Basic Information

Email Address

• Email Address

  deguchi.sayaka.3ckyoto-u.ac.jp

Academic Degree

• 24 Mar. 2021

  大阪大学修士（薬科学）
• 25 Mar. 2024

  京都大学博士（医科学）

Academic Resume (Undergraduate School/Majors)

• 大阪大学, 薬学部薬科学科, 卒業

ID,URL

• ORCID ID

  0009-0007-2392-554X

• J-Global ID

  202201000704592621

Research

Papers

• Organoids and microphysiological systems for pharmaceutical research of viral respiratory infections.

  Sayaka Deguchi; Fuki Yokoi; Kazuo Takayama

  Drug metabolism and pharmacokinetics, 15 Nov. 2024

  
• Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs.

  Junya Michibata; Yoshimasa Kawaguchi; Hisaaki Hirose; Akiko Eguchi; Sayaka Deguchi; Kazuo Takayama; Wei Xu; Takuro Niidome; Yoshihiro Sasaki; Kazunari Akiyoshi; Shiroh Futaki

  Bioconjugate chemistry, 05 Nov. 2024

  
• Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells.

  Fuki Yokoi; Sayaka Deguchi; Yukio Watanabe; Kazuo Takayama

  iScience, 18 Oct. 2024, Lead author

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• Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.

  Ryosuke Negoro; Ayu Ouchi; Sayaka Deguchi; Kazuo Takayama; Takuya Fujita

  Biological & pharmaceutical bulletin, 2024

  
• Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant.

  Shuhei Tsujino; Sayaka Deguchi; Tomo Nomai; Miguel Padilla-Blanco; Arnon Plianchaisuk; Lei Wang; Mst Monira Begum; Keiya Uriu; Keita Mizuma; Naganori Nao; Isshu Kojima; Tomoya Tsubo; Jingshu Li; Yasufumi Matsumura; Miki Nagao; Yoshitaka Oda; Masumi Tsuda; Yuki Anraku; Shunsuke Kita; Hisano Yajima; Kaori Sasaki-Tabata; Ziyi Guo; Alfredo A Hinay Jr; Kumiko Yoshimatsu; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Hesham Nasser; Michael Jonathan; Olivia Putri; Yoonjin Kim; Luo Chen; Rigel Suzuki; Tomokazu Tamura; Katsumi Maenaka; Takashi Irie; Keita Matsuno; Shinya Tanaka; Jumpei Ito; Terumasa Ikeda; Kazuo Takayama; Jiri Zahradnik; Takao Hashiguchi; Takasuke Fukuhara; Kei Sato

  Microbiology and immunology, 04 Jul. 2024, Lead author

  
• Construction of multilayered small intestine-like tissue by reproducing interstitial flow.

  Sayaka Deguchi; Kaori Kosugi; Naoki Takeishi; Yukio Watanabe; Shiho Morimoto; Ryosuke Negoro; Fuki Yokoi; Hiroki Futatsusako; May Nakajima-Koyama; Mio Iwasaki; Takuya Yamamoto; Yoshiya Kawaguchi; Yu-Suke Torisawa; Kazuo Takayama

  Cell stem cell, 03 Jul. 2024, Lead author, Corresponding author

  
• Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236.

  Shigeru Fujita; Arnon Plianchaisuk; Sayaka Deguchi; Hayato Ito; Naganori Nao; Lei Wang; Hesham Nasser; Tomokazu Tamura; Izumi Kimura; Yukie Kashima; Rigel Suzuki; Saori Suzuki; Izumi Kida; Masumi Tsuda; Yoshitaka Oda; Rina Hashimoto; Yukio Watanabe; Keiya Uriu; Daichi Yamasoba; Ziyi Guo; Alfredo A Hinay Jr; Yusuke Kosugi; Luo Chen; Lin Pan; Yu Kaku; Hin Chu; Flora Donati; Sarah Temmam; Marc Eloit; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yutaka Suzuki; Jumpei Ito; Terumasa Ikeda; Shinya Tanaka; Keita Matsuno; Takasuke Fukuhara; Kazuo Takayama; Kei Sato

  EBioMedicine, Jun. 2024, Lead author

  
• Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs.

