Basic Information

Academic Degree

• 博士（医学）(筑波大学)

ID,URL

• J-Global ID

  200901028486302917

researchmap URL

• https://researchmap.jp/read0209419

Research

Research Interests

• クラススイッチ

Research Areas

• Life sciences, Medical biochemistry

Papers

• Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase

  Maki Kobayashi; Hiroyuki Wakaguri; Masakazu Shimizu; Koichiro Higasa; Fumihiko Matsuda; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 24 Apr. 2023, Peer-reviewed, Lead author, Corresponding author

  
• Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification

  Wajid Amin; Shoki Nishio; Tasuku Honjo; Maki Kobayashi

  International Immunology, 22 Apr. 2023, Peer-reviewed, Lead author, Last author

  
• Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells

  Afzal Husain; Nasim Begum; Maki Kobayashi; Tasuku Honjo

  BIO-PROTOCOL, 2020

  
• Erratum: GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene (Molecular and Cellular Biology (2005) 25, 16 (7005-7020))

  Maki Kobayashi-Osaki; Osamu Ohneda; Norio Suzuki; Naoko Minegishi; Tomomasa Yokomizo; Satoru Takahashi; Kim-Chew Lim; James Douglas Engel; Masayuki Yamamoto

  Molecular and Cellular Biology, Nov. 2005, Peer-reviewed

  
• SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

  Afzal Husain; Jianliang Xu; Hodaka Fujii; Mikiyo Nakata; Maki Kobayashi; Ji‐Yang Wang; Jan Rehwinkel; Tasuku Honjo; Nasim A Begum

  The EMBO Journal, 03 Aug. 2020

  
• RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase

  Ziwei Yin; Maki Kobayashi; Wenjun Hu; Koichi Higashi; Nasim A. Begum; Ken Kurokawa; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 26 May 2020, Peer-reviewed, Lead author

  
• Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene

  Helena Islam; Maki Kobayashi; Tasuku Honjo

  International Immunology, 30 Jul. 2019, Peer-reviewed, Lead author

  
• Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

  Azza Al Ismail; Afzal Husain; Maki Kobayashi; Tasuku Honjo; Nasim A Begum

  International Immunology, 30 Dec. 2017

  
• The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR

  Maki Kobayashi; Misao Takemoto; Tasuku Honjo

  DNA Repair, May 2017, Lead author

  
• Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

  Afzal Husain; Nasim A. Begum; Takako Taniguchi; Hisaaki Taniguchi; Maki Kobayashi; Tasuku Honjo

  Nature Communications, Apr. 2016

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• LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2

  Miki Takeuchi; Yuji Fuse; Mana Watanabe; Christina-Sylvia Andrea; Miho Takeuchi; Hitomi Nakajima; Ken Ohashi; Hiroshi Kaneko; Maki Kobayashi-Osaki; Masayuki Yamamoto; Makoto Kobayashi

  Proceedings of the National Academy of Sciences, 10 Nov. 2015

  
• Molecular Mechanisms of AID Function

  Nasim A. Begum; Hitoshi Nagaoka; Maki Kobayashi; Tasuku Honjo

  Molecular Biology of B Cells, 2015

  
• APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination

  Jianliang Xu; Afzal Husain; Wenjun Hu; Tasuku Honjo; Maki Kobayashi

  Proceedings of the National Academy of Sciences, 02 Dec. 2014, Last author

  
• Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models

  Tung Nguyen; Jianliang Xu; Shunsuke Chikuma; Hiroshi Hiai; Kazuo Kinoshita; Kyoji Moriya; Kazuhiko Koike; Gian Paolo Marcuzzi; Herbert Pfister; Tasuku Honjo; Maki Kobayashi

  International Immunology, Jul. 2014, Last author

  
• C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

  Somayeh Sabouri; Maki Kobayashi; Nasim A. Begum; Jianliang Xu; Kouji Hirota; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 11 Feb. 2014

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• GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation

  Mikiko Suzuki; Maki Kobayashi-Osaki; Shuichi Tsutsumi; Xiaoqing Pan; Shin'ya Ohmori; Jun Takai; Takashi Moriguchi; Osamu Ohneda; Kinuko Ohneda; Ritsuko Shimizu; Yasuharu Kanki; Tatsuhiko Kodama; Hiroyuki Aburatani; Masayuki Yamamoto

  Genes to Cells, Nov. 2013

  
• In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression

  Le Thi Huong; Maki Kobayashi; Mikiyo Nakata; Go Shioi; Hitoshi Miyachi; Tasuku Honjo; Hitoshi Nagaoka

  PLoS ONE, 16 Apr. 2013, Peer-reviewed

  
• An Evolutionary View of the Mechanism for Immune and Genome Diversity

  Lucia Kato; Andre Stanlie; Nasim A. Begum; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo

  JOURNAL OF IMMUNOLOGY, Apr. 2012, Peer-reviewed

  
• The AID dilemma: infection, or cancer?

