Basic Information

Academic Degree

• 医学

Research History

• From Apr. 2024, To Present

  京都大学医学部附属病院, 腫瘍内科, 講師
• From Apr. 2019, To Present

  Kyoto University, 腫瘍内科, 助教
• From Apr. 2018, To Present

  Kyoto University, Hospital, 特定助教
• From Apr. 2017, To Mar. 2018

  Kyoto University, Hospital, 研究員
• From Apr. 2012, To Mar. 2013

  Kyoto University, Hospital, Gastroenterology and Hepatology, 医員
• From Apr. 2008, To Mar. 2012

  昭和大学横浜市北部病院, 消化器センター, 助教（員外）
• From Apr. 2004, To Mar. 2008

  いわき市立磐城共立病院, 内科, 初期研修医、後期研修医

Language of Instruction

• Japanese

ID,URL

• J-Global ID

  201801000167977500

researchmap URL

• https://researchmap.jp/yokoaki0821

Research

Research Topics, Overview of the research

• Research Topics

  生体内における外部刺激に伴うクローン選択に関する研究

Research Interests

• 消化管

Research Areas

• Life sciences, Genomics, origin of cancer

Papers

• 頭頸部表在癌の起源解析

  横山 顕礼; 廣橋 研志郎; 岸本 曜; 竹内 康英; 南口 早智子; 小川 誠司; 武藤 学; 垣内 伸之

  耳鼻咽喉科展望, Jul. 2024

  
• Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization.

  Yuki Kondo; Shinya Ohashi; Chikatoshi Katada; Yukie Nakai; Yoshihiro Yamamoto; Masashi Tamaoki; Osamu Kikuchi; Atsushi Yamada; Kenshiro Hirohashi; Yosuke Mitani; Shigeki Kataoka; Tomoki Saito; Trang H Nguyen Vu; Tomohiro Kondo; Yu Uneno; Tomohiko Sunami; Akira Yokoyama; Junichi Matsubara; Tomonari Matsuda; Seiji Naganuma; Kohei Oryu; Samuel Flashner; Masataka Shimonosono; Hiroshi Nakagawa; Manabu Muto

  Journal of gastroenterology, 06 Feb. 2025

  
• Comparison of Effective Imaging Modalities for Detecting Gastric Neoplasms: A Randomized 3-Arm Phase II Trial

  Tomohiro Kadota; Seiichiro Abe; Noriya Uedo; Hisashi Doyama; Yasuaki Furue; Manabu Muto; Satoru Nonaka; Hiroyuki Takamaru; Tatsuro Murano; Keiichiro Nakajo; Yasuhiro Tani; Yuki Okubo; Azusa Kawasaki; Naohiro Yoshida; Akinori Watanabe; Chikatoshi Katada; Masashi Tamaoki; Akira Yokoyama; Hideki Furuya; Takashi Ikeno; Masashi Wakabayashi; Tomonori Yano

  American Journal of Gastroenterology, 16 May 2024

  
• 食道扁平上皮癌の生物進化(Evolutionary Biology of esophageal squamous cell carcinoma)

