Nakagawa, Masahiro(Graduate School of Medicine, Medicine) | Activity Database on Education and Research, Kyoto University

Nakagawa, Masahiro

Graduate School of Medicine, Medicine Associate Professor

Last Updated :2025/04/23

Basic Information

Faculty

Faculty of Medicine

Academic Degree

博士（医学）(東京大学)

Language of Instruction

English

ID,URL

ORCID ID
0000-0002-6420-2555
J-Global ID
201601019377586090
Researcher number
10431850

researchmap URL

https://researchmap.jp/nakagawa-mm

Last Updated :2025/04/23

Research

Research Topics, Overview of the research

Research Topics
Single cell analysis of hematological malignancies.
Overview of the research
Development of novel single cell analysis platform and clonal analysis of hematological malignancies.

Research Areas

Life sciences, Tumor biology

Papers

Der(1;7)(q10;p10)を有する骨髄異形成症候群や関連疾患の特徴
奥田瑠璃花; 越智陽太郎; 佐伯龍之介; 中川正宏; 後藤明彦; 熱田由子; 白石友一; 三谷絹子; 千葉滋; 高折晃史; 宮野悟; 牧島秀樹; 南谷泰仁; 小川誠司
日本血液学会学術集会, Oct. 2024

単一細胞マルチオミクス解析によるクローン性造血の病態解明
中川正宏; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 越智陽太郎; 本村公則; 昆彩奈; 岡崎幸治; 竹田淳恵; 戚星星; 依田成玄; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本血液学会学術集会, Oct. 2024

クローン性造血の単一細胞変異と単一細胞エピゲノムの同時解析
本村公則; 越智陽太郎; 中川正宏; 南谷泰仁; 垣内伸之; 黒田隆; 中川智恵; 趙蘭英; 宮野悟; 松田秀一; 小川誠司
日本血液学会学術集会, Oct. 2024

骨髄性腫瘍988例の全ゲノム解析
岡崎幸治; 吉田健一; 高森弘之; 福島英人; 横山和明; 三村海渡; 本村公則; 奥田瑠璃花; 佐伯龍之介; 小笠原辰樹; 中川正宏; 越智陽太郎; 片山琴絵; 井元清哉; 小川誠司; 南谷泰仁
日本血液学会学術集会, Oct. 2024

クロマチンアクセシビリティ解析による急性骨髄性白血病の新規分子サブグループの同定
越智陽太郎; Markus Liew; 南谷泰仁; 笠原千嗣; 平本展大; 兼村信宏; 瀬崎伸夫; 櫻田麻希; 岩崎惇; 諫田淳也; 上田恭典; 吉原哲; Albin Osterroos; 本村公則; 中川正宏; 佐伯龍之介; 福島英人; 岡崎幸治; 依田成玄; 奥田瑠璃花; Lanying Zhao; 白石友一; 石川隆之; 宮野悟; 鈴木洋; 高折晃史; Soren Lehmann; 小川誠司
日本血液学会学術集会, Oct. 2024

骨髄性腫瘍988例の全ゲノム解析(Whole-genome sequencing of 988 myeloid neoplasms)
岡崎幸治; 高森弘之; 福島英人; 横山和明; 三村海渡; 本村公則; 奥田瑠璃花; 佐伯龍之介; 小笠原辰樹; 中川正宏; 吉田健一; 越智陽太郎; 片山琴絵; 井元清哉; 小川誠司; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2024

Der(1;7)(q10;p10)を有する骨髄異形成症候群や関連疾患(Myeloid neoplasms with der(1;7)(q10;p10))
奥田瑠璃花; 越智陽太郎; 佐伯龍之介; 中川正宏; 後藤明彦; 熱田由子; 白石友一; 三谷絹子; 千葉滋; 高折晃史; 宮野悟; 牧島秀樹; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2024

クローン性造血の単一細胞変異と単一細胞エピゲノムの同時解析(Simultaneous single cell genetic and epigenetic analysis of clonal hematopoiesis)
本村公則; 越智陽太郎; 中川正宏; 南谷泰仁; 垣内伸之; 黒田隆; 中川智恵; 趙蘭英; 宮野悟; 松田秀一; 小川誠司; 小川誠司
日本癌学会総会記事, Sep. 2024

単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
中川正宏; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 越智陽太郎; 本村公則; 昆彩奈; 岡崎幸治; 竹田淳恵; 威星星; 依田成玄; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司
日本癌学会総会記事, Sep. 2024

Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)
Rurika Okuda; Yotaro Ochi; Ryunosuke Saiki; Toshiyuki Yamanaka; Chikashi Terao; Tetsuichi Yoshizato; Masahiro M. Nakagawa; Lanying Zhao; Kazuma Ohyashiki; Nobuhiro Hiramoto; Masashi Sanada; Hiroshi Handa; Senji Kasahara; Yasushi Miyazaki; Nobuo Sezaki; Lee-Yung Shih; Wolfgang Kern; Nobuhiro Kanemura; Toshiyuki Kitano; Shinsaku Imashuku; Mitsumasa Watanabe; Maria Creignou; Kazuhisa Chonabayashi; Kensuke Usuki; Takayuki Ishikawa; Akihiko Gotoh; Yoshiko Atsuta; Yuichi Shiraishi; Kinuko Mitani; Shigeru Chiba; Akifumi Takaori-Kondo; Satoru Miyano; Yoichiro Kamatani; Torsten Haferlach; Eva Hellström-Lindberg; Koichi Matsuda; Yoshinori Yoshida; Hideki Makishima; Yasuhito Nannya; Seishi Ogawa
Leukemia, 23 Dec. 2024

Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells
Pedro Luis Moura; Yasuhito Nannya; Affaf Aliouat; Isabel Juliana Hofman; Teresa Mortera-Blanco; Tetsuichi Yoshizato; Ryunosuke Saiki; Masahiro M. Nakagawa; Maria Creignou; Ann-Charlotte Björklund; Gunilla Walldin; Indira Barbosa; Monika Jansson; Francesca Grasso; Edda M. Elvarsdottir; Petter S. Woll; Sten Eirik W. Jacobsen; Seishi Ogawa; Eva Hellström-Lindberg
Blood Neoplasia, Jun. 2024
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Evolutionary histories of breast cancer and related clones.
Tomomi Nishimura; Nobuyuki Kakiuchi; Kenichi Yoshida; Takaki Sakurai; Tatsuki R Kataoka; Eiji Kondoh; Yoshitsugu Chigusa; Masahiko Kawai; Morio Sawada; Takuya Inoue; Yasuhide Takeuchi; Hirona Maeda; Satoko Baba; Yusuke Shiozawa; Ryunosuke Saiki; Masahiro M Nakagawa; Yasuhito Nannya; Yotaro Ochi; Tomonori Hirano; Tomoe Nakagawa; Yukiko Inagaki-Kawata; Kosuke Aoki; Masahiro Hirata; Kosaku Nanki; Mami Matano; Megumu Saito; Eiji Suzuki; Masahiro Takada; Masahiro Kawashima; Kosuke Kawaguchi; Kenichi Chiba; Yuichi Shiraishi; Junko Takita; Satoru Miyano; Masaki Mandai; Toshiro Sato; Kengo Takeuchi; Hironori Haga; Masakazu Toi; Seishi Ogawa
Nature, Aug. 2023
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AMLにおける分子病態と標的薬単一細胞解析によって示唆されたAMLにおけるRAS経路変異クローンの役割(Single-cell DNA/RNA analysis revealed roles of RAS pathway mutated clones in AML)
稲垣良作; 中川正宏; 南谷泰仁; 戚星星; 趙蘭英; 竹田淳恵; 依田成玄; 昆彩奈; 黒田隆; 鶴見寿; 牧島秀樹; 小川誠司
日本血液学会学術集会, Sep. 2021

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.
Mayuki Omatsu; Yuki Nakanishi; Kosuke Iwane; Naoki Aoyama; Angeles Duran; Yu Muta; Anxo Martinez-Ordoñez; Qixiu Han; Nobukazu Agatsuma; Kenta Mizukoshi; Munenori Kawai; Go Yamakawa; Mio Namikawa; Kensuke Hamada; Yuichi Fukunaga; Takahiro Utsumi; Makoto Sono; Tomonori Masuda; Akitaka Hata; Osamu Araki; Munemasa Nagao; Takaaki Yoshikawa; Satoshi Ogawa; Yukiko Hiramatsu; Motoyuki Tsuda; Takahisa Maruno; Toshiaki Kogame; Hiroaki Kasashima; Nobuyuki Kakiuchi; Masahiro M Nakagawa; Kenji Kawada; Masakazu Yashiro; Kiyoshi Maeda; Yasuyuki Saito; Takashi Matozaki; Akihisa Fukuda; Kenji Kabashima; Kazutaka Obama; Seishi Ogawa; Nader Sheibani; Maria T Diaz-Meco; Jorge Moscat; Hiroshi Seno
Nature communications, 25 Sep. 2023
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単一細胞マルチオミクス解析によるクローン造血の病態解明
中川正宏; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 越智陽太郎; 本村公則; 竹田淳恵; 戚星星; 岡崎幸治; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本血液学会学術集会, Oct. 2023

クロマチンアクセシビリティ解析による急性骨髄性白血病のエピジェネティクス不均一性の解明
越智陽太郎; 南谷泰仁; Liew-Littorin Markus; 笠原千嗣; 平本展大; 兼村信宏; 瀬崎伸夫; 櫻田麻希; 岩崎惇; 諫田淳也; 上田恭典; 吉原哲; Osterroos Albin; 本村公則; 中川正宏; 佐伯龍之介; 依田成玄; 奥田瑠璃花; 白石友一; 石川隆之; 宮野悟; 高折晃史; Lehmann Soren; 小川誠司
日本血液学会学術集会, Oct. 2023

