Basic Information

Concurrent Affiliation

• Graduate School of Medicine, 医学研究科 医学専攻

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  201401006798756725

researchmap URL

• https://researchmap.jp/7000008774

Research

Research Topics, Overview of the research

• Research Topics

  Clinical and basic reserch of Interstitial lung diseases

Papers

• Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients?

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Toru Oga; Takeshi Kubo; Yutaka Ito; Kensaku Aihara; Kohei Ikezoe; Akihiko Sokai; Yoshinari Nakatsuka; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima; Takateru Izumi

  Respiratory medicine, Mar. 2019, Peer-reviewed

  
• Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease.

  Nakatsuka Y; Handa T; Nakashima R; Tanizawa K; Kubo T; Murase Y; Sokai A; Ikezoe K; Hosono Y; Watanabe K; Tokuda S; Uno K; Yoshizawa A; Tsuruyama T; Uozumi R; Nagai S; Hatta K; Taguchi Y; Mishima M; Chin K; Mimori T; Hirai T

  Rheumatology (Oxford)., 2019, Peer-reviewed

  
• Nutrition-related factors associated with waiting list mortality in patients with interstitial lung disease: A retrospective cohort study.

  Oshima A; Nishimura A; Chen-Yoshikawa TF; Harashima SI; Komatsu T; Handa T; Aoyama A; Takahashi K; Ikeda M; Oshima Y; Ikezoe K; Sato S; Isomi M; Shide K; Date H; Inagaki N

  Clin Transplant., 2019, Peer-reviewed

  
• The long-term outcome of interstitial lung disease with antiaminoacyl-tRNA synthetase antibodies

  Kiminobu Tanizawa; Tomohiro Handa; Ran Nakashima; Takeshi Kubo; Yuji Hosono; Kizuku Watanabe; Kensaku Aihara; Kohei Ikezoe; Akihiko Sokai; Yoshinari Nakatsuka; Yoshio Taguchi; Kazuhiro Hatta; Satoshi Noma; Yoichiro Kobashi; Akihiko Yoshizawa; Toru Oga; Toyohiro Hirai; Kazuo Chin; Sonoko Nagai; Takateru Izumi; Tsuneyo Mimori; Michiaki Mishima

  RESPIRATORY MEDICINE, Jun. 2017, Peer-reviewed

  
• Outcomes of various transplant procedures (single, sparing, inverted) in living-donor lobar lung transplantation

  Hiroshi Date; Akihiro Aoyama; Kyoko Hijiya; Hideki Motoyama; Tomohiro Handa; Hideyuki Kinoshita; Shiro Baba; Toshiyuki Mizota; Kenji Minakata; Toyofumi F. Chen-Yoshikawa

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Feb. 2017, Peer-reviewed

  
• Comprehensive evaluation of airway involvement in pulmonary sarcoidosis

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Akio Niimi; Tsuyoshi Oguma; Takeshi Kubo; Yutaka Ito; Kensaku Aihara; Kohei Ikezoe; Hisako Matsumoto; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  ERJ Open Research, 01 Jan. 2017, Peer-reviewed

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• F-18-FDG Uptake in Less Affected Lung Field Provides Prognostic Stratification in Patients with Interstitial Lung Disease

  Tomomi Nobashi; Takeshi Kubo; Yuji Nakamoto; Tomohiro Handa; Sho Koyasu; Takayoshi Ishimori; Michiaki Mishima; Kaori Togashi

  JOURNAL OF NUCLEAR MEDICINE, Dec. 2016, Peer-reviewed

  
• The utility of PET/CT with Ga-68-DOTATOC in sarcoidosis: comparison with Ga-67-scintigraphy

  Tomomi Nobashi; Yuji Nakamoto; Takeshi Kubo; Takayoshi Ishimori; Tomohiro Handa; Kiminobu Tanizawa; Kohei Sano; Michiaki Mishima; Kaori Togashi

  ANNALS OF NUCLEAR MEDICINE, Oct. 2016, Peer-reviewed

  
• Microalbuminuria in Patients with Obstructive Sleep Apnea-Chronic Obstructive Pulmonary Disease Overlap Syndrome.

  Matsumoto T; Murase K; Tachikawa R; Minami T; Hamada S; Tanizawa K; Inouchi M; Handa T; Oga T; Yanagita M; Mishima M; Chin K

  Annals of the American Thoracic Society, Jun. 2016, Peer-reviewed

  
• Role of mitochondrial hydrogen peroxide induced by intermittent hypoxia in airway epithelial wound repair in vitro

  Satoshi Hamada; Atsuyasu Sato; Mariko Hara-Chikuma; Hiroki Satooka; Koichi Hasegawa; Kazuya Tanimura; Kiminobu Tanizawa; Morito Inouchi; Tomohiro Handa; Toru Oga; Shigeo Muro; Michiaki Mishima; Kazuo Chin

  EXPERIMENTAL CELL RESEARCH, May 2016, Peer-reviewed

  
• Aquaporin-3 potentiates allergic airway inflammation in ovalbumininduced murine asthma

  Kohei Ikezoe; Toru Oga; Tetsuya Honda; Mariko Hara-Chikuma; Xiaojun Ma; Tatsuaki Tsuruyama; Kazuko Uno; Jun-ichi Fuchikami; Kiminobu Tanizawa; Tomohiro Handa; Yoshio Taguchi; Alan S. Verkman; Shuh Narumiya; Michiaki Mishima; Kazuo Chin