  HonjoTasuku; Kobayashi Maki; Begum Nasim; Kotani Ai; Sabouri Somayeh; Nagaoka Hitoshi

  Advances in cancer research, 2012, Peer-reviewed

  
• The AID Dilemma: Infection, or Cancer?

  Tasuku Honjo; Maki Kobayashi; Nasim Begum; Ai Kotani; Somayeh Sabouri; Hitoshi Nagaoka

  ADVANCES IN CANCER RESEARCH, VOL 113, 2012, Peer-reviewed

  
• Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

  M. Kobayashi; Z. Sabouri; S. Sabouri; Y. Kitawaki; Y. Pommier; T. Abe; H. Kiyonari; T. Honjo

  Proceedings of the National Academy of Sciences, 29 Nov. 2011, Peer-reviewed, Lead author

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• Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

  I.-m. Okazaki; K. Okawa; M. Kobayashi; K. Yoshikawa; S. Kawamoto; H. Nagaoka; R. Shinkura; Y. Kitawaki; H. Taniguchi; T. Natsume; S.-I. Iemura; T. Honjo

  Proceedings of the National Academy of Sciences, 10 May 2011, Peer-reviewed

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• Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity.

  Nagaoka Hitoshi; Tran Thinh Huy; Kobayashi Maki; Aida Masatoshi; Honjo Tasuku

  International immunology, Apr. 2010, Peer-reviewed

  
• AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

  Maki Kobayashi; Masatoshi Aida; Hitoshi Nagaoka; Nasim A. Begum; Yoko Kitawaki; Mikiyo Nakata; Andre Stanlie; Tomomitsu Doi; Lucia Kato; Il-mi Okazaki; Reiko Shinkura; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo

  Proceedings of the National Academy of Sciences, 29 Dec. 2009, Peer-reviewed, Lead author

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• GATA2-dependent and region-specific regulation ofGata2transcription in the mouse midbrain

  Daisuke Nozawa; Norio Suzuki; Maki Kobayashi-Osaki; Xiaoqing Pan; James Douglas Engel; Masayuki Yamamoto

  Genes to Cells, May 2009

  
• GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene

  Maki Kobayashi-Osaki; Osamu Ohneda; Norio Suzuki; Naoko Minegishi; Tomomasa Yokomizo; Satoru Takahashi; Kim-Chew Lim; James Douglas Engel; Masayuki Yamamoto

  Molecular and Cellular Biology, 15 Aug. 2005

  
• SH2D1A mutations in Japanese males with severe Epstein-Barr virus–associated illnesses

  Ryo Sumazaki; Hirokazu Kanegane; Maki Osaki; Takashi Fukushima; Masahiro Tsuchida; Hiroyoshi Matsukura; Kentaro Shinozaki; Hiroshi Kimura; Akira Matsui; Toshio Miyawaki

  Blood, 15 Aug. 2001

  
• Persistence and clinical outcome of hepatitis G virus infection in pediatric bone marrow transplant recipients and children treated for hematological malignancy

  Maki Yamada-Osaki; Ryo Sumazaki; Masahiro Tsuchida; Kazutoshi Koike; Takashi Fukushima; Akira Matsui

  Blood, Jan. 1999, Peer-reviewed, Lead author

  
• Transfusion transmitted virus

  Maki Yamada-Osaki; Ryo Sumazaki; Emiko Noguchi; Masanao Shibasaki; Akira Matsui

  The Lancet, Oct. 1998

  
• Transfusion transmitted virus

  Ryo Sumazaki; Maki Yamada-Osaki; Yasuhiro Kajiwara; Akira Shirahata; Akira Matsui

  The Lancet, Oct. 1998

  
• Natural course of HGV infection in haemophiliacs

  Maki Yamada-Osaki; Ryo Sumazaki; Yasuhiro Kajiwara; Takayuki Miyakawa; Akira Shirahata; Akira Matsui

  British Journal of Haematology, Jul. 1998

  
• Resolution of protein-losing hypertrophic gastropathy by eradication of Helicobacter pylori.

  Maki Yamada-Osaki; Ryo Sumazaki; Hideyo Kinugasa; Tahmeed Ahmed; Takako Matsubara; Tetsuo Hori; Akira Nakahara; Hitoshi Takita

  European Journal of Pediatrics, Feb. 1997, Lead author

  
• Pseudocoarctation of the aorta coexistent with coarctation

  M. Yamada; H. Horigome; S. Ishii

  European Journal of Pediatrics, Nov. 1996

  

Misc.

• Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity

  NAGAOKA Hitoshi; TRAN Thinh Huy; KOBAYASHI Maki; AIDA Masatoshi; HONJO Tasuku

  Int Immunol., 01 Apr. 2010