Basic Information

Faculty

• 医学部

Academic Degree

• Doctor of Philosophy(Tokyo Medical and Dental University)

Research History

• From Oct. 2021, To Present

  Kyoto University, Graduate School of Medicine Institute of Laboratory Animals, Assistant Professor

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0002-9878-0433

• J-Global ID

  201401086343615876

researchmap URL

• https://researchmap.jp/7000008421

Research

Research Topics, Overview of the research

• Research Topics

  Studies on the roles of extracellular-matrix-regulators in animal development, homeostasis, and tumor suppression.

• Overview of the research

  The tumor suppressor protein RECK has been implicated in the regulation of matrix metalloproteinases (MMPs), Notch-signaling, and WNT7-signaling. We recently found that RECK plays roles essential for vascular development in mouse central nervous system (CNS) not only on the receptor (GPR124-FZD-LRP) side but also on the ligand (Wnt7a/b) side of WNT7-signaling. In adult mouse, RECK is expressed abundantly in growth hormone (GH)-producing cells in anterior pituitary gland. We found that RECK contributes to the stabilization of several receptors involved in the GH-IGF1 axis (i.e., GHRHR, GHSR, GHR). We also found that RECK and fibrillin-1 are coexpressed in many human tissues. Fibrillin-1 mutations are found in Marfan syndrome. Our data suggest that three proteins, RECK, ADAMTS10 (secreted metalloprotease), and MT1-MMP (secreted membrane-bound matrix-metalloprotease) cooperate to support the formation of robust fibrillin-1 fibers. Interestingly, RECK is capable of activating proMT1-MMP in mouse dermal fibroblasts while it inhibits mature MT1-MMP in vitro. These findings shed some new lights on the physiological functions of RECK, the molecular mechanisms of fibrillin fiber formation, and the molecular bases of diseases such as cancer, growth defects, and connective tissue disorders.

Research Areas

• Life sciences, Molecular biology

Papers

• Non-cell-autonomous suppression of tumor growth by RECK in immunocompetent mice.

  Tomoko Matsuzaki; Joe Inoue; Nagahiro Minato; Makoto Noda

  Journal of cellular physiology, 05 Aug. 2024

  
• Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.

  Tomonori Masuda; Akihisa Fukuda; Go Yamakawa; Mayuki Omatsu; Mio Namikawa; Makoto Sono; Yuichi Fukunaga; Munemasa Nagao; Osamu Araki; Takaaki Yoshikawa; Satoshi Ogawa; Kenji Masuo; Norihiro Goto; Yukiko Hiramatsu; Yu Muta; Motoyuki Tsuda; Takahisa Maruno; Yuki Nakanishi; Toshihiko Masui; Etsuro Hatano; Tomoko Matsuzaki; Makoto Noda; Hiroshi Seno

  The Journal of clinical investigation, 15 Sep. 2023

  Access this paper :

  
• SPECIFIC POINT-MUTATIONS POTENTIATE TUMOR SUPPRESSING ACTIVITY IN KREV-1

  M NODA; H KITAYAMA; Y SUGIMOTO; T MATSUZAKI; Y IKAWA

  ONCOGENESIS : ONCOGENES IN SIGNAL TRANSDUCTION AND CELL PROLIFERATION, 1990, Peer-reviewed

  
• Reversion‐inducing cysteine‐rich protein with Kazal motifs and MT1‐MMP promote the formation of robust fibrillin fibers

  Tomoko Matsuzaki; Douglas R. Keene; Emi Nishimoto; Makoto Noda

  Journal of Cellular Physiology, Mar. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice.

  Shuichiro Ogawa; Tomoko Matsuzaki; Makoto Noda

  Molecular and cellular endocrinology, 15 May 2020, Peer-reviewed

  Access this paper :

  
• RECK in Neural Precursor Cells Plays a Critical Role in Mouse Forebrain Angiogenesis.

  Li H; Miki T; Almeida GM; Hanashima C; Matsuzaki T; Kuo CJ; Watanabe N; Noda M

  iScience, Sep. 2019, Peer-reviewed

  
• The RECK tumor suppressor protein binds and stabilizes ADAMTS10

  TomokoMatsuzaki; HitoshiKitayama; AkiraOmura; EmiNishimoto; DavidB.Alexander; MakotoNoda

  Biology open, Oct. 2018, Peer-reviewed

  
• Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele

  Tomoko Matsuzaki; Huan Wang; Yukio Imamura; Shunya Kondo; Shuichiro Ogawa; Makoto Noda

  Genesis, 01 Apr. 2018, Peer-reviewed

  
• Critical roles for murine Reck in the regulation of vascular patterning and stabilization