がんのRNA異常の核心に迫る/The Nexus of RNA Dysregulation in Cancer 骨髄性腫瘍を標的とした新規スプライシング阻害剤CTX-712の開発(CTX-712, a novel splicing inhibitor targeting myeloid neoplasms)
依田成玄; 森下大輔; 越智陽太郎; 水谷明生; 森拓人; 竹田淳恵; 戸崎浩和; 佐藤義彦; 牧島秀樹; 中川正宏; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2023

骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Pathogenetic role of germline and somatic DDX41 mutations in the pathogenesis of myeloid malignancies)
昆彩奈; 中川正宏; 片岡圭亮; 森拓人; 垣内伸之; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2023

単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
中川正宏; 南谷泰仁; 超蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本癌学会総会記事, Sep. 2023

骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies)
昆彩奈; 中川正宏; 片岡圭亮; 垣内伸之; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2022

単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
中川正宏; 稲垣良作; 南谷泰仁; 佐伯龍之介; 越智陽太郎; 竹田淳恵; 趙蘭英; 威星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本癌学会総会記事, Sep. 2022

骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders)
森拓人; 越智陽太郎; 昆彩奈; 吉里哲一; 古関明彦; 依田成玄; 中川正宏; 竹田淳恵; 永田安伸; 吉田健一; 眞田昌; 牧島秀樹; 高折晃史; 熱田由子; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2022

Post-azacitidine clone size predicts outcome of patients with myelodysplastic syndromes and related myeloid neoplasms.
Yasuhito Nannya; Magnus Tobiasson; Shinya Sato; Elsa Bernard; Shigeki Ohtake; June Takeda; Maria Creignou; Lanying Zhao; Manabu Kusakabe; Yuhei Shibata; Nobuhiko Nakamura; Mizuki Watanabe; Nobuhiro Hiramoto; Yusuke Shiozawa; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Yoshida; Nobuyuki Kakiuchi; Hideki Makishima; Masahiro Marshall Nakagawa; Kensuke Usuki; Mitsumasa Watanabe; Kazunori Imada; Hiroshi Handa; Masataka Taguchi; Toru Kiguchi; Kazuma Ohyashiki; Takayuki Ishikawa; Akifumi Takaori-Kondo; Hisashi Tsurumi; Senji Kasahara; Shigeru Chiba; Tomoki Naoe; Satoru Miyano; Elli Papaemmanuil; Yasushi Miyazaki; Eva Hellström Lindberg; Seishi Ogawa
Blood advances, 29 Mar. 2023, Peer-reviewed
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Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.
Hideki Makishima; Ryunosuke Saiki; Yasuhito Nannya; Sophia Korotev; Carmelo Gurnari; June Takeda; Yukihide Momozawa; Steve Best; Pramila Krishnamurthy; Tetsuichi Yoshizato; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Yasunobu Nagata; Nobuyuki Kakiuchi; Makoto Onizuka; Kenichi Chiba; Hiroko Tanaka; Ayana Kon; Yotaro Ochi; Masahiro M Nakagawa; Rurika Okuda; Takuto Mori; Akinori Yoda; Hidehiro Itonaga; Yasushi Miyazaki; Masashi Sanada; Takayuki Ishikawa; Shigeru Chiba; Hisashi Tsurumi; Senji Kasahara; Carsten Müller-Tidow; Akifumi Takaori-Kondo; Kazuma Ohyashiki; Toru Kiguchi; Fumihiko Matsuda; Joop H Jansen; Chantana Polprasert; Piers Blombery; Yoichiro Kamatani; Satoru Miyano; Luca Malcovati; Torsten Haferlach; Michiaki Kubo; Mario Cazzola; Austin G Kulasekararaj; Lucy A Godley; Jaroslaw P Maciejewski; Seishi Ogawa
Blood, 02 Feb. 2023

MDS、AMLに対するアザシチジン治療後のクローンサイズは長期予後を予測する(Post-azacitidine clone size predicts long-term clinical outcome of patients with MDS and AML)
南谷泰仁; Magnus Tobiasson; 佐藤信也; Elsa Bernard; 大竹茂樹; 竹田淳恵; 趙蘭英; 日下部学; 柴田悠平; 中村信彦; 渡邊瑞希; 平本展大; 塩澤裕介; 白石友一; 牧島秀樹; 中川正宏; 田口正剛; 木口亨; 大屋敷一馬; 石川隆之; 高折晃史; 鶴見寿; 笠原千嗣; 千葉滋; 直江知樹; 宮野悟; Elli Papaemanuil; 宮崎泰司; Eva Lindberg; 小川誠司
日本血液学会学術集会, Sep. 2021

The Genetic Landscape Of FPD/AML Revealed CDC25C Mutation As a Driver That Promotes Malignant Transformation
Akihide Yoshimi; Takashi Toya; Masahiro Nakagawa; Masahito Kawazu; Yasuhito Nannya; Motoshi Ichikawa; Shunya Arai; Hironori Harada; Kensuke Usuki; Yasuhide Hayashi; Etsuro Ito; Keita Kirito; Hideaki Nakajima; Hiroyuki Mano; Mineo Kurokawa
Blood, 15 Nov. 2013

NF-κB/TNF-α Positive Feedback Loop with Active Proteasome Machinery Supports Myeloid Leukemia Initiating Cell Capacity
Yuki Kagoya; Akihide Yoshimi; Shunya Arai; Keisuke Kataoka; Masahiro Nakagawa; Keiki Kumano; Mineo Kurokawa
Blood, 16 Nov. 2012

Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling.
Akitada Yogo; Toshihiko Masui; Shigeo Takaishi; Kenji Masuo; Ru Chen; Yosuke Kasai; Kazuyuki Nagai; Takayuki Anazawa; Sadanori Watanabe; Satoko Sakamoto; Akira Watanabe; Ryosaku Inagaki; Masahiro M Nakagawa; Seishi Ogawa; Hiroshi Seno; Shinji Uemoto; Etsuro Hatano
Cancer science, 28 Nov. 2022

正常乳管上皮細胞から乳癌に至るクローン進化
西村友美; 垣内伸之; 吉田健一; 竹内康英; 前田紘奈; 南谷泰仁; 塩澤裕介; 中川正宏; 越智陽太郎; 佐伯龍之介; 片岡竜貴; 桜井孝規; 馬場郷子; 白石友一; 千葉健一; 竹内賢吾; 羽賀博典; 宮野悟; 戸井雅和; 小川誠司
日本乳癌学会総会プログラム抄録集, Jun. 2022

骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies)
昆彩奈; 中川正宏; 片岡圭亮; 垣内伸之; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2022

単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
中川正宏; 稲垣良作; 南谷泰仁; 佐伯龍之介; 越智陽太郎; 竹田淳恵; 趙蘭英; 威星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本癌学会総会記事, Sep. 2022

骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders)
森拓人; 越智陽太郎; 昆彩奈; 吉里哲一; 古関明彦; 依田成玄; 中川正宏; 竹田淳恵; 永田安伸; 吉田健一; 眞田昌; 牧島秀樹; 高折晃史; 熱田由子; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2022

正常乳管上皮細胞から乳癌に至るクローン進化
西村友美; 垣内伸之; 吉田健一; 竹内康英; 前田紘奈; 南谷泰仁; 塩澤裕介; 中川正宏; 越智陽太郎; 佐伯龍之介; 片岡竜貴; 桜井孝規; 馬場郷子; 白石友一; 千葉健一; 竹内賢吾; 羽賀博典; 宮野悟; 戸井雅和; 小川誠司
日本乳癌学会総会プログラム抄録集, Jun. 2022

Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia.
June Takeda; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
Blood cancer discovery, 15 Jul. 2022
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Molecular classification and diagnostics of upper urinary tract urothelial carcinoma.
Yoichi Fujii; Yusuke Sato; Hiromichi Suzuki; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Andrew T Lenis; Shigekatsu Maekawa; Akira Yokoyama; Yasuhide Takeuchi; Yoshikage Inoue; Yotaro Ochi; Yusuke Shiozawa; Kosuke Aoki; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yasuhito Nannya; Hideki Makishima; Jimpei Miyakawa; Taketo Kawai; Teppei Morikawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Genta Nagae; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Tohru Nakagawa; Masashi Fukayama; Tetsuo Ushiku; Hiroyuki Aburatani; Satoru Miyano; Jonathan A Coleman; Yukio Homma; David B Solit; Haruki Kume; Seishi Ogawa
Cancer cell, 14 Jun. 2021
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一細胞解像度のがん生物学変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 吉里哲一; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本癌学会総会記事, Sep. 2021

クローン性造血と造血器腫瘍、心血管性疾患、固形癌の関係性クローン性造血における遺伝子変異とコピー数異常の統合解析
佐伯龍之介; 桃沢幸秀; 南谷泰仁; 中川正宏; 越智陽太郎; 吉里哲一; 白石友一; 田中洋子; 新井田厚司; 井元清哉; 松田浩一; 村上善則; 松田秀一; 宮野悟; 牧島秀樹; 小川誠司
日本癌学会総会記事, Sep. 2021

骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明
昆彩奈; 中川正宏; 片岡圭亮; 稲垣良作; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会総会記事, Sep. 2021

赤白血病におけるゲノム解析と治療標的の検討
竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; 越智陽太郎; 中川正宏; 佐伯龍之介; 白石友一; 永田安伸; 高折晃史; 千葉滋; 片岡圭亮; 宮野悟; 牧島秀樹; 小川誠司
日本癌学会総会記事, Sep. 2021

Distinct pathogenesis of clonal hematopoiesis revealed by single-cell sequencing(和訳中)
中川正宏; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 吉里哲一; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本血液学会学術集会, Sep. 2021

The molecular pathogenesis of DDX41-mutated myeloid neoplasms(和訳中)
昆彩奈; 中川正宏; 片岡圭亮; 稲垣良作; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本血液学会学術集会, Sep. 2021