  Mengyang Wang; Yuko Sasaki; Rena Sakagami; Tomotaka Minamikawa; Masahiro Tsuda; Ryohei Ueno; Sayaka Deguchi; Ryosuke Negoro; Kanako So; Yuriko Higuchi; Ryuji Yokokawa; Kazuo Takayama; Fumiyoshi Yamashita

  ACS biomaterials science & engineering, 08 Jul. 2024

  
• A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

  Kenjiro Hanaoka; Takayuki Ikeno; Shimpei Iwaki; Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Fumiya Tao; Nobuhiko Kojima; Hisashi Ohno; Eita Sasaki; Toru Komatsu; Tasuku Ueno; Kazuya Maeda; Hiroyuki Kusuhara; Yasuteru Urano

  Science advances, 16 Feb. 2024

  
• Virological characteristics of the SARS-CoV-2 BA.2.86 variant.

  Tomokazu Tamura; Keita Mizuma; Hesham Nasser; Sayaka Deguchi; Miguel Padilla-Blanco; Yoshitaka Oda; Keiya Uriu; Jarel E M Tolentino; Shuhei Tsujino; Rigel Suzuki; Isshu Kojima; Naganori Nao; Ryo Shimizu; Lei Wang; Masumi Tsuda; Michael Jonathan; Yusuke Kosugi; Ziyi Guo; Alfredo A Hinay Jr; Olivia Putri; Yoonjin Kim; Yuri L Tanaka; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Akatsuki Saito; Jumpei Ito; Takashi Irie; Shinya Tanaka; Jiri Zahradnik; Terumasa Ikeda; Kazuo Takayama; Keita Matsuno; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 14 Feb. 2024, Lead author

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• Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.

  Tomokazu Tamura; Takashi Irie; Sayaka Deguchi; Hisano Yajima; Masumi Tsuda; Hesham Nasser; Keita Mizuma; Arnon Plianchaisuk; Saori Suzuki; Keiya Uriu; Mst Monira Begum; Ryo Shimizu; Michael Jonathan; Rigel Suzuki; Takashi Kondo; Hayato Ito; Akifumi Kamiyama; Kumiko Yoshimatsu; Maya Shofa; Rina Hashimoto; Yuki Anraku; Kanako Terakado Kimura; Shunsuke Kita; Jiei Sasaki; Kaori Sasaki-Tabata; Katsumi Maenaka; Naganori Nao; Lei Wang; Yoshitaka Oda; Terumasa Ikeda; Akatsuki Saito; Keita Matsuno; Jumpei Ito; Shinya Tanaka; Kei Sato; Takao Hashiguchi; Kazuo Takayama; Takasuke Fukuhara

  Nature communications, 08 Feb. 2024, Lead author

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• SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids.

  Kazuya Fujimoto; Yoshikazu Kameda; Yuta Nagano; Sayaka Deguchi; Takuya Yamamoto; Rafal P Krol; Peter Gee; Yasufumi Matsumura; Toru Okamoto; Miki Nagao; Kazuo Takayama; Ryuji Yokokawa

  Lab on a chip, 22 Jan. 2024

  
• Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

  Eri Kawakami; Norikazu Saiki; Yosuke Yoneyama; Chiharu Moriya; Mari Maezawa; Shuntaro Kawamura; Akiko Kinebuchi; Tamaki Kono; Masaaki Funata; Ayaka Sakoda; Shigeru Kondo; Takeshi Ebihara; Hisatake Matsumoto; Yuki Togami; Hiroshi Ogura; Fuminori Sugihara; Daisuke Okuzaki; Takashi Kojima; Sayaka Deguchi; Sebastien Vallee; Susan McQuade; Rizwana Islam; Madhusudan Natarajan; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yunheng Wu; Kensaku Mori; Takayuki Hishiki; Tomohiko Takasaki; Yasushi Itoh; Kazuo Takayama; Yasunori Nio; Takanori Takebe

  Cell stem cell, 05 Oct. 2023

  
• Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.

  Izumi Kimura; Daichi Yamasoba; Hesham Nasser; Hayato Ito; Jiri Zahradnik; Jiaqi Wu; Shigeru Fujita; Keiya Uriu; Jiei Sasaki; Tomokazu Tamura; Rigel Suzuki; Sayaka Deguchi; Arnon Plianchaisuk; Kumiko Yoshimatsu; Yasuhiro Kazuma; Shuya Mitoma; Gideon Schreiber; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Akifumi Takaori-Kondo; Jumpei Ito; Kotaro Shirakawa; Kazuo Takayama; Takashi Irie; Takao Hashiguchi; So Nakagawa; Takasuke Fukuhara; Akatsuki Saito; Terumasa Ikeda; Kei Sato

  Journal of virology, 05 Oct. 2023

  
• Organ-on-a-chip models for elucidating the cellular biology of infectious diseases.