  SCIENTIFIC REPORTS, May 2016, Peer-reviewed

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• Serial perfusion in native lungs in patients with idiopathic pulmonary fibrosis and other interstitial lung diseases after single lung transplantation

  Akihiko Sokai; Tomohiro Handa; Fengshi Chen; Kiminobu Tanizawa; Akihiro Aoyama; Takeshi Kubo; Kohei Ikezoe; Yoshinari Nakatsuka; Tsuyoshi Oguma; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Hiroshi Date; Michiaki Mishima

  CLINICAL TRANSPLANTATION, Apr. 2016, Peer-reviewed

  
• Two cases of autoimmune and secondary pulmonary alveolar proteinosis during immunosuppressive therapy in dermatomyositis with interstitial lung disease.

  Imura Y; Yukawa N; Handa T; Nakashima R; Murakami K; Yoshifuji H; Ohmura K; Ishii H; Nakata K; Mimori T

  Modern rheumatology, Mar. 2016, Peer-reviewed

  
• PLATELET AGGREGABILITY IN PATIENTS WITH INTERSTITIAL PNEUMONIAS

  Tomohiro Handa; Kizuku Watanabe; Kiminobu Tanizawa; Toru Oga; Kensaku Aihara; Kohei Ikezoe; Akihiko Sokai; Yoshinari Nakatsuka; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Hisanori Horiuchi; Michiaki Mishima

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 2016, Peer-reviewed

  
• Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis

  Akihiko Sokai; Tomohiro Handa; Kiminobu Tanizawa; Toru Oga; Kazuko Uno; Tatsuaki Tsuruyama; Takeshi Kubo; Kohei Ikezoe; Yoshinari Nakatsuka; Kazuya Tanimura; Shigeo Muro; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Michiaki Mishima

  RESPIRATORY RESEARCH, Sep. 2015, Peer-reviewed

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• Bone mineral density in patients with idiopathic pulmonary fibrosis

  Kohei Ikezoe; Tomohiro Handa; Kiminobu Tanizawa; Takeshi Kubo; Tsuyoshi Oguma; Satoshi Hamada; Kizuku Watanabe; Kensaku Aihara; Akihiko Sokai; Yoshinari Nakatsuka; Shigeo Muro; Sonoko Nagai; Kazuko Uno; Kazuo Chin; Motonari Fukui; Toyohiro Hirai; Michiaki Mishima

  RESPIRATORY MEDICINE, Sep. 2015, Peer-reviewed

  
• Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Toyohiro Hirai; Takeshi Kubo; Tsuyoshi Oguma; Isao Ito; Yutaka Ito; Kizuku Watanabe; Kensaku Aihara; Kohei Ikezoe; Toru Oga; Kazuo Chin; Takateru Izumi; Michiaki Mishima

  BMC PULMONARY MEDICINE, Jul. 2015, Peer-reviewed

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• Total lesion glycolysis as an IgG4-related disease activity marker

  Yoshinari Nakatsuka; Tomohiro Handa; Yuji Nakamoto; Tomomi Nobashi; Hajime Yoshihuji; Kiminobu Tanizawa; Kohei Ikezoe; Akihiko Sokai; Takeshi Kubo; Toyohiro Hirai; Kazuo Chin; Kaori Togashi; Tsuneyo Mimori; Michiaki Mishima

  MODERN RHEUMATOLOGY, Jul. 2015, Peer-reviewed

  
• Living-donor lobar lung transplantation provides similar survival to cadaveric lung transplantation even for very ill patients

  Hiroshi Date; Masaaki Sato; Akihiro Aoyama; Tetsu Yamada; Toshiyuki Mizota; Hideyuki Kinoshita; Tomohiro Handa; Kiminobu Tanizawa; Kazuo Chin; Kenji Minakata; Fengshi Chen

  EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Jun. 2015, Peer-reviewed

  
• A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis

  K. Ikezoe; T. Handa; K. Tanizawa; T. Kubo; I. Ito; A. Sokai; Y. Nakatsuka; S. Nagai; T. Izumi; M. Mishima

  TISSUE ANTIGENS, Mar. 2015, Peer-reviewed

  
• Pleuroparenchymal fibroelastosis and non-specific interstitial pneumonia: frequent pulmonary sequelae of haematopoietic stem cell transplantation

  Yasuhide Takeuchi; Aya Miyagawa-Hayashino; Fengshi Chen; Takeshi Kubo; Tomohiro Handa; Hiroshi Date; Hironori Haga

  HISTOPATHOLOGY, Mar. 2015, Peer-reviewed

  
• Impact of Obstructive Sleep Apnea on Abdominal Aortic Diameters

  Ryo Tachikawa; Satoshi Hamada; Masanori Azuma; Yoshiro Toyama; Kimihiko Murase; Kiminobu Tanizawa; Morito Inouchi; Tomohiro Handa; Toru Oga; Michiaki Mishima; Kazuo Chin