  横山 顕礼; 平野 智紀; 石田 雄大; 菊池 理; 竹内 康英; 南口 早智子; 小川 誠司; 武藤 学; 垣内 伸之

  日本癌学会総会記事, Sep. 2023

  
• S状結腸ポリープとして認識された低異型度虫垂粘液腫瘍の一例

  西川 慧; 二階堂 光洋; 平松 由紀子; 清水 孝洋; 中西 祐貴; 内海 貴裕; 横山 顕礼; 武林 里沙; 青山 直樹; 我妻 信和; 妹尾 浩

  日本消化器内視鏡学会近畿支部例会プログラム・抄録集, Nov. 2023

  
• PDTは遠隔転移を抑制するか? 化学放射線療法後または放射線治療後の局所遺残再発食道癌に対する光線力学的療法と外科手術の検討

  玉置 将司; 横山 顕礼; 三谷 洋介; 堅田 親利; 野村 基雄; 錦織 達人; 角田 茂; 坂中 克行; 武藤 学

  日本レーザー医学会誌, Sep. 2022

  
• 領域外リンパ節転移薬物療法後CR症例:手術する?しない? 食道癌頸部単独再発に対する切除術の検討

  角田 茂; 岸本 曜; 錦織 達人; 久森 重夫; 坂中 克行; 野村 基雄; 玉置 将司; 横山 顕礼; 武藤 学; 小濱 和貴

  日本食道学会学術集会プログラム・抄録集, Sep. 2022

  
• S状結腸ポリープとして認識された低異型度虫垂粘液腫瘍の一例

  西川 慧; 二階堂 光洋; 平松 由紀子; 清水 孝洋; 中西 祐貴; 内海 貴裕; 横山 顕礼; 武林 里沙; 青山 直樹; 我妻 信和; 妹尾 浩

  日本消化器内視鏡学会近畿支部例会プログラム・抄録集, Nov. 2023

  
• Alcohol consumption, multiple Lugol-voiding lesions, and field cancerization

  Akira Yokoyama

  DEN Open, 2024

  
• "Endoscopic" adenoma detection rate as a quality indicator of colonoscopy: First report from the J-SCOUT study

  Akira Yokoyama

  Digestive Endoscopy, 2023

  
• Molecular mechanism of alcohol-related esophageal squamous cell carcinoma development

  Akira Yokoyama

  Cancer Science, 2023

  
• Pathogenic variants of homologous recombination repair-related genes in advanced pancreatic cancer and oxaliplatin-based chemotherapy: Prospective multicenter observational study

  Akira Yokoyama

  Journal of Clinical Oncology, 2022

  
• Feasibility study of a new tissue-based comprehensive genome profiling test

  Akira Yokoyama

  Annals of Oncology, 2022

  
• Clinical safety of nivolumab 480 mg once every 4 weeks

  Akira Yokoyama

  Annals of Oncology, 2022

  
• Tissue remodeling by positively selected clones in esophagus and colon

  Akira Yokoyama

  Cancer Science, 2021

  
• Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals novel cancer vulnerability

  Akira Yokoyama

  Cancer Science, 2021

  
• Is it proper to use non-magnified narrow-band imaging for esophageal neoplasia screening? Japanese single-center, prospective study

  Akira Yokoyama

  Digestive Endoscopy, 2012

  
• The Optimal Staining Regimen for Colonic Endocytoscopy Could Be 1.0% Methylene Blue for 3 Minutes: An In Vivo Pilot Study

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2012

  
• Additional Diagnostic Value of Endocytoscopy to Magnifying Chromoendoscopy for Predicting Massively Invasive Colorectal Cancers: A Prospective Comparative Pilot Study

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2012

  
• Novel narrow-band imaging magnifying endoscopic classification for early gastric cancer

  Akira Yokoyama

  Digestive and Liver Disease, 2010

  
• NBI Magnifying Endoscopic Classification for Early Gastric Cancer; Particularly Focusing on Micro-Vascular Pattern and Surface Glandular Structure

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2010

  
• Can Optical Biopsy Replace Pathology? In Vivo Endocytoscopic Evaluation of Gastric Cancer

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2010

  
• The Usefulness of Carbon Dioxide Insufflations for Single Balloon Panenteroscopy

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2009

  
• In Vivo Observation of Living Cancer Cells in the Upper GI Tract: Endocytoscopic Atypia (ECA) Classification

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2009

  
• Prevention of Subsequent Stricture; Circumferential Endoscopic Resection for Wide Spread Squamous Cell Carcinoma in the Esophagus

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2009

  
• Novel Magnifying Endoscopic Classification for Early Gastric Cancer with Narrow Band Imaging System; Particularly Focusing On Micro-Vascular Pattern and Surface Glandular Structure

  Akira Yokoyama

  Gastrointestinal Endoscopy, 2009

  
• コンピュータ診断支援システムが見逃しを防いだ大腸ポリープの検討

  山添 紗希; 中西 祐貴; 内海 貴裕; 我妻 信和; 樋口 浩和; 黄 宣輔; 奥野 岳; 水越 健太; 山川 剛; 夜久 大晃; 熊谷 健; 平松 由紀子; 二階堂 光洋; 清水 孝洋; 横山 顕礼; 妹尾 浩

  日本消化器病学会近畿支部例会プログラム・抄録集, Feb. 2022

  
• コンピュータ診断支援システムが見逃しを防いだ大腸ポリープの検討

  山添 紗希; 中西 祐貴; 内海 貴裕; 我妻 信和; 樋口 浩和; 黄 宣輔; 奥野 岳; 水越 健太; 山川 剛; 夜久 大晃; 熊谷 健; 平松 由紀子; 二階堂 光洋; 清水 孝洋; 横山 顕礼; 妹尾 浩

  日本消化器病学会近畿支部例会プログラム・抄録集, Feb. 2022

  
• Successful Management of Malignant Pericarditis using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma: A Case Report.