  Fuki Yokoi; Sayaka Deguchi; Kazuo Takayama

  Biochimica et biophysica acta. Molecular cell research, 26 May 2023, Lead author

  
• Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.

  Tomokazu Tamura; Jumpei Ito; Keiya Uriu; Jiri Zahradnik; Izumi Kida; Yuki Anraku; Hesham Nasser; Maya Shofa; Yoshitaka Oda; Spyros Lytras; Naganori Nao; Yukari Itakura; Sayaka Deguchi; Rigel Suzuki; Lei Wang; Mst Monira Begum; Shunsuke Kita; Hisano Yajima; Jiei Sasaki; Kaori Sasaki-Tabata; Ryo Shimizu; Masumi Tsuda; Yusuke Kosugi; Shigeru Fujita; Lin Pan; Daniel Sauter; Kumiko Yoshimatsu; Saori Suzuki; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Gideon Schreiber; Katsumi Maenaka; Takao Hashiguchi; Terumasa Ikeda; Takasuke Fukuhara; Akatsuki Saito; Shinya Tanaka; Keita Matsuno; Kazuo Takayama; Kei Sato

  Nature communications, 16 May 2023

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• Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.

  Jumpei Ito; Rigel Suzuki; Keiya Uriu; Yukari Itakura; Jiri Zahradnik; Kanako Terakado Kimura; Sayaka Deguchi; Lei Wang; Spyros Lytras; Tomokazu Tamura; Izumi Kida; Hesham Nasser; Maya Shofa; Mst Monira Begum; Masumi Tsuda; Yoshitaka Oda; Tateki Suzuki; Jiei Sasaki; Kaori Sasaki-Tabata; Shigeru Fujita; Kumiko Yoshimatsu; Hayato Ito; Naganori Nao; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Jin Kuramochi; Gideon Schreiber; Akatsuki Saito; Keita Matsuno; Kazuo Takayama; Takao Hashiguchi; Shinya Tanaka; Takasuke Fukuhara; Terumasa Ikeda; Kei Sato

  Nature communications, 11 May 2023, Lead author

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• Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips.

  Sayaka Deguchi; Kaori Kosugi; Rina Hashimoto; Ayaka Sakamoto; Masaki Yamamoto; Rafal P Krol; Peter Gee; Ryosuke Negoro; Takeshi Noda; Takuya Yamamoto; Yu-Suke Torisawa; Miki Nagao; Kazuo Takayama

  PNAS nexus, Mar. 2023, Lead author

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• State-of-the-art liver disease research using liver-on-a-chip.

  Sayaka Deguchi; Kazuo Takayama

  Inflammation and regeneration, 09 Dec. 2022, Lead author

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• Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.

  Akatsuki Saito; Tomokazu Tamura; Jiri Zahradnik; Sayaka Deguchi; Koshiro Tabata; Yuki Anraku; Izumi Kimura; Jumpei Ito; Daichi Yamasoba; Hesham Nasser; Mako Toyoda; Kayoko Nagata; Keiya Uriu; Yusuke Kosugi; Shigeru Fujita; Maya Shofa; Mst Monira Begum; Ryo Shimizu; Yoshitaka Oda; Rigel Suzuki; Hayato Ito; Naganori Nao; Lei Wang; Masumi Tsuda; Kumiko Yoshimatsu; Jin Kuramochi; Shunsuke Kita; Kaori Sasaki-Tabata; Hideo Fukuhara; Katsumi Maenaka; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Takamasa Ueno; Gideon Schreiber; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hirofumi Sawa; Takashi Irie; Takao Hashiguchi; Kazuo Takayama; Keita Matsuno; Shinya Tanaka; Terumasa Ikeda; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 09 Nov. 2022, Lead author

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• Application of perfluoropolyether elastomers in microfluidic drug metabolism assays.

  Mengyang Wang; Masahiro Tsuda; Sayaka Deguchi; Yuriko Higuchi; Kanako So; Yu-Suke Torisawa; Kazuo Takayama; Fumiyoshi Yamashita

  International journal of pharmaceutics, 05 Nov. 2022

  
• SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

  Rina Hashimoto; Junya Takahashi; Keisuke Shirakura; Risa Funatsu; Kaori Kosugi; Sayaka Deguchi; Masaki Yamamoto; Yugo Tsunoda; Maaya Morita; Kosuke Muraoka; Masato Tanaka; Tomoaki Kanbara; Shota Tanaka; Shigeyuki Tamiya; Nagisa Tokunoh; Atsushi Kawai; Masahito Ikawa; Chikako Ono; Keisuke Tachibana; Masuo Kondoh; Masanori Obana; Yoshiharu Matsuura; Akihiro Ohsumi; Takeshi Noda; Takuya Yamamoto; Yasuo Yoshioka; Yu-Suke Torisawa; Hiroshi Date; Yasushi Fujio; Miki Nagao; Kazuo Takayama; Yoshiaki Okada

  Science advances, 23 Sep. 2022

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• Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System.