  AMERICAN JOURNAL OF CARDIOLOGY, Aug. 2014, Peer-reviewed

  
• Neutrophil gelatinase-associated lipocalin in idiopathic pulmonary fibrosis

  Kohei Ikezoe; Tomohiro Handa; Kiyoshi Mori; Kizuku Watanabe; Kiminobu Tanizawa; Kensaku Aihara; Tatsuaki Tsuruyama; Aya Miyagawa-Hayashino; Akihiko Sokai; Takeshi Kubo; Shigeo Muro; Sonoko Nagai; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  EUROPEAN RESPIRATORY JOURNAL, Jun. 2014, Peer-reviewed

  
• The Multicenter Study of a New Assay for Simultaneous Detection of Multiple Anti-Aminoacyl-tRNA Synthetases in Myositis and Interstitial Pneumonia

  Ran Nakashima; Yoshitaka Imura; Yuji Hosono; Minae Seto; Akihiro Murakami; Kizuku Watanabe; Tomohiro Handa; Michiaki Mishima; Michito Hirakata; Tsutomu Takeuchi; Keishi Fujio; Kazuhiko Yamamoto; Hitoshi Kohsaka; Yoshinari Takasaki; Noriyuki Enomoto; Takafumi Suda; Kingo Chida; Shu Hisata; Toshihiro Nukiwa; Tsuneyo Mimori

  PLOS ONE, Jan. 2014, Peer-reviewed

  
• Videothoracoscopy-assisted surgical lung biopsy for interstitial lung diseases

  M. Sonobe; T. Handa; K. Tanizawa; M. Sato; T. Sato; F. Chen; M. Omasa; T. Bando; H. Date; M. Mishima

  General Thoracic and Cardiovascular Surgery, 2014, Peer-reviewed

  
• Treatment with Methotrexate and Low-dose Corticosteroids in Sarcoidosis Patients with Cardiac Lesions

  Sonoko Nagai; Takafumi Yokomatsu; Kiminobu Tanizawa; Kohei Ikezoe; Tomohiro Handa; Yutaka Ito; Shunpei Ogino; Takateru Izumi

  INTERNAL MEDICINE, 2014, Peer-reviewed

  
• Clinical features of three cases with pulmonary alveolar proteinosis secondary to myelodysplastic syndrome developed during the course of Behçet's disease

  Tomohiro Handa; Takeshi Nakatsue; Motoo Baba; Toshinori Takada; Koh Nakata; Haruyuki Ishii

  Respiratory Investigation, Jan. 2014, Peer-reviewed

  
• BMPR2 gene mutation in pulmonary arteriovenous malformation and pulmonary hypertension: A case report

  Tomohiro Handa; Yoshiaki Okano; Norifumi Nakanishi; Takayuki Morisaki; Hiroko Morisaki; Michiaki Mishima

  Respiratory Investigation, 2014, Peer-reviewed

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• Predictive factors for reintubation following noninvasive ventilation in patients with respiratory complications after living donor liver transplantation

  Yuichi Chihara; Hiroto Egawa; Toru Oga; Tomomasa Tsuboi; Tomohiro Handa; Shintaro Yagi; Taku Iida; Atsushi Yoshizawa; Kazuhiko Yamamoto; Michiaki Mishima; Koichi Tanaka; Shinji Uemoto; Kazuo Chin

  PLoS ONE, 05 Dec. 2013, Peer-reviewed

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• Interferon regulatory factor 5 polymorphisms in sarcoidosis

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Hiroe Sato; Ryo Yamada; Isao Ito; Takeshi Kubo; Yutaka Ito; Kizuku Watanabe; Kensaku Aihara; Kohei Ikezoe; Michiaki Mishima; Takateru Izumi

  MODERN RHEUMATOLOGY, Nov. 2013, Peer-reviewed

  
• Clinical Relevance of Plasma Prostaglandin F-2 alpha Metabolite Concentrations in Patients with Idiopathic Pulmonary Fibrosis

  Kensaku Aihara; Tomohiro Handa; Toru Oga; Kizuku Watanabe; Kiminobu Tanizawa; Kohei Ikezoe; Yoshio Taguchi; Hiroe Sato; Kazuo Chin; Sonoko Nagai; Shuh Narumiya; Athol U. Wells; Michiaki Mishima

  PLOS ONE, Jun. 2013, Peer-reviewed

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• Measurement of dyspnea in patients with obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Chikara Yoshimura; Takefumi Hitomi; Yuichi Chihara; Yuka Harada; Kimihiko Murase; Yoshiro Toyama; Kiminobu Tanizawa; Tomohiro Handa; Tomomasa Tsuboi; Michiaki Mishima; Kazuo Chin

  SLEEP AND BREATHING, May 2013, Peer-reviewed

  
• Analysis of systemic and airway inflammation in obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Yuichi Chihara; Yuka Harada; Kiminobu Tanizawa; Tomohiro Handa; Takefumi Hitomi; Kazuko Uno; Michiaki Mishima; Kazuo Chin

  SLEEP AND BREATHING, May 2013, Peer-reviewed

  
• The prognostic value of HRCT in myositis-associated interstitial lung disease

  Kiminobu Tanizawa; Tomohiro Handa; Ran Nakashima; Takeshi Kubo; Yuji Hosono; Kensaku Aihara; Kohei Ikezoe; Kizuku Watanabe; Yoshio Taguchi; Kazuhiro Hatta; Toru Oga; Kazuo Chin; Sonoko Nagai; Tsuneyo Mimori; Michiaki Mishima