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.
Ryunosuke Saiki; Yukihide Momozawa; Yasuhito Nannya; Masahiro M Nakagawa; Yotaro Ochi; Tetsuichi Yoshizato; Chikashi Terao; Yutaka Kuroda; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Atsushi Niida; Seiya Imoto; Koichi Matsuda; Takayuki Morisaki; Yoshinori Murakami; Yoichiro Kamatani; Shuichi Matsuda; Michiaki Kubo; Satoru Miyano; Hideki Makishima; Seishi Ogawa
Nature medicine, 08 Jul. 2021
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Genomic analysis of multiple myeloma using targeted capture sequencing in the Japanese cohort
Takashi Kanamori; Masashi Sanada; Masaki Ri; Hiroo Ueno; Dai Nishijima; Takahiko Yasuda; Takuto Tachita; Tomoko Narita; Shigeru Kusumoto; Atsushi Inagaki; Rei Ishihara; Yuki Murakami; Nobuhiko Kobayashi; Yusuke Shiozawa; Kenichi Yoshida; Masahiro M. Nakagawa; Yasuhito Nannya; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Keizo Horibe; Hiroshi H; a; Seishi Ogawa; Shinsuke Iida
British Journal of Haematology, Dec. 2020

Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia
Hiroo Ueno; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Yuka Iijima-Yamashita; Nobutaka Kiyokawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Tomoya Isobe; Masafumi Seki; Shunsuke Kimura; Hideki Makishima; Masahiro M. Nakagawa; Nobuyuki Kakiuchi; Keisuke Kataoka; Tetsuichi Yoshizato; Dai Nishijima; Takao Deguchi; Kentaro Ohki; Atsushi Sato; Hiroyuki Takahashi; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Takeshi Inukai; Junko Takita; Toshihiko Imamura; Satoru Miyano; Atsushi Manabe; Keizo Horibe; Seishi Ogawa; Masashi Sanada
Blood Advances, 27 Oct. 2020

急性赤白血病におけるJAK阻害剤の検討
竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; 中川正宏; 越智陽太郎; 昆彩奈; 吉里哲一; 塩澤裕介; 白石友一; 千葉健一; 田中洋子; 真田昌; 宮野悟; 牧島秀樹; 小川誠司
日本癌学会総会記事, Oct. 2020

骨髄異形成症候群における新規DDX41胚細胞変異・体細胞変異の機能解析
昆彩奈; 中川正宏; 稲垣良作; 片岡圭亮; 越智陽太郎; 牧島秀樹; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会総会記事, Oct. 2020

がんの一細胞生物学骨髄系腫瘍の早期クローン進展の解析
中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本癌学会総会記事, Oct. 2020

急性赤白血病におけるJAK阻害剤の検討
竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; 中川正宏; 越智陽太郎; 昆彩奈; 吉里哲一; 塩澤裕介; 白石友一; 千葉健一; 田中洋子; 真田昌; 宮野悟; 牧島秀樹; 小川誠司
日本癌学会総会記事, Oct. 2020

骨髄異形成症候群における新規DDX41胚細胞変異・体細胞変異の機能解析
昆彩奈; 中川正宏; 稲垣良作; 片岡圭亮; 越智陽太郎; 牧島秀樹; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会総会記事, Oct. 2020

がんの一細胞生物学骨髄系腫瘍の早期クローン進展の解析
中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司
日本癌学会総会記事, Oct. 2020

Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.
Yotaro Ochi; Ayana Kon; Toyonori Sakata; Masahiro M Nakagawa; Naotaka Nakazawa; Masanori Kakuta; Keisuke Kataoka; Haruhiko Koseki; Manabu Nakayama; Daisuke Morishita; Tatsuaki Tsuruyama; Ryunosuke Saiki; Akinori Yoda; Rurika Okuda; Tetsuichi Yoshizato; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Shinichi Kotani; Yasunori Kogure; Nobuyuki Kakiuchi; Tomomi Nishimura; Hideki Makishima; Luca Malcovati; Akihiko Yokoyama; Kengo Takeuchi; Eiji Sugihara; Taka-Aki Sato; Masashi Sanada; Akifumi Takaori-Kondo; Mario Cazzola; Mineko Kengaku; Satoru Miyano; Katsuhiko Shirahige; Hiroshi I Suzuki; Seishi Ogawa
Cancer discovery, Jun. 2020, Peer-reviewed

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis
Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M. Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
Nature, 09 Jan. 2020, Peer-reviewed
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A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals
Masahiro Marshall Nakagawa; Chozha Vendan Rathinam
Scientific Reports, Dec. 2019, Peer-reviewed

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.
Yosaku Watatani; Yasuharu Sato; Hiroaki Miyoshi; Kana Sakamoto; Kenji Nishida; Yuka Gion; Yasunobu Nagata; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Lanying Zhao; Yotaro Ochi; Yasuhide Takeuchi; June Takeda; Hiroo Ueno; Yasunori Kogure; Yusuke Shiozawa; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Masahiro M Nakagawa; Yasuhito Nanya; Kenichi Yoshida; Hideki Makishima; Masashi Sanada; Mamiko Sakata-Yanagimoto; Shigeru Chiba; Ryota Matsuoka; Masayuki Noguchi; Nobuhiro Hiramoto; Takayuki Ishikawa; Junichi Kitagawa; Nobuhiko Nakamura; Hisashi Tsurumi; Tatsuhiko Miyazaki; Yusuke Kito; Satoru Miyano; Kazuya Shimoda; Kengo Takeuchi; Koichi Ohshima; Tadashi Yoshino; Seishi Ogawa; Keisuke Kataoka
Leukemia, Dec. 2019, Peer-reviewed

Molecular pathogenesis of disease progression in MLL-rearranged AML.
Shinichi Kotani; Akinori Yoda; Ayana Kon; Keisuke Kataoka; Yotaro Ochi; Yusuke Shiozawa; Cassandra Hirsch; June Takeda; Hiroo Ueno; Tetsuichi Yoshizato; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Nobuyuki Kakiuchi; Takuji Yamauchi; Kosuke Aoki; Yuichi Shiraishi; Satoru Miyano; Takahiro Maeda; Jaroslaw P Maciejewski; Akifumi Takaori-Kondo; Seishi Ogawa; Hideki Makishima
Leukemia, Mar. 2019, Peer-reviewed

Age-related remodelling of oesophageal epithelia by mutated cancer drivers.
Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Ki Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Yoshitaka Nishikawa; Yusuke Amanuma; Shinya Ohashi; Ikuo Aoyama; Takahiro Horimatsu; Shin'ichi Miyamoto; Shigeru Tsunoda; Yoshiharu Sakai; Maiko Narahara; J B Brown; Yoshitaka Sato; Genta Sawada; Koshi Mimori; Sachiko Minamiguchi; Hironori Haga; Hiroshi Seno; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
Nature, Jan. 2019, Peer-reviewed

Genome-Wide Analysis of Non-Coding Alterations in Pan-Myeloid Cancers Using Whole Genome Sequencing
Nannya, Yasuhito; Yoshida, Kenichi; Zhao, Lanying; Takeda, June; Ueno, Hiroo; Yoshizato, Tetsuichi; Yoda, Akinori; Nakagawa, Masahiro; Makishima, Hideki; Tanaka, Hiroko; Hiramoto, Nobuhiro; Muto, Hideharu; Fuji, Shigeo; Polprasert, Chantana; Damm, Frederik; Usuki, Kensuke; Taguchi, Masataka; Chiba, Shigeru; Miyawaki, Shuichi; Shih, Lee-Yung; Tsurumi, Hisashi; Kasahara, Senji; Malcovati, Luca; Ishikawa, Takayuki; Jansen, Joop H; Miyazaki, Yasushi; Miyano, Satoru; Cazzola, Mario; Ogawa, Seishi
BLOOD, Nov. 2018

Constitutive Activation of the Canonical NF-κB Pathway Leads to Bone Marrow Failure and Induction of Erythroid Signature in Hematopoietic Stem Cells
Masahiro Marshall Nakagawa; Chozha Vendan Rathinam
Cell Reports, Nov. 2018, Peer-reviewed

A20 deficiency in multipotent progenitors perturbs quiescence of hematopoietic stem cells
Masahiro Marshall Nakagawa; Harry Davis; Chozha Vendan Rathinam
Stem Cell Research, Oct. 2018, Peer-reviewed

骨髄異形成症候群患者320例におけるDNAメチル化と遺伝子プロファイル(DNA methylation and genetic profiles in 320 patients with myelodysplastic syndromes)
森本俊; 牧島秀樹; 永田安伸; Baer Constance; Nadarajah Niroshan; Alpermann Tamara; 永江玄太; 南谷泰仁; 宮崎泰司; 吉田健一; 吉里哲一; 中川正宏; 稲垣良作; 竹田淳恵; 藤井陽一; 竹内康英; 白石友一; 千葉健一; 田中洋子; 眞田昌; 宮野悟; Haferlach Claudia; Kern Wolfgang; 油谷浩幸; Haferlach Torsten; 小川誠司
臨床血液, Sep. 2018, Peer-reviewed

A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia
H. Sakai; N. Hosono; H. Nakazawa; B. Przychodzen; C. Polprasert; H. E. Carraway; M. A. Sekeres; T. Radivoyevitch; K. Yoshida; M. Sanada; T. Yoshizato; K. Kataoka; M. M. Nakagawa; H. Ueno; Y. Nannya; A. Kon; Y. Shiozawa; J. Takeda; Y. Shiraishi; K. Chiba; S. Miyano; J. Singh; R. A. Padgett; S. Ogawa; J. P. Maciejewski; H. Makishima
Leukemia, 01 Mar. 2018, Peer-reviewed

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice
Ayana Kon; Satoshi Yamazaki; Yasuhito Nannya; Keisuke Kataoka; Yasunori Ota; Masahiro Marshall Nakagawa; Kenichi Yoshida; Yusuke Shiozawa; Maiko Morita; Tetsuichi Yoshizato; Masashi Sanada; Manabu Nakayama; Haruhiko Koseki; Hiromitsu Nakauchi; Seishi Ogawa
Blood, 08 Feb. 2018, Peer-reviewed