  Ryosuke Negoro; Mitsuki Tasaka; Sayaka Deguchi; Kazuo Takayama; Takuya Fujita

  Cells, 18 May 2022

  
• Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells.

  Rina Hashimoto; Ayaka Sakamoto; Sayaka Deguchi; Renxing Yi; Emi Sano; Akitsu Hotta; Kazutoshi Takahashi; Shinya Yamanaka; Kazuo Takayama

  Molecular therapy. Nucleic acids, 03 Dec. 2021

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• SARS-CoV-2 research using human pluripotent stem cells and organoids.

  Sayaka Deguchi; Ángel Serrano-Aroca; Murtaza M Tambuwala; Bruce D Uhal; Adam M Brufsky; Kazuo Takayama

  Stem cells translational medicine, Nov. 2021, Lead author

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• Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.

  Emi Sano; Sayaka Deguchi; Naoki Matsuoka; Masahiro Tsuda; Mengyang Wang; Kaori Kosugi; Chihiro Mori; Keisuke Yagi; Aya Wada; Shinsuke Yamasaki; Tsuyoshi Kawai; Masahide Yodogawa; Hiroyuki Mizuguchi; Norihito Nakazawa; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS omega, 28 Sep. 2021, Lead author

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• Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.

  Sayaka Deguchi; Masahiro Tsuda; Kaori Kosugi; Ayaka Sakamoto; Natsumi Mimura; Ryosuke Negoro; Emi Sano; Takuro Nobe; Kazuya Maeda; Hiroyuki Kusuhara; Hiroyuki Mizuguchi; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS biomaterials science & engineering, 09 Aug. 2021, Lead author

  
• In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

  Sayaka Deguchi; Tomohiro Shintani; Kazuo Harada; Toru Okamoto; Akinori Takemura; Kazumasa Hirata; Kousei Ito; Kazuo Takayama; Hiroyuki Mizuguchi

  Hepatology communications, Aug. 2021, Lead author

  
• Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells.

  Emi Sano; Sayaka Deguchi; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama

  iScience, 21 May 2021

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• Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies.

  Kanae Kawai; Ryosuke Negoro; Moe Ichikawa; Tomoki Yamashita; Sayaka Deguchi; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  Molecular therapy. Methods & clinical development, 12 Jun. 2020

  
• Establishment of MDR1-knockout human induced pluripotent stem cell line.

  Ryosuke Negoro; Kanae Kawai; Moe Ichikawa; Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi

  Drug metabolism and pharmacokinetics, Jun. 2020

  
• Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

  Ayumi Kiso; Yukiko Toba; Susumu Tsutsumi; Sayaka Deguchi; Keisuke Igai; Saki Koshino; Yasuhito Tanaka; Kazuo Takayama; Hiroyuki Mizuguchi

  Hepatology communications, Feb. 2020

  
• Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine.

  Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi

  Biological & pharmaceutical bulletin, 2020, Lead author

  
• Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.

  Yukiko Toba; Sayaka Deguchi; Natsumi Mimura; Ayaka Sakamoto; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  PloS one, 2020

  
• Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.

  Sayaka Deguchi; Tomoki Yamashita; Keisuke Igai; Kazuo Harada; Yukiko Toba; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  Drug metabolism and disposition: the biological fate of chemicals, Jun. 2019, Lead author

  

Misc.

• Research on intestinal infections using organoid technology.

  出口清香; 横井歩希; 高山和雄

  月刊臨床免疫・アレルギー科, 2023

  
• State-of-the-art in respiratory disease research using respiratory organoids

  Deguchi Sayaka; Takayama Kazuo

  Folia Pharmacologica Japonica, 2023

  
• ヒトiPS細胞由来分化細胞の創薬応用 第2回 ヒトiPS細胞やオルガノイドを用いたSARS-CoV-2研究

  出口清香; 高山和雄

  和光純薬時報, 2021

  
• いま知りたい!!真の生理学性に挑むorgan-on-a-chip 2 隔膜型デバイスを用いた呼吸器チップの開発と応用

  出口清香; 高山和雄

  実験医学, 2021