  Respiratory Medicine, May 2013, Peer-reviewed

  
• Analysis of systemic and airway inflammation in obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Yuichi Chihara; Yuka Harada; Kiminobu Tanizawa; Tomohiro Handa; Takefumi Hitomi; Kazuko Uno; Michiaki Mishima; Kazuo Chin

  SLEEP AND BREATHING, May 2013, Peer-reviewed

  
• Measurement of dyspnea in patients with obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Chikara Yoshimura; Takefumi Hitomi; Yuichi Chihara; Yuka Harada; Kimihiko Murase; Yoshiro Toyama; Kiminobu Tanizawa; Tomohiro Handa; Tomomasa Tsuboi; Michiaki Mishima; Kazuo Chin

  SLEEP AND BREATHING, May 2013, Peer-reviewed

  
• Flexible Positive Airway Pressure Improves Treatment Adherence Compared with Auto-adjusting PAP

  Yuichi Chihara; Tomomasa Tsuboi; Takefumi Hitomi; Masanori Azuma; Kimihiko Murase; Yoshiro Toyama; Yuka Harada; Kensaku Aihara; Kiminobu Tanizawa; Tomohiro Handa; Chikara Yoshimura; Toru Oga; Kazuhiko Yamamoto; Michiaki Mishima; Kazuo Chin

  SLEEP, Feb. 2013, Peer-reviewed

  
• Impaired endothelium-dependent vasodilator response in patients with pulmonary fibrosis

  Kensaku Aihara; Tomohiro Handa; Sonoko Nagai; Kiminobu Tanizawa; Kohei Ikezoe; Kizuku Watanabe; Yuichi Chihara; Yuka Harada; Chikara Yoshimura; Toru Oga; Neiko Ozasa; Kazuko Uno; Kazuo Chin; Michiaki Mishima

  RESPIRATORY MEDICINE, Feb. 2013, Peer-reviewed

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• Association between Plasma Neutrophil Gelatinase Associated Lipocalin Level and Obstructive Sleep Apnea or Nocturnal Intermittent Hypoxia

  Kimihiko Murase; Kiyoshi Mori; Chikara Yoshimura; Kensaku Aihara; Yuichi Chihara; Masanori Azuma; Yuka Harada; Yoshiro Toyama; Kiminobu Tanizawa; Tomohiro Handa; Takefumi Hitomi; Toru Oga; Michiaki Mishima; Kazuo Chin

  PLoS ONE, 14 Jan. 2013, Peer-reviewed

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• Interstitial pneumonias associated with anti-ARS antibody and anti-CADM antibody

  T. Handa

  Japanese Journal of Chest Diseases, 2013, Peer-reviewed

  
• Pulmonary hypertension in sarcoidosis

  T. Handa; S. Nagaj

  Japanese Journal of Chest Diseases, 2013, Peer-reviewed

  
• Prognostic Significance of Preexisting Interstitial Lung Disease in Japanese Patients With Small-Cell Lung Cancer

  Yosuke Togashi; Katsuhiro Masago; Tomohiro Handa; Kiminobu Tanizawa; Chiyuki Okuda; Yuichi Sakamori; Hiroki Nagai; Young Hak Kim; Michiaki Mishima

  CLINICAL LUNG CANCER, Jul. 2012, Peer-reviewed

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• Analysis of anatomical and functional determinants of obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Yuka Harada; Yuichi Chihara; Tomohiro Handa; Kiminobu Tanizawa; Kizuku Watanabe; Takefumi Hitomi; Tomomasa Tsuboi; Michiaki Mishima; Kazuo Chin

  SLEEP AND BREATHING, Jun. 2012, Peer-reviewed

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• Analysis of anatomical and functional determinants of obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Yuka Harada; Yuichi Chihara; Tomohiro Handa; Kiminobu Tanizawa; Kizuku Watanabe; Takefumi Hitomi; Tomomasa Tsuboi; Michiaki Mishima; Kazuo Chin

  SLEEP AND BREATHING, Jun. 2012, Peer-reviewed

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• Impact of nasal continuous positive airway pressure for congenital adrenal hyperplasia with obstructive sleep apnea and bruxism

  Satoshi Hamada; Kazuo Chin; Takefumi Hitomi; Toru Oga; Tomohiro Handa; Tomomasa Tuboi; Akio Niimi; Michiaki Mishima

  SLEEP AND BREATHING, Mar. 2012, Peer-reviewed

  
• Predictors of 5-year mortality in pulmonary Mycobacterium avium-intracellulare complex disease

  Y. Ito; T. Hirai; K. Maekawa; K. Fujita; S. Imai; S. Tatsumi; T. Handa; H. Matsumoto; S. Muro; A. Niimi; M. Mishima

  INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Mar. 2012, Peer-reviewed

  
• Predictors of 5-year mortality in pulmonary Mycobacterium avium-intracellulare complex disease

  Y. Ito; T. Hirai; K. Maekawa; K. Fujita; S. Imai; S. Tatsumi; T. Handa; H. Matsumoto; S. Muro; A. Niimi; M. Mishima

  INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Mar. 2012, Peer-reviewed

  
• Sarcoidosis Complicated with Major Pulmonary Artery Obstruction and Stenosis

  Koichi Hasegawa; Seiko Ohno; Mai Takada; Hiroshi Ogino; Shinsuke Shiotsu; Chieko Takumi; Noriya Hiraoka; Tomohiro Handa; Sonoko Nagai