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.
Keisuke Kataoka; Masako Iwanaga; Jun-Ichirou Yasunaga; Yasunobu Nagata; Akira Kitanaka; Takuro Kameda; Makoto Yoshimitsu; Yuichi Shiraishi; Aiko Sato-Otsubo; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Yotaro Ochi; Kosuke Aoki; Hiromichi Suzuki; Yusuke Shiozawa; Tetsuichi Yoshizato; Yusuke Sato; Kenichi Yoshida; Kisato Nosaka; Masakatsu Hishizawa; Hidehiro Itonaga; Yoshitaka Imaizumi; Wataru Munakata; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Tsuyoshi Nakamaki; Ken Ishiyama; Shuichi Miyawaki; Ryohei Ishii; Osamu Nureki; Kensei Tobinai; Yasushi Miyazaki; Akifumi Takaori-Kondo; Tatsuhiro Shibata; Satoru Miyano; Kenji Ishitsuka; Atae Utsunomiya; Kazuya Shimoda; Masao Matsuoka; Toshiki Watanabe; Seishi Ogawa
Blood, 11 Jan. 2018, Peer-reviewed

Constitutive activation of NF-κB pathway in hematopoietic stem cells causes loss of quiescence and deregulated transcription factor networks
Nakagawa M.M; Chen H; Rathinam C.V
Frontiers in Cell and Developmental Biology, 2018, Peer-reviewed

Novel Mechanism of Post-Transcriptional Regulation of PD-L1 Expression By 3 '-UTR Binding Proteins
Kogure Y; Kataoka K; Adachi S; Watatani Y; Kon A; Yoshida K; Nakagawa M; Hatta T; Natsume T; Ogawa S
BLOOD, Dec. 2017, Peer-reviewed

コヒーシンサブユニットStag2は造血幹細胞の分化と自己複製を制御する
越智陽太郎; 昆彩奈; 吉田健一; 片岡圭亮; 中川正宏; 牧島秀樹; 古関明彦; 高折晃史; 小川誠司
日本癌学会総会記事, Sep. 2017

Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation
Tetsuichi Yoshizato; Yasuhito Nannya; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Hiromichi Suzuki; Yasunobu Nagata; Yusuke Sato; Nobuyuki Kakiuchi; Keitaro Matsuo; Makoto Onizuka; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Hiroo Ueno; Masahiro M. Nakagawa; Bartlomiej Przychodzen; Claudia Haferlach; Wolfgang Kern; Kosuke Aoki; Hidehiro Itonaga; Yoshinobu Kanda; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Torsten Haferlach; Yasushi Miyazaki; Keizo Horibe; Masashi Sanada; Satoru Miyano; Hideki Makishima; Seishi Ogawa
BLOOD, Apr. 2017, Peer-reviewed

Aberrant PD-L1 expression through 3 '-UTR disruption in multiple cancers
Keisuke Kataoka; Yuichi Shiraishi; Yohei Takeda; Seiji Sakata; Misako Matsumoto; Seiji Nagano; Takuya Maeda; Yasunobu Nagata; Akira Kitanaka; Seiya Mizuno; Hiroko Tanaka; Kenichi Chiba; Satoshi Ito; Yosaku Watatani; Nobuyuki Kakiuchi; Hiromichi Suzuki; Tetsuichi Yoshizato; Kenichi Yoshida; Masashi Sanada; Hidehiro Itonaga; Yoshitaka Imaizumi; Yasushi Totoki; Wataru Munakata; Hiromi Nakamura; Natsuko Hama; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Kyoko Masuda; Nagahiro Minato; Koichi Kashiwase; Koji Izutsu; Akifumi Takaori-Kondo; Yasushi Miyazaki; Satoru Takahashi; Tatsuhiro Shibata; Hiroshi Kawamoto; Yoshiki Akatsuka; Kazuya Shimoda; Kengo Takeuchi; Tsukasa Seya; Satoru Miyano; Seishi Ogawa
NATURE, Jun. 2016, Peer-reviewed

DYNAMICS OF CLONAL EVOLUTION IN MYELODYSPLASTIC SYNDROMES
H. Makishima; T. Yoshizato; K. Yoshida; T. LaFramboise; M. Ruffalo; M. Sekeres; H. Suzuki; B. Przychodzen; Y. Nagata; M. Meggendorfer; M. Sanada; Y. Okuno; Y. Sato; A. Sato-Otsubo; T. Radivoyevitch; N. Hosono; Y. Shiraishi; K. Chiba; C. Haferlach; W. Kern; H. Tanaka; Y. Shiozawa; I. Gomez-Segui; H. Husseinzadeh; S. Thota; K. Guinta; B. Dienes; T. Nakamaki; S. Miyawaki; Y. Saunthararajah; S. Chiba; S. Miyano; Ly Shih; T. Haferlach; S. Ogawa; J. Maciejewski
HAEMATOLOGICA, Jun. 2016

GENETIC FACTORS ASSOCIATED WITH EVOLUTION OF MYELODYSPLASTIC SYNDROMES TO SECONDARY CHRONIC MYELOMONOCYTIC LEUKEMIA
R. Saiki; T. Yoshizato; B. Przychodzen; K. Yoshida; M. A. Sekeres; Y. Nagata; M. Meggendorfer; M. Sanada; Y. Okuno; A. Kon; H. Suzuki; Y. Sato; Y. Shiraishi; K. Chiba; C. Haferlach; W. Kern; H. Tanaka; Y. Shiozawa; K. M. Guinta; T. Nakamaki; S. Miyawaki; Y. Saunthararajah; S. Chiba; S. Miyano; L. Y. Shih; A. F. List; S. Ogawa; T. Haferlach; J. P. Maciejewski; H. Makishima
HAEMATOLOGICA, Jun. 2016

Slicer Endonuclease Argonaute 2 Is a Negative Regulator of Hematopoietic Stem Cell Quiescence
Kenneth Lu; Masahiro Marshall Nakagawa; Keyur Thummar; Chozha Vendan Rathinam
STEM CELLS, May 2016, Peer-reviewed

Variegated RHOA mutations in adult T-cell leukemia/lymphoma
Yasunobu Nagata; Kenji Kontani; Terukazu Enami; Keisuke Kataoka; Ryohei Ishii; Yasushi Totoki; Tatsuki R. Kataoka; Masahiro Hirata; Kazuhiro Aoki; Kazumi Nakano; Akira Kitanaka; Mamiko Sakata-Yanagimoto; Sachiko Egami; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Yusuke Shiozawa; Tetsuichi Yoshizato; Hiromichi Suzuki; Ayana Kon; Kenichi Yoshida; Yusuke Sato; Aiko Sato-Otsubo; Masashi Sanada; Wataru Munakata; Hiromi Nakamura; Natsuko Hama; Satoru Miyano; Osamu Nureki; Tatsuhiro Shibata; Hironori Haga; Kazuya Shimoda; Toshiaki Katada; Shigeru Chiba; Toshiki Watanabe; Seishi Ogawa
BLOOD, Feb. 2016, Peer-reviewed

Genomic landscape of liposarcoma
Deepika Kanojia; Yasunobu Nagata; Manoj Garg; Dhong Hyun Lee; Aiko Sato; Kenichi Yoshida; Yusuke Sato; Masashi Sanada; Anand Mayakonda; Christoph Bartenhagen; Hans-Ulrich Klein; Ngan B. Doan; Jonathan W. Said; S. Mohith; Swetha Gunasekar; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Ola Myklebost; Henry Yang; Martin Dugas; Leonardo A. Meza-Zepeda; Allan W. Silberman; Charles Forscher; Jeffrey W. Tyner; Seishi Ogawa; H. Phillip Koeffler
ONCOTARGET, Dec. 2015, Peer-reviewed
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Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms
R. J. Molenaar; S. Thota; Y. Nagata; B. Patel; M. Clemente; B. Przychodzen; C. Hirsh; A. D. Viny; N. Hosano; F. E. Bleeker; M. Meggendorfer; T. Alpermann; Y. Shiraishi; K. Chiba; H. Tanaka; C. J. F. van Noorden; T. Radivoyevitch; H. E. Carraway; H. Makishima; S. Miyano; M. A. Sekeres; S. Ogawa; T. Haferlach; J. P. Maciejewski
LEUKEMIA, Nov. 2015, Peer-reviewed

Integrated molecular analysis of adult T cell leukemia/lymphoma
Keisuke Kataoka; Yasunobu Nagata; Akira Kitanaka; Yuichi Shiraishi; Teppei Shimamura; Jun-Ichirou Yasunaga; Yasushi Totoki; Kenichi Chiba; Aiko Sato-Otsubo; Genta Nagae; Ryohei Ishii; Satsuki Muto; Shinichi Kotani; Yosaku Watatani; June Takeda; Masashi Sanada; Hiroko Tanaka; Hiromichi Suzuki; Yusuke Sato; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Yoshida; Hideki Makishima; Masako Iwanaga; Guangyong Ma; Kisato Nosaka; Masakatsu Hishizawa; Hidehiro Itonaga; Yoshitaka Imaizumi; Wataru Munakata; Hideaki Ogasawara; Toshitaka Sato; Ken Sasai; Kenzo Muramoto; Marina Penova; Takahisa Kawaguchi; Hiromi Nakamura; Natsuko Hama; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Tsuyoshi Nakamaki; Ken Ishiyama; Shuichi Miyawaki; Sung-Soo Yoon; Kensei Tobinai; Yasushi Miyazaki; Akifumi Takaori-Kondo; Fumihiko Matsuda; Kengo Takeuchi; Osamu Nureki; Hiroyuki Aburatani; Toshiki Watanabe; Tatsuhiro Shibata; Masao Matsuoka; Satoru Miyano; Kazuya Shimoda; Seishi Ogawa
NATURE GENETICS, Nov. 2015, Peer-reviewed