  Yu Uneno; Motoo Nomura; Taisuke Hosokai; Yoshinosuke Kurakake; Masayuki Fuki; Hiroki Shiomi; Yasuhide Takeuchi; Masashi Tamaoki; Akira Yokoyama; Chikatoshi Katada; Manabu Muto

  Internal medicine (Tokyo, Japan), 19 Jul. 2023

  
• Successful Management of Malignant Pericarditis using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma: A Case Report

  Yu Uneno; Motoo Nomura; Taisuke Hosokai; Yoshinosuke Kurakake; Masayuki Fuki; Hiroki Shiomi; Yasuhide Takeuchi; Masashi Tamaoki; Akira Yokoyama; Chikatoshi Katada; Manabu Muto

  Internal Medicine, 2023

  
• Timing of the infusion of nivolumab for patients with recurrent or metastatic squamous cell carcinoma of the esophagus influences its efficacy.

  Motoo Nomura; Taisuke Hosokai; Masashi Tamaoki; Akira Yokoyama; Shigemi Matsumoto; Manabu Muto

  Esophagus : official journal of the Japan Esophageal Society, 24 Apr. 2023

  
• Association between homologous recombination gene variants and efficacy of oxaliplatin-based chemotherapy in advanced pancreatic cancer: prospective multicenter observational study.

  Tomohiro Kondo; Masashi Kanai; Junichi Matsubara; Daisuke Yamaguchi; Takashi Ura; Tadayuki Kou; Toshinao Itani; Motoo Nomura; Taro Funakoshi; Akira Yokoyama; Keitaro Doi; Masashi Tamaoki; Michio Yoshimura; Norimitsu Uza; Takahiro Yamada; Toshihiko Masui; Sachiko Minamiguchi; Shigemi Matsumoto; Hideki Ishikawa; Manabu Muto

  Medical oncology (Northwood, London, England), 11 Apr. 2023

  
• 多発ヨード不染帯を有する食道早期癌内視鏡切除後患者に対するTS-1療法の食道内多発癌抑制効果に関する検討

  玉置 将司; 堀松 高博; 横山 顕礼; 天沼 裕介; 宮本 心一; 山田 敦; 野村 基雄; 船越 真木子; 松本 繁巳; 大橋 真也; 青山 育雄; 石川 秀樹; 武藤 学

  日本消化管学会雑誌, Jan. 2020, Peer-reviewed

  
• The landscape of genetic aberrations in myxofibrosarcoma.

  Yasuhide Takeuchi; Kenichi Yoshida; Adriane Halik; Annegret Kunitz; Hiromichi Suzuki; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoshikage Inoue; Tomonori Hirano; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Berit Maria Pfitzner; Lars Bullinger; Masahiro Hirata; Keita Jinnouchi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Takeshi Okamoto; Hironori Haga; Seishi Ogawa; Frederik Damm

  International journal of cancer, 29 Apr. 2022

  Access this paper :

  
• 【消化管症候群(第3版)-その他の消化管疾患を含めて-】空腸、回腸、盲腸、結腸、直腸(下) 腫瘍 大腸腫瘍 悪性腫瘍 大腸腺扁平上皮癌

  内海 貴裕; 横山 顕礼; 堀松 高博

  日本臨床, May 2020

  
• The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy

  Hidenari Hirata; Atsushi Niida; Nobuyuki Kakiuchi; Ryutaro Uchi; Keishi Sugimachi; Takaaki Masuda; Tomoko Saito; Shun-Ichiro Kageyama; Yushi Motomura; Shuhei Ito; Tadamasa Yoshitake; Daisuke Tsurumaru; Yusuke Nishimuta; Akira Yokoyama; Takanori Hasegawa; Kenichi Chiba; Yuichi Shiraishi; Junyan Du; Fumihito Miura; Masaru Morita; Yasushi Toh; Masakazu Hirakawa; Yoshiyuki Shioyama; Takashi Ito; Tetsuo Akimoto; Satoru Miyano; Tatsuhiro Shibata; Masaki Mori; Yutaka Suzuki; Seishi Ogawa; Kousei Ishigami; Koshi Mimori

  Cancer Research, 01 Oct. 2021

  
• Molecular classification and diagnostics of upper urinary tract urothelial carcinoma.