  INTERNAL MEDICINE, 2012, Peer-reviewed

  
• ENDPOINTS FOR CLINICAL TRIALS OF SARCOIDOSIS

  R. P. Baughman; M. Drent; D. A. Culver; J. C. Grutters; T. Handa; M. Humbert; M. A. Judson; E. E. Lower; J. Mana; C. A. Pereira; A. Prasse; R. Sulica; D. Valyere; V. Vucinic; A. U. Wells

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 2012, Peer-reviewed

  
• A CD40 single-nucleotide polymorphism affects the lymphocyte profiles in the bronchoalveolar lavage of Japanese patients with sarcoidosis

  K. Tanizawa; T. Handa; S. Nagai; I. Ito; T. Kubo; Y. Ito; K. Watanabe; K. Aihara; M. Mishima; T. Izumi

  TISSUE ANTIGENS, Dec. 2011, Peer-reviewed

  
• HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody

  Kiminobu Tanizawa; Tomohiro Handa; Ran Nakashima; Takeshi Kubo; Yuji Hosono; Kizuku Watanabe; Kensaku Aihara; Toru Oga; Kazuo Chin; Sonoko Nagai; Tsuneyo Mimori; Michiaki Mishima

  RESPIRATORY MEDICINE, Sep. 2011, Peer-reviewed

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• Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias

  Kizuku Watanabe; Tomohiro Handa; Kiminobu Tanizawa; Yuji Hosono; Yoshio Taguchi; Satoshi Noma; Yoichiro Kobashi; Takeshi Kubo; Kensaku Aihara; Kazuo Chin; Sonoko Nagai; Tsuneyo Mimori; Michiaki Mishima

  RESPIRATORY MEDICINE, Aug. 2011, Peer-reviewed

  
• Comparison of biomarkers of subclinical lung injury in obstructive sleep apnea

  Kensaku Aihara; Toru Oga; Yuka Harada; Yuichi Chihara; Tomohiro Handa; Kiminobu Tanizawa; Kizuku Watanabe; Tomomasa Tsuboi; Takefumi Hitomi; Michiaki Mishima; Kazuo Chin

  RESPIRATORY MEDICINE, Jun. 2011, Peer-reviewed

  
• Validation of the japanese version of the sarcoidosis health questionnaire: A cross-sectional study

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Toru Oga; Takeshi Kubo; Yutaka Ito; Kizuku Watanabe; Kensaku Aihara; Kazuo Chin; Michiaki Mishima; Takateru Izumi

  HEALTH AND QUALITY OF LIFE OUTCOMES, May 2011, Peer-reviewed

  
• Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia

  Hitoshi Nakaji; Hisako Matsumoto; Akio Niimi; Tomohiro Handa; Isao Ito; Makiko Kanai; Hisako Tabata; Hiroaki Sakai; Yoichiro Kobashi; Yoshiro Mochizuki; Kazuo Chin; Michiaki Mishima

  NITRIC OXIDE-BIOLOGY AND CHEMISTRY, May 2011, Peer-reviewed

  
• Immediate Noninvasive Ventilation May Improve Mortality in Patients With Hepatopulmonary Syndrome After Liver Transplantation

  Yuichi Chihara; Hiroto Egawa; Tomomasa Tsuboi; Toru Oga; Tomohiro Handa; Kazuhiko Yamamoto; Michiaki Mishima; Koichi Tanaka; Shinji Uemoto; Kazuo Chin

  LIVER TRANSPLANTATION, Feb. 2011, Peer-reviewed

  
• Long-term Changes in Airway-Wall Thickness on Computed Tomography in Asthmatic Patients

  H. Matsumoto; A. Niimi; M. Takemura; T. Ueda; M. Yamaguchi; H. Matsuoka; M. Jinnai; T. Takeda; K. Otsuka; T. Oguma; T. Handa; T. Hirai; K. Chin; M. Mishima

  JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 2011, Peer-reviewed

  
• Efficacy of Blood-Patch Pleurodesis for Secondary Spontaneous Pneumothorax in Interstitial Lung Disease

  Kensaku Aihara; Tomohiro Handa; Sonoko Nagai; Kiminobu Tanizawa; Kizuku Watanabe; Yuka Harada; Yuichi Chihara; Takefumi Hitomi; Toru Oga; Tomomasa Tsuboi; Kazuo Chin; Michiaki Mishima

  INTERNAL MEDICINE, 2011, Peer-reviewed

  
• To Authors Reply: Invasive Mechanical Ventilation in Patients with Idiopathic Pulmonary Fibrosis or Idiopathic Non-Specific Interstitial Pneumonia

  Keisuke Tomii; Ryo Tachikawa; Kazuo Chin; Kimihiko Murase; Tomohiro Handa; Michiaki Mishima; Kyosuke Ishihara

  INTERNAL MEDICINE, 2011, Peer-reviewed

  
• Efficacy of Blood-Patch Pleurodesis for Secondary Spontaneous Pneumothorax in Interstitial Lung Disease