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
T. Yoshizato; B. Dumitriu; K. Hosokawa; H. Makishima; K. Yoshida; D. Townsley; A. Sato-Otsubo; Y. Sato; D. Liu; H. Suzuki; C. O. Wu; Y. Shiraishi; M. J. Clemente; K. Kataoka; Y. Shiozawa; Y. Okuno; K. Chiba; H. Tanaka; Y. Nagata; T. Katagiri; A. Kon; M. Sanada; P. Scheinberg; S. Miyano; J. P. Maciejewski; S. Nakao; N. S. Young; S. Ogawa
NEW ENGLAND JOURNAL OF MEDICINE, Jul. 2015, Peer-reviewed
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Mutational landscape and clonal architecture in grade II and III gliomas
Hiromichi Suzuki; Kosuke Aoki; Kenichi Chiba; Yusuke Sato; Yusuke Shiozawa; Yuichi Shiraishi; Teppei Shimamura; Atsushi Niida; Kazuya Motomura; Fumiharu Ohka; Takashi Yamamoto; Kuniaki Tanahashi; Melissa Ranjit; Toshihiko Wakabayashi; Tetsuichi Yoshizato; Keisuke Kataoka; Kenichi Yoshida; Yasunobu Nagata; Aiko Sato-Otsubo; Hiroko Tanaka; Masashi Sanada; Yutaka Kondo; Hideo Nakamura; Masahiro Mizoguchi; Tatsuya Abe; Yoshihiro Muragaki; Reiko Watanabe; Ichiro Ito; Satoru Miyano; Atsushi Natsume; Seishi Ogawa
NATURE GENETICS, May 2015, Peer-reviewed

Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence
Masahiro Marshall Nakagawa; Keyur Thummar; Jonathan Mandelbaum; Laura Pasqualucci; Chozha Vendan Rathinam
JOURNAL OF EXPERIMENTAL MEDICINE, Feb. 2015, Peer-reviewed

Evil defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
T. Sato; S. Goyama; K. Kataoka; R. Nasu; T. Tsuruta-Kishino; Y. Kagoya; A. Nukina; K. Kumagai; N. Kubota; M. Nakagawa; S. Arai; A. Yoshimi; H. Honda; T. Kadowaki; M. Kurokawa
ONCOGENE, Oct. 2014, Peer-reviewed

Recurrent CDC25C mutations drive malignant transformation in FPD/AML
Akihide Yoshimi; Takashi Toya; Masahito Kawazu; Toshihide Ueno; Ayato Tsukamoto; Hiromitsu Iizuka; Masahiro Nakagawa; Yasuhito Nannya; Shunya Arai; Hironori Harada; Kensuke Usuki; Yasuhide Hayashi; Etsuro Ito; Keita Kirito; Hideaki Nakajima; Motoshi Ichikawa; Hiroyuki Mano; Mineo Kurokawa
NATURE COMMUNICATIONS, Aug. 2014, Peer-reviewed

Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome
Yusuke Sato; Shigekatsu Maekawa; Ryohei Ishii; Masashi Sanada; Teppei Morikawa; Yuichi Shiraishi; Kenichi Yoshida; Yasunobu Nagata; Aiko Sato-Otsubo; Tetsuichi Yoshizato; Hiromichi Suzuki; Yusuke Shiozawa; Keisuke Kataoka; Ayana Kon; Kosuke Aoki; Kenichi Chiba; Hiroko Tanaka; Haruki Kume; Satoru Miyano; Masashi Fukayama; Osamu Nureki; Yukio Homma; Seishi Ogawa
SCIENCE, May 2014, Peer-reviewed

Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16
Koki Ueda; Akihide Yoshimi; Yuki Kagoya; Satoshi Nishikawa; Victor E. Marquez; Masahiro Nakagawa; Mineo Kurokawa
CANCER SCIENCE, May 2014, Peer-reviewed

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
T. Haferlach; Y. Nagata; V. Grossmann; Y. Okuno; U. Bacher; G. Nagae; S. Schnittger; M. Sanada; A. Kon; T. Alpermann; K. Yoshida; A. Roller; N. Nadarajah; Y. Shiraishi; Y. Shiozawa; K. Chiba; H. Tanaka; H. P. Koeffler; H-U Klein; M. Dugas; H. Aburatani; A. Kohlmann; S. Miyano; C. Haferlach; W. Kern; S. Ogawa
LEUKEMIA, Feb. 2014, Peer-reviewed

Positive feedback between NF-kappa B and TNF-alpha promotes leukemia-initiating cell capacity
Yuki Kagoya; Akihide Yoshimi; Keisuke Kataoka; Masahiro Nakagawa; Keiki Kumano; Shunya Arai; Hiroshi Kobayashi; Taku Saito; Yoichiro Iwakura; Mineo Kurokawa
JOURNAL OF CLINICAL INVESTIGATION, Feb. 2014, Peer-reviewed

Intracellular Reactive Oxygen Species Mark and Influence the Megakaryocyte-Erythrocyte Progenitor Fate of Common Myeloid Progenitors
Akihito Shinohara; Yoichi Imai; Masahiro Nakagawa; Tsuyoshi Takahashi; Motoshi Ichikawa; Mineo Kurokawa
STEM CELLS, Feb. 2014, Peer-reviewed

NF-κB/TNF-α positive feedback loop with active proteasome machinery supports myeloid leukemia initiating cell capacity.
Kagoya Y; Yoshimi A; Kataoka K; Nakagawa M; Kumano K; Arai S; Kobayashi H; Saito T; Iwakura Y; Kurokawa M
The Journal of Clinical Investigation, 2014, Peer-reviewed

The landscape of somatic mutations in Down syndrome-related myeloid disorders
Kenichi Yoshida; Tsutomu Toki; Yusuke Okuno; Rika Kanezaki; Yuichi Shiraishi; Aiko Sato-Otsubo; Masashi Sanada; Myoung-ja Park; Kiminori Terui; Hiromichi Suzuki; Ayana Kon; Yasunobu Nagata; Yusuke Sato; RuNan Wang; Norio Shiba; Kenichi Chiba; Hiroko Tanaka; Asahito Hama; Hideki Muramatsu; Daisuke Hasegawa; Kazuhiro Nakamura; Hirokazu Kanegane; Keiko Tsukamoto; Souichi Adachi; Kiyoshi Kawakami; Koji Kato; Ryosei Nishimura; Shai Izraeli; Yasuhide Hayashi; Satoru Miyano; Seiji Kojima; Etsuro Ito; Seishi Ogawa
NATURE GENETICS, Nov. 2013, Peer-reviewed

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
Susumu Goyama; Janet Schibler; Lea Cunningham; Yue Zhang; Yalan Rao; Nahoko Nishimoto; Masahiro Nakagawa; Andre Olsson; Mark Wunderlich; Kevin A. Link; Benjamin Mizukawa; H. Leighton Grimes; Mineo Kurokawa; P. Paul Liu; Gang Huang; James C. Mulloy
JOURNAL OF CLINICAL INVESTIGATION, Sep. 2013, Peer-reviewed

A role for RUNX1 in hematopoiesis and myeloid leukemia.
Motoshi Ichikawa; Akihide Yoshimi; Masahiro Nakagawa; Nahoko Nishimoto; Naoko Watanabe-Okochi; Mineo Kurokawa
International journal of hematology, Jun. 2013, Peer-reviewed

Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy
Sho Hangai; Fumihiko Nakamura; Yasuhiko Kamikubo; Akira Honda; Shunya Arai; Masahiro Nakagawa; Motoshi Ichikawa; Mineo Kurokawa
ANNALS OF HEMATOLOGY, May 2013, Peer-reviewed

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation
Mayumi Yoshimi; Susumu Goyama; Masahito Kawazu; Masahiro Nakagawa; Motoshi Ichikawa; Yoichi Imai; Keiki Kumano; Takashi Asai; James C. Mulloy; Andrew S. Kraft; Tsuyoshi Takahashi; Naoki Shirafuji; Mineo Kurokawa
EUROPEAN JOURNAL OF IMMUNOLOGY, Apr. 2012, Peer-reviewed

The first case of blastic plasmacytoid dendritic cell neoplasm with MLL-ENL rearrangement
Takashi Toya; Nahoko Nishimoto; Junji Koya; Masahiro Nakagawa; Fumihiko Nakamura; Koji Kandabashi; Go Yamamoto; Yasuhito Nannya; Motoshi Ichikawa; Mineo Kurokawa
LEUKEMIA RESEARCH, Jan. 2012, Peer-reviewed

Early-onset Therapy-related Myelodysplastic Syndrome Originating from Prolonged Myelosuppression after Fludarabine-based Therapy
Sho Yamazaki; Fumihiko Nakamura; Yasuhito Nannya; Masahiro Nakagawa; Motoshi Ichikawa; Mineo Kurokawa
INTERNAL MEDICINE, 2012, Peer-reviewed

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-kappa B signaling in the repression of myeloid tumors
Masahiro Nakagawa; Munetake Shimabe; Naoko Watanabe-Okochi; Shunya Arai; Akihide Yoshimi; Akihito Shinohara; Nahoko Nishimoto; Keisuke Kataoka; Tomohiko Sato; Keiki Kumano; Yasuhito Nannya; Motoshi Ichikawa; Yoichi Imai; Mineo Kurokawa
BLOOD, Dec. 2011, Peer-reviewed

Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida; Masashi Sanada; Yuichi Shiraishi; Daniel Nowak; Yasunobu Nagata; Ryo Yamamoto; Yusuke Sato; Aiko Sato-Otsubo; Ayana Kon; Masao Nagasaki; George Chalkidis; Yutaka Suzuki; Masashi Shiosaka; Ryoichiro Kawahata; Tomoyuki Yamaguchi; Makoto Otsu; Naoshi Obara; Mamiko Sakata-Yanagimoto; Ken Ishiyama; Hiraku Mori; Florian Nolte; Wolf-Karsten Hofmann; Shuichi Miyawaki; Sumio Sugano; Claudia Haferlach; H. Phillip Koeffler; Lee-Yung Shih; Torsten Haferlach; Shigeru Chiba; Hiromitsu Nakauchi; Satoru Miyano; Seishi Ogawa
NATURE, Oct. 2011, Peer-reviewed

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19(ARF)
Nahoko Nishimoto; Shunya Arai; Motoshi Ichikawa; Masahiro Nakagawa; Susumu Goyama; Keiki Kumano; Tsuyoshi Takahashi; Yasuhiko Kamikubo; Yoichi Imai; Mineo Kurokawa
BLOOD, Sep. 2011, Peer-reviewed

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells
Shunya Arai; Akihide Yoshimi; Munetake Shimabe; Motoshi Ichikawa; Masahiro Nakagawa; Yoichi Imai; Susumu Goyama; Mineo Kurokawa
BLOOD, Jun. 2011, Peer-reviewed

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins
Akihide Yoshimi; Susumu Goyama; Naoko Watanabe-Okochi; Yumiko Yoshiki; Yasuhito Nannya; Eriko Nitta; Shunya Arai; Tomohiko Sato; Munetake Shimabe; Masahiro Nakagawa; Yoichi Imai; Toshio Kitamura; Mineo Kurokawa
BLOOD, Mar. 2011, Peer-reviewed

Disseminated tuberculosis following unrelated cord blood transplantation for refractory peripheral T-cell lymphoma: Clinical role of serum procalcitonin levels
J. Koya; Y. Nannya; T. Yoshizato; K. Ono; S. Seo; M. Nakagawa; M. Ichikawa; M. Kurokawa
JOURNAL OF INFECTION, Mar. 2011, Peer-reviewed

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
Keisuke Kataoka; Tomohiko Sato; Akihide Yoshimi; Susumu Goyama; Takako Tsuruta; Hiroshi Kobayashi; Munetake Shimabe; Shunya Arai; Masahiro Nakagawa; Yoichi Imai; Keiki Kumano; Katsuyoshi Kumagai; Naoto Kubota; Takashi Kadowaki; Mineo Kurokawa
JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2011, Peer-reviewed

AML1 enhances the expression of leukotriene B-4 type-1 receptor in leukocytes
Tomomi Hashidate; Naoka Murakami; Masahiro Nakagawa; Motoshi Ichikawa; Mineo Kurokawa; Takao Shimizu; Motonao Nakamura
FASEB JOURNAL, Sep. 2010, Peer-reviewed

T cell acute lymphoblastic leukemia arising from familial platelet disorder
Nahoko Nishimoto; Yoichi Imai; Koki Ueda; Masahiro Nakagawa; Akihito Shinohara; Motoshi Ichikawa; Yasuhito Nannya; Mineo Kurokawa
INTERNATIONAL JOURNAL OF HEMATOLOGY, Jul. 2010, Peer-reviewed

The Pathogenetic Significance of Deregulated Transcription Factors in Hematological Malignancies
Masahiro Nakagawa; Susumu Goyama; Motoshi Ichikawa; Mineo Kurokawa
SYSTEMS BIOLOGY: THE CHALLENGE OF COMPLEXITY, 2009, Peer-reviewed

Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-beta signaling
Tomohiko Sato; Susumu Goyama; Eriko Nitta; Masataka Takeshita; Mayumi Yoshimi; Masahiro Nakagawa; Masahito Kawazu; Motoshi Ichikawa; Mineo Kurokawa
CANCER SCIENCE, Jul. 2008, Peer-reviewed

AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis
Motoshi Ichikawa; Susumu Goyama; Takashi Asai; Masahito Kawazu; Masahiro Nakagawa; Masataka Takeshita; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa
JOURNAL OF IMMUNOLOGY, Apr. 2008, Peer-reviewed

Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development
Masahito Kawazu; Go Yamamoto; Mayumi Yoshimi; Kazuki Yamamoto; Takashi Asai; Motoshi Ichikawa; Sachiko Seo; Masahiro Nakagawa; Shigeru Chiba; Mineo Kurokawa; Seishi Ogawa
JOURNAL OF IMMUNOLOGY, Oct. 2007, Peer-reviewed

AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis
Masahiro Nakagawa; Motoshi Ichikawa; Keiki Kumano; Susumu Goyama; Masahito Kawazu; Takashi Asai; Seishi Ogawa; Mineo Kurokawa; Shigeru Chiba
BLOOD, Nov. 2006, Peer-reviewed

High-grade cytomegalovirus antigenemia after hematopoietic stem cell transplantation
Y Asano-Mori; K Oshima; M Sakata-Yanagimoto; M Nakagawa; K Kandabashi; K Izutsu; A Hangaishi; T Motokura; S Chiba; M Kurokawa; H Hirai; Y Kanda
BONE MARROW TRANSPLANTATION, Nov. 2005, Peer-reviewed

In vivo alemtuzumab enables haploidentical human leukocyte antigen-mismatched hematopoietic stem-cell transplantation without ex vivo graft manipulation
Y Kanda; K Oshima; Y Asano-Mori; K Kandabashi; M Nakagawa; M Sakata-Yanagimoto; K Izutsu; A Hangaishi; S Tsujino; S Ogawa; T Motokura; S Chiba; H Hirai
TRANSPLANTATION, May 2005, Peer-reviewed

The transcriptionafly active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region
S Goyama; Y Yamaguchi; Y Imai; M Kawazu; M Nakagawa; T Asai; K Kumano; K Mitani; S Ogawa; S Chiba; M Kurokawa; H Hirai
BLOOD, Dec. 2004, Peer-reviewed

Clinical significance of peripheral blood erythroblastosis after hematopoietic stem cell transplantation
S Goyama; Y Kanda; Y Nannya; S Ogawa; Y Asano-Moki; N Ogawa; M Nakagawa; M Sakata-Yanagimoto; M Kawazu; Y Komeno; Y Imai; A Hangaishi; M Kurokawa; S Tsujino; K Aoki; S Chiba; T Motokura; H Hirai
LEUKEMIA & LYMPHOMA, Dec. 2004, Peer-reviewed

Predictors for severe cardiac complications after hematopoietic stem cell transplantation
M Sakata-Yanagimoto; Y Kanda; M Nakagawa; Y Asano-Mori; K Kandabashi; K Izutsu; Y Imai; A Hangaishi; M Kurokawa; S Tsujino; S Ogawa; S Chiba; T Motokura; H Hirai
BONE MARROW TRANSPLANTATION, May 2004, Peer-reviewed

Increased incidence of acute graft-versus-host disease with the continuous infusion of cyclosporine A compared to twice-daily infusion
N Ogawa; Y Kanda; M Matsubara; Y Asano; M Nakagawa; M Sakata-Yanagimoto; K Kandabashi; K Izutsu; Y Imai; A Hangaishi; M Kurokawa; S Tsujino; S Ogawa; K Aoki; S Chiba; T Motokura; H Hirai
BONE MARROW TRANSPLANTATION, Mar. 2004, Peer-reviewed

Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation
Y Asano; Y Kanda; N Ogawa; M Sakata-Yanagimoto; M Nakagawa; M Kawazu; S Goyama; K Kandabashi; K Izutsu; Y Imai; A Hangaishi; M Kurokawa; S Tsujino; S Ogawa; K Aoki; S Chiba; T Motokura; H Hirai
BONE MARROW TRANSPLANTATION, Dec. 2003, Peer-reviewed

Misc.

クローン性造血における遺伝子変異とコピー数異常の統合解析
佐伯龍之介; 桃沢幸秀; 南谷泰仁; 中川正宏; 中川正宏; 越智陽太郎; 吉里哲一; 白石友一; 田中洋子; 新井田厚司; 井元清哉; 松田浩一; 村上善則; 松田秀一; 宮野悟; 牧島秀樹; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 2021

赤白血病におけるゲノム解析と治療標的の検討
竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; 越智陽太郎; 中川正宏; 佐伯龍之介; 白石友一; 永田安伸; 高折晃史; 千葉滋; 片岡圭亮; 宮野悟; 牧島秀樹; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 2021

乳管上皮増殖性病変から乳癌へ至るクローン進化
西村友美; 西村友美; 垣内伸之; 吉田健一; 竹内康英; 竹内康英; 前田紘奈; 前田紘奈; 塩澤裕介; 中川正宏; 越智陽太郎; 佐伯龍之介; 川田有希子; 川田有希子; 片岡竜貴; 片岡竜貴; 桜井孝規; 桜井孝規; 馬場郷子; 白石友一; 千葉健一; 竹内賢吾; 羽賀博典; 宮野悟; 戸井雅和; 小川誠司
日本乳癌学会学術総会プログラム・抄録集, 2021

A NOVEL GENETIC AND MORPHOLOGIC PHENOTYPE OF ARID2-MEDIATED MYELODYSPLASTIC SYNDROMES
H. Sakai; N. Hosono; H. Nakazawa; B. Przychodzen; C. Polprasert; H. Carraway; M. Sekeres; T. Radivoyevitch; K. Yoshida; M. Sanada; T. Yoshizato; K. Kataoka; M. Nakagawa; H. Ueno; Y. Nannya; K. Ayana; Y. Shiozawa; J. Takeda; Y. Shiraishi; K. Chiba; S. Miyano; J. Singh; R. Padgett; S. Ogawa; J. Maciejewski; H. Makishima
HAEMATOLOGICA, Jun. 2017

Targeting the Osteoblast in Myelodysplasia and Acute Myeloid Leukemia
Masahiro Marshall Nakagawa; Aruna Kode; Sanil J. Manavalan; Govind Bhagat; Julie Teruya-Feldstein; Azra Raza; Ellin Berman; Stavroula Kousteni
BLOOD, Dec. 2015