  Yoichi Fujii; Yusuke Sato; Hiromichi Suzuki; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Andrew T Lenis; Shigekatsu Maekawa; Akira Yokoyama; Yasuhide Takeuchi; Yoshikage Inoue; Yotaro Ochi; Yusuke Shiozawa; Kosuke Aoki; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yasuhito Nannya; Hideki Makishima; Jimpei Miyakawa; Taketo Kawai; Teppei Morikawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Genta Nagae; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Tohru Nakagawa; Masashi Fukayama; Tetsuo Ushiku; Hiroyuki Aburatani; Satoru Miyano; Jonathan A Coleman; Yukio Homma; David B Solit; Haruki Kume; Seishi Ogawa

  Cancer cell, 14 Jun. 2021

  Access this paper :

  
• Repeated talaporfin sodium photodynamic therapy for esophageal cancer: safety and efficacy

  Masashi Tamaoki; Akira Yokoyama; Takahiro Horimatsu; Kenshiro Hirohashi; Yusuke Amanuma; Hirokazu Higuchi; Yosuke Mitani; Masahiro Yoshioka; Shinya Ohashi; Manabu Muto

  Esophagus, 09 Jun. 2021

  Access this paper :

  
• Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations.

  Mitsuhiro Nikaido; Nobuyuki Kakiuchi; Shin'ichi Miyamoto; Tomonori Hirano; Yasuhide Takeuchi; Taro Funakoshi; Akira Yokoyama; Tatsuki Ogasawara; Yoshihiro Yamamoto; Atsushi Yamada; Takeshi Setoyama; Takahiro Shimizu; Yukari Kato; Suguru Uose; Takaki Sakurai; Sachiko Minamiguchi; Kazutaka Obama; Yoshiharu Sakai; Manabu Muto; Tsutomu Chiba; Seishi Ogawa; Hiroshi Seno

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 07 May 2021

  
• Comprehensive genomic profiling for patients with chemotherapy-naïve advanced cancer.

  Tomohiro Kondo; Junichi Matsubara; Pham Nguyen Quy; Keita Fukuyama; Motoo Nomura; Taro Funakoshi; Keitaro Doi; Yuichi Sakamori; Masahiro Yoshioka; Akira Yokoyama; Masashi Tamaoki; Tadayuki Kou; Kenshiro Hirohashi; Atsushi Yamada; Yoshihiro Yamamoto; Sachiko Minamiguchi; Masakazu Nishigaki; Takahiro Yamada; Masashi Kanai; Shigemi Matsumoto; Manabu Muto

  Cancer science, Jan. 2021

  Access this paper :

  
• Qualitative and Quantitative Analysis of Posttreatment Strategy After Endoscopic Resection for Patients with T1 Colorectal Cancer at High Risk of Lymph Node Metastasis.

  Yoshitaka Nishikawa; Takahiro Horimatsu; Daisuke Nishizaki; Ayako Kohno; Akira Yokoyama; Masahiro Yoshioka; Koya Hida; Katsuyuki Sakanaka; Sachiko Minamiguchi; Hiroshi Seno; Yoshiharu Sakai; Takeo Nakayama

  Journal of gastrointestinal cancer, Mar. 2020, Peer-reviewed

  
• Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

  Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M. Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa

  Nature, 09 Jan. 2020, Peer-reviewed

  Access this paper :

  
• 発がん過程におけるゲノムと環境因子の相互作用 加齢に伴う食道上皮の遺伝子変異クローンによる再構築(Interactions between genomic and environmental factors during carcinogenesis Age-related remodeling of esophageal epithelia by mutated cancer drivers)

  横山 顕礼; 垣内 伸之; 吉里 哲一; 南谷 泰仁; 竹内 康英; 塩澤 祐介; 牧島 秀樹; 角田 茂; 眞田 昌; 宮野 悟; 武藤 学; 小川 誠司

  日本癌学会総会記事, Sep. 2019

  
• 発がん過程におけるゲノムと環境因子の相互作用 加齢に伴う食道上皮の遺伝子変異クローンによる再構築(Interactions between genomic and environmental factors during carcinogenesis Age-related remodeling of esophageal epithelia by mutated cancer drivers)