  Kensaku Aihara; Tomohiro Handa; Sonoko Nagai; Kiminobu Tanizawa; Kizuku Watanabe; Yuka Harada; Yuichi Chihara; Takefumi Hitomi; Toru Oga; Tomomasa Tsuboi; Kazuo Chin; Michiaki Mishima

  INTERNAL MEDICINE, 2011, Peer-reviewed

  
• Importance of the PaCO2 from 3 to 6 months after initiation of long-term non-invasive ventilation

  Tomomasa Tsuboi; Motoharu Ohi; Toru Oga; Kazuko Machida; Yuichi Chihara; Yuka Harada; Kenichi Takahashi; Kensuke Sumi; Tomohiro Handa; Akio Niimi; Michiaki Mishima; Kazuo Chin

  RESPIRATORY MEDICINE, Dec. 2010, Peer-reviewed

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• Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age

  Kensaku Aihara; Kazuo Chin; Toru Oga; Ken-ichi Takahashi; Takefumi Hitomi; Misa Takegami; Tomohiro Handa; Akio Niimi; Tomomasa Tsuboi; Michiaki Mishima

  HYPERTENSION RESEARCH, Oct. 2010, Peer-reviewed

  
• SIGNIFICANCE OF PLASMA NT-PROBNP LEVELS AS A BIOMARKER IN THE ASSESSMENT OF CARDIAC INVOLVEMENT AND PULMONARY HYPERTENSION IN PATIENTS WITH SARCOIDOSIS

  T. Handa; S. Nagai; S. Ueda; K. Chin; Y. Ito; K. Watanabe; K. Tanizawa; M. Tamaya; M. Mishima; T. Izumi

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Jul. 2010, Peer-reviewed

  
• CD24 GENE EXON 2 DIMORPHISM DOES NOT AFFECT DISEASE SUSCEPTIBILITY IN JAPANESE SARCOIDOSIS PATIENTS

  K. Tanizawa; T. Handa; S. Nagai; Y. Ito; K. Watanabe; K. Aihara; T. Izumi; M. Mishima

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Jul. 2010, Peer-reviewed

  
• Avoidance of Reintubation by Using Sedation during Noninvasive Positive Pressure Ventilation in a 3-Month-Old Infant with Postoperative Respiratory Failure

  Kizuku Watanabe; Kazuo Chin; Kenichi Takahashi; Masaya Murata; Hiraku Doi; Tomohiro Handa; Toru Oga; Tomomasa Tsuboi; Tadashi Ikeda; Tatsutoshi Nakahata; Ryuzo Sakata; Michiaki Mishima

  INTERNAL MEDICINE, 2010, Peer-reviewed

  
• Noninvasive Ventilation Improves the Outcome of Pulmonary Complications after Liver Resection

  Masato Narita; Kiminobu Tanizawa; Kazuo Chin; Iwao Ikai; Tomohiro Handa; Toru Oga; Akio Niimi; Tomomasa Tsuboi; Michiaki Mishima; Shinji Uemoto; Etsuro Hatano

  INTERNAL MEDICINE, 2010, Peer-reviewed

  
• Role of Non-invasive Ventilation in Managing Life-threatening Acute Exacerbation of Interstitial Pneumonia

  Keisuke Tomii; Ryo Tachikawa; Kazuo Chin; Kimihiko Murase; Tomohiro Handa; Michiaki Mishima; Kyosuke Ishihara

  INTERNAL MEDICINE, 2010, Peer-reviewed

  
• Effects of Obstructive Sleep Apnea with Intermittent Hypoxia on Platelet Aggregability

  Toru Oga; Kazuo Chin; Arata Tabuchi; Kensuke Sumi; Kenichi Takahashi; Tomohiro Handa; Kanako Takahashi; Ryoji Taniguchi; Hirokazu Kondo; Mitsunori Kawato; Takeshi Morimoto; Michiaki Mishima; Toru Kita; Hisanori Horiuchi

  JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Dec. 2009, Peer-reviewed

  
• LONG-TERM COMPLICATIONS AND PROGNOSIS OF CHRONIC BERYLLIUM DISEASE

  T. Handa; S. Nagai; M. Kitaichi; K. Chin; Y. Ito; T. Oga; K. Takahashi; K. Watanabe; M. Mishima; T. Izumi

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Jul. 2009, Peer-reviewed

  
• Clinical and radiographic features of lung involvements in primary Sjögren syndrome

  T. Handa; I. Ito; S. Nagai

  Japanese Journal of Chest Diseases, 2009, Peer-reviewed

  
• Computed Tomography Analysis of Airway Dimensions and Lung Density in Patients with Sarcoidosis

  Tomohiro Handa; Sonoko Nagai; Toyohiro Hirai; Kazuo Chin; Takeshi Kubo; Toru Oga; Akio Niimi; Hisako Matsumoto; Yutaka Ito; Kenichi Takahashi; Kizuku Watanabe; Takateru Izumi; Michiaki Mishima

  RESPIRATION, 2009, Peer-reviewed

  
• Outcome of sarcoidosis

  Sonoko Nagai; Tomohiro Handa; Yutaka Ito; Kousuke Ohta; Manabu Tamaya; Takateru Izumi

