

  広報委員会　委員
• From 01 Apr. 2024

  医生物学研究所　研究支援室　広報ユニット
• From 20 Jul. 2023

  学術委員会　委員
• From 01 Apr. 2023

  男女共同参画推進委員会　委員
• From 01 Apr. 2022

  教育委員会
• From 01 Oct. 2016

  化学物質管理委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2017

  化学物質委員会　委員