  横山 顕礼; 垣内 伸之; 吉里 哲一; 南谷 泰仁; 竹内 康英; 塩澤 祐介; 牧島 秀樹; 角田 茂; 眞田 昌; 宮野 悟; 武藤 学; 小川 誠司

  日本癌学会総会記事, Sep. 2019, Peer-reviewed

  
• Genetic analysis of pancreatic neuroendocrine neoplasms grade 3

  Kakiuchi Nobuyuki; Yoshida Kenichi; Shiozawa Yusuke; Yokoyama Akira; Kataoka Keisuke; Inoue Yoshikage; Takeuchi Yasuhide; Hirano Tomonori; Fujii Yoichi; Ueno Hiroo; Hijioka Susumu; Mizuno Nobumasa; Hosoda Waki; Yatabe Yasushi; Chiba Kenichi; Tanaka Hiroko; Shiraishi Yuichi; Miyano Satoru; Masui Toshihiko; Uemoto Shinji; Yoshizawa Akihiko; Haga Hironori; Uza Norimitsu; Seno Hiroshi; Kodama Yuzo; Ogawa Seishi

  CANCER RESEARCH, Jul. 2019, Peer-reviewed

  
• Genetic analysis of metachronous pancreatic cancers

  Tomonori Hirano; Kakiuchi Nobuyuki; Takeuchi Yasuhide; Inoue Yoshikage; Nishimura Tomomi; Fujii Yoichi; Yokoyama Akira; Makishima Hideki; Masui Toshihiko; Uemoto Shinji; Minamiguchi Sachiko; Haga Hironori; Chiba Kenichi; Tanaka Hiroko; Shiraishi Yuichi; Miyano Satoru; Uza Norimitsu; Kodama Yuzo; Seno Hiroshi; Chiba Tsutomu; Ogawa Seishi

  CANCER RESEARCH, Jul. 2019, Peer-reviewed

  
• Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

  Soo Ki Kim; Haruhiko Takeda; Atsushi Takai; Tomonori Matsumoto; Nobuyuki Kakiuchi; Akira Yokoyama; Kenichi Yoshida; Toshimi Kaido; Shinji Uemoto; Sachiko Minamiguchi; Hironori Haga; Yuichi Shiraishi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa; Hiroyuki Marusawa

  Journal of gastroenterology, Jul. 2019, Peer-reviewed

  
• Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.

  Taro Funakoshi; Shin'ichi Miyamoto; Nobuyuki Kakiuchi; Mitsuhiro Nikaido; Takeshi Setoyama; Akira Yokoyama; Takahiro Horimatsu; Atsushi Yamada; Masako Torishima; Shinji Kosugi; Hidetaka Yamada; Haruhiko Sugimura; Hironori Haga; Yoshiharu Sakai; Seishi Ogawa; Hiroshi Seno; Manabu Muto; Tsutomu Chiba

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Jul. 2019, Peer-reviewed

  
• 食道癌に対するゲノム医療の可能性と方向性 加齢に伴う正常食道組織の遺伝子異常とがん化のメカニズム

  横山 顕礼; 垣内 伸之; 吉里 哲一; 竹内 康英; 角田 茂; 南口 早智子; 三森 功士; 宮野 悟; 武藤 学; 小川 誠司

  日本食道学会学術集会プログラム・抄録集, Jun. 2019, Peer-reviewed

  
• Age-related remodelling of oesophageal epithelia by mutated cancer drivers.

  Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Ki Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Yoshitaka Nishikawa; Yusuke Amanuma; Shinya Ohashi; Ikuo Aoyama; Takahiro Horimatsu; Shin'ichi Miyamoto; Shigeru Tsunoda; Yoshiharu Sakai; Maiko Narahara; J B Brown; Yoshitaka Sato; Genta Sawada; Koshi Mimori; Sachiko Minamiguchi; Hironori Haga; Hiroshi Seno; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa

  Nature, Jan. 2019, Peer-reviewed

  
• 食道病理学的正常部の上皮には、食道癌ドライバー遺伝子によって年齢依存のリモデリングが生じる(Age-related remodeling of apparently normal esophageal epithelia by common cancer drivers)

  横山 顕礼; 吉里 哲一; 垣内 伸之; 南谷 泰仁; 鈴木 啓道; 塩澤 裕介; 竹内 康英; 牧島 秀樹; 角田 茂; 真田 昌; 宮野 悟; 武藤 学; 小川 誠司

  日本癌学会総会記事, Sep. 2018, Peer-reviewed

  
• Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma

  Akira Yokoyama

  Cancer Research, 2018, Peer-reviewed

  
• Paraneoplastic limbic encephalitis in a human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy: A case report and literature review

  Yu Uneno; Akira Yokoyama; Yoshitaka Nishikawa; Taro Funakoshi; Yoshinao Ozaki; Ikuo Aoyama; Kiichiro Baba; Daisuke Yamaguchi; Shuko Morita; Yukiko Mori; Masashi Kanai; Hisanori Kinoshita; Takeshi Inoue; Nobukatsu Sawamoto; Riki Matsumoto; Shigemi Matsumoto; Manabu Muto

  Internal Medicine, 2016, Invited

  Access this paper :

  

Misc.

• How does aging contribute to cancer?

  Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Manabu Muto; Seishi Ogawa

  Japanese Journal of Cancer and Chemotherapy, 01 Sep. 2020

  
• Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability

  Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Akaki Kotaro; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Tomonori Hirano; Yasuhide Takeuchi; Hiroyuki Miyoshi; Yoshiharu Sakai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa

  CANCER RESEARCH, Aug. 2020

  
• Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma

  Yasuhide Takeuchi; Annegret Kunitz; Adriane Halik; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoshikage Inoue; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa

  CANCER RESEARCH, Aug. 2020

  
• Genetic analysis of metachronous pancreatic cancers

  Hirano Tomonori; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Yoshikage Inoue; Tomomi Nishimura; Yoichi Fujii; Akira Yokoyama; Hideki Makishima; Toshihiko Masui; Shinji Uemoto; Sachiko Minamiguchi; Hironori Haga; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Norimitsu Uza; Yuzo Kodama; Hiroshi Seno; Seishi Ogawa

  CANCER RESEARCH, Aug. 2020

  
• Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability

  Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Teppei Shimamura; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa

  CANCER RESEARCH, Jul. 2019

  
• Chronology and risk dependence of age-related remodelling of oesophageal epithelia

  Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M. Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Shinya Ohashi; Shin'ichi Miyamoto; Shigeru Tsunoda; Koshi Mimori; Sachiko Minamiguchi; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa

  CANCER RESEARCH, Jul. 2019

  
• 潰瘍性大腸炎における上皮細胞の陽性選択

  垣内伸之; 垣内伸之; 内野基; 木原多佳子; 赤木宏太朗; 井上善景; 長山聡; 横山顕礼; 平野智紀; 平野智紀; 竹内康英; 竹内康英; 越智陽太郎; 塩澤裕介; 片岡圭亮; 中川正宏; 依田成玄; 南谷泰仁; 牧島秀樹; 白石友一; 千葉健一; 真田昌; 三好弘之; 坂井義治; 桜井孝規; 羽賀博典; 廣田誠一; 池内浩基; 竹内理; 宮野悟; 妹尾浩; 小川誠司

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  
• Age-related remodeling of apparently normal esophageal epithelia by common cancer drivers

  Akira Yokoyama; Tetsuichi Yoshizato; Nobuyuki Kakiuchi; Yasuhito Nannya; Hiromichi Suzuki; Yusuke Shiozawa; Yasuhide Takeuchi; Hideki Makishima; Shigeru Tsunoda; Masashi Sanada; Satoru Miyano; Manabu Muto; Seishi Ogawa

  CANCER SCIENCE, Dec. 2018

  
• Comprehensive analysis of genetic alterations and intratumor heterogeneity in myxofibrosarcoma

  Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoichi Fujii; Tetsuichi Yoshizato; Kosuke Aoki; Keisuke Kataoka; Yasuhito Nannya; Yuichi Shiraishi; Teppei Shimamura; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa

  CANCER RESEARCH, Jul. 2018

  
• Differential role of mutations in clonal evolution of esophageal squamous cell mucosa