  CLINICS IN CHEST MEDICINE, Sep. 2008, Peer-reviewed

  
• Pharmacotherapy in patients with idiopathic pulmonary fibrosis

  S. Nagai; T. Handa; D. S. Kim

  Expert Opinion on Pharmacotherapy, Aug. 2008, Peer-reviewed

  
• Bronchoalveolar lavage in idiopathic interstitial lung diseases

  Sonoko Nagai; Tomohiro Handa; Yutaka Ito; Minoru Takeuchi; Takateru Izumi

  SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, Oct. 2007, Peer-reviewed

  
• HLA-DQB1*0602 allele is associated with splenomegaly in Japanese sarcoidosis

  H. Sato; S. Nagai; R. M. du Bois; T. Handa; Y. Suginoshita; K. Ohta; K. I. Welsh; T. Izumi

  JOURNAL OF INTERNAL MEDICINE, Oct. 2007, Peer-reviewed

  
• Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticator in patients with idiopathic pulmonary fibrosis

  Kunio Hamada; Sonoko Nagai; Shigeru Tanaka; Tomohiro Handa; Michio Shigematsau; Taishi Nagao; Michiaki Mishima; Masanori Kitaichi; Takateru Izumi

  CHEST, Mar. 2007, Peer-reviewed

  
• Incidence of pulmonary hypertension and its clinical relevance in patients with interstitial pneumonias: Comparison between idiopathic and collagen vascular disease associated interstitial pneumonias

  Tomohiro Handa; Sonoko Nagai; Shinji Miki; Seigen Ueda; Naoichiro Yukawa; Yasutaka Fushimi; Yutaka Ito; Kosuke Ohta; Tsuneyo Mimori; Michiaki Mishima; Takateru Izumi

  INTERNAL MEDICINE, 2007, Peer-reviewed

  
• Clinical and radiographic indices associated with airflow limitation in patients with sarcoidosis

  Tomohiro Handa; Sonoko Nagai; Yasataka Fushimi; Shinji Miki; Kosake Ohta; Akio Niimi

  CHEST, Dec. 2006, Peer-reviewed

  
• Incidence of pulmonary hypertension and its clinical relevance in patients with sarcoidosis

  T Handa; S Nagai; S Miki; Y Fushimi; K Ohta; M Mishima; T Izumi

  CHEST, May 2006, Peer-reviewed

  
• Multiple bone fractures found in a young sarcoidosis patient with long stable disease

  Tomohiro Handa; Sonoko Nagai; Isao Ito; Michio Shigematsu; Kunio Hamada; Masanori Kitaichi; Kosuke Ohta; Takateru Izumi; Michiaki Mishima

  Internal Medicine, 17 Jan. 2006, Peer-reviewed

  
• Significance of BALF findings for diagnosis of diffuse lung diseases

  S. Nagai; T. Handa

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Peer-reviewed

  
• Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema

  Ito, I; S Nagai; T Handa; S Muro; T Hirai; M Tsukino; M Mishima

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Dec. 2005, Peer-reviewed

  
• Patient characteristics and clinical features of Japanese sarcoidosis patients with low bronchoalveolar lavage CD4/CD8 ratios

  T Handa; S Nagai; M Shigematsu; RP Tabuena; M Takeuchi; T Mikuniya; K Hamada; T Izumi; M Mishima

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Jun. 2005, Peer-reviewed

  
• Long-term clinical course of a patient with anti PL-12 antibody accompanied by interstitial pneumonia and severe pulmonary hypertension

  T Handa; S Nagai; D Kawabata; T Nagao; M Takemura; M Kitaichi; T Izumi; T Mimori; M Mishima

  INTERNAL MEDICINE, Apr. 2005, Peer-reviewed

  
• Pulmonary manifestations of primary Sjogren's syndrome

  Ito, I; S Nagai; M Kitaichi; AG Nicholson; T Johkoh; S Noma; DS Kim; T Handa; T Izumi; M Mishima

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Mar. 2005, Peer-reviewed

  
• Sarcoidosis--immunological features and clinical issues

  T. Handa; S. Nagai; K. Ohta

  Nippon rinsho. Japanese journal of clinical medicine, 2005, Peer-reviewed

  
• Pulmonary manifestations of primary Sjogren's syndrome: a clinical, radiologic, and pathologic study.

  tIto I; Nagai S; Kitaichi M; Nicholson AG; Johkoh T; Noma S; Kim DS; Handa T; Izumi T; Mishima M

  Am J Respir Crit Care Med., 2005, Peer-reviewed

  
• Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis

  T Handa; S Nagai; Ito, I; R Tabuena; M Shigematsu; K Hamada; M Kitaichi; T Izumi; T Aoyama; J Toguchida; M Mishima

  RESPIRATION, 2005, Peer-reviewed

  
• Cell profiles of bronchoalveolar lavage fluid as prognosticators of idiopathic pulmonary fibrosis/usual interstitial pneumonia among Japanese patients

  RP Tabuena; S Nagai; T Tsutsumi; T Handa; T Minoru; T Mikuniya; M Shigematsu; K Hamada; T Izumi; M Mishima

  RESPIRATION, 2005, Peer-reviewed

  
• Nonspecific interstitial pneumonia: a real clinical entity?