  Glicia Maria de Almeida; Mako Yamamoto; Yoko Morioka; Shuichiro Ogawa; Tomoko Matsuzaki; Makoto Noda

  SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed

  Access this paper :

  
• The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

  Mako Yamamoto; Tomoko Matsuzaki; Rei Takahashi; Eijiro Adachi; Yasuhiro Maeda; Sachiyo Yamaguchi; Hitoshi Kitayama; Michiko Echizenya; Yoko Morioka; David B. Alexander; Takeshi Yagi; Shigeyoshi Itohara; Takashi Nakamura; Haruhiko Akiyama; Makoto Noda

  BIOLOGY OPEN, May 2012, Peer-reviewed

  
• Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice

  Ediriweera P. S. Chandana; Yasuhiro Maeda; Akihiko Ueda; Hiroshi Kiyonari; Naoko Oshima; Mako Yamamoto; Shunya Kondo; Junseo Oh; Rei Takahashi; Yoko Yoshida; Satoshi Kawashima; David B. Alexander; Hitoshi Kitayama; Chiaki Takahashi; Yasuhiko Tabata; Tomoko Matsuzaki; Makoto Noda

  BMC DEVELOPMENTAL BIOLOGY, Aug. 2010, Peer-reviewed

  Access this paper :

  
• What we learn from transformation suppressor genes: lessons from RECK

  Makoto Noda; Chiaki Takahashi; Tomoko Matsuzaki; Hitoshi Kitayama

  FUTURE ONCOLOGY, Jul. 2010, Peer-reviewed

  
• Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

  F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda

  ONCOGENE, May 2010, Peer-reviewed

  
• Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts

  Mamiko Hatta; Tomoko Matsuzaki; Yoko Morioka; Yoko Yoshida; Makoto Noda

  CELLULAR SIGNALLING, Dec. 2009, Peer-reviewed

  Access this paper :

  
• The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts

  Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D. B. Alexander; H. Kitayama; M. Noda

  ONCOGENE, Mar. 2009, Peer-reviewed

  
• RECK Forms Cowbell-shaped Dimers and Inhibits Matrix Metalloproteinase-catalyzed Cleavage of Fibronectin

  Akira Omura; Tomoko Matsuzaki; Kazuhiro Mio; Toshihiko Ogura; Mako Yamamoto; Akiko Fujita; Katsuya Okawa; Hitoshi Kitayama; Chiaki Takahashi; Chikara Sato; Makoto Noda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2009, Peer-reviewed

  
• Isolation of Hyperactive Mutants of Mammalian Target of Rapamycin

  Yoichiro Ohne; Terunao Takahara; Riko Hatakeyama; Tomoko Matsuzaki; Makoto Noda; Noboru Mizushima; Tatsuya Maeda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2008, Peer-reviewed

  
• Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line

  T Matsuzaki; K Aisaki; Y Yamamura; M Noda; Y Ikawa

  ONCOGENE, Mar. 2000, Peer-reviewed

  
• Erythropoietin and friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells

  Y Yamamura; H Senda; Y Kageyama; T Matsuzaki; M Noda; Y Ikawa

  MOLECULAR AND CELLULAR BIOLOGY, Mar. 1998, Peer-reviewed

  
• Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene

  C Takahashi; N Akiyama; T Matsuzaki; S Takai; H Kitayama; M Noda

  ONCOGENE, May 1996, Peer-reviewed

  
• A NEW RETROVIRAL VECTOR FOR DETECTING MUTATIONS AND CHROMOSOMAL INSTABILITY IN MAMMALIAN-CELLS

  S MURATA; T MATSUZAKI; S TAKAI; H YAOITA; M NODA

  MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS, Jun. 1995, Peer-reviewed

  
• MOLECULAR-CLONING AND BIOLOGICAL-ACTIVITY OF A NOVEL DEVELOPMENTALLY-REGULATED GENE ENCODING A PROTEIN WITH BETA-TRANSDUCIN-LIKE STRUCTURE

  S KUMAR; T MATSUZAKI; Y YOSHIDA; M NODA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1994, Peer-reviewed