Recurrent CDC25C mutations drive malignant transformation in FPD/AML
Akihide Yoshimi; Takashi Toya; Masahito Kawazu; Toshihide Ueno; Ayato Tsukamoto; Hiromitsu Iizuka; Masahiro Nakagawa; Yasuhito Nannya; Shunya Arai; Motoshi Ichikawa; Hironori Harada; Kensuke Usuki; Yasuhide Hayashi; Etsuro Ito; Keita Kirito; Hideaki Nakajima; Hiroyuki Mano; Mineo Kurokawa
CANCER RESEARCH, Oct. 2014

Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Tomohiko Sato; Susumu Goyama; Keisuke Kataoka; Ryo Nasu; Takako Tsuruta-Kishino; Yuki Kagoya; Arika Nukina; Katsuyoshi Kumagai; Naoto Kubota; Masahiro Nakagawa; Shunya Arai; Akihide Yoshimi; Hiroaki Honda; Takashi Kadowaki; Mineo Kurokawa
CANCER RESEARCH, Oct. 2014

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells (vol 123, pg 3876, 2013)
Susumu Goyama; Janet Schibler; Lea Cunningham; Yue Zhang; Yalan Rao; Nahoko Nishimoto; Masahiro Nakagawa; Andre Olsson; Mark Wunderlich; Kevin A. Link; Benjamin Mizukawa; H. Leighton Grimes; Mineo Kurokawa; P. Paul Liu; Gang Huang; James C. Mulloy
JOURNAL OF CLINICAL INVESTIGATION, Nov. 2013

Inhibition of EZH2 Depletes MLL Fusion Leukemia Stem Cells Through Restoration of p16 Expression
Koki Ueda; Akihide Yoshimi; Masahiro Nakagawa; Satoshi Nishikawa; Victor E. Marquez; Keiki Kumano; Mineo Kurokawa
BLOOD, Nov. 2012

Regulation of Chronic Myelogenous Leukemia Stem Cells by Leukemia Oncogene Evi1
Tomohiko Sato; Susumu Goyama; Keisuke Kataoka; Takako Tsuruta; Masahiro Nakagawa; Keiki Kumano; Katsuyoshi Kumagai; Naoto Kubota; Takashi Kadowaki; Mineo Kurokawa
BLOOD, Nov. 2011

BAALC Regulates Hematopoietic Stem Cells Through P53 and Promotes Leukemia with Impaired P53 Function
Sumimasa Nagai; Keiki Kumano; Akihito Shinohara; Masahiro Nakagawa; Motoshi Ichikawa; Mineo Kurokawa
BLOOD, Nov. 2011

Notch-Runx pathway in mammalian hematopoiesis
中川正宏
血液・腫瘍科, Jul. 2007

High-grade CMV antigenemia after hematopoietic stem cell transplantation: Risk factor and outcome.
Y Asano; Y Kanda; MS Yanagimoto; M Nakagawa; K Kandabashi; K Izutsu; Y Imai; A Hangaishi; M Kurokawa; S Tsujino; S Ogawa; S Chiba; T Motokura; H Hirai
BLOOD, Nov. 2003

Amplified EPOR/JAK2 genes definea unique subtype of acute erythroid leukemia.
June Takeda; Kenichi Yoshida; Masahiro M. Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
CANCER RESEARCH, Jun. 2022

Novel Molecular Pathogenesis and Therapeutic Target in Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Yasuhito Nannya; Lee-Yung Shih; Ayana Kon; Akinori Yoda; Yotaro Ochi; Yusuke Shiozawa; Tetsuichi Yoshizato; Cassandra M. Kerr; Yuichi Shiraishi; Kenichi Chiba; Yasunobu Nagata; Akira Hangaishi; Toshiyuki Kitano; Ken Ishiyama; Hisashi Tsurumi; Yasushi Miyazaki; Nobuhiro Hiramoto; Takayuki Ishikawa; Akifumi Takaori-Kondo; Masahiro Nakagawa; Masashi Sanada; Hideyuki Nakazawa; Keisuke Kataoka; Ryunosuke Saiki; Hiroko Tanaka; Kensuke Usuki; Shuichi Miyawaki; Satoru Miyano; Arnold Ganser; Michael Heuser; Jaroslaw P. Maciejewski; Felicitas Thol; Hideki Makishima; Seishi Ogawa
BLOOD, Nov. 2019

Chronology and risk dependence of age-related remodelling of oesophageal epithelia
Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M. Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Shinya Ohashi; Shin'ichi Miyamoto; Shigeru Tsunoda; Koshi Mimori; Sachiko Minamiguchi; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
CANCER RESEARCH, Jul. 2019

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Masahiro Marshall Nakagawa; Yasuhito Nannya; Akinori Yoda; Daisuke Morishita; Ryunosuke Saiki; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M. Kerr; Yasunobu Nagata; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
BLOOD, Nov. 2021

Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Akinori Yoda; Lee-Yung Shih; Yasuhito Nannya; Yotaro Ochi; Ayana Kon; Kenichi Chiba; Yuichi Shiraishi; Yusuke Shiozawa; Tetsuichi Yoshizato; Cassandra M. Kerr; Yasunobu Nagata; Toshiyuki Kitano; Akira Hangaishi; Ken Ishiyama; Hisashi Tsurumi; Yasushi Miyazaki; Nobuhiro Hiramoto; Takayuki Ishikawa; Masahiro Marshall Nakagawa; Akifumi Takaori-Kondo; Shigeru Chiba; Hideyuki Nakazawa; Ming-Chung Kuo; Keisuke Kataoka; Ryunosuke Saiki; Hiroko Tanaka; Kensuke Usuki; Shuichi Miyawaki; Satoru Miyano; Jaroslaw P. Maciejewski; Arnold Ganser; Michael Heuser; Felicitas Thol; Hideki Makishima; Seishi Ogawa
BLOOD, Nov. 2020

The molecular pathogenesis of DDX41-mutated myeloid neoplasms
昆彩奈; 中川正宏; 片岡圭亮; 片岡圭亮; 稲垣良作; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本血液学会学術集会抄録(Web), 2021

骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明
昆彩奈; 中川正宏; 片岡圭亮; 片岡圭亮; 稲垣良作; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会学術総会抄録集(Web), 2021

変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 吉里哲一; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 2021

The functional role of compound DDX41 germline and somatic R525H mutations in the development of myeloid neoplasms
Ayana Kon; Masahiro Nakagawa; Ryosaku Inagaki; Keisuke Kataoka; Yotaro Ochi; Hideki Makishima; Manabu Nakayama; Haruhiko Koseki; Yasuhito Nannya; Seishi Ogawa
CANCER SCIENCE, Feb. 2021

Early Clonal evolution of myeloid malignancies
Masahiro Nakagawa; Ryosaku Inagaki; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Xingxing Qi; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shinichi Matsuda; Seishi Ogawa
CANCER SCIENCE, Feb. 2021

JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Akinori Yoda; Yasuhito Nannya; Masahiro Nakagawa; Yotaro Ochi; Ayana Kon; Tetsuichi Yoshizato; Yusuke Shiozawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Satoru Miyano; Hideki Makishima; Seishi Ogawa
CANCER SCIENCE, Feb. 2021

Functional Characterization of Compound DDX41 Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies
Ayana Kon; Masahiro Marshall Nakagawa; Ryosaku Inagaki; Keisuke Kataoka; Hideki Makishima; Yotaro Ochi; Manabu Nakayama; Haruhiko Koseki; Yasuhito Nannya; Seishi Ogawa
BLOOD, Nov. 2020

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method
Masahiro Marshall Nakagawa; Ryosaku Inagaki; Yutaka Kuroda; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Qi Xingxing; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shuichi Matsuda; Seishi Ogawa
BLOOD, Nov. 2020

単一細胞でのRNA/DNA同時シーケンスによるクローン造血の病態解明
中川正宏; 中川正宏; 稲垣良作; 稲垣良作; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
日本血液学会学術集会抄録(Web), 2020

Clonal evolution of proliferative lesions into breast cancers
西村友美; 西村友美; 垣内伸之; 吉田健一; 竹内康英; 竹内康英; 前田紘奈; 前田紘奈; 塩澤裕介; 中川正宏; 越智陽太郎; 川田有希子; 川田有希子; 平田勝啓; 片岡竜貴; 桜井孝規; 馬場郷子; 白石友一; 千葉健一; 竹内賢吾; 羽賀博典; 宮野悟; 戸井雅和; 小川誠司
日本乳癌学会学術総会プログラム・抄録集, 2020

潰瘍性大腸炎における上皮細胞の陽性選択
垣内伸之; 垣内伸之; 内野基; 木原多佳子; 赤木宏太朗; 井上善景; 長山聡; 横山顕礼; 平野智紀; 平野智紀; 竹内康英; 竹内康英; 越智陽太郎; 塩澤裕介; 片岡圭亮; 中川正宏; 依田成玄; 南谷泰仁; 牧島秀樹; 白石友一; 千葉健一; 真田昌; 三好弘之; 坂井義治; 桜井孝規; 羽賀博典; 廣田誠一; 池内浩基; 竹内理; 宮野悟; 妹尾浩; 小川誠司
日本分子生物学会年会プログラム・要旨集(Web), 2019

Combined Stag2/Runx1 loss causes myelodysplatic syndrome through perturbed enhancer interactions
越智陽太郎; 越智陽太郎; 昆彩奈; 中川正宏; 片岡圭亮; 古関明彦; 佐伯龍之介; 吉里哲一; 吉田健一; 依田成玄; 鈴木洋; 鶴山竜昭; 牧島秀樹; 塩澤裕介; 南谷泰仁; 杉原英志; 佐藤孝明; 真田昌; 高折晃史; 宮野悟; 小川誠司
日本癌学会学術総会抄録集(Web), 2019