  Yokoyama Akira; Hiromichi Suzuki; Tetsuichi Yoshizato; Nobuyuki Kakiuchi; Yuusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Yasuhide Takeuchi; Shigeru Tsunonoda; Masashi Sanada; Satoru Miyano; Manabu Muto; Seishi Ogawa

  CANCER SCIENCE, Jan. 2018

  
• アルコール・タバコの慢性暴露による食道扁平上皮では、癌部と非癌部で異なるクローン選択を来す

  横山 顕礼; 鈴木 啓道; 吉里 哲一; 垣内 伸之; 塩澤 裕介; 佐藤 悠佑; 青木 恒介; 竹内 康英; 角田 茂; 真田 昌; 宮野 悟; 武藤 学; 小川 誠司

  日本癌学会総会記事, Sep. 2017

  
• 慢性的なアルコール・タバコの暴露が関与する食道発癌メカニズム

  横山 顕礼; 垣内 伸之; 鈴木 啓道; 吉里 哲一; 青木 恒一; 竹内 康英; 天沼 裕介; 西川 佳孝; 大橋 真也; 青山 育雄; 堀松 高博; 宮本 心一; 角田 茂; 南口 早智子; 武藤 学; 小川 誠司

  日本消化器病学会雑誌, Sep. 2017

  
• The genetic aberrations in carcinogenic sequence of colitis-associated cancer

  Nobuyuki Kakiuchi; Kenichi Yoshida; Yusuke Shiozawa; Akira Yokoyama; Keisuke Kataoka; Yoshikage Inoue; Yasuhide Takeuchi; Yasunori Kogure; Ayana Kon; Masahiro Nakagawa; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Kenji Kawada; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Hiroshi Nakase; Motoi Uchino; Hiroki Ikeuchi; Takako Kihara; Seiichi Hirota; Takahiro Horimatsu; Minoru Matsuura; Hiroyuki Marusawa; Hiroshi Seno; Seishi Ogawa

  CANCER RESEARCH, Jul. 2017

  
• Comprehensive genetic analysis of myxofibrosarcoma and comparison with other soft tissue sarcomas

  Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Teppei Shimamura; Kenichi Chiba; Hiroko Tanaka; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Hideki Makishima; Hironori Haga; Satoru Miyano; Frederik Damm; Seishi Ogawa

  CANCER RESEARCH, Jul. 2017

  
• Differential role of mutations in clonal evolution in esophageal mucosa at risk for cancer

  Akira Yokoyama; Hiromichi Suzuki; Tetsuichi Yoshizato; Yuusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Yoichi Fujii; Hideki Makishima; Kenichi Yoshida; Keisuke Kataoka; Yaichi Shiraishi; Masashi Sanada; Shigeru Tsunoda; Sachiko Minamiguchi; Satoru Miyano; Manabu Muto; Seishi Ogawa

  CANCER RESEARCH, Jul. 2017

  
• 食道癌ハイリスク群の食道粘膜では、遺伝子変異のclonal evolutionは癌化において異なった役割を担う

  横山 顕礼; 鈴木 啓道; 吉里 哲一; 塩澤 祐介; 佐藤 悠佑; 青木 恒介; 垣内 伸之; 竹内 康英; 角田 茂; 真田 昌; 宮野 悟; 武藤 学; 小川 誠司

  日本癌学会総会記事, Oct. 2016

  
• Clonal evolution in noncancerous esophageal mucosa in normal and cancer-bearing individuals

  Akira Yokoyama; Hiromichi Suzuki; Tetsuichi Yoshizato; Kosuke Aoki; Yusuke Shiozawa; Youichi Fujii; Yusuke Sato; Nobuyuki Kakiuchi; Sugi Kin; Keisuke Kataoka; Kenichi Yoshida; Hideki Makishinna; Yusuke Annanuma; Shinya Oohashi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; J. B. Brown; Masashi Sanada; Shigeru Tsunoda; Sachiko Minamiguchi; Yoshiharu Sakai; Hironori Haga; Tsutonne Chiba; Satoru Miyano; Manabu Muto; Seishi Ogawa