  
• GENETIC-ANALYSIS OF THE K-REV-1 TRANSFORMATION-SUPPRESSOR GENE

  H KITAYAMA; T MATSUZAKI; Y SUGIMOTO; Y IKAWA; M NODA

  ENVIRONMENTAL HEALTH PERSPECTIVES, Jun. 1991, Peer-reviewed

  
• A DOMAIN RESPONSIBLE FOR THE TRANSFORMATION SUPPRESSOR ACTIVITY IN KREV-1 PROTEIN

  H KITAYAMA; T MATSUZAKI; Y IKAWA; M NODA

  JAPANESE JOURNAL OF CANCER RESEARCH, May 1990, Peer-reviewed

  
• TRANSFORMATION SUPPRESSOR GENES

  M NODA; H KITAYAMA; S KANAZAWA; S MURATA; T MATSUZAKI; Y IKAWA

  GENETIC BASIS FOR CARCINOGENESIS, 1990, Peer-reviewed

  
• BIOLOGICAL-ACTIVITIES OF THE TRANSFORMATION SUPPRESSOR GENE KREV-1 AND ITS MUTANTS

  M NODA; H KITAYAMA; Y SUGIMOTO; T MATSUZAKI; Y NAGANO; Y IKAWA

  RECESSIVE ONCOGENES AND TUMOR SUPPRESSION, 1989, Peer-reviewed

  
• A RAS-RELATED GENE WITH TRANSFORMATION SUPPRESSOR ACTIVITY

  H KITAYAMA; Y SUGIMOTO; T MATSUZAKI; Y IKAWA; M NODA

  CELL, Jan. 1989, Peer-reviewed

  

Misc.

• Critical roles for murine Reck in the regulation of vascular patterning and stabilization (vol 5, 17860, 2015)

  Glicia Maria de Almeida; Mako Yamamoto; Yoko Morioka; Shuichiro Ogawa; Tomoko Matsuzaki; Makoto Noda

  SCIENTIFIC REPORTS, Mar. 2016

  
• TRANSFORMATION SUPPRESSOR GENES

  M NODA; H KITAYAMA; S KANAZAWA; S MURATA; S KUMAR; T MATSUZAKI; Y IKAWA

  BRITISH JOURNAL OF CANCER, Sep. 1990

  
• GENETIC-ANALYSIS OF THE KIRSTEN-RAS-REVERTANT-1 GENE - POTENTIATION OF ITS TUMOR SUPPRESSOR ACTIVITY BY SPECIFIC POINT MUTATIONS

  H KITAYAMA; T MATSUZAKI; Y IKAWA; M NODA

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 1990, Peer-reviewed

  
• DETECTION OF GENES WITH A POTENTIAL FOR SUPPRESSING THE TRANSFORMED PHENOTYPE ASSOCIATED WITH ACTIVATED RAS GENES

  M NODA; H KITAYAMA; T MATSUZAKI; Y SUGIMOTO; H OKAYAMA; RH BASSIN; Y IKAWA

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 1989, Peer-reviewed

  

External funds: Kakenhi

• The roles of RECK tumor suppressor protein in angiogenesis

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  MAKOTO NODA

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  組織細胞;循環器・高血圧;生体分子;癌;発生・分化;組織・細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460390/
• Regulation of pericellular proteolysis and neural development

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Makoto NODA

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  組織細胞;神経科学;生体分子;脳・神経;発生・分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22123005/
• Elucidating the role of extracellular matrix remodeling on the fate and behavior of neuron

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Makoto NODA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  がん;発生;マウス遺伝学;MMP;ADAM;Notch;シグナル伝達;RECK;細胞外マトリックス;fibronectin;細胞密度;細胞移動;酸素濃度;神経筋接合部;骨格筋発生;MMP7;focal adhesion;細胞運動;神経分化;nestin;白質病変;MMP-2;パーキンソン病;Sept4;MRF;筋肉発生;Rb;N-ras

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17024026/
• Roles and Regulatory Mechanisms of Extracellular Matrix Remodeling in vivo

  Grant-in-Aid for Creative Scientific Research

  Kyoto University

  Makoto NODA

  From 01 Apr. 2004, To 31 Mar. 2010, Project Closed

  がん;発生;マウス遺伝学;MMP;ADAM;Notch;シグナル伝達;RECK;細胞マトリックス;fibronectin;細胞移動;細胞密度;血清濃度;酸素濃度;条件的遺伝子欠損マウス;Ras;発現遺伝子プロファイリング;軟骨分化;MT1-MMP;CD13;Rg13;profilin II;MMP-2;Sept4;MRF;筋肉発生;Rb;N-Ras;甲状腺腫瘍;septin;精子形成;Rap1;C3G;endomucin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16GS0311/
• Elucidation of Cancer Immunoregulatory System by Cancer Suppressor Gene RECK

  Grant-in-Aid for Scientific Research (C)

  Basic Section 50010:Tumor biology-related

  Kyoto University

  松崎 朋子

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  RECK;tumorigenesis;ECM;immunocompetent cell;transplantation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10332/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Animal Science

  8030, Spring, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Animal Science

  8030, Spring, Faculty of Medicine, 1

Administration

Faculty management (title, position)

• 医学図書委員
• ウサギ、ラット小委員会
• From 01 Apr. 2013, To 31 Mar. 2019

  動物実験施設運営委員会