DNA Methylation and Genetic Profiles in 320 Patients with Myelodysplastic Syndromes
Suguru Morimoto; Hideki Makishima; Yasunobu Nagata; Niroshan Nadarajah; Constance Baer; Tamara Alpermann; Genta Nagae; Yasuhito Nannya; Yasushi Miyazaki; Kenichi Yoshida; Tetsuichi Yoshizato; Masahiro Marshall Nakagawa; Ryosaku Inagaki; June Takeda; Yoichi Fujii; Yasuhide Takeuchi; Hiroo Ueno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Satoru Miyano; Claudia Haferlach; Wolfgang Kern; Hiroyuki Aburatani; Torsten Haferlach; Seishi Ogawa
BLOOD, Nov. 2018

Cohesin subunit Stag2 regulates hematopoietic differentiation and self-renewal
Yotaro Ochi; Ayana Kon; Kenichi Yoshida; Keisuke Kataoka; Masahiro Marshall Nakagawa; Hideki Makishima; Haruhiko Koseki; Akifumi Takaori-Kondo; Seishi Ogawa
CANCER SCIENCE, Jan. 2018

Stag2 regulates Hematopoietic Differentiation and Self-Renewal
Yotaro Ochi; Ayana Kon; Kenichi Yoshida; Keisuke Kataoka; Masahiro Marshall Nakagawa; Hideki Makishima; Manabu Nakayama; Haruhiko Koseki; Akifumi Takaori-Kondo; Seishi Ogawa
BLOOD, Dec. 2017

The genetic aberrations in carcinogenic sequence of colitis-associated cancer
Nobuyuki Kakiuchi; Kenichi Yoshida; Yusuke Shiozawa; Akira Yokoyama; Keisuke Kataoka; Yoshikage Inoue; Yasuhide Takeuchi; Yasunori Kogure; Ayana Kon; Masahiro Nakagawa; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Kenji Kawada; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Hiroshi Nakase; Motoi Uchino; Hiroki Ikeuchi; Takako Kihara; Seiichi Hirota; Takahiro Horimatsu; Minoru Matsuura; Hiroyuki Marusawa; Hiroshi Seno; Seishi Ogawa
CANCER RESEARCH, Jul. 2017

ATLにおけるPD‐L13′‐UTR異常とその活性化メカニズムの解明
木暮泰寛; 片岡圭亮; 足達俊吾; 綿谷陽作; 昆彩奈; 吉田健一; 中川正宏; 八田知久; 夏目徹; 小川誠司
日本HTLV‐1学会学術集会, 2017

リンパ腫の治療が奏功せず,急性骨髄性白血病の治療が奏功した芽球形質細胞様樹状細胞腫瘍の1例
遠矢嵩; 西本菜穂子; 古屋淳史; 中川正宏; 増田亜希子; 神田橋宏治; 山本豪; 南谷泰仁; 市川幹; 黒川峰夫
臨床血液, 30 Mar. 2011

造血前駆細胞の転写制御機構を手がかりとした骨髄異形成症候群の病態解明
市川幹; 中川正宏
医科学応用研究財団研究報告, Feb. 2011

A Critical Role of Reactive Oxygen Species In the Generation of Megakaryocyte-Erythrocyte Progenitor Cells
Akihito Shinohara; Yoichi Imai; Masahiro Nakagawa; Tsuyoshi Takahashi; Motoshi Ichikawa; Mineo Kurokawa
BLOOD, Nov. 2010

AML1/RUNX1 FUNCTIONS AS A CYTOPLASMIC ATTENUATOR OF NF-KB SIGNALING IN THE REPRESSION OF MYELOID TUMORS
M. Nakagawa; M. Shimabe; S. Arai; N. Watanabeo-Okochi; A. Yoshimi; N. Nishimoto; M. Ichikawa; Y. Nannya; Y. Imai; M. Kurokawa
EXPERIMENTAL HEMATOLOGY, Sep. 2010

AML1/Runx1 Is a Cytoplasmic Attenuator of NF-Kb Signaling: Implication in Pathogenesis and Targeted Therapy of AML1-Related Leukemia.
Masahiro Nakagawa; Munetake Shimabe; Nahoko Nishimoto; Naoko Watanabe-Okochi; Motoshi Ichikawa; Yasuhito Nannya; Yoichi Imai; Mineo Kurokawa
BLOOD, Nov. 2009

造血幹細胞におけるAML1/Runx1の転写標的ネットワークの解明
中川正宏; 今井陽一; 市川幹; 浅井隆司; 黒川峰夫
臨床血液, 30 Sep. 2008

AML1による造血幹細胞制御と白血病発症機構
西本菜穂子; 市川幹; 中川正宏; 合山進; 高橋強志; 今井陽一; 黒川峰夫
臨床血液, 30 Sep. 2008

骨髄異形成症候群における造血幹細胞異常の分子機構の解明
市川幹; 中川正宏
研究結果報告書集, 2008

Phosphorylation of AML1/Runx1 is essential for T cell differentiation and early hematopoietic development
Mayumi Yoshimi; Susumu Goyama; Masahiro Nakagawa; Takashi Asai; Motoshi Ichikawa; Mineo Kurokawa
BLOOD, Nov. 2007

Implication of AML1/RUNX1 function in the homeostasis and leukemic transformation of hematopoietic stem cells
Motoshi Ichikawa; Masataka Takeshita; Susumu Goyama; Takashi Asai; Eriko Nitta; Masahiro Nakagawa; Masahito Kawazu; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa
BLOOD, Nov. 2007

AML1のリン酸化修飾がT細胞分化および造血発生に及ぼす影響
吉見真弓; 合山進; 河津正人; 中川正宏; 浅井隆司; 市川幹; 黒川峰夫
臨床血液, 30 Sep. 2007

AML1/Runx1 negatively regulates the number of quiescent hematopoietic stem cells in adult hematopoiesis.
Motoshi Ichikawa; Takashi Asai; Masahiro Nakagawa; Masahito Kawazu; Susumu Goyama; Masataka Takeshita; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa
BLOOD, Nov. 2006

転写因子AML1(Runx1)とマウス成体における造血幹細胞の維持機構
市川幹; 浅井隆司; 中川正宏; 河津正人; 合山進; 竹下昌孝; 千葉滋; 小川誠司; 黒川峰夫
臨床血液, 30 Sep. 2006

未熟胸腺細胞における転写因子AML1(Runx1)による遺伝子発現制御の解析
河津正人; 浅井隆司; 中村文彦; 山本豪; 中川正宏; 瀬尾幸子; 市川幹; 千葉滋; 小川誠司; 黒川峰夫
臨床血液, 30 Sep. 2006

Runx1によるNotch1欠損マウスP‐Spのin vitro造血能の回復
中川正宏; 市川幹; 熊野恵城; 合山進; 河津正人; 浅井隆司; 小川誠司; 黒川峰夫; 千葉滋
日本癌学会学術総会記事, 28 Aug. 2006

AML‐1によるNotch1欠損マウスP‐Spのin vitro造血能の回復
中川正宏; 市川幹; 熊野恵城; 合山進; 河津正人; 小川誠司; 黒川峰夫; 千葉滋
臨床血液, 30 Aug. 2005

External funds: Kakenhi

comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics.
Grant-in-Aid for Scientific Research (S)
Broad Section I
Kyoto University
小川誠司
From 26 Jun. 2019, To 31 Mar. 2024, Granted
ゲノム生物学;腫瘍学
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H05656/

Analysis of residual disease using newly developed single cell RNA sequencing.
Grant-in-Aid for Scientific Research (C)
Kyoto University
Masahiro Nakagawa
From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
単一細胞解析;白血病;骨髄異形成症候群;シングルセル解析;単一細胞;遺伝子発現
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09926/

Functional analysis of AML1-target genes in hematological malignancy.
Grant-in-Aid for Young Scientists (B)
The University of Tokyo
Masahiro NAKAGAWA
From 01 Apr. 2008, To 31 Mar. 2010, Project Closed
血液内科学;シグナル伝達;癌;白血病;AML1;NF-kB
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790670/

血液細胞でのRunx1/AML1による転写制御ネットワークの解明
Grant-in-Aid for Young Scientists (Start-up)
The University of Tokyo
中川正宏
From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
シグナル伝達;癌;マイクロアレイ
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18890057/

Hematopoietic stem cell regulation by the Notch signaling-including hematopoietic stem cell induction from human embryonic stem cells-
Grant-in-Aid for Scientific Research (B)
The University of Tokyo
Shigeru CHIBA
From 01 Apr. 2005, To 31 Mar. 2007, Project Closed
移植・再生医療;細胞・組織;トランスレーショナルリサーチ;発生・分化;再生医学;シグナル伝達, transplantation, regeneration medicine;cells, tissues;translational research;development, differentiation
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390274/

マルチオミクス単一細胞解析を用いた白血病進展機構の解明
Grant-in-Aid for Scientific Research (C)
Basic Section 54010:Hematology and medical oncology-related
Kyoto University
中川正宏
From 01 Apr. 2022, To 31 Mar. 2025, Granted
クローン選択;炎症;白血病;クローン性造血;単一細胞解析;骨髄異形成症候群;クローン造血
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08451/

Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues
Grant-in-Aid for Scientific Research (B)
Basic Section 56010:Neurosurgery-related
Kyoto University
荒川芳輝
From 01 Apr. 2022, To 31 Mar. 2026, Granted
グリオーマ;正常脳;IDH変異型クローン;先制医療;3次元的網羅的ゲノム解析
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03186/

Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues
Grant-in-Aid for Scientific Research (B)
Basic Section 56010:Neurosurgery-related
Kyoto University
荒川芳輝
From 01 Apr. 2022, To 31 Mar. 2026, Granted
グリオーマ;正常脳;IDH変異型クローン;先制医療;3次元的網羅的ゲノム解析
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24445/

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Nakagawa, Masahiro

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External funds: Kakenhi