  CANCER RESEARCH, Jul. 2016

  
• Notch3過剰発現による食道扁平上皮分化誘導は腫瘍造成能及び5FU抵抗性を抑制する

  菊池 理; 大橋 真也; 天沼 裕介; 横山 顕礼; 宮本 心一; 松本 繁巳; 武藤 学

  日本食道学会学術集会プログラム・抄録集, Jul. 2015

  
• 呼気を利用した食道癌のリスク判別法の開発

  青山 育雄; 武藤 学; 鶴巻 美穂子; 中井 由起恵; 江副 康正; 森田 周子; 堀松 高博; 大橋 真也; 横山 顕礼; 宮本 心一

  日本食道学会学術集会プログラム・抄録集, Jul. 2014

  
• 当院における頭頸部表在癌の治療成績

  森田 周子; 武藤 学; 楯谷 一郎; 横山 顕礼; 青山 育雄; 堀松 高博; 江副 康正; 宮本 心一; 千葉 勤

  日本食道学会学術集会プログラム・抄録集, Jul. 2014

  
• 食道癌化学療法(5FU/Cisplatin及び5FU/Nedaplatin)における低Na血症の解析

  OZAKI YOSHINAO; EZOE YASUMASA; AOYAMA IKUO; YOKOYAMA KENREI; HORIMATSU TAKAHIRO; MORITA SHUKO; MIYAMOTO SHIN'ICHI; MUTO MANABU

  日本臨床腫瘍学会学術集会(CD-ROM), 2013

  
• 炎症性変化と鑑別に迷う中咽頭上皮内癌の1例

  YOKOYAMA AKIRA; MORITA SHUKO; MUTO MANABU; SETOYAMA TAKESHI; AMANUMA YUSUKE; OZAKI YOSHINAO; AOYAMA IKUO; HORIMATSU TAKAHIRO; EZOE YASUMASA; MIYAMOTO SHIN'ICHI; CHIBA TSUTOMU; TATEYA ICHIRO; MINAMIGUCHI SACHIKO

  耳鼻咽喉科展望, 15 Dec. 2012

  
• 食道表在癌―症例から学ぶ診断と治療戦略〔食道表在癌診断と治療の実際〕深達度MMと診断し,内視鏡切除術を選択した食道表在癌―0‐II a,pMM

  MORITA SHUKO; YOKOYAMA AKIRA; SETOYAMA KEN; AMANUMA YUSUKE; OZAKI YOSHINAO; AOYAMA IKUO; HORIMATSU TAKAHIRO; EZOE YASUMASA; MIYAMOTO SHIN'ICHI; MUTO MANABU; CHIBA TSUTOMU

  消化器内視鏡, 25 Aug. 2012

  

External funds: Kakenhi

• Elucidation of genomic abnormalities in normal esophageal epithelium associated with radiation therapy and chemotherapy

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Akira Yokoyama

  From 30 Jul. 2020, To 31 Mar. 2023, Project Closed

  食道がん;フィールドがん化;放射線療法;飲酒;喫煙;ゲノム異常;食道扁平上皮;2次性発がん;網羅的ゲノム解析;化学療法;食道扁平上皮がん;食道;ゲノム解析;放射線

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21574/
• Early genomic aberrations in esophageal carcinogenesis: Comprehensive genomic analysis of multiple lugol voiding lesions

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53010:Gastroenterology-related

  Kyoto University

  Akira Yokoyama

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  食道がん;飲酒;喫煙;ヨード不染;がんの起源;食道扁平上皮がん;上皮内腫瘍;ヨード不染色;網羅的ゲノム解析;食道扁平上皮;ゲノム解析;老化;食道扁平上皮癌;リスク因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03660/
• 人工知能(AI)による咽喉頭癌の術中切除範囲決定支援システムの開発

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56050:Otorhinolaryngology-related

  Fujita Health University

  楯谷 一郎

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  人工知能;咽頭癌;喉頭癌;内視鏡;鏡視下咽頭悪性腫瘍手術;咽喉頭癌;内視鏡診断

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09677/
• ヒト食道上皮細胞の形質転換メカニズムの解明

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 50:Oncology and related fields

  Kyoto University

  垣内 伸之

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  食道癌;クローン進化;食道がん;発がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19457/
• アルコール長期曝露による正常食道上皮に生じる変異負荷や微小環境変化の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53010:Gastroenterology-related

  Kyoto University

  横山 顕礼

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  アルコール発がん;食道がん;遺伝子変異;遺伝子多型

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02439/