  S Nagai; T Handa; R Tabuena; M Kitaichi; T Izumi

  CLINICS IN CHEST MEDICINE, Dec. 2004, Peer-reviewed

  
• Diabetes insipidius from neurosarcoidosis: Long-term follow-up for more than eight years

  RP Tabuena; S Nagai; T Handa; M Shigematsu; K Hamada; Ito, I; T Izumi; M Mishima; OP Sharma

  INTERNAL MEDICINE, Oct. 2004, Peer-reviewed

  
• Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis

  T Handa; S Nagai; Ito, I; M Shigematsu; K Hamada; M Kitaichi; T Izumi; M Mishima

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Oct. 2003, Peer-reviewed

  
• Glomerulonephritis induced by methicillin-sensitive Staphylococcus aureus infection

  Tomohiro Handa; Takahiko Ono; Hitomi Watanabe; Toshiya Takeda; Eri Muso; Toru Kita

  Clinical and Experimental Nephrology, Sep. 2003, Peer-reviewed

  
• Sarcoidosis with bilateral epididymal and testicular lesions

  T Handa; S Nagai; K Hamada; Ito, I; Y Hoshino; M Shigematsu; T Izumi; M Mishima

  INTERNAL MEDICINE, Jan. 2003, Peer-reviewed

  

Awards

• 01 Dec. 2023

  エルウィン・フォン・ベルツ賞２等賞
• 2005

  京都医師会, 京都医師会臨床医会　学術奨励賞銅賞
• 02 Nov. 2014

  Japan Society of Sarcoidosis and other Granulomatous disorders, 千葉保之・本間日臣記念賞

External funds: Kakenhi

• Donor and recipient peripheral blood telomere length and chronic lung allograft dysfunction in living donor lung transplantation.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55010:General surgery and pediatric surgery-related

  Kyoto University

  Handa Tomohiro

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  慢性移植肺機能不全;テロメア;生体肺移植;肺移植;遺伝子多型;アンギオテンシン転換酵素;慢性拒絶

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08925/
• Multicenter study for peripheral blood telomere length in patients with idiopathic pulmonary fibrosis

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Tomohiro Handa

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  特発性肺線維症;遺伝子変異;テロメア;ゲノム;老化;遺伝子;内科

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09612/
• Significance of sarcopenia in chronic respiratory diseases

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kiminobu Tanizawa

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  サルコペニア;慢性呼吸不全;間質性肺疾患;睡眠時無呼吸症候群;移植・再生医療;内科;臨床

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09534/
• Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mishima Michiaki

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  分子細胞呼吸学;iPS細胞;肺臓器再生;疾患モデリング;分子細胞呼吸器学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02537/
• Transcriptome analysis of pulmonary arterioles in interstitial pneumonia with pulmonary hypertension

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Tomohiro Handa

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  間質性肺疾患;肺高血圧症;メトリックスメタロプロテアーゼ;マトリックスメタロプロテアーゼ;間質性肺炎;マイクロアレイ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461187/
• Double-face culture system for application of alveolar epithelial cells induced from human iPS cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Ito Isao

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  iPS細胞;肺胞上皮細胞;気道上皮細胞;肺前駆細胞;ナノファイバー;呼吸器疾患;肺気腫;再生医学;線毛上皮細胞;血管内皮細胞;ES細胞;nanofiber;microfluidics

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293199/
• Researches using iPS cells on intractable respiratory diseases to elucidate their pathogenesis and develop novel therapy.

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  MICHIAKI MISHIMA

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  iPS細胞;ES細胞;II型肺胞上皮細胞;surfactant protein C;carboxypeptidase M;３次元培養;Hermansky-Pudlak 症候群;嚢胞性線維症;疾患特異iPS;肺胞上皮細胞;特発性間質性肺炎;若年性肺気腫;リンパ脈管筋腫症;疾患特異的iPS;I型肺胞上皮細胞;分化誘導;Birt-Hogg-Dube症候群

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22249031/
• メンデルランダム化解析による特発性肺線維症の治療ターゲットの探索

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53030:Respiratory medicine-related

  Kyoto University

  半田 知宏

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  メンデルランダム化;特発性肺線維症;プロテオーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K07652/

External funds: others

• 難治性疾患政策研究事業 (2022年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  研究分担者
• 難治性疾患政策研究事業 (2021年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  分担
• 特発性間質性肺炎における気管支肺胞洗浄液のトランスクリプトーム解析

  公益信託加藤記念難病研究助成基金

  From 2011, To 2012

  半田知宏
• （2020度分）

  難治性疾患政策研究事業

  From 01 Apr. 2020, To 31 Mar. 2021

  分担
• （2019年度分）

  難治性疾患等政策研究事業

  From 01 Apr. 2019, To 31 Mar. 2020

  分担
• （平成29年度分）

  難治性疾患等政策研究事業（難治性疾患政策研究事業）

  From 01 Apr. 2017, To 31 Mar. 2018

  分担
• （平成30年度分）

  難治性疾患等政策研究事業（難治性疾患政策研究事業）

  From 01 Apr. 2018, To 31 Mar. 2019

  分担

Education

Teaching subject(s)

• From Apr. 2015, To Mar. 2016

  Clinical Overview of Internal Medicine III

  Spring, 医学部（人間健康科学科）
• From Apr. 2016, To Mar. 2017

  Clinical Overview of Internal Medicine III

  Spring, 医学部（人間健康科学科）
• From Apr. 2017, To Mar. 2018

  Clinical Overview of Internal Medicine III

  Spring, 医学部（人間健